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Oral progesterone

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https://www.readbyqxmd.com/read/29228129/prenatal-exposure-to-di-2-ethylhexyl-phthalate-causes-long-term-transgenerational-effects-on-female-reproduction-in-mice
#1
Emily Brehm, Saniya Rattan, Liying Gao, Jodi A Flaws
Di(2-ethylhexyl) phthalate (DEHP) is a plasticizer in many consumer products. Although DEHP is a known endocrine disruptor, little is known about the effects of DEHP exposure on female reproduction. Thus, this study tested the hypothesis that prenatal DEHP exposure affects follicle numbers, estrous cyclicity, and hormone levels in multiple generations of mice. Pregnant CD-1 mice were orally dosed with corn oil (vehicle control) or DEHP (20 and 200 µg/kg/day, and 500 and 750 mg/kg/day) from gestation day 10...
December 7, 2017: Endocrinology
https://www.readbyqxmd.com/read/29217167/potential-protective-effect-of-pistacia-lentiscus-oil-against-chlorpyrifos-induced-hormonal-changes-and-oxidative-damage-in-ovaries-and-thyroid-of-female-rats
#2
Samira Chebab, Fatiha Mekircha, Essaid Leghouchi
The purpose of this study was to evaluate the protective effect of Pistacia lentiscus oil (PLO), known for its antioxidant properties, on chlorpyrifos (CPF)-induced alterations in the thyroid, reproductive hormone levels, and oxidative damage in the ovaries and thyroid of adult Wistar rats. The animals were treated with orally administered PLO (2 mL/kg), CPF (6.75 mg/kg), and a combination of CPF and PLO for 30 days. Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), progesterone (Pg), estradiol (E2), triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) were assessed using chemiluminescence assay...
December 4, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29214023/assessment-and-clinical-management-of-bone-disease-in-adults-with-eating-disorders-a-review
#3
REVIEW
Anne Drabkin, Micol S Rothman, Elizabeth Wassenaar, Margherita Mascolo, Philip S Mehler
Aim: To review current medical literature regarding the causes and clinical management options for low bone mineral density (BMD) in adult patients with eating disorders. Background: Low bone mineral density is a common complication of eating disorders with potentially lifelong debilitating consequences. Definitive, rigorous guidelines for screening, prevention and management are lacking. This article intends to provide a review of the literature to date and current options for prevention and treatment...
2017: Journal of Eating Disorders
https://www.readbyqxmd.com/read/29208690/aortic-hemodynamics-in-postmenopausal-women-following-cessation-of-hormone-therapy
#4
Ronée E Harvey, Maja C Johnson, Sushant M Ranadive, Michael J Joyner, Brian D Lahr, Virginia M Miller, Jill N Barnes
Central (aortic) blood pressure and aortic pulse wave characteristics are measures of cardiovascular health, predictive of cardiovascular mortality. Previous studies have compared aortic hemodynamics in women who do and do not take menopausal hormone therapy, but characteristics of these parameters following cessation of treatment have not been defined. Therefore, the purpose of this study was to define aortic pulse wave characteristics in postmenopausal women with and without a history of menopausal hormone therapy use...
December 2017: Physiological Reports
https://www.readbyqxmd.com/read/29203165/sex-hormone-levels-in-the-brain-of-d-aspartate-treated-rats
#5
Maria Maddalena Di Fiore, Alessandra Santillo, Sara Falvo, Gabriella Chieffi Baccari, Massimo Venditti, Federica Di Giacomo Russo, Monica Lispi, Antimo D'Aniello
d-Aspartate (d-Asp) is an endogenous amino acid present in the central nervous system and endocrine glands of various animal taxa. d-Asp is implicated in neurotransmission, physiology of learning, and memory processes. In gonads, it plays a crucial role in sex hormone synthesis. We have investigated the effects of chronic (30 days d-Asp drinking solution) and acute (i.p. injection of 2μmol/g bw d-Asp) treatments on sex steroid synthesis in rat brain. Furthermore, to verify the direct effect of d-Asp on neurosteroidogenic enzyme activities, brain homogenates were incubated with different substrates (cholesterol, progesterone, or testosterone) with or without the addition of d-Asp...
