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https://www.readbyqxmd.com/read/28104280/-robot-assisted-frykman-goldberg-procedure-case-report
#1
Gregorio Zubieta-O'Farrill, Moisés Ramírez-Ramírez, Eduardo Villanueva-Sáenz
BACKGROUND: Rectal prolapse is defined as the protrusion of the rectal wall through the anal canal; with a prevalence of less than 0.5%. The most frequent symptoms include pain, incomplete defecation sensation with blood and mucus, fecal incontinence and/or constipation. The surgical approach can be perineal or abdominal with the tendency for minimal invasion. Robot-assisted procedures are a novel option that offer technique advantages over open or laparoscopic approaches. CASE REPORT: 67 year-old female, who presented with rectal prolapse, posterior to an episode of constipation, that required manual reduction, associated with transanal hemorrhage during defecation and occasional fecal incontinence...
January 16, 2017: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/28040245/the-rising-prevalence-and-incidence-of-gout-in-british-columbia-canada-population-based-trends-from-2000-to-2012
#2
Sharan K Rai, J Antonio Aviña-Zubieta, Natalie McCormick, Mary A De Vera, Kam Shojania, Eric C Sayre, Hyon K Choi
OBJECTIVES: Gout is increasingly recognized as the most common form of inflammatory arthritis worldwide; however, no Canadian data on the disease burden of gout are available. We estimated the prevalence, incidence, prescription patterns, and comorbidity burden of gout in an entire Canadian province [British Columbia (BC)] over the last decade. METHODS: We utilized PopulationData BC, a province-wide database, to estimate temporal trends in the prevalence and incidence of gout from 2000 to 2012, as well as according to age category...
August 17, 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28031164/improvement-in-5-year-mortality-in-incident-rheumatoid-arthritis-compared-with-the-general-population-closing-the-mortality-gap
#3
Diane Lacaille, J Antonio Avina-Zubieta, Eric C Sayre, Michal Abrahamowicz
OBJECTIVE: Excess mortality in rheumatoid arthritis (RA) is expected to have improved over time, due to improved treatment. Our objective was to evaluate secular 5-year mortality trends in RA relative to general population controls in incident RA cohorts diagnosed in 1996-2000 vs 2001-2006. METHODS: We conducted a population-based cohort study, using administrative health data, of all incident RA cases in British Columbia who first met RA criteria between January 1996 and December 2006, with general population controls matched 1:1 on gender, birth and index years...
December 28, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28029234/temporal-trends-of-venous-thromboembolism-risk-before-and-after-diagnosis-of-giant-cell-arteritis
#4
Sebastian Unizony, Na Lu, Gunnar Tomasson, Yuqing Zhang, Peter A Merkel, John H Stone, J Antonio Aviña-Zubieta, Hyon K Choi
OBJECTIVE: Giant cell arteritis (GCA) and the use of glucocorticoids have both been associated with increased risk of venous thromboembolism (VTE). However, the possibility of confounding by indication has not been investigated. We undertook this study to examine the temporal risk of VTE in GCA patients before and after GCA diagnosis, accounting for confounders including glucocorticoid treatment. METHODS: We conducted a matched cohort study using an electronic medical record database representative of the UK population (1990-2013)...
January 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27986128/high-thyroid-stimulating-hormone-levels-increase-proinflammatory-and-cardiovascular-markers-in-patients-with-extreme-obesity
#5
Jaime Héctor Gómez-Zamudio, Victoria Mendoza-Zubieta, Aldo Ferreira-Hermosillo, Marío Antonio Molina-Ayala, Adán Valladares-Sálgado, Fernando Suárez-Sánchez, Jose de Jesús Peralta-Romero, Miguel Cruz
BACKGROUND AND AIMS: Obesity is an important health problem worldwide and many studies have suggested a relationship between obesity and thyroid function, with controversial results. Interestingly, high TSH levels have been involved with the presence of inflammatory state and risk for developing cardiovascular diseases in hypothyroid and obese patients. The aim in this work was to determine the prevalence of hypothyroidism in patients with extreme obesity and to determine whether their TSH levels were related to increased serum levels of inflammatory and cardiovascular markers...
