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https://www.readbyqxmd.com/read/28202740/health-equity-considerations-for-developing-and-reporting-patient-reported-outcomes-in-clinical-trials-a-report-from-the-omeract-equity-special-interest-group
#1
Jennifer Petkovic, Jennifer L Barton, Caroline Flurey, Niti Goel, Christie M Bartels, Cheryl Barnabe, Maarten P T de Wit, Anne Lyddiatt, Diane Lacaille, Vivian Welch, Annelies Boonen, Beverley Shea, Robin Christensen, Lara J Maxwell, Willemina Campbell, Janet Jull, Karine Toupin-April, Jasvinder A Singh, Charles H Goldsmith, Antoine G Sreih, Christoph Pohl, Catherine Hofstetter, Dorcas E Beaton, Rachelle Buchbinder, Francis Guillemin, Peter S Tugwell
OBJECTIVE: Despite advances integrating patient-centered outcomes into rheumatologic studies, concerns remain regarding their representativeness across diverse patient groups and how this affects equity. The Outcome Measures in Rheumatology (OMERACT) Equity Working Group aims to determine whether and how to address equity issues within the core outcome sets of domains and instruments. METHODS: We surveyed current and previous OMERACT meeting attendees and members of the Campbell and Cochrane Equity Group regarding whether to address equity issues within the OMERACT Filter 2...
February 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28102526/hormonal-and-reproductive-factors-and-the-risk-of-ovarian-cancer
#2
Anita Koushik, Anne Grundy, Michal Abrahamowicz, Jocelyne Arseneau, Lucy Gilbert, Walter H Gotlieb, Julie Lacaille, Anne-Marie Mes-Masson, Marie-Élise Parent, Diane M Provencher, Lesley Richardson, Jack Siemiatycki
PURPOSE: Hormone-related factors have been associated with ovarian cancer, the strongest being parity and oral contraceptive use. Given reductions in birth rates and increases in oral contraceptive use over time, associations in more recent birth cohorts may differ. Furthermore, consideration of ovarian cancer heterogeneity (i.e., Type I/II invasive cancers) may contribute to a better understanding of etiology. We examined hormone-related factors in relation to ovarian cancer risk overall, for Type I and Type II cancers, as well as borderline tumors...
January 19, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28089231/-mother-to-child-transmission-of-hepatitis-b-virus-despite-postexposure-prophylaxis-a-review-of-the-literature-and-description-of-11%C3%A2-observations
#3
B Biot, N Laverdure, F Lacaille, A Lachaux
Chronic hepatitis B virus (HBV) infection leads to a risk of developing cirrhosis and hepatocellular carcinoma. In France, where the prevalence of HBV is low, mother-to-child transmission is the cause of chronic infection in more than one-third of cases. After exposure, the risk of chronic infection is the highest for newborns (90 %). The World Health Organization implemented a global immunization program in 1991, applied in France in 1994. A significant number of children are infected each year, however, and failure of postexposure prophylaxis is reported in 4-10 % of newborns...
February 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28031164/improvement-in-5-year-mortality-in-incident-rheumatoid-arthritis-compared-with-the-general-population-closing-the-mortality-gap
#4
Diane Lacaille, J Antonio Avina-Zubieta, Eric C Sayre, Michal Abrahamowicz
OBJECTIVE: Excess mortality in rheumatoid arthritis (RA) is expected to have improved over time, due to improved treatment. Our objective was to evaluate secular 5-year mortality trends in RA relative to general population controls in incident RA cohorts diagnosed in 1996-2000 vs 2001-2006. METHODS: We conducted a population-based cohort study, using administrative health data, of all incident RA cases in British Columbia who first met RA criteria between January 1996 and December 2006, with general population controls matched 1:1 on gender, birth and index years...
December 28, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27975684/triterpene-glycosides-from-plants-for-antibody-recognition
#5
E Peroni, F Real Fernández, C Gheri, F Nuti, A C Mitaine-Offer, F Lolli, M A Lacaille-Dubois, A M Papini
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27975683/steroidal-saponins-from-chlorophytum-deistelianum
#6
T Tabopda, A C Mitaine-Offer, T Paululat, S Delemasure, P Dutartre, B T Ngadjui, M A Lacaille-Dubois
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27975525/oleanane-type-saponins-from-the-roots-of-wisteria-floribunda-macrobotrys
#7
A S Champy, A C Mitaine-Offer, T Paululat, A M Papini, M A Lacaille-Dubois
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27960218/saponins-current-progress-and-perspectives
#8
Marie-Aleth Lacaille-Dubois, Matthias F Melzig
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27909087/stand-up-and-be-counted-measuring-and-mapping-the-rheumatology-workforce-in-canada
#9
Claire E H Barber, Lauren Jewett, Elizabeth M Badley, Diane Lacaille, Alfred Cividino, Vandana Ahluwalia, Henry Averns, Cory Baillie, Janet Ellsworth, Janet Pope, Deborah Levy, Christine Charnock, Claire McGowan, J Carter Thorne, Cheryl Barnabe, Michel Zummer, Katie Lundon, Robert S McDougall, John G Thomson, Elaine A Yacyshyn, Dianne Mosher, Julie Brophy, Thanu Nadarajah Ruban, Deborah A Marshall
OBJECTIVE: To characterize the practicing rheumatologist workforce, the Canadian Rheumatology Association (CRA) launched the Stand Up and Be Counted workforce survey in 2015. METHODS: The survey was distributed electronically to 695 individuals, of whom 519 were expected to be practicing rheumatologists. Demographic and practice information were elicited. We estimated the number of full-time equivalent rheumatologists per 75,000 population from the median proportion of time devoted to clinical practice multiplied by provincial rheumatologist numbers from the Canadian Medical Association...
