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https://www.readbyqxmd.com/read/28734596/developments-in-urologic-oncology-%C3%A2-oncoforum%C3%A2-the-best-of-2016
#1
F Gómez-Veiga, A Alcaraz-Asensio, J Burgos-Revilla, J M Cózar-Olmo
OBJECTIVE: To put forth new findings of urologic oncology with impact on clinical practice presented during 2016 in the main annual meetings. ACQUISITION OF EVIDENCE: This document reviews abstracts on prostate, kidney and bladder cancer presented at the congresses of 2016 (EAU, AUA, ASCO, ESMO and ASTRO) and publications with the highest impact in this period valued with the highest scores by the OncoForum committee. SYNTHESIS OF EVIDENCE: In High-Risk Renal-Cell carcinoma after nephrectomy, disease-free survival was significantly greater for sunitinib than placebo group, with adverse events more frequents...
July 19, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/28721888/long-term-quality-of-life-in-prostate-cancer-patients-treated-with-cesium-131
#2
Scott M Glaser, Katherine S Chen, Ronald M Benoit, Ryan P Smith, Sushil Beriwal
PURPOSE: To evaluate long-term patient-reported quality of life (QOL) scores in men with prostate cancer treated at our institution with (131)Cs prostate brachytherapy. METHODS AND MATERIALS: Patients treated more than 4 years ago with (131)Cs (n=290) were asked to fill out an Expanded Prostate Cancer Index Composite (EPIC) QOL questionnaire and American Urological Association Symptom Score (AUASS) survey, before treatment and at each follow-up appointment. We compared patients' EPIC and AUA scores at baseline with scores at a last follow-up of at least 4 years after treatment using the Wilcoxon signed-rank test...
August 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28712790/prognostic-factors-for-tumor-recurrence-in-patients-with-clinical-stage-i-seminoma-undergoing-surveillance-a-systematic-review
#3
REVIEW
Friedemann Zengerling, Frank Kunath, Katrin Jensen, Christian Ruf, Stefanie Schmidt, Annabel Spek
OBJECTIVE: To systematically evaluate evidence on prognostic factors for tumor recurrence in patients with clinical stage I seminoma undergoing surveillance. METHODS: Systematic literature search conducted of Medline, Web of Science, Cochrane Library, and the conference proceedings of the ASCO, AUA, and EAU meetings (last search: October 2016), according to our prospectively registered protocol (PROSPERO registration number CRD42014009434). Identified records were reviewed according to the Cochrane Method Group of Prognosis Reviews recommendations and the PRISMA reporting guideline...
July 13, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28675645/adult-onset-nocturnal-enuresis-identifying-causes-cofactors-and-impact-on-quality-of-life
#4
Dominic Lee, Benjamin E Dillon, Gary E Lemack
OBJECTIVES: The objectives of the present study were: (i) Evaluate common co-pathologies associated with, and potentially contributing to adult onset Nocturnal enuresis (NE) in a tertiary referral population; and (ii) quantify its impact on QoL with validated questionnaires. METHODS: Following Institutional Review Board approval, patients with adult onset NE were reviewed with history, physical examination, urodynamic studies, questionnaires: Overactive bladder questionnaire short-form (OAB-qSF), Urogenital Distress Inventory (UDI-6), AUA symptom score (AUA-SS) and Patient Global Impression scale (PGIS)...
July 3, 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/28651790/re-multicenter-investigation-of-the-micro-organisms-involved-in-penile-prosthesis-infection-an-analysis-of-the-efficacy-of-the-aua-and-eau-guidelines-for-penile-prosthesis-prophylaxis
#5
https://www.readbyqxmd.com/read/28637364/comparison-of-perioperative-outcomes-between-holmium-laser-enucleation-of-the-prostate-and-robot-assisted-simple-prostatectomy
#6
Mimi W Zhang, Marawan M El Tayeb, Michael S Borofsky, Casey A Dauw, Kristofer R Wagner, Patrick S Lowry, Erin T Bird, Tillman C Hudson, James E Lingeman
OBJECTIVES: To compare perioperative outcomes for patients undergoing holmium laser enucleation of the prostate (HoLEP) and robotic-assisted simple prostatectomy (RSP) for benign prostatic hypertrophy (BPH). METHODS: Patient demographics and perioperative outcomes were compared between 600 patients undergoing HoLEP and 32 patients undergoing RSP at two separate academic institutions between 2008 and 2015. RESULTS: Patients undergoing HoLEP and RSP had comparable ages (71 vs 71, p = 0...
