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https://www.readbyqxmd.com/read/29331546/clinically-localized-prostate-cancer-aua-astro-suo-guideline-part-ii-recommended-approaches-and-details-of-specific-care-options
#1
Martin G Sanda, Jeffrey A Cadeddu, Erin Kirkby, Ronald C Chen, Tony Crispino, Joann Fontanarosa, Stephen J Freedland, Kirsten Greene, Laurence H Klotz, Danil V Makarov, Joel B Nelson, George Rodrigues, Howard M Sandler, Mary Ellen Taplin, Jonathan R Treadwell
PURPOSE: This guideline is structured to provide a clinical framework stratified by cancer severity to facilitate care decisions and guide the specifics of implementing the selected management options. The summary presented herein represents Part II of the two-part series dedicated to Clinically Localized Prostate Cancer: AUA/ASTRO/SUO Guideline discussing risk stratification and care options by cancer severity. Please refer to Part I for discussion of specific care options and outcome expectations and management...
January 10, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29260638/advance-sling-use-decreasing-relative-to-artificial-urinary-sphincters
#2
Chad R Pusateri, Jack M Zuckerman
INTRODUCTION: To evaluate the percent of AdVance male sling usage relative to artificial urinary sphincters (AUS) over a 9 year period since its introduction in order to assess trends across the United States. MATERIALS AND METHODS: As a surrogate for procedures performed, we reviewed device utilization trends of the AdVance sling and AUS broken down by American Urological Association (AUA) section. ANOVA testing between years was used to determine purchasing trends with p values of < 0...
December 2017: Canadian Journal of Urology
https://www.readbyqxmd.com/read/29241263/systematic-review-of-oral-therapy-for-the-treatment-of-symptoms-of-bladder-pain-syndrome-the-brazilian-guidelines
#3
Thaís Guimarães Dos Santos, Isabela Albuquerque Severo de Miranda, Christiana Campani Nygaard, Lucas Schreiner, Rodrigo de Aquino Castro, Jorge Milhen Haddad
Interstitial cystitis (IC), including bladder pain syndrome (BPS), is a chronic and debilitating disease that mainly affects women. It is characterized by pelvic pain associated with urinary urgency, frequency, nocturia and negative urine culture, with normal cytology. In 2009, the Society for Urodynamics and Female Urology (SUFU) defined the term IC/BPS as "an unpleasant sensation (pain, pressure, and discomfort) perceived to be related to the urinary bladder, associated with lower urinary tract symptoms for more than 6 weeks duration, in the absence of infection or other identifiable causes...
December 14, 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29221932/evaluation-of-guidelines-for-surgical-management-of-urolithiasis
#4
Benjamin Pradère, Steeve Doizi, Silvia Proietti, Jan Brachlow, Olivier Traxer
PURPOSE: Many urological societies have provided evidence-based guidelines to help the urologist in making therapeutic choices. However, the recommendations given by these guidelines may be heterogeneous because they have been developed using a variety of methods. The objective of this study was to review key guidelines on the surgical management of urinary stones to provide practical guidance for clinical application. MATERIALS AND METHODS: Guidelines on urolithiasis from all international urological societies were searched through the society websites...
December 5, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29203269/clinically-localized-prostate-cancer-aua-astro-suo-guideline-part-i-risk-stratification-shared-decision-making-and-care-options
#5
Martin G Sanda, Jeffrey A Cadeddu, Erin Kirkby, Ronald C Chen, Tony Crispino, Joann Fontanarosa, Stephen J Freedland, Kirsten Greene, Laurence H Klotz, Danil V Makarov, Joel B Nelson, George Rodrigues, Howard M Sandler, Mary Ellen Taplin, Jonathan R Treadwell
PURPOSE: This guideline is structured to provide a clinical framework stratified by cancer severity to facilitate care decisions and guide the specifics of implementing the selected management options. The summary presented represents Part I of the two-part series dedicated to Clinically Localized Prostate Cancer: AUA/ASTRO/SUO Guideline discussing risk stratification and care options by cancer severity. MATERIALS AND METHODS: The systematic review utilized in the creation of this guideline was completed by the Agency for Healthcare Research and Quality and through additional supplementation by ECRI Institute...
