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Cough approach

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https://www.readbyqxmd.com/read/28290795/-a-breakthrough-in-the-treatment-of-patients-with-heart-failure-with-reduced-ejection-fraction-the-clinical-significance-of-the-paradigm-hf-trial
#1
Zh D Kobalava, S V Villevalde, O I Lukina
The implementation into clinical practice of new therapeutic strategies that could improve the prognosis of patients with heart failure (HF) with reduced ejection fraction (HFrEF) remains relevant. Innovative approach is to restore imbalances of neurohumoral systems by inhibiting angiotensin II receptor and neprilysin. The review presents the role of the natriuretic peptides system in the HFrEF pathophysiology, historical approaches to neurohormonal modulation, clinical pharmacology of the first in the class of angiotensin receptor and neprilysin inhibitor sakubitril/valsartan...
February 2017: Kardiologiia
https://www.readbyqxmd.com/read/28289448/when-is-cough-functional-and-how-should-it-be-treated
#2
REVIEW
Miles Weinberger, Boris Lockshin
KEY POINTS: Habit cough is most commonly characterised by a repetitive loud barking cough that persists for prolonged periods.The cough interferes with normal activity and substantially decreases the quality of life.The sine qua non is the total absence of this troublesome cough once asleep.The age distribution ranges from 4 years to late adolescence, with 85% of cases occurring from 8 to 14 years of age; similar cough in adults is much less common and poorly characterised.Pharmacological treatment is ineffective...
March 2017: Breathe
https://www.readbyqxmd.com/read/28288596/needles-jabs-and-jags-a-qualitative-exploration-of-barriers-and-facilitators-to-child-and-adult-immunisation-uptake-among-gypsies-travellers-and-roma
#3
Cath Jackson, Helen Bedford, Francine M Cheater, Louise Condon, Carol Emslie, Lana Ireland, Philippa Kemsley, Susan Kerr, Helen J Lewis, Julie Mytton, Karen Overend, Sarah Redsell, Zoe Richardson, Christine Shepherd, Lesley Smith, Lisa Dyson
BACKGROUND: Gypsies, Travellers and Roma (referred to as Travellers) are less likely to access health services including immunisation. To improve immunisation rates, it is necessary to understand what helps and hinders individuals in these communities in taking up immunisations. This study had two aims. 1. Investigate the views of Travellers in the UK on the barriers and facilitators to acceptability and uptake of immunisations and explore their ideas for improving immunisation uptake; 2...
March 14, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28283891/the-potential-role-for-early-biomarker-testing-as-part-of-a-modern-multidisciplinary-approach-to-sj%C3%A3-gren-s-syndrome-diagnosis
#4
REVIEW
Kenneth A Beckman, Jodi Luchs, Mark S Milner, Julian L Ambrus
Sjögren's syndrome (SS) is a chronic and progressive multisystem autoimmune disease typically managed by rheumatologists. Diagnostic delays are common, due in large part to the non-specific and variable nature of SS symptoms and the slow progression of disease. The hallmark characteristics of SS are dry eye and dry mouth, but there are a broad range of other possible symptoms such as joint and muscle pain, skin rashes, chronic dry cough, vaginal dryness, extremity numbness or tingling, and disabling fatigue...