July 19, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28625508/surgical-treatment-of-female-stress-urinary-incontinence-aua-sufu-guideline
#7
Kathleen C Kobashi, Michael E Albo, Roger R Dmochowski, David A Ginsberg, Howard B Goldman, Alexander Gomelsky, Stephen R Kraus, Jaspreet S Sandhu, Tracy Shepler, Jonathan R Treadwell, Sandip Vasavada, Gary E Lemack
PURPOSE: Stress urinary incontinence is a common problem experienced by many women that can have a significant negative impact on the quality of life of those who suffer from the condition and potentially those friends and family members whose lives and activities may also be limited. MATERIALS AND METHODS: A comprehensive search of the literature was performed by ECRI Institute. This search included articles published between January 2005 and December 2015 with an updated abstract search conducted through September 2016...
June 15, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28589400/radical-prostatectomy-for-high-risk-localized-or-node-positive-prostate-cancer-removing-the-primary
#8
REVIEW
Justin T Matulay, G Joel DeCastro
PURPOSE OF REVIEW: We reviewed the literature to determine what role, if any, radical prostatectomy should play in the treatment of high-risk and/or node-positive prostate cancer. RECENT FINDINGS: The AUA, NCCN, and EAU all include radical prostatectomy as a treatment option for high-risk prostate cancer based on evidence that has shown improvements in biochemical-free and disease-specific survival. Lymph node-positive patients may also derive benefit from radical prostatectomy with lymph node dissection, however, only retrospective studies with high risk of selection bias have been published to date...
July 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28584910/factors-that-influence-lower-urinary-tract-symptom-luts-related-quality-of-life-qol-in-a-healthy-population
#9
Woo Suk Choi, Nam Ju Heo, Young Ju Lee, Hwancheol Son
OBJECTIVES: The aim of this study was to evaluate the factors affecting the lower urinary tract symptoms (LUTS) related quality of life (QoL) score. METHODS: This retrospective study analyzed 29,123 men who underwent health check-ups from January 2007 to July 2011 at a single institution. Those patients who completed the American urologic association symptom index (AUA-SI) with QoL, beck depression inventory (BDI) and state-trait anxiety inventory questionnaires were included in the study...
June 5, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28575317/ribosomal-selection-of-mrnas-with-degenerate-initiation-triplets
#10
He Chengguang, Paola Sabatini, Letizia Brandi, Anna M Giuliodori, Cynthia L Pon, Claudio O Gualerzi
To assess the influence of degenerate initiation triplets on mRNA recruitment by ribosomes, five mRNAs identical but for their start codon (AUG, GUG, UUG, AUU and AUA) were offered to a limiting amount of ribosomes, alone or in competition with an identical AUGmRNA bearing a mutation conferring different electrophoretic mobility to the product. Translational efficiency and competitiveness of test mRNAs toward this AUGmRNA were determined quantifying the relative amounts of the electrophoretically separated wt and mutated products synthesized in vitro and found to be influenced to different extents by the nature of their initiation triplet and by parameters such as temperature and nutrient availability in the medium...
May 27, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28573519/patterns-of-care-related-to-post-operative-radiotherapy-for-patients-with-prostate-cancer-among-canadian-radiation-oncologists-and-urologists
#11
Bonnie Bristow, Mohammed Aldehaim, Katija Bonin, Candice Chee Ka Lam, Stephanie J Wan, Xingshan Cao, Ewa Szumacher
The American Society for Radiation Oncology (ASTRO) and American Urological Association (AUA) developed post-prostatectomy radiotherapy (RT) guidelines to aid patient counseling on adjuvant (ART) and salvage radiotherapy (SRT). Our study compared how aware and compliant Canadian radiation oncologists and urologists are to these guidelines. Our online survey was distributed through the Canadian Association of Radiation Oncology (CARO) and Canadian Urology Association (CUA) to radiation oncologists and urologists that treat prostate cancer...
