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https://www.readbyqxmd.com/read/29784630/what-are-the-causes-of-a-suboptimal-ffr-after-coronary-stent-deployment-insights-from-a-consecutive-series-using-oct-imaging
#1
Mathias Wolfrum, Giovanni Luigi De Maria, Stefano Benenati, Jeremy Langrish, Andrew J Lucking, Keith M Channon, Rajesh K Kharbanda, Adrian P Banning
AIMS: Fractional flow reserve (FFR) can be used to detect a suboptimal result after percutaneous coronary intervention (PCI). A lower post procedure FFR (< 0.90) has been shown to be associated with adverse clinical outcomes at follow-up. This pilot study aimed to understand the mechanisms resulting in a suboptimal FFR and whether Optical Coherence Tomography (OCT) guided optimisation could improve final FFR. METHODS AND RESULTS: Thirty five patients undergoing complex PCI were prospectively enrolled...
May 21, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29769168/pressure-wire-compared-to-microcatheter-sensing-for-coronary-fractional-flow-reserve-the-perform-study
#2
Ziad A Ali, Yasir Parviz, Matthew Brinkman, Mitsuaki Matsumura, Björn Redfors, David A Brogno, Maria D Corral, Khady N Fall, Gary S Mintz, Gregg W Stone, Akiko Maehara, Allen Jeremias, Ajay J Kirtane
AIMS: Among technologies used to assess FFR, a monorail, sensor-tipped micro pressure catheter (PC) may be advantageous for delivery and re-assessment. We sought to determine whether the larger cross-sectional area of the PC influences FFR measurements compared to the pressure wire. METHODS AND RESULTS: PERFORM was a single-center, prospective study designed to determine the precision and accuracy of the PC compared with the pressure wire (PW) for measurement of FFR...
May 15, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29693560/self-catalyzed-cdte-wires
#3
Tom Baines, Giorgos Papageorgiou, Oliver S Hutter, Leon Bowen, Ken Durose, Jonathan D Major
CdTe wires have been fabricated via a catalyst free method using the industrially scalable physical vapor deposition technique close space sublimation. Wire growth was shown to be highly dependent on surface roughness and deposition pressure, with only low roughness surfaces being capable of producing wires. Growth of wires is highly (111) oriented and is inferred to occur via a vapor-solid-solid growth mechanism, wherein a CdTe seed particle acts to template the growth. Such seed particles are visible as wire caps and have been characterized via energy dispersive X-ray analysis to establish they are single phase CdTe, hence validating the self-catalysation route...
April 25, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29691307/effects-of-anterior-compartment-fasciotomy-on-intramuscular-compartment-pressure-in-patients-with-chronic-exertional-compartment-syndrome
#4
David Roscoe, A J Roberts, D Hulse, A F Shaheen, M P Hughes, A N Bennet
BACKGROUND: Patients with chronic exertional compartment syndrome (CECS) have pain during exercise that usually subsides at rest. Diagnosis is usually confirmed by measurement of intramuscular compartment pressure (IMCP) following exclusion of other possible causes. Management usually requires fasciotomy but reported outcomes vary widely. There is little evidence of the effectiveness of fasciotomy on IMCP. Testing is rarely repeated postoperatively and reported follow-up is poor. Improved diagnostic criteria based on preselection and IMCP levels during dynamic exercise testing have recently been reported...
April 24, 2018: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/29689088/electrocardiogram-synchronized-pulsatile-extracorporeal-life-support-preserves-left-ventricular-function-and-coronary-flow-in-a-porcine-model-of-cardiogenic-shock
#5
Petr Ostadal, Mikulas Mlcek, Holger Gorhan, Ivo Simundic, Svitlana Strunina, Matej Hrachovina, Andreas Krüger, Dagmar Vondrakova, Marek Janotka, Pavel Hala, Martin Mates, Martin Ostadal, James C Leiter, Otomar Kittnar, Petr Neuzil
INTRODUCTION: Veno-arterial extracorporeal life support (ECLS) is increasingly being used to treat rapidly progressing or severe cardiogenic shock. However, it has been repeatedly shown that increased afterload associated with ECLS significantly diminishes left ventricular (LV) performance. The objective of the present study was to compare LV function and coronary flow during standard continuous-flow ECLS support and electrocardiogram (ECG)-synchronized pulsatile ECLS flow in a porcine model of cardiogenic shock...
