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https://www.readbyqxmd.com/read/29753565/spanish-language-screening-scales-a-critical-review
#1
S Torres-Castro, B Mena-Montes, G González-Ambrosio, A Zubieta-Zavala, N M Torres-Carrillo, G I Acosta-Castillo, M C Espinel-Bermúdez
INTRODUCTION: Dementia is a chronic, degenerative disease with a strong impact on families and health systems. The instruments currently in use for measuring cognitive impairment have different psychometric characteristics in terms of application time, cut-off point, reliability, and validity. The objective of this review is to describe the characteristics of the validated, Spanish-language versions of the Mini-Cog, Clock-Drawing Test, and Mini-Mental State Examination scales for cognitive impairment screening...
May 9, 2018: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/29692001/all-cause-and-cause-specific-mortality-in-granulomatosis-with-polyangiitis-a-population-based-study
#2
Ju Ann Tan, Hyon K Choi, Hui Xie, Eric C Sayre, John M Esdaile, J Antonio Aviña-Zubieta
OBJECTIVE: To investigate all-cause and cause-specific mortality in patients with newly diagnosed granulomatosis with polyangiitis (GPA) between two calendar time periods, 1997-2004 and 2005-2012. METHODS: Using an administrative health database, we compared all incident cases of GPA to non-GPA controls matched based on sex, age and entry time. Study cohorts were divided into two sub-groups based on the year of diagnosis (i.e., early cohort 1997-2004 and late cohort 2005-2012)...
April 25, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29683943/pentoxifylline-added-to-steroid-window-treatment-phase-modified-apoptotic-gene-expression-in-pediatric-patients-with-acute-lymphoblastic-leukemia
#3
Jesus Meza-Arroyo, Alejandro Bravo-Cuellar, Luis Felipe Jave-Suárez, Georgina Hernández-Flores, Pablo Ortiz-Lazareno, Adriana Aguilar-Lemarroy, Marlin Padilla-Corona, Fernando Sanchez-Zubieta, Oscar Gonzalez-Ramella
Pentoxifylline is a xanthine that possesses antitumor properties and that can induce higher apoptosis in the leukemic cells of pediatric patients with acute lymphoblastic leukemia (ALL) during treatment with prednisone. We conducted a phase 1 pilot, controlled, randomized trial to evaluate the gene expression modified by pentoxifylline during the steroid window of induction to remission phase in patients newly diagnosed with ALL. Experimental and control treatments induced broad changes in the gene expression profile...
April 20, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29681324/expectancy-modulation-of-opioid-neurotransmission
#4
Marta Pecina, Jon-Kar Zubieta
Expectancies are powerful modulators of cognitive and emotional experiences, as well as the neurobiological responses linked to these processes. In medicine, placebo effects are a clear example of how expectancies activate opioid neurotransmission in a treatment context, leading to the experience of analgesia and the improvement of emotional states, among other symptoms. Molecular neuroimaging techniques using positron emission tomography (PET) and the selective μ-opioid receptor tracer [11 C]carfentanil have significantly contributed to our understanding of the neurobiological systems involved in the formation of placebo effects...
2018: International Review of Neurobiology
https://www.readbyqxmd.com/read/29665755/incremental-direct-medical-costs-of-systemic-lupus-erythematosus-patients-in-the-years-preceding-diagnosis-a-general-population-based-study
#5
N McCormick, C A Marra, M Sadatsafavi, J A Aviña-Zubieta
Objective We estimated the incremental (extra) direct medical costs of a population-based cohort of newly diagnosed systemic lupus erythematosus (SLE) for five years before and after diagnosis, and the impact of sex and socioeconomic status (SES) on pre-index costs for SLE. Methods We identified all adults newly diagnosed with SLE over 2001-2010 in British Columbia, Canada, and obtained a sample of non-SLE individuals from the general population, matched on sex, age, and calendar-year of study entry. We captured costs for all outpatient encounters, hospitalisations, and dispensed medications each year...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29648677/excess-productivity-costs-of-systemic-lupus-erythematosus-systemic-sclerosis-and-sjogren-s-syndrome-a-general-population-based-study
#6
Natalie McCormick, Carlo A Marra, Mohsen Sadatsafavi, Jacek A Kopec, J Antonio Aviña-Zubieta
OBJECTIVE: Determine excess productivity losses and costs of systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and Sjogren's syndrome (SjS) at the population level. METHODS: Administrative databases from the province of British Columbia, Canada, were used to establish population-based cohorts of SLE, SSc, and SjS, and matched comparison cohorts selected from the general population. Random samples from these cohorts were surveyed about time absent from paid and unpaid work, and working at reduced levels/efficiency (presenteeism), using validated labour questionnaires...
