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Oral progesterone

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https://www.readbyqxmd.com/read/28199919/relationships-between-oral-muc1-expression-and-salivary-hormones-in-burning-mouth-syndrome
#1
Jeong-Hyun Kang, Yoon-Young Kim, Ji-Youn Chang, Hong-Seop Kho
OBJECTIVES: To investigate possible relationships among oral mucosal epithelial MUC1 expression, salivary female gonadal hormones and stress markers, and clinical characteristics in patients with burning mouth syndrome (BMS). DESIGN: Thirty post-menopausal female patients with BMS (60.0±5.0 years) were included. Clinical and psychological evaluations were performed and the expression level of oral mucosal epithelial MUC1 was analyzed. The levels of cortisol, dehydroepiandrosterone (DHEA), 17β-estradiol, progesterone, chromogranin A, and blood contamination were determined from unstimulated whole saliva (UWS) and stimulated whole saliva (SWS) samples...
February 4, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28182286/maternal-cinnamon-extract-intake-during-lactation-leads-to-sex-specific-endocrine-modifications-in-rat-offspring
#2
Thais Bento-Bernardes, Fernanda P Toste, Carmen C Pazos-Moura, Karen J Oliveira
BACKGROUND: Cinnamon supplementation has been associated with improvement in glucose disposal and reduction in fat mass in type 2 diabetes. Maternal nutrition during lactation impacts the health of the offspring throughout life. We hypothesize that cinnamon intake by lactating rats affects maternal physiology, leading to hormonal and metabolic changes in their offspring. To investigate this hypothesis, dams received aqueous cinnamon extract (400 mg cinnamon/kg body mass/day) or water orally, during lactation...
February 9, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28130434/selective-progesterone-receptor-modulator-sprm-ulipristal-acetate-upa-and-its-effects-on-the-human-endometrium
#3
L H R Whitaker, A A Murray, R Matthews, G Shaw, A R W Williams, P T K Saunders, H O D Critchley
STUDY QUESTION: What is the impact of administration of the selective progesterone receptor modulator (SPRM), ulipristal acetate (UPA) on the endometrium of women with fibroids? SUMMARY ANSWER: UPA administration altered expression of sex-steroid receptors and progesterone-regulated genes and was associated with low levels of glandular and stromal cell proliferation. WHAT IS KNOWN ALREADY: Administration of all SPRM class members results in PAEC (progesterone receptor modulator associated endometrial changes)...
January 26, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28125600/conjugated-linoleic-acid-administration-induces-amnesia-in-male-sprague-dawley-rats-and-exacerbates-recovery-from-functional-deficits-induced-by-a-controlled-cortical-impact-injury
#4
Rastafa I Geddes, Kentaro Hayashi, Quinn Bongers, Marlyse Wehber, Icelle M Anderson, Alex D Jansen, Chase Nier, Emily Fares, Gabrielle Farquhar, Amita Kapoor, Toni E Ziegler, Sivan VadakkadathMeethal, Ian M Bird, Craig S Atwood
Long-chain polyunsaturated fatty acids like conjugated linoleic acids (CLA) are required for normal neural development and cognitive function and have been ascribed various beneficial functions. Recently, oral CLA also has been shown to increase testosterone (T) biosynthesis, which is known to diminish traumatic brain injury (TBI)-induced neuropathology and reduce deficits induced by stroke in adult rats. To test the impact of CLA on cognitive recovery following a TBI, 5-6 month old male Sprague Dawley rats received a focal injury (craniectomy + controlled cortical impact (CCI; n = 17)) or Sham injury (craniectomy alone; n = 12) and were injected with 25 mg/kg body weight of Clarinol® G-80 (80% CLA in safflower oil; n = 16) or saline (n = 13) every 48 h for 4 weeks...
2017: PloS One
https://www.readbyqxmd.com/read/28114999/parity-hormones-and-breast-cancer-subtypes-results-from-a-large-nested-case-control-study-in-a-national-screening-program
#5
Merete Ellingjord-Dale, Linda Vos, Steinar Tretli, Solveig Hofvind, Isabel Dos-Santos-Silva, Giske Ursin
BACKGROUND: Breast cancer comprises several molecular subtypes with different prognoses and possibly different etiology. Reproductive and hormonal factors are associated with breast cancer overall, and with luminal subtypes, but the associations with other subtypes are unclear. We used data from a national screening program to conduct a large nested case-control study. METHODS: We conducted a nested case-control study on participants in the Norwegian Breast Cancer Screening Program in 2006 - 2014...
