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Pancreatic peritonal carcinomatous

Akiko Inoue, Akira Onose, Hiroka Onishi, Hisayo Isono, Matakichi Miyamoto, Hiroshi Nagata, Terue Sakakibara
A 48-year-old man with no remarkable medical history presented with upper abdominal pain for approximately 1 month. He was diagnosed as having pancreatic carcinoma with liver and lung metastasis and complicating carcinomatous peritonitis. Despite chemotherapy, his performance status worsened, his appetite deteriorated, and his pain became intolerable. The patient opted to return home for palliative care, and his parents, aged over 70 years, supported this decision. Although corticosteroid and opiate administration was attempted to improve appetite loss and pain, oral administration became difficult over a short span of time...
December 2013: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Shohei Ikeda, Kenji Okubo, Hiroaki Shibahara, Michihiko Narita, Kiyoshi Morita, Atsufumi Takeuchi, Hironobu Kanazawa, Takanori Ito, Daisaku Nishimura, Naoyuki Katada
This paper presents a woman in her 70's with G-CSF producing anaplastic carcinoma of the pancreas(Stage IVb)who underwent chemotherapy by S-1 alone. On FDG-PET after the first course, accumulation of FDG was impaired remarkably. After the second course, the patient died of carcinomatous pleuritis and peritonitis on the 88th day after initiation of treatment. G-CSF producing anaplastic carcinoma of the pancreas is extremely rare and there are no reports with regard to response evaluation by FDG-PET. Thus, this case has significant clinical value...
June 2013: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Yoko Matsuda, Masahito Hagio, Zenya Naito, Toshiyuki Ishiwata
The annual incidence of pancreatic carcinoma has been increasing worldwide, and the overall 5-year survival rate has remained at approximately 5%. We re-evaluated 30 autopsy cases histologically diagnosed as pancreatic carcinoma from 1994 through 2010 at Nippon Medical School Hospital. The mean patient age was 69.5 years, with no significant differences between male and female patients. The location of the primary tumor was most often the head of the pancreas (46.7%), followed by the body (36.7%) and tail (16...
2012: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
Fumihiro Okumura, Kyoji Senoo, Michihiro Yoshida, Katsuyuki Miyabe, Itaru Naito, Hajime Tanaka, Kazuki Hayashi, Tomoaki Ando, Takahiro Nakazawa, Hirotaka Ohara, Katsura Hamaguchi, Michio Kanai, Kazuyuki Ito, Takashi Joh
A 72-year-old woman was admitted with an abdominal tumor, which had been detected by computed tomography scanning. Endoscopic examination of the upper gastrointestinal tract revealed a type 3 tumor in the descending limb of the duodenum. A diagnosis of adenocarcinoma was made on the basis of the histological analysis of the biopsy sample. Pancreatoduodenectomy was performed, and peritoneal dissemination was confirmed at surgery. The pathological findings indicated primary duodenal cancer (mucinous carcinoma) associated with tumor thrombosis in the accessory pancreatic duct...
December 2009: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
Norihiro Okamoto, Keisuke Inaba, Hiroyuki Konno
The prognosis for advanced pancreatic cancer with peritoneal dissemination is extremely poor, and no effective standard therapy has been established. We present a case of a very old patient whose QOL improved shortly after administration of only S-1 to treat advanced pancreatic cancer with peritoneal dissemination. A 85-year-old man presented to our hospital with anorexia and loss of weight. CT scanning showed severe ascites and a low-density area 2 cm wide at the tail of the pancreas. Ascitic cytology revealed adenocarcinoma and carcinomatous peritonitis due to pancreatic cancer...
July 2009: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Valérie Untereiner, Olivier Piot, Marie-Danielle Diebold, Olivier Bouché, Elodie Scaglia, Michel Manfait
Fourier transform infrared (FTIR) spectroscopy is nowadays widely accepted as a technique with high potential for diagnosis of cancerous tissues. This study presents an example of the investigation of peritoneal metastases by FTIR microimaging. Peritoneal malignancies are generally secondary localizations of primary visceral cancers such as ovarian, stomach or colon cancers. By analysing simultaneously both formalin-fixed paraffin-embedded and frozen specimens, we examined malignant and non-malignant (i.e. fibrotic and cicatricial) peritoneal lesions...
March 2009: Analytical and Bioanalytical Chemistry
Tetsuya Yamaguchi, Hiroshi Takahashi, Ryuzaburo Kagawa, Ryoji Takeda, Shingo Sakata, Michihiro Yamamoto, Daisuke Nishizaki
A 72-year-old man presented with several week's abdominal distension and jaundice. Under the tentative diagnosis of pancreatic pseudocyst of 22cm in diameter, a percutaneous drainage was performed. Despite the reduction of the pseudocyst, his serum total bilirubin level was increased. At this time, abdominal computed tomography scan showed a tumor at the uncinate process of the pancreas. After the biliary decompression, a total pancreatectomy with the resection of pseudocyst walls and splenectomy was performed...
