keyword
https://read.qxmd.com/read/37755751/lutein-modulates-oxidative-stress-inflammatory-and-apoptotic-biomarkers-related-to-di-2-ethylhexyl-phthalate-dehp-hepato-nephrotoxicity-in-male-rats-role-of-nuclear-factor-kappa-b
#21
JOURNAL ARTICLE
Dina R S Gad El-Karim, Mohamed A Lebda, Badriyah S Alotaibi, Attalla F El-Kott, Heba I Ghamry, Mustafa Shukry
Phthalates are widely distributed in our environment due to their usage in many industries, especially in plastic production, which has become an essential part of daily life. This investigation aimed to assess the potential remedial influence of lutein, a naturally occurring carotenoid, on phthalate-triggered damage to the liver and kidneys. When di-(2-ethylhexyl) phthalate (DEHP) was administered to male albino rats over sixty straight days at a dosage of 200 mg/kg body weight, it resulted in a significant increase in the serum activity of liver enzymes (AST, ALT, and GGT), alpha-fetoprotein, creatinine, and cystatin-C, as well as disruptions in the serum protein profile...
August 30, 2023: Toxics
https://read.qxmd.com/read/37698614/quantitative-ultrasound-fatty-liver-evaluation-in-a-pediatric-population-comparison-with-magnetic-resonance-imaging-of-liver-proton-density-fat-fraction
#22
JOURNAL ARTICLE
Giorgia Polti, Francesco Frigerio, Giovanni Del Gaudio, Patrizia Pacini, Vincenzo Dolcetti, Maurizio Renda, Sergio Angeletti, Michele Di Martino, Giovanni Iannetti, Francesco Massimo Perla, Eleonora Poggiogalle, Vito Cantisani
BACKGROUND: Biopsy remains the gold standard for the diagnosis of hepatic steatosis, the leading cause of pediatric chronic liver disease; however, its costs call for less invasive methods. OBJECTIVE: This study examined the diagnostic accuracy and reliability of quantitative ultrasound (QUS) for the assessment of liver fat content in a pediatric population, using magnetic resonance imaging proton density fat fraction (MRI-PDFF) as the reference standard. MATERIALS AND METHODS: We enrolled 36 patients...
September 12, 2023: Pediatric Radiology
https://read.qxmd.com/read/37689561/fluid-resuscitation-in-the-early-management-of-acute-pancreatitis-evidence-from-a-systematic-review-and-meta-analysis
#23
REVIEW
Abby Dawson, Monish Karunakaran, Zubin D Sharma, Shahid Ullah, Savio G Barreto
BACKGROUND: Third space fluid loss is one of the hallmarks of the pathophysiology of acute pancreatitis (AP) contributing to complications, including organ failure and death. We conducted a systematic review of literature to determine the ideal fluid resuscitation in the early management of AP, primarily comparing aggressive versus moderate intravenous fluid resuscitation (AIR vs MIR). METHODS: A systematic review of major reference databases was undertaken. Meta-analysis was performed using random-effects model...
December 2023: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://read.qxmd.com/read/37666595/toxicological-hepato-renal-endocrine-disruption-oxidative-stress-and-immunohistopathological-responses-of-chitosan-capped-gold-nanocomposite-on-biomphalaria-alexandrina-snails
#24
JOURNAL ARTICLE
Amina M Ibrahim, Mohamad Bekhit, Rehab Sokary, Olfat Hammam, Shimaa Atta
The present investigation aimed to synthesize chitosan‑gold nanocomposites (Ch-AuNPs) with gamma radiation, then to evaluate its toxic effect on the freshwater snails Biomphalaia alexandrina. Results showed that Ch-AuNPs is spherical shaped with average size 12 nm. It had a toxic effect against B. alexandrina snails with LC50 20.43 mg/l. Exposure of B. alexandrina snails to LC10 7.51 or LC25 13.63 mg/l of Ch-AuNPs, reduced the survival, reproductive and fecundity rates; total protein and albumin; both testosterone (T) and 17β Estradiol (E) levels; SOD and CAT activities of exposed snails while increased the activities of transaminases (AST & ALT), uric acid, creatinine, TAC and MDA levels compared to the control group...
