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https://www.readbyqxmd.com/read/28625508/surgical-treatment-of-female-stress-urinary-incontinence-aua-sufu-guideline
#1
Kathleen C Kobashi, Michael E Albo, Roger R Dmochowski, David A Ginsberg, Howard B Goldman, Alexander Gomelsky, Stephen R Kraus, Jaspreet S Sandhu, Tracy Shepler, Jonathan R Treadwell, Sandip Vasavada, Gary E Lemack
PURPOSE: Stress urinary incontinence is a common problem experienced by many women that can have a significant negative impact on the quality of life of those who suffer from the condition and potentially those friends and family members whose lives and activities may also be limited. MATERIALS AND METHODS: A comprehensive search of the literature was performed by ECRI Institute. This search included articles published between January 2005 and December 2015 with an updated abstract search conducted through September 2016...
June 15, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28589400/radical-prostatectomy-for-high-risk-localized-or-node-positive-prostate-cancer-removing-the-primary
#2
REVIEW
Justin T Matulay, G Joel DeCastro
PURPOSE OF REVIEW: We reviewed the literature to determine what role, if any, radical prostatectomy should play in the treatment of high-risk and/or node-positive prostate cancer. RECENT FINDINGS: The AUA, NCCN, and EAU all include radical prostatectomy as a treatment option for high-risk prostate cancer based on evidence that has shown improvements in biochemical-free and disease-specific survival. Lymph node-positive patients may also derive benefit from radical prostatectomy with lymph node dissection, however, only retrospective studies with high risk of selection bias have been published to date...
July 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28584910/factors-that-influence-lower-urinary-tract-symptom-luts-related-quality-of-life-qol-in-a-healthy-population
#3
Woo Suk Choi, Nam Ju Heo, Young Ju Lee, Hwancheol Son
OBJECTIVES: The aim of this study was to evaluate the factors affecting the lower urinary tract symptoms (LUTS) related quality of life (QoL) score. METHODS: This retrospective study analyzed 29,123 men who underwent health check-ups from January 2007 to July 2011 at a single institution. Those patients who completed the American urologic association symptom index (AUA-SI) with QoL, beck depression inventory (BDI) and state-trait anxiety inventory questionnaires were included in the study...
June 5, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28575317/ribosomal-selection-of-mrnas-with-degenerate-initiation-triplets
#4
He Chengguang, Paola Sabatini, Letizia Brandi, Anna M Giuliodori, Cynthia L Pon, Claudio O Gualerzi
To assess the influence of degenerate initiation triplets on mRNA recruitment by ribosomes, five mRNAs identical but for their start codon (AUG, GUG, UUG, AUU and AUA) were offered to a limiting amount of ribosomes, alone or in competition with an identical AUGmRNA bearing a mutation conferring different electrophoretic mobility to the product. Translational efficiency and competitiveness of test mRNAs toward this AUGmRNA were determined quantifying the relative amounts of the electrophoretically separated wt and mutated products synthesized in vitro and found to be influenced to different extents by the nature of their initiation triplet and by parameters such as temperature and nutrient availability in the medium...
May 27, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28573519/patterns-of-care-related-to-post-operative-radiotherapy-for-patients-with-prostate-cancer-among-canadian-radiation-oncologists-and-urologists
#5
Bonnie Bristow, Mohammed Aldehaim, Katija Bonin, Candice Chee Ka Lam, Stephanie J Wan, Xingshan Cao, Ewa Szumacher
The American Society for Radiation Oncology (ASTRO) and American Urological Association (AUA) developed post-prostatectomy radiotherapy (RT) guidelines to aid patient counseling on adjuvant (ART) and salvage radiotherapy (SRT). Our study compared how aware and compliant Canadian radiation oncologists and urologists are to these guidelines. Our online survey was distributed through the Canadian Association of Radiation Oncology (CARO) and Canadian Urology Association (CUA) to radiation oncologists and urologists that treat prostate cancer...
