Igor Lopes Dos Santos, Michael Mitchell, Pedro A S Nogueira, M Carmen Lafita-Navarro, Lizbeth Perez-Castro, Joyane Eriom, Jessica A Kilgore, Noelle S Williams, Lei Guo, Lin Xu, Maralice Conacci-Sorrell
Neuroblastoma poses significant challenges in clinical management. Despite its relatively low incidence, this malignancy contributes disproportionately to cancer-related childhood mortality. Tailoring treatments based on risk stratification, including MYCN oncogene amplification, remains crucial, yet high-risk cases often confront therapeutic resistance and relapse. Here, we explore the aryl hydrocarbon receptor (AHR), a versatile transcription factor implicated in diverse physiological functions such as xenobiotic response, immune modulation, and cell growth...
March 3, 2024: FEBS Journal