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https://www.readbyqxmd.com/read/29901308/-endoscopic-enucleation-of-the-prostate-a-short-term-trend-or-a-new-treatment-standard
#1
P V Glybochko, Yu G Alyaev, L M Rapoport, D V Enikeev, Z Okhunov, C Netsch, L G Spivak, M S Taratkin
Endoscopic enucleation of the prostate (EEP) techniques such as HoLEP (holmium laser enucleation of the prostate), ThuLEP (thulium laser enucleation of the prostate) and electroenucleation (mono- or bipolar) are highly effective and safe. They have been endorsed by the latest version of the European Association of Urology guidelines as an alternative to not only open adenomectomy but also transurethral resection of the prostate (EAU Guidelines on Treatment of Non-neurogenic Male LUTS 2018). Therefore, many urologists face the possibility of replacing the treatments of BPH...
May 2018: Urologii︠a︡
https://www.readbyqxmd.com/read/29871762/did-our-current-initial-treatment-practice-change-after-eau-espu-vesicoureteral-reflux-risk-grouping
#2
Eda Tokat, Serhat Gurocak, Iyimser Ure, Cenk Acar, Zafer Sınık, Mustafa Ozgur Tan
BACKGROUND/PURPOSE: The "European Association of Urology (EAU) Guidelines on Vesicoureteral Reflux (VUR) in Children (September 2012)" established risk classification by analyzing and defining risk factors for each patient. In this study we aimed to investigate how our initial treatment procedures were affected by EAU/ESPU guideline vesicoureteral reflux risk grouping and to compare the early clinical results of treatments performed before and after the risk classification in our patients with VUR...
June 2, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29861867/exploring-the-roles-of-urinary-hai-1-epcam-egfr-in-bladder-cancer-prognosis-risk-stratification
#3
Kym I E Snell, Douglas G Ward, Naheema S Gordon, James C Goldsmith, Andrew J Sutton, Prashant Patel, Nicholas D James, Maurice P Zeegers, K K Cheng, Richard T Bryan
Objectives: To investigate whether elevated urinary HAI-1, EpCAM and EGFR are independent prognostic biomarkers within non-muscle-invasive bladder cancer (NMIBC) patients, and have utility for risk stratification to facilitate treatment decisions. Results: After accounting for EAU risk group in NMIBC patients, the risk of BC-specific death was 2.14 times higher (95% CI: 1.08 to 4.24) if HAI-1 was elevated and 2.04 times higher (95% CI: 1.02 to 4.07) if EpCAM was elevated...
May 18, 2018: Oncotarget
https://www.readbyqxmd.com/read/29847657/comparison-of-aqueous-and-vitreous-lymphocyte-populations-from-two-rat-models-of-experimental-uveitis
#4
Kathryn L Pepple, Leslie Wilson, Russell N Van Gelder
Purpose: To compare lymphocyte populations present within inflamed eyes in two rat models of autoimmune uveitis. Methods: Experimental autoimmune uveitis (EAU) and primed mycobacterial uveitis (PMU) were initiated in Lewis rats. Aqueous and vitreous were collected at peak inflammation (PMU at day 2, EAU at day 14). The number of cells in the aqueous and vitreous was determined and compared for each eye and between the two models. Intraocular CD-19+ B cells, CD3+ T cells, and CD4+ or CD8+ T-cell subpopulations were identified by flow cytometry and compared between EAU and PMU...
May 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29843143/the-role-of-salvage-high-dose-chemotherapy-in-relapsed-male-germ-cell-tumors
#5
Christoph Oing, Anja Lorch
Germ cell tumors (GCT) are a unique tumor entity with excellent cure rates if guideline-endorsed treatment is thoroughly applied. Even patients with widespread metastatic disease can often be cured with cisplatin-based combination chemotherapy as part of a multimodal treatment approach. However, about 30% of patients with metastatic disease at initial presentation, corresponding to about 5-10% of all GCT patients, relapse or progress despite first-line treatment and therefore require salvage chemotherapy. Salvage systemic treatment either consists of conventional-dose cisplatin-based combination chemotherapy or sequential high-dose treatment with carboplatin and etoposide plus subsequent autologous stem cell support...
