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archives of neurology

Marie McCann, Donna M Bayliss, Carmela Pestell, Catherine M Hill, Romola S Bucks
The objective of this study is to investigate whether sleep problems might account for the increased working memory deficits observed in school-aged children with neurological conditions. A novel, transdiagnostic approach to the investigation was chosen, and sleep is treated as a process that can potentially account for working memory difficulties across a range of neurological conditions. Prevalence estimates of sleep problems are also examined. Archival data of 237 children aged 6 to 11 years were collected from a Western Australian statewide neuropsychological service for the period 26 July 2011 to 14 January 2014...
October 3, 2016: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
Astra Cabaj, Monika Bekiesińska-Figatowska, Agnieszka Duczkowska, Marek Duczkowski
The amount of people living with cancer is increasing; they live longer and have thus a higher risk of developing neurological complications. Magnetic resonance as a diagnostic procedure of choice in detecting the reasons of neurological/psychiatric symptoms in oncological patients is nowadays relatively easily accessible. Early diagnosis established by radiologists familiar with neurological entities that may follow cancer treatment allow clinicians to provide proper treatment, even if the diagnosis seems unbelievable...
July 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Teresa Corona, Amin Cervantes-Arriaga, Leora Velásquez-Pérez, Mayela Rodríguez-Violante
BACKGROUND: Outpatient clinics for movement disorders provide specialized diagnosis and treatment services for the specific needs of this patient population. OBJECTIVE: Describe the impact of implementing a Movement Disorder Clinic on the trends of consultations per year and hospitalizations of subjects with Parkinson's disease at a tertiary referral center. METHODS: A retrospective study was carried out. We collected data from the Clinical File Archive and the Epidemiology Department at the National Institute of Neurology and Neurosurgery in Mexico...
July 2016: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
Angela E Rankine-Mullings, Courtney R Little, Marvin E Reid, Deanne P Soares, Carolyn Taylor-Bryan, Jennifer M Knight-Madden, Susan E Stuber, Asha V Badaloo, Karen Aldred, Margaret E Wisdom-Phipps, Teresa Latham, Russell E Ware
BACKGROUND: Cerebral vasculopathy in sickle cell anemia (SCA) begins in childhood and features intracranial arterial stenosis with high risk of ischemic stroke. Stroke risk can be reduced by transcranial doppler (TCD) screening and chronic transfusion therapy; however, this approach is impractical in many developing countries. Accumulating evidence supports the use of hydroxyurea for the prevention and treatment of cerebrovascular disease in children with SCA. Recently we reported that hydroxyurea significantly reduced the conversion from conditional TCD velocities to abnormal velocities; whether hydroxyurea can be used for children with newly diagnosed severe cerebrovascular disease in place of starting transfusion therapy remains unknown...
September 12, 2016: JMIR Research Protocols
P J Egan, T C Mitrovics, B F Tomandl
Routine magnetic resonance imaging (MRI) of the skull and brain for diagnostic purposes sometimes reveals a wider tip of the frontal ventricular horn on one side and a wider tip of the temporal horn on the other. A search for 'alternate ventricular asymmetry' in Google Scholar, Medline and PubMed Central yielded no results, so the digital archive of the hospital was searched for such cases. A total of 5908 examinations were reviewed and 508 cases were found, comprising 6% of the neurological inpatients and 20% of the psychiatric inpatients (p=0...
September 6, 2016: Clinical Anatomy
Stefan M Pulst
As of April 8, 2016, articles in Neurology® Genetics can be searched using PubMed. Launched in 1996, PubMed is a search engine that accesses citations and abstracts of more than 26 million articles. Its primary sources include the MEDLINE database, which was started in the 1960s, and biomedical and life sciences journal articles that date back to 1946. In addition, PubMed accesses other sources, for example, citations to those life sciences journals that submit full-text articles to PubMed Central (PMC). PubMed Central was launched in 2000 as a free archive of biomedical and life science journals...
August 2016: Neurology. Genetics
William T Wilson, Tristan McMillan, Adam M H Young, Mark A J White
INTRODUCTION: Treatment-limiting decisions (TLDs) are employed to actively withhold treatment from patients whom clinicians feel would derive no benefit or suffer detrimental effects from further intervention. The use of such decisions has been heavily discussed in the media and clinicians in the past have been reluctant to institute them, even though it is in the best interests of the patients. Their use is influenced by several ethical, religious and social factors all of which have changed significantly over time...