January 23, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28089524/how-oral-contraceptives-impact-social-emotional-behavior-and-brain-function
#6
REVIEW
Estrella R Montoya, Peter A Bos
Millions of women worldwide use oral contraceptives ('the pill'; OCs), often starting at a pubertal age when their brains are in a crucial developmental stage. Research into the social-emotional effects of OCs is of utmost importance. In this review, we provide an overview of studies that have emerged over the past decade investigating how OCs, and their main ingredients estradiol (E) and progesterone (P), influence social-emotional behaviors and underlying brain functions. Based on this overview, we present a heuristic model that postulates that OCs modulate core social-emotional behaviors and brain systems...
February 2017: Trends in Cognitive Sciences
https://www.readbyqxmd.com/read/28087972/lack-of-effect-of-oral-cabotegravir-on-the-pharmacokinetics-of-a-levonorgestrel-ethinyl-estradiol-containing-oral-contraceptive-in-healthy-adult-females
#7
C Trezza, S L Ford, E Gould, Y Lou, C Huang, J M Ritter, A M Buchanan, W Spreen, P Patel
AIM(S): This study aimed to investigate whether cabotegravir (CAB), an integrase inhibitor in development for treatment and prevention of HIV-1, influences the pharmacokinetics (PK) of a levonorgestrel (LNG) and ethinyl estradiol (EE)-containing oral contraceptive (OC) in healthy women. METHODS: In this open-label, fixed-sequence crossover study, healthy female subjects received LNG 0.15 mg/EE 0.03 mg tablet once daily Days 1-10 alone and with oral CAB 30 mg once daily Days 11-21...
January 14, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28078498/perinatal-exposure-to-bisphenol-a-or-diethylstilbestrol-increases-the-susceptibility-to-develop-mammary-gland-lesions-after-estrogen-replacement-therapy-in-middle-aged-rats
#8
Ayelen L Gomez, Melisa B Delconte, Gabriela A Altamirano, Lucia Vigezzi, Veronica L Bosquiazzo, Luís F Barbisan, Jorge G Ramos, Enrique H Luque, Mónica Muñoz-de-Toro, Laura Kass
The development of the mammary gland is a hormone-regulated event. Several factors can dysregulate its growth and make the gland more susceptible to cellular transformation. Among these factors, perinatal exposure to xenoestrogens and hormone replacement therapy has been associated with increased risk of developing breast cancer. Here, we assessed the effects induced by estrogen replacement therapy (ERT) in ovariectomized (OVX) middle-aged rats and whether perinatal exposure to diethylstilbestrol (DES) or bisphenol A (BPA) modified these effects in the mammary gland...
January 11, 2017: Hormones & Cancer
https://www.readbyqxmd.com/read/28076614/association-between-asthma-and-female-sex-hormones
#9
Raquel Prudente de Carvalho Baldaçara, Ivaldo Silva
CONTEXT AND OBJECTIVE: The relationship between sex hormones and asthma has been evaluated in several studies. The aim of this review article was to investigate the association between asthma and female sex hormones, under different conditions (premenstrual asthma, use of oral contraceptives, menopause, hormone replacement therapy and pregnancy). DESIGN AND SETTING: Narrative review of the medical literature, Universidade Federal do Tocantins (UFT) and Universidade Federal de São Paulo (Unifesp)...
January 5, 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/28064076/drospirenone-reduces-inflammatory-cytokines-vascular-endothelial-growth-factor-vegf-and-nerve-growth-factor-ngf-expression-in-human-endometriotic-stromal-cells
#10
Tomoko Makabe, Kaori Koga, Mariko Miyashita, Arisa Takeuchi, Fusako Sue, Ayumi Taguchi, Yoko Urata, Gentaro Izumi, Masashi Takamura, Miyuki Harada, Tetsuya Hirata, Yasushi Hirota, Osamu Wada-Hiraike, Tomoyuki Fujii, Yutaka Osuga
Drospirenone has been used as a progestin in oral contraceptives with ethinyl estradiol (DRSP/EE) and is expected to regulate endometriosis, however, the direct effects of drospirenone on endometriosis have not been clarified. The aim of this study was to evaluate the anti-inflammatory, anti-angiogenic and anti-neurogenic effects of drospirenone on endometriotic stromal cells (ESC). ESC isolated from endometriotic tissues were obtained from patients during laparoscopic surgery for ovarian endometriosis. ESC were exposed to IL-1β and cultured in the absence or presence of drospirenone...
