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Ji-Xia Ren, Huo-Lian Qian, Yu-Xin Huang, Ning-Yu Zhu, Shu-Yi Si, Yong Xie
BACKGROUND: Tuberculosis remains one of the deadliest infectious diseases in humans. It has caused more than 100 million deaths since its discovery in 1882. Currently, more than 5 million people are infected with TB bacterium each year. The cell wall of Mycobacterium tuberculosis plays an important role in maintaining the ability of mycobacteria to survive in a hostile environment. Therefore, we report a virtual screening (VS) study aiming to identify novel inhibitors that simultaneously target RmlB and RmlC, which are two essential enzymes for the synthesis of the cell wall of M...
March 2015: Computers in Biology and Medicine
Adnan M Khan, Hesham El-Daly, Emma Simmons, Nasir M Rajpoot
BACKGROUND: Segmentation of areas containing tumor cells in standard H&E histopathology images of breast (and several other tissues) is a key task for computer-assisted assessment and grading of histopathology slides. Good segmentation of tumor regions is also vital for automated scoring of immunohistochemical stained slides to restrict the scoring or analysis to areas containing tumor cells only and avoid potentially misleading results from analysis of stromal regions. Furthermore, detection of mitotic cells is critical for calculating key measures such as mitotic index; a key criteria for grading several types of cancers including breast cancer...
2013: Journal of Pathology Informatics
Y Levy, Y Gimpel, L Abutbul, E Hochgraf, U Cogan
Platelet lipid composition was determined in subjects with hypercholesterolemia (HC) (9.17 ± 2.15 mmol/L), hypocholesterolemia (HYPOC) (3.29 ± 1.01 mmol/L), and normocholesterolemic controls (NC) (5.29 ± 0.82 mmol/L). Lipid composition was quantitated in washed platelets by measuring platelet cholesterol (C) and phospholipid (PL) content, C/PL molar ratio and platelet PL phosphatidylcholine (PC) to sphingmyelin (SM) ratio. There was a significant increase and a significant decrease in C/PL molar ratio in subjects with HC and HYPOC compared to normals (0...
1994: Platelets
P E Murray, P J Lumley, A J Smith, H F Ross
The purpose of this study was to compare the rate of hydroxyl ion release from commercially available setting and non-setting calcium hydroxide products. The rate of hydroxyl ion release is important, as this has been suggested to be the main factor in the therapeutic activity of these products. In total, hydroxyl ion release was measured from 1104 samples of Dycal, Life, Calasept and Hypocal in solution using in vitro titration. The rate of hydroxyl ion release was measured for up to 14 days, using two sizes of sample surface area...
December 2000: Endodontics & Dental Traumatology
P E Murray, P J Lumley, H F Ross, A J Smith
The purpose of this work was to develop a tooth slice organ culture method to assess the response of the cells of the dental pulp to commonly used dental materials and products. Wistar rat tooth slices were grown in culture for two and ten days in the presence of dental materials. After culture, the tooth tissues were processed and the responses of the pulpal cells were analysed histomorphometrically. Cytotoxic cell destruction was observed following the direct application of test materials to tooth slices (n = 298) after 10 days in culture (MANOVA, P = 0...
August 2000: Biomaterials
C Yesilsoy, L Z Koren, D R Morse, C Kobayashi
Grossman's sealer, eucapercha, Endo-Fill, CRCS, Sealapex, Hypocal, and sterile saline solution (0.3 ml of each) were injected into specific dorsal subdermal tissue sites of 12 guinea pigs. The animals were killed after 6 days, 15 days, and 80 days (four per time period). Analysis of tissue response showed that, overall, Sealapex and Endo-Fill had less severe inflammatory reactions than any of the other test materials. Grossman's sealer, CRCS, and Hypocal showed principally severe inflammatory responses at both 6 and 15 days, but mild reactions at 80 days...
April 1988: Oral Surgery, Oral Medicine, and Oral Pathology
Z Z al-Khatib, R H Baum, D R Morse, C Yesilsoy, S Bhambhani, M L Furst
The antimicrobial activity of an endodontic sealer can be helpful in destroying any remaining root canal microbes. Therefore it was decided to test the antimicrobial activity of several commonly used endodontic sealers. The sealers used were Grossman's sealer, Tubliseal, Calciobiotic, Sealapex, Hypocal, eucapercha, Nogenol, and AH26. Also tested were dry calcium hydroxide powder, calcium hydroxide mixed with saline, and a Teflon formulation. The microbes used were Streptococcus mutans (a gram-positive microaerophile)...
December 1990: Oral Surgery, Oral Medicine, and Oral Pathology
S Karjalainen, L Forsten
Five "cream-like" intermediary bases (Hypocal¿, Dycal¿, Reocap¿, Cavitec¿ and Dropsin¿) were studied using ZnO-eugenol (ZOE) and phosphate cement for comparison. The in vitro experiments, which were designed to reveal the penetration of a dye and an etching liquid, showed that Dropsin and Hyypocal were permeable to dye and that Dropsin was permeable to acid as well. The in vivo experiments revealed no definite differences between the different cream-like base materials, nor were there differences between those and the conventional cements...
September 1975: Scandinavian Journal of Dental Research
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