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Dileep Krishnamoorthy Srinivas, Mahesha Kanthila, Rama Prakasha Saya, Jvs Vidyasagar
INTRODUCTION: Bone tunnel enlargement after Anterior Cruciate Ligament Reconstruction (ACL-R) is a well-accepted phenomenon but there are very few published data comparing the extent of tunnel widening by various methods of fixation after ACL-R. AIM: To compare the femoral and tibial tunnel widening following ACL-R with different methods of fixation using CT scan. MATERIALS AND METHODS: This one year prospective study included all patients with chronic Anterior Cruciate Ligament (ACL) injury who underwent primary arthroscopic ACL-R using tripled hamstring tendon autograft...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
Yijing Liu, Xiangyu Yang, Zhiqi Huang, Peng Huang, Yang Zhang, Lin Deng, Zhantong Wang, Zijian Zhou, Yi Liu, Heather Kalish, Niveen M Khachab, Xiaoyuan Chen, Zhihong Nie
Magneto-plasmonic Janus vesicles (JVs) integrated with gold nanoparticles (AuNPs) and magnetic NPs (MNPs) were prepared asymmetrically in the membrane for in vivo cancer imaging. The hybrid JVs were produced by coassembling a mixture of hydrophobic MNPs, free amphiphilic block copolymers (BCPs), and AuNPs tethered with amphiphilic BCPs. Depending on the size and content of NPs, the JVs acquired spherical or hemispherical shapes. Among them, hemispherical JVs containing 50 nm AuNPs and 15 nm MNPs showed a strong absorption in the near-infrared (NIR) window and enhanced the transverse relaxation (T2 ) contrast effect, as a result of the ordering and dense packing of AuNPs and MNPs in the membrane...
December 5, 2016: Angewandte Chemie
Usha Shalini P, Tanya Debnath, Vidyasagar Jvs, Lakshmi K Kona, Suguna R Kamaraju, Ravindranath Kancherla, Lakshmi K Chelluri
There is an increasing evidence suggesting the role of fork head boxP3 (FoxP3) in the development and the regulation of CD4(+)CD25(+) Treg cells. T-cell regulatory mechanisms in rheumatoid arthritis patients were evaluated by the contributing factors such as pro-inflammatory cytokines, circulating immune complexes, HLA DR expression, ligand binding biomarkers, FoxP3 expression in paired samples of peripheral blood (PB) and synovial fluid (SF). These cellular responses were further correlated with the humoral immune responses such as anti-cyclic citrullinated peptides IgG (CCP), circulating immune complex-c1q IgG (CIC), immunoglobulin G (IgG) and immunoglobulin M (IgM) of the rheumatoid arthritis factor (RAF)...
2015: Central-European Journal of Immunology
Maheshwar Lakkireddy, Dhanraj Bedarakota, Jvs Vidyasagar, Sivaprasad Rapur, Madhulatha Karra
INTRODUCTION: Osteoarthritis (OA) is the most common degenerative joint disorder leading to functional impairment and dependency in older adults. Early detection and intervention is of paramount importance in decreasing the morbidity. Radiography is the first investigation of choice for OA patients presenting with knee pain. But, there is a high degree of discordance between clinical and radiographic findings. Arthroscopy aids in accurate diagnosis of OA knee. AIM: In view of the conflicting reports in the literature the present study was undertaken to report the correlation among radiographic, arthroscopic and pain findings in knee OA patients to facilitate early and precise diagnosis...
December 2015: Journal of Clinical and Diagnostic Research: JCDR
Samantha L Isenberg, Melissa D Carter, Leigh Ann Graham, Thomas P Mathews, Darryl Johnson, Jerry D Thomas, James L Pirkle, Rudolph C Johnson
Ingestion of soapberry fruit toxins hypoglycin A and methylenecyclopropylglycine has been linked to public health challenges worldwide. In 1976, over 100 years after Jamaican vomiting sickness (JVS) was first reported, the cause of JVS was linked to the ingestion of the toxin hypoglycin A produced by ackee fruit. A structural analogue of hypoglycin A, methylenecyclopropylglycine (MCPG), was implicated as the cause of an acute encephalitis syndrome (AES). Much of the evidence linking hypoglycin A and MCPG to these diseases has been largely circumstantial due to the lack of an analytical method for specific metabolites...
September 21, 2015: Chemical Research in Toxicology
B Bergamaschi, M T Rodrigues, J V S Silva, M Kluge, R B Luz, J D Fleck, E Bianchi, L B Silva, F R Spilki
It is well recognized that the classical biological and chemical markers of environmental pollution do not necessarily indicate the presence or absence of emerging threats to public health, such as waterborne viruses and genotoxicants. The purpose of this preliminary study was to evaluate the presence of material of enteroviruses (EV), rotavirus (RV) and adenovirus (AdV) and genotoxicity in water samples from points of routine monitoring of water quality in the main course of the Sinos River. The points are classified into different levels of pollution in accordance to the Brazilian federal regulations...