April 12, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29589696/-palliative-care-pathways-of-older-patients
#7
Lourdes Zubieta, Réjean Hébert, Michel Raîche
INTRODUCTION: To determine the palliative care pathways of older patients in Sherbrooke, Qc by examining their transfers to other facilities. METHODS: This analysis was conducted by linking 3 databases: emergency department, hospitalizations and nursing homes. The study period ranged from January 2011 to December 2015. SPSS was used for statistical analysis. The study only included palliative care patients. RESULTS: 25% of patients waited less than 7 days for transfer, and 74% waited less than 3 weeks...
January 2018: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/29562355/tetramerization-of-mads-family-transcription-factors-sepallata3-and-agamous-is-required-for-floral-meristem-determinacy-in-arabidopsis
#8
Véronique Hugouvieux, Catarina S Silva, Agnès Jourdain, Arnaud Stigliani, Quentin Charras, Vanessa Conn, Simon J Conn, Cristel C Carles, François Parcy, Chloe Zubieta
The MADS transcription factors (TF) constitute an ancient family of TF found in all eukaryotes that bind DNA as obligate dimers. Plants have dramatically expanded the functional diversity of the MADS family during evolution by adding protein-protein interaction domains to the core DNA-binding domain, allowing the formation of heterotetrameric complexes. Tetramerization of plant MADS TFs is believed to play a central role in the evolution of higher plants by acting as one of the main determinants of flower formation and floral organ specification...
March 19, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29560918/meta-analysis-of-neural-effects-of-depression-therapies
#9
Jon-Kar Zubieta
No abstract text is available yet for this article.
May 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29555382/individuals-with-more-severe-depression-fail-to-sustain-nucleus-accumbens-activity-to-preferred-music-over-time
#10
Lisanne M Jenkins, Kristy A Skerrett, Sophie R DelDonno, Víctor G Patrón, Kortni K Meyers, Scott Peltier, Jon-Kar Zubieta, Scott A Langenecker, Monica N Starkman
We investigated the ability of preferred classical music to activate the nucleus accumbens in patients with Major depressive disorder (MDD). Twelve males with MDD and 10 never mentally ill male healthy controls (HC) completed measures of anhedonia and depression severity, and listened to 90-second segments of preferred classical music during fMRI. Compared to HCs, individuals with MDD showed less activation of the left nucleus accumbens (NAcc). Individuals with MDD showed attenuation of the left NAcc response in later compared to earlier parts of the experiment, supporting theories that MDD involves an inability to sustain reward network activation...
March 5, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29547816/abnormal-emotional-and-neural-responses-to-romantic-rejection-and-acceptance-in-depressed-women
#11
Ashley A Yttredahl, Erin McRobert, Benjamin Sheler, Brian J Mickey, Tiffany M Love, Scott A Langenecker, Jon-Kar Zubieta, David T Hsu
INTRODUCTION: Responding adaptively to one's social environment is a key factor predicting the course of major depressive disorder (MDD). Socially rejecting events can exacerbate, whereas socially accepting events can ameliorate depressive symptoms. The neural responses to rejection and acceptance in MDD are relatively unexplored. METHODS: We used functional magnetic resonance imaging (fMRI) to measure neural responses to romantic rejection and acceptance in women diagnosed with current MDD (n = 19) and a matched group of healthy controls (HCs) (n = 19)...
