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Camelia Savulescu, Pavla Krizova, Agnes Lepoutre, Jolita Mereckiene, Didrik F Vestrheim, Pilar Ciruela, Maria Ordobas, Marcela Guevara, Eisin McDonald, Eva Morfeldt, Jana Kozakova, Emmanuelle Varon, Suzanne Cotter, Brita A Winje, Carmen Munoz-Almagro, Luis Garcia, Jesus Castilla, Andrew Smith, Birgitta Henriques-Normark, Lucia Pastore Celentano, Germaine Hanquet
BACKGROUND: The Streptococcus pneumoniae Invasive Disease network (SpIDnet) actively monitors populations in nine sites in seven European countries for invasive pneumococcal disease. Five sites use 13-valent pneumococcal conjugate vaccine (PCV13) alone and four use the ten-valent PCV (PCV10) and PCV13. Vaccination uptake is greater than 90% in six sites and 67-78% in three sites. We measured the effects of introducing high-valency PCVs on the incidence of invasive pneumococcal disease in children younger than 5 years...
March 27, 2017: Lancet Respiratory Medicine
J A Kopec, J Cibere, L C Li, C Zhang, M Barber, H Qian, H Wong, G Steininger, H Prlic, J Simatovic, C Ratzlaff, E C Sayre, J Ye, B B Forster, J M Esdaile
OBJECTIVES: The purpose of the study was to determine if physical activity (PA) is a risk factor for persistent or recurrent hip pain in young and middle-aged persons with and without radiographic findings of cam or pincer morphology (CPM). METHODS: A population sample of persons aged 20-49 with (cases) and without (controls) hip pain in Metro Vancouver, Canada, was selected through random digit dialing (RDD). Self-reported PA was expressed as average energy expenditure (MET-hours) per year, over lifetime...
February 20, 2017: Osteoarthritis and Cartilage
Ana Cayuela-Mateo, José Miguel Martínez-Martínez, Laia Ferrer Serret, Emily Felt, Jordi Casabona I Barbarà, Francisco Collazos Sanchez, Elena Ronda-Pérez
This study is a part of the multi-centre project "Platform of Longitudinal Studies of Immigrant Families (PELFI)" of the Immigration and Health Subprogram of the CIBER-ESP. It describes the field work and data collection of two sub-cohorts of immigrant and native families, and their main socio-demographic characteristics. Prospective observational cohort study in carried out in Barcelona and Alicante, Spain. The study population is a a non-probabilistic sample of 180 families of Colombian, Ecuadorian and Moroccan origin and 50 families of Spanish origin...
February 9, 2017: Revista Española de Salud Pública
A Robin Poole, Nhuan Ha, Suzanne Bourdon, Eric C Sayre, Ali Guermazi, Jolanda Cibere
OBJECTIVE: To evaluate the association of a sandwich assay for cartilage collagenase-mediated degradation, the C2C human urine sandwich assay (IB-C2C-HUSA), with early and late knee cartilage pathology and with progression of cartilage damage. METHODS: A population-based cohort with knee pain, age 40-79 years, was evaluated at baseline (n = 253) and after mean 3.3 years (n = 161). We evaluated the IB-C2C-HUSA and a related competitive inhibition assay (C2C). The C2C assay was applied to serum (sC2C) and urine (uC2C)...
October 2016: Journal of Rheumatology
Joan A Caylà, Ángela Domínguez, Elena Rodríguez Valín, Fernando de Ory, Ana Vázquez, Claudia Fortuny
Infection with Zika virus (ZV) has become a new epidemic, with great impact on the media, and is having a strong effect in Latin American countries. Its possible association with microcephaly and Guillain-Barré syndrome prompted the World Health Organization (WHO) to declare on 1 February 2016 that this epidemic is a public health emergency of international concern. Epidemiological data show an increasing incidence in countries like Brazil and Colombia, and that the epidemic is still expanding in many other countries...
