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https://www.readbyqxmd.com/read/29401296/changes-in-keratin-8-18-expression-in-human-granulosa-cell-lineage-are-associated-to-cell-death-survival-events-potential-implications-for-the-maintenance-of-the-ovarian-reserve
#1
F Gaytan, C Morales, J Roa, M Tena-Sempere
STUDY QUESTION: Is keratin 8/18 (K8/K18) expression linked to cell death/survival events in the human granulosa cell lineage? SUMMARY ANSWER: A close association exists between changes in K8/K18 expression and cell death/survival events along the human granulosa cell lineage lifespan. WHAT IS KNOWN ALREADY: In addition to their structural and mechanical functions, K8/K18 play essential roles regulating cell death, survival and differentiation in several non-gonadal epithelial tissues...
February 1, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29221481/association-of-body-mass-index-with-knee-cartilage-damage-in-an-asymptomatic-population-based-study
#2
Alvin Keng, Eric C Sayre, Ali Guermazi, Savvakis Nicolaou, John M Esdaile, Anona Thorne, Joel Singer, Jacek A Kopec, Jolanda Cibere
BACKGROUND: Cartilage changes are an important early finding of osteoarthritis (OA), which can exist even before symptoms. Our objective was to determine the prevalence of knee cartilage damage on magnetic resonance imaging (MRI) in an asymptomatic population-based cross-sectional study and to evaluate the association of body mass index (BMI) with cartilage damage. METHODS: Subjects, aged 40-79 years, without knee pain (n = 73) were recruited as a random population sample and assessed for BMI (kg/m2), including current BMI (measured), past BMI at age 25 (self-reported) and change in BMI...
December 8, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29145895/comparative-analysis-of-high-sensitivity-cardiac-troponin-i-and-t-for-their-association-with-coronary-computed-tomography-assessed-calcium-scoring-represented-by-the-agatston-score
#3
Jonas Rusnak, Michael Behnes, Thomas Henzler, Nadine Reckord, Nils Vogler, Mathias Meyer, Ursula Hoffmann, Michele Natale, Julia Hoffmann, Sonja Hamed, Kathrin Weidner, Siegfried Lang, Agnibh Mukherji, Holger Haubenreisser, Stefan O Schoenberg, Martin Borggrefe, Thomas Bertsch, Ibrahim Akin
BACKGROUND: This study evaluates the association between high-sensitivity cardiac troponin I (hs-cTnI) and T (hs-cTnT) and coronary calcium concentration (CAC) detected by coronary computed tomography (CCT) and evaluated with the Agatston score in patients with suspected coronary artery disease (CAD). METHODS: Patients undergoing CCT during routine clinical care were enrolled prospectively. CCT was indicated for patients with a low to intermediate pretest probability for CAD...
November 16, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/29112800/the-association-of-femoroacetabular-impingement-and-delayed-gadolinium-enhanced-mri-of-cartilage-dgemric-a-population-based-study
#4
Yimeng Guo, Honglin Zhang, Hong Qian, David R Wilson, Hubert Wong, Morgan Barber, Bruce B Forster, John Esdaile, Jolanda Cibere
OBJECTIVE: 1) To assess the association of FAI and dGEMRIC T1 relaxation values (RV). 2) To evaluate whether subtypes of FAI (cam, pincer, mixed) are associated with region-specific dGEMRIC T1 RVs. METHODS: A population-based sample of Caucasian subjects with and without hip pain, aged 20-49, was selected through random digit dialing. A sample of 128 subjects underwent hip joint 3T dGEMRIC scans. Radiographic cam FAI was defined as an alpha angle >55°, while pincer FAI was defined by a lateral center edge angle >40° or a positive cross-over sign...
November 7, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28472071/associations-between-mri-features-versus-knee-pain-severity-and-progression-data-from-the-vancouver-longitudinal-study-of-early-knee-osteoarthritis
#5
Eric C Sayre, Ali Guermazi, John M Esdaile, Jacek A Kopec, Joel Singer, Anona Thorne, Savvas Nicolaou, Jolanda Cibere
OBJECTIVE: To determine associations between features of osteoarthritis (OA) on MRI and knee pain severity and knee pain progression. DESIGN: Baseline, 3.3- and 7.5-year assessments were performed for 122 subjects with baseline knee pain (age 40-79), sample-weighted for population (with knee pain) representativeness. MRIs were scored for: osteophytes (0:absent to 3:large); cartilage (0:normal to 4:full thickness defect; 0/1 collapsed); subchondral sclerosis (0:none to 3:>50% of site), subchondral cyst (0:absent to 3:severe), bone marrow lesions (0:none to 3:≥50% of site); and meniscus (0:normal to 3:maceration/resection), in 6-8 regions each...