May 2015: Brazilian Journal of Biology, Revista Brasleira de Biologia
Andrea Felser, Andrea Stoller, Réjane Morand, Dominik Schnell, Massimiliano Donzelli, Luigi Terracciano, Jamal Bouitbir, Stephan Krähenbühl
Dronedarone is an amiodarone-like antiarrhythmic drug associated with severe liver injury. Since dronedarone inhibits mitochondrial respiration and β-oxidation in vitro, mitochondrial toxicity may also explain dronedarone-associated hepatotoxicity in vivo. We therefore studied hepatotoxicity of dronedarone (200mg/kg/day for 2 weeks or 400mg/kg/day for 1 week by intragastric gavage) in heterozygous juvenile visceral steatosis (jvs(+/-)) and wild-type mice. Jvs(+/-) mice have reduced carnitine stores and are sensitive for mitochondrial β-oxidation inhibitors...
September 2, 2014: Toxicology
Y Takahashi, M-B Luo, T Nishizaki, N Kobayashi, X Hu
Because of the commensurability condition between the vortex lattice constant determined by external magnetic field and the nano-scale layered structure, interlayer Josephson vortices (JVs) in high-Tc cuprate superconductors can take various configurations. We have simulated with Langevin scheme the in-plane flux-flow dynamics of JVs subject to point-like pinning centers. Oscillation in resistivity is found with the applied magnetic field, where the resistivity peaks occur around commensurate JV configurations...
April 2014: Journal of Nanoscience and Nanotechnology
Jitesh K Jain, J V S Vidyasagar, Radha Sagar, Hiren Patel, Matad Lokeshwaraiah Chetan, Ashish Bajaj
PURPOSE: The aim of this study was to evaluate the long-term results of arthroscopic excision of pigmented villonodular synovitis (PVNS) of the knee joint. METHODS: We retrospectively assessed the results of arthroscopic excision of PVNS done in 40 patients from 1987 to 2012 by the senior author (JVS). No radiotherapy was given to any patient. All patients were followed for a mean of seven years. At follow-up functional assessment was done using the Lysholm score...
December 2013: International Orthopaedics
Marc S Penn, Farrell O Mendelsohn, Gary L Schaer, Warren Sherman, Maryjane Farr, Joseph Pastore, Didier Rouy, Ruth Clemens, Rahul Aras, Douglas W Losordo
RATIONALE: Preclinical studies indicate that adult stem cells induce tissue repair by activating endogenous stem cells through the stromal cell-derived factor-1:chemokine receptor type 4 axis. JVS-100 is a DNA plasmid encoding human stromal cell-derived factor-1. OBJECTIVE: We tested in a phase 1, open-label, dose-escalation study with 12 months of follow-up in subjects with ischemic cardiomyopathy to see if JVS-100 improves clinical parameters. METHODS AND RESULTS: Seventeen subjects with ischemic cardiomyopathy, New York Heart Association class III heart failure, with an ejection fraction ≤40% on stable medical therapy, were enrolled to receive 5, 15, or 30 mg of JVS-100 via endomyocardial injection...
March 1, 2013: Circulation Research
Ikumi Tamai
The carnitine/organic cation transporter (OCTN) family consists of three transporter isoforms, i.e. OCTN1 (SLC22A4) and OCTN2 (SLC22A5) in humans and animals and Octn3 (Slc22a21) in mice. These transporters are physiologically essential to maintain appropriate systemic and tissue concentrations of carnitine by regulating its membrane transport during intestinal absorption, tissue distribution and renal reabsorption. Among them, OCTN2 is a sodium-dependent, high-affinity transporter of carnitine, and a functional defect of OCTN2 due to genetic mutation causes primary systemic carnitine deficiency (SCD)...
January 2013: Biopharmaceutics & Drug Disposition
Takeo Nakanishi, Yoko Fukuyama, Masaharu Fujita, Yoshiyuki Shirasaka, Ikumi Tamai
To study transport of the carnitine precursor gamma-butyrobetaine (GBB) by rat liver-specific GABA transporter 2 (rGat2), we measured the uptake of deuterated GBB (d(3)-GBB) by Xenopus oocytes expressing rGat2. rGat2-mediated d(3)-GBB uptake was Na(+) and Cl(-) dependent, and was saturable with a K(m) value of 70.6 ± 34.8 µM. In carnitine transporter Octn2-deficient Jvs mice, mRNA expression of mGat3, the mouse ortholog of GAT2, decreased in liver, but increased in brain, while mRNA expression of mBbox1, which hydroxylates GBB to carnitine, increased in kidney and brain...
2011: Drug Metabolism and Pharmacokinetics
Joseph J Ricotta, Catalin Harbuzariu, Juan N Pulido, Thomas C Bower, Manju Kalra, Peter Gloviczki
The Publisher regrets that this article is an accidental duplication of an article that has already been published, doi: 10.1016/j.jvs.2011.10.003. The duplicate article has therefore been withdrawn.
