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https://www.readbyqxmd.com/read/28433485/in-hospital-mortality-in-cirrhotic-patients-at-a-tertiary-care-center
#1
R Zubieta-Rodríguez, J Gómez-Correa, R Rodríguez-Amaya, K A Ariza-Mejia, N A Toloza-Cuta
INTRODUCTION: Cirrhosis of the liver is known for its high risk of mortality associated with episodes of acute decompensation. There is an even greater risk in patients that present with acute-on-chronic liver failure. The identification of patients at higher risk for adverse outcomes can aid in making the clinical decisions that will improve the prognosis for these patients. AIMS: To determine in-hospital mortality and evaluate the epidemiologic and clinical characteristics of patients with cirrhosis of the liver seen at a tertiary referral hospital...
April 19, 2017: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/28419528/an-updated-synthesis-of-11-c-carfentanil-for-positron-emission-tomography-pet-imaging-of-the-%C3%AE-opioid-receptor
#2
Joseph E Blecha, Bradford D Henderson, Brian G Hockley, Henry F VanBrocklin, Jon-Kar Zubieta, Alexandre F DaSilva, Michael R Kilbourn, Robert A Koeppe, Peter J H Scott, Xia Shao
[(11) C]Carfentanil ([(11) C]CFN) is a selective radiotracer for in vivo positron emission tomography (PET) imaging studies of the μ-opioid system that, in our laboratories, is synthesized by methylation of the corresponding carboxylate precursor with [(11) C]MeOTf, and purified using a C2 solid-phase extraction cartridge. Changes in the commercial availability of common C2 cartridges have necessitated future-proofing the synthesis of [(11) C]CFN to maintain reliable delivery of the radiotracer for clinical imaging studies...
April 17, 2017: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/28418376/a-circrna-from-sepallata3-regulates-splicing-of-its-cognate-mrna-through-r-loop-formation
#3
Vanessa M Conn, Véronique Hugouvieux, Aditya Nayak, Stephanie A Conos, Giovanna Capovilla, Gökhan Cildir, Agnès Jourdain, Vinay Tergaonkar, Markus Schmid, Chloe Zubieta, Simon J Conn
Circular RNAs (circRNAs) are a diverse and abundant class of hyper-stable, non-canonical RNAs that arise through a form of alternative splicing (AS) called back-splicing. These single-stranded, covalently-closed circRNA molecules have been identified in all eukaryotic kingdoms of life(1), yet their functions have remained elusive. Here, we report that circRNAs can be used as bona fide biomarkers of functional, exon-skipped AS variants in Arabidopsis, including in the homeotic MADS-box transcription factor family...
April 18, 2017: Nature Plants
https://www.readbyqxmd.com/read/28412878/-top-down-mu-opioid-system-function-in-humans-mu-opioid-receptors-in-ventrolateral-prefrontal-cortex-mediate-the-relationship-between-hedonic-tone-and-executive-function-in-major-depressive-disorder
#4
Sharee N Light, Linas A Bieliauskas, Jon-Kar Zubieta
Cognitive dysfunction and anhedonia, the reduced ability to experience pleasure, are commonly comorbid symptoms that are persistent following successful resolution of negative affect in major depressive disorder (MDD). Little is known about whether they share common etiology. In the present study, the relationship between ventrolateral prefrontal cortex (VLPFC) activity, cognitive dysfunction (i.e., executive dysfunction), and positive emotionality was investigated in conjunction with mu-opioid neurotransmission in a sample of 39 MDD patients...
April 17, 2017: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28362294/a-potential-cu-v-organophosphonate-platform-for-tailored-void-spaces-via-terpyridine-mold-casting
#5
Aysun Bulut, Michael Wörle, Yunus Zorlu, Erdogan Kirpi, Huseyin Kurt, Jon Zubieta, Simon Grabowsky, Jens Beckmann, Gündoğ Yücesan
The reaction of appropriate copper and vanadium salts with tetratopic methane tetra-p-phenylphosphonic acid (MTPPA) in the presence of 2,2':6':2''-terpyridine (terpy) yielded the three-dimensional bimetallic copper vanadium phosphonate framework [{Cu(terpy)}4Cu(VO2)4(MTPPA-H)2]·4H2O (1). Terpy has no net contribution to the three-dimensional structure providing a potential platform for void space formation via mold-casting. The structure was characterized by single-crystal X-ray diffraction and thermogravimetric analysis (TGA)...