June 2, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28540238/guidelines-of-guidelines-a-review-of-urethral-stricture-evaluation-management-and-follow-up
#12
REVIEW
David B Bayne, Thomas W Gaither, Mohannad A Awad, Gregory P Murphy, E Charles Osterberg, Benjamin N Breyer
BACKGROUND: Our objective is to report a comparative review of recently released guidelines for the evaluation, management, and follow-up of urethral stricture disease. METHODS: This is an analysis of the American Urologic Association (AUA) and Société Internationale d'Urologie (SIU) guidelines on urethral stricture. Strength of recommendations is stratified according to letter grade that corresponds to the level of evidence provided by the literature. RESULTS: Although few, the discrepancies between the recommendations offered by the two guidelines can be best explained by varying interpretations of the literature and available evidence on urethral strictures...
April 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28528859/efficacy-side-effects-and-monitoring-of-oral-cyclosporine-in-interstitial-cystitis-bladder-pain-syndrome
#13
Iryna M Crescenze, Barbara Tucky, Jianbo Li, Courtenay Moore, Daniel A Shoskes
OBJECTIVE: To evaluate the efficacy of oral cyclosporine A (CyA) in the treatment of refractory interstitial cystitis-bladder pain syndrome (IC-BPS) and to assess safety using drug level and renal function monitoring. MATERIALS AND METHODS: Patients with IC-BPS who failed at least 2 prior treatments were enrolled in an open-label study of oral CyA. Medication was started at 3 mg/kg divided twice daily for 3 months. Dose was adjusted based on side effects and the drug level was measured 2 hours after the morning dose (C2)...
May 18, 2017: Urology
https://www.readbyqxmd.com/read/28516158/a-management-algorithm-for-mitomycin-c-induced-cystitis
#14
Amy N Luckenbaugh, Rory M Marks, David C Miller, Alon Z Weizer, John T Stoffel, Jeffrey S Montgomery
Background/Objective: A post-bladder tumor resection dose of MMC can reduce non-invasive papillary (pTa) bladder cancer recurrences by up to 40%; this treatment is recommended in both the AUA and EUA non-muscle-invasive bladder cancer guidelines. A common complication of this treatment is eosinophilic cystitis. Symptoms range from mild urinary frequency and urgency to debilitating pain and dysuria. Currently, there is no established treatment algorithm for MMC-induced cystitis. Methods: Members of the Urologic Surgery Quality Collaborative (USQC), a group composed of over 160 private and academic urologists, met to discuss the management of patients with cystitis following MMC therapy...
April 27, 2017: Bladder Cancer
https://www.readbyqxmd.com/read/28515804/study-habits-of-canadian-urology-residents-implications-for-development-of-a-competence-by-design-curriculum
#15
Thomas A A Skinner, Louisa Ho, Naji J Touma
INTRODUCTION: The purpose of this study was to evaluate the study habits of Canadian urology residents throughout their residency training. METHODS: A survey was administered to all final-year Canadian urology residents over a two-year period. Sixty-seven respondents answered a survey consisting of 54 questions scored on a 10-point Likert score. The survey addressed study habits throughout training, motivations for studying, and preferred resources used. RESULTS: Dedication to studying was directly correlated with proximity to the Royal College of Physicians and Surgeons of Canada (RCPSC) exam...
March 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28506862/a-relevant-midterm-12-months-placebo-effect-on-lower-urinary-tract-symptoms-and-maximum-flow-rate-in-male-lower-urinary-tract-symptom-and-benign-prostatic-hyperplasia-a-meta-analysis
#16
Klaus Eredics, Stephan Madersbacher, Ingrid Schauer
OBJECTIVE: To assess the mid- to long-term placebo effect of the medical and instrumental management of male lower urinary tract symptoms. This is generally a long-term treatment strategy. Therefore, knowledge on the mid- to long-term placebo effect is of considerable interest. The paucity of data on this topic prompted us to investigate this issue in a meta-analysis. METHODS: All randomized controlled trials (RCTs) with the indication of benign prostatic hyperplasia and lower urinary tract symptoms containing a placebo- or sham treatment arm and with a follow-up of 12 months were eligible...
