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https://www.readbyqxmd.com/read/29690973/percutaneous-non-stenting-approach-for-distal-simultaneous-multivessel-acute-coronary-occlusions
#1
Muhammad Nasir Rahman, Bilal Hussain
The occurrence of distal coronary lesions causing simultaneous occlusion of two coronary arteries in the setting of ST elevation myocardial infarction is a rare occurrence. This can occur due to simultaneous plaque rupture at more than one site or embolisation in coronary arteries. We describe a case of a middle-aged man who presented with acute inferoposterior lateral wall ST elevation myocardial infarction with simultaneous occlusion of distal left anterior descending artery and distal left circumflex artery on angiogram...
May 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29690910/haemodynamic-outcomes-during-piston-based-mechanical-cpr-with-or-without-active-decompression-in-a-porcine-model-of-cardiac-arrest
#2
Mikkel T Steinberg, Jan-Aage Olsen, Morten Eriksen, Andres Neset, Per Andreas Norseng, Jo Kramer-Johansen, Bjarne Madsen Hardig, Lars Wik
BACKGROUND: Experimental active compression-decompression (ACD) CPR is associated with increased haemodynamic outcomes compared to standard mechanical chest compressions. Since no clinically available mechanical chest compression device is capable of ACD-CPR, we modified the LUCAS 2 (Physio-Control, Lund, Sweden) to deliver ACD-CPR, hypothesising it would improve haemodynamic outcomes compared with standard LUCAS CPR on pigs with cardiac arrest. METHODS: The modified LUCAS delivering 5 cm compressions with or without 2 cm active decompression above anatomical chest level was studied in a randomized crossover design on 19 Norwegian domestic pigs...
April 24, 2018: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/29689088/electrocardiogram-synchronized-pulsatile-extracorporeal-life-support-preserves-left-ventricular-function-and-coronary-flow-in-a-porcine-model-of-cardiogenic-shock
#3
Petr Ostadal, Mikulas Mlcek, Holger Gorhan, Ivo Simundic, Svitlana Strunina, Matej Hrachovina, Andreas Krüger, Dagmar Vondrakova, Marek Janotka, Pavel Hala, Martin Mates, Martin Ostadal, James C Leiter, Otomar Kittnar, Petr Neuzil
INTRODUCTION: Veno-arterial extracorporeal life support (ECLS) is increasingly being used to treat rapidly progressing or severe cardiogenic shock. However, it has been repeatedly shown that increased afterload associated with ECLS significantly diminishes left ventricular (LV) performance. The objective of the present study was to compare LV function and coronary flow during standard continuous-flow ECLS support and electrocardiogram (ECG)-synchronized pulsatile ECLS flow in a porcine model of cardiogenic shock...
2018: PloS One
https://www.readbyqxmd.com/read/29688195/preoperative-and-intraoperative-assessment-of-volumetric-blood-flow-velocity-through-the-internal-thoracic-artery-in-patients-with-cad
#4
V V Bazylev, F L Bartosh, S V Sivushchina, A I Mikuliak
The left internal thoracic artery (ITA) is currently an artery of choice for revascularization of coronary arteries. Ultrasonographic duplex scanning (USDS) and ultrasound Doppler flowmetry (UDF) are sequential techniques to control patency of the ITA at stages of rendering care for patients on restoring coronary blood flow. We compared two methods of measuring the volumetric blood flow velocity: by means of USDS and UDF. The obtained results were statistically processed. It was determined that transthoracic USDS and intraoperative UDF in the assessment of the volumetric blood velocity through the ITA in patients with coronary artery disease are comparable methods, provided the patients have similar parameters of central haemodynamics...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29688181/saline-induced-pd-pa-ratio-predicts-functional-significance-of-coronary-stenosis-assessed-using-fractional-flow-reserve
#5
Yoshiharu Fujimori, Tomoko Baba, Kyohei Yamazaki, Satoshi Hashimoto, Yasushi Yamanaka, Kenichiro Ebisuda, Kazuto Kurihara, Naoki Koike, Nao Takeuchi, Shigeru Nishiyama, Yuya Terasawa, Tadamasa Wakabayashi, Taku Imai
AIMS: Fractional flow reserve (FFR), assessed using distal coronary pressure/aortic pressure (Pd)/(Pa) ratio, functionally evaluates coronary stenosis. An assessment method without vasodilators would be helpful. A single intracoronary bolus of saline decreases Pd because of the speculated low-viscosity effect. We hypothesized that saline-induced Pd/Pa ratio (SPR) could functionally evaluate coronary stenosis. This study aimed to test the accuracy and utility of SPR for predicting FFR ≤0...
