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https://www.readbyqxmd.com/read/29933521/next-generation-sequencing-improves-treatment-efficacy-and-reduces-hospitalization-in-children-with-drug-resistant-epilepsy
#1
Jing Peng, Nan Pang, Ying Wang, Xiao-Le Wang, Jian Chen, Juan Xiong, Pan Peng, Can-Hui Zhu, Miriam Barakael Kessi, Fang He, Fei Yin
BACKGROUND: The purposes of this study were three-fold: (i) to determine the contribution of known genes to the causation of a broad-spectrum of pediatric drug-resistant epilepsy (DRE), (ii) to compare the diagnostic yield and cost among different next-generation sequencing (NGS) approaches, and especially (iii) to assess how NGS approaches can benefit patients by improving diagnosis and treatment efficiency. METHODS: This study enrolled 273 pediatric DRE patients with no obvious acquired etiology...
June 22, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29933520/bioactivity-guided-isolation-of-anti-inflammatory-constituents-of-the-rare-mushroom-calvatia-nipponica-in-lps-stimulated-raw264-7-macrophages
#2
Seulah Lee, Dahae Lee, Joo Chan Lee, Ki Sung Kang, Rhim Ryoo, Hyun-Ju Park, Ki Hyun Kim
Calvatia species, generally known as puffball mushrooms, are used both as sources of food as well as traditional medicine. Among the Calvatia genus, Calvatia nipponica (Agaricaceae) is one of the rarest species. Using bioassay-guided fractionation based on anti-inflammatory effects, five alkaloids (1 - 5), two phenolics (6 - 7) and a fatty acid methyl ester (8) were isolated from the fruiting bodies of C. nipponica. Compound 8 was identified from C. nipponica for the first time, and all isolates (1 - 8) were tested for inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264...
June 22, 2018: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29933512/protein-kinase-d-displays-intrinsic-tyr-autophosphorylation-activity-insights-into-mechanism-and-regulation
#3
Mathias Cobbaut, Rita Derua, Peter J Parker, Etienne Waelkens, Veerle Janssens, Johan Van Lint
The protein kinase D (PKD) family is regulated through multi-site phosphorylation, including autophosphorylation. For example, PKD displays in vivo autophosphorylation on Ser-742 (and Ser-738 in vitro) in the activation loop and Ser-910 in the C-tail (hPKD1 numbering). In this paper, we describe the surprising observation that PKD also displays in vitro autocatalytic activity towards a Tyr residue in the P+1 loop of the activation segment. We define the molecular determinants for this unusual activity and identify a Cys residue (C705 in PKD1) in the catalytic loop as of utmost importance...
June 22, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29933509/impact-of-aura-and-status-migrainosus-on-readmissions-for-vascular-events-after-migraine-admission
#4
Lili Velickovic Ostojic, John W Liang, Huma U Sheikh, Mandip S Dhamoon
OBJECTIVE: -To estimate readmission rates for acute ischemic stroke (AIS), transient ischemic attack (TIA), subarachnoid hemorrhage, and intracerebral hemorrhage after an index admission for migraine, using nationally representative data. METHODS: -The Nationwide Readmissions Database was designed to analyze readmissions for all payers and uninsured, with data on >14 million US admissions in 2013. We used International Classification of Diseases, Ninth Revision, Clinical Modification codes to identify index migraine admissions with and without aura or status migrainosus, and readmissions for cerebrovascular events...
June 22, 2018: Headache
https://www.readbyqxmd.com/read/29933506/pharmacodynamic-analysis-of-eribulin-safety-in-breast-cancer-patients-using-real-world-post-marketing-surveillance-data
#5
Takahisa Kawamura, Hidefumi Kasai, Valentina Fermanelli, Toshiaki Takahashi, Yukinori Sakata, Toshiyuki Matsuoka, Mika Ishii, Yusuke Tanigawara
Post-marketing surveillance is useful to collect safety data in real-world clinical settings. In this study, we firstly applied the post-marketing real-world data on a mechanistic model analysis for neutropenic profiles of eribulin in patients with recurrent or metastatic breast cancer (RBC/MBC). Demographic and safety data were collected using an active surveillance method from eribulin-treated RBC/MBC patients. Changes in neutrophil counts over time were analyzed using a mechanistic pharmacodynamic model...
