Read by QxMD icon Read


Martina Fanna, Amandine Baptiste, Carmen Capito, Rocio Ortego, Raffaella Pacifico, Fabrice Lesage, Florence Moulin, Dominique Debray, Samira Sissaoui, Muriel Girard, Florence Lacaille, Caroline Telion, Caroline Elie, Yves Aigrain, Christophe Chardot
This study analyzes the preoperative risk factors for intra-operative bleeding in our recent series of pediatric LTs. Between November 2009 and November 2014, 84 consecutive isolated pediatric LTs were performed in 81 children. Potential preoperative predictive factors for bleeding, amount of intra-operative transfusions, postoperative course, and outcome were recorded. Cutoff point for intra-operative HBL was defined as intra-operative RBC transfusions ≥1 TBV. Twenty-six patients (31%) had intra-operative HBL...
September 29, 2016: Pediatric Transplantation
Dmitry Khodyakov, Sean Grant, Claire E H Barber, Deborah A Marshall, John M Esdaile, Diane Lacaille
RATIONALE, AIMS, AND OBJECTIVES: Online modified Delphi (OMD) panel approaches can be used to engage large and diverse groups of clinical experts and stakeholders in developing health services performance measures. Such approaches are increasing in popularity among health researchers. However, information about their acceptability to participating experts and stakeholders is lacking but important to determine before recommending widespread use of online approaches. Therefore, the objective of this paper is to explore acceptability of the OMD panel approach from the participants' perspective...
September 13, 2016: Journal of Evaluation in Clinical Practice
Sharan K Rai, J Antonio Aviña-Zubieta, Natalie McCormick, Mary A De Vera, Diane Lacaille, Eric C Sayre, Hyon K Choi
OBJECTIVE: Gout and rheumatoid arthritis (RA) are the two most common forms of inflammatory arthritis worldwide. As hospitalizations for both conditions lead to substantial health resource use, contemporary inpatient trends and associated costs may provide important benchmarks of disease burden. However, relevant data are limited. METHODS: We used PopulationData BC, a population-based administrative dataset from Canada. We examined trends in the annual hospitalization and surgery rate of gout and RA from 2000-2011...
August 26, 2016: Arthritis Care & Research
Jinoos Yazdany, Mark Robbins, Gabriela Schmajuk, Sonali Desai, Diane Lacaille, Tuhina Neogi, Jasvinder A Singh, Mark Genovese, Rachel Myslinski, Natalie Fisk, Melissa Francisco, Eric Newman
BACKGROUND: Electronic clinical quality measures (eCQMs) rely on computer algorithms to extract data from electronic health records (EHRs). On behalf of the American College of Rheumatology (ACR), we sought to develop and test eCQMs for rheumatoid arthritis (RA). METHODS: Drawing from published ACR guidelines, a working group developed candidate RA process measures and subsequently assessed face validity through an interdisciplinary panel of health care stakeholders...
August 26, 2016: Arthritis Care & Research
Karima Ounaissia, David Pertuit, Anne-Claire Mitaine-Offer, Tomofumi Miyamoto, Chiaki Tanaka, Stéphanie Delemasure, Patrick Dutartre, Dalila Smati, Marie-Aleth Lacaille-Dubois
From the aerial parts, pericarps and roots of Solenostemma argel, three new pregnane glycosides (1-3) with two known ones and a new phenolic glycoside (4) have been isolated. Their structures were established by extensive 1D - and 2D NMR and mass spectroscopic analysis. The cytotoxicity of all compounds was evaluated against two human tumor cell lines (SW 480, MCF-7), but none of them was active in the concentration range 0.9-59.0μM. Compounds 2 and the known argeloside F at non toxic concentrations for the PBMCs (27...
October 2016: Fitoterapia
Océane Dubray, Brice Moulari, Claire Chrétien, Yann Pellequer, Alf Lamprecht, Anne-Claire Mitaine-Offer, Marie-Aleth Lacaille-Dubois, Arnaud Béduneau
The oral bioavailability of drugs is often limited due to the presence of the P-glycoprotein, an efflux pump strongly expressed on the luminal side of the intestinal barrier. In an attempt to circumvent drug efflux, strategies consisting in the coadministration of drugs with surface-active agents have been found to be promising. In this context, the role of saponins on the intestinal permeability of a P-glycoprotein substrate was investigated. The P-glycoprotein inhibition activity of three triterpenoid saponins extracted from several plants of the Caryophyllaceae family was evaluated using an intestinal barrier model comprised of Caco-2 cell lines...
July 15, 2016: Planta Medica
Jinoos Yazdany, Rachel Myslinski, Amy Miller, Melissa Francisco, Sonali Desai, Gabriela Schmajuk, Diane Lacaille, Claire E Barber, Catalina Orozco, Matthew Bunyard, Martin J Bergman, Murray Passo, Eric L Matteson, Richard Olson, Stuart Silverman, Robert Warren, Kamala Nola, Mark Robbins
No abstract text is available yet for this article.