April 24, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29688179/comprehensive-physiological-evaluation-of-epicardial-and-microvascular-coronary-domains-using-vascular-conductance-and-zero-flow-pressure
#6
Nina W van der Hoeven, Guus A de Waard, Alicia Quirós, Alfonso De Hoyos, Christopher Broyd, Sukhjinder S Nijjer, Tim P van de Hoef, Ricardo Petraco, Roel S Driessen, Hernán Mejía-Rentería, Yuetsu Kikuta, Mauro Echavarría Pinto, Peter M van de Ven, Martijn Meuwissen, Paul Knaapen, Jan J Piek, Justin E Davies, Niels van Royen, Javier Escaned
AIMS: Assessment of the coronary circulation has largely been based on pressure ratios (epicardial-) and resistance (micro-vessels). Simultaneous assessment of epicardial- (CEPI) and microvascular conductance (CMICRO) provides an intuitive approach using the same units for both compartments and expressing the actual deliverability of blood. The aim of study was to develop a novel integral method to assessing the functional severity of epicardial and microvascular disease. METHODS AND RESULTS: We performed intracoronary Doppler and pressure in 403 vessels in 261 stable patients...
April 24, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29687877/the-mechanism-of-exogenous-adiponectin-in-the-prevention-of-no-reflow-phenomenon-in-type-2-diabetic-patients-with-acute-myocardial-infarction-during-pci-treatment
#7
C-J Zhang, Y-Z Deng, Y-H Lei, J-B Zhao, W Wei, Y-H Li
OBJECTIVE: To investigate the mechanism of exogenous adiponectin in the prevention of no-reflow phenomenon in type 2 diabetic (T2DM) patients with acute myocardial infarction (AMI) during percutaneous coronary intervention (PCI) treatment. PATIENTS AND METHODS: 66 patients were randomly divided into control group and observation group, 33 cases in each group. According to the percutaneous coronary intervention (PCI) emergency treatment principle, patients from the control group were treated with an intracoronary injection of adenosine combined with a micro-pump intravenous infusion of tirofiban...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29686030/left-ventricular-unloading-using-an-impella-cp-improves-coronary-flow-and-infarct-zone-perfusion-in-ischemic-heart-failure
#8
(no author information available yet)
No abstract text is available yet for this article.
April 23, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29685695/advanced-analyses-of-computed-tomography-coronary-angiography-can-help-discriminate-ischemic-lesions
#9
Jun-Mei Zhang, Dongsi Shuang, Lohendran Baskaran, Weijun Wu, Soo-Kng Teo, Weimin Huang, Like Gobeawan, John Carson Allen, Ru San Tan, Xi Su, Nasrul Bin Ismail, Min Wan, Boyang Su, Hua Zou, Ris Low, Xiaodan Zhao, Yanling Chi, Jiayin Zhou, Yi Su, Aileen Mae Lomarda, Chee Yang Chin, Jiang Ming Fam, Felix Yung Jih Keng, Aaron Sung Lung Wong, Jack Wei Chieh Tan, Khung Keong Yeo, Philip En Hou Wong, Chee Tang Chin, Kay Woon Ho, Jonathan Yap, Ghassan S Kassab, Terrance Chua, Tian Hai Koh, Swee Yaw Tan, Soo Teik Lim, Liang Zhong
BACKGROUND: Computed tomography coronary angiography (CTCA) image analysis enables plaque characterization and non-invasive fractional flow reserve (FFR) calculation. We analyzed various parameters derived from CTCA images and evaluated their associations with ischemia. METHODS: 49 (61 lesions) patients underwent CTCA and invasive FFR. Lesions with diameter stenosis (DS) ≥ 50% were considered obstructive. CTCA image processing incorporating analytical and numerical methods were used to quantify anatomical parameters of lesion length (LL) and minimum lumen area (MLA); plaque characteristic parameters of plaque volume, low attenuation plaque (LAP) volume, dense calcium volume (DCV), normalized plaque volume (NP Vol), plaque burden, eccentricity index and napkin-ring (NR) sign; and hemodynamic parameters of resistance index, stenosis flow reserve (SFR) and FFRB ...
April 20, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29685202/correlation-between-immunological-inflammatory-markers-and-endothelial-disfunction-in-the-early-stage-of-coronary-heart-disease
#10
Viktor Persic, Ana Lanca Bastiancic, Ivan Rosovic, Damir Raljevic, Dijana Travica Samsa, Luka Bastiancic, Rajko Miskulin, Marko Boban, Gordana Laskarin
Classical risk factors for endothelial dysfunction (ED), such as age, gender, total cholesterol, high-density lipoprotein cholesterol, systolic blood pressure, and smoking history are utilised for the Framingham score and Systemic Coronary Risk Estimation (SCORE) for evaluation of the 10-year cardiovascular risk in routine practice. Nonetheless, pro-inflammatory mediators are deeply involved in the initiation and the progression of ED and coronary artery disease (CAD), and act additionally or independently of metabolic factors before clinical manifestations of the disease appear...