June 22, 2018: Cancer Science
https://www.readbyqxmd.com/read/29933505/cannulation-method-for-intra-diverticular-papilla-with-long-oral-protrusion-using-biopsy-forceps-for-axis-alignment
#6
Mamoru Takenaka, Kosuke Minaga, Masatoshi Kudo
Intra-diverticular papilla is considered as a difficult anatomical orientation for biliary cannulation. 1 2 3 To our knowledge, this is the first report to show the usefulness of biopsy forceps for cannulation not only to expose the ampulla in the case of an intra-diverticular papilla but also for axis alignment.An 85-year-old woman underwent endoscopic retrograde cholangiopancreatography for a common bile duct (CBD) stone. A duodenoscope (TJF TYPE 260V; Olympus Medical Systems, Tokyo, Japan) was inserted into Vater's papilla...
June 22, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29933504/unique-variant-of-nod2-pediatric-granulomatous-arthritis-with-severe-1-25-dihydroxyvitamin-d-mediated-hypercalcemia-and-generalized-osteosclerosis
#7
Michael P Whyte, Emilina Lim, William H McAlister, Gary S Gottesman, Lien Trinh, Deborah J Veis, Vinieth N Bijanki, Matthew G Boden, Angela Nenninger, Steven Mumm, David Buchbinder
Pediatric granulomatous arthritis (PGA) refers to two formerly separate entities; autosomal dominant Blau syndrome (BS) and its sporadic phenocopy early-onset sarcoidosis (EOS). In 2001 BS and in 2005 EOS became explained by heterozygous mutations within the gene that encodes nucleotide-binding oligomerization domain-containing protein 2 (NOD2), also called caspase recruitment domain-containing protein 15 (CARD15). NOD2 is a microbe sensor in leukocyte cytosol that activates and regulates inflammation. PGA is characterized by a triad of auto-inflammatory problems (dermatitis, uveitis, and arthritis) in early childhood, which suggests the causal NOD2/CARD15 mutations are activating defects...
June 22, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29933501/decreased-hip-lower-leg-and-humeral-fractures-but-increased-forearm-fractures-in-highly-active-individuals
#8
Karl Stattin, Ulf Hållmarker, Johan Ärnlöv, Stefan James, Karl Michaëlsson, Liisa Byberg
It is not known how physical exercise affects the risk of different types of fractures, especially in highly active individuals. To investigate this association, we studied a cohort of 118,204 men and 71,757 women who from 1991 to 2009 participated in Vasaloppet, a long-distance cross-country skiing race in Sweden, and 505,194 nonparticipants frequency-matched on sex, age, and county of residence from the Swedish population. Participants ranged from recreational exercisers to world-class skiers. Race participation, distance of race run, number of races participated in, and finishing time were used as proxies for physical exercise...
June 22, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29933488/external-memory-aid-preferences-of-individuals-with-mild-memory-impairments
#9
Alyssa Lanzi, Sarah E Wallace, Michelle S Bourgeois
Individuals with mild memory impairments often rely on external memory aids (EMAs) to compensate for impaired cognitive abilities and to support independent completion of activities of daily living. These strategies are evidence based; however, professionals have limited knowledge regarding individual preferences and guidance on how to incorporate a person-centered approach into the EMA development phase. The purpose of the current study was to qualitatively investigate individuals' preferences and experiences as they relate to EMAs...
July 2018: Seminars in Speech and Language
https://www.readbyqxmd.com/read/29933483/-lung-resection-after-definitive-and-neo-adjuvant-chemoradiation-for-stage-iiia-b-locally-advanced-non-small-cell-lung-cancer-a-retrospective-analysis
#10
Waldemar Schreiner, Sofiia Gavrychenkova, Wojciech Dudek, Sebastian Lettmaier, Ralf Rieker, Rainer Fietkau, Horia Sirbu
BACKGROUND: The outcomes of so called "salvage" resections after definitive chemoradiation vs. curative resections after neoadjuvant chemoradiation therapy (IT-resection) in patients with stage IIIA/B locally advanced non-small cell lung cancer have rarely been compared. The aim of our study was to compare perioperative results, postoperative and recurrence-free survival and to identify relevant prognostic survival factors for both therapy strategies. PATIENTS AND METHODS: Between June 2008 and May 2017, 43 patients underwent pulmonary resection following induction therapy (group 1) and 14 patients underwent salvage resection after definitive chemoradiation (group 2)...