April 1, 2017: Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials
https://www.readbyqxmd.com/read/28356463/dopamine-d2-d3-imbalance-during-migraine-attack-and-allodynia-in-vivo
#6
Alexandre F DaSilva, Thiago D Nascimento, Hassan Jassar, Joseph Heffernan, Rebecca L Toback, Sarah Lucas, Marcos F DosSantos, Emily L Bellile, Philip S Boonstra, Jeremy M G Taylor, Kenneth L Casey, Robert A Koeppe, Yolanda R Smith, Jon-Kar Zubieta
OBJECTIVE: To evaluate in vivo the dynamics of endogenous dopamine (DA) neurotransmission during migraine ictus with allodynia. METHODS: We examined 8 episodic migraineurs and 8 healthy controls (HC) using PET with [(11)C]raclopride. The uptake measure of [(11)C]raclopride, nondisplaceable binding potential (BPND), would increase when there was a reduction in endogenous DA release. The opposite is true for a decrease in [(11)C]raclopride BPND. Patients were scanned twice: one PET session was during a spontaneous migraine ictus at rest, followed by a sustained thermal pain threshold (STPT) challenge on the trigeminal region, eliciting an allodynia experience; another was during interictal phase...
March 29, 2017: Neurology
https://www.readbyqxmd.com/read/28344063/asthma-is-associated-with-subsequent-development-of-inflammatory-bowel-disease-a-population-based-case-control-study
#7
M Ellen Kuenzig, Cheryl Barnabe, Cynthia H Seow, Bertus Eksteen, Maria E Negron, Ali Rezaie, Remo Panaccione, Eric I Benchimol, Mohsen Sadatsafavi, J Antonio Aviña-Zubieta, Gilaad G Kaplan
BACKGROUND & AIMS: Asthma and the inflammatory bowel diseases (IBD) each arise through complex interactions between genetic and environmental factors, and share many environmental risk factors. We examined the association between asthma and Crohn's disease or ulcerative colitis. METHODS: We performed a population-based case-control study using health administrative data from the province of Alberta, Canada. The odds of a diagnosis of asthma preceding the diagnosis of either Crohn's disease (n=3087) or ulcerative colitis (n=2377) were compared with the odds of diagnosis of asthma among persons without IBD (n=402,800) using logistic regression...
March 23, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28298559/the-risk-of-deep-venous-thrombosis-and-pulmonary-embolism-in-primary-sj%C3%A3-gren-syndrome-a-general-population-based-study
#8
J Antonio Aviña-Zubieta, Michael Jansz, Eric C Sayre, Hyon K Choi
OBJECTIVE: To estimate the future risk and time trends of venous thromboembolism (VTE) in individuals with newly diagnosed primary Sjögren syndrome (pSS) in the general population. METHODS: Using a population database that includes all residents of British Columbia, Canada, we created a study cohort of all patients with incident SS and up to 10 controls from the general population matched for age, sex, and entry time. We compared incidence rates (IR) of pulmonary embolism (PE), deep vein thrombosis (DVT), and VTE between the 2 groups according to SS disease duration...
March 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28196313/executive-functioning-at-baseline-prospectively-predicts-depression-treatment-response
#9
Erica L Dawson, Angela F Caveney, Kortni K Meyers, Sara L Weisenbach, Bruno Giordani, Erich T Avery, Michael-Paul Schallmo, Armita Bahadori, Linas A Bieliauskas, Matthew Mordhorst, Sheila M Marcus, Kevin Kerber, Jon-Kar Zubieta, Scott A Langenecker
Objective: Existing cognitive and clinical predictors of treatment response to date are not of sufficient strength to meaningfully impact treatment decision making and are not readily employed in clinical settings. This study investigated whether clinical and cognitive markers used in a tertiary care clinic could predict response to usual treatment over a period of 4 to 6 months in a sample of 75 depressed adults. Methods: Patients (N = 384) were sequentially tested in 2 half-day clinics as part of a quality improvement project at an outpatient tertiary care center between August 2003 and September 2007; additional subjects evaluated in the clinic between 2007 and 2009 were also included...