June 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29684662/release-of-endothelial-microparticles-in-patients-with-arterial-hypertension-hypertensive-emergencies-and-catheter-related-injury
#11
Roberto Sansone, Maximilian Baaken, Patrick Horn, Dominik Schuler, Ralf Westenfeld, Nicolas Amabile, Malte Kelm, Christian Heiss
BACKGROUND AND AIMS: Circulating endothelial microparticles (EMPs) are increased in arterial hypertension. The role of physicomechanical factors that may induce EMP release in vivo is still unknown. We studied the relationship of EMPs and physicomechanical factors in stable arterial hypertension and hypertensive emergencies, and investigated the pattern of EMP release after mechanical endothelial injury. METHODS: In a pilot study, 41 subjects (50% hypertensives) were recruited...
April 12, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29683558/simplified-hybrid-algorithms-for-pressure-wire-interrogation-exploiting-advantages-of-a-baseline-and-contrast-pd-pa-ratio-indexes-to-predict-stenosis-significance-insight-from-the-spare-multicenter-prospective-study
#12
E Cerrato, F Tomassini, P Salinas, M Pavani, F Conrotto, M Echavarria-Pinto, F Macaya, G Quadri, F D'Ascenzo, Alicia Quirós, F Varbella, J Escaned
BACKGROUND: Simplification of functional stenosis assessment with pressure guidewires may facilitate adoption of physiology-guided revascularization. An important step in this regard is the avoidance of hyperemic agents, required for fractional flow reserve (FFR) calculation. We evaluate the merits of a hybrid algorithms that combines the translesional pressure ratio (Pd/Pa) obtained at rest, after contrast medium injection (cFFR) and after adenosine administration (FFR). METHODS AND RESULTS: Eighty-six patients with 108 de novo intermediate coronary stenoses were included in this prospective, multicenter study...
April 23, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29682509/initiation-and-propagation-of-vascular-calcification-is-regulated-by-a-concert-of-platelet-and-smooth-muscle-cell-derived-extracellular-vesicles
#13
Leon J Schurgers, Asim C Akbulut, Dawid M Kaczor, Maurice Halder, Rory R Koenen, Rafael Kramann
The ageing population continues to suffer from its primary killer, cardiovascular disease (CVD). Despite recent advances in interventional medicinal and surgical therapies towards the end of the 20th century, the epidemic of cardiovascular disease has not been halted. Yet, rather than receding globally, the burden of CVD has risen to become a top cause of morbidity and mortality worldwide. Most CVD arises from thrombotic rupture of an atherosclerotic plaque, the pathologic thickening of coronary and carotid artery segments and subsequent distal ischemia in heart or brain...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29681850/-tnfrsf12a-mediated-atherosclerosis-signaling-and-inflammatory-response-as-a-common-protection-mechanism-of-shuxuening-injection-against-both-myocardial-and-cerebral-ischemia-reperfusion-injuries
#14
Ming Lyu, Ying Cui, Tiechan Zhao, Zhaochen Ning, Jie Ren, Xingpiao Jin, Guanwei Fan, Yan Zhu
Shuxuening injection (SXNI) is a widely prescribed herbal medicine of Ginkgo biloba extract (EGB) for cerebral and cardiovascular diseases in China. However, its curative effects on ischemic stroke and heart diseases and the underlying mechanisms remain unknown. Taking an integrated approach of RNA-seq and network pharmacology analysis, we compared transcriptome profiles of brain and heart ischemia reperfusion injury in C57BL/6J mice to identify common and differential target genes by SXNI. Models for myocardial ischemia reperfusion injury (MIRI) by ligating left anterior descending coronary artery (LAD) for 30 min ischemia and 24 h reperfusion and cerebral ischemia reperfusion injury (CIRI) by middle cerebral artery occlusion (MCAO) for 90 min ischemia and 24 h reperfusion were employed to identify the common mechanisms of SXNI on both cerebral and myocardial ischemia reperfusion...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29681575/sinus-standstill-in-a-patient-after-intracoronary-papaverine-administration-for-a-coronary-fractional-flow-reserve
#15
Masahiro Nauchi, Tsuyoshi Sakai, Masahiro Yamawaki, Yoshiaki Ito
A 78-year-old woman had paroxysmal atrial fibrillation and effort angina. Two months before she was admitted for a coronary angiography, she had been feeling dizzy. A Holter 24-hour electrocardiography monitor exhibited an asymptomatic episode of 2.9 seconds of RR interval. She underwent a coronary angiography, which showed intermediate stenosis in the left descending artery. Fractional flow reserve (FFR) measurement using intracoronary papaverine administration was performed. After intracoronary papaverine (12 mg) administration, pause of 4 seconds led to polymorphic ventricular tachycardia (VT), although the VT terminated spontaneously...