June 2018: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/29933462/protective-effects-of-an-obesity-associated-polymorphism-cdkal1-rs9356744-on-prediabetes-the-cardiometabolic-risk-in-chinese-crc-study
#11
J Liang, Y Zhu, X-K Liu, Q-Q Qiu, Y-T Sun, Y Wang, Y Pei, M-Q Yang, L Qi
BACKGROUND: Obesity is strongly associated with insulin resistance and elevated plasma glucose levels. The rs9356744 polymorphism in the CDKAL1 gene is associated with body mass index (BMI) only in East Asians. Here, we examined the effect of the rs9356744 polymorphism on glucose-related traits and prediabetes in Chinese adults. METHODS: A total of 2 357 participants were enrolled from the Cardiometabolic Risk in Chinese (CRC) Study, including 499 persons with prediabetes, 204 persons with type 2 diabetes, and 1 654 normoglycemic controls...
June 22, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29933444/black-clouds-vs-random-variation-in-hospital-admissions
#12
Luei Wern Ong, Jeffrey D Dawson, John W Ely
BACKGROUND AND OBJECTIVES: Physicians often accuse their peers of being "black clouds" if they repeatedly have more than the average number of hospital admissions while on call. Our purpose was to determine whether the black-cloud phenomenon is real or explainable by random variation. METHODS: We analyzed hospital admissions to the University of Iowa family medicine service from July 1, 2010 to June 30, 2015. Analyses were stratified by peer group (eg, night shift attending physicians, day shift senior residents)...
June 2018: Family Medicine
https://www.readbyqxmd.com/read/29933438/primary-surgical-repair-of-coarctation-of-the-aorta-in-adolescents-and-adults-intermediate-results-and-consequences-of-hypertension
#13
Bijoy G Rajbanshi, Dikshya Joshi, Sidhartha Pradhan, Navin C Gautam, Rabindra Timala, Urmila Shakya, Apurb Sharma, Gangaram Biswakarma, Jyotindra Sharma
OBJECTIVES: Coarctation of the aorta is known to present with hypertension in older patients; we reviewed our experience and assessed the outcome of hypertension following surgical correction. METHODS: From April 2004 to date, 43 patients above the age of 12 underwent coarctation of the aorta repair. The mean age was 20.4 + 9.7 years (maximum 56 years); 21 (48.8%) were older than 18 years and 28 (65.1%) were men. Thirty (69.8%) patients had hypertension...
June 22, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29933437/emergence-of-integrase-resistance-mutations-during-initial-therapy-containing-dolutegravir
#14
Jennifer A Fulcher, Yushen Du, Tian-Hao Zhang, Ren Sun, Raphael J Landovitz
Dolutegravir (DTG) is a preferred drug for initial treatment of human immunodeficiency virus type 1 infection. We present next-generation sequencing analysis of integrase genotypes during a period of virologic failure in a treatment-naive man who initiated tenofovir disoproxil fumarate/emtricitabine plus DTG.
March 21, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29933436/smoking-cessation-and-risk-of-esophageal-cancer-by-histological-type-systematic-review-and-meta-analysis
#15
Qiao-Li Wang, Shao-Hua Xie, Wen-Tao Li, Jesper Lagergren
Background: Tobacco smoking strongly increases risk of esophageal squamous cell carcinoma and moderately increases risk of esophageal adenocarcinoma. How smoking cessation influences esophageal cancer risk across histological subtypes, time latencies, and geographic regions is not clear. Methods: Studies were systematically searched on Medline, Embase, Web of Science, Cochrane Library, and ClinicalTrials.gov. Pooled estimates of risk ratios (RRs) were derived using a random effects model...