September 2023: Pesticide Biochemistry and Physiology
https://read.qxmd.com/read/37663806/protective-impacts-of-withania-somnifera-leaf-extract-from-taif-area-against-diclofenac-induced-hepato-renal-toxicity-role-of-antioxidants-inflammation-apoptosis-and-anti-oxidative-stress-biomarkers
#25
JOURNAL ARTICLE
Mohamed Mohamed Soliman, Ahmed M Elshehawei, Saed Althobaiti, Samy M Sayed
Current study examined the boosting impacts of Withania somnifera leaf extract from Taif area (high-altitude area) against hepatic and renal toxicity induced by diclofenac in experimental rats. Withania is highly grown on Taif area as environmental herb with multiple functions. Diclofenac is non-steroidal medication used for treatment of pain but over dose has severe side effects. Thirty-two adult Wistar rats of male type were subdivided into 4 groups. The control rats (group 1) received saline. Second group received diclofenac (50 mg/kg BW intraperitoneally) at days 4 and 5...
August 2023: Toxicology Research
https://read.qxmd.com/read/37662722/chitosan-neem-nanocapsule-enhances-immunity-and-disease-resistance-in-nile-tilapia-oreochromis-niloticus
#26
JOURNAL ARTICLE
Rowida E Ibrahim, Gehad E Elshopakey, Abdelwahab A Abdelwarith, Elsayed M Younis, Sameh H Ismail, Amany I Ahmed, Mahmoud M El-Saber, Ahmed E Abdelhamid, Simon J Davies, Abdelhakeem El-Murr, Afaf N Abdel Rahman
Finding eco-friendly alternatives for antibiotics in treating bacterial diseases affecting the aquaculture sector is essential. Herbal plants are promising alternatives, especially when combined with nanomaterials. Neem ( Azadirachta indica ) leaves extract was synthesized using a chitosan nanocapsule. Chitosan neem nanocapsule (CNNC) was tested in- vitro and in- vivo against the Aeromonas sobria ( A. sobria ) challenge in Nile tilapia. A preliminary experiment with 120 Nile tilapia was conducted to determine the therapeutic dose of CNNC, which was established to be 1 mg/L...
September 2023: Heliyon
https://read.qxmd.com/read/37662710/intraperitoneal-hepato-renal-toxicity-of-zinc-oxide-and-nickel-oxide-nanoparticles-in-male-rats-biochemical-hematological-and-histopathological-studies
#27
JOURNAL ARTICLE
Noura S Abouzeinab, Nour Kahil, Najla Fakhruddin, Ramadan Awad, Mahmoud I Khalil
In recent years, zinc oxide (ZnO) and nickel oxide (NiO) nanoparticles (NPs) have become more prevalent in commercial and industrial products. However, questions have been raised regarding their potential harm to human health. Limited studies have been conducted on their intraperitoneal toxicity in rats, and their co-exposure effects remain uncertain. Therefore, this study aimed to investigate some biological responses induced by a single intraperitoneal injection of ZnO-NPs (200 mg/kg) and/or NiO-NPs (50 mg/kg) in rats over time intervals...
2023: EXCLI Journal
https://read.qxmd.com/read/37659903/extended-criteria-liver-donation-after-circulatory-death-with-prolonged-warm-ischemia-a-pilot-experience-of-normothermic-regional-perfusion-and-no-subsequent-ex-situ-machine-perfusion
#28
JOURNAL ARTICLE
Stefania Camagni, Annalisa Amaduzzi, Lorenzo Grazioli, Davide Ghitti, Luisa Pasulo, Domenico Pinelli, Stefano Fagiuoli, Michele Colledan
BACKGROUND: Livers from controlled donation after circulatory death (cDCD) with very prolonged warm ischemic time (WIT) are regularly transplanted after abdominal normothermic regional perfusion (aNRP) plus ex-situ machine perfusion (MP). Considering aNRP as in-situ MP, we investigated whether the results of a pilot experience of extended criteria cDCD liver transplantation (LT) with prolonged WIT, with aNRP alone, were comparable to the best possible outcomes in low-risk cDCD LT. METHODS: Prospectively collected data on 24 cDCD LT, with aNRP alone, were analyzed...