November 2016: Gaceta Sanitaria
Yimeng Guo, Jacek A Kopec, Jolanda Cibere, Linda C Li, Charles H Goldsmith
OBJECTIVES: To study the effects of several survey features on response rates in a general population health survey. METHODS: In 2012 and 2013, 8000 households in British Columbia, Canada, were randomly allocated to 1 of 7 survey variants, each containing a different combination of survey features. Features compared included administration modes (paper vs online), prepaid incentive ($2 coin vs none), lottery incentive (instant vs end-of-study), questionnaire length (10 minutes vs 30 minutes), and sampling frame (InfoCanada vs Canada Post)...
August 2016: American Journal of Public Health
C Ratzlaff, C Zhang, J Korzan, L Josey, H Wong, J Cibere, H M Prlic, J A Kopec, J M Esdaile, L C Li, M Barber, B B Forster
The purpose of this study was to evaluate the validity and reliability of a radiographic diagnosis of femoroacetabular impingement (FAI) by a non-radiologist. Symptomatic FAI is prevalent and thought to be a cause of hip osteoarthritis. However, the diagnosis is often delayed by 1-2 years, in large part because radiographic findings are often subtle and clinicians have been unaware of their significance. The purpose of this study was to evaluate the validity of a radiographic diagnosis of FAI by a non-radiologist...
March 2016: Rheumatology International
María Del Mar García-Calvente, María Teresa Ruiz-Cantero, María Del Río-Lozano, Carme Borrell, M Pilar López-Sancho
OBJECTIVE: To analyse gender inequalities in research on public health and epidemiology in Spain for the period 2007-2014. METHOD: A descriptive study was conducted by sex of leadership positions in the Centre for Biomedical Research Network (CIBER), especially in the subject area of epidemiology and public health (CIBERESP) in 2014; scientific societies of public health (SESPAS) and epidemiology (SEE) 2009-2014; research projects requested (13,320) and financed (4,699), and monetary amounts of calls for Strategic Action in Health (AES), 2007-2013...
November 2015: Gaceta Sanitaria
Amy Hung, Eric C Sayre, Ali Guermazi, John M Esdaile, Jacek A Kopec, Anona Thorne, Joel Singer, Hubert Wong, Savvas Nicolaou, Jolanda Cibere
OBJECTIVE: To determine the association of body mass index (BMI) with incidence and progression of knee effusion on magnetic resonance imaging (MRI) and physical examination (PE) in a longitudinal cohort with knee pain. METHODS: A population-based cohort was assessed at baseline and 3 years (n = 163). BMI was categorized as normal (<25), overweight (25-29.9), and obese (≥30). Knee effusion was graded as 0-3 (absent/mild/moderate/severe) on MRI and 0-1 (absent/present) on PE...
April 2016: Arthritis Care & Research
Eduard Monsó, Luis M Montuenga, Julio Sánchez de Cos, Cristina Villena
The aim of the Clinical and Molecular Staging of Stage I-IIp Lung Cancer Project is to identify molecular variables that improve the prognostic and predictive accuracy of TMN classification in stage I/IIp non-small cell lung cancer (NSCLC). Clinical data and lung tissue, tumor and blood samples will be collected from 3 patient cohorts created for this purpose. The prognostic protein signature will be validated from these samples, and micro-RNA, ALK, Ros1, Pdl-1, and TKT, TKTL1 y G6PD expression will be analyzed...
September 2015: Archivos de Bronconeumología
M Mushfiqur Rahman, Jolanda Cibere, Aslam H Anis, Charlie H Goldsmith, Jacek A Kopec
Objectives. Our aim was to determine the risk of diabetes among osteoarthritis (OA) cases in a prospective longitudinal study. Methods. Administrative health records of 577,601 randomly selected individuals from British Columbia, Canada, from 1991 to 2009, were analyzed. OA and diabetes cases were identified by checking physician's visits and hospital records. From 1991 to 1996 we documented 19,143 existing OA cases and selected one non-OA individual matched by age, sex, and year of administrative records. Poisson regression and Cox proportional hazards models were fitted to estimate the effects after adjusting for available sociodemographic and medical factors...