December 29, 2016: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28050520/oral-health-and-oral-contraceptive-is-it-a-shadow-behind-broad-day-light-a-systematic-review
#11
REVIEW
Irfan Ali, Basavaraj Patthi, Ashish Singla, Ritu Gupta, Kuldeep Dhama, Lav Kumar Niraj, Jishnu Krishna Kumar, Monika Prasad
INTRODUCTION: Oral contraceptives are one of the risk factors for gingival disease. Oral contraceptives can affect the proliferation of cell, growth and differentiation of tissues in the periodontium. Nowadays recent research has suggested that the newer generation oral contraceptives have less influence on gingival diseases. AIM: The purpose of this study was to systematically review the effect of oral contraceptives on periodontium. MATERIALS AND METHODS: A literature review was performed; PubMed, PubMed Central and Cochrane Library, Embase, Google Scholar were searched from 1970 up to December 2015 to identify appropriate studies...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28043741/exposure-to-benzo-a-pyrene-impairs-decidualization-and-decidual-angiogenesis-in-mice-during-early-pregnancy
#12
Xueyan Li, Cha Shen, Xueqing Liu, Junlin He, Yubin Ding, Rufei Gao, Xinyi Mu, Yanqing Geng, Yingxiong Wang, Xuemei Chen
Benzo[a]pyrene (BaP) is a ubiquitous environmental persistent organic pollutant and a well-known endocrine disruptor. BaP exposure could alter the steroid balance in females. Endometrium decidualization and decidual angiogenesis are critical events for embryo implantation and pregnancy maintenance during early pregnancy and are modulated by steroids. However, the effect of BaP on decidualization is not clear. This study aimed to explore the effects of BaP on decidualization and decidual angiogenesis in pregnant mice...
March 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28026087/oral-contraceptive-therapy-reduces-serum-relaxin-2-in-elite-female-athletes
#13
Sayaka Nose-Ogura, Osamu Yoshino, Kaori Yamada-Nomoto, Mariko Nakamura, Miyuki Harada, Michiko Dohi, Toru Okuwaki, Yutaka Osuga, Takashi Kawahara, Shigeru Saito
AIM: Recent investigations have demonstrated that athletes with high relaxin-2 levels have a high risk of anterior cruciate ligament injuries, while athletes taking oral contraceptives (OC) have low relaxin-2 levels. It has not yet been clarified whether taking OC reduces relaxin-2 levels. The purpose of this study was to investigate changes in relaxin-2 levels in athletes taking OC. METHODS: Levels of relaxin-2, estradiol, progesterone, luteinizing hormone and follicle-stimulating hormone were measured in serum samples (n = 183) from 106 elite female athletes...
December 27, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28024920/hepatic-adenomas-in-adolescents-and-young-women-with-endometriosis-treated-with-norethindrone-acetate
#14
P C Brady, S A Missmer, M R Laufer
BACKGROUND: Endometriosis-ectopic implantation of endometrial-like tissue-affects 10% of female adolescents and adults. First-line treatment includes progesterone-only (such as norethindrone acetate, NET-A) or combined estrogen/progestin oral contraceptive pills. Estrogen-containing contraceptives confer increased risk of hepatic adenomas, while the association with NET-A is very rarely reported. CASE: Three adolescents with Stage I-II endometriosis managed with NET-A (up to 15 mg/day for 28-78 months) were diagnosed with hepatic adenomas at ages 17-22 years...
December 23, 2016: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/27972330/comparison-of-mirena-intrauterine-device-with-oral-progesterone-treatment-and-surgical-treatment-in-idiopathic-menorrhagia-patients-results-of-a-cost-minimisation-analysis
#15
N Buyuktuna, F Sumer
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27958631/new-aspects-of-postmenopausal-osteoporosis-treatment-with-micronized-estradiol-and-progesterone
#16
Jarosław von Mach-Szczypiński, Stanisław Stanosz, Jakub Kościuszkiewicz, Krzysztof Safranow
OBJECTIVES: The aim of the study was to assess the effectiveness of postmenopausal osteoporosis treatment with natural sex hormones. MATERIAL AND METHODS: The single-blind study included 210 women, randomly allocated to three different groups, with various methods of treatment: Group I (70 controls) received transcutaneous placebo for the course of one year, Group II (70 females, aged 52.2 ± 3.1 years) used oral hormone supplementary therapy (HST), and Group III (70 females, aged 51...