August 2017: Urology
https://www.readbyqxmd.com/read/28483574/aua-policy-statement-on-the-use-of-multiparametric-magnetic-resonance-imaging-in-the-diagnosis-staging-and-management-of-prostate-cancer
#17
Pat F Fulgham, Daniel B Rukstalis, Ismail Baris Turkbey, Jonathan N Rubenstein, Samir Taneja, Peter R Carroll, Peter A Pinto, Marc A Bjurlin, Scott Eggener
PURPOSE: We summarize the available data about the clinical and economic effectiveness of magnetic resonance imaging in the diagnosis and management of prostate cancer, and provide practical recommendations for the its use in the screening, diagnosis, staging and surveillance of prostate cancer. MATERIALS AND METHODS: A panel of clinicians with expertise in the diagnosis and management of prostate cancer evaluated the current published literature on the use and effectiveness of magnetic resonance imaging for this disease...
May 5, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28479239/renal-mass-and-localized-renal-cancer-aua-guideline
#18
Steven Campbell, Robert G Uzzo, Mohamad E Allaf, Eric B Bass, Jeffrey A Cadeddu, Anthony Chang, Peter E Clark, Brian J Davis, Ithaar H Derweesh, Leo Giambarresi, Debra A Gervais, Susie L Hu, Brian R Lane, Bradley C Leibovich, Philip M Pierorazio
PURPOSE: This AUA Guideline focuses on evaluation/counseling and management of adult patients with clinically localized renal masses suspicious for cancer, including solid-enhancing tumors and Bosniak 3/4 complex-cystic lesions. MATERIALS AND METHODS: Systematic review utilized research from the Agency for Healthcare Research and Quality and additional supplementation by the authors and consultant methodologists. Evidence-based statements were based on body of evidence strength Grade A/B/C (Strong/Moderate/Conditional Recommendations, respectively) with additional statements presented as Clinical Principles or Expert Opinions...
May 4, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28472312/alkbh1-is-an-rna-dioxygenase-responsible-for-cytoplasmic-and-mitochondrial-trna-modifications
#19
Layla Kawarada, Takeo Suzuki, Takayuki Ohira, Shoji Hirata, Kenjyo Miyauchi, Tsutomu Suzuki
ALKBH1 is a 2-oxoglutarate- and Fe2+-dependent dioxygenase responsible for multiple cellular functions. Here, we show that ALKBH1 is involved in biogenesis of 5-hydroxymethyl-2΄-O-methylcytidine (hm5Cm) and 5-formyl-2΄-O-methylcytidine (f5Cm) at the first position (position 34) of anticodon in cytoplasmic tRNALeu, as well as f5C at the same position in mitochondrial tRNAMet. Because f5C34 of mitochondrial tRNAMet is essential for translation of AUA, a non-universal codon in mammalian mitochondria, ALKBH1-knockout cells exhibited a strong reduction in mitochondrial translation and reduced respiratory complex activities, indicating that f5C34 formation mediated by ALKBH1 is required for efficient mitochondrial functions...
May 2, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28456635/treatment-of-non-metastatic-muscle-invasive-bladder-cancer-aua-asco-astro-suo-guideline
#20
Sam S Chang, Bernard H Bochner, Roger Chou, Robert Dreicer, Ashish M Kamat, Seth P Lerner, Yair Lotan, Joshua J Meeks, Jeff M Michalski, Todd M Morgan, Diane Z Quale, Jonathan E Rosenberg, Anthony L Zietman, Jeffrey M Holzbeierlein
PURPOSE: This multidisciplinary, evidence-based guideline for clinically non-metastatic muscle-invasive bladder cancer focuses on the evaluation, treatment and surveillance of muscle-invasive bladder cancer guided toward curative intent. MATERIALS AND METHODS: A systematic review utilizing research from the Agency for Healthcare Research and Quality as well as additional supplementation by the authors and consultant methodologists was used to develop the guideline...
April 26, 2017: Journal of Urology
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