June 2, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28540238/guidelines-of-guidelines-a-review-of-urethral-stricture-evaluation-management-and-follow-up
#6
REVIEW
David B Bayne, Thomas W Gaither, Mohannad A Awad, Gregory P Murphy, E Charles Osterberg, Benjamin N Breyer
BACKGROUND: Our objective is to report a comparative review of recently released guidelines for the evaluation, management, and follow-up of urethral stricture disease. METHODS: This is an analysis of the American Urologic Association (AUA) and Société Internationale d'Urologie (SIU) guidelines on urethral stricture. Strength of recommendations is stratified according to letter grade that corresponds to the level of evidence provided by the literature. RESULTS: Although few, the discrepancies between the recommendations offered by the two guidelines can be best explained by varying interpretations of the literature and available evidence on urethral strictures...
April 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28528859/efficacy-side-effects-and-monitoring-of-oral-cyclosporine-in-interstitial-cystitis-bladder-pain-syndrome
#7
Iryna M Crescenze, Barbara Tucky, Jianbo Li, Courtenay Moore, Daniel Shoskes
OBJECTIVE: To evaluate the efficacy of oral Cyclosporine A (CyA) in treatment of refractory interstitial cystitis/bladder pain syndrome (IC/BPS) and assess safety using drug level and renal function monitoring. METHODS: Patients with IC/BPS who failed at least 2 prior treatments were enrolled in an open-label study of oral CyA. Medication was started at 3 mg/kg divided twice daily for 3 months. Dose was adjusted based on side effects and drug level measured 2 hours after the morning dose (C2)...
May 18, 2017: Urology
https://www.readbyqxmd.com/read/28516158/a-management-algorithm-for-mitomycin-c-induced-cystitis
#8
Amy N Luckenbaugh, Rory M Marks, David C Miller, Alon Z Weizer, John T Stoffel, Jeffrey S Montgomery
Background/Objective: A post-bladder tumor resection dose of MMC can reduce non-invasive papillary (pTa) bladder cancer recurrences by up to 40%; this treatment is recommended in both the AUA and EUA non-muscle-invasive bladder cancer guidelines. A common complication of this treatment is eosinophilic cystitis. Symptoms range from mild urinary frequency and urgency to debilitating pain and dysuria. Currently, there is no established treatment algorithm for MMC-induced cystitis. Methods: Members of the Urologic Surgery Quality Collaborative (USQC), a group composed of over 160 private and academic urologists, met to discuss the management of patients with cystitis following MMC therapy...
April 27, 2017: Bladder Cancer
https://www.readbyqxmd.com/read/28515804/study-habits-of-canadian-urology-residents-implications-for-development-of-a-competence-by-design-curriculum
#9
Thomas A A Skinner, Louisa Ho, Naji J Touma
INTRODUCTION: The purpose of this study was to evaluate the study habits of Canadian urology residents throughout their residency training. METHODS: A survey was administered to all final-year Canadian urology residents over a two-year period. Sixty-seven respondents answered a survey consisting of 54 questions scored on a 10-point Likert score. The survey addressed study habits throughout training, motivations for studying, and preferred resources used. RESULTS: Dedication to studying was directly correlated with proximity to the Royal College of Physicians and Surgeons of Canada (RCPSC) exam...
March 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28506862/a-relevant-mid-term-12-months-placebo-effect-on-lower-urinary-tract-symptoms-and-maximum-flow-rate-in-male-luts-bph-a-meta-analysis
#10
Klaus Eredics, Stephan Madersbacher, Ingrid Schauer
OBJECTIVE: To assess the mid- to long-term placebo effect of medical and instrumental management of male lower urinary tract symptoms (LUTS). This is - generally - a long-term treatment strategy. Therefore, knowledge on the mid- to long-term placebo effect is of considerable interest. The paucity of data on this topic prompted us to investigate this issue in a meta-analysis. METHODS: All randomized controlled trials (RCTs) with the indication BPH/LUTS containing a placebo- or sham treatment arm and with a follow-up of 12 months were eligible...