2016: Ginekologia Polska
https://www.readbyqxmd.com/read/27936434/mineralocorticoid-receptor-haplotype-estradiol-progesterone-and-emotional-information-processing
#17
Danielle A Hamstra, E Ronald de Kloet, Ina Quataert, Myrthe Jansen, Willem Van der Does
BACKGROUND: Carriers of MR-haplotype 1 and 3 (GA/CG; rs5522 and rs2070951) are more sensitive to the influence of oral contraceptives (OC) and menstrual cycle phase on emotional information processing than MR-haplotype 2 (CA) carriers. We investigated whether this effect is associated with estradiol (E2) and/or progesterone (P4) levels. METHOD: Healthy MR-genotyped premenopausal women were tested twice in a counterbalanced design. Naturally cycling (NC) women were tested in the early-follicular and mid-luteal phase and OC-users during OC-intake and in the pill-free week...
February 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27923406/ameliorative-effects-of-rutin-against-metabolic-biochemical-and-hormonal-disturbances-in-polycystic-ovary-syndrome-in-rats
#18
Sarwat Jahan, Faryal Munir, Suhail Razak, Anam Mehboob, Qurat Ul Ain, Hizb Ullah, Tayyaba Afsar, Ghazala Shaheen, Ali Almajwal
BACKGROUND: Polycystic ovary syndrome (PCOS) is the most prevalent endocrinopathy in women of reproductive age. The study was commenced to assess the favorable effects of Rutin against metabolic, biochemical, histological, and androgenic aspects of polycystic ovary syndrome in rats. METHODS: Female Sprague-Dawley rats were administered letrozole (1 mg/kg) per orally (p.o) for a period of 21 days for the induction of PCOS, followed by dose of rutin (100 mg/kg and 150 mg/kg, p...
December 7, 2016: Journal of Ovarian Research
https://www.readbyqxmd.com/read/27919975/long-term-high-quality-survival-with-single-agent-mifepristone-treatment-despite-advanced-cancer
#19
Jerome H Check, Diane Check, Carrie Wilson, Patrice Lofberg
CASE REPORT: We show long-term high-quality survival following single-agent treatment with a progesterone receptor antagonist in two cases of advanced metastatic cancer. Because no biopsy was performed (patient refused) the exact type of lung cancer was not determined but the majority of oncologists who evaluated the patient thought that the rapid onset and syndrome of inappropriate anti-diuretic hormone was more consistent with small-cell lung cancer. The US Food and Drug Association granted a compassionate-use investigational new drug approval for use of single-agent 200 mg mifepristone orally/day to a moribund woman with never-treated metastatic lung cancer and a male with bilateral renal cell carcinoma who had undergone only a unilateral hemi-nephrectomy...
2016: Anticancer Research
https://www.readbyqxmd.com/read/27908454/fulvestrant-500-mg-versus-anastrozole-1-mg-for-hormone-receptor-positive-advanced-breast-cancer-falcon-an-international-randomised-double-blind-phase-3-trial
#20
John F R Robertson, Igor M Bondarenko, Ekaterina Trishkina, Mikhail Dvorkin, Lawrence Panasci, Alexey Manikhas, Yaroslav Shparyk, Servando Cardona-Huerta, Kwok-Leung Cheung, Manuel Jesus Philco-Salas, Manuel Ruiz-Borrego, Zhimin Shao, Shinzaburo Noguchi, Jacqui Rowbottom, Mary Stuart, Lynda M Grinsted, Mehdi Fazal, Matthew J Ellis
BACKGROUND: Aromatase inhibitors are a standard of care for hormone receptor-positive locally advanced or metastatic breast cancer. We investigated whether the selective oestrogen receptor degrader fulvestrant could improve progression-free survival compared with anastrozole in postmenopausal patients who had not received previous endocrine therapy. METHODS: In this phase 3, randomised, double-blind trial, we recruited eligible patients with histologically confirmed oestrogen receptor-positive or progesterone receptor-positive, or both, locally advanced or metastatic breast cancer from 113 academic hospitals and community centres in 20 countries...
17, 2016: Lancet
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