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https://www.readbyqxmd.com/read/28734273/association-between-thrombophilic-genes-polymorphisms-and-recurrent-pregnancy-loss-susceptibility-in-the-iranian-population-a-systematic-review-and-meta-analysis
#1
Mahdieh Kamali, Sedigheh Hantoushzadeh, Sedigheh Borna, Hossein Neamatzadeh, Mahta Mazaheri, Mahmood Noori-Shadkam, Fatemeh Haghighi
Background: Studies have indicated that thrombophilic genes polymorphisms are associated with recurrent pregnancy loss (RPL) in the Iranian population. However, the results from these studies remained inconsistent and inconclusive. The aim of this systematic review and meta-analysis was to evaluate the precise association between thrombophilic genes polymorphisms (MTHFR C677T, MTHFR A1298C, Prothrombin G20210A, FVL G1691A, and PAI-1 4G/5G) and RPL risk in the Iranian population. Method: Electronic databases of PubMed, Web of Science, Google Scholar, and ISC were searched for eligible articles published up to April 1, 2017...
July 23, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28734272/glycosylation-patterns-of-selected-proteins-in-individual-serum-and-cerebrospinal-fluid-samples
#2
Isabella Karlsson, Lorena Ndreu, Alessandro Quaranta, Gunnar Thorsén
A method we previously developed has been applied to the determination of the glycosylation pattern of specific proteins in biological samples. Six proteins (alpha-1-antitrypsin, transferrin, haptoglobin, C1 inhibitor, alpha-1 acid glycoprotein, and immunoglobulin G) were studied in serum samples from five individuals and cerebrospinal fluid (CSF) samples from three individuals, to investigate the expected normal distribution of glycosylation patterns and to assess whether this methodology can be used to discriminate between samples from different individuals...
April 25, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28734271/development-and-validation-of-sensitive-lc-ms-ms-method-for-the-quantification-of-suvn-502-and-its-metabolite-and-its-application-for-first-in-human-pharmacokinetic-study
#3
Ramakrishna Nirogi, Devender Reddy Ajjala, Raghupathi Aleti, Lakshmiprasanna Rayapati, Hanumanth Rao Pantangi, Rajesh Kumar Boggavarapu, Naga Surya Prakash Padala
A sensitive and rapid LC-MS/MS method was developed and validated for the quantification of SUVN-502 and M1 of SUVN-502, a 5-HT6 receptor antagonist for the treatment of dementia associated with Alzheimer's disease. Following solid-phase extraction, SUVN-502 and M1 of SUVN-502 and IS were eluted with 10mM ammonium acetate (pH 4.0) and acetonitrile using a rapid gradient program on reverse phase column. Multiple reaction monitoring mode was used to monitor the respective transitions of m/z 478.2→377.7 for SUVN-502 and m/z 464...
April 14, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28734267/status-epilepticus-related-etiology-incidence-and-mortality-a-meta-analysis
#4
Rui-Juan Lv, Qun Wang, Tao Cui, Fei Zhu, Xiao-Qiu Shao
Status epilepticus (SE) is a severe medical condition. To determine its epidemiology and outcome of SE, we performed a meta-analysis to investigate the etiology, incidence and mortality of SE. We searched PubMed and Embase between Jan 1, 2000, and Oct 31, 2016, with no regional restrictions, for observational studies of the etiology, incidence and mortality of SE. Forty-three studies were included in the meta-analysis. The pooled crude annual incidence rate, the pooled case fatality rate and the pooled crude annual mortality rate of SE were 12...
July 15, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28734266/air-quality-and-health-effects-of-biogenic-volatile-organic-compounds-emissions-from-urban-green-spaces-and-the-mitigation-strategies
#5
Yuan Ren, Zelong Qu, Yuanyuan Du, Ronghua Xu, Danping Ma, Guofu Yang, Yan Shi, Xing Fan, Akira Tani, Peipei Guo, Ying Ge, Jie Chang
Biogenic volatile organic compounds (BVOCs) emissions lead to fine particulate matter (PM2.5) and ground-level ozone pollution, and are harmful to human health, especially in urban areas. However, most BVOCs estimations ignored the emissions from urban green spaces, causing inaccuracies in the understanding of regional BVOCs emissions and their environmental and health effects. In this study, we used the latest local vegetation datasets from our field survey and applied an estimation model to analyze the spatial-temporal patterns, air quality impacts, health damage and mitigating strategies of BVOCs emissions in the Greater Beijing Area...
