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https://www.readbyqxmd.com/read/28926310/coronary-ct-angiography-derived-fractional-flow-reserve
#1
Christian Tesche, Carlo N De Cecco, Moritz H Albrecht, Taylor M Duguay, Richard R Bayer, Sheldon E Litwin, Daniel H Steinberg, U Joseph Schoepf
Invasive coronary angiography (ICA) with measurement of fractional flow reserve (FFR) by means of a pressure wire technique is the established reference standard for the functional assessment of coronary artery disease (CAD) ( 1 , 2 ). Coronary computed tomographic (CT) angiography has emerged as a noninvasive method for direct assessment of CAD and plaque characterization with high diagnostic accuracy compared with ICA ( 3 , 4 ). However, the solely anatomic assessment provided with both coronary CT angiography and ICA has poor discriminatory power for ischemia-inducing lesions...
October 2017: Radiology
https://www.readbyqxmd.com/read/28925922/fabricating-tio2-nanocolloids-by-electric-spark-discharge-method-at-normal-temperature-and-pressure
#2
Kuo-Hsiung Tseng, Chaur-Yang Chang, Meng-Yun Chung, Ting-Shou Cheng
In this study, TiO2 nanocolloids were successfully fabricated in deionized water without using suspending agents through using the electric spark discharge method at room temperature and under normal atmospheric pressure. This method was exceptional because it did not create nanoparticle dispersion and the produced colloids contained no derivatives. The proposed method requires only traditional electrical discharge machines (EDMs), self-made magnetic stirrers, and Ti wires (purity, 99.99%). The EDM pulse on time (Ton) and pulse off Time (Toff) were respectively set at 50 and 100 s, 100 and 100 s, 150 and 100 s, and 200 and 100 s to produce four types of TiO2 nanocolloids...
September 19, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28914129/maternal-high-fat-diet-programs-cerebrovascular-remodeling-in-adult-rat-offspring
#3
ChengCheng Lin, XiaoYun Wu, YuLei Zhou, Bei Shao, XiaoTing Niu, WanLi Zhang, YuanShao Lin
Maternal environmental factors such as diet have consequences on later health of the offspring. We found that maternal high-fat diet (HFD) exposure renders adult offspring brain more susceptible to ischemic injury. The present study was further to investigate whether HFD consumption during rat pregnancy and lactation influences the cerebral vasculature in adult male offspring. Besides the endothelial damage observed in the transmission electron microscopy, the MCAs of offspring from fat-fed dams fed with control diet (HFD/C) also displayed increased wall thickness and media/lumen ratio, suggesting that cerebrovascular hypertrophy or hyperplasia occurs...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28902523/functional-assessment-of-lesion-severity-without-using-the-pressure-wire-coronary-imaging-and-blood-flow-simulation
#4
Michail I Papafaklis, Michail C Mavrogiannis, Panagiotis K Siogkas, Lampros S Lakkas, Christos S Katsouras, Dimitrios I Fotiadis, Lampros K Michalis
Hemodynamic indices derived from measurements with the pressure wire (primarily fractional flow reserve [FFR]) have been established as a reliable tool for assessing coronary stenoses and improving clinical decision making. However, the use of the pressure wire constitutes a hurdle for the universal adoption of physiology-guided patient management. Technological advancements have enabled the large-scale application of blood flow simulation (computational fluid dynamics [CFD]) to medical imaging, thereby enabling the virtual assessment of coronary physiology...
September 19, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28889277/neurodegeneration-induced-by-metals-in-caenorhabditis-elegans
#5
Felix Antunes Soares, Daiandra Almeida Fagundez, Daiana Silva Avila
Metals are a component of a variety of ecosystems and organisms. They can generally be divided into essential and nonessential metals. The essential metals are involved in physiological processes once the deficiency of these metals has been associated with diseases. Although iron, manganese, copper, and zinc are important for life, it has been evidenced that they are also involved in neuronal damage in many neurodegenerative disorders. Nonessential metals, which are metals without physiological functions, are present in trace or higher levels in living organisms...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28878102/coronary-intervention-complicated-by-pressure-wires-caught-within-stent-struts
#6
Ozan M Demir, Neil Ruparelia, Masood Khan, Christopher Baker
Coronary guidewire fracture or entrapment is a recognized complication of percutaneous coronary intervention that can result in abrupt vessel closure, thrombosis, or stent deformation. Developments in pressure-wire (PW) design have enabled their use for coronary intervention. We describe two cases where the pressure sensor became trapped against stent struts during PW removal.