December 14, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29179565/american-urological-association-antibiotic-best-practice-statement-and-ureteroscopy-does-antibiotic-stewardship-help
#6
Daniel J Greene, Bradley C Gill, Bryan Hinck, Yaw A Nyame, Nima Almassi, Venkatesh Krishnamurthi, Mark Noble, Sri Sivalingam, Manoj Monga
PURPOSE: To determine compliance with the American Urological Association (AUA) antimicrobial prophylaxis best practice statement and whether the use of postoperative antibiotics is associated with lower rates of postoperative urinary tract infection (UTI) in patients with nephroureterolithiasis and a negative preoperative urine culture undergoing ureteroscopy. MATERIALS AND METHODS: A retrospective review of all adult patients undergoing ureteroscopy from 2013 to 2014 for stone disease with a negative preoperative urine was conducted...
January 3, 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29107280/castration-resistant-prostate-cancer-an-algorithmic-approach
#7
REVIEW
Kelly Stratton, Michael Cookson
Since 2010, 5 new agents have been approved for advanced prostate cancer treatment. The American Urologic Association (AUA) published guidelines for the management of castration-resistant prostate cancer in 2013. These guidelines identify 6 index patients to consider when selecting the most appropriate treatment. No comparative trials have provided an approach to optimize the sequencing of these drugs. For the urologist, incorporating the guidelines into clinical practice typically requires a multidisciplinary team...
November 2017: Urologic Clinics of North America
https://www.readbyqxmd.com/read/29092074/characterization-of-redundant-trnailes-with-cau-and-uau-anticodons-in-lactobacillus-plantarum
#8
Chie Tomikawa, Sylvie Auxilien, Vincent Guérineau, Yuya Yoshioka, Kiyo Miyoshi, Hiroyuki Hori, Dominique Fourmy, Kazuyuki Takai, Satoko Yoshizawa
In most eubacteria, the minor AUA isoleucine codon is decoded by tRNAIle2, which has a lysidine (L) in the anticodon loop. The lysidine is introduced by tRNAIle-lysidine synthetase (TilS) through post-transcriptional modification of cytidine to yield an LAU anticodon. Some bacteria, Lactobacillus plantarum for example, possess two tRNAIle2(UAU) genes in addition to, two tRNAIle2(CAU) genes and the tilS gene. tRNA expression from all these genes would generate redundancy in a tRNA that decodes a rare AUA codon...
October 30, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/29081016/a-review-of-imaging-modalities-used-in-the-diagnosis-and-management-of-scrotal-trauma
#9
REVIEW
Alexis Wang, Ian Stormont, M Minhaj Siddiqui
Genitourinary tract injuries account for 3 to 10% of trauma patients, and scrotal trauma is particularly prevalent in males 10 to 30 years of age. Prompt diagnosis and timely surgical intervention are essential to prevent future complications of infertility, delayed orchiectomy, infection, and testicular atrophy. While clinical examination provides valuable information, it may be inconclusive due to soft tissue swelling and difficult to perform due to testicular pain with palpation. Conversely, testicular rupture does not always present with pain or tenderness...
