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archives of neurology

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https://www.readbyqxmd.com/read/28470955/phenotypic-characterisation-of-cell-populations-in-the-brains-of-horses-experimentally-infected-with-west-nile-virus
#1
G H Delcambre, J Liu, W J Streit, G P J Shaw, K Vallario, J Herrington, N Wenzlow, K L Barr, M T Long
BACKGROUND: West Nile Virus (WNV), a mosquito borne member of the Flaviviridae, is one of the most commonly diagnosed agents of viral encephalitis in horses and people worldwide. OBJECTIVE: A cassette of markers for formalin-fixed paraffin-embedded (FFPE) tissue and an archive of tissues from experimental infections in the horse were used to investigate the equine neuroimmune response to WNV meningoencephalomyelitis to phenotype the early response to WNV infection in the horse...
May 4, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28341497/congenital-pseudarthrosis-of-the-clavicle-a-report-on-27-cases
#2
Giovanni Luigi Di Gennaro, Mattia Cravino, Alessandro Martinelli, Eleonora Berardi, Anish Rao, Stefano Stilli, Giovanni Trisolino
HYPOTHESIS: We aimed to report our experience in treating congenital pseudarthrosis of the clavicle (CPC). MATERIALS AND METHODS: A retrospective search of the archive of our institute was performed; 27 cases (12 male and 15 female patients) affected by CPC were recorded. Among these patients, 19 underwent surgical intervention for cosmetic appearance between 1960 and 2015. Of 19 patients, 18 were treated by pseudarthrosis resection and stabilization with a Kirschner wire, whereas in 1 case, the osteosynthesis was performed with a plate...
March 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28338452/differentiation-of-idiopathic-spinal-cord-herniation-from-dorsal-arachnoid-webs-on-mri-and-ct-myelography
#3
Randall Schultz, Andrew Steven, Aaron Wessell, Nancy Fischbein, Charles A Sansur, Dheeraj Gandhi, David Ibrahimi, Prashant Raghavan
OBJECTIVE Dorsal arachnoid webs (DAWs) and spinal cord herniation (SCH) are uncommon abnormalities affecting the thoracic spinal cord that can result in syringomyelia and significant neurological morbidity if left untreated. Differentiating these 2 entities on the basis of clinical presentation and radiological findings remains challenging but is of vital importance in planning a surgical approach. The authors examined the differences between DAWs and idiopathic SCH on MRI and CT myelography to improve diagnostic confidence prior to surgery...
March 24, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28334240/the-use-of-rbans-among-inpatient-forensic-monolingual-spanish-speakers
#4
Cynthia Aguilar, Kenny A Karyadi, Dominique I Kinney, Stephen R Nitch
Objective: The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) has been shown to be an effective screener for detecting neurocognitive impairments in English speaking forensic psychiatric inpatients, but no studies have examined whether the RBANS would have the same utility among monolingual Spanish speaking inpatients. This study sought to examine RBANS performance, as well as risk factors (i.e., educational, neurological, and medical) influencing RBANS performance, in that particular population...
June 1, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28290379/deep-tendon-reflex-the-background-story-of-a-simple-technique
#5
Kalyan B Bhattacharyya
Wilhelm Erb and Carl Otto Westphal from Prussia first described the knee jerk in the same issue of the journal Archiv für Psychiatrie und Nervenkrankheiten in January 1875. This article retraces the history of development of 'deep tendon reflex' as an integral clinical sign during every neurological examination. The history of the evolving shapes of the reflex hammer, the iconic trademark and the ultimate signature of a neuroscientist, is also presented.
March 2017: Neurology India
https://www.readbyqxmd.com/read/28242594/public-funding-and-open-access-to-research-a-review-of-canadian-multiple-sclerosis-research
#6
Caitlin Bakker, Carol Stephenson, Erin Stephenson, Debbie Chaves
BACKGROUND: Multiple sclerosis (MS), a progressive demyelinating disease of the brain and spinal cord, is the leading cause of nontraumatic neurological damage in young adults. Canada has one of the highest reported incidents of MS, with estimates between 55 and 240 per 100,000 individuals. Between 2009 and 2014, the MS Society of Canada provided over Can $90 million to researchers and, since 2013, has encouraged researchers to make both current and previous research products openly available...
February 27, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28225542/historical-overview-of-leprosy-control-in-cuba
#7
Enrique Beldarraín-Chaple
INTRODUCTION Leprosy, an infectious disease caused by Mycobacterium leprae, affects the nervous system, skin, internal organs, extremities and mucous membranes. Biological, social and environmental factors influence its occurrence and transmission. The first effective treatments appeared in 1930 with the development of dapsone, a sulfone. The main components of a control and elimination strategy are early case detection and timely administration of multidrug therapy. OBJECTIVES Review the history of leprosy control in Cuba, emphasizing particularly results of the National Leprosy Control Program, its modifications and influence on leprosy control...