May 12, 2017: Urology
https://www.readbyqxmd.com/read/28483574/aua-standard-operating-procedure-for-mri-of-the-prostate
#11
Pat F Fulgham, Daniel B Rukstalis, Ismail Baris Turkbey, Jonathan N Rubenstein, Samir Taneja, Peter R Carroll, Peter A Pinto, Marc A Bjurlin, Scott Eggener
PURPOSE: The purpose of this review is to summarize the available data about the clinical and economic effectiveness of MRI in the diagnosis and management of prostate cancer and to provide practical recommendations for the use of MRI in the screening, diagnosis, staging and surveillance of prostate cancer. MATERIALS AND METHODS: A panel of clinicians with expertise in the diagnosis and management of prostate cancer evaluated the current published data regarding the use and effectiveness of MRI in the management of prostate cancer...
May 5, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28479239/renal-mass-and-localized-renal-cancer-aua-guideline
#12
Steven Campbell, Robert G Uzzo, Mohamad E Allaf, Eric B Bass, Jeffrey A Cadeddu, Anthony Chang, Peter E Clark, Brian J Davis, Ithaar H Derweesh, Leo Giambarresi, Debra A Gervais, Susie L Hu, Brian R Lane, Bradley C Leibovich, Philip M Pierorazio
PURPOSE: This AUA Guideline focuses on evaluation/counseling and management of adult patients with clinically-localized renal masses suspicious for cancer, including solid-enhancing tumors and Bosniak 3/4 complex-cystic lesions. MATERIALS/METHODS: Systematic review utilized research from the Agency for Healthcare Research and Quality (AHRQ) and additional supplementation by the authors and consultant methodologists. Evidence-based statements were based on body of evidence strength Grade A/B/C (Strong/Moderate/Conditional Recommendations, respectively) with additional statements presented as Clinical Principles or Expert Opinions...
May 4, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28472312/alkbh1-is-an-rna-dioxygenase-responsible-for-cytoplasmic-and-mitochondrial-trna-modifications
#13
Layla Kawarada, Takeo Suzuki, Takayuki Ohira, Shoji Hirata, Kenjyo Miyauchi, Tsutomu Suzuki
ALKBH1 is a 2-oxoglutarate- and Fe2+-dependent dioxygenase responsible for multiple cellular functions. Here, we show that ALKBH1 is involved in biogenesis of 5-hydroxymethyl-2΄-O-methylcytidine (hm5Cm) and 5-formyl-2΄-O-methylcytidine (f5Cm) at the first position (position 34) of anticodon in cytoplasmic tRNALeu, as well as f5C at the same position in mitochondrial tRNAMet. Because f5C34 of mitochondrial tRNAMet is essential for translation of AUA, a non-universal codon in mammalian mitochondria, ALKBH1-knockout cells exhibited a strong reduction in mitochondrial translation and reduced respiratory complex activities, indicating that f5C34 formation mediated by ALKBH1 is required for efficient mitochondrial functions...
May 2, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28456635/treatment-of-non-metastatic-muscle-invasive-bladder-cancer-aua-asco-astro-suo-guideline
#14
Sam S Chang, Bernard H Bochner, Roger Chou, Robert Dreicer, Ashish M Kamat, Seth P Lerner, Yair Lotan, Joshua J Meeks, Jeff M Michalski, Todd M Morgan, Diane Z Quale, Jonathan E Rosenberg, Anthony L Zietman, Jeffrey M Holzbeierlein
PURPOSE: This multi-disciplinary, evidence-based guideline for clinically non-metastatic muscle-invasive bladder cancer focuses on the evaluation, treatment, and surveillance of muscle-invasive bladder cancer guided toward curative intent. MATERIALS AND METHODS: A systematic review utilizing research from the Agency for Healthcare Research and Quality (AHRQ) as well as additional supplementation by the authors and consultant methodologists was used to develop the guideline...