March 2007: Hepato-gastroenterology
Takahiro Mimae, Motoki Ninomiya, Hiroshi Sasaki, Youji Kubo, Tohru Kojima, Tatsuo Umeoka, Norihisa Takakura
A 29-year-old male underwent Cur B surgery including total gastrectomy, pancreaticoduodenectomy, transverse colectomy, and D 2 dissection for scirrhous gastric carcinoma accompanied by duodenal and pancreatic infiltration. Thereafter, the patient suffered from recurrence with development of ileus caused by carcinomatous peritonitis. Ileus tube was inserted, followed by conservative therapy without ingestion. But, as the symptoms aggravated without any alleviation, an emergency surgical procedure was conducted...
February 2006: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Toshio Nakagohri, Masaru Konishi, Kazuto Inoue, Yutaka Tanizawa, Taira Kinoshita
BACKGROUND/AIMS: Most patients with intraductal papillary mucinous tumors of the pancreas have a favorable prognosis after surgical treatment. However, recurrent disease frequently occurs in patients with invasive carcinoma derived from intraductal papillary mucinous carcinoma. The objective of this study was to clarify the clinicopathological features of invasive carcinoma derived from intraductal papillary mucinous carcinoma. METHODOLOGY: We performed a retrospective review of the 29 patients with intraductal papillary mucinous tumor including 10 patients with invasive carcinoma who underwent pancreatic resection between June 1995 and December 2001 at the National Cancer Center Hospital East...
September 2004: Hepato-gastroenterology
Tae Sato, Akihiko Ohwada, Atsuko Miyaji, Ryoichiro Miyazaki, Masaru Suzuki, Toshiharu Matsumoto
We report a woman with ascites, hydrothorax, pancreatic tumor, left cystic ovarian tumor, and an elevated serum cancer antigen 125 level. Exploratory laparotomy was performed to determine peritoneal disseminated carcinoma of unknown origin. Immunohistochemical analysis demonstrated positive staining for carcinoembryonic antigen, trypsin, and progesterone receptor and nonspecific or negative reaction for calretinin, estrogen receptor, amylase, lipase, Wilms tumor gene 1 protein, and inhibin or chromogranin A...
May 2004: Internal Medicine
Takuya Inoue, Shigeaki Nagao, Hitomi Tajima, Keisuke Okudaira, Kazutoshi Hashiguchi, Junichi Miyazaki, Koji Matsuzaki, Yoshikazu Tsuzuki, Atsushi Kawaguchi, Kazuro Itoh, Ben Hatano, Sho Ogata, Soichiro Miura
An autopsy case of adenosquamous pancreatic cancer in a 61-year-old male patient with an elevated serum level of parathyroid hormone-related protein (PTH-rP) is reported. He was admitted to our hospital with a 1-month-long history of abdominal discomfort and progressive abdominal fullness. A computed tomography (CT) scan of the abdomen showed a retroperitoneal mass, approximately 10 cm in diameter, involving the pancreas, with round enhancement on contrast examination. Histological examination of a specimen taken by CT-guided needle biopsy suggested squamous cell carcinoma or transitional cell carcinoma...
2004: Journal of Gastroenterology
P P Mainenti, L Romano, A Contegiacomo, M Romano, V Casella, A Cuccuru, L Insabato, M Salvatore
In the peritoneal cavity, diffuse serosal replacement by tumor is demonstrated usually by extensive carcinomatous involvement from gastric, colonic, or pancreatic tumors or less frequently by mesothelioma. Primary tumors other than mesothelioma are extremely rare in the peritoneum. The computed tomographic appearances of two cases of rare peritoneal tumors, epithelioid hemangioendothelioma and desmoplastic small round cell tumor, are described.
November 2003: Abdominal Imaging
Fumika Hatanaka, Susumu Matsuo, Yoshifusa Aratake, Koutaro Uchimura, Masaki Yokota, Toshihiko Sumii, Haruo Iguchi, Akihiro Funakoshi
A 62-year-old man with carcinomatous ascites more than 5 years after early gastric cancer operation was admitted to our hospital because of suspected pancreatic cancer, and was diagnosed with a relapse of the gastric cancer. TS-1 was administered at a dose of 120 mg/day. At the end of 1 course a partial response of a decrease of tumor markers and ascites and improvement of QOL was achieved, and the patient was followed in the outpatient clinic. The current case suggests that TS-1 may have a potent therapeutic efficacy in cases of gastric cancer relapse with carcinomatous ascites...