December 1, 2017: Comptes Rendus Biologies
https://www.readbyqxmd.com/read/29198242/effect-of-oral-progesterone-and-caffeine-at-the-end-of-gestation-on-farrowing-duration-and-piglet-growth-and-survival
#6
W H E J van Wettere, P Toplis, H M Miller
The profitability of pig production is constrained by high incidences of peri-parturient and pre-weaning piglet mortality. Supplementing sows with either progesterone or caffeine during the last week of gestation can reduce stillbirths and improve piglet performance. However, the consequences of combining these two substances has not been investigated. The aim of the current study was to determine the effect of oral supplementation of sows with progesterone (regumate) and caffeine at the end of gestation on the timing and progression of farrowing, as well as piglet survival and growth to weaning...
December 4, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29194370/alternative-oral-agents-in-prophylaxis-and-therapy-of-uterine-fibroids-an-up-to-date-review
#7
REVIEW
Michał Ciebiera, Krzysztof Łukaszuk, Błażej Męczekalski, Magdalena Ciebiera, Cezary Wojtyła, Aneta Słabuszewska-Jóźwiak, Grzegorz Jakiel
Uterine fibroids (UFs) are the most common tumors of the female genital tract. The effect of UFs on the quality of life and the overall cost of treatment are significant issues worldwide. Tumor size and location are the two specific factors which influence the occurrence of symptoms, the need for, and method of, treatment (some tumors require surgery while some can be treated with selected drugs). Primary prevention and treatment of early UF disease are worthy goals that might have a great impact on health care systems...
December 1, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29180906/perceived-acceptability-of-progesterone-to-prevent-preterm-births-and-low-birth-weight-among-hiv-infected-and-hiv-uninfected-zambian-pregnant-women
#8
Jeffrey Man Hay Wong, Neha Kanga, Nupur Dogra, Mary Shilalukey Ngoma, Lena Serghides, Michael Silverman
Introduction: Intramuscular and vaginal progesterone are recommended for prevention of preterm labor (PTL) in women with risk factors. Studies are emerging to indicate that HIV-infected women on combination antiretroviral therapy (cART) are at risk of PTL and low birth weight (LBW), and may benefit from supplemental progesterone. This study aims to determine the perceived acceptability of various modes of progesterone supplementation to prevent PTL and LBW in HIV-infected and HIV-uninfected women...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/29174867/the-synthesis-of-steroids-by-taenia-crassiceps-wfu-cysticerci-and-tapeworms-is-related-to-the-developmental-stages-of-the-parasites
#9
J M Patricio-Gómez, R A Valdez, A Veloz, L Aguilar-Vega, R Zurabian, M C Romano
Taeniids tapeworms are hermaphroditic helminths that gradually develop testis and ovaries in their reproductive units. The larval stage of the tapeworms named cysticercus is a vesicle that contains the scolex and proliferates asexually in the abdominal cavity of mice. Once in the host, they evaginate, attach to the gut and develop into an adult organism, the tapeworm. We have previously reported reported that T. crassiceps ORF and solium cysticerci transform steroid precursors to androgens and estrogens. Taenia crassiceps WFU cysticerci can also synthesize corticosteroids...
November 22, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29172411/contraception-update-oral-contraception
#10
Elizabeth J Brown, Prium Deshmukh, Karen Antell
The oral contraceptive pill (OCP) is the most commonly used form of reversible contraception. The two types of OCPs are combination oral contraceptives (COCs), which contain estrogen and progesterone, and progestin-only pills (POPs). Both have failure rates of approximately 7.2% to 9% with typical use, and are safe for most patients. Because estrogen-containing contraceptives can increase the risk of venous thromboembolism, patients with conditions associated with a risk of cardiovascular events should not use COCs...