2018: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29805706/trends-in-treatment-for-prostate-cancer-in-china-preliminary-patterns-of-care-study-in-a-single-institution
#6
Feng Zhao, Jiayan Shen, Zuguo Yuan, Xiaokai Yu, Peng Jiang, Baishu Zhong, Jianjian Xiang, Guoping Ren, Liping Xie, Senxiang Yan
Objectives: A Patterns of Care Study (PCS) was performed in the largest regional medical center in Zhejiang Province, China. The hospital information system (HIS) was used to evaluate patient characteristics and changes in initial treatment patterns for prostate cancer and to determine recent predominant trends in treatment plans for prostate cancer (PCa) in China. Methods: Men who were newly diagnosed with localized or locally advanced PCa for 2010-2011 and 2016-2017 were identified in the HIS database. Patient characteristics and temporal trends in initial management were assessed, and differences between groups were evaluated for significance using Chi-square and Mann-Whitney U tests...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29803559/what-is-new-with-sexual-side-effects-after-transurethral-male-lower-urinary-tract-symptom-surgery
#7
REVIEW
Malte Rieken, Tiago Antunes-Lopes, Bogdan Geavlete, Tom Marcelissen
Transurethral resection of the prostate as well as laser prostatectomy (by either holmium laser enucleation of the prostate or Greenlight laser vaporization) is associated with risks of sexual dysfunction such as antegrade ejaculation and occasionally erectile dysfunction. While ejaculation-sparing variations of these techniques show promising results, larger multicenter studies are needed to confirm promising data. Prostatic urethral lift maintains erectile and ejaculatory function at 5-yr follow-up. The same is true for the 3-yr data on the Rezum system...
May 23, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29772103/how-can-we-expand-active-surveillance-criteria-in-patients-with-low-and-intermediate-risk-prostate-cancer-without-increasing-the-risk-of-misclassification-development-of-a-novel-risk-calculator
#8
Giorgio Gandaglia, Roderick C N van den Bergh, Derya Tilki, Nicola Fossati, Piet Ost, Christian I Surcel, Prasanna Sooriakumaran, Igor Tsaur, Massimo Valerio, Alexander Kretschmer, Emanuele Zaffuto, Laurent Salomon, Francesco Montorsi, Markus Graefen, Henk van der Poel, Alexandre de la Taille, Alberto Briganti, Guillaume Ploussard
OBJECTIVE: To develop a novel tool to increase the number of prostate cancer (PCa) patients eligible for active surveillance (AS) without increasing the risk of unfavourable pathologic features (i.e., misclassification) at radical prostatectomy (RP). MATERIALS AND METHODS: Overall, 16,049 patients with low- or intermediate risk PCa treated with RP were identified. Misclassification was defined as non-organ confined or grade group ≥3 disease at RP. The coefficients of a logistic regression model predicting misclassification were used to develop a risk score...
May 17, 2018: BJU International
https://www.readbyqxmd.com/read/29767327/follow-up-after-curative-treatment-of-localised-renal-cell-carcinoma
#9
REVIEW
Saeed Dabestani, Lorenzo Marconi, Teele Kuusk, Axel Bex
PURPOSE: Patients with localised renal cell carcinoma (RCC) receiving curative surgery, either radical or partial nephrectomy, have been shown in contemporary studies to develop recurrence within 5 years in 20-30% of case. Therefore, post-operative follow-up (FU) imaging plays a crucial role in detecting recurrent or metastatic disease. A number of prognostic scores have been developed to predict risk of recurrence. This review summarises the current knowledge on established FU protocols and their limitations...
May 16, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29756589/effect-of-combination-therapy-with-neuroprotective-and-vasoprotective-agents-on-cerebral-ischemia
#10
Jiping Yang, Bei Yang, Baoxin Xiu, Jinchong Qi, Huaijun Liu
Because most tested drugs are active against only one of the damaging processes associated with stroke, other mechanisms may cause cellular death. Thus, a combination of protective agents targeting different pathophysiological mechanisms may obtain better effects than a single agent. The major objective of this study was to investigate the effect of combination therapy with vascular endothelial growth factor (VEGF) and nerve growth factor (NGF) after controlled ischemic brain injury in rabbits. METHODS: Animals were randomly assigned to one of the following groups: sham group, saline-treated control group or NGF+VEGF-treated group...