2017: PloS One
https://www.readbyqxmd.com/read/28359798/effect-of-high-valency-pneumococcal-conjugate-vaccines-on-invasive-pneumococcal-disease-in-children-in-spidnet-countries-an-observational-multicentre-study
#6
Camelia Savulescu, Pavla Krizova, Agnes Lepoutre, Jolita Mereckiene, Didrik F Vestrheim, Pilar Ciruela, Maria Ordobas, Marcela Guevara, Eisin McDonald, Eva Morfeldt, Jana Kozakova, Emmanuelle Varon, Suzanne Cotter, Brita A Winje, Carmen Munoz-Almagro, Luis Garcia, Jesus Castilla, Andrew Smith, Birgitta Henriques-Normark, Lucia Pastore Celentano, Germaine Hanquet
BACKGROUND: The Streptococcus pneumoniae Invasive Disease network (SpIDnet) actively monitors populations in nine sites in seven European countries for invasive pneumococcal disease. Five sites use 13-valent pneumococcal conjugate vaccine (PCV13) alone and four use the ten-valent PCV (PCV10) and PCV13. Vaccination uptake is greater than 90% in six sites and 67-78% in three sites. We measured the effects of introducing high-valency PCVs on the incidence of invasive pneumococcal disease in children younger than 5 years...
August 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28219714/relationship-between-physical-activity-and-hip-pain-in-persons-with-and-without-cam-or-pincer-morphology-a-population-based-case-control-study
#7
J A Kopec, J Cibere, L C Li, C Zhang, M Barber, H Qian, H Wong, G Steininger, H Prlic, J Simatovic, C Ratzlaff, E C Sayre, J Ye, B B Forster, J M Esdaile
OBJECTIVES: The purpose of the study was to determine if physical activity (PA) is a risk factor for persistent or recurrent hip pain in young and middle-aged persons with and without radiographic findings of cam or pincer morphology (CPM). METHODS: A population sample of persons aged 20-49 with (cases) and without (controls) hip pain in Metro Vancouver, Canada, was selected through random digit dialing (RDD). Self-reported PA was expressed as average energy expenditure (MET-hours) per year, over lifetime...
July 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28181987/-pelfi-project-recruitment-and-sociodemographic-characteristics-of-immigrant-and-autochthonous-families-from-alicante-and-barcelona-city-subcohorts
#8
MULTICENTER STUDY
Ana Cayuela-Mateo, José Miguel Martínez-Martínez, Laia Ferrer Serret, Emily Felt, Jordi Casabona I Barbarà, Francisco Collazos Sanchez, Elena Ronda-Pérez
This study is a part of the multi-centre project "Platform of Longitudinal Studies of Immigrant Families (PELFI)" of the Immigration and Health Subprogram of the CIBER-ESP. It describes the field work and data collection of two sub-cohorts of immigrant and native families, and their main socio-demographic characteristics. Prospective observational cohort study in carried out in Barcelona and Alicante, Spain. The study population is a a non-probabilistic sample of 180 families of Colombian, Ecuadorian and Moroccan origin and 50 families of Spanish origin...
February 9, 2017: Revista Española de Salud Pública
https://www.readbyqxmd.com/read/27481905/ability-of-a-urine-assay-of-type-ii-collagen-cleavage-by-collagenases-to-detect-early-onset-and-progression-of-articular-cartilage-degeneration-results-from-a-population-based-cohort-study
#9
A Robin Poole, Nhuan Ha, Suzanne Bourdon, Eric C Sayre, Ali Guermazi, Jolanda Cibere
OBJECTIVE: To evaluate the association of a sandwich assay for cartilage collagenase-mediated degradation, the C2C human urine sandwich assay (IB-C2C-HUSA), with early and late knee cartilage pathology and with progression of cartilage damage. METHODS: A population-based cohort with knee pain, age 40-79 years, was evaluated at baseline (n = 253) and after mean 3.3 years (n = 161). We evaluated the IB-C2C-HUSA and a related competitive inhibition assay (C2C). The C2C assay was applied to serum (sC2C) and urine (uC2C)...
October 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27474488/-zika-virus-infection-a-new-public-health-emergency-with-great-media-impact
#10
Joan A Caylà, Ángela Domínguez, Elena Rodríguez Valín, Fernando de Ory, Ana Vázquez, Claudia Fortuny
Infection with Zika virus (ZV) has become a new epidemic, with great impact on the media, and is having a strong effect in Latin American countries. Its possible association with microcephaly and Guillain-Barré syndrome prompted the World Health Organization (WHO) to declare on 1 February 2016 that this epidemic is a public health emergency of international concern. Epidemiological data show an increasing incidence in countries like Brazil and Colombia, and that the epidemic is still expanding in many other countries...
