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Salma Al-Karmi, Silvia A Albu, Alyssa Vito, Nancy Janzen, Shannon Czorny, Laura Banevicius, Max Nanao, Jon Zubieta, Alfredo Capretta, John F Valliant
Hydrocyanine dyes are sensitive "turn-on" type optical probes that can detect reactive oxygen species (ROS). We have developed a method to prepare an 18F-labeled hydrocyanine dye as a multi-modal PET and optical "turn-on" probe. A commercially available NIR dye was modified with a fluorinated prosthetic group that did not alter its ROS sensing properites in the presence of superoxide and hydroxyl radicals. The 18F-labeled analogue was produced using a single step terminal fluorination procedure. PET imaging and quantitative in vivo biodistribution studies indicated this novel probe had remarkably different pharmacokinetics compared to the oxidized cyanine analogue...
October 21, 2016: Chemistry: a European Journal
Gustavo Zubieta-Calleja, Natalia Zubieta-DeUrioste, Poul-Erik Paulev
No abstract text is available yet for this article.
September 2016: High Altitude Medicine & Biology
Alison Berent-Spillson, Courtney Marsh, Carol Persad, John Randolph, Jon-Kar Zubieta, Yolanda Smith
Disturbances of emotion regulation and depressive symptoms are common during the menopause transition. Reproductive hormone levels are not directly correlated with depressive symptoms, and other factors may influence mood symptoms during menopause. In this study, we sought to determine the role of metabolic function in mood symptoms during menopause, hypothesizing an association with menopause status and long-term glucose load. We studied 54 women across three menopause transition stages (15 premenopause, 11 perimenopause, and 28 postmenopause), examining effects of age, hormones, and metabolism on mood and neural activation during emotional discrimination...
September 5, 2016: Psychoneuroendocrinology
Brian J Mickey, Joseph Heffernan, Curtis Heisel, Marta Peciña, David T Hsu, Jon-Kar Zubieta, Tiffany M Love
RATIONALE: Oxytocin is a neuropeptide widely recognized for its role in regulating social and reproductive behavior. Increasing evidence from animal models suggests that oxytocin also modulates reward circuitry in non-social contexts, but evidence in humans is lacking. OBJECTIVES: We examined the effects of oxytocin administration on reward circuit function in 18 healthy men as they performed a monetary incentive task. METHODS: The blood oxygenation level-dependent (BOLD) signal was measured using functional magnetic resonance imaging in the context of a randomized, double-blind, placebo-controlled, crossover trial of intranasal oxytocin...
September 10, 2016: Psychopharmacology
Ulrich Zander, Michele Cianci, Nicolas Foos, Catarina S Silva, Luca Mazzei, Chloe Zubieta, Alejandro de Maria, Max H Nanao
Recent advances in macromolecular crystallography have made it practical to rapidly collect hundreds of sub-data sets consisting of small oscillations of incomplete data. This approach, generally referred to as serial crystallography, has many uses, including an increased effective dose per data set, the collection of data from crystals without harvesting (in situ data collection) and studies of dynamic events such as catalytic reactions. However, selecting which data sets from this type of experiment should be merged can be challenging and new methods are required...
September 2016: Acta Crystallographica. Section D, Structural Biology
Sharan K Rai, J Antonio Aviña-Zubieta, Natalie McCormick, Mary A De Vera, Diane Lacaille, Eric C Sayre, Hyon K Choi
OBJECTIVE: Gout and rheumatoid arthritis (RA) are the two most common forms of inflammatory arthritis worldwide. As hospitalizations for both conditions lead to substantial health resource use, contemporary inpatient trends and associated costs may provide important benchmarks of disease burden. However, relevant data are limited. METHODS: We used PopulationData BC, a population-based administrative dataset from Canada. We examined trends in the annual hospitalization and surgery rate of gout and RA from 2000-2011...