October 28, 2017: Current Urology Reports
https://www.readbyqxmd.com/read/29080225/molecular-correlates-in-urine-for-the-obesity-and-prostatic-inflammation-of-bph-luts-patients
#10
Pradeep Tyagi, Saundra S Motley, Tatsuki Koyama, Mahendra Kashyap, Jeffrey Gingrich, Naoki Yoshimura, Jay H Fowke
PURPOSE: Benign prostatic hyperplasia (BPH) is strongly associated with obesity and prostatic tissue inflammation, but the molecular underpinning of this relationship is not known. Here, we examined the association between urine levels of chemokines/adipokines with histological markers of prostate inflammation, obesity, and lower urinary tract symptoms LUTS in BPH patients. METHODS: Frozen urine specimens from 207 BPH/LUTS patients enrolled in Nashville Men's Health Study were sent for blinded analysis of 11 analytes, namely sIL-1RA, CXC chemokines (CXCL-1, CXCL-8, CXCL-10), CC chemokines (CCL2, CCL3, CCL5), PDGF-BB, interleukins IL-6, IL-17, and sCD40L using Luminex™ xMAP® technology...
October 27, 2017: Prostate
https://www.readbyqxmd.com/read/29027898/surgery-versus-antibiotics-for-uncomplicated-appendicitis-which-would-a-medical-student-want
#11
Alison R Althans, Pierre Tamer, Justin T Brady, Emily Steinhagen, Vanessa P Ho
BACKGROUND: Recent data suggest that treatment of acute, uncomplicated appendicitis (AUA) with antibiotics is as effective as surgery. A 2015 study indicated that more than 50% of patients would choose antibiotic therapy. Medical students represent a unique population of potential patients with greater medical knowledge than the general public and possibly less bias than practicing physicians. Therefore, we aimed to evaluate what the MEDICAL STUDENT'S treatment choice for AUA would be and what factors influence these decisions...
October 13, 2017: Surgical Infections
https://www.readbyqxmd.com/read/28959151/a-discussion-on-the-aua-castrateresistant-prostate-cancer-guidelines
#12
David M Albala, David F Penson
No abstract text is available yet for this article.
2017: Reviews in Urology
https://www.readbyqxmd.com/read/28959147/the-american-urological-association-s-prostate-cancer-screening-guideline-which-cancers-will-be-missed-in-average-risk-men-aged-40-to-54-years
#13
Thomas E Moody, Curtis L Spraitzar, Elizabeth Eisenhart, Scott Tully
To determine the impact of the American Urological Association's (AUA) guideline for early detection of prostate cancer that recommends against routine screening in men aged 40 to 54 years at average risk (eg, white men without a family history of prostate cancer), we undertook a study of 973 men who previously underwent a prostate biopsy at Urology Centers of Alabama (UCA) over the 5-year period from 2010 to 2014. We retrospectively reviewed the results of the prostate biopsies performed by urologists at UCA-and, where applicable, the final surgical pathology results and compared the results by race and family history...
2017: Reviews in Urology
https://www.readbyqxmd.com/read/28921833/guideline-of-guidelines-asymptomatic-microscopic-haematuria
#14
REVIEW
Brian J Linder, Edward J Bass, Hugh Mostafid, Stephen A Boorjian
The aim of the present study was to review major organizational guidelines on the evaluation and management of asymptomatic microscopic haematuria (AMH). We reviewed the haematuria guidelines from: the American Urological Association; the consensus statement by the Canadian Urological Association, Canadian Urologic Oncology Group and Bladder Cancer Canada; the American College of Physicians; the Joint Consensus Statement of the Renal Association and British Association of Urological Surgeons; and the National Institute for Health and Care Excellence...