April 20, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29681566/off-pump-coronary-artery-bypass-grafting-with-mini-sternotomy-in-the-treatment-of-triple-vessel-coronary-artery-disease
#16
Pixiong Su, Song Gu, Yan Liu, Xitao Zhang, Jun Yan, Xiangguang An, Jie Gao, Yue Xin, Jian Zhou
We have developed off-pump coronary artery bypass approach with lower distal mini-sternotomy (TM-OPCAB) for multivessel coronary revascularization. The aim of this retrospective study is to provide evidence for the feasibility and safety of this technique in the treatment of triple-vessel diseases.Two hundred eighty-eight patients with triple-vessel coronary artery disease who underwent TM-OPCAB or standard off-pump coronary artery bypass surgery (S-OPCAB) were included in this study after propensity-score matching...
April 20, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29681368/outcomes-after-balloon-pulmonary-valvuloplasty-for-critical-pulmonary-stenosis-and-incidence-of-coronary-artery-fistulas
#17
Varun Aggarwal, Venkatachalam Mulukutla, Shiraz Maskatia, Henri Justino, Charles E Mullins, Athar M Qureshi
Outcome data for neonates with critical pulmonary stenosis (PS) is limited. We aimed to review the outcomes after balloon pulmonary valvuloplasty (BPV) for neonates with critical PS at our institution. All neonates with critical PS who underwent BPV from 1990 to 2017 were included. A total of 44 neonates underwent BPV for critical PS. Nonright ventricular dependent coronary artery fistulas was seen in 6/44 (13.6%) patients. Tricuspid valve z-scores were -1.9 (interquartile range [IQR] -3.04, -0.48) in those with coronary artery fistulas as compared with -0...
March 13, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29680298/experimental-evaluation-of-homemade-distal-stent-graft-fenestration-for-thoracic-endovascular-aortic-repair-of-type-a-dissection-by-a-transapical-approach
#18
Thomas Gandet, Anis Seghrouchni, Baris Ata Ozdemir, Guillaume Captier, Roland Demaria, Pierre Alric, Bernard Albat, Ludovic Canaud
OBJECTIVE: The use of off-the-shelf stent grafts for thoracic endovascular aortic repair of type A dissections is limited by variability in both the length of the ascending aorta and the location of the proximal intimal tear. This experimental study aimed to assess the feasibility of using a physician-modified thoracic aortic stent graft to treat acute type A dissection by a transapical cardiac approach. METHODS: The experiments were performed on six cadaveric human heart, ascending aorta, aortic arch, and descending aorta specimens...
April 18, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29679191/myocardial-flow-reserve-derived-by-dynamic-perfusion-single-photon-emission-computed-tomography-reflects-the-severity-of-coronary-atherosclerosis
#19
Nobuo Iguchi, Yuko Utanohara, Yasuhiro Suzuki, Makoto Suzuki, Kenichi Hagiya, Ryosuke Higuchi, Itaru Takamisawa, Tetsuya Tobaru, Tetsuya Sumiyoshi, Mitsuaki Isobe
A novel single-photon emission computed tomography (SPECT) camera was developed to evaluate dynamic myocardial perfusion flow. However, it is unclear whether myocardial flow reserve (MFR) derived by dynamic perfusion SPECT using the novel SPECT camera (D-SPECT) reflects the severity of coronary atherosclerosis. In the present study, we therefore examined the relationship between MFR using D-SPECT and severity of coronary lesions. The study population comprised 40 patients who underwent both a myocardial dynamic perfusion SPECT study and invasive coronary angiography...
April 20, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29674972/gualou-xiebai-decoction-a-traditional-chinese-medicine-prevents-cardiac-reperfusion-injury-of-hyperlipidemia-rat-via-energy-modulation
#20
Lu-Lu Yan, Wei-Yang Zhang, Xiao-Hong Wei, Li Yan, Chun-Shui Pan, Yang Yu, Jing-Yu Fan, Yu-Ying Liu, Hua Zhou, Jing-Yan Han, Xin-Sheng Yao
Background: Gualou Xiebai Decoction (GLXB) is a classic prescription of Chinese medicine used for the treatment of cardiac problems. The present study was designed to explore the effect and mechanism of GLXB on ischemia/reperfusion (I/R) induced disorders in myocardial structure and function, focusing on the regulation of energy metabolism and the RhoA/ROCK pathway. Methods: After hyperlipidemic rat model was established by oral administration of high fat diet, the rats were treated with GLXB for 6 weeks and subjected to 30 min occlusion of the left anterior descending coronary artery (LADCA) followed by 90 min reperfusion to elicit I/R challenge...
2018: Frontiers in Physiology
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