September 1, 2016: British Journal of Neurosurgery
Linli Li, Youhai Dong, Yiqun He, Xiangsheng Liu, Wenqing Tong
Purpose To evaluate the efficacy of percutaneous pedicle screw fixation technique combined with three-step reduction in the treatment of thoracolumbar fracture. Methods This is a retrospective study, based on medical records from the archives of the Fifth People's Hospital of Fudan University, from January 2012 to January 2015. The 49 patients with thoracolumbar fracture were treated with percutaneous pedicle screw fixation technique combined with three-step reduction. The treatment plan was determined by the AO classification and the Thoracolumbar Injury Classification and Severity classification...
July 26, 2016: Journal of Neurological Surgery. Part A, Central European Neurosurgery
Yiannis A Savva, Ali Rezaei, Georges St Laurent, Robert A Reenan
Transcription of genetic information from archival DNA into RNA molecule working copies is vital for proper cellular function and is highly accurate. In turn, RNAs serve structural, enzymatic, and regulatory roles, as well as being informational templates for the ribosomal translation of proteins. Following RNA synthesis, maturing of RNA molecules occurs through various RNA processing events. One component of the collection of processes involving RNA species, broadly defined as RNA metabolism, is the RNA-editing pathway and is found in all animals...
2016: Frontiers in Genetics
Paritosh Pandey, V Subeikshanan, Venkatesh S Madhugiri
CONTEXT: The highest cited papers published in a journal provide a snapshot of the clinical practice and research in that specialty and/or region. AIMS: The aim of this study was to determine the highest cited papers published in Neurology India and analyze their attributes. SETTING AND DESIGN: This study was a citation analysis of all papers published in Neurology India since online archiving commenced in 1993. METHODS: All papers published in Neurology India between the years 1993-2014 were listed...
July 2016: Neurology India
Ellen Gelpi, Romana Höftberger, Francesc Graus, Helen Ling, Janice L Holton, Timothy Dawson, Mara Popovic, Janja Pretnar-Oblak, Birgit Högl, Erich Schmutzhard, Werner Poewe, Gerda Ricken, Joan Santamaria, Josep Dalmau, Herbert Budka, Tamas Revesz, Gabor G Kovacs
We recently reported a novel neurological syndrome characterized by a unique NREM and REM parasomnia with sleep apnea and stridor, accompanied by bulbar dysfunction and specific association with antibodies against the neuronal cell-adhesion protein IgLON5. All patients had the HLA-DRB1*1001 and HLA-DQB1*0501 alleles. Neuropathological findings in two patients revealed a novel tauopathy restricted to neurons and predominantly involving the hypothalamus and tegmentum of the brainstem. The aim of the current study is to describe the neuropathological features of the anti-IgLON5 syndrome and to provide diagnostic levels of certainty based on the presence of associated clinical and immunological data...
October 2016: Acta Neuropathologica
K-J Neumärker, B Holdorff
The physician and psychologist Dr. Fredy Quadfasel, born in East Prussia, was trained in neuropsychiatry by Kurt Goldstein in Frankfurt/Main and by Karl Bonhoeffer at the Charité in Berlin. After he was detained by the Gestapo due to political opposition, he was probably denounced for offending the so-called Malicious Practices Act (Heimtückegesetz) from March 1933, and imprisoned for 2-3 months. In 1934/35 he emigrated to the USA via England and Canada, where he initially ran a neuropsychiatry office in New York...
August 2016: Der Nervenarzt
Kristine Engen, Ingrid Agartz
BACKGROUND In 2007 a clinical disease caused by autoantibodies directed against the N-methyl-D-aspartate (NMDA) receptor was described for the first time. Anti-NMDA-receptor encephalitis is a subacute, autoimmune neurological disorder with psychiatric manifestations. The disease is a form of limbic encephalitis and is often paraneoplastic. The condition is also treatable. In this review article we examine the development of the disease, clinical practice, diagnostics and treatment.MATERIAL AND METHOD The article is based on references retrieved from searches in PubMed, and a discretionary selection of articles from the authors' own literature archive...
