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https://www.readbyqxmd.com/read/29343274/coexistent-sickle-cell-anemia-and-autoimmune-disease-in-eight-children-pitfalls-and-challenges
#1
Valerie Li-Thiao-Te, Florence Uettwiller, Pierre Quartier, Florence Lacaille, Brigitte Bader-Meunier, Valentine Brousse, Mariane de Montalembert
BACKGROUND: Patients with sickle cell disease (SCD) present a defective activation of the alternate complement pathway that increases the risk of infection and is thought to predispose to autoimmune disease (AID). However, coexisting AID and SCD is rarely reported, suggesting possible underdiagnosis due to an overlapping of the symptoms. STUDY DESIGN: Among 603 patients with SCD followed between 1999 and June 2016, we retrospectively searched for patients with coexisting SCD and AID...
January 17, 2018: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29316190/life-of-patients-10-years-after-a-successful-pediatric-intestinal-transplantation-in-europe
#2
Lorenzo Norsa, Girish Gupte, Esther Ramos Boluda, Francisca Joly, Olivier Corcos, Jacques Pirenne, Gustaf Herlenius, Florence Lacaille
A multicenter Europe-wide single point study in intestinal transplantation (ITx) centers was conducted to identify and describe patients surviving for more than 10 years after ITx in childhood. The health and nutritional status, care requirements and psychosocial status were recorded. Among 120 transplanted before 2005, 38 patients with a functioning graft were included. Thirty (79%) had an exclusive oral diet, 7 (18%) complimentary enteral nutrition for eating disorders, one a combination of parenteral and enteral nutrition...
January 9, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29239784/new-perspectives-for-natural-triterpene-glycosides-as-potential-adjuvants
#3
Marie-Aleth Lacaille-Dubois, Hildebert Wagner
BACKGROUND: Triterpene glycosides are a vast group of secondary metabolites widely distributed in plants including a high number of biologically active compounds. The pharmacological potential is evaluated by using many bioassays particularly in the field of cancerology, immunology, and microbiology. The adjuvant concept is well known for these molecules in vaccines, but there is little preclinical evidence to support this concept in the management of cancer, infections and inflammation...
November 7, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29211721/galaxy-growth-in-a-massive-halo-in-the-first-billion-years-of-cosmic-history
#4
D P Marrone, J S Spilker, C C Hayward, J D Vieira, M Aravena, M L N Ashby, M B Bayliss, M Béthermin, M Brodwin, M S Bothwell, J E Carlstrom, S C Chapman, Chian-Chou Chen, T M Crawford, D J M Cunningham, C De Breuck, C D Fassnacht, A H Gonzalez, T R Greve, Y D Hezaveh, K Lacaille, K C Litke, S Lower, J Ma, M Malkan, T B Miller, W R Morningstar, E J Murphy, D Narayanan, K A Phadke, K M Rotermund, J Sreevani, B Stalder, A A Stark, M L Strandet, M Tang, A Weiß
According to the current understanding of cosmic structure formation, the precursors of the most massive structures in the Universe began to form shortly after the Big Bang, in regions corresponding to the largest fluctuations in the cosmic density field. Observing these structures during their period of active growth and assembly-the first few hundred million years of the Universe-is challenging because it requires surveys that are sensitive enough to detect the distant galaxies that act as signposts for these structures and wide enough to capture the rarest objects...
December 6, 2017: Nature
https://www.readbyqxmd.com/read/29174732/disinhibition-in-learning-and-memory-circuits-new-vistas-for-somatostatin-interneurons-and-long-term-synaptic-plasticity
#5
REVIEW
Julien Artinian, Jean-Claude Lacaille
Neural circuit functions involve finely controlled excitation/inhibition interactions that allow complex neuronal computations and support high order brain functions such as learning and memory. Disinhibition, defined as a transient brake on inhibition that favors excitation, recently appeared to be a conserved circuit mechanism implicated in various functions such as sensory processing, learning and memory. Although vasoactive intestinal polypeptide (VIP) interneurons are considered to be the main disinhibitory cells, recent studies highlighted a pivotal role of somatostatin (SOM) interneurons in inhibiting GABAergic interneurons and promoting principal cell activation...
November 23, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/29047218/risk-of-incident-chronic-obstructive-pulmonary-disease-copd-in-rheumatoid-arthritis-a-population-based-cohort-study
#6
Katherine McGuire, J Antonio Avina-Zubieta, John M Esdaile, Mohsen Sadatsafavi, Eric C Sayre, Michal Abrahamowicz, Diane Lacaille
OBJECTIVE: Studies have demonstrated a link between COPD and inflammation, raising the question whether chronic inflammatory conditions, such as RA, predispose to COPD. Our objective was to evaluate the risk of incident COPD hospitalization in RA compared to the general population. METHODS: We studied a population-based incident RA cohort with matched general population controls, using administrative health data.. All incident RA cases in British Columbia (BC) who first met RA definition between 01/1996 and 12/2006 were selected using previously published criteria...