July 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29529826/theoretical-analysis-of-single-cycle-self-compression-of-near-infrared-pulses-using-high-spatial-modes-in-capillary-fibers
#12
Boris A López-Zubieta, Enrique Conejero Jarque, Íñigo J Sola, Julio San Roman
Soliton self-compression is demonstrated during the propagation of high spatial modes in hollow core fibers in the near-infrared spectral region, taking advantage of their negative dispersion response. We have found that there is always an optimum spatial mode to observe this phenomenon, compressing the pulses down to the single-cycle regime without needing any external compression device and with a consequent increase in the output peak power. Our result is relevant for any ultrashort laser application in which few- or single-cycle pulses are crucial...
March 5, 2018: Optics Express
https://www.readbyqxmd.com/read/29448964/utility-of-rituximab-treatment-for-exophthalmos-myxedema-and-osteoarthropathy-syndrome-resistant-to-corticosteroids-due-to-graves-disease-a-case-report
#13
Aldo Ferreira-Hermosillo, Ruben Casados-V, Pedro Paúl-Gaytán, Victoria Mendoza-Zubieta
BACKGROUND: Exophthalmos, myxedema, and osteoarthropathy syndrome is a very rare condition that is associated with Graves' disease. The presence of dermopathy and the involvement of joint/bone tissues indicate that it seems to be related with the severity of the autoimmune process. Owing to its low incidence, there is a lack of information regarding its treatment and clinical follow-up. Some cases improved after use of high doses of steroids; however, some patients do not respond to this treatment...
February 16, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29414433/il-6-expression-is-correlated-with-increased-t-cell-proliferation-and-survival-in-the-arterial-wall-in-giant-cell-arteritis
#14
Sukhbir Manku, Wendy Wong, Zongshu Luo, Michael A Seidman, Zainab Alabdurubalnabi, Kevin Rey, Winnie Enns, J Antonio Avina-Zubieta, Kamran Shojania, Jonathan C Choy
Giant cell arteritis (GCA) is the most common vasculitis in adults affecting large and medium-sized arteries. IL-6 and T cell accumulation within the arterial wall contribute to the pathogenesis of GCA, and blockade of IL-6 activity is efficacious in its treatment. We examined the relationship between levels of IL-6 expression and immunological processes that control the expansion of T cells in GCA-positive temporal artery biopsies. CD4 T cells accumulated in clusters within the media and deep intima of all GCA lesions...
March 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29361284/intraoperative-3-tesla-magnetic-resonance-imaging-our-experience-in-tumors
#15
A García-Baizán, A Tomás-Biosca, P Bartolomé Leal, P D Domínguez, R García de Eulate Ruiz, S Tejada, J L Zubieta
OBJECTIVE: To report our experience in the use of 3 tesla intraoperative magnetic resonance imaging (MRI) in neurosurgical procedures for tumors, and to evaluate the criteria for increasing the extension of resection. MATERIAL AND METHODS: This retrospective study included all consecutive intraoperative MRI studies done for neuro-oncologic disease in the first 13 months after the implementation of the technique. We registered possible immediate complications, the presence of tumor remnants, and whether the results of the intraoperative MRI study changed the surgical management...
March 2018: Radiología
https://www.readbyqxmd.com/read/29316319/protein-profile-in-aspergillus-nidulans-recombinant-strains-overproducing-heterologous-enzymes
#16
Mariane Paludetti Zubieta, Fabiano Jares Contesini, Marcelo Ventura Rubio, Any Elisa de Souza Schmidt Gonçalves, Jaqueline Aline Gerhardt, Rolf Alexander Prade, André Ricardo de Lima Damasio
Filamentous fungi are robust cell factories and have been used for the production of large quantities of industrially relevant enzymes. However, the production levels of heterologous proteins still need to be improved. Therefore, this article aimed to investigate the global proteome profiling of Aspergillus nidulans recombinant strains in order to understand the bottlenecks of heterologous enzymes production. About 250, 441 and 424 intracellular proteins were identified in the control strain Anid_pEXPYR and in the recombinant strains Anid_AbfA and Anid_Cbhl respectively...