May 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29713752/-a-mobile-app-for-patients-suffering-from-kidney-stones
#11
B Becker, N Gadzhiev, M Popiolek, A J Gross, C Netsch
BACKGROUND AND OBJECTIVES: Kidney stone disease has become an important worldwide socioeconomic issue. However, metaphylaxis fails due to low compliance rates. Therefore, we developed a mobile app (StoneMD: Kidney Stones) for patients with kidney stones to increase compliance in stone metaphylaxis. MATERIALS AND METHODS: To identify the most appropriate design of the app, we searched through the App Store and the Google Play Store and integrated the clinical recommendations of the European Association of Urology (EAU) and the American Urological Association (AUA)...
May 2018: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/29678656/complement-mediated-activation-of-the-nlrp3-inflammasome-and-its-inhibition-by-aav-mediated-delivery-of-cd59-in-a-model-of-uveitis
#12
Binit Kumar, Siobhan M Cashman, Rajendra Kumar-Singh
Uveitis is an inflammatory disorder of the eye responsible for approximately 10%-15% of blindness in the US. In this study, we examined the role of the complement membrane attack complex (MAC) and the NLRP3 inflammasome in the pathogenesis of experimental autoimmune uveitis (EAU) in normal and C9-/- mice that are incapable of assembling the MAC. We discovered that the MAC and the NLRP3 inflammasome and associated production of IL-1β are elevated in EAU mice and that MAC may be involved in regulation of Th1 and Th17 cell differentiation...
June 6, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29664124/a-comparison-of-the-treatment-recommendations-for-neurogenic-lower-urinary-tract-dysfunction-in-the-national-institute-for-health-and-care-excellence-european-association-of-urology-and-international-consultations-on-incontinence-guidelines
#13
Ashley Jaggi, Marcus Drake, Emad Siddiqui, Francis Fatoye
AIMS: Healthcare guidelines are an important vehicle in establishing up-to-date evidence based medicine (EBM) in clinical practice. Due to varying development processes, clinical guidelines created by different institutions can often contain contrasting recommendations. This can have implications for optimal and standardized patient care across management settings. METHODS: The similarities and differences of treatment recommendations made in the National Institute for Health and Care Excellence (NICE), The European Association of Urology (EAU), and the International Consultation on Continence (ICI) guidelines for neurogenic lower urinary tract dysfunction (NLUTD) were assessed...
April 17, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29660509/glycosylation-enhanced-biocompatibility-of-the-supramolecular-hydrogel-of-an-anti-inflammatory-drug-for-topical-suppression-of-inflammation
#14
Taotao Xiong, Xianglian Li, Yanfang Zhou, Qianqian Song, Renshu Zhang, Lei Lei, Xingyi Li
Intravitreal/periocular injection of triamcinolone acetonide (TA) suspension is a common uveitis treatment, but it displays a high risk for serious side effects (e.g., high intraocular pressure, retinal toxicity). We report here an intravitreally injectable thermosensitive glycosylated TA (TA-SA-Glu) hydrogel, formed by covalently conjugating glucosamine (Glu) with succinate TA (TA-SA), for treating uveitis. The TA-SA-Glu hydrogelator forms a supramolecular hydrogel spontaneously in aqueous solution with a minimal gelation concentration of 0...
June 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29625456/local-s100a8-levels-correlate-with-recurrence-of-experimental-autoimmune-uveitis-and-promote-pathogenic-t-cell-activity
#15
Juan Yun, Tong Xiao, Lei Zhou, Roger W Beuerman, Juanjuan Li, Yuan Zhao, Amir Hadayer, Xiaomin Zhang, Deming Sun, Henry J Kaplan, Hui Shao
Purpose: To investigate the role of damage-associated molecular patterns (DAMPs) in recurrent experimental autoimmune uveitis (EAU). Methods: Recurrent EAU was induced in Lewis rats by interphotoreceptor retinoid-binding protein (IRBP) R16-peptide specific T cells (tEAU). Aqueous humor and serum samples were kinetically collected and DAMPs examined by quantitative proteomics, Western blot analysis, and ELISA. tEAU rats were treated with S100 inhibitor paquinimod followed by disease evaluation...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29610962/are-clinical-guidelines-designed-according-to-guidelines-cross-sectional-assessment-of-quality-and-transparency-of-clinical-guidelines-in-urology
#16
Roderick C N van den Bergh, Piet Ost, Christian Surcel, Massimo Valerio, Jurgen J Fütterer, Giorgio Gandaglia, Prasanna Sooriakumaran, Derya Tilki, Igor Tsaur, Guillaume Ploussard
PURPOSE: Guidelines and recommendations become increasingly important in clinical urologic practice. This study aims to inform clinicians using guidelines on how to evaluate the quality of the methodology and transparency of these documents. METHODS: The guidelines on management of castration-resistant prostate cancer of the American Urology Association, European Association of Urology, National Comprehensive Cancer Network, National Institute for Health and Care Excellence, European Society of Medical Oncology were reviewed using the AGREE-II tool (Appraisal of Guidelines for Research and Evaluation)...