November 2017: FP Essentials
https://www.readbyqxmd.com/read/29169987/the-r-enantiomer-of-ketorolac-delays-mammary-tumor-development-in-mouse-mammary-tumor-virus-polyoma-middle-t-antigen-mmtv-pymt-mice
#11
Amanda S Peretti, Dayna Dominguez, Martha M Grimes, Helen J Hathaway, Eric R Prossnitz, Melanie R Rivera, Angela Wandinger-Ness, Donna F Kusewitt, Laurie G Hudson
Epidemiologic studies report improved breast cancer survival in women receiving ketorolac (Toradol®) for post-operative pain relief compared to other analgesics. Ketorolac is a racemic drug. The S-enantiomer inhibits cyclooxygenases; R-ketorolac is a selective inhibitor of the small GTPases Ras-related C3 botulinum toxin substrate 1 (Rac1) and cell division control protein 42 (Cdc42), which are signaling molecules up-regulated during breast cancer progression and metastasis. our goal was to determine whether R-ketorolac altered breast cancer development in the mouse mammary tumor virus-polyoma middle T-antigen (MMTV-PyMT) model...
November 20, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29165663/oral-contraceptives-and-cigarette-smoking-a-review-of-the-literature-and-future-directions
#12
Alicia M Allen, Andrea H Weinberger, Reagan R Wetherill, Carol L Howe, Sherry A McKee
Introduction: Evidence continues to mount indicating that endogenous sex hormones (e.g., progesterone and estradiol) play a significant role in smoking-related outcomes. Although approximately 1 out of 4 premenopausal smokers use oral contraceptives (OCs), which significantly alter progesterone and estradiol levels, relatively little is known about how OCs may influence smoking-related outcomes. Thus, the goal of this review paper is to describe the state of the literature and offer recommendations for future directions...
November 18, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29165555/prenatal-exposure-to-di-2-ethylhexyl-phthalate-dehp-disrupts-ovarian-function-in-a-transgenerational-manner-in-female-mice
#13
Saniya Rattan, Emily Brehm, Liying Gao, Sarah Niermann, Jodi A Flaws
Di(2-ethylhexyl) phthalate (DEHP) is a plasticizer found in polyvinyl chloride products such as vinyl flooring, plastic food containers, medical devices, and children's toys. DEHP is a ubiquitous environmental contaminant and is a known endocrine disrupting chemical. Little is known about the effects of prenatal DEHP exposure on the ovary and whether effects occur in subsequent generations. Thus, we tested the hypothesis that prenatal exposure to DEHP disrupts ovarian functions in the F1, F2, and F3 generations of female mice...
November 20, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29161960/efficacy-and-safety-of-long-term-use-of-dienogest-in-women-with-ovarian-endometrioma
#14
Sa Ra Lee, Kyong Wook Yi, Jae Yen Song, Seok Kyo Seo, Dong-Yun Lee, SiHyun Cho, Sung Hoon Kim
Dienogest (DNG) is a progestin with highly selective progesterone activity and minimal androgenic activity and is helpful in reducing endometriosis-related pain. This study assessed the long-term efficacy and safety and recurrence rate of endometrioma with DNG use beyond 12 months of treatment. A retrospective cohort study was conducted with data collected from 7 university-affiliated hospitals and included a total of 514 women with ovarian endometrioma. All patients received 2 mg of oral DNG daily for at least 48 weeks postoperatively...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/29126803/sex-differences-in-ochratoxin-a-toxicity-in-f344-rats-after-7-and-21-days-of-daily-oral-administration
#15
Laura Pastor, Ariane Vettorazzi, Jose Manuel Enciso, Elena González-Peñas, J A García-Jalón, J I Monreal, Adela López de Cerain
Ochratoxin A (OTA) is a potent renal carcinogen in male rats but not in females. The mechanisms underlying these differences are unknown. The sex-dependent response of F344 rats after a repeated OTA oral administration for 7 (0.50 mg/kg bw) or 21 days (0.21 and 0.50 mg/kg bw) was evaluated. General toxicity, sex and thyroid hormones and histopathology were studied. OTA was quantified (HPLC-FLD) in plasma, kidney and liver and the expression of kidney transporters (RT-qPCR) was studied. After 7 days, kidney histopathology showed more pronounced signs of toxicity in males than in females...