September 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28853190/diagnostic-accuracy-of-instantaneous-wave-free-ratio-in-clinical-practice
#7
Wern Yew Ding, Satheesh Nair, Clare Appleby
AIMS: To evaluate the correlation between iFR and FFR in real-world clinical practice. METHODS AND RESULTS: Retrospective, single-centre study of 229 consecutive pressure-wire studies (np  = 158). Real-time iFR and FFR measurements were performed for angiographically borderline stenoses. Functionally significant stenoses were defined as iFR <0.86 or FFR ≤0.80. An iFR between 0.86 and 0.93 was considered within the grey zone (Hybrid approach). Median iFR and FFR (IQR) were 0...
August 29, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/28844029/state-of-the-art-pressure-wire-and-coronary-functional-assessment
#8
Mauro Echavarría-Pinto, Carlos Collet, Javier Escaned, Jan J Piek, Patrick W Serruys
The pressure wire has revolutionised cardiology by moving the focus of revascularisation from anatomy to physiology. This review provides a comprehensive viewpoint on the foundations of the field of intracoronary physiology, with emphasis on the development and clinical evidence of fractional flow reserve (FFR). Additionally, we critically appraise clinical decision making based on the evolving area of resting coronary physiology. The emerging role of coronary flow reserve and its complementariness with FFR is also discussed, and the importance of the invasive assessment of the coronary microcirculation in outlining prognosis is put into perspective...
August 25, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28835858/case-report-of-first-angiography-based-on-line-ffr-assessment-during-coronary-catheterization
#9
Ran Kornowski, Hana Vaknin-Assa
Fractional flow reserve (FFR), an index of the hemodynamic severity of coronary stenoses, is derived from hyperemic pressure measurements and requires a pressure-monitoring guide wire and hyperemic stimulus. Although it has become the standard of reference for decision-making regarding coronary revascularization, the procedure remains underutilized due to its invasive nature. FFRangio is a novel technology that uses the patient's hemodynamic data and routine angiograms to generate a complete three-dimensional coronary tree, with color-coded display of the FFR values at each point along the vessels...
2017: Case Reports in Cardiology
https://www.readbyqxmd.com/read/28833444/energy-efficient-neural-information-processing-in-individual-neurons-and-neuronal-networks
#10
REVIEW
Lianchun Yu, Yuguo Yu
Brains are composed of networks of an enormous number of neurons interconnected with synapses. Neural information is carried by the electrical signals within neurons and the chemical signals among neurons. Generating these electrical and chemical signals is metabolically expensive. The fundamental issue raised here is whether brains have evolved efficient ways of developing an energy-efficient neural code from the molecular level to the circuit level. Here, we summarize the factors and biophysical mechanisms that could contribute to the energy-efficient neural code for processing input signals...
August 22, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28829743/intracoronary-electrocardiogram-to-guide-percutaneous-interventions-in-coronary-bifurcations-a-proof-of-concept-the-fiesta-ffr-vs-icecgsta-study
#11
Dobrin Vassilev, Liubomir Dosev, Carlos Collet, Kiril Karamfiloff, Jivka Stoikova, Ralica Pancheva, Monika Shumkova, Galina Zlatancheva, Vladimir Naunov, Gianluca Rigatelli, Ghassan S Kassab, Robert J Gil, Patrick W Serruys
AIMS: The aim of this study was to determine the accuracy of the intracoronary electrocardiogram (icECG) to detect ischemia during bifurcation lesions percutaneous coronary intervention (PCI) with fractional flow reserve (FFR) as a reference. METHODS AND RESULTS: Patients with significant bifurcation lesions defined as FFR≤0.80 were included. FFR and icECG were performed in the main vessel (MV) and side branch (SB) before and after provisional stenting. icECG was recorded with a uninsulated proximal wire end connected to a unipolar lead...