February 9, 2017: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/28192217/the-relation-between-xyr1-overexpression-in-trichoderma-harzianum-and-sugarcane-bagasse-saccharification-performance
#10
Priscila da Silva Delabona, Gisele Nunes Rodrigues, Mariane Paludetti Zubieta, Jonas Ramoni, Carla Aloia Codima, Deise Juliana Lima, Cristiane Sanchez Farinas, José Geraldo da Cruz Pradella, Bernhard Seiboth
This work investigates the influence of the positive regulator XYR1 of Trichoderma harzianum on the production of cellulolytic enzymes, using sugarcane bagasse as carbon source. Constitutive expression of xyr1 was achieved under the control of the strong Trichoderma reesei pki1 promoter. Five clones with xyr1 overexpression achieved higher xyr1 expression and greater enzymatic productivity when cultivated under submerged fermentation, hence validating the genetic construction for T. harzianum. Clone 5 presented a relative expression of xyr1 26-fold higher than the parent strain and exhibited 66, 37, and 36% higher values for filter paper activity, xylanase activity, and β-glucosidase activity, respectively, during cultivation in a stirred-tank bioreactor...
March 20, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28183077/restructuring-hedonic-dysregulation-in-chronic-pain-and-prescription-opioid-misuse-effects-of-mindfulness-oriented-recovery-enhancement-on-responsiveness-to-drug-cues-and-natural-rewards
#11
Eric L Garland, Matthew O Howard, Jon-Kar Zubieta, Brett Froeliger
No abstract text is available yet for this article.
2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/28172519/rna-seq-analysis-of-gene-expression-viral-pathogen-and-b-cell-t-cell-receptor-signatures-in-complex-chronic-disease
#12
Jerome Bouquet, Jennifer L Gardy, Scott Brown, Jacob Pfeil, Ruth R Miller, Muhammad Morshed, Antonio Avina-Zubieta, Kam Shojania, Mark McCabe, Shoshana Parker, Miguel Uyaguari, Scot Federman, Patrick Tang, Ted Steiner, Michael Otterstater, Rob Holt, Richard Moore, Charles Y Chiu, David M Patrick
No abstract text is available yet for this article.
February 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28129475/risk-of-myocardial-infarction-and-stroke-in-newly-diagnosed-systemic-lupus-erythematosus-a-general-population-based-study
#13
J Antonio Aviña-Zubieta, Fergus To, Kateryna Vostretsova, Mary De Vera, Eric C Sayre, John M Esdaile
OBJECTIVE: To estimate the future risk and time trends of newly diagnosed myocardial infarction (MI), ischemic stroke, or both (cardiovascular disease [CVD]) in individuals with systemic lupus erythematosus (SLE). METHODS: Using a population-based database that includes all residents of British Columbia, Canada, we conducted a matched cohort study of all patients with incident SLE and up to ten age-, sex-, and entry-time-matched individuals from the general population...
January 27, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28122876/multidimensional-prediction-of-treatment-response-to-antidepressants-with-cognitive-control-and-functional-mri
#14
Natania A Crane, Lisanne M Jenkins, Runa Bhaumik, Catherine Dion, Jennifer R Gowins, Brian J Mickey, Jon-Kar Zubieta, Scott A Langenecker
Predicting treatment response for major depressive disorder can provide a tremendous benefit for our overstretched health care system by reducing number of treatments and time to remission, thereby decreasing morbidity. The present study used neural and performance predictors during a cognitive control task to predict treatment response (% change in Hamilton Depression Rating Scale pre- to post-treatment). Forty-nine individuals diagnosed with major depressive disorder were enrolled with intent to treat in the open-label study; 36 completed treatment, had useable data, and were included in most data analyses...
February 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28104280/-robot-assisted-frykman-goldberg-procedure-case-report
#15
Gregorio Zubieta-O'Farrill, Moisés Ramírez-Ramírez, Eduardo Villanueva-Sáenz
BACKGROUND: Rectal prolapse is defined as the protrusion of the rectal wall through the anal canal; with a prevalence of less than 0.5%. The most frequent symptoms include pain, incomplete defecation sensation with blood and mucus, fecal incontinence and/or constipation. The surgical approach can be perineal or abdominal with the tendency for minimal invasion. Robot-assisted procedures are a novel option that offer technique advantages over open or laparoscopic approaches. CASE REPORT: 67 year-old female, who presented with rectal prolapse, posterior to an episode of constipation, that required manual reduction, associated with transanal hemorrhage during defecation and occasional fecal incontinence...