October 19, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28966205/development-of-a-canadian-core-clinical-dataset-to-support-high-quality-care-for-canadian-patients-with-rheumatoid-arthritis
#7
Claire E H Barber, Dianne P Mosher, Vandana Ahluwalia, Michel Zummer, Deborah A Marshall, Denis Choquette, Diane Lacaille, Claire Bombardier, Anne Lyddiatt, Vinod Chandran, Dmitry Khodyakov, Emily Dao, Cheryl Barnabe
OBJECTIVE: To develop a Canadian Rheumatoid Arthritis Core Clinical Dataset (CAN-RACCD) to standardize documentation encouraging high-quality care. METHODS: A set of candidate elements was drafted through meetings with 27 rheumatologists, researchers, and patients, and supplemented with focused literature reviews. A 3-round online-modified Delphi consensus process was held with rheumatologists (n = 26), allied health professionals (n = 7), and patients (n = 4); for the remainder there was no demographic information...
October 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28925053/extracorporeal-membrane-oxygenation-can-save-lives-in-children-with-heart-or-lung-failure-after-liver-transplantation
#8
Sandrine Jean, Christophe Chardot, Mehdi Oualha, Carmen Capito, Olivier Bustarret, Philippe Pouard, Sylvain Renolleau, Florence Lacaille, Laurent Dupic
The risk of cardiac or lung failure after liver transplantation (LT) is significant. In rare cases, the usual intensive care techniques fail to maintain organ oxygenation with a risk of multiorgan dysfunction. Although extracorporeal membrane oxygenation (ECMO) is a difficult and risky procedure, it can be proposed as life-saving. Four children with either acute pulmonary (three) or cardiac (one) failure after LT, and the criteria that decided the use of ECMO (level of ventilation and results, dosage of inotropic drugs, cardiac ultrasound, blood lactate) were retrospectively reported...
September 2017: Artificial Organs
https://www.readbyqxmd.com/read/28856627/autism-spectrum-disorders-in-propionic-acidemia-patients
#9
Caroline Dejean de la Bâtie, Valérie Barbier, Célina Roda, Anaïs Brassier, Jean-Baptiste Arnoux, Vassili Valayannopoulos, Anne-Sophie Guemann, Clément Pontoizeau, Stéphanie Gobin, Florence Habarou, Florence Lacaille, Jean-Paul Bonnefont, Pierre Canouï, Chris Ottolenghi, Pascale De Lonlay, Lisa Ouss
Propionic acidemia is the result of a deficiency in propionyl-CoA carboxylase activity. Chronic neurologic and cognitive complications frequently occur, but the psychiatric evolution of the disorder is not well documented. We conducted a pedopsychiatric evaluation of 19 children, adolescents and young adults, aged between 2 and 25 years, using ADI-R, CARS-T, as well as ADOS when autism spectrum disorder was suspected. Previous psychometric examinations were also taken into consideration. Thirteen patients had an IQ < 80...
August 30, 2017: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/28821679/upf1-governs-synaptic-plasticity-through-association-with-a-stau2-rna-granule
#10
Tyson E Graber, Erika Freemantle, Mina N Anadolu, Sarah Hébert-Seropian, Robyn L MacAdam, Unkyung Shin, Huy-Dung Hoang, Tommy Alain, Jean-Claude Lacaille, Wayne S Sossin
Neuronal mRNAs can be packaged in reversibly stalled polysome granules before their transport to distant synaptic locales. Stimulation of synaptic metabotropic glutamate receptors (mGluRs) reactivates translation of these particular mRNAs to produce plasticity-related protein; a phenomenon exhibited during mGluR-mediated LTD. This form of plasticity is deregulated in Fragile X Syndrome, a monogenic form of autism in humans, and understanding the stalling and reactivation mechanism could reveal new approaches to therapies...
September 20, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28816015/liver-transplantation-in-adult-cystic-fibrosis-clinical-imaging-and-pathological-evidence-of-obliterative-portal-venopathy
#11
LETTER
Sophie Hillaire, Dominique Cazals-Hatem, Onorina Bruno, Sandra de Miranda, Dominique Grenet, Nicolas Poté, Olivier Soubrane, Serge Erlinger, Florence Lacaille, Francois Mellot, Valerie Vilgrain, Valerie Paradis
No abstract text is available yet for this article.