August 2016: Archives of Medical Research
https://www.readbyqxmd.com/read/27895780/curcumin-potentiates-the-effect-of-chemotherapy-against-acute-lymphoblastic-leukemia-cells-via-downregulation-of-nf-%C3%AE%C2%BAb
#6
Helia Judith Pimentel-Gutiérrez, Lucina Bobadilla-Morales, César Cenobio Barba-Barba, Citlalli Ortega-De-La-Torre, Fernando Antonio Sánchez-Zubieta, Jorge Román Corona-Rivera, Betsy Annel González-Quezada, Juan S Armendáriz-Borunda, Rocío Silva-Cruz, Alfredo Corona-Rivera
Acute lymphoblastic leukemia (ALL) accounts for 30% of all pediatric cancers. Currently available treatments exhibit toxicity and certain patients may develop resistance. Thus, less toxic and chemoresistance-reversal agents are required. In the present study, the potential effect of curcumin, a component of Curcuma longa, as a pharmacological co-adjuvant of several chemotherapeutic agents against ALL, including prednisone, 6-mercaptopurine, dexamethasone, cyclophosphamide, l-asparaginase, vincristine, daunorubicin, doxorubicin, methotrexate and cytarabine, was investigated in the REH ALL cell line cultures treated in combination with chemotherapeutic agents and curcumin...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27856269/efficacy-and-safety-of-withholding-antimicrobial-treatment-in-children-with-cancer-fever-and-neutropenia-with-a-demonstrated-viral-respiratory-infection-a-randomized-clinical-trial
#7
M E Santolaya, A M Alvarez, M Acuña, C L Avilés, C Salgado, J Tordecilla, M Varas, M Venegas, M Villarroel, M Zubieta, A Toso, A Bataszew, M J Farfán, V de la Maza, A Vergara, R Valenzuela, J P Torres
OBJECTIVES: To determine efficacy and safety of withholding antimicrobials in children with cancer, fever and neutropenia (FN) with a demonstrated respiratory viral infection. METHODS: Prospective, multicentre, randomized study in children presenting with FN at five hospitals in Santiago, Chile, evaluated at admission for diagnosis of bacterial and viral pathogens including PCR-microarray for 17 respiratory viruses. Children positive for a respiratory virus, negative for a bacterial pathogen and with a favourable evolution after 48 h of antimicrobial therapy were randomized to either maintain or withhold antimicrobials...
November 14, 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27855992/-initial-experience-in-robot-assisted-colorectal-surgery-in-mexico
#8
Eduardo Villanueva-Sáenz, Moisés Marino Ramírez-Ramírez, Gregorio Zubieta-O'Farrill, Luis García-Hernández
BACKGROUND: Colorectal surgery has advanced notably since the introduction of the mechanical suture and the minimally invasive approach. Robotic surgery began in order to satisfy the needs of the patient-doctor relationship, and migrating to the area of colorectal surgery. An initial report is presented on the experience of managing colorectal disease using robot-assisted surgery, as well as an analysis of MATERIAL AND METHODS: A retrospective study was conducted in order to review five patients with colorectal disease intervened with a robot-assisted technique during one year in the initial phase of the learning curve...
November 14, 2016: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/27849615/arabidopsis-thaliana-gh3-5-acyl-acid-amido-synthetase-mediates-metabolic-crosstalk-in-auxin-and-salicylic-acid-homeostasis
#9
Corey S Westfall, Ashley M Sherp, Chloe Zubieta, Sophie Alvarez, Evelyn Schraft, Romain Marcellin, Loren Ramirez, Joseph M Jez
In Arabidopsis thaliana, the acyl acid amido synthetase Gretchen Hagen 3.5 (AtGH3.5) conjugates both indole-3-acetic acid (IAA) and salicylic acid (SA) to modulate auxin and pathogen response pathways. To understand the molecular basis for the activity of AtGH3.5, we determined the X-ray crystal structure of the enzyme in complex with IAA and AMP. Biochemical analysis demonstrates that the substrate preference of AtGH3.5 is wider than originally described and includes the natural auxin phenylacetic acid (PAA) and the potential SA precursor benzoic acid (BA)...
November 29, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27802282/correction-calculation-of-the-average-cost-per-case-of-dengue-fever-in-mexico-using-a-micro-costing-approach
#10
Adriana Zubieta-Zavala, Guillermo Salinas-Escudero, Adrian Ramírez-Chávez, Luis García-Valladares, Malaquias López-Cervantes, Juan Guillermo López Yescas, Luis Durán-Arenas
[This corrects the article DOI: 10.1371/journal.pntd.0004897.].