August 22, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28810262/fetal-sheep-mesenteric-resistance-arteries-functional-and-structural-maturation
#12
Julia J Müller, Matthias Schwab, Charles R Rosenfeld, Iwa Antonow-Schlorke, Peter W Nathanielsz, Florian Rakers, Harald Schubert, Otto W Witte, Sven Rupprecht
BACKGROUND: Fetal blood pressure increases during late gestation; however, the underlying vascular mechanisms are unclear. Knowledge of the maturation of resistance arteries is important to identify the mechanisms and vulnerable periods for the development of vascular dysfunction in adulthood. METHODS: We determined the functional and structural development of fetal sheep mesenteric resistance arteries using wire myography and immunohistochemistry. RESULTS: Media mass and distribution of myosin heavy-chain isoforms showed no changes between 0...
August 16, 2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28804057/pressure-wire-versus-microcatheter-for-ffr-measurement-a-head-to-head-comparison
#13
Christophe Pouillot, Stéphane Fournier, Jens Glasenapp, Goeffray Rambaud, Karim Bougrini, Richard Vi Fane, Christophe Geyer, Julien Adjedj
AIMS: Recently developed microcatheters can be used instead of pressure wire for fractional flow reserve (FFR) measurement. We sought to assess the hemodynamic and clinical impacts of using larger profile device to measure FFR. METHODS AND RESULTS: Our prospective registry included 99 consecutive patients who underwent invasive FFR measurements of intermediate coronary stenoses between June 2015 and July 2016. FFR values were obtained first using a pressure wire only (FFRw), second using a Navvus microcatheter (FFRmc), and finally using the wire with the microcatheter still in the stenosis (FFRw-mc) during intravenous adenosine infusion...
August 15, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28796998/microrna-dependent-control-of-serotonin-induced-pulmonary-arterial-contraction
#14
Diana Dahan, Tran Thi Hien, Philip Tannenberg, Mari Ekman, Catarina Rippe, Thomas Boettger, Thomas Braun, Karin Tran-Lundmark, Phan-Kiet Tran, Karl Swärd, Sebastian Albinsson
BACKGROUND: Serotonin (5-HT) is considered to play a role in pulmonary arterial hypertension by regulating vascular remodeling and smooth muscle contractility. Here, arteries from mice with inducible and smooth muscle-specific deletion of Dicer were used to address mechanisms by which microRNAs control 5-HT-induced contraction. METHODS: Mice were used 5 weeks after Dicer deletion, and pulmonary artery contractility was analyzed by wire myography. RESULTS: No change was seen in right ventricular systolic pressure following dicer deletion, but systemic blood pressure was reduced...
2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28780839/-feasibility-and-value-of-index-of-microcirculatory-resistance-in-patients-with-acute-myocardial-infarction-after-primary-percutaneous-coronary-intervention
#15
J L Han, L Y He, M Cui, Y Z Zhang, X B Liu, X Y Xu, Y P Wang, F F Wang, G S Wang, J Niu, F C Zhang, L Mi, L J Guo, W Gao
Objective: To evaluate the feasibility of detecting index of microcirculatory resistance (IMR) and the relationship between IMR and left ventricular (LV) systolic function after acute myocardial infarction (AMI) undergoing primary percutaneous coronary intervention (PCI). Methods: The patients with first AMI received primary PCI in Peking University Third Hospital were enrolled from January 2014 to March 2016. IMR were measured immediately after PCI by using pressure/temperature wire. The relationship between IMR and left ventricular ejection fraction (LVEF) assessed by echocardiography at first day and 6 months after admission was evaluated...
August 1, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28767221/diffusion-bonding-of-metal-wires-directly-to-the-functional-metal-oxide-semiconductors-for-forming-reliable-electrical-contacts
#16
Faramarz Hossein-Babaei, Mohsen Gharesi, Maryam Moalaghi
Forming reliable ohmic contacts to the functional metal oxide semiconductors has always been problematic in fabricating sensors and actuators. The common practice is to establish wire bonds to the metallic films previously deposited/printed over or under the oxide layer. Here, we describe a method for the diffusion bonding of metallic wire segments directly to the oxide layer surface, and demonstrate the reproducible formation of contacts with reliable mechanical and electrical qualities. Bonding is made at elevated temperatures in the 350-500 °C range under die pressure...
