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https://www.readbyqxmd.com/read/29456040/a-very-rare-case-of-renal-cell-carcinoma-metastasis-to-spermatic-cord-and-a-condensed-literature-review
#1
Ioannis Tsouknidas, Nikolaos Tasis, Charalambos Kokkinos, Helen Trihia, Dimitrios Filippou, Panagiotis Skandalakis, Theodoros Troupis
INTRODUCTION: Renal cell carcinoma (RCC) is proved to be the ninth most common malignancy. Two-third of the patients suffering from RCC will present metastases. Secondary metastases of RCC to spermatic cord are very rare. PRESENTATION OF CASE: In this report we present the case of a patient with renal cell carcinoma with metachronous metastasis to the spermatic cord occurring two years after the initial diagnosis of the disease. DISCUSSION: Our patient was treated according to EAU guidelines...
December 26, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29452101/socs3-deficiency-in-myeloid-cells-promotes-retinal-degeneration-and-angiogenesis-through-arginase-1-up-regulation-in-experimental-autoimmune-uveoretinitis
#2
Mei Chen, Jiawu Zhao, Imran Ha Ali, Stephen Marry, Josy Augustine, Mohajeet Bhuckory, Aisling Lynch, Adrien Kissenpfennig, Heping Xu
The suppressor of cytokine signalling protein 3 (SOCS3) critically controls immune cell activation, although its role in macrophage polarization and function remains controversial. Using experimental autoimmune uveoretinitis (EAU) as a model, we show that inflammation-mediated retinal degeneration is exaggerated and retinal angiogenesis is accelerated in mice with SOCS3 deficiency in myeloid cells (LysM Cre/+ SOCS3 fl/fl ). At the acute stage of EAU, the population of infiltrating neutrophils was increased and the population of macrophages decreased in LysM Cre/+ SOCS3 fl/fl mice compared to that in WT mice...
February 13, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29428420/diagnosis-and-treatment-of-male-patients-with-lower-urinary-tract-symptoms-in-spain-the-mercury-study-do-urologists-follow-the-recommendations-of-the-european-guidelines
#3
C Errando-Smet, C Müller-Arteaga, M Hernández, M Roset
OBJECTIVES: To explore the management of lower urinary tract symptoms(LUTS) in men in Spain and assess the compliance with recommendationsestablished in the European Association of Urology (EAU) guidelines. MATERIAL AND METHODS: MERCURY was an epidemiological and cross-sectionalstudy which involved 227 Urology Units across Spain assessing adult malepatients with mixed LUTS and persisting storage symptoms.Sociodemographic, clinical and resource use data for the 6 months priorto study inclusion were collected...
February 7, 2018: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/29424313/mesenchymal-stem-cells-inhibited-dendritic-cells-via-the-regulation-of-stat1-and-stat6-phosphorylation-in-experimental-autoimmune-uveitis
#4
L Dong, X Chen, H Shao, L Bai, X Li, X Zhang
PURPOSE: We have previously reported that MSCs inhibited experimental autoimmune uveitis (EAU) in rodent models induced by either uveitogenic antigens or antigen-specific T cells. In this study, we explored the inhibitory mechanisms of MSCs on dendritic cells (DCs) in EAU. METHODS: We collected the DCs from the lymph nodes of MSC treated or untreated EAU rats, as well as bone marrow derived DCs cultured in vitro with or without MSC treatment. The levels of costimulatory molecules of CD80, CD86, CD40, OX40L and suppressors of cytokine signaling (SOCS1, SOCS2, and SOCS3) on these DCs were analyzed by flow Cytometry...
February 7, 2018: Current Molecular Medicine
https://www.readbyqxmd.com/read/29423823/blunt-testicular-trauma-is-surgical-exploration-necessary
#5
E J Redmond, F T Mac Namara, S K Giri, H D Flood
OBJECTIVES: EAU and AUA guidelines recommend urgent surgical exploration in cases of suspected testicular rupture. However, the management of rupture to other encapsulated organs (e.g. kidney) is primarily non-operative. The aim of this study was to evaluate the conservative management of blunt scrotal trauma. METHODS: Standard practice in our Level II trauma centre is to manage all blunt scrotal injuries conservatively with analgesia, antibiotics and scrotal support...