May 28, 2011: Journal of Vascular Surgery
Kiyokazu Ozaki, Tomoya Sano, Naho Tsuji, Tetsuro Matsuura, Isao Narama
The juvenile visceral steatosis (JVS) mouse is a mutant strain with an inherited systemic carnitine deficiency. Mice of this strain show clinical signs attributable to impaired heat production and disturbed energy production. Brown adipose tissue (BAT) is the primary site of non-shivering thermogenesis in the presence of uncoupling protein-1 (UCP-1) in rodents and humans, especially in infants. To investigate the possible cause of impaired heat production in BAT, we studied the morphological features, carnitine concentration, and UCP-1 production of BAT in JVS mice...
May 2011: Laboratory Investigation; a Journal of Technical Methods and Pathology
Miharu Ushikai, Masahisa Horiuchi, Keiko Kobayashi, Sadayuki Matuda, Akio Inui, Toru Takeuchi, Takeyori Saheki
Pyruvate dehydrogenase kinase 4 (PDK4) mRNA has been reported as an up-regulated gene in the heart and skeletal muscle of carnitine-deficient juvenile visceral steatosis (JVS) mice under fed conditions. PDK4 plays an important role in the inhibition of glucose oxidation via the phosphorylation of pyruvate dehydrogenase complex (PDC). This study evaluated the meaning of increased PDK4 mRNA in glucose metabolism by investigating PDK4 protein levels, PDC activity and glucose uptake by the heart and skeletal muscle of JVS mice...
March 2011: Molecular Genetics and Metabolism
G Lauria, S T Hsieh, O Johansson, W R Kennedy, J M Leger, S I Mellgren, M Nolano, I S J Merkies, M Polydefkis, A G Smith, C Sommer, J Valls-Solé
BACKGROUND: Revision of the guidelines on the use of skin biopsy in the diagnosis of peripheral neuropathy, published in 2005, has become appropriate owing to publication of more relevant articles. Most of the new studies focused on small fiber neuropathy (SFN), a subtype of neuropathy for which the diagnosis was first developed through skin biopsy examination. This revision focuses on the use of this technique to diagnose SFN. METHODS: Task force members searched the Medline database from 2005, the year of the publication of the first EFNS guideline, to June 30th, 2009...
July 2010: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
(no author information available yet)
Revision of the guidelines on the use of skin biopsy in the diagnosis of peripheral neuropathy, published in 2005, has become appropriate due to publication of more relevant papers. Most of the new studies focused on small fiber neuropathy (SFN), a subtype of neuropathy for which the diagnosis was first developed through skin biopsy examination. This revision focuses on the use of this technique to diagnose SFN. Task force members searched the Medline database from 2005, the year of the publication of the first EFNS guideline, to June 30(th), 2009...
June 2010: Journal of the Peripheral Nervous System: JPNS
Sayaka Kato, Yukio Kato, Tadakatsu Nakamura, Tomoko Sugiura, Yoshiyuki Kubo, Yoshiharu Deguchi, Akira Tsuji
Carnitine/organic cation transporter 2 (OCTN2) recognizes various cationic compounds as substrates in vitro, but information on its pharmacokinetic role in vivo is quite limited. This paper demonstrates altered tissue distribution of the OCTN2 substrate pyrilamine in juvenile visceral steatosis (jvs) mice, which have a hereditary defect of the octn2 gene. At 30 min after intravenous injection of pyrilamine, the tissue-to-plasma concentration ratio (K(p)) in the heart and pancreas was higher, whereas the K(p) in kidney and testis was lower in jvs mice compared with wild-type mice...
December 2009: Biopharmaceutics & Drug Disposition
Takeo Sakoguchi, Masahisa Horiuchi, Akihiro Asakawa, Miharu Ushikai, Goichiro Yoshida, Mineko Fujimiya, Ikuo Kato, Masamitsu Nakazato, Toru Takeuchi, Takeyori Saheki, Akio Inui
Carnitine-deficient juvenile visceral steatosis (JVS) mice, suffering from fatty acid metabolism abnormalities, have reduced locomotor activity after fasting. We examined whether JVS mice exhibit specific defect in the feeding response to fasting, a key process of anti-famine homeostatic mechanism. Carnitine-deficient JVS mice showed grossly defective feeding response to 24 h-fasting, with almost no food intake in the first 4 h, in marked contrast to control animals. JVS mice also showed defective acyl-ghrelin response to fasting, less suppressed leptin, and seemingly normal corticotropin-releasing factor (CRF) expression in the hypothalamus despite markedly increased plasma corticosterone...
November 2009: Biochimica et Biophysica Acta
Takashi Kano, Yukio Kato, Kimihiro Ito, Takuo Ogihara, Yoshiyuki Kubo, Akira Tsuji
Carnitine/organic cation transporter (OCTN) 2 (SLC22A5) plays a pivotal role in renal tubular reabsorption of carnitine, a vitamin-like compound, on apical membranes of proximal tubules, but its role in relation to therapeutic drugs remains to be clarified. The purpose of the present study was to elucidate the involvement of OCTN2 in renal disposition of a beta-lactam antibiotic, cephaloridine (CER), based on experiments with juvenile visceral steatosis (jvs) mice, which have a functional deficiency of the octn2 gene...
May 2009: Drug Metabolism and Disposition: the Biological Fate of Chemicals
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