2018: PloS One
https://www.readbyqxmd.com/read/29683558/simplified-hybrid-algorithms-for-pressure-wire-interrogation-exploiting-advantages-of-a-baseline-and-contrast-pd-pa-ratio-indexes-to-predict-stenosis-significance-insight-from-the-spare-multicenter-prospective-study
#6
E Cerrato, F Tomassini, P Salinas, M Pavani, F Conrotto, M Echavarria-Pinto, F Macaya, G Quadri, F D'Ascenzo, Alicia Quirós, F Varbella, J Escaned
BACKGROUND: Simplification of functional stenosis assessment with pressure guidewires may facilitate adoption of physiology-guided revascularization. An important step in this regard is the avoidance of hyperemic agents, required for fractional flow reserve (FFR) calculation. We evaluate the merits of a hybrid algorithms that combines the translesional pressure ratio (Pd/Pa) obtained at rest, after contrast medium injection (cFFR) and after adenosine administration (FFR). METHODS AND RESULTS: Eighty-six patients with 108 de novo intermediate coronary stenoses were included in this prospective, multicenter study...
April 23, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29671348/four-strand-versus-2-strand-suture-button-constructs-in-first-carpometacarpal-arthroplasty-a-biomechanical-study
#7
Beatrice L Grasu, Andrew J Trontis, Brent G Parks, Raymond A Wittstadt
BACKGROUND: Suture-button fixation is an alternative to no fixation, first metacarpal distraction techniques, or Kirschner wire fixation after trapeziectomy in treatment of first carpometacarpal (CMC) arthritis. A 4-strand suture-button construct requires a 2.7-mm tunnel, whereas a 2-strand construct requires a 1.1-mm tunnel, potentially decreasing the risk of metacarpal fracture. We compared stability and failure criteria of 4-strand versus 2-strand construct in a biomechanical model of first CMC joint arthroplasty...
April 1, 2018: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/29643128/effects-of-impella-on-coronary-perfusion-in-patients-with-critical-coronary-artery-stenosis
#8
Mohammad Alqarqaz, Mir Basir, Khaldoon Alaswad, William O'Neill
BACKGROUND: Mechanical circulatory support devices are used to maintain hemodynamic stability during high-risk percutaneous coronary interventions. Little is known on the effects of such devices on coronary hemodynamics in patients with significant coronary stenosis. We sought to investigate whether mechanical circulatory support in the form of Impella (Abiomed Inc, Danvers, MA) can improve coronary hemodynamics in the presence of a critical coronary stenosis. METHODS AND RESULTS: We examined coronary perfusion pressures and coronary pressure distal to a critical stenosis using a coronary pressure wire in 11 patients (12 coronary lesions) undergoing high-risk percutaneous coronary interventions with the use of mechanical circulatory support...
April 2018: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29627954/hemodynamic-comparison-of-different-multisites-and-multipoint-pacing-strategies-in-cardiac-resynchronization-therapies
#9
Francesco Zanon, Lina Marcantoni, Enrico Baracca, Gianni Pastore, Giuseppina Giau, Gianluca Rigatelli, Daniela Lanza, Claudio Picariello, Silvio Aggio, Sara Giatti, Marco Zuin, Loris Roncon, Domenico Pacetta, Franco Noventa, Frits W Prinzen
PURPOSE: In order to increase the responder rate to CRT, stimulation of the left ventricular (LV) from multiple sites has been suggested as a promising alternative to standard biventricular pacing (BIV). The aim of the study was to compare, in a group of candidates for CRT, the effects of different pacing configurations-BIV, triple ventricular (TRIV) by means of two LV leads, multipoint (MPP), and multipoint plus a second LV lead (MPP + TRIV) pacing-on both hemodynamics and QRS duration...