January 2017: MEDICC Review
https://www.readbyqxmd.com/read/28186658/cerebrospinal-fluid-levels-of-phosphorylated-neurofilament-heavy-as-a-diagnostic-marker-of-canine-degenerative-myelopathy
#8
C M Toedebusch, M D Bachrach, V B Garcia, G C Johnson, M L Katz, G Shaw, J R Coates, M L Garcia
BACKGROUND: No definitive, antemortem diagnostic test for canine degenerative myelopathy (DM) is available. Phosphorylated neurofilament heavy (pNF-H) is a promising biomarker for nervous system diseases. HYPOTHESIS/OBJECTIVE: Cerebrospinal fluid (CSF) and serum pNF-H is a detectable biological marker for diagnosis of canine DM. ANIMALS: Fifty-three DM-affected, 27 neurologically normal, 7 asymptomatic at-risk, and 12 DM mimic dogs. METHODS: Archived CSF and serum pNF-H concentrations were determined by a commercially available ELISA...
March 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28127512/side-of-onset-of-parkinson-s-disease-in-relation-to-neuropsychological-measures
#9
Edward J Modestino, Chioma Amenechi, AnnaMarie Reinhofer, Patrick O'Toole
BACKGROUND: Parkinson's disease (PD) usually emerges with a unilateral side-of-onset (left-onset: LOPD; right-onset: ROPD; Marinus & van Hilten, 2015) due to an asymmetrical degeneration of striatal dopaminergic neurons (Donnemiller et al., Brain, 135, 2012, 3348). This has led to a body of research exploring the cognitive, neuropsychological, and clinical differences between LOPD and ROPD (e.g., Verreyt et al., Neuropsychology Review, 21, 2011, 405). METHODS: Thirty ROPD and 14 LOPD cases were drawn from a Boston clinic specializing in PD...
January 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28118630/the-development-of-sayk-s-cell-sedimentation-chamber-a-historical-view-on-clinical-cerebrospinal-fluid-diagnostics
#10
Nathalie Dahlmann, Uwe K Zettl, Ekkehardt Kumbier
OBJECTIVE: The history of Sayk's cell sedimentation chamber is examined and reviewed in the context of clinically utilizable cerebrospinal fluid (CSF) cytology. METHODS: A review of the literature was undertaken in PubMed and Google Scholar to search for primary and secondary sources on the history of CSF diagnosis. Moreover, documents in the archives of the Universities of Rostock and Jena, the Brain Research Institute of Cécile and Oskar Vogt in Düsseldorf and the Centre for Neurology at Rostock University were used...
2017: European Neurology
https://www.readbyqxmd.com/read/28101618/-neurological-and-psychiatric-journals-during-the-third-reich-national-socialistic-and-racist-contents
#11
D Claus
The aim of this study was to investigate scientific articles in three German journals for national socialist and racist contents. The three journals evaluated for the period of the Third Reich were the Der Nervenarzt, Deutsche Zeitschrift für Nervenheilkunde and the Archiv für Psychiatrie und Nervenkrankheiten. The specialist disciplines of neurology and psychiatry were united in the year 1935 and Ernst Rüdin, a neurological geneticist, was appointed as president (Reichsleiter) of the society. The universal idea of a degenerative development, which was believed to exert a negative influence on public health, was widely accepted in this time period; therefore, in some articles measures were called for, such as termination of pregnancy, sterilization and castration of diseased people and also of criminals...
February 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/28097244/minimising-costs-in-spinal-surgery-is-group-save-testing-justified-in-lumbar-decompression-surgery
#12
William T Wilson, Adam M H Young, Paul Fivey
BACKGROUND: Lumbar microdiscectomy and laminectomy are two of the most common neurosurgical procedures performed worldwide. Current practice still sees pre-operative group and save testing prior to this surgery. The aim of this study was to determine the need for pre-operative group and save and post-operative blood checks. METHODS: Patient archives were reviewed to identify those undergoing primary elective lumbar decompression surgery at the Institute of Neurological Sciences, Queen Elizabeth University Hospital, Glasgow, UK...
December 2016: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/28095960/medical-reasons-for-loss-of-license-in-norwegian-professional-pilots
#13
Jesper Kristiansen Høva, Lars Thorheim, Anthony S Wagstaff
BACKGROUND: The aim of this study was to quantify causes of medical disqualification (groundings) of Norwegian commercial pilots for the period 2006-2010, and to compare our findings with former Norwegian studies on the subject to reveal possible changes in the disease spectrum over the last decades. We compared our data with previous studies for the periods 1982-1997 and 1997-2001, respectively. METHODS: The material was collected from the aeromedical section's archive...
February 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28074593/microtubule-associated-protein-1b-novel-paraneoplastic-biomarker
#14
Avi Gadoth, Thomas J Kryzer, Jim Fryer, Andrew McKeon, Vanda A Lennon, Sean J Pittock
OBJECTIVE: To report the identification of microtubule-associated protein (MAP) 1B as the antigen of the previously described Purkinje cell cytoplasmic antibody type 2 (PCA-2) antibody, its frequency, and clinical, oncological, and serological associations. METHODS: Archival serum or cerebrospinal fluid (CSF) specimens were available from 96 of 118 consecutive PCA-2-IgG-seropositive patients identified during 1993-2016. The autoantigen, defined in mouse brain lysate by Western blot and mass spectrometry, was confirmed by dual immunohistochemical staining using commercial antibodies...