October 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28777125/successful-use-of-sirolimus-in-children-with-large-mesenteric-lymphatic-lesions
#12
Swellen Gastineau, Giulia Paolella, Cécile Talbotec, Virginie Verkarre, Frédérique Sauvat, Olivier Goulet, Sylvie Fraitag, Florence Lacaille
No abstract text is available yet for this article.
August 2, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28759111/daily-mindful-responding-mediates-the-effect-of-meditation-practice-on-stress-and-mood-the-role-of-practice-duration-and-adherence
#13
Julien Lacaille, Gentiana Sadikaj, Midori Nishioka, Kimberly Carrière, Joseph Flanders, Bärbel Knäuper
OBJECTIVE: Although meditation practice is an important component of many mindfulness-based interventions (MBIs), empirical findings of its effects on psychological functioning are mixed and the mechanisms for the effects remain unclear. Responding with mindfulness (i.e., returning one's attention back to a nonjudgmental, present-oriented awareness) is a fundamental skill practiced in meditations. With repeated meditation practice, this skill is thought to become internalized and be applied to one's daily life...
July 31, 2017: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/28752490/do-biologic-therapies-for-rheumatoid-arthritis-offset-treatment-related-resource-utilization-and-cost-a-review-of-the-literature-and-an-instrumental-variable-analysis
#14
REVIEW
Nick Bansback, Eric Fu, Huiying Sun, Daphne Guh, Wei Zhang, Diane Lacaille, Katherine Milbers, Aslam H Anis
PURPOSE OF REVIEW: One justification for using expensive biologic therapy in rheumatoid arthritis (RA) has been that it can reduce future healthcare utilization such as joint surgeries and physician visits. However, the evidence to support this assertion is unclear. We conducted a review of the literature for studies which have analyzed the trends in resource use of RA patients, and then undertook a retrospective observational analysis of a Canadian administrative database using instrumental variable methods...
September 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/28622457/social-role-participation-and-satisfaction-with-life-a-study-among-patients-with-ankylosing-spondylitis-and-population-controls
#15
Simon van Genderen, Guy Plasqui, Désirée van der Heijde, Floris van Gaalen, Liesbeth Heuft, Jolanda Luime, Anneke Spoorenberg, Suzanne Arends, Diane Lacaille, Monique Gignac, Robert Landewé, Annelies Boonen
OBJECTIVE: Participation in society of persons with chronic diseases receives increasing attention. However, little is known which components of participation are most relevant to life satisfaction. This study examines the association between several aspects of social role participation and satisfaction with life (SWL) in patients with ankylosing spondylitis (AS) compared to population controls. METHODS: In a cross-sectional study, participants completed the Social Role Participation Questionnaire (SRPQ) and SWL scale...
June 16, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28599241/triterpene-saponins-from-billia-rosea
#16
Luis De Freitas, Doris Jimenez, Sherley Pimentel, Anne-Claire Mitaine-Offer, Laurent Pouységu, Stéphane Quideau, Thomas Paululat, Freddy Gonzalez-Mujica, Luis B Rojas, María Rodríguez, Marie-Aleth Lacaille-Dubois
Five previously undescribed triterpene saponins, billiosides A-E, and a known analogue, were isolated from the seeds of Billia rosea (Planch. & Linden) C. Ulloa & P. Jørg. Their structures were elucidated on the basis of extensive 1D and 2D NMR experiments ((1)H, (13)C, DEPT, COSY, TOCSY, NOESY, ROESY, HSQC, and HMBC) and mass spectrometry as (3β,21β,22α)-3-[(2-O-β-D-glucopyranosyl-O-[α-L-arabinopyranosyl-(1 → 4)]-β-D-glucopyranosyl)oxy]-21-[((2E,6S)-2,6-dimethyl-6-hydroxyocta-2,7-dienoyl)oxy]-22-(acetyloxy)-24-hydroxyolean-12-en-28-oic acid, (3β,21β,22α)-3-[(2-O-β-D-galactopyranosyl-β-D-glucopyranosyl)oxy]-21,22-dihydroxyolean-12-en-28-yl O-α-L-arabinopyranosyl-(1 → 4)-β-D-glucopyranoside, (3β,21β,22α)-3-[(2-O-β-D-galactopyranosyl-O-[α-L-arabinopyranosyl-(1 → 4)]-β-D-xylopyranosyl)oxy]-21,22-dihydroxyolean-12-en-28-yl O-β-D-glucopyranoside, (3β,21β,22α)-3-[(2-O-β-D-galactopyranosyl-O-[α-L-arabinopyranosyl-(1 → 4)]-β-D-glucopyranosyl)oxy]-21,22-dihydroxyolean-12-en-28-yl O-β-D-glucopyranoside, (3β,21β,22α)-3-[(2-O-β-D-galactopyranosyl-O-[α-L-arabinopyranosyl-(1 → 4)]-β-D-glucopyranosyl)oxy]-21,22-dihydroxyolean-12-en-28-yl O-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranoside, and dipteroside A...