March 2018: Microbial Biotechnology
https://www.readbyqxmd.com/read/29213156/gastroesophageal-reflux-disease-in-patients-with-long-standing-type-1-diabetes-mellitus-utility-of-two-self-report-questionnaires-in-a-multifactorial-disease
#17
COMPARATIVE STUDY
Emmanuel Marin Valdez-Solis, Claudia Ramírez-Rentería, Aldo Ferreira-Hermosillo, Mario Molina-Ayala, Victoria Mendoza-Zubieta, Víctor Rodríguez-Pérez
Background: Gastroesophageal pathologies are common and multifactorial in patients with type 1 diabetes (T1DM). The evaluation with endoscopy and 24 h pH esophageal monitoring is expensive and not always available in all medical centers, especially in developing countries so more cost-effective algorithms for diagnosis are required. Clinical questionnaires are easy to apply but its utility for gastroesophageal reflux disease screening in patients with long standing T1DM must be analyzed...
September 30, 2017: Colombia Médica: CM
https://www.readbyqxmd.com/read/29193936/-evaluation-of-cardiovascular-risk-factors-in-obesity-before-and-after-bariatric-surgery
#18
Karla Leticia Sánchez-Ruiz, Aldo Ferreira-Hermosillo, Mario Antonio Molina-Ayala, Claudia Ramírez-Rentería, Victoria Mendoza-Zubieta
BACKGROUND: Mexico has one of the highest prevalences of severe obesity worldwide. Mortality in those patients may be as high as 90% mainly due to cardiovascular disease. Despite Framingham score has been validated in the Mexican population, it only predicts cardiovascular risk at 10 years. Meanwhile ASCVD10 score could evaluate risk at 10 years and through lifetime. None of these scores have been used for cardiovascular risk assessment in Mexican patients with severe obesity. METHODS: We conducted a quasi-experimental (before/ after) study with 109 patients with severe obesity, assessed prevalence of comorbidities, performed anthropometric and biochemical evaluations before and a year after bariatric surgery...
September 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29130701/patient-generated-subjective-global-assessment-of-nutritional-status-in-pediatric-patients-with-recent-cancer-diagnosis
#19
Mayra Jezabel Vázquez de la Torre, Katja Stein, Edgar Manuel Vásquez Garibay, Miguel Roberto Kumazawa Ichikawa, Rogelio Troyo Sanromán, Alicia Guadalupe Salcedo Flores, Fernando Antonio Sánchez Zubieta
BACKGROUND: The subjective global assessment (SGA) is a simple, sensitive tool used to identify nutritional risk. It is widely used in the adult population, but there is little evidence on its effectiveness in children with cancer. OBJECTIVE: This cross-sectional study was undertaken to demonstrate significant correlation between a simplified version of the Patient-Generated SGA (PG-SGA) and anthropometric assessment to identify nutritional status in children recently diagnosed with cancer...
October 24, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29104953/exploring-the-multiligand-binding-specificity-of-saposin-b-reveals-two-binding-sites
#20
Jay Tinklepaugh, Britannia M Smith, Etta Hanlon, Chloe Zubieta, Fadi Bou-Abdallah, Robert P Doyle
Saposin B (SapB) is a human lysosomal protein, critical for the degradation of O -sulfogalactosylceramide (sulfatide). SapB binds sulfatide and presents it to the active site of the enzyme arylsulfatase A. Deficiency of SapB leads to fatal activator-deficient metachromatic leukodystrophy. Given the conformational flexibility and the large hydrophobic "pocket" produced upon (physiologically relevant) homodimerization, SapB may have broader substrate diversity than originally thought. Herein, we present evidence using fluorescence spectroscopy and computational docking studies that SapB binds a wide variety of ligands at K D values varying from micromolar to nanomolar, with entropy being the primary driving force...
October 31, 2017: ACS Omega
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