February 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28054528/brain-metastasis-from-nonnasopharyngeal-head-and-neck-squamous-cell-carcinoma-a-case-series-and-review-of-literature
#15
REVIEW
Sarbani Ghosh-Laskar, Jai Prakash Agarwal, Prahlad H Yathiraj, Prasad Tanawade, Rajendra Panday, Tejpal Gupta, Ashwini Budrukkar, Vedang Murthy
BACKGROUND: Brain metastasis from primary head and neck squamous cell carcinoma (HNSCC) is infrequent and probably under-reported thereby leading to paucity of information. METHODS: Archives of two institutes in India were studied from 2005 to 2013 and relevant information regarding patient demographics, treatment details, and follow-up was obtained for patients having brain metastasis (BM) from HNSCC. Data were analyzed using SPSS software version 20 (IBM Corporation, NY, USA)...
July 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/27991555/simple-reverse-genetics-systems-for-asian-and-african-zika-viruses
#16
Thérèse Atieh, Cécile Baronti, Xavier de Lamballerie, Antoine Nougairède
Zika virus (ZIKV), a typical example of a re-emerging pathogen, recently caused large outbreaks in Pacific islands and the Americas, associated with congenital diseases and neurological complications. Deciphering the natural history, ecology and pathophysiology of this mosquito-borne pathogen requires effective reverse genetics tools. In the current study, using the bacterium-free 'Infectious Subgenomic Amplicons' (ISA) method, we generated and made available to the scientific community via the non-profit European Virus Archive collection, two simple and performing reverse genetics systems for ZIKV...
December 19, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27943207/quantitative-analysis-of-exosomal-mirna-via-qpcr-and-digital-pcr
#17
Shayne A Bellingham, Mitch Shambrook, Andrew F Hill
Extracellular vesicles, such as exosomes and microvesicles, have been shown to contain potential microRNA (miRNA) biomarkers that may be utilized in the diagnosis of various diseases from cancer to neurological disorders. The unique nature of the extracellular vesicle bilayer allows miRNA to be protected from degradation making it an ideal source of material for biomarkers discovery from both fresh and archived samples. Here we describe the quantitative analysis of miRNA isolated from exosomes by quantitative PCR and digital PCR...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27919862/spinal-cord-injury-assessing-tolerability-and-use-of-combined-rehabilitation-and-neuroaid-saturn-study-protocol-of-an-exploratory-study-in-assessing-the-safety-and-efficacy-of-neuroaid-amongst-people-who-sustain-severe-spinal-cord-injury
#18
Ramesh Kumar, Ohnmar Htwe, Azmi Baharudin, Mohammad Hisam Ariffin, Shaharuddin Abdul Rhani, Kamalnizat Ibrahim, Aishah Rustam, Robert Gan
BACKGROUND: Spinal cord injury (SCI) is a devastating condition with limited therapeutic options despite decades of research. Current treatment options include use of steroids, surgery, and rehabilitation. Nevertheless, many patients with SCI remain disabled. MLC601 (NeuroAiD), a combination of natural products, has been shown to be safe and to aid neurological recovery after brain injuries and may have a potential role in improving recovery after SCI. OBJECTIVE: The aim of this study is to evaluate the safety and efficacy of NeuroAiD amongst people who sustain SCI in the study setting...
December 5, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27902445/focus-issue-new-horizons-for-treating-neurological-disease
#19
EDITORIAL
Leslie K Ferrarelli
This issue of Science Signaling highlights research that uncovers protein interaction networks and potential drug targets, as well as research that identifies molecular mechanisms of action of novel or existing drugs, for neurological and psychological disease. This Editorial Guide features a handful of papers from 2016 that join the ranks of Science Signaling's vast archive of articles related to neuroscience.
November 15, 2016: Science Signaling
https://www.readbyqxmd.com/read/27884576/extracorporeal-life-support-for-refractory-cardiac-arrest-from-accidental-hypothermia-a-10-year-experience-in-edinburgh
#20
Maziar Khorsandi, Scott Dougherty, Neil Young, Dean Kerslake, Vincenzo Giordano, Robert Lendrum, William Walker, Vipin Zamvar, Ivan Yim, Renzo Pessotto
BACKGROUND: Cardiac arrest caused by accidental hypothermia is a rare phenomenon with a significant mortality rate if untreated. The consensus is that these patients should be rewarmed with extracorporeal life support (ECLS) with the potential for excellent survival and neurologic outcomes. However, given the lack of robust data and clinical trials, the optimal management of such patients remains elusive. OBJECTIVE: In this single-center study, we looked at the outcomes of all adult patients undergoing salvage ECLS for cardiac arrest caused by accidental hypothermia over a 10-year period from June 2006 to June 2016...
February 2017: Journal of Emergency Medicine
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