July 19, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28734265/decreased-lung-function-with-mediation-of-blood-parameters-linked-to-e-waste-lead-and-cadmium-exposure-in-preschool-children
#6
Xiang Zeng, Xijin Xu, H Marike Boezen, Judith M Vonk, Weidong Wu, Xia Huo
Blood lead (Pb) and cadmium (Cd) levels have been associated with lower lung function in adults and smokers, but whether this also holds for children from electronic waste (e-waste) recycling areas is still unknown. To investigate the contribution of blood heavy metals and lung function levels, and the relationship among living area, the blood parameter levels, and the lung function levels, a total of 206 preschool children from Guiyu (exposed area), and Haojiang and Xiashan (reference areas) were recruited and required to undergo blood tests and lung function tests during the study period...
July 19, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28734264/a-small-scale-portable-method-for-extracting-microplastics-from-marine-sediments
#7
Rachel L Coppock, Matthew Cole, Penelope K Lindeque, Ana M Queirós, Tamara S Galloway
Microplastics (plastic particles, 0.1 μm-5 mm in size) are widespread marine pollutants, accumulating in benthic sediments and shorelines the world over. To gain a clearer understanding of microplastic availability to marine life, and the risks they pose to the health of benthic communities, ecological processes and food security, it is important to obtain accurate measures of microplastic abundance in marine sediments. To date, methods for extracting microplastics from marine sediments have been disadvantaged by complexity, expense, low extraction efficiencies and incompatibility with very fine sediments...
July 19, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28734262/mercury-risk-in-poultry-in-the-wanshan-mercury-mine-china
#8
Runsheng Yin, Wei Zhang, Guangyi Sun, Zhaohui Feng, James P Hurley, Liyuan Yang, Lihai Shang, Xinbin Feng
In this study, total mercury (THg) and methylmercury (MeHg) concentrations in muscles (leg and breast), organs (intestine, heart, stomach, liver) and blood were investigated for backyard chickens, ducks and geese of the Wanshan Mercury Mine, China. THg in poultry meat products range from 7.9 to 3917.1 ng/g, most of which exceeded the Chinese national standard limit for THg in meat (50 ng/g). Elevated MeHg concentrations (0.4-62.8 ng/g) were also observed in meat products, suggesting that poultry meat can be an important human MeHg exposure source...
July 19, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28734260/time-averaged-concentrations-are-effective-for-predicting-chronic-toxicity-of-varying-copper-pulse-exposures-for-two-freshwater-green-algae-species
#9
Brad M Angel, Stuart L Simpson, Ellissah Granger, Kathryn Goodwyn, Dianne F Jolley
Intermittent, fluctuating and pulsed contaminant discharges may result in organisms receiving highly variable contaminant exposures. This study investigated the effects of dissolved copper pulse concentration and exposure duration on the toxicity to two freshwater green algae species. The effects of single copper pulses of between 1 and 48 h duration and continuous exposures (72 h) on growth rate inhibition of Pseudokirchneriella subcapitata and Chlorella sp. were compared on a time-averaged concentration (TAC) basis...
July 19, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28734255/use-of-electronic-cigarettes-in-public-and-private-settings-in-barcelona-spain
#10
Nuria Matilla-Santander, Marcela Fu, Montse Ballbè, Kailey Bunch, Cristina Lidón-Moyano, Juan Carlos Martín-Sánchez, Esteve Fernández, Jose M Martínez-Sánchez
OBJECTIVES: To describe the prevalence of e-cigarette users who use them in selected indoor public and workplaces, and private venues in Barcelona (Spain) in 2015. METHODS: This is a cross-sectional study of a sample of e-cigarette users (≥ 18 years) from Barcelona (n = 600). We calculated the proportion of e-cigarette users who used the device in public and private settings (in the last 30 days). We fit multivariate logistic regression models adjusted for sex and age to calculate the odds ratios (OR) with their 95% confidence intervals (CI) of e-cigarette use by socio-demographic factors, dual use and nicotine-containing e-cigarettes...