December 1, 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27898598/pharmacokinetics-of-mycophenolic-acid-and-dose-optimization-in-children-after-intestinal-transplantation
#10
Caroline Barau, Antonio Mellos, Stéphanie Chhun, Florence Lacaille, Valérie Furlan
BACKGROUND: Mycophenolate mofetil (MMF) or enteric-coated mycophenolate sodium (MPS) are now commonly used in pediatric intestinal transplantation (Tx), but to date, no clear recommendations regarding the dosing regimen have been made in this population. The aim of this study was to determine the MMF/MPS dosage required to achieve an area under the plasma concentration-time curve from 0 to 12 hours (AUC0-12) for mycophenolic acid (MPA) greater than 30 mg.h/L in children after intestinal transplantation...
November 28, 2016: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/27889929/twenty-eight-years-of-intestinal-transplantation-in-paris-experience-of-the-oldest-european-centre
#11
F Lacaille, S Irtan, L Dupic, C Talbotec, F Lesage, V Colomb, N Salvi, F Moulin, F Sauvat, Y Aigrain, Y Revillon, O Goulet, C Chardot
AIM: Our aim is to describe our achievements in pediatric intestinal transplantation (ITx) and define areas for improvement. METHODS: After a period (1987-90) of 9 isolated small bowel transplants (SBTx) where only one patient survived with her graft, 110 ITx were performed on 101 children from 1994 to 2014: 60 SBTx, 45 liver-small bowel, 4 multivisceral (3 with kidneys), 1 modified multivisceral. Indications were short bowel syndrome (36), motility disorders (30), congenital enteropathies (34) and others (1)...
November 27, 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/27859693/structural-analysis-of-oleanane-type-saponins-from-the-roots-of-wisteria-frutescens
#12
Anne-Sophie Champy, Anne-Claire Mitaine-Offer, Tomofumi Miyamoto, Chiaki Tanaka, Anna-Maria Papini, Marie-Aleth Lacaille-Dubois
No abstract text is available yet for this article.
November 8, 2016: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/27827368/decrease-of-syngap1-in-gabaergic-cells-impairs-inhibitory-synapse-connectivity-synaptic-inhibition-and-cognitive-function
#13
Martin H Berryer, Bidisha Chattopadhyaya, Paul Xing, Ilse Riebe, Ciprian Bosoi, Nathalie Sanon, Judith Antoine-Bertrand, Maxime Lévesque, Massimo Avoli, Fadi F Hamdan, Lionel Carmant, Nathalie Lamarche-Vane, Jean-Claude Lacaille, Jacques L Michaud, Graziella Di Cristo
Haploinsufficiency of the SYNGAP1 gene, which codes for a Ras GTPase-activating protein, impairs cognition both in humans and in mice. Decrease of Syngap1 in mice has been previously shown to cause cognitive deficits at least in part by inducing alterations in glutamatergic neurotransmission and premature maturation of excitatory connections. Whether Syngap1 plays a role in the development of cortical GABAergic connectivity and function remains unclear. Here, we show that Syngap1 haploinsufficiency significantly reduces the formation of perisomatic innervations by parvalbumin-positive basket cells, a major population of GABAergic neurons, in a cell-autonomous manner...
November 9, 2016: Nature Communications
https://www.readbyqxmd.com/read/27826748/pacap-protects-the-adolescent-and-adult-mice-brain-from-ethanol-toxicity-and-modulates-distinct-sets-of-genes-regulating-similar-networks
#14
Hélène Lacaille, Dominique Duterte-Boucher, Hubert Vaudry, Yasmine Zerdoumi, Jean-Michel Flaman, Hitoshi Hashimoto, David Vaudry
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 38-amino acid neuropeptide which has been shown to exert various neuroprotective actions in vitro and in vivo; however, the ability of endogenous PACAP to prevent cell death in vivo remains to be elucidated. To explore the capacity of endogenous PACAP to prevent ethanol toxicity, adolescent and adult PACAP knockout (KO) mice were injected with ethanol in a binge drinking-like manner. Biochemical analyses revealed that ethanol administration induced an increase in the production of reactive oxygen species and the activity of caspase-3 in PACAP KO mice in an age-independent manner...