July 26, 2023: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://read.qxmd.com/read/37643325/the-ratio-of-mir-122-to-mir-20a-mir-122-mir-20a-is-a-useful-minimally-invasive-biomarker-for-non-alcoholic-fatty-liver-disease-detection
#29
JOURNAL ARTICLE
Yuji Hattori, Hiroya Yamada, Eiji Munetsuna, Ryosuke Fujii, Yoshitaka Ando, Mirai Yamazaki, Genki Mizuno, Yoshiki Tsuboi, Yuya Ishihara, Naohiro Ichino, Keiko Sugimoto, Keisuke Osakabe, Hiroaki Ishikawa, Koji Ohashi, Koji Suzuki
Background: The increasing prevalence of non-alcoholic fatty liver disease (NAFLD) has become a global health problem. NAFLD has few initial symptoms and may be difficult to detect early, so there is need for a minimally invasive early detection marker. We hypothesized that miR-122 and miR-20a levels combined, as the miR-122/miR-20a ratio might detect NAFLD more sensitively. Methods: This study involved 167 participants with low alcohol intake. Those who had an increase in echogenicity of the liver parenchyma and hepato-renal contrast on ultrasonography were classified as the NAFLD group ( n  = 44), which was further classified into mild ( n  = 26) and severe ( n  = 18) groups based on echogenic intensity and hepatic vessel and diaphragm visualization...
August 2023: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/37635794/fetal-renal-cystic-disease-and-post-natal-follow-up-a-single-center-experience
#30
JOURNAL ARTICLE
Lorena Botero-Calderon, Anne Lawrence, Natalie O'Toole, Lisa M Guay-Woodford
INTRODUCTION: Prenatal sonographic evidence of large, echogenic, or cystic kidneys may indicate any one of a diverse set of disorders including renal ciliopathies, congenital anomalies of the kidney and urinary tract (CAKUT), or multisystem syndromic disorders. Systematic transition planning for these infants from in utero detection to post-natal nephrology management remains to be established. AIM OF THE WORK: We sought to evaluate the presentation and transition planning for infants identified in utero with bilateral renal cystic disease...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/37624969/a-prospective-study-on-the-endometrium-properties-and-the-pregnancy-rate-of-infertile-women-with-thin-endometrium-receiving-fructus-ligustri-lucidi-used-in-traditional-chinese-medicine
#31
JOURNAL ARTICLE
Xiangyan Ruan, Zhongting Xu, Xin Xu, Yu Yang, Jiaojiao Cheng, Suiyu Luo, Min Min, Meng Li, Luping Zhang, Rui Ju, Fengyu Jin, Alfred Otto Mueck
OBJECTIVE: To evaluate whether Zi Gui Nv Zhen capsules (ZGNZC) can increase the fertility rate of Chinese women with infertility due to thin endometrium. METHODS: Prospective, randomized, open-labeled 3-monthly study; 104 patients (aged 20-40 years) receiving either ZGNZC (experimental group, n  = 55) or not (control group, n  = 49). Main outcomes: thickness/type of the endometrium during ovulation and pregnancy rate. Between-group analysis (A) compares the experimental vs...
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37623096/alleviating-effect-of-a-magnetite-fe-3-o-4-nanogel-against-waterborne-lead-induced-physiological-disturbances-histopathological-changes-and-lead-bioaccumulation-in-african-catfish
#32
JOURNAL ARTICLE
Afaf N Abdel Rahman, Basma Ahmed Elkhadrawy, Abdallah Tageldein Mansour, Heba M Abdel-Ghany, Engy Mohamed Mohamed Yassin, Asmaa Elsayyad, Khairiah Mubarak Alwutayd, Sameh H Ismail, Heba H Mahboub
Heavy metal toxicity is an important issue owing to its harmful influence on fish. Hence, this study is a pioneer attempt to verify the in vitro and in vivo efficacy of a magnetite (Fe3 O4 ) nanogel (MNG) in mitigating waterborne lead (Pb) toxicity in African catfish. Fish ( n = 160) were assigned into four groups for 45 days. The first (control) and second (MNG) groups were exposed to 0 and 1.2 mg L-1 of MNG in water. The third (Pb) and fourth (MNG + Pb) groups were exposed to 0 and 1.2 mg L-1 of MNG in water and 69...