July 19, 2017: Environmental Research
https://www.readbyqxmd.com/read/28734254/childhood-polybrominated-diphenyl-ether-pbde-exposure-and-neurobehavior-in-children-at-8-years
#11
Ann M Vuong, Kimberly Yolton, Changchun Xie, Glenys M Webster, Andreas Sjödin, Joseph M Braun, Kim N Dietrich, Bruce P Lanphear, Aimin Chen
BACKGROUND: Prenatal polybrominated diphenyl ether (PBDE) exposure has been associated with decrements in IQ and increased attention deficit/hyperactivity disorder related behaviors in children; however, data are limited for the role of postnatal exposures. OBJECTIVES: We investigated the association between a series of childhood PBDE concentrations and Full-Scale Intelligence Quotient (FSIQ) and externalizing problems at 8 years. METHODS: We used data from 208 children in the Health Outcomes and Measures of the Environment (HOME) Study, a prospective pregnancy and birth cohort...
July 19, 2017: Environmental Research
https://www.readbyqxmd.com/read/28734252/river-sequesters-atmospheric-carbon-and-limits-the-co2-degassing-in-karst-area-southwest-china
#12
Tao Zhang, Jianhong Li, Junbing Pu, Jonathan B Martin, Mitra B Khadka, Feihong Wu, Li Li, Feng Jiang, Siyu Huang, Daoxian Yuan
CO2 fluxes across water-air interfaces of river systems play important roles in regulating the regional and global carbon cycle. However, great uncertainty remains as to the contribution of these inland water bodies to the global carbon budget. Part of the uncertainty stems from limited understanding of the CO2 fluxes at diurnal and seasonal frequencies caused by aquatic metabolism. Here, we measured surface water characteristics (temperature, pH, and DO, DIC, Ca(2+) concentrations) and CO2 fluxes across the air-water interface at two transects of Guijiang River, southwest China to assess the seasonal and diurnal dynamics of fluvial carbon cycling and its potential role in regional and global carbon budgets...
July 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28734250/assessment-of-direct-exposure-and-leaching-risk-from-pahs-in-roadway-and-stormwater-system-residuals
#13
Edmund Azah, Hwidong Kim, Timothy Townsend
Wastes generated from municipal cleaning activities such as street sweeping, ditch cleaning, stormwater pond maintenance, and catch basin sediment removal require appropriate management. Beneficial use of these types of waste is a good alternative to landfilling; however, there are genuine concerns about possible soil and groundwater contamination by pollutants such as polycyclic aromatic hydrocarbons (PAHs). This study assessed the potential risks associated with beneficial use of roadway and stormwater system residuals collected from 14 cities across the state of Florida, USA...
July 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28734245/azaphenothiazines-promising-phenothiazine-derivatives-an-insight-into-nomenclature-synthesis-structure-elucidation-and-biological-properties
#14
REVIEW
Krystian Pluta, Małgorzata Jeleń, Beata Morak-Młodawska, Michał Zimecki, Jolanta Artym, Maja Kocięba, Ewa Zaczyńska
For the last two decades, classical phenothiazines have attracted attention of researchers, as the hitherto investigations have revealed many significant biological activities within this class of compounds, other than originally discovered neuroleptic ones. Important, new pharmaceutical results on phenothiazines, as 10-substituted dibenzothiazines, were recently highlighted in several reviews. Azaphenothiazines are structurally modified phenothiazines by substitution of one or both benzene rings in the phenothiazine ring system with the azine rings, such as: pyridine, pyridazine, pyrimidine, pyrazine, 1,2,4-triazine, quinoline, quinoxaline, benzoxazine and benzothiazine...
July 8, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28734243/caveolin-1-related-autophagy-initiated-by-aldosterone-induced-oxidation-promotes-liver-sinusoidal-endothelial-cells-defenestration
#15
Xiaoying Luo, Dan Wang, Xuan Luo, Xintao Zhu, Guozhen Wang, Zuowei Ning, Yang Li, Xiaoxin Ma, Renqiang Yang, Siyi Jin, Yun Huang, Ying Meng, Xu Li
Aldosterone, with pro-oxidation and pro-autophagy capabilities, plays a key role in liver fibrosis. However, the mechanisms underlying aldosterone-promoted liver sinusoidal endothelial cells (LSECs) defenestration remain unknown. Caveolin 1 (Cav1) displays close links with autophagy and fenestration. Hence, we aim to investigate the role of Cav1-related autophagy in LSECs defenestration. We found the increase of aldosterone/MR (mineralocorticoid receptor) level, oxidation, autophagy, and defenestration in LSECs in the human fibrotic liver, BDL or hyperaldosteronism models; while antagonizing aldosterone or inhibiting autophagy relieved LSECs defenestration in BDL-induced fibrosis or hyperaldosteronism models...
