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https://www.readbyqxmd.com/read/28086981/does-antiretroviral-treatment-change-hiv-1-codon-usage-patterns-in-its-genes-a-preliminary-bioinformatics-study
#1
Navaneethan Palanisamy, Nathan Osman, Frédéric Ohnona, Hong-Tao Xu, Bluma Brenner, Thibault Mesplède, Mark A Wainberg
BACKGROUND: Codon usage bias has been described for various organisms and is thought to contribute to the regulation of numerous biological processes including viral infections. HIV-1 codon usage has been previously shown to be different from that of other viruses and man. It is evident that the antiretroviral drugs used to restrict HIV-1 replication also select for resistance variants. We wanted to test whether codon frequencies in HIV-1 sequences from treatment-experienced patients differ from those of treatment-naive individuals due to drug pressure affecting codon usage bias...
January 7, 2017: AIDS Research and Therapy
https://www.readbyqxmd.com/read/28058776/guideline-of-guidelines-non-muscle-invasive-bladder-cancer
#2
REVIEW
Solomon L Woldu, Aditya Bagrodia, Yair Lotan
Non-muscle invasive bladder cancer (NMIBC) represents the vast majority of bladder cancer diagnoses, however this definition represents a spectrum of disease with a variable clinical course notable for significant risk of recurrence and potential for progression. Management involves risk-adapted strategies of cystoscopic surveillance and intravesical therapy with a goal of bladder preservation when safe to do so. Multiple organizational guidelines exist to help practitioners manage this complicated disease process, however adherence to management principles amongt practicing urologists is reportedly low...
January 6, 2017: BJU International
https://www.readbyqxmd.com/read/28043843/outcomes-of-holep-in-the-retreatment-setting
#3
Tracy Marien, Mustafa Kadihasanoglu, Teerayut Tangpaitoon, Nadya York, Andrew T Blackburne, Haidar Abdul-Muhsin, Michael S Borofsky, Amy E Krambeck, Mitchell R Humphreys, James E Lingeman, Nicole L Miller
INTRODUCTION: Holmium laser enucleation of the prostate (HoLEP) can also be applied in the retreatment setting when other BPH therapies fail. We sought to compare outcomes of men undergoing HoLEP in the primary versus retreatment setting (pHoLEP versus rHoLEP). MATERIALS AND METHODS: A retrospective review of 2,242 patients undergoing HoLEP at four academic hospitals between 2003 and 2015 was performed. Patient demographic, operative and perioperative outcomes between rHoLEP and pHoLEP were compared...
December 30, 2016: Journal of Urology
https://www.readbyqxmd.com/read/28012747/the-american-urological-association-symptom-index-for-benign-prostatic-hyperplasia
#4
Michael J Barry, Floyd J Fowler, Michael P O'leary, Reginald C Bruskewitz, H Logan Holtgrewe, Winston K Mebust, Abraham T K Cockett
A symptom index for benign prostatic hyperplasia (BPH) was developed and validated by a multidisciplinary measurement committee of the American Urological Association (AUA). Validation studies were conducted involving a total of 210 BPH patients and 108 control subjects. The final AUA symptom index includes 7 questions covering frequency, nocturia, weak urinary stream, hesitancy, intermittence, incomplete emptying and urgency. On revalidation, the index was internally consistent (Cronbach's α = 0.86) and the score generated had excellent test-retest reliability (r = 0...
December 21, 2016: Journal of Urology
https://www.readbyqxmd.com/read/28010967/25-years-of-experience-with-the-aua-symptom-index-increasing-recognition-that-the-bladder-is-an-unreliable-witness
#5
Christopher R Chapple
No abstract text is available yet for this article.
December 20, 2016: Journal of Urology
https://www.readbyqxmd.com/read/28006956/findings-and-impact-of-early-imaging-after-partial-nephrectomy
#6
Ryan W Tubre, William P Parker, Travis Dum, Tim Walmann, Zachary Hamilton, Moben Mirza, David A Duchene
INTRODUCTION: AUA Guidelines for surveillance of renal cell carcinoma after partial nephrectomy recommend imaging within 3-12 months of surgery. Imaging following partial nephrectomy may be difficult to interpret due to the surgical defect, the use of surgical material, and normal post-operative fluid collections. Our primary objective was to evaluate the frequency of indeterminate post-operative imaging results and how those radiographic findings altered patient management. METHODS: Retrospective chart review from 2006 to 2013 of patients who had undergone open, laparoscopic, and robotic partial nephrectomy at our institution was completed...