September 2017: Phytochemistry
https://www.readbyqxmd.com/read/28544648/effects-of-a-web-based-patient-decision-aid-on-biologic-and-small-molecule-agents-for-rheumatoid-arthritis-answer-2-a-proof-of-concept-study
#17
Linda C Li, Chris Shaw, Diane Lacaille, Elaine Yacyshyn, C Allyson Jones, Cheryl Koehn, Alison M Hoens, Jasmina Geldman, Eric C Sayre, Graham Macdonald, Jenny Leese, Nick Bansback
OBJECTIVES: To assess the extent to which ANSWER-2, an interactive online patient decision aid, reduces patients' decisional conflict and improves their medication-related knowledge and self-management capacity. METHODS: We used a pre-post study design. Eligible participants had a diagnosis of rheumatoid arthritis (RA), had been recommended to start using a biologic or small molecule agent or to switch to a new one, and had Internet access. Access to ANSWER-2 was provided immediately after enrollment...
May 23, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28528967/chronic-fluoxetine-rescues-changes-in-plasma-membrane-density-of-5-ht1a-autoreceptors-and-serotonin-transporters-in-the-olfactory-bulbectomy-rodent-model-of-depression
#18
Mustapha Riad, Antonia Kobert, Laurent Descarries, Sandra Boye, Pierre-Paul Rompré, Jean-Claude Lacaille
Reduced serotonin (5-HT) neurotransmission is postulated to underlie the pathogenesis of depression. The serotonin transporter (SERT) and 5-HT1A auto-receptors act in concert to ensure homeostasis of serotonin (5-HT) neurotransmission and regulation of their cell surface expression represent efficient mechanisms to maintain this homeostasis. Thus, we investigated the changes in the subcellular distribution of SERT and 5-HT1A receptors (5-HT1AR) in the rat olfactory bulbectomy model of depression using immuno-gold labeling and electron microscopy, and examined the effect of chronic treatment with the antidepressant, fluoxetine, a serotonin reuptake inhibitor, on the subcellular distribution of SERT and 5-HT1AR...
July 25, 2017: Neuroscience
https://www.readbyqxmd.com/read/28510265/severity-and-outcome-of-the-norovirus-infection-in-children-after-intestinal-transplantation
#19
Marie Patte, Danielle Canioni, Véronique Avettand Fenoel, Pierre Frange, Marion Rabant, Cécile Talbotec, Florence Lacaille
In immunocompromised patients, the NoV infection is prolonged and severe. We retrospectively studied the severity of the NoV infection in children after an ITx, the treatment, and the long-term evolution. Norovirus PCR in stools was positive for 19 children in 21 separate episodes. The infection was symptomatic in 18 cases. At diagnosis, the median weight loss was 5% (0-11) and the creatinine clearance was 75 mL/min/1.73 m(2) (19-142). On 14 digestive biopsies, the pathological findings were non-specific with a constant mononuclear infiltration, showing signs of rejection in one case...
August 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28504725/metformin-ameliorates-core-deficits-in-a-mouse-model-of-fragile-x-syndrome
#20
Ilse Gantois, Arkady Khoutorsky, Jelena Popic, Argel Aguilar-Valles, Erika Freemantle, Ruifeng Cao, Vijendra Sharma, Tine Pooters, Anmol Nagpal, Agnieszka Skalecka, Vinh T Truong, Shane Wiebe, Isabelle A Groves, Seyed Mehdi Jafarnejad, Clément Chapat, Elizabeth A McCullagh, Karine Gamache, Karim Nader, Jean-Claude Lacaille, Christos G Gkogkas, Nahum Sonenberg
Fragile X syndrome (FXS) is the leading monogenic cause of autism spectrum disorders (ASD). Trinucleotide repeat expansions in FMR1 abolish FMRP expression, leading to hyperactivation of ERK and mTOR signaling upstream of mRNA translation. Here we show that metformin, the most widely used drug for type 2 diabetes, rescues core phenotypes in Fmr1(-/y) mice and selectively normalizes ERK signaling, eIF4E phosphorylation and the expression of MMP-9. Thus, metformin is a potential FXS therapeutic.
June 2017: Nature Medicine
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