2014: International Journal of Rheumatology
Alejandro Alemán, Francisco Garcia-Garcia, Francisco Salavert, Ignacio Medina, Joaquín Dopazo
Whole-exome sequencing has become a fundamental tool for the discovery of disease-related genes of familial diseases and the identification of somatic driver variants in cancer. However, finding the causal mutation among the enormous background of individual variability in a small number of samples is still a big challenge. Here we describe a web-based tool, BiERapp, which efficiently helps in the identification of causative variants in family and sporadic genetic diseases. The program reads lists of predicted variants (nucleotide substitutions and indels) in affected individuals or tumor samples and controls...
July 2014: Nucleic Acids Research
David García-Dorado, Alfonso Castro-Beiras, Javier Díez, Rafael Gabriel, Juan R Gimeno-Blanes, Manuel Ortiz de Landázuri, Pedro L Sánchez, Francisco Fernández-Avilés
Today, cardiovascular disease is the principal cause of death and hospitalization in Spain, and accounts for an annual healthcare budget of more than 4000 million euros. Consequently, early diagnosis, effective prevention, and the optimum treatment of cardiovascular disease present a significant social and healthcare challenge for the country. In this context, combining all available resources to increase the efficacy and healthcare benefits of scientific research is a priority. This rationale prompted the establishment of the Spanish Cooperative Cardiovascular Disease Research Network, or RECAVA (Red Temática de Investigación Cooperativa en Enfermedades Cardiovasculares), 5 years ago...
2008: Revista Española de Cardiología
M Mushfiqur Rahman, Jolanda Cibere, Charlie H Goldsmith, Aslam H Anis, Jacek A Kopec
OBJECTIVE: To calculate the incidence rates of osteoarthritis (OA) and to describe the changes in incidence using 18 years of administrative health records. METHODS: We analyzed visits to health professionals and hospital admission records in a random sample (n = 640,000) from British Columbia, Canada, from 1991/1992 through 2008/2009. OA was defined in 2 ways: (1) at least 1 physician diagnosis or 1 hospital admission; and (2) at least 2 physician diagnoses in 2 years or 1 hospital admission...
June 2014: Journal of Rheumatology
Lidia Sabater, Carles Gaig, Ellen Gelpi, Luis Bataller, Jan Lewerenz, Estefanía Torres-Vega, Angeles Contreras, Bruno Giometto, Yaroslau Compta, Cristina Embid, Isabel Vilaseca, Alex Iranzo, Joan Santamaría, Josep Dalmau, Francesc Graus
BACKGROUND: Autoimmunity might be associated with or implicated in sleep and neurodegenerative disorders. We aimed to describe the features of a novel neurological syndrome associated with prominent sleep dysfunction and antibodies to a neuronal antigen. METHODS: In this observational study, we used clinical and video polysomnography to identify a novel sleep disorder in three patients referred to the Sleep Unit of Hospital Clinic, University of Barcelona, Spain, for abnormal sleep behaviours and obstructive sleep apnoea...
June 2014: Lancet Neurology
Lluís Serra-Majem, Pilar Riobó Serván, Susana Belmonte Cortés, Arturo Anadón Navarro, Javier Aranceta Bartrina, Eladia Franco Vargas, Reina García-Closas, Carmen Gómez-Candela, Elvira Herrero Sancho, Carlo La Vecchia, M Luisa López Díaz-Ufano, Gregorio Varela-Moreiras, Jesús Vázquez Castro, Lourdes Ribas-Barba, Francisca Alcaraz-Cebrián, Pedro Pablo García-Luna, Mercedes González-Gomis, Marcela González-Gross, Susana Granado de la Orden, Ana María López-Sobaler, José Manuel Moreno Villares, Rosa María Ortega Anta, Carmen Pérez-Rodrigo, Isabel Polanco Allué, Rafael Urrialde de Andrés
Multidisciplinary experts in the areas of nutrition and health met in Chinchón, Madrid, on November 25-26, 2013 under the auspices of the Fundación para la Investigación Nutricional (Nutrition Research Foundation) and with the collaboration of the Madrid Regional Government's Health Ministry, the International Sweeteners Association and the Carlos III Health Institute CIBER of Physiopathology of Obesity and Nutrition. They analyzed the current status of scientific knowledge on low- and no-calorie sweeteners (LNCS) and developed a consensus Decalogue on their use; this constitutes the Chinchón Declaration...
