Jue-Sheng Ong, Mathias Seviiri, Jean Claude Dusingize, Yeda Wu, Xikun Han, Jianxin Shi, Catherine M Olsen, Rachel E Neale, John F Thompson, Robyn P M Saw, Kerwin F Shannon, Graham J Mann, Nicholas G Martin, Sarah E Medland, Scott D Gordon, Richard A Scolyer, Georgina V Long, Mark M Iles, Maria Teresa Landi, David C Whiteman, Stuart MacGregor, Matthew H Law
Male-pattern baldness (MPB) is related to dysregulation of androgens such as testosterone. A previously observed relationship between MPB and skin cancer may be due to greater exposure to ultraviolet radiation or indicate a role for androgenic pathways in the pathogenesis of skin cancers. We dissected this relationship via Mendelian randomization (MR) analyses, using genetic data from recent male-only meta-analyses of cutaneous melanoma (12,232 cases; 20,566 controls) and keratinocyte cancers (KCs) (up to 17,512 cases; >100,000 controls), followed by stratified MR analysis by body-sites...
October 3, 2023: Nature Communications