December 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29933433/comparison-of-the-survival-between-coronary-artery-bypass-graft-surgery-versus-percutaneous-coronary-intervention-in-patients-with-poor-left-ventricular-function-ejection-fraction-30-a-propensity-matched-analysis
#16
Shaneel Shah, Umberto Benedetto, Massimo Caputo, Gianni D Angelini, Hunaid A Vohra
OBJECTIVES: Existing evidence comparing the outcomes of coronary artery bypass graft (CABG) surgery versus percutaneous coronary intervention (PCI) in patients with poor left ventricular function (LVF) is sparse and flawed. This is largely due to patients with poor LVF being underrepresented in major research trials and the outdated nature of some studies that do not consider drug-eluting stent PCI. METHODS: Following strict inclusion criteria, 717 patients who underwent revascularization by CABG or PCI between 2002 and 2015 were enrolled...
June 22, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29933429/effect-of-currency-exchange-rate-fluctuations-on-aid-effectiveness-in-the-health-sector-in-zambia
#17
Collins Chansa, Jesper Sundewall, Numi Östlund
Development assistance for health (DAH) remains a significant and important source of health financing in many low and lower middle-income countries. However, this assistance has not been fully effective. This study explores the effect of currency exchange rate fluctuations on volatility of DAH in Zambia using a mixed methods approach. Data covering the period 1997-2008 were collected from various financial and programmatic reports, while six key informant interviews were conducted to validate and translate findings from the quantitative analysis...
June 22, 2018: Health Policy and Planning
https://www.readbyqxmd.com/read/29933414/assessment-of-indicators-and-experiences-of-pain-and-pleasure-in-family-health-teams-based-on-the-psychodynamics-of-work
#18
Cecília Helena Glanzner, Agnes Olschowsky, Daiane Dal Pai, Juliana Petri Tavares, Deisi Angélica Hoffman
OBJECTIVE: To evaluate indicators and experiences of pain and pleasure among workers of the family health teams based on the theoretical and methodological framework Psychodynamics of Work. METHOD: This is a mixed-method study with 153 workers from the multiprofessional family health team of 12 health units in Porto Alegre. All the participants answered the Pleasure and Pain in the Workplace Scale ("EIPST") between September and November 2011 and 68 also participated in the collective interviews between October and December 2012...
June 7, 2018: Revista Gaúcha de Enfermagem
https://www.readbyqxmd.com/read/29933411/time-trends-in-dyspepsia-and-association-with-h-pylori-and-work-related-stress-an-observational-study-in-white-collar-employees-in-1996-and-2015
#19
Stefanie Braig, Simon Berger, David Rothenbacher, Stefanie Schmid, Thomas Seufferlein, Hermann Brenner, Dietrich Rothenbacher, Harald Gündel
PURPOSE: We aimed to describe time trends in functional dyspepsia and the association of dyspepsia-related factors, Helicobacter pylori (H. pylori) and work-related stress with functional dyspepsia in white collar employees in 1996 and 2015. MATERIALS AND METHODS: Repeat cross-sectional study conducted in 1996 (n = 190, response rate = 76.1) and 2015 (n = 195, response rate = 40.2) within a health insurance company in South-West Germany. Dyspeptic symptoms measured according to the Rome III criteria, effort-reward imbalance and further work- or dyspepsia-related factors were assessed by self-administered questionnaire...
2018: PloS One
https://www.readbyqxmd.com/read/29933406/anemia-modifies-the-prognostic-value-of-glycated-hemoglobin-in-patients-with-diabetic-chronic-kidney-disease
#20
I-Ching Kuo, Hugo You-Hsien Lin, Sheng-Wen Niu, Jia-Jung Lee, Yi-Wen Chiu, Chi-Chih Hung, Shang-Jyh Hwang, Hung-Chun Chen
A common complication of chronic kidney disease (CKD), anemia can influence glycated hemoglobin (HbA1c) levels. In diabetic patients, anemia occurs earlier and with higher severity over the course of CKD stages. To elucidate the effect of hemoglobin (Hb) on the predictive value of HbA1c, we enrolled 1558 diabetic patients with stages 3-4 CKD, categorized according to baseline Hb and HbA1c quartiles. Linear regression revealed that higher HbA1c correlated significantly with higher Hb in the Hb < 10 g/dL group (β = 0...
2018: PloS One
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