December 22, 2016: Journal of Endourology
https://www.readbyqxmd.com/read/28003294/acute-uncomplicated-appendicitis-study-rationale-and-protocol-for-a-multicentre-prospective-randomised-controlled-non-inferiority-study-to-evaluate-the-safety-and-effectiveness-of-non-operative-management-in-children-with-acute-uncomplicated-appendicitis
#7
Jane Xu, Yingrui Cyril Liu, Susan Adams, Jonathan Karpelowsky
INTRODUCTION: This article presents an overview of a prospective randomised controlled non-inferiority study designed to evaluate the safety and effectiveness of non-operative management (NOM) with operative management in children with acute uncomplicated appendicitis (AUA). Here, we present the study protocol for this APRES study, a multicentre Australian study. The rationale and details of future analysis, in particular, non-inferiority calculations, cost-effectiveness, feasibility and acceptability of each intervention...
December 21, 2016: BMJ Open
https://www.readbyqxmd.com/read/27987067/prophylactic-antibiotic-treatment-following-laparoscopic-robot-assisted-radical-prostatectomy-for-the-prevention-of-catheter-associated-urinary-tract-infections-did-the-aua-guidelines-make-a-difference
#8
Miki Haifler, Yoram Mor, Zohar Dotan, Jacob Ramon, Dorit E Zilberman
We sought to evaluate the effectiveness of the American Urological Association (AUA) antibiotic prophylaxis guidelines in patients undergoing robot-assisted laparoscopic radical prostatectomy (RALP). Our prospective registry database was reviewed for all RALP cases. The following variables were evaluated: age, associated comorbidities, body mass index (BMI), total operative time, length of stay (LOS), prostate weight, pathological grade and stage. Until 11/2011, RALP patients were treated with antibiotics administered in the operating room and continued until urethral catheter removal...
December 16, 2016: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/27986530/basic-laparoscopic-skills-assessment-study-validation-and-standard-setting-among-canadian-urology-trainees
#9
Jason Y Lee, Sero Andonian, Kenneth T Pace, Ethan Grober
INTRODUCTION: As urology training programs move to a competency-based medical education model, iterative assessments with objective standards will be required. To develop a valid set of technical skills standards, we initiated a national skills assessment study focusing initially on laparoscopic skills. METHODS: Between Feb2014 and Mar2016, the basic laparoscopic skill of Canadian urology trainees and attending urologists was assessed using 4 standardized tasks from the AUA BLUS curriculum; peg transfer, pattern cutting, suturing & knot tying, vascular clip-applying...
December 13, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27928972/a-meta-analysis-of-acute-use-of-alcohol-and-the-risk-of-suicide-attempt
#10
G Borges, C L Bagge, C J Cherpitel, K R Conner, R Orozco, I Rossow
BACKGROUND: No review has used a meta-analytic approach to estimate common odds ratios (ORs) for the effect of acute use of alcohol (AUA) on suicide attempts. We aim to report the results of the first meta-analysis of controlled epidemiological studies on AUA and suicide attempt. METHOD: The English-language literature on Medline, PsycINFO and Google Scholar was searched for original articles and critical review on AUA and suicide attempt (period 1996-2015). Studies had to report an OR estimate for this association...
December 8, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27878056/cua-aua-international-fellows-program-san-diego-2016
#11
Alexandra Bascom
No abstract text is available yet for this article.
August 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/27878055/cua-aua-international-fellows-program-san-diego-2016
#12
Edmund C P Chedgy
No abstract text is available yet for this article.
August 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/27878050/suboptimal-use-of-pelvic-lymph-node-dissection-differences-in-guideline-adherence-between-robot-assisted-and-open-radical-prostatectomy
#13
Jonas Schiffmann, Alessandro Larcher, Maxine Sun, Zhe Tian, Jérémie Berdugo, Ion Leva, Hugues Widmer, Jean-Baptiste Lattouf, Kevin C Zorn, Shahrokh F Shariat, Francesco Montorsi, Markus Graefen, Fred Saad, Pierre I Karakiewicz
INTRODUCTION: Our aim was to assess adherence to National Comprehensive Cancer Network (NCCN) and American Urological Association (AUA) guidelines for pelvic lymph node dissection (PLND) at the time of either robot-assisted (RARP) or open radical prostatectomy (ORP). METHODS: We relied on the Surveillance, Epidemiology, and End Results-Medicare linked database and focused on localized prostate cancer (PCa) patients who were treated with either RARP or ORP between October 2008 and December 2009...