September 16, 2017: BJU International
https://www.readbyqxmd.com/read/28915666/ard1-mediated-aurora-kinase-a-acetylation-promotes-cell-proliferation-and-migration
#15
Tam Thuy Lu Vo, Ji-Hyeon Park, Ji Hae Seo, Eun Ji Lee, Hoon Choi, Sung-Jin Bae, Hoang Le, Sunho An, Hye Shin Lee, Hee-Jun Wee, Kyu-Won Kim
Aurora kinase A (AuA) is a prerequisite for centrosome maturation, separation, and mitotic spindle assembly, thus, it is essential for cell cycle regulation. Overexpression of AuA is implicated in poor prognosis of many types of cancer. However, the regulatory mechanisms underlying the functions of AuA are still not fully understood. Here, we report that AuA colocalizes with arrest defective protein 1 (ARD1) acetyltransferase during cell division and cell migration. Additionally, AuA is acetylated by ARD1 at lysine residues at positions 75 and 125...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28914580/if2-and-unique-features-of-initiator-trna-fmet-help-establish-the-translational-reading-frame
#16
Bappaditya Roy, Qi Liu, Shinichiro Shoji, Kurt Fredrick
Translation begins at AUG, GUG, or UUG codons in bacteria. Start codon recognition occurs in the P site, which may help explain this first-position degeneracy. However, the molecular basis of start codon specificity remains unclear. In this study, we measured the codon dependence of 30S•mRNA•tRNA(fMet) and 30S•mRNA•tRNA(Met) complex formation. We found that complex stability varies over a large range with initiator tRNA(fMet), following the same trend as reported previously for initiation rate in vivo (AUG > GUG, UUG > CUG, AUC, AUA > ACG)...
September 15, 2017: RNA Biology
https://www.readbyqxmd.com/read/28882031/a-multiregional-italian-cohort-of-24-hour-urine-metabolic-evaluation-in-renal-stone-formers
#17
Francesco Esperto, Martino Marangella, Alberto Trinchieri, Michele Petrarulo, Roberto Miano
BACKGROUND: Nephrolithiasis is a common condition with several studies documenting an increased prevalence over the past four decades. EAU and AUA guidelines recommend 24-hour urine metabolic evaluation in high-risk stone formers. Aim of this study is to retrospectively evaluate the first three years of experience with Lithotest® (Biohealth Italia Srl, Turin, Italy) through the analysis of demographic, clinical and biochemical data collected from a large cohort of patients with kidney stones...
September 7, 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/28845951/-american-urological-association-guideline-for-diagnosis-and-management-of-male-urethral-stricture-2016
#18
REVIEW
A V Zhivov, I A Reva, R L Tedeev, D Yu Pushkar
The article provides coverage of the main features of the American Urological Association (AUA) Guideline for the diagnosis and management of male urethral stricture published in 2016. Clinical guideline on this medical condition is published for the first time and is unique in the world of urology. The authors present their comments based on the accumulated experience of diagnosis and treatment of this urological condition.
July 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28842209/longitudinal-gender-disparity-in-female-urology-resident-primary-authorship-at-an-american-urological-association-sectional-meeting
#19
Tony R Lin, Neil J Kocher, Adam P Klausner, Jay D Raman
OBJECTIVE: To further evaluate the academic representation of female urology residents in the United States, we reviewed abstracts from the Mid-Atlantic American Urological Association (MA-AUA) sectional meetings to determine if the recent increase in the number of female urology residents mirrored an increase in this group's abstract authorship. MATERIALS AND METHODS: Full text abstracts from the MA-AUA meetings were analyzed from 2008 to 2014 excluding 1 joint section meeting...
August 24, 2017: Urology
https://www.readbyqxmd.com/read/28834167/feasibility-and-safety-of-focal-irreversible-electroporation-as-salvage-treatment-for-localized-radio-recurrent-prostate-cancer
#20
Matthijs J Scheltema, Willemien van den Bos, Amila R Siriwardana, Anton M F Kalsbeek, James E Thompson, Francis Ting, Maret Böhm, Anne-Maree Haynes, Ron Shnier, Warick Delprado, Phillip D Stricker
OBJECTIVES: To evaluate the feasibility, safety, early quality-of-life (QoL) and oncological outcomes of salvage focal irreversible electroporation (IRE) for radio-recurrent prostate cancer (PCa). PATIENTS AND METHODS: Patients with localized, radio-recurrent PCa without evidence of metastatic or nodal disease were offered focal IRE according to the consensus guidelines. Patients with a minimum follow-up of 6 months were eligible for analysis. Adverse events were monitored using the National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE version 4...
November 2017: BJU International
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