January 16, 2017: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/28040245/the-rising-prevalence-and-incidence-of-gout-in-british-columbia-canada-population-based-trends-from-2000-to-2012
#16
Sharan K Rai, J Antonio Aviña-Zubieta, Natalie McCormick, Mary A De Vera, Kam Shojania, Eric C Sayre, Hyon K Choi
OBJECTIVES: Gout is increasingly recognized as the most common form of inflammatory arthritis worldwide; however, no Canadian data on the disease burden of gout are available. We estimated the prevalence, incidence, prescription patterns, and comorbidity burden of gout in an entire Canadian province [British Columbia (BC)] over the last decade. METHODS: We utilized PopulationData BC, a province-wide database, to estimate temporal trends in the prevalence and incidence of gout from 2000 to 2012, as well as according to age category...
February 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28031164/improvement-in-5-year-mortality-in-incident-rheumatoid-arthritis-compared-with-the-general-population-closing-the-mortality-gap
#17
Diane Lacaille, J Antonio Avina-Zubieta, Eric C Sayre, Michal Abrahamowicz
OBJECTIVE: Excess mortality in rheumatoid arthritis (RA) is expected to have improved over time, due to improved treatment. Our objective was to evaluate secular 5-year mortality trends in RA relative to general population controls in incident RA cohorts diagnosed in 1996-2000 vs 2001-2006. METHODS: We conducted a population-based cohort study, using administrative health data, of all incident RA cases in British Columbia who first met RA criteria between January 1996 and December 2006, with general population controls matched 1:1 on gender, birth and index years...
December 28, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28029234/temporal-trends-of-venous-thromboembolism-risk-before-and-after-diagnosis-of-giant-cell-arteritis
#18
Sebastian Unizony, Na Lu, Gunnar Tomasson, Yuqing Zhang, Peter A Merkel, John H Stone, J Antonio Aviña-Zubieta, Hyon K Choi
OBJECTIVE: Giant cell arteritis (GCA) and the use of glucocorticoids have both been associated with increased risk of venous thromboembolism (VTE). However, the possibility of confounding by indication has not been investigated. We undertook this study to examine the temporal risk of VTE in GCA patients before and after GCA diagnosis, accounting for confounders including glucocorticoid treatment. METHODS: We conducted a matched cohort study using an electronic medical record database representative of the UK population (1990-2013)...
January 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27986128/high-thyroid-stimulating-hormone-levels-increase-proinflammatory-and-cardiovascular-markers-in-patients-with-extreme-obesity
#19
Jaime Héctor Gómez-Zamudio, Victoria Mendoza-Zubieta, Aldo Ferreira-Hermosillo, Marío Antonio Molina-Ayala, Adán Valladares-Sálgado, Fernando Suárez-Sánchez, Jose de Jesús Peralta-Romero, Miguel Cruz
BACKGROUND AND AIMS: Obesity is an important health problem worldwide and many studies have suggested a relationship between obesity and thyroid function, with controversial results. Interestingly, high TSH levels have been involved with the presence of inflammatory state and risk for developing cardiovascular diseases in hypothyroid and obese patients. The aim in this work was to determine the prevalence of hypothyroidism in patients with extreme obesity and to determine whether their TSH levels were related to increased serum levels of inflammatory and cardiovascular markers...
August 2016: Archives of Medical Research
https://www.readbyqxmd.com/read/27895780/curcumin-potentiates-the-effect-of-chemotherapy-against-acute-lymphoblastic-leukemia-cells-via-downregulation-of-nf-%C3%AE%C2%BAb
#20
Helia Judith Pimentel-Gutiérrez, Lucina Bobadilla-Morales, César Cenobio Barba-Barba, Citlalli Ortega-De-La-Torre, Fernando Antonio Sánchez-Zubieta, Jorge Román Corona-Rivera, Betsy Annel González-Quezada, Juan S Armendáriz-Borunda, Rocío Silva-Cruz, Alfredo Corona-Rivera
Acute lymphoblastic leukemia (ALL) accounts for 30% of all pediatric cancers. Currently available treatments exhibit toxicity and certain patients may develop resistance. Thus, less toxic and chemoresistance-reversal agents are required. In the present study, the potential effect of curcumin, a component of Curcuma longa, as a pharmacological co-adjuvant of several chemotherapeutic agents against ALL, including prednisone, 6-mercaptopurine, dexamethasone, cyclophosphamide, l-asparaginase, vincristine, daunorubicin, doxorubicin, methotrexate and cytarabine, was investigated in the REH ALL cell line cultures treated in combination with chemotherapeutic agents and curcumin...
November 2016: Oncology Letters
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