November 7, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29110260/disparities-in-reproductive-outcomes-according-to-the-endometrial-preparation-protocol-in-frozen-embryo-transfer-the-risk-of-early-pregnancy-loss-in-frozen-embryo-transfer-cycles
#16
I Hatoum, L Bellon, N Swierkowski, M Ouazana, S Bouba, K Fathallah, B Paillusson, M Bailly, F Boitrelle, L Alter, M Bergère, J Selva, R Wainer
PURPOSE: The purpose of this study was to determine the effect of stimulated and artificial endometrial preparation protocols on reproductive outcomes in frozen embryo transfer (FET) cycles. METHODS: We performed a retrospective study of 1926 FET cycles over a 3.5-year period in the Fertility Unit at a University Hospital. Stimulated and artificial protocols were used for endometrial preparation. The embryos for FET were obtained from either in vitro fertilization or intracytoplasmic sperm injection cycles...
November 6, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29109881/hypothermia-with-extreme-bradycardia-following-spinal-cord-infarction-of-septic-origin
#17
Philippe Hantson, Thierry Duprez
Among other autonomic dysfunctions complicating acute spinal cord injury, deep hypothermia is rare but may induce serious cardiovascular complications. There are few pharmacological options to influence hypothermia. A 66-year-old woman was transferred to the intensive care unit (ICU) for serious cardiac arrhythmias (atrial fibrillation and asystole) in the context of a deep hypothermia (axillary temperature below 32°C). She had been admitted to the hospital two months before for an acute L4-L5 infectious spondylodiscitis without any initial neurological deficit...
2017: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/29095983/progesterone-suppression-of-lh-pulse-frequency-in-adolescent-girls-with-hyperandrogenism-effects-of-metformin
#18
Jessica A Lundgren, Su Hee Kim, Christine M Burt Solorzano, Christopher R McCartney, John C Marshall
Context: Polycystic ovary syndrome (PCOS) and adolescent hyperandrogenism (HA) are characterized by rapid LH (GnRH) pulse frequency. This partly reflects impaired GnRH pulse generator (hypothalamic) sensitivity to progesterone (P4) negative feedback. We aimed to assess whether metformin may improve P4 sensitivity in adolescent HA, for which it is prescribed widely. Objective: To test the hypothesis that metformin improves hypothalamic P4 sensitivity in adolescent HA...
October 31, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29082726/-differential-diagnosis-and-management-of-abnormal-uterine-bleeding-in-adolescence
#19
Tiziano Motta, Antonio S Laganà, Gaetano Valenti, Valentina L LA Rosa, Marco Noventa, Amerigo Vitagliano, Benito Chiofalo, Agnese M Rapisarda, Diego Rossetti, Salvatore G Vitale
Abnormal uterine bleeding (AUB) is defined as any atypical genital bleeding originating from the uterine cavity, without the characteristics of normal menstrual period. AUB is an important symptom both for adolescents and their parents, and it usually leads to a state of anxiety. Although about 95% of AUB could be considered as a dysfunctional disorder, AUB requires well-defined diagnostic procedures in order to detect a physical cause, ruling out complex or systemic diseases, including oncological ones. Diagnostic procedures require the acquisition of a full and detailed history, and it is also crucial to obtain as much compliance from the patient as possible...
December 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/29062793/ultra-low-doses-of-follicle-stimulating-hormone-and-progesterone-attenuate-the-severity-of-polycystic-ovary-syndrome-features-in-a-hyperandrogenized-mouse-model
#20
Irene Tessaro, Silvia Modina, Valentina Lodde, Giulia Sivelli, Federica Franciosi, Laura Terzaghi, Patrizia Luchini, Cristiano Rumio, Alberto Maria Luciano
BACKGROUND: Polycystic-ovary syndrome (PCOS) is a reproductive illness characterized by hyperandrogenism and anovulation. Using hyperandrogenized mice, it was demonstrated that the oral administration of incremental dose of follicle stimulating hormone (FSH) attenuated some of PCOS characteristics. This work aimed to study the effect of ultra-low doses of combined FSH and progesterone orally administered on PCOS murine model. Moreover, the effect of sequential kinetic activation of administered hormones was tested...
July 2017: Journal of Reproduction & Infertility
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