August 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28766865/trapping-as-retrieval-technique-to-resolve-a-ruptured-and-entrapped-coronary-balloon-catheter
#17
Javier León Jiménez, Jessica Roa Garrido, Santiago Jesús Camacho Freire, José Francisco Díaz Fernández
A 69 year old male, with a previous percutaneous revascularization of the mid-circumflex with a bare metal stent in 2007 was admitted to our centre for unstable angina. The angiography showed a severely calcified coronary tree with a functionally severe plaque on the proximal left anterior descending artery (LAD) and a critical focal lesion on the proximal right coronary artery. After a high pressure predilation on the proximal LAD, the balloon ruptured causing a retrograde LAD-left main (LM) dissection that was rapidly sealed with three overlapping zotarolimus-eluting stents from medial LAD to LM...
August 2, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28760938/vasorelaxation-to-the-nitroxyl-donor-isopropylamine-nonoate-in-resistance-arteries-does-not-require-perivascular-calcitonin-gene-related-peptide
#18
Alice M H Pinkney, Hamish A L Lemmey, Kim A Dora, Christopher J Garland
Nitroxyl (HNO) donors offer considerable therapeutic potential for the treatment of hypertension-related cardiovascular disorders, particularly heart failure, as they combine an inotropic action with peripheral vasodilation. Angeli's salt is the only HNO donor whose mechanism has been studied in depth, and recently, Angeli's salt vasodilation was suggested to be indirect and caused by calcitonin gene-related peptide (CGRP) released from perivascular nerves after HNO activates TRPA1 (transient receptor potential cation channel subfamily A member 1) channels...
July 31, 2017: Hypertension
https://www.readbyqxmd.com/read/28754566/impact-of-asymmetric-dimethylarginine-on-coronary-physiology-early-after-heart-transplantation
#19
RANDOMIZED CONTROLLED TRIAL
Rushi V Parikh, Kiran K Khush, Helen Luikart, Vedant S Pargaonkar, Yuhei Kobayashi, Jang Hoon Lee, Seema Sinha, Garrett Cohen, Hannah A Valantine, Alan C Yeung, William F Fearon
Cardiac allograft vasculopathy is a major cause of long-term graft failure following heart transplantation. Asymmetric dimethylarginine (ADMA), a marker of endothelial dysfunction, has been mechanistically implicated in the development of cardiac allograft vasculopathy, but its impact on coronary physiology early after transplantation is unknown. Invasive indices of coronary physiology, namely, fractional flow reserve (FFR), the index of microcirculatory resistance, and coronary flow reserve, were measured with a coronary pressure wire in the left anterior descending artery within 8 weeks (baseline) and 1 year after transplant...
September 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28738007/comparison-of-intraosseous-pentobarbital-administration-and-thoracic-compression-for-euthanasia-of-anesthetized-sparrows-passer-domesticus-and-starlings-sturnus-vulgaris
#20
Joanne R Paul-Murphy, Andrew Engilis, Peter J Pascoe, D Colette Williams, Kate A Gustavsen, Tracy L Drazenovich, M Kevin Keel, Tamsen M Polley, Irene E Engilis
OBJECTIVE To compare intraosseous pentobarbital treatment (IPT) and thoracic compression (TC) on time to circulatory arrest and an isoelectric electroencephalogram (EEG) in anesthetized passerine birds. ANIMALS 30 wild-caught adult birds (17 house sparrows [Passer domesticus] and 13 European starlings [Sturnus vulgaris]). PROCEDURES Birds were assigned to receive IPT or TC (n = 6/species/group). Birds were anesthetized, and carotid arterial pulses were monitored by Doppler methodology. Five subdermal braided-wire electrodes were used for EEG...
August 2017: American Journal of Veterinary Research
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