April 7, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/29627179/a-prostacyclin-agonist-and-an-omental-flap-increased-myocardial-blood-flow-in-a-porcine-chronic-ischemia-model
#10
Shin Yajima, Shigeru Miyagawa, Satsuki Fukushima, Yoshiki Sakai, Kayako Isohashi, Tadashi Watabe, Hayato Ikeda, Genki Horitsugi, Akima Harada, Ryoto Sakaniwa, Jun Hatazawa, Yoshiki Sawa
OBJECTIVE: We hypothesized that therapeutic efficacy may be augmented by a combination of placing a sheet immersed in ONO-1301SR, a slow-release synthetic prostacyclin agonist-inducing multiproangiogenic cytokines, over the left ventricle and a pedicled omental flap in a chronic myocardial infarct heart. METHODS: A minipig chronic myocardial infarction was generated by placing an ameroid constrictor ring around the left anterior descending artery for 4 weeks. The minipigs were then assigned into 4 groups of 6 each: sham, omental flap only, ONO-1301SR only, and ONO-1301SR combined with an omental flap (combined)...
March 11, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29623045/relaxin-deficiency-leads-to-uterine-artery-dysfunction-during-pregnancy-in-mice
#11
Sarah A Marshall, Sevvandi N Senadheera, Maria Jelinic, Kelly O'Sullivan, Laura J Parry, Marianne Tare
The uterine vasculature undergoes profound adaptations in response to pregnancy. Augmentation of endothelial vasodilator function and reduced smooth muscle reactivity are factors contributing to uterine artery adaptation and are critical for adequate placental perfusion. The peptide hormone relaxin has an important role in mediating the normal maternal renal vascular adaptations during pregnancy through a reduction in myogenic tone and an increase in flow-mediated vasodilation. Little is known however about the influence of endogenous relaxin on the uterine artery during pregnancy...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29617762/pressure-gradient-vs-flow-relationships-to-characterize-the-physiology-of-a-severely-stenotic-aortic-valve-before-and-after-transcatheter-valve-implantation
#12
Nils P Johnson, Jo M Zelis, Pim A L Tonino, Patrick Houthuizen, R Arthur Bouwman, Guus R G Brueren, Daniel T Johnson, Jacques J Koolen, Hendrikus H M Korsten, Inge F Wijnbergen, Frederik M Zimmermann, Richard L Kirkeeide, Nico H J Pijls, K Lance Gould
Aims: Echocardiography and tomographic imaging have documented dynamic changes in aortic stenosis (AS) geometry and severity during both the cardiac cycle and stress-induced increases in cardiac output. However, corresponding pressure gradient vs. flow relationships have not been described. Methods and results: We recruited 16 routine transcatheter aortic valve implantations (TAVI's) for graded dobutamine infusions both before and after implantation; 0.014″ pressure wires in the aorta and left ventricle (LV) continuously measured the transvalvular pressure gradient (ΔP) while a pulmonary artery catheter regularly assessed cardiac output by thermodilution...
April 2, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29616628/pressure-wire-assessment-of-jailed-balloon-technique-efficacy-in-a-patient-with-complex-bifurcated-lesion
#13
Hiroyuki Omori, Yoshiaki Kawase, Toru Tanigaki, Hitoshi Matsuo
No abstract text is available yet for this article.
April 3, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29605243/diagnostic-and-prognostic-efficacy-of-coronary-flow-capacity-obtained-using-pressure-temperature-sensor-tipped-wire-derived-physiological-indices
#14
Rikuta Hamaya, Taishi Yonetsu, Yoshihisa Kanaji, Eisuke Usui, Masahiro Hoshino, Masao Yamaguchi, Masahiro Hada, Yoshinori Kanno, Tadashi Murai, Kenzo Hirao, Tsunekazu Kakuta
OBJECTIVES: This study aimed to evaluate the feasibility and efficacy of pressure-temperature sensor-tipped wire-derived coronary flow capacity (PTW-CFC) for assessing flow impairment and prognosis. BACKGROUND: CFC provides an integrated coronary physiological assessment in which coronary flow reserve and coronary flow during hyperemia are organized. METHODS: A total of 643 native de novo lesions for which physiological assessments were performed using a PressureWire (St...
March 23, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29604784/an-ionization-pressure-gauge-with-lab-6-emitter-for-long-term-operation-in-strong-magnetic-fields
#15
U Wenzel, T S Pedersen, M Marquardt, M Singer
We report here on a potentially significant improvement in the design of neutral pressure gauges of the so-called ASDEX-type which were first used in the Axially Symmetric Divertor EXperiment (ASDEX). Such gauges are considered state-of-the-art and are in wide use in fusion experiments, but they nonetheless suffer from a relatively high failure rate when operated at high magnetic field strengths for long times. This is therefore a significant concern for long-pulse, high-field experiments such as Wendelstein 7-X (W7-X) and ITER...