June 2016: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
Sharon Baughman Shively, Iren Horkayne-Szakaly, Robert V Jones, James P Kelly, Regina C Armstrong, Daniel P Perl
BACKGROUND: No evidence-based guidelines are available for the definitive diagnosis or directed treatment of most blast-associated traumatic brain injuries, partly because the underlying pathology is unknown. Moreover, few neuropathological studies have addressed whether blast exposure produces unique lesions in the human brain, and if those lesions are comparable with impact-induced traumatic brain injury. We aimed to test the hypothesis that blast exposure produces unique patterns of damage, differing from that associated with impact-induced, non-blast traumatic brain injuries...
August 2016: Lancet Neurology
Sanja Draca
Dr. Lazar K. Lazarević (1851-1890, Julian calendar/1891, Gregorian calendar) was an exceptional Serbian physician, scientist, writer and translator. During his short life and his close to 11-year-long professional career (1879-1890), Dr. Lazarević authored 78 scientific papers and presentations in various branches of medicine. His greatest contribution to the field of neurology and to medical science in general is his description of the straight leg raising test.The article titled"Ischiac postica Cotunnii--One contribution to its differential diagnosis"was published in the Serbian language (in Cyrillic alphabet) in the Serbian Archives of Medicine in 1880...
January 2016: Srpski Arhiv za Celokupno Lekarstvo
Lakshmanan Arunachalam, Iain A Hunter, Shane Killeen
OBJECTIVE: To determine the nature and frequency of distorted presentation or "spin" (ie, specific reporting strategies which highlight that the experimental treatment is beneficial, despite a statistically nonsignificant difference for the primary outcome, or distract the reader from statistically nonsignificant results) in published reports of randomized controlled trials (RCTs) with statistically nonsignificant results for primary outcomes in surgical journals. BACKGROUND: Multiple reports have suggested that interpretation of RCT results in medical journals can be distorted by authors of published reports...
June 1, 2016: Annals of Surgery
Kai Ivar Müller, Karl Bjørnar Alstadhaug, Svein Ivar Bekkelund
BACKGROUND: The feasibility of telemedicine in diagnosing and treating nonacute headaches, such as primary headaches (migraine and tension-type) and medication-overuse headaches has not been previously investigated. By eliminating the need of travel to specialists, telemedicine may offer significant time and money savings. OBJECTIVES: Our objective was to estimate the acceptance of telemedicine and investigate the feasibility and cost savings of telemedicine consultations in diagnosing and treating nonacute headaches...
2016: Journal of Medical Internet Research
Hülya Maraş Genç, Emek Uyur Yalçın, Murat Sayan, Asuman Bayhan, Selim Öncel, Emin Sami Arısoy, Bülent Kara
BACKGROUND: Herpes simplex virus encephalitis (HSE) is a significant cause of morbidity and mortality. Neurologic sequelae are common even after early initiation of acyclovir treatment. The host immune response during HSE can also lead to brain damage. There are an increasing number of reports favoring steroid use in HSE. OBJECTIVES: We aimed to compare the prognosis of children with HSE with and without steroid therapy. STUDY DESIGN: We retrospectively screened our hospital archive from 2009 to 2014 for patients diagnosed with HSE with a positive result for herpes simplex virus polymerase chain reaction in cerebrospinal fluid...
July 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
C Appleby-Mallinder, M D Wyles, J E Simpson, S B Wharton, P G Ince, P R Heath
BACKGROUND: Laser capture microdissection (LCM) is an established technique for the procurement of enriched cell populations that can undergo further downstream analysis, although it does have limitations. Expression microdissection (xMD) is a new technique that begins to address these pitfalls, such as operator dependence and contamination. NEW METHOD: xMD utilises immunohistochemistry in conjunction with a chromogen to isolate specific cell types by extending the fundamental principles of LCM to create an operator-independent method for the procurement of specific CNS cell types...
August 1, 2016: Journal of Neuroscience Methods
Anand M Prabhakar, H Benjamin Harvey, Katelyn N Brinegar, Ali S Raja, James R Kelly, James A Brink, Sanjay Saini, Rahmi Oklu
PURPOSE: The purpose of this study was to investigate the role of imaging in transfers between an island Critical Access Hospital (CAH) emergency department (ED) and a quaternary care hospital. METHODS: Electronic medical records were reviewed to identify all patients who were transferred from an island CAH to our quaternary care hospital in 2012 and 2013. Medical history, transfer diagnosis, and the type of imaging performed at the CAH prior to transfer were reviewed...
August 2016: American Journal of Emergency Medicine
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