August 26, 2016: Arthritis Care & Research
Mario Molina-Ayala, Ruth Carmina Cruz-Soto, Guadalupe Vargas-Ortega, Baldomero González-Virla, Aldo Ferreira-Hermosillo, Julián Mac Gregor-Gooch, Victoria Mendoza-Zubieta
BACKGROUND: Diabetes mellitus (DM) adversely affects the skeleton and the physiological mechanisms implicated have not been explained sufficiently. Thus, the objective was to identify inflammatory cytokines (IL-1, IL-6 and TNF-alpha) in patients with T1DM and their association with markers of bone formation (sPINP) and markers of bone resorption (sCTX). METHODS: We studied 62 patients of 18 years of age or more with T1DM. We determined the values of HbA1c, vitamin D, inflammatory cytokines, as well as those of markers of bone formation and of markers of bone resorption...
2016: Revista Médica del Instituto Mexicano del Seguro Social
Mario Molina-Ayala, Antonio Rodríguez-González, Alejandra Albarrán-Sánchez, Aldo Ferreira-Hermosillo, Claudia Ramírez-Rentería, Enrique Luque-de León, Ilka Bosco-Garate, Fernando Laredo-Sánchez, Roxana Contreras-Herrera, Julián Mac Gregor-Gooch, Carlos Cuevas-García, Victoria Mendoza-Zubieta
BACKGROUND: Three percent of Mexicans suffer from morbid obesity. Comorbidities associated to this condition diminish quality of life, increase mortality and health care costs. Despite bariatric surgery has specific indications and risks, it is the only treatment with effective long-term results. The aim of the study was to evaluate biochemical and clinical patient characteristics, both preoperatively and a year after they underwent bariatric surgery. METHODS: We carried out a quasi-experimental study that evaluates a sample of patients in the Clínica de Obesidad at Hospital de Especialidades (a third level hospital) between March 2011 and October 2015...
2016: Revista Médica del Instituto Mexicano del Seguro Social
Victoria Mendoza-Zubieta, Mauricio Carvallo-Venegas, Jorge Alberto Vargas-Castilla, Nicolás Ducoing-Sisto, Alfredo Alejandro Páramo-Lovera, Lourdes Josefina Balcázar-Hernández, Julián Malcolm Mac Gregor-Gooch
Persistent primary hyperparathyroidism (PHPT) refers to the sustained hypercalcemia state detected within the first six months following parathyroidectomy. When it coexists with severe vitamin D deficiency, the effects on bone can be devastating. We report the case of a 56-year-old woman who was sent to this center because of persistent hyperparathyroidism. Her disease had over 3 years of evolution with nephrolithiasis and hip fracture. Parathyroidectomy was performed in her local unit; however, she continued with hypercalcemia, bone pain, and pathological fractures...
2016: Case Reports in Endocrinology
Marcelo Ventura Rubio, Mariane Paludetti Zubieta, João Paulo Lourenço Franco Cairo, Felipe Calzado, Adriana Franco Paes Leme, Fabio Marcio Squina, Rolf Alexander Prade, André Ricardo de Lima Damásio
BACKGROUND: The genus Aspergillus includes microorganisms that naturally degrade lignocellulosic biomass, secreting large amounts of carbohydrate-active enzymes (CAZymes) that characterize their saprophyte lifestyle. Aspergillus has the capacity to perform post-translational modifications (PTM), which provides an additional advantage for the use of these organisms as a host for the production of heterologous proteins. In this study, the N-linked glycosylation of CAZymes identified in the secretome of Aspergillus nidulans grown on lignocellulose was mapped...
2016: Biotechnology for Biofuels
Adriana Zubieta-Zavala, Guillermo Salinas-Escudero, Adrian Ramírez-Chávez, Luis García-Valladares, Malaquias López-Cervantes, Juan Guillermo López Yescas, Luis Durán-Arenas
INTRODUCTION: The increasing burden of dengue fever (DF) in the Americas, and the current epidemic in previously unaffected countries, generate major costs for national healthcare systems. There is a need to quantify the average cost per DF case. In Mexico, few data are available on costs, despite DF being endemic in some areas. Extrapolations from studies in other countries may prove unreliable and are complicated by the two main Mexican healthcare systems (the Secretariat of Health [SS] and the Mexican Social Security Institute [IMSS])...