March 2018: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29604765/a-hydrogen-leak-tight-transparent-cryogenic-sample-container-for-ultracold-neutron-transmission-measurements
#16
Stefan Döge, Jürgen Hingerl
The improvement of the number of extractable ultracold neutrons (UCNs) from converters based on solid deuterium (sD2 ) crystals requires a good understanding of the UCN transport and how the crystal's morphology influences its transparency to the UCNs. Measurements of the UCN transmission through cryogenic liquids and solids of interest, such as hydrogen (H2 ) and deuterium (D2 ), require sample containers with thin, highly polished and optically transparent windows and a well defined sample thickness. One of the most difficult sealing problems is that of light gases like hydrogen and helium at low temperatures against high vacuum...
March 2018: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29604677/active-nonreciprocal-acoustic-metamaterials-using-a-switching-controller
#17
Amr Baz
A class of active acoustic diodes and metamaterials is developed to control the flow and distribution of acoustic energy in acoustic cavities and systems. Such development departs radically from the currently available approaches where the non-reciprocities are generated by hard-wired designs, favoring one transmission direction which is dictated by the arrangement of the hardware and hence it cannot be reversed, or without the presentation of rigorous control theory analysis. The proposed active nonreciprocal acoustic metamaterial (ANAM) cell consists of a one-dimensional acoustic cavity provided with active flexible boundaries...
March 2018: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/29602943/hemoptysis-after-cardiomems-implantation-case-report-and-review
#18
Aniket S Rali, Zubair Shah, Andrew J Sauer, Kamal Gupta
BACKGROUND The CardioMEMS heart failure system is a small sensor that is placed in a branch pulmonary artery for ambulatory monitoring of pulmonary artery pressures. CardioMEMS has been approved for use in the United States in patients with New York Heart Association (NYHA) class III heart failure and frequent hospitalizations. In this report we describe a patient who had hemoptysis after CardioMEMS implantation. Further, we discuss possible etiologies for the occurrence of hemoptysis and suggest strategies to minimize this risk...
March 31, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29578964/comparison-between-invasive-and-noninvasive-techniques-of-evaluation-of-microvascular-structural-alterations
#19
Carolina De Ciuceis, Claudia Agabiti Rosei, Stefano Caletti, Valentina Trapletti, Maria A Coschignano, Guido A M Tiberio, Sarah Duse, Franco Docchio, Simone Pasinetti, Federica Zambonardi, Francesco Semeraro, Enzo Porteri, Leonardo Solaini, Giovanna Sansoni, Paola Pileri, Claudia Rossini, Francesco Mittempergher, Nazario Portolani, Silvia Ministrini, Enrico Agabiti-Rosei, Damiano Rizzoni
BACKGROUND: The evaluation of the morphological characteristics of small resistance arteries in humans is challenging. The gold standard method is generally considered to be the measurement by wire or pressure micromyography of the media-to-lumen ratio of subcutaneous small vessels obtained by local biopsies. However, noninvasive techniques for the evaluation of retinal arterioles were recently proposed; in particular, two approaches, scanning laser Doppler flowmetry (SLDF) and adaptive optics, seem to provide useful information; both of them provide an estimation of the wall-to-lumen ratio (WLR) of retinal arterioles...
May 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29562079/physiology-guided-management-of-serial-coronary-artery-disease-a-review
#20
Bhavik N Modi, Kalpa De Silva, Ronak Rajani, Nick Curzen, Divaka Perera
Importance: Ischemia-guided revascularization is the cornerstone of contemporary management of coronary artery disease and has evolved from noninvasive functional evaluation to real-time assessment with invasive physiological indices during diagnostic catheterization. However, serial/diffuse disease is common, and revascularization decisions often need to be made about individual lesions within the same vessel. It is unclear whether current physiological techniques, such as fractional flow reserve, can be reliably used to discern the individual contribution of lesions within a serially diseased vessel with erroneous measurements, potentially leading to suboptimal revascularization decisions...
March 21, 2018: JAMA Cardiology
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