August 8, 2023: Gels
https://read.qxmd.com/read/37605475/therapeutic-and-phytochemical-properties-of-thymoquinone-derived-from-nigella-sativa
#33
JOURNAL ARTICLE
Gaurav Tiwari, Monisha Gupta, Lalchand D Devhare, Ruchi Tiwari
BACKGROUND: Nigella sativa (N. sativa), commonly known as black seed or black cumin, belongs to the family Ranunculaceae. It contains several phytoconstituents, thymoquinone (TQ), thymol, thymohydroquinone, carvacrol, and dithymoquinone. TQ is the main phytoconstituent present in N. sativa that is used as an herbal compound, and it is widely used as an antihypertensive, liver tonic, diuretic, digestive, anti-diarrheal, appetite stimulant, analgesic, and antibacterial agent, and in skin disorders...
August 11, 2023: Current Drug Research Reviews
https://read.qxmd.com/read/37588571/characterization-dose-dependent-assessment-of-hepatorenal-oxidative-stress-hematological-parameters-and-histopathological-divulging-of-the-hepatic-damages-induced-by-zinc-oxide-nanoparticles-zno-nps-in-adult-male-sprague-dawley-rats
#34
JOURNAL ARTICLE
Sana Kausar, Farhat Jabeen, Muhammad Asif Latif, Muhammad Asad
Nanoparticles are beneficial in many aspects to human life but their excessive use can cause various abnormalities. They dispose in the environment through transport, industrial and agricultural usage and enter in living body through dermal, respiratory route or ingested with the lipsticks and there higher concentration produces toxicity. Therefore, current study characterized ZnO-NPs to evaluate toxic ability by X-rays diffraction (XRD) and Scanning Electron Microscopy (SEM) techniques and showed 29.83 and 35 nm size, respectively with hexagonal crystalline structure...
September 2023: Saudi Journal of Biological Sciences
https://read.qxmd.com/read/37584738/pkhd1-cyli-cyli-mice-have-altered-renal-pkhd1-mrna-processing-and-hormonally-sensitive-liver-disease
#35
JOURNAL ARTICLE
Chaozhe Yang, Naoe Harafuji, Ljubica Caldovic, Weiying Yu, Ravindra Boddu, Surajit Bhattacharya, Hayk Barseghyan, Heather Gordish-Dressman, Oded Foreman, Zsuzsa Bebok, Eva M Eicher, Lisa M Guay-Woodford
Autosomal-recessive polycystic kidney disease (ARPKD; MIM #263200) is a severe, hereditary, hepato-renal fibrocystic disorder that causes early childhood morbidity and mortality. Mutations in the polycystic kidney and hepatic disease 1 (PKHD1) gene, which encodes the protein fibrocystin/polyductin complex (FPC), cause all typical forms of ARPKD. Several mouse lines carrying diverse, genetically engineered disruptions in the orthologous Pkhd1 gene have been generated, but none expresses the classic ARPKD renal phenotype...
August 16, 2023: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/37575631/sociodemographic-and-medical-characteristics-of-liver-cirrhosis-deaths-in-a-ghanaian-tertiary-hospital
#36
JOURNAL ARTICLE
William K Agbozo, Bartholomew Dzudzor, Eric Ny Nyarko, Karen Lartey-Abrahams, Roberta N A Mensah, Kenneth Tachi
OBJECTIVE: Cirrhosis is common in Ghana because of its high risk factors prevalence. However, information on cirrhosis in Ghana is lacking. This study aimed to study the clinical, and laboratory characteristics of cirrhotic patients in a tertiary hospital in Ghana. DESIGN: This was a retrospective study of sociodemographic characteristics, symptoms and signs, biochemical and fibrotic indices, treatments, and complications data of 247 patients with cirrhosis who died on admission...