2014: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
M D Crema, J Cibere, E C Sayre, F W Roemer, H Wong, A Thorne, J Singer, J M Esdaile, M D Marra, J A Kopec, S Nicolaou, A Guermazi
PURPOSE: To assess the association between subchondral sclerosis detected at baseline with MRI and cartilage loss over time in the same region of the knee in a cohort of subjects with knee pain. METHODS: 163 subjects with knee pain participated in a longitudinal study to assess knee osteoarthritis progression (KOAP). Subjects received baseline knee radiographs as well as baseline and 3-year follow-up MRI examinations. Baseline subchondral sclerosis and bone marrow lesions (BMLs) were scored semiquantitatively on MRI in each region from 0 to 3...
April 2014: Osteoarthritis and Cartilage
Carlo A Marra, Maja Grubisic, Jolanda Cibere, Kelly A Grindrod, John C Woolcott, Louise Gastonguay, John M Esdaile
OBJECTIVE: To determine if a pharmacist-initiated multidisciplinary strategy provides value for money compared to usual care in participants with previously undiagnosed knee osteoarthritis. METHODS: Pharmacies were randomly allocated to provide either 1) usual care and a pamphlet or 2) intervention care, which consisted of education, pain medication management by a pharmacist, physiotherapy-guided exercise, and communication with the primary care physician. Costs and quality-adjusted life-years (QALYs) were determined for patients assigned to each treatment and incremental cost-effectiveness ratios (ICERs) were determined...
June 2014: Arthritis Care & Research
Jacob L Jaremko, Robert G W Lambert, Veronika Zubler, Ulrich Weber, Damien Loeuille, Frank W Roemer, Jolanda Cibere, Marcus Pianta, David Gracey, Philip Conaghan, Mikkel Ostergaard, Walter P Maksymowych
OBJECTIVE: As a wider variety of therapeutic options for osteoarthritis (OA) becomes available, there is an increasing need to objectively evaluate disease severity on magnetic resonance imaging (MRI). This is more technically challenging at the hip than at the knee, and as a result, few systematic scoring systems exist. The OMERACT (Outcome Measures in Rheumatology) filter of truth, discrimination, and feasibility can be used to validate image-based scoring systems. Our objective was (1) to review the imaging features relevant to the assessment of severity and progression of hip OA; and (2) to review currently used methods to grade these features in existing hip OA scoring systems...
February 2014: Journal of Rheumatology
Walter P Maksymowych, Jolanda Cibere, Damien Loeuille, Ulrich Weber, Veronika Zubler, Frank W Roemer, Jacob L Jaremko, Eric C Sayre, Robert G W Lambert
OBJECTIVE: Development of a validated magnetic resonance image (MRI) scoring system is essential in hip OA because radiographs are insensitive to change. We assessed the feasibility and reliability of 2 previously developed scoring methods: (1) the Hip Inflammation MRI Scoring System (HIMRISS) and (2) the Hip Osteoarthritis MRI Scoring System (HOAMS). METHODS: Six readers (3 radiologists, 3 rheumatologists) participated in 2 reading exercises. In Reading Exercise 1, MRI of the hip of 20 subjects were read at a single time point followed by further standardization of methodology...
February 2014: Journal of Rheumatology
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