November 2016: Gaceta Sanitaria
https://www.readbyqxmd.com/read/27196650/population-survey-features-and-response-rates-a-randomized-experiment
#11
RANDOMIZED CONTROLLED TRIAL
Yimeng Guo, Jacek A Kopec, Jolanda Cibere, Linda C Li, Charles H Goldsmith
OBJECTIVES: To study the effects of several survey features on response rates in a general population health survey. METHODS: In 2012 and 2013, 8000 households in British Columbia, Canada, were randomly allocated to 1 of 7 survey variants, each containing a different combination of survey features. Features compared included administration modes (paper vs online), prepaid incentive ($2 coin vs none), lottery incentive (instant vs end-of-study), questionnaire length (10 minutes vs 30 minutes), and sampling frame (InfoCanada vs Canada Post)...
August 2016: American Journal of Public Health
https://www.readbyqxmd.com/read/26433895/the-validity-of-a-non-radiologist-reader-in-identifying-cam-and-pincer-femoroacetabular-impingement-fai-using-plain-radiography
#12
COMPARATIVE STUDY
C Ratzlaff, C Zhang, J Korzan, L Josey, H Wong, J Cibere, H M Prlic, J A Kopec, J M Esdaile, L C Li, M Barber, B B Forster
The purpose of this study was to evaluate the validity and reliability of a radiographic diagnosis of femoroacetabular impingement (FAI) by a non-radiologist. Symptomatic FAI is prevalent and thought to be a cause of hip osteoarthritis. However, the diagnosis is often delayed by 1-2 years, in large part because radiographic findings are often subtle and clinicians have been unaware of their significance. The purpose of this study was to evaluate the validity of a radiographic diagnosis of FAI by a non-radiologist...
March 2016: Rheumatology International
https://www.readbyqxmd.com/read/26404162/-gender-inequalities-in-research-in-public-health-and-epidemiology-in-spain-2007-2014
#13
COMPARATIVE STUDY
María Del Mar García-Calvente, María Teresa Ruiz-Cantero, María Del Río-Lozano, Carme Borrell, M Pilar López-Sancho
OBJECTIVE: To analyse gender inequalities in research on public health and epidemiology in Spain for the period 2007-2014. METHOD: A descriptive study was conducted by sex of leadership positions in the Centre for Biomedical Research Network (CIBER), especially in the subject area of epidemiology and public health (CIBERESP) in 2014; scientific societies of public health (SESPAS) and epidemiology (SEE) 2009-2014; research projects requested (13,320) and financed (4,699), and monetary amounts of calls for Strategic Action in Health (AES), 2007-2013...
November 2015: Gaceta Sanitaria
https://www.readbyqxmd.com/read/26359653/association-of-body-mass-index-with-incidence-and-progression-of-knee-effusion-on-magnetic-resonance-imaging-and-on-knee-examination
#14
Amy Hung, Eric C Sayre, Ali Guermazi, John M Esdaile, Jacek A Kopec, Anona Thorne, Joel Singer, Hubert Wong, Savvas Nicolaou, Jolanda Cibere
OBJECTIVE: To determine the association of body mass index (BMI) with incidence and progression of knee effusion on magnetic resonance imaging (MRI) and physical examination (PE) in a longitudinal cohort with knee pain. METHODS: A population-based cohort was assessed at baseline and 3 years (n = 163). BMI was categorized as normal (<25), overweight (25-29.9), and obese (≥30). Knee effusion was graded as 0-3 (absent/mild/moderate/severe) on MRI and 0-1 (absent/present) on PE...
April 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/25614375/biological-marker-analysis-as-part-of-the-ciberes-rtic-cancer-separ-strategic-project-on-lung-cancer
#15
Eduard Monsó, Luis M Montuenga, Julio Sánchez de Cos, Cristina Villena
The aim of the Clinical and Molecular Staging of Stage I-IIp Lung Cancer Project is to identify molecular variables that improve the prognostic and predictive accuracy of TMN classification in stage I/IIp non-small cell lung cancer (NSCLC). Clinical data and lung tissue, tumor and blood samples will be collected from 3 patient cohorts created for this purpose. The prognostic protein signature will be validated from these samples, and micro-RNA, ALK, Ros1, Pdl-1, and TKT, TKTL1 y G6PD expression will be analyzed...