December 2022: Ghana Medical Journal
https://read.qxmd.com/read/37554975/the-role-of-gastroenterologists-in-preoperative-assessment-and-management-of-prospective-renal-transplantation-candidates
#37
REVIEW
Suprabhat Giri, Kumar Avijeet Dash, Jijo Varghese, Shivaraj Afzalpurkar
UNLABELLED: Renal transplant is the most common organ transplant worldwide, accounting for 65% of the total number of transplants. End-stage renal disease (ESRD) often has multiple significant comorbidities. Among the gastrointestinal (GI) disorders, peptic ulcer disease (PUD), cholelithiasis, and colon and liver diseases increase the risk of posttransplant morbidity. Potential renal transplantation (RT) candidates need a multidisciplinary assessment of coexisting illnesses, which may affect the perioperative risk and survival after transplantation...
2023: Euroasian Journal of Hepato-Gastroenterology
https://read.qxmd.com/read/37512162/sirt1-nrf2-nf-%C3%AE%C2%BAb-signaling-mediates-anti-inflammatory-and-anti-apoptotic-activities-of-oleanolic-acid-in-a-mouse-model-of-acute-hepatorenal-damage
#38
JOURNAL ARTICLE
Manea A I Alqrad, Dina S El-Agamy, Sabrin R M Ibrahim, Alaa Sirwi, Hossam M Abdallah, Essam Abdel-Sattar, Ali M El-Halawany, Wael M Elsaed, Gamal A Mohamed
Background and objectives: Oleanolic acid (OA) is a penta-cyclic triterpene with diverse bioactivities such as anticarcinogenic, antiviral, antimicrobial, hepatoprotective, anti-atherosclerotic, hypolipidemic, and gastroprotective. However, its effects on hepatorenal damage remain unclear. The protective activity of OA, separated from Viscum schimperi (Loranthaceae), against TAA (thioacetamide)-produced acute hepatic and renal damage was explored. Materials and Methods: Mice were treated with OA for 7 days before TAA (200 mg/kg, i...
July 24, 2023: Medicina
https://read.qxmd.com/read/37406490/acute-mancozeb-fungicide-exposure-induces-neuro-ethology-disruption-health-disorders-and-immune-oxidative-dysfunction-in-nile-tilapia-oreochromis-niloticus
#39
JOURNAL ARTICLE
Rowida E Ibrahim, Mohamed A Elbealy, Gamal A Salem, Abdelwahab A Abdelwarith, Elsayed M Younis, Eman Wagih, Ahmed Asaid Elkady, Simon J Davies, Afaf N Abdel Rahman
An acute exposure study of mancozeb (MAZ) fungicide was applied on Oreochromis niloticus for 96-h duration. Three hundred fish (20.50 ± 1.60 g) were assigned into six groups (50 fish/ group; 10 fish/replicate) and exposed to different six concentrations (0, 4, 8, 12, 16, and 20 mg L-1 ) of MAZ for 96-h. The Probit analysis program was used to compute the 96-h lethal concentration 50 (96-h LC50 ) of MAZ. During the exposure duration, the fish's behavior, clinical symptoms, and mortalities were recorded daily...
July 2, 2023: Aquatic Toxicology
https://read.qxmd.com/read/37389233/prospective-study-comparing-hepatic-steatosis-assessment-by-magnetic-resonance-imaging-and-four-ultrasound-methods-in-105-successive-patients
#40
JOURNAL ARTICLE
Remi Collin, Benoit Magnin, Constance Gaillard, Carine Nicolas, Armand Abergel, Benjamin Buchard
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is becoming a major health problem, resulting in hepatic, metabolic and cardio-vascular morbidity. AIM: To evaluate new ultrasonographic tools to detect and measure hepatic steatosis. METHODS: We prospectively included 105 patients referred to our liver unit for NAFLD suspicion or follow-up. They underwent ultrasonographic measurement of liver sound speed estimation (SSE) and attenuation coefficient (AC) using Aixplorer MACH 30 (Supersonic Imagine, France), continuous controlled attenuation parameter (cCAP) using Fibroscan (Echosens, France) and standard liver ultrasound with hepato-renal index (HRI) calculation...
June 14, 2023: World Journal of Gastroenterology: WJG
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