May 2003: Gan to Kagaku Ryoho. Cancer & Chemotherapy
N Takahashi, R Masamune, Y Kunii
A 66-year-old woman was admitted to our hospital complaining of abdominal pain and jaundice. Upper gastrointestinal series and computed tomography revealed pancreatic cancer. Pancreatectomy could not be performed because of portal invasion and multiple liver metastasis. Cholecystectomy, choledochojejunostomy and gastrojejunostomy were performed. The patient was treated with methotrexate (MTX) 100 mg/m2 i.v. followed one hour later with 5-fluorouracil (5-FU) 700 mg/m2. Leucovorin rescue of 10 mg po was given 24 hours after MTX administration...
January 1999: Gan to Kagaku Ryoho. Cancer & Chemotherapy
N Sakamoto
This paper describes the antitumor effect of human lactoferrin against the human pancreatic cancer cell line SPA, which was newly established in our laboratory from a metastatic liver tumor of pancreatic origin. In tissue culture, the cancer cells proliferated rapidly at 16 hours of doubling time, and produced tumor markers into the culture medium at a high concentration. Subcutaneous and intraperitoneal transplantation of these neoplastic cells into nude mice resulted in tumor formation and carcinomatous peritonitis...
August 1998: Gan to Kagaku Ryoho. Cancer & Chemotherapy
N Nishimura, S Saito, Y Kubota, N Moto-o, K Taguchi, K Yamazaki, A Watanabe, H Sasaki
Two human pancreatic carcinoma cell lines, designated HuP-T3 and HuP-T4, were established from the ascites of pancreatic cancer patients with carcinomatous peritonitis. The cell lines were grown in monolayer cultures and had population doubling times of 38.6 and 37.1 h, respectively. HuP-T4 secreted large amounts of CEA and CA19-9 into the medium, and HuP-T3 produced a small amount of CEA, but no CA19-9. Both cell lines showed tumorigenicity in nude mice. Histologically, the HuP-T3-derived tumor was poorly differentiated adenocarcinoma, and the HuP-T4-derived tumor was well differentiated papillotubular adenocarcinoma...
February 1993: International Journal of Pancreatology: Official Journal of the International Association of Pancreatology
H Saito, A Takamura, Y Sakurai, K Horio, T Ohta, M Yamano, Y Sawaguchi, Y Sato
The prognosis for hepatic metastasis from pancreatic adenocarcinoma is generally poor. Estrogen receptors have recently been demonstrated in pancreatic adenocarcinoma, and it has been suggested that tamoxifen increases patient survival. We have tried tamoxifen therapy combined with intermittent intraarterial infusion chemotherapy using mainly 5-FU for 4 patients with hepatic metastasis from pancreatic adenocarcinoma. Clinical evaluation of initial response was available for these 4 patients. Although the number of the patients in this study was small, we obtained a response rate of 50%; CR in one case, PR in one case...
November 1993: Gan to Kagaku Ryoho. Cancer & Chemotherapy
T Oku, M Hasegawa, I Watanabe, M Nasu, N Aoki
A laryngeal metastasis from pleomorphic carcinoma of the pancreas is described. The patient was a 70-year-old male. The tumour was located on the right margin of the epiglottis. Bilateral neck lymph node metastases were also found. The patient underwent supraglottic laryngectomy, right radical neck dissection and left suprahyoid neck dissection. Following surgery, the patient's general condition deteriorated day by day, and one month after the surgery he died. The autopsy findings demonstrated a big mass of cancer in the pancreatic tail, multiple lymphatic metastases, carcinomatous peritonitis, and possibly a lymphatic spread of the pancreatic cancer to the larynx...
October 1980: Journal of Laryngology and Otology
K Koda, O Nakazawa, S Terada, T Kure, K Morita, M Hirayama, A Fukushi, T Terui, N Yoshizaki, H Takahashi
Ten patients with carcinomatous peritonitis of gastrointestinal cancer have been treated with administrations of CDDP-Ip (50-150 mg/body), in combination with systemic chemotherapy simultaneously combined with sodium thiosulfate (STS) iv in 4 patients. All patients received transfusions of specific hydration. The pharmacokinetics of CDDP was studied in 4 patients, and the following results were obtained. (1) As for its effect on malignant ascites, according to Koyama's and Saito's criteria, 2 patients showed a complete response, 3 showed a partial response, and 5 showed no change...
February 1988: Gan No Rinsho. Japan Journal of Cancer Clinics
S Yoshino, M Oka, S Hazama, T Suzuki
Eleven patients, seven with carcinomatous pleuritis and four with carcinomatous peritonitis, were treated with the intrapleural and/or intraperitoneal administration of Lentinan (4 mg/week X 4). And the following results were obtained. (1) Eight patients revealed a clinical effect; malignant effusion disappeared in two and diminished in two. In six, the cytological grade decreased. (2) Subpopulations of peripheral blood lymphocytes (PBL) and pleural or peritoneal effusion mononuclear cells (PEMNC) were examined using monoclonal antibodies (OKT4, OKT8, Leu7, CD8 X CD11)...
May 1, 1989: Nihon Geka Hokan. Archiv Für Japanische Chirurgie
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