November 8, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27681842/preoperative-risk-factors-for-intra-operative-bleeding-in-pediatric-liver-transplantation
#15
Martina Fanna, Amandine Baptiste, Carmen Capito, Rocio Ortego, Raffaella Pacifico, Fabrice Lesage, Florence Moulin, Dominique Debray, Samira Sissaoui, Muriel Girard, Florence Lacaille, Caroline Telion, Caroline Elie, Yves Aigrain, Christophe Chardot
This study analyzes the preoperative risk factors for intra-operative bleeding in our recent series of pediatric LTs. Between November 2009 and November 2014, 84 consecutive isolated pediatric LTs were performed in 81 children. Potential preoperative predictive factors for bleeding, amount of intra-operative transfusions, postoperative course, and outcome were recorded. Cutoff point for intra-operative HBL was defined as intra-operative RBC transfusions ≥1 TBV. Twenty-six patients (31%) had intra-operative HBL...
December 2016: Pediatric Transplantation
https://www.readbyqxmd.com/read/27619536/acceptability-of-an-online-modified-delphi-panel-approach-for-developing-health-services-performance-measures-results-from-3-panels-on-arthritis-research
#16
Dmitry Khodyakov, Sean Grant, Claire E H Barber, Deborah A Marshall, John M Esdaile, Diane Lacaille
RATIONALE, AIMS, AND OBJECTIVES: Online modified Delphi (OMD) panel approaches can be used to engage large and diverse groups of clinical experts and stakeholders in developing health services performance measures. Such approaches are increasing in popularity among health researchers. However, information about their acceptability to participating experts and stakeholders is lacking but important to determine before recommending widespread use of online approaches. Therefore, the objective of this paper is to explore acceptability of the OMD panel approach from the participants' perspective...
September 13, 2016: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/27565008/trends-in-gout-and-rheumatoid-arthritis-hospitalizations-in-canada-from-2000-2011
#17
Sharan K Rai, J Antonio Aviña-Zubieta, Natalie McCormick, Mary A De Vera, Diane Lacaille, Eric C Sayre, Hyon K Choi
OBJECTIVE: Gout and rheumatoid arthritis (RA) are the two most common forms of inflammatory arthritis worldwide. As hospitalizations for both conditions lead to substantial health resource use, contemporary inpatient trends and associated costs may provide important benchmarks of disease burden. However, relevant data are limited. METHODS: We used PopulationData BC, a population-based administrative dataset from Canada. We examined trends in the annual hospitalization and surgery rate of gout and RA from 2000-2011...
August 26, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27564778/development-of-the-american-college-of-rheumatology-s-rheumatoid-arthritis-electronic-clinical-quality-measures
#18
Jinoos Yazdany, Mark Robbins, Gabriela Schmajuk, Sonali Desai, Diane Lacaille, Tuhina Neogi, Jasvinder A Singh, Mark Genovese, Rachel Myslinski, Natalie Fisk, Melissa Francisco, Eric Newman
OBJECTIVE: Electronic clinical quality measures (eCQMs) rely on computer algorithms to extract data from electronic health records (EHRs). On behalf of the American College of Rheumatology (ACR), we sought to develop and test eCQMs for rheumatoid arthritis (RA). METHODS: Drawing from published ACR guidelines, a working group developed candidate RA process measures and subsequently assessed face validity through an interdisciplinary panel of health care stakeholders...
November 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27511059/new-pregnane-and-phenolic-glycosides-from-solenostemma-argel
#19
Karima Ounaissia, David Pertuit, Anne-Claire Mitaine-Offer, Tomofumi Miyamoto, Chiaki Tanaka, Stéphanie Delemasure, Patrick Dutartre, Dalila Smati, Marie-Aleth Lacaille-Dubois
From the aerial parts, pericarps and roots of Solenostemma argel, three new pregnane glycosides (1-3) with two known ones and a new phenolic glycoside (4) have been isolated. Their structures were established by extensive 1D - and 2D NMR and mass spectroscopic analysis. The cytotoxicity of all compounds was evaluated against two human tumor cell lines (SW 480, MCF-7), but none of them was active in the concentration range 0.9-59.0μM. Compounds 2 and the known argeloside F at non toxic concentrations for the PBMCs (27...
October 2016: Fitoterapia
https://www.readbyqxmd.com/read/27420349/triterpenoid-saponins-from-the-caryophyllaceae-family-modulate-the-efflux-activity-of-the-p-glycoprotein-in-an-in-vitro-model-of-intestinal-barrier
#20
Océane Dubray, Brice Moulari, Claire Chrétien, Yann Pellequer, Alf Lamprecht, Anne-Claire Mitaine-Offer, Marie-Aleth Lacaille-Dubois, Arnaud Béduneau
The oral bioavailability of drugs is often limited due to the presence of the P-glycoprotein, an efflux pump strongly expressed on the luminal side of the intestinal barrier. In an attempt to circumvent drug efflux, strategies consisting in the coadministration of drugs with surface-active agents have been found to be promising. In this context, the role of saponins on the intestinal permeability of a P-glycoprotein substrate was investigated. The P-glycoprotein inhibition activity of three triterpenoid saponins extracted from several plants of the Caryophyllaceae family was evaluated using an intestinal barrier model comprised of Caco-2 cell lines...
December 2016: Planta Medica
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