February 8, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29422356/will-68ga-psma-radioligands-be-the-only-choice-for-nuclear-medicine-in-prostate-cancer-in-the-near-future-a-clinical-update
#6
V Cuccurullo, G D di Stasio, L Evangelista, A Ciarmiello, L Mansi
Prostate Cancer (PCa) represents the most common malignant tumor in men but according to the European Association of Urology (EAU) guidelines, a mass screening for PCa diagnosis should not be performed due to over-diagnosis and over-treatment related problems. An early clinical diagnosis is possible, mainly based on digital rectal examination and Prostatic Specific Agent (PSA) testing. However, the only mandatory test to define the presence of PCa is ultrasound guided-biopsy, obtained on multiple samples, which has also a high prognostic value...
February 5, 2018: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/29398262/eau-guidelines-on-assessment-and-nonsurgical-management-of-urinary-incontinence
#7
Arjun K Nambiar, Ruud Bosch, Francisco Cruz, Gary E Lemack, Nikesh Thiruchelvam, Andrea Tubaro, Dina A Bedretdinova, David Ambühl, Fawzy Farag, Riccardo Lombardo, Marc P Schneider, Fiona C Burkhard
CONTEXT: The European Association of Urology guidelines on urinary incontinence (UI) have been updated in cyclical fashion with successive major chapters being revised each year. The sections on assessment, diagnosis, and nonsurgical treatment have been updated as of mid-2016. OBJECTIVE: We present a condensed version of the full guideline on assessment and nonsurgical management of UI, with the aim of improving accessibility and increasing their dissemination. EVIDENCE ACQUISITION: Our literature search was updated from the previous cut-off of July 2010 up to April 2016...
February 2, 2018: European Urology
https://www.readbyqxmd.com/read/29393997/a-multicentre-integration-of-a-computer-led-follow-up-in-surgical-oncology-is-valid-and-safe
#8
Hesham Salem, Giacomo Caddeo, Jon McFarlane, Kunjan Patel, Lynda Cochrane, Daniele Soria, Mike Henley, Jonathan Lund
BACKGROUND: Prostate cancer (CaP) has a rising number of patients requiring routine follow up. In this study, we aimed to test a computer led follow up service for prostate cancer in two UK hospitals. The testing aimed to validate the computer Expert system in making clinical decisions according to the individual patient's clinical need. The valid model should accurately identify patients with disease recurrence or treatment failure based on their blood test and clinical picture. METHODS: A clinical decision support system (CDSS) was developed from European (EAU) and national (NICE) guidelines along with knowledge acquired from Urologists...
February 2, 2018: BJU International
https://www.readbyqxmd.com/read/29379737/bipolar-transurethral-enucleation-and-resection-of-the-prostate-whether-it-is-ready-to-supersede-turp
#9
Peng Xu, Abai Xu, Binshen Chen, Shaobo Zheng, Yawen Xu, Hulin Li, Haiyan Shen, Chunxiao Liu
Objective: According to the EAU Guidelines, transurethral resection of the prostate (TURP) has so far still been considered as the gold standard for surgical treatment for patients with obstructing clinical benign prostate hyperplasia (BPH). However, its relatively high rate of complications and postoperative recurrence necessitates further modification and innovation on the surgery technique. We reported the patient outcomes with our technique. Methods: We retrospectively analyzed 52 patients with obstructing clinical BPH who underwent bipolar transurethral enucleation and resection of the prostate (B-TUERP) between March 2015 and September 2015...
January 2018: Asian Journal of Urology
https://www.readbyqxmd.com/read/29379727/updates-in-prostate-cancer-detections-and-treatments-messages-from-2017-eau-and-aua
#10
EDITORIAL
Liping Xie, Jiangfeng Li, Xiao Wang
No abstract text is available yet for this article.