August 2016: PLoS Neglected Tropical Diseases
Amy T Peters, Anna Van Meter, Patrick J Pruitt, Emily M Briceño, Kelly A Ryan, Melissa Hagan, Anne L Weldon, Michelle T Kassel, Aaron Vederman, Jon-Kar Zubieta, Melvin McInnis, Sara L Weisenbach, Scott A Langenecker
OBJECTIVE: Depression and bipolar disorder (negative mood disorders, NMD) are associated with dysregulated hypothalamic-pituitary-adrenal (HPA)-axis function and disrupted emotion processing. The neural networks involved in attenuation of HPA-axis reactivity overlap with the circuitry involved in perception and modulation of emotion; however, direct links between these systems are understudied. This study investigated whether cortisol activity prior to undergoing fMRI was related to neural processing of emotional information in participants with NMD...
November 2016: Psychoneuroendocrinology
Natania A Crane, Lisanne M Jenkins, Catherine Dion, Kortni K Meyers, Anne L Weldon, Laura B Gabriel, Sara J Walker, David T Hsu, Douglas C Noll, Heide Klumpp, K Luan Phan, Jon-Kar Zubieta, Scott A Langenecker
BACKGROUND: Major Depressive Disorder (MDD) and anxiety disorders often co-occur, with poorer treatment response and long-term outcomes. However, little is known about the shared and distinct neural mechanisms of comorbid MDD and anxiety (MDD+Anx). This study examined how MDD and MDD+Anx differentially impact cognitive control. METHODS: Eighteen MDD, 29 MDD+Anx, and 54 healthy controls (HC) completed the Parametric Go/No-Go (PGNG) during fMRI, including Target, Commission, and Rejection trials...
October 2016: Depression and Anxiety
Andrew Schrepf, Daniel E Harper, Steven E Harte, Heng Wang, Eric Ichesco, Johnson P Hampson, Jon-Kar Zubieta, Daniel J Clauw, Richard E Harris
Endogenous opioid system dysfunction potentially contributes to chronic pain in fibromyalgia (FM), but it is unknown if this dysfunction is related to established neurobiological markers of hyperalgesia. We previously reported that µ-opioid receptor (MOR) availability was reduced in patients with FM as compared with healthy controls in several pain-processing brain regions. In the present study, we compared pain-evoked functional magnetic resonance imaging with endogenous MOR binding and clinical pain ratings in female opioid-naive patients with FM (n = 18) using whole-brain analyses and regions of interest from our previous research...
October 2016: Pain
John H Krystal, Anissa Abi-Dargham, Schahram Akbarian, Amy F T Arnsten, Deanna M Barch, Carrie E Bearden, David L Braff, E Sherwood Brown, Edward T Bullmore, William A Carlezon, Cameron S Carter, Edwin H Cook, Zafiris Jeff Daskalakis, Ralph J DiLeone, Ronald S Duman, Anthony A Grace, Ahmad R Hariri, Paul J Harrison, Noboru Hiroi, Paul J Kenny, Joel E Kleinman, Andrew D Krystal, David A Lewis, Barbara K Lipska, Stephen R Marder, Graeme F Mason, Daniel H Mathalon, Colleen A McClung, Christopher J McDougle, Andrew M McIntosh, Francis J McMahon, Károly Mirnics, Lisa M Monteggia, Rajesh Narendran, Eric J Nestler, Alexander Neumeister, Michael C O'Donovan, Dost Öngür, Carmine M Pariante, Martin P Paulus, Godfrey Pearlson, Mary L Phillips, Daniel S Pine, Diego A Pizzagalli, Mikhail V Pletnikov, J Daniel Ragland, Judith L Rapoport, Kerry J Ressler, Scott J Russo, Gerard Sanacora, Akira Sawa, Alan F Schatzberg, Yavin Shaham, Simone G Shamay-Tsoory, Pamela Sklar, Matthew W State, Murray B Stein, Stephen M Strakowski, Stephan F Taylor, Gustavo Turecki, Bruce I Turetsky, Myrna M Weissman, Venetia Zachariou, Carlos A Zarate, Jon-Kar Zubieta
No abstract text is available yet for this article.