August 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/27872983/robotic-assisted-versus-manual-prostatic-arterial-embolization-for-benign-prostatic-hyperplasia-a-comparative-analysis
#14
Sandeep Bagla, John Smirniotopoulos, Julie C Orlando, Rachel Piechowiak
PURPOSE: Prostatic artery embolization (PAE) is a safe and efficacious procedure for benign prostatic hyperplasia (BPH), though is technically challenging. We present our experience of technical and clinical outcomes of robotic and manual PAE in patients with BPH. MATERIALS AND METHODS: IRB-approved retrospective study of 40 consecutive patients 49-81 years old with moderate or severe grade BPH from May 2014 to July 2015: 20 robotic-assisted PAE (group 1), 20 manual PAE (group 2)...
November 21, 2016: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/27860090/guideline-of-guidelines-priapism
#15
REVIEW
Asif Muneer, David Ralph
No abstract text is available yet for this article.
November 14, 2016: BJU International
https://www.readbyqxmd.com/read/27843182/association-between-components-of-metabolic-syndrome-and-prostatic-enlargement-an-indian-perspective
#16
P R Nandy, Sabyasachi Saha
BACKGROUND: To find association between prostate gland volume to components of the metabolic syndrome. METHODS: Cross-sectional, observational study in a tertiary care hospital of the Armed Forces of India. A total of 115 male patients aged 50-65 years attending the Urology OPD between Jan 2014 and July 2015 with lower urinary tract symptoms (LUTS) were included. Men with known malignant disease including carcinoma prostate, those on medical management for BPH and individuals with previous history of surgery related to urinary bladder/prostate were excluded...
October 2016: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/27833468/best-of-the-2016-aua-annual-meeting-highlights-from-the-2016-american-urological-association-annual-meeting-may-6-10-2016-san-diego-ca
#17
J Curtis Nickel, Michael A Gorin, Partin Alan W, Stacy Loeb, Shapiro Ellen, Michael B Chancellor, Dean G Assimos, Michael K Brawer, Benjamin M Brucker
No abstract text is available yet for this article.
2016: Reviews in Urology
https://www.readbyqxmd.com/read/27832704/re-pre-and-post-operative-predictors-of-infection-related-complications-in-patients-undergoing-percutaneous-nephrolithotomy
#18
Ibrahim Halil Bozkurt, Ismail Basmaci, Tarik Yonguc
No abstract text is available yet for this article.
December 2, 2016: Journal of Endourology
https://www.readbyqxmd.com/read/27785437/are-antibiotics-necessary-during-routine-cystoscopic-stent-removal
#19
Joel E Abbott, Allison Han, Michelle McDonald, Charlie Lakin, Roger L Sur
BACKGROUND: The 2008 American Urological Association (AUA) Best Practice Statement on antimicrobial prophylaxis states that prophylaxis is not warranted for subjects with normal risk profile undergoing cystourethroscopy unless manipulation such as ureteral stent removal is performed. To date no studies have specifically assessed the need for antimicrobial prophylaxis during cystoscopic ureteral stent removal. We sought to determine the risk of infectious complications following cystoscopic stent removal with and without antimicrobial prophylaxis...
October 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/27785044/evaluation-of-the-antipsychotic-medication-review-process-at-four-long-term-facilities-in-alberta
#20
Arden Birney, Paola Charland, Mollie Cole, Mubashir Aslam Arain
PURPOSE: The goal of this evaluation was to understand how four long-term care (LTC) facilities in Alberta have implemented medication reviews for the Appropriate Use of Antipsychotics (AUA) initiative. We aimed to determine how interprofessional (IP) collaboration was incorporated in the antipsychotic medication reviews and how the reviews had been sustained. METHODS: Four LTC facilities in Alberta participated in this evaluation. We conducted semistructured interviews with 18 facility staff and observed one antipsychotic medication review at each facility...
2016: Journal of Multidisciplinary Healthcare
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