January 2018: Asian Journal of Urology
https://www.readbyqxmd.com/read/29372355/worth-a-second-look-outcomes-of-patients-with-initial-finding-of-regular-renal-tissue-in-ct-guided-renal-tumor-biopsies
#11
M Sadat-Khonsari, M Papayannis, P Schriefer, L Kluth, C Meyer, V Schüttfort, M Regier, M Rink, F Chun, M Fisch, A Becker
INTRODUCTION AND OBJECTIVE: Renal tumor biopsy is recommended for histological diagnosis of radiologically indeterminate renal masses, to select patients with small-renal masses for surveillance approaches, before ablative treatments and to confirm metastatic spread of renal cell cancer (RCC), according to the EAU guidelines. We aimed to determine outcomes of patients with suspicious renal masses with initial finding of regular renal tissue in renal tumor biopsies. METHODS: Retrospective database analysis of 101 patients undergoing CT-guided-, percutaneous renal tumor biopsies in local anesthesia...
January 25, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29368429/accuracy-of-standardized-12-core-template-biopsies-versus-non-standardized-biopsies-for-detection-of-epstein-grade-5-prostate-cancer-regarding-the-histology-of-the-prostatectomy-specimen
#12
Christoph Würnschimmel, Pietro Grande, Marco Moschini, Matteo Ferrari, Livio Mordasini, Agostino Mattei
OBJECTIVE: To evaluate the effectiveness of EAU Guideline compliant transrectal ultrasound-guided 12-core prostate biopsies for detection of highly aggressive Epstein Grade 5 (Gleason Score 9-10) prostate cancer. METHODS: Two hundred ninety-nine patients, treated by radical prostatectomy for prostate cancer, have been prospectively recorded in a database and were evaluated for this study. Pre-operatively, all patients received transrectal ultrasound-guided biopsies according to inhomogeneous templates chosen by the referring urologist...
January 25, 2018: Prostate
https://www.readbyqxmd.com/read/29367430/molecular-markers-increase-precision-of-the-european-association-of-urology-non-muscle-invasive-bladder-cancer-progression-risk-groups
#13
Kim E Van Kessel, Kirstin A van der Keur, Lars Dyrskjøt, Ferran Algaba, Naeromy Yc Welvaart, Willemien Beukers, Ulrika Segersten, Bastian Keck, Tobias Maurer, Tatjana Simic, Marcus Horstmann, Marc-Oliver Grimm, Gregers G Hermann, Karin Mogensen, Arndt Hartmann, Niels Harving, Astrid C Petersen, Jørgen B Jensen, Kerstin Junker, Joost L Boormans, Francisco X Real, Nuria Malats, Per-Uno Malmström, Torben F Ørntoft, Ellen C Zwarthoff
PURPOSE: The European Association of Urology (EAU) guidelines for non-muscle invasive bladder cancer (NMIBC) recommend risk stratification based on clinicopathological parameters. Our aim was to investigate the added value of biomarkers to improve risk stratification of NMIBC. EXPERIMENTAL DESIGN: We prospectively included 1239 patients in follow-up for NMIBC in six European countries. Fresh frozen tumor samples were analyzed for GATA2, TBX2, TBX3 and ZIC4 methylation and FGFR3, TERT, PIK3CA and RAS mutation status...
January 24, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29363368/total-glucosides-of-paeony-suppresses-experimental-autoimmune-uveitis-in-association-with-inhibition-of-th1-and-th2-cell-function-in-mice
#14
Xue-Tao Huang, Bin Wang, Wen-Hua Zhang, Man-Qiang Peng, Ding Lin
Total glucosides of paeony (TGP) are active components extracted from the roots of Paeonia lactiflora Pall. In this study, we investigated the role and mechanisms of TGP in experimental autoimmune uveitis (EAU) model of mice. The C57BL/6 mice were randomly divided into three groups: sham group, EAU-control group, and EAU-TGP group. Clinical score of images of the eye fundus were taken on 7, 14, 21, and 28 days after induction of EAU. The concentrations of proinflammatory cytokines in intraocular fluid were measured at 14 days after EAU induction with the use of a multiplex assay system...
January 2018: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/29356668/commodit%C3%A3-s-familiales-et-sant%C3%A3-des-enfants-de-moins-de-cinq-ans-en-ha%C3%A3-ti
#15
Isabelle Roy, Barthélémy Kuate Defo
OBJECTIFS: Évaluer le rôle des commodités familiales dans l'occurrence de la diarrhée chez les enfants de moins de 5 ans en Haïti, selon leur type (eau potable, toilettes et réfrigérateur) et leur nombre.MÉTHODE : Nous avons mis en commun les données de quatre Enquêtes démographiques et de santé réalisées en Haïti entre 1994-1995 et 2012. Nous avons retenu un échantillon de 14 481 enfants de 1-59 mois. Nous avons évalué le rôle des commodités familiales dans l'occurrence de la diarrhée selon le groupe d'âge d'enfants à risque (1-5; 6-11; 12-23; 24-59 mois), au moyen des modèles de régression logistique...