November 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27768812/preparation-of-an-18-f-labeled-hydrocyanine-dye-as-a-multimodal-probe-for-reactive-oxygen-species
#11
Salma Al-Karmi, Silvia A Albu, Alyssa Vito, Nancy Janzen, Shannon Czorny, Laura Banevicius, Max Nanao, Jon Zubieta, Alfredo Capretta, John F Valliant
Hydrocyanine dyes are sensitive "turn-on" type optical probes that can detect reactive oxygen species (ROS). We have developed a method to prepare an (18) F-labeled hydrocyanine dye as a multi-modal PET and optical "turn-on" probe. A commercially available near infrared (NIR) dye was modified with a fluorinated prosthetic group that did not alter its ROS sensing properties in the presence of superoxide and hydroxyl radicals. The (18) F-labeled analogue was produced using a single-step terminal fluorination procedure...
October 21, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27689471/letter-to-the-editor-re-bicarbonate-values-for-healthy-residents-living-in-cities-above-1500-meters-of-altitude-a-theoretical-model-and-systematic-review-by-ramirez-sandoval-et-al-high-alt-med-biol-2016-17-85-92
#12
Gustavo Zubieta-Calleja, Natalia Zubieta-DeUrioste, Poul-Erik Paulev
No abstract text is available yet for this article.
September 2016: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/27622993/metabolic-and-hormone-influences-on-emotion-processing-during-menopause
#13
Alison Berent-Spillson, Courtney Marsh, Carol Persad, John Randolph, Jon-Kar Zubieta, Yolanda Smith
Disturbances of emotion regulation and depressive symptoms are common during the menopause transition. Reproductive hormone levels are not directly correlated with depressive symptoms, and other factors may influence mood symptoms during menopause. In this study, we sought to determine the role of metabolic function in mood symptoms during menopause, hypothesizing an association with menopause status and long-term glucose load. We studied 54 women across three menopause transition stages (15 premenopause, 11 perimenopause, and 28 postmenopause), examining effects of age, hormones, and metabolism on mood and neural activation during emotional discrimination...
September 5, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27614896/oxytocin-modulates-hemodynamic-responses-to-monetary-incentives-in-humans
#14
Brian J Mickey, Joseph Heffernan, Curtis Heisel, Marta Peciña, David T Hsu, Jon-Kar Zubieta, Tiffany M Love
RATIONALE: Oxytocin is a neuropeptide widely recognized for its role in regulating social and reproductive behavior. Increasing evidence from animal models suggests that oxytocin also modulates reward circuitry in non-social contexts, but evidence in humans is lacking. OBJECTIVES: We examined the effects of oxytocin administration on reward circuit function in 18 healthy men as they performed a monetary incentive task. METHODS: The blood oxygenation level-dependent (BOLD) signal was measured using functional magnetic resonance imaging in the context of a randomized, double-blind, placebo-controlled, crossover trial of intranasal oxytocin...
December 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27599735/merging-of-synchrotron-serial-crystallographic-data-by-a-genetic-algorithm
#15
Ulrich Zander, Michele Cianci, Nicolas Foos, Catarina S Silva, Luca Mazzei, Chloe Zubieta, Alejandro de Maria, Max H Nanao
Recent advances in macromolecular crystallography have made it practical to rapidly collect hundreds of sub-data sets consisting of small oscillations of incomplete data. This approach, generally referred to as serial crystallography, has many uses, including an increased effective dose per data set, the collection of data from crystals without harvesting (in situ data collection) and studies of dynamic events such as catalytic reactions. However, selecting which data sets from this type of experiment should be merged can be challenging and new methods are required...
September 2016: Acta Crystallographica. Section D, Structural Biology
https://www.readbyqxmd.com/read/27565008/trends-in-gout-and-rheumatoid-arthritis-hospitalizations-in-canada-from-2000-2011
#16
Sharan K Rai, J Antonio Aviña-Zubieta, Natalie McCormick, Mary A De Vera, Diane Lacaille, Eric C Sayre, Hyon K Choi
OBJECTIVE: Gout and rheumatoid arthritis (RA) are the two most common forms of inflammatory arthritis worldwide. As hospitalizations for both conditions lead to substantial health resource use, contemporary inpatient trends and associated costs may provide important benchmarks of disease burden. However, relevant data are limited. METHODS: We used PopulationData BC, a population-based administrative dataset from Canada. We examined trends in the annual hospitalization and surgery rate of gout and RA from 2000-2011...