April 26, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28411070/development-and-initial-testing-of-the-flow-instrument-a-novel-assessment-of-lower-urinary-tract-symptoms-in-men
#15
Kelvin A Moses, Daniel Heslop, Derek M Griffith, Arturo Holmes, Lisa Sherden, Consuelo H Wilkins, Kenneth A Wallston
PURPOSE: To develop a method of assessing lower urinary tract symptoms (LUTS) regardless of literacy/numeracy. MATERIALS AND METHODS: We convened focus groups and developed a questionnaire based on four identified domains of urinary function: Frequency, Incontinence (Leakage), Nocturia (Overnight voiding), and Weak stream (FLOW). We pilot tested the novel questionnaire in 64 men and performed quantitative analysis to determine internal consistency. Criterion validity was established via direct comparison to the American Urological Association Symptom Score (AUA-SS) in a larger cohort of 161 men...
April 11, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28410908/national-utilization-of-partial-nephrectomy-pre-and-post-aua-guidelines-is-this-as-good-as-it-gets
#16
Igor Sorokin, Paul J Feustel, Rebecca L O'Malley
BACKGROUND: The purpose of the study was to compare utilization and predictors of partial nephrectomy (PN) in the pre- and post-guideline eras. MATERIALS AND METHODS: American Board of Urology certification/recertification operative logs were reviewed from 2003 to 2014. Nephrectomy cases were extracted using Current Procedural Terminology codes. The cases were then stratified according to pre-guidelines (2003-October 2009) and post-guidelines (November 2009-2014)...
March 23, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28366700/european-association-of-urology-and-american-urological-association-society-of-urologic-oncology-guidelines-on-risk-categories-for-non-muscle-invasive-bladder-cancer-may-lead-to-overtreatment-for-low-grade-ta-bladder-tumors
#17
https://www.readbyqxmd.com/read/28292388/tailored-metabolic-workup-for-urolithiasis-the-debate-continues
#18
M. Hammad Ather, M. Nasir Sulaiman, Imran Siddiqui, Tahmeena Siddiqui
Urolithiasis is one of the commonest afflictions of the urinary tract. Stones are of various chemical compositions, some share some common etiology; but most are specific to the structure and composition of stone. In view of highly recurrent nature of this condition, it is logical to have strategies for prevention. However, due to multiple factors most patients receive no or fragmented information on prevention. The current controversy is to the extent of metabolic workup in adult first time stone former. This requires longitudinal studies to show benefit in prevention strategies...
February 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28265307/antibiotic-prophylaxis-for-prevention-of-urinary-tract-infections-in-prenatal-hydronephrosis-an-updated-systematic-review
#19
REVIEW
Bethany Easterbrook, John-Paul Capolicchio, Luis H Braga
INTRODUCTION: While continuous antibiotic prophylaxis (CAP) is currently recommended to prevent urinary tract infections (UTIs) in infants with prenatal hydronephrosis (HN), this recommendation is not evidence-based. The objective of this study was to systematically determine whether CAP reduces UTIs in the HN population. METHODS: Applicable trials were identified through an electronic search of MEDLINE (1946-2015), EMBASE (1980-2016), CINAHL (1982-2016), and CENTRAL (1993-2016) and through a hand search of American Urological Association (AUA) (2012-2015) and European Society for Pediatric Urology (ESPU) (2012-2015) abstracts, as well as reference lists of included trials...
January 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28263131/factors-and-practice-patterns-that-affect-the-decision-for-vasoepididymostomy
#20
Kevin A Ostrowski, Nicholas N Tadros, A Scott Polackwich, R Dale McClure, Eugene F Fuchs, Jason C Hedges
INTRODUCTION: To determine the factors used to make the decision between vasovasostomy (VV) and vasoepididymostomy (VE) by leaders performing microsurgical vasectomy reversal using a questionnaire. MATERIALS AND METHODS: An online questionnaire was sent to all members of the Society for the Study of Male Reproduction (SSMR), a male reproduction subspecialty society of the AUA, using the SurveyMonkey platform. RESULTS: Sixty-seven surgeons responded to the questionnaire (27% of SSMR members)...
February 2017: Canadian Journal of Urology
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