January 22, 2018: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/29354491/opportunities-of-next-generation-sequencing-in-non-muscle-invasive-bladder-cancer-outcome-prediction
#16
REVIEW
Karl H Pang, Francesco Esperto, Aidan P Noon
Bladder cancer (BC) is a common disease in both sexes and majority of cases present as non-muscle invasive BC (NMIBC). The percentage of NMIBC progressing to muscle invasive BC (MIBC) varies between 25% and 75% and currently there are no reliable biomarkers that may predict the outcome of high-risk (HR) NMIBC. Whilst The Cancer Genome Atlas (TCGA) project has identified genetic alteration in MIBC using next-generation sequencing (NGS), genetic data in HR-NMIBC outcome prediction using this new technology are limited...
December 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29339653/adherence-to-the-european-association-of-urology-guidelines-a-national-survey-among-italian-urologists
#17
Giovanni Cacciamani, Walter Artibani, Alberto Briganti, James N'Dow
OBJECTIVE: The study aimed to explore adherence to the European Urological Association (EAU) Guidelines (GLs) grade A recommendation among Italian urologists. MATERIALS AND METHODS: A 13-item multiple-choice questionnaire covering oncological and non-oncological urological diseases was e-mailed to all Italian Urologist Society (Società Italiana di Urologia or SIU) members. We asked members to provide an explanation for their answer choice where needed. The quantitative data were tested using the Pearson's chi-square test...
January 16, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/29336327/current-status-of-urological-training-in-europe
#18
Diego M Carrion, Juan Gómez Rivas, Francesco Esperto, Giulio Patruno, Juan L Vasquez
Modern urological training has changed drastically in the past years, due to the global surgical training trends, advances in technology, subspecialization of the field and, working hour regulations for doctors. The lack of a standardized curriculum across Europe, puts in evidence the great difference in the requirements in every country, from the start of the residency, to obtaining the accreditation. We sought to identify problems related to medical, scientific and surgical activity during urological training, and summarize data obtained from surveys realized during the European Urology Residents Education Programme (EUREP) in 2013, and from countries such as Germany, Italy and Spain...
January 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29326066/novel-everolimus-loaded-nanocarriers-for-topical-treatment-of-murine-experimental-autoimmune-uveoretinitis-eau
#19
Maren Kasper, Doris Gabriel, Michael Möller, Dirk Bauer, Lena Wildschütz, Herve Courthion, Michael R R Böhm, Martin Busch, Karin Loser, Solon Thanos, Robert Gurny, Arnd Heiligenhaus
In the present study, therapeutic effect of topically applied everolimus (EV)-loaded methoxy-poly(ethylene-glycol)-hexyl substituted poly (lactic acid) (mPEGhexPLA) nanocarriers on experimental autoimmune uveitis (EAU) were investigated. EAU was induced in B10.RIII mice via immunization with human interphotoreceptor retinoid-binding protein peptide 161-180 (hIRBPp161-180) in complete Freund's adjuvant. Everolimus-loaded mPEGhexPLA (EV/mPEGhexPLA) nanocarriers were prepared by using a solvent evaporation method...
January 8, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29313299/websites-on-bladder-cancer-an-appropriate-source-of-patient-information
#20
Johannes Salem, Pia Paffenholz, Christian Bolenz, Melanie von Brandenstein, Angelika Cebulla, Axel Haferkamp, Timur Kuru, Cheryl T Lee, David Pfister, Igor Tsaur, Hendrik Borgmann, Axel Heidenreich
A growing number of patients search for health information online. An early investigation of websites about bladder cancer (BCa) revealed mostly incomplete and particularly inaccurate information. We analyzed the quality, readability, and popularity of the most frequented websites on BCa. An Internet search on www.google.com was performed for the term "bladder cancer." After selecting the most frequented websites for patient information, HONcode quality certification, Alexa popularity rank, and readability scores (according to US grade levels) were investigated...
January 8, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
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