October 2016: Arthritis Care & Research
Nick Bansback, Kam Shojania, Diane Lacaille
No abstract text is available yet for this article.
June 27, 2016: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
Elsa Rossignol, Lionel Carmant, Jean-Claude Lacaille
No abstract text is available yet for this article.
2016: Progress in Brain Research
Claire Huth, Étienne Pigeon, Marie-Ève Riou, Josée St-Onge, Hélène Arguin, Erick Couillard, Marie-Julie Dubois, André Marette, Angelo Tremblay, S John Weisnagel, Michel Lacaille, Pascale Mauriège, Denis R Joanisse
Adiposopathy, or sick fat, refers to adipose tissue dysfunction that can lead to several complications such as dyslipidemia, insulin resistance, and hyperglycemia. The relative contribution of adiposopathy in predicting insulin resistance remains unclear. We investigated the relationship between adiposopathy, as assessed as a low plasma adiponectin/leptin ratio, with anthropometry, body composition (hydrostatic weighing), insulin sensitivity (hyperinsulinemic-euglycemic clamp), inflammation, and fitness level (ergocycle VO2max, mL/kgFFM/min) in 53 men (aged 34-53 years) from four groups: sedentary controls without obesity (body mass index [BMI] <25 kg/m(2)), sedentary with obesity (BMI > 30 kg/m(2)), sedentary with obesity and glucose intolerance, and endurance trained active without obesity...
September 2016: Journal of Physiology and Biochemistry
Barbara Haber, Estella Alonso, Alejandra Pedreira, Norberto Rodriguez-Baez, Mirta Ciocca, Florence Lacaille, Thomas Lang, Teresita Gonzalez, Zachary Goodman, Zijiang Yang, Beth Jackson, Stephanie Noviello, Janice K Albrecht
OBJECTIVES: To describe the 5-year follow-up of children who received peginterferon and ribavirin in a global, open-label study. METHODS: A 5-year follow-up study of 107 children and adolescents aged 3-17 years with chronic hepatitis C virus infection who received peginterferon and ribavirin for 24 or 48 weeks. No drugs were administered during follow-up. RESULTS: Ninety-four patients were enrolled in the long-term follow-up portion of the study; the median duration of follow-up was 287 weeks (range, 73-339)...
April 21, 2016: Journal of Pediatric Gastroenterology and Nutrition
Simon van Genderen, Guy Plasqui, Robert Landewé, Diane Lacaille, Suzanne Arends, Floris van Gaalen, Désirée van der Heijde, Liesbeth Heuft, Jolanda Luime, Anneke Spoorenberg, Monique A M Gignac, Annelies Boonen
OBJECTIVE: Social role participation of persons with a chronic disease is important for their lives, but interpretation of data on participation is difficult in the absence of a benchmark. This study aimed to compare social role participation in patients with ankylosing spondylitis (AS) to population controls using the social role participation questionnaire (SRPQ). METHODS: 246 AS patients and 510 population controls completed the SRPQ which assesses participation in eleven roles (score range 1-5) across four dimensions (importance, satisfaction with performance, satisfaction with time, and difficulty), and additionally ranked their three most important roles...
April 5, 2016: Arthritis Care & Research
Elie Abi Nader, Cécile Lambe, Cécile Talbotec, Bénédicte Pigneur, Florence Lacaille, Hélène Garnier-Lengliné, Laetitia-Marie Petit, Catherine Poisson, Amélia Rocha, Odile Corriol, Yves Aigrain, Christophe Chardot, Frank M Ruemmele, Virginie Colomb-Jung, Olivier Goulet
BACKGROUND: Parenteral nutrition (PN) is the main treatment for intestinal failure. OBJECTIVE: We aimed to review the indications for home parenteral nutrition (HPN) in children and describe the outcome over a 14-y period from a single center. DESIGN: We conducted a retrospective study that included all children who were referred to our institution and discharged while receiving HPN between 1 January 2000 and 31 December 2013. The indications for HPN were divided into primary digestive diseases (PDDs) and primary nondigestive diseases (PNDDs)...