April 2, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29597836/validation-of-a-novel-cost-effective-easy-to-produce-and-durable-in-vitro-model-for-kidney-puncture-and-percutaneous-nephrolitholapaxy-simulation
#17
Jan-Thorsten Klein, Jens Rassweiler, Marie-Claire Rassweiler-Seyfried
INTRODUCTION: Nephrolithiasis is one of the most common diseases in urology. According to the EAU Guidelines, a percutaneous nephrolitholapaxy (PNL) is recommended when treating a kidney stone >2 cm. Nowadays, PNL is performed even for smaller stones (<1 cm) using miniaturized instruments. The most challenging part of any PNL is the puncture of the planned site. PNL-novice surgeons need to practice this step in a safe environment with an ideal training model. We developed and evaluated a new, easy to produce, in vitro model for the training of the freehand puncture of the kidney...
May 30, 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29572578/crucial-role-of-p2x-7-receptor-for-effector-t-cell-activation-in-experimental-autoimmune-uveitis
#18
Atsunobu Takeda, Hisakata Yamada, Eiichi Hasegawa, Mitsuru Arima, Shoji Notomi, Sayaka Myojin, Takeru Yoshimura, Toshio Hisatomi, Hiroshi Enaida, Ryoji Yanai, Kazuhiro Kimura, Tatsuro Ishibashi, Koh-Hei Sonoda
PURPOSE: To investigate the roles of P2X7 receptors (P2RX7) in the pathogenesis of experimental autoimmune uveoretinitis (EAU). STUDY DESIGN: Experimental. METHODS: Either wild-type (P2rx7 +/+ ) or P2rx7-deficient (P2rx7 -∕- ) mice were immunized with interphotoreceptor retinoid-binding protein (IRBP) peptide 1-20. Severity of EAU was evaluated clinically and histopathologically. The induction of IRBP-specific proliferation and cytokines in draining lymph nodes was assessed by enzyme-linked immunosorbent assays (ELISA)...
May 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29570929/multicentre-international-experience-of-532-nm-laser-photoselective-vaporization-with-greenlight-xps-in-men-with-very-large-prostates
#19
Roger Valdivieso, Pierre-Alain Hueber, Malek Meskawi, Eric Belleville, Khaled Ajib, Franck Bruyere, Alexis E Te, Bilal Chughtai, Dean Elterman, Vincent Misrai, Kevin C Zorn
OBJECTIVES: To describe peri-operative results, functional outcomes and complications of laser photoselective vaporization, using the GreenLight system, of prostate glands ≥200 mL in volume. METHODS: Retrospective analysis of a prospectively maintained multicentre database was performed to select a subgroup of patients with very large prostates (volume ≥200 mL) treated with the GreenLight XPS laser. A subgroup of patients with prostate volumes 100-200 mL was used for comparison...
March 23, 2018: BJU International
https://www.readbyqxmd.com/read/29544735/the-impact-of-implementation-of-the-european-association-of-urology-guidelines-panel-recommendations-on-reporting-and-grading-complications-on-perioperative-outcomes-after-robot-assisted-radical-prostatectomy
#20
Giorgio Gandaglia, Carlo Andrea Bravi, Paolo Dell'Oglio, Elio Mazzone, Nicola Fossati, Simone Scuderi, Daniele Robesti, Francesco Barletta, Luca Grillo, Steven Maclennan, James N'Dow, Francesco Montorsi, Alberto Briganti
The rate of postoperative complications might vary according to the method used to collect perioperative data. We aimed at assessing the impact of the prospective implementation of the European Association of Urology (EAU) guidelines on reporting and grading of complications in prostate cancer patients undergoing robot-assisted radical prostatectomy (RARP). From September 2016, an integrated method for reporting surgical morbidity based on the EAU guidelines was implemented at a single, tertiary center. Perioperative data were prospectively and systematically collected during a patient interview at 30 d after surgery as recommended by the EAU Guidelines Panel Recommendations on Reporting and Grading Complications...
March 12, 2018: European Urology
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