August 26, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27561024/-association-of-inflammatory-cytokines-with-bone-turnover-markers-in-type-1-diabetes
#17
Mario Molina-Ayala, Ruth Carmina Cruz-Soto, Guadalupe Vargas-Ortega, Baldomero González-Virla, Aldo Ferreira-Hermosillo, Julián Mac Gregor-Gooch, Victoria Mendoza-Zubieta
BACKGROUND: Diabetes mellitus (DM) adversely affects the skeleton and the physiological mechanisms implicated have not been explained sufficiently. Thus, the objective was to identify inflammatory cytokines (IL-1, IL-6 and TNF-alpha) in patients with T1DM and their association with markers of bone formation (sPINP) and markers of bone resorption (sCTX). METHODS: We studied 62 patients of 18 years of age or more with T1DM. We determined the values of HbA1c, vitamin D, inflammatory cytokines, as well as those of markers of bone formation and of markers of bone resorption...
2016: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/27561014/-clinical-and-biochemical-characteristics-of-patients-with-morbid-obesity-at-the-time-of-hospital-admission-and-one-year-after-undergoing-bariatric-surgery
#18
Mario Molina-Ayala, Arturo Rodríguez-González, Alejandra Albarrán-Sánchez, Aldo Ferreira-Hermosillo, Claudia Ramírez-Rentería, Enrique Luque-de León, Ilka Bosco-Garate, Fernando Laredo-Sánchez, Roxana Contreras-Herrera, Julián Mac Gregor-Gooch, Carlos Cuevas-García, Victoria Mendoza-Zubieta
BACKGROUND: Three percent of Mexicans suffer from morbid obesity. Comorbidities associated to this condition diminish quality of life, increase mortality and health care costs. Despite bariatric surgery has specific indications and risks, it is the only treatment with effective long-term results. The aim of the study was to evaluate biochemical and clinical patient characteristics, both preoperatively and a year after they underwent bariatric surgery. METHODS: We carried out a quasi-experimental study that evaluates a sample of patients in the Clínica de Obesidad at Hospital de Especialidades (a third level hospital) between March 2011 and October 2015...
2016: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/27525132/persistent-primary-hyperparathyroidism-severe-vitamin-d-deficiency-and-multiple-pathological-fractures
#19
Victoria Mendoza-Zubieta, Mauricio Carvallo-Venegas, Jorge Alberto Vargas-Castilla, Nicolás Ducoing-Sisto, Alfredo Alejandro Páramo-Lovera, Lourdes Josefina Balcázar-Hernández, Julián Malcolm Mac Gregor-Gooch
Persistent primary hyperparathyroidism (PHPT) refers to the sustained hypercalcemia state detected within the first six months following parathyroidectomy. When it coexists with severe vitamin D deficiency, the effects on bone can be devastating. We report the case of a 56-year-old woman who was sent to this center because of persistent hyperparathyroidism. Her disease had over 3 years of evolution with nephrolithiasis and hip fracture. Parathyroidectomy was performed in her local unit; however, she continued with hypercalcemia, bone pain, and pathological fractures...
2016: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/27508003/mapping-n-linked-glycosylation-of-carbohydrate-active-enzymes-in-the-secretome-of-aspergillus-nidulans-grown-on-lignocellulose
#20
Marcelo Ventura Rubio, Mariane Paludetti Zubieta, João Paulo Lourenço Franco Cairo, Felipe Calzado, Adriana Franco Paes Leme, Fabio Marcio Squina, Rolf Alexander Prade, André Ricardo de Lima Damásio
BACKGROUND: The genus Aspergillus includes microorganisms that naturally degrade lignocellulosic biomass, secreting large amounts of carbohydrate-active enzymes (CAZymes) that characterize their saprophyte lifestyle. Aspergillus has the capacity to perform post-translational modifications (PTM), which provides an additional advantage for the use of these organisms as a host for the production of heterologous proteins. In this study, the N-linked glycosylation of CAZymes identified in the secretome of Aspergillus nidulans grown on lignocellulose was mapped...
2016: Biotechnology for Biofuels
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