May 2016: American Journal of Clinical Nutrition
Turibio Kuiate Tabopda, Anne-Claire Mitaine-Offer, Thomas Paululat, Stéphanie Delemasure, Patrick Dutartre, Bonaventure Tchaleu Ngadjui, Marie-Aleth Lacaille-Dubois
Phytochemical investigation of the aerial parts of Chlorophytum deistelianum led to the isolation of four previously undescribed steroidal saponins called chlorodeistelianosides A-D with five known ones. Their structures were established mainly by extensive 1D and 2D NMR spectroscopic techniques and mass spectrometry as (25R)-3β-[(β-D-glucopyranosyl-(1→3)-[α-L-rhamnopyranosyl-(1→4)]-β-D-xylopyranosyl-(1→3)-[β-D-glucopyranosyl-(1→2)]-β-D-glucopyranosyl-(1→4)-β-D-galactopyranosyl)oxy]-5α-spirostan-12-one, (24S,25S)-24-[(β-D-glucopyranosyl)oxy]-3β-[(β-d-glucopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→3)]-β-D-glucopyranosyl-(1→4)-β-D-galactopyranosyl)oxy]-5α-spirostan-12-one, (25R)-26-[(β-D-glucopyranosyl)oxy]-2α-hydroxy-22α-methoxy-5α-furostan-3β-yl β-D-glucopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→3)]-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside, and (25R)-26-[(β-D-glucopyranosyl)oxy]-3β-[(β-D-glucopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→3)]-β-D-glucopyranosyl-(1→4)-β-D-galactopyranosyl)oxy]-5α-furost-20(22)-en-12-one...
June 2016: Phytochemistry
Sibel Avunduk, Anne-Claire Mitaine-Offer, Tomofumi Miyamoto, Chiaki Tanaka, Marie-Aleth Lacaille-Dubois
Five known cycloartane-type glycosides were isolated from the roots of A. tmoleus Boiss. var. tmoleus. The identification of these compounds was mainly achieved by 1D and 2D NMR spectroscopic techniques and FABMS. The results of our studies confirm that triterpene saponins with the cycloartane-type skeleton might be chemotaxonomically significant for the genus Astragalus.
January 2016: Natural Product Communications
Caroline Cruysmans, Marie-Gabrielle Ferneiny, Sylvie Fraitag, Pierre Frange, Christophe Chardot, Christine Bodemer, Olivier Goulet, Florence Lacaille
BACKGROUND: Severe skin problems are uncommon after small bowel transplantation. Differential diagnosis includes drug reactions, infections, graft-versus-host disease (GVHD), and mixed diseases. Early diagnosis and treatment are determinant for prognosis. METHODS AND RESULTS: We describe 6 patients with severe cutaneous complications after small bowel transplantation, the work-up, final diagnosis, and evolution. Two patients died from chronic GVHD or unrecognized drug rash with eosinophilia and systemic symptoms, the others recovered completely...
October 2016: Transplantation
Lara J LaCaille, Jennifer Feenstra Schultz, Ryan Goei, Rick A LaCaille, Kim Nichols Dauner, Rebecca de Souza, Amy Versnik Nowak, Ronald Regal
BACKGROUND: Worksite obesity prevention interventions using an ecological approach may hold promise for reducing typical weight gain. The purpose of this study was to examine the effectiveness of Go!, an innovative 12-month multi-component worksite obesity prevention intervention. METHODS: A quasi-experimental non-equivalent control group design was utilized; 407 eligible hospital employees (intervention arm) and 93 eligible clinic employees (comparison arm) participated...
2016: BMC Public Health
Simon van Genderen, Guy Plasqui, Diane Lacaille, Suzanne Arends, Floris van Gaalen, Désirée van der Heijde, Liesbeth Heuft, András Keszei, Jolanda Luime, Anneke Spoorenberg, Robert Landewé, Monique Gignac, Annelies Boonen
OBJECTIVE: The Social Role Participation Questionnaire (SRPQ) assesses the influence of health on participation in 11 specific and one general participation role across 4 participation dimensions: 'importance', 'satisfaction with time', 'satisfaction with performance' and 'physical difficulty'. This study aimed to translate the SRPQ into Dutch, and assess the clinimetric properties and aspects of its validity among patients with ankylosing spondylitis (AS). METHODS: Translation was performed using the dual panel approach...
2016: RMD Open
F Lacaille
"Cholestasis" means abnormal synthesis or secretion of bile. The main symptom in a neonate or infant is jaundice. Urine is dark, staining diapers, and stools are variably pale or white. Vitamin K should be injected (to prevent coagulation disorders due to malabsorption). The two diagnoses requiring urgent treatment are urinary tract infection and biliary atresia. If stools are permanently white, biliary atresia is highly probable. A few genetic causes of intrahepatic cholestasis should be screened and corrective surgery organized...
March 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Z Demir, P Frange, F Lacaille
Vaccination is an effective strategy to decrease infections in transplant recipients. Children after intestinal transplantation carry a high risk of infection due to increased immunosuppression. In a series of 22 children after intestinal transplantation, we studied the vaccination schedules and the antibodies against vaccine-preventable diseases before transplantation, and at one and five yr after transplantation. We reviewed whether the vaccination schedules were complete, and we analysed the factors that may influence serological immunity and the incidence of disease in patients with deficient immunity...
May 2016: Pediatric Transplantation
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"