July 15, 2016: Biological Psychiatry
Yuqing Zhang, Na Lu, Christine Peloquin, Maureen Dubreuil, Tuhina Neogi, J Antonio Aviña-Zubieta, Sharan K Rai, Hyon K Choi
OBJECTIVE: Mortality trends of rheumatoid arthritis (RA) are largely unknown over the past decade when new drugs and management strategies have been adopted to effectively treat RA. METHODS: Using The Health Improvement Network, an electronic medical record database representative of the UK general population, we identified patients with incident RA and up to five individuals without RA matched for age, sex and year of diagnosis between 1999 and 2014. The RA cohort was divided in two sub-cohorts based on the year of RA diagnosis: the early cohort (1999-2006) and the late cohort (2007-2014)...
June 23, 2016: Annals of the Rheumatic Diseases
Felipe Calzado, Erica T Prates, Thiago A Gonçalves, Marcelo V Rubio, Mariane P Zubieta, Fabio M Squina, Munir S Skaf, André R L Damásio
Fungal GH12 enzymes are classified as xyloglucanases, when they specifically target xyloglucans, or promiscuous endoglucanases when they exhibit catalytic activity against xyloglucan and β-glucan chains. Several structural and functional studies involving GH12 enzymes tried to explain the main patterns of xyloglucan activity, but what really determines xyloglucanase specificity remains elusive. Here, three fungal GH12 enzymes from Aspergillus clavatus (AclaXegA), A. zonatus (AspzoGH12) and A. terreus (AtEglD) were studied to unveil the molecular basis for substrate specificity...
June 18, 2016: Biotechnology and Bioengineering
Carolyn Neville, Deborah Da Costa, Murray Rochon, Christine A Peschken, Christian A Pineau, Sasha Bernatsky, Stephanie Keeling, Antonio Avina-Zubieta, Elizabeth Lye, Davy Eng, Paul R Fortin
BACKGROUND: Systemic Lupus Erythematosus (SLE) is a serious, complex, and chronic illness. Similar to most other chronic illness states, there is great interest in helping persons with SLE engage in their disease management. OBJECTIVE: The objectives of this study were to (1) develop the Lupus Interactive Navigator (LIN), a web-based self-management program for persons with SLE, and (2) test the LIN for usability and acceptability. METHODS: The LIN development platform was based on the results of preliminary comprehensive needs assessments and adapted from the Oncology Interactive Navigator, a web-based tool developed for persons with cancer...
2016: JMIR Research Protocols
J Antonio Aviña-Zubieta, Alice Mai, Neda Amiri, Natasha Dehghan, Ju Ann Tan, Eric C Sayre, Hyon K Choi
OBJECTIVE: To assess the relative risk of myocardial infarction (MI) and ischemic stroke in cases with newly diagnosed granulomatosis with polyangiitis (GPA) compared to controls from the general population. METHODS: Using a population-based database from the province of British Columbia, Canada, we conducted a matched cohort study of all patients with incident GPA with up to ten age-, sex-, and entry time-matched individuals from the general population. GPA cases required the use of oral glucocorticoids, methotrexate, cyclophosphamide, leflunomide, azathioprine, cyclosporine, mycophenolate mofetil or rituximab within one-month before or six-months after the index date...
May 23, 2016: Arthritis & Rheumatology
Reza Tadayonnejad, Olusola Ajilore, Brian J Mickey, Natania A Crane, David T Hsu, Anand Kumar, Jon-Kar Zubieta, Scott A Langenecker
The pulvinar, the largest thalamus nucleus, has rich anatomical connections with several different cortical and subcortical regions suggesting its important involvement in high-level cognitive and emotional functions. Unfortunately, pulvinar dysfunction in psychiatric disorders particularly major depression disorder has not been thoroughly examined to date. In this study we explored the alterations in the baseline regional and network activities of the pulvinar in MDD by applying spectral analysis of resting-state oscillatory activity, functional connectivity and directed (effective) connectivity on resting-state fMRI data acquired from 20 healthy controls and 19 participants with MDD...
June 30, 2016: Psychiatry Research
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