July 13, 2017: Redox Biology
https://www.readbyqxmd.com/read/28734241/entrapment-perceived-burdensomeness-and-thwarted-belongingness-as-predictors-of-suicide-ideation
#16
Thomas Forkmann, Tobias Teismann
The Integrated Motivational-Volitional (IMV) Model of suicide posits that perceived burdensomeness and thwarted belongingness moderate the association between perceptions of entrapment and suicide ideation. However, the proposed moderation is yet to be tested. Possible moderator effects were investigated in an online sample (N = 480; 74% female; Mage = 28.5, SDage = 11.1). Entrapment and perceived burdensomeness predicted suicide ideation. However, neither perceived burdensomeness nor thwarted belongingness moderated the association between entrapment and suicide ideation...
July 16, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28734235/characterization-of-cognitive-performance-and-evaluation-of-quality-of-life-among-patients-with-htlv-1
#17
Liliana Raulino Goncalves, Leopoldo Nelson Fernandes Barbosa, Paula Machado Ribeiro Magalhaes, Pedro Augusto Sampaio Rocha-Filho
OBJECTIVE: To characterize cognitive alterations among patients with HTLV-1, ascertain what is associated with these alterations and evaluate these patients' quality of life. PATIENTS AND METHODS: This was a cross-sectional study. Patients infected by HTLV-1 who were seen at the Oswaldo Cruz University Hospital from March 2014 to June 2015 were included in the study. A semi-structured questionnaire and the Mini-Mental State Examination, Color Trails Test, Wechsler Adult Intelligence Scale (WAIS-III), Hospital Anxiety and Depression Scale and Medical Outcomes Study 36-Item Short-Form Health Survey (SF36) were used...
July 12, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28734233/risk-of-hospitalization-among-survivors-of-childhood-and-adolescent-acute-lymphoblastic-leukemia-compared-to-siblings-and-a-general-population-sample
#18
Judy Y Ou, Rochelle R Smits-Seemann, Sapna Kaul, Mark N Fluchel, Carol Sweeney, Anne C Kirchhoff
BACKGROUND: Acute Lymphoblastic Leukemia (ALL) has a high survival rate, but cancer-related late effects in the early post-treatment years need documentation. Hospitalizations are an indicator of the burden of late effects. We identify rates and risk factors for hospitalization from five to ten years after diagnosis for childhood and adolescent ALL survivors compared to siblings and a matched population sample. METHODS: 176 ALL survivors were diagnosed at ≤22 years between 1998 and 2008 and treated at an Intermountain Healthcare facility...
July 19, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28734230/simultaneous-scanning-tunneling-microscopy-and-synchrotron-x-ray-measurements-in-a-gas-environment
#19
Rik V Mom, Willem G Onderwaater, Marcel J Rost, Maciej Jankowski, Sabine Wenzel, Leon Jacobse, Paul F A Alkemade, Vincent Vandalon, Matthijs A van Spronsen, Matthijs van Weeren, Bert Crama, Peter van der Tuijn, Roberto Felici, Wilhelmus M M Kessels, Francesco Carlà, Joost W M Frenken, Irene M N Groot
A combined X-ray and scanning tunneling microscopy (STM) instrument is presented that enables the local detection of X-ray absorption on surfaces in a gas environment. To suppress the collection of ion currents generated in the gas phase, coaxially shielded STM tips were used. The conductive outer shield of the coaxial tips can be biased to deflect ions away from the tip core. When tunneling, the X-ray-induced current is separated from the regular, 'topographic' tunneling current using a novel high-speed separation scheme...
July 14, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/28734228/effect-of-education-on-ability-of-ai-professionals-and-herd-owner-inseminators-to-detect-cows-not-in-oestrus-and-its-relation-with-progesterone-concentration-on-day-of-re-insemination
#20
K Vartia, J Taponen, J Heikkinen, H Lindeberg
The effect of training background of persons performing artificial insemination (AI) (herd-owner inseminators (OWNER), AI technicians (AI-T), and fertility consultants (FC)) on pregnancy rate and their ability to detect cows not in oestrus were studied. A total of 1584 re-AI occasions on 754 dairy farms were included. Milk samples for progesterone (P4) analysis in all cases were collected, as were data on the herd, previous breeding attempts, oestrous signs, uterine tone, slipperiness of cervix, and co-operation of the cow...
July 13, 2017: Theriogenology
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