September 2015: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/25538769/risk-of-type-2-diabetes-among-osteoarthritis-patients-in-a-prospective-longitudinal-study
#16
M Mushfiqur Rahman, Jolanda Cibere, Aslam H Anis, Charlie H Goldsmith, Jacek A Kopec
Objectives. Our aim was to determine the risk of diabetes among osteoarthritis (OA) cases in a prospective longitudinal study. Methods. Administrative health records of 577,601 randomly selected individuals from British Columbia, Canada, from 1991 to 2009, were analyzed. OA and diabetes cases were identified by checking physician's visits and hospital records. From 1991 to 1996 we documented 19,143 existing OA cases and selected one non-OA individual matched by age, sex, and year of administrative records. Poisson regression and Cox proportional hazards models were fitted to estimate the effects after adjusting for available sociodemographic and medical factors...
2014: International Journal of Rheumatology
https://www.readbyqxmd.com/read/24803668/a-web-based-interactive-framework-to-assist-in-the-prioritization-of-disease-candidate-genes-in-whole-exome-sequencing-studies
#17
Alejandro Alemán, Francisco Garcia-Garcia, Francisco Salavert, Ignacio Medina, Joaquín Dopazo
Whole-exome sequencing has become a fundamental tool for the discovery of disease-related genes of familial diseases and the identification of somatic driver variants in cancer. However, finding the causal mutation among the enormous background of individual variability in a small number of samples is still a big challenge. Here we describe a web-based tool, BiERapp, which efficiently helps in the identification of causative variants in family and sporadic genetic diseases. The program reads lists of predicted variants (nucleotide substitutions and indels) in affected individuals or tumor samples and controls...
July 2014: Nucleic Acids Research
https://www.readbyqxmd.com/read/24775476/cooperative-cardiovascular-disease-research-network-recava
#18
David García-Dorado, Alfonso Castro-Beiras, Javier Díez, Rafael Gabriel, Juan R Gimeno-Blanes, Manuel Ortiz de Landázuri, Pedro L Sánchez, Francisco Fernández-Avilés
Today, cardiovascular disease is the principal cause of death and hospitalization in Spain, and accounts for an annual healthcare budget of more than 4000 million euros. Consequently, early diagnosis, effective prevention, and the optimum treatment of cardiovascular disease present a significant social and healthcare challenge for the country. In this context, combining all available resources to increase the efficacy and healthcare benefits of scientific research is a priority. This rationale prompted the establishment of the Spanish Cooperative Cardiovascular Disease Research Network, or RECAVA (Red Temática de Investigación Cooperativa en Enfermedades Cardiovasculares), 5 years ago...
2008: Revista Española de Cardiología
https://www.readbyqxmd.com/read/24737915/osteoarthritis-incidence-and-trends-in-administrative-health-records-from-british-columbia-canada
#19
M Mushfiqur Rahman, Jolanda Cibere, Charlie H Goldsmith, Aslam H Anis, Jacek A Kopec
OBJECTIVE: To calculate the incidence rates of osteoarthritis (OA) and to describe the changes in incidence using 18 years of administrative health records. METHODS: We analyzed visits to health professionals and hospital admission records in a random sample (n = 640,000) from British Columbia, Canada, from 1991/1992 through 2008/2009. OA was defined in 2 ways: (1) at least 1 physician diagnosis or 1 hospital admission; and (2) at least 2 physician diagnoses in 2 years or 1 hospital admission...
June 2014: Journal of Rheumatology
https://www.readbyqxmd.com/read/24703753/a-novel-non-rapid-eye-movement-and-rapid-eye-movement-parasomnia-with-sleep-breathing-disorder-associated-with-antibodies-to-iglon5-a-case-series-characterisation-of-the-antigen-and-post-mortem-study
#20
Lidia Sabater, Carles Gaig, Ellen Gelpi, Luis Bataller, Jan Lewerenz, Estefanía Torres-Vega, Angeles Contreras, Bruno Giometto, Yaroslau Compta, Cristina Embid, Isabel Vilaseca, Alex Iranzo, Joan Santamaría, Josep Dalmau, Francesc Graus
BACKGROUND: Autoimmunity might be associated with or implicated in sleep and neurodegenerative disorders. We aimed to describe the features of a novel neurological syndrome associated with prominent sleep dysfunction and antibodies to a neuronal antigen. METHODS: In this observational study, we used clinical and video polysomnography to identify a novel sleep disorder in three patients referred to the Sleep Unit of Hospital Clinic, University of Barcelona, Spain, for abnormal sleep behaviours and obstructive sleep apnoea...
June 2014: Lancet Neurology
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