March 10, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28272203/sarcoidosis-associated-with-infliximab-therapy-in-ulcerative-colitis-a-case-report
#5
Georgiana-Emmanuela Gîlcă, Smaranda Diaconescu, Gheorghe Gh Bălan, Oana Timofte, Gabriela Ştefănescu
RATIONALE: Although immunomodulatory therapy has been clearly stated as an important landmark in treatment of ulcerative colitis, significantly improving the quality of life for patients with inflammatory bowel disease, there are several aspects to be considered regarding the possible side-effects of anti-TNF alpha agents. In spite of a good safety profile, biologic TNF antagonists may induce paradoxical inflammation, which can manifest as sarcoid-like granulomatosis, consisting of noncaseating granulomas in the affected organs...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28269614/detection-of-different-types-of-noise-in-lung-sounds
#6
A Leal, R Couceiro, I Chouvarda, N Maglaveras, J Henriques, R Paiva, P Carvalho, C Teixeira
Lung sound signal processing has proven to be a great improvement to the traditional acoustic interpretation of lung sounds. However, that analysis can be seriously hindered by the presence of different types of noise originated in the acquisition environment or caused by physiological processes. Consequently, the diagnostic accuracy of pulmonary diseases can be severely affected, especially if the implementation of telemonitoring systems is considered. The present study is focused on the implementation of an algorithm able to identify noisy periods, either voluntarily (vocalizations, chest movement and background voices) or involuntarily produced during acquisitions of lung sounds...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28253209/short-article-aspiration-of-capsule-endoscopes-a-comprehensive-review-of-the-existing-literature
#7
Diana E Yung, John N Plevris, Anastasios Koulaouzidis
INTRODUCTION: Capsule endoscopy (CE) has an excellent safety profile. Although retention is the most cited complication, capsule aspiration is less frequent and is often reported only as isolated cases. This study represents a systematic effort to compile and scrutinize the available data on capsule aspiration to provide comprehensive and conclusive information on this CE complication. MATERIALS AND METHODS: A systematic literature search was performed in PubMed, Embase and Chinese National Knowledge Infrastructure...
April 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28252585/-the-modern-approach-to-the-conservative-treatment-of-the-patients-presenting-with-postoperative-bilateral-vocal-fold-palsy
#8
O Yu Karpova, V M Svistushkin
The objective of the preset study was to further improve the diagnostics and treatment of unilateral palsies of the laryngeal recurrent nerves associated with transitory reflective spasm of the functionally competent vocal fold. The study included 49 patients (46 women and 3 men) at the age varying from 21 to 75 years presenting with unilateral palsies of the laryngeal recurrent nerves associated with transitory reflective spasm of the functionally competent vocal fold that developed after the surgical intervention on the thyroid gland...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28251961/-anticytokine-therapy-of-allergic-asthma
#9
I P Shilovskiy, D V Eroshkina, A A Babakhin, M R Khaitov
Bronchial asthma is a chronic inflammatory disease of the airways that is characterized by episodes of shortness of breath, expiratory dyspnea, cough, wheezing, and pulmonary emphysema. At the present time, asthma is a global public health problem and affects about 5% of the worldwide population. Although a wide range of anti-inflammatory drugs is available, uncontrolled or poorly controlled asthma is still a problem, requiring the development of novel therapeutic approaches. Intense studies of the molecular mechanisms of asthma in transgenic animals performed since the 1990s implicated cytokines, such as IL-4, IL-5, and IL-13, and their receptors in the initiation and maintenance of asthma...
January 2017: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/28227872/detection-of-different-types-of-noise-in-lung-sounds
#10
A Leal, R Couceiro, I Chouvarda, N Maglaveras, J Henriques, R Paiva, P Carvalho, C Teixeira, A Leal, R Couceiro, I Chouvarda, N Maglaveras, J Henriques, R Paiva, P Carvalho, C Teixeira, R Couceiro, P Carvalho, C Teixeira, A Leal, R Paiva, J Henriques, N Maglaveras, I Chouvarda
Lung sound signal processing has proven to be a great improvement to the traditional acoustic interpretation of lung sounds. However, that analysis can be seriously hindered by the presence of different types of noise originated in the acquisition environment or caused by physiological processes. Consequently, the diagnostic accuracy of pulmonary diseases can be severely affected, especially if the implementation of telemonitoring systems is considered. The present study is focused on the implementation of an algorithm able to identify noisy periods, either voluntarily (vocalizations, chest movement and background voices) or involuntarily produced during acquisitions of lung sounds...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28223673/-a-case-of-meningeal-carcinomatosis-and-small-cell-lung-carcinoma-effectively-treated-using-a-multidisciplinary-approach
#11
Kota Hikima, Mikie Nagayama, Takashi Sato, Takashi Inoue, Mutsumi Nagai
A 65-year-old man visited our hospital with dyspnea and cough. He was diagnosed with small cell lung carcinoma (cT4N2M1b, Stage IV). The disease partially responded to systemic chemotherapy. However, it was progressive and metastasized to the brain 3 months after 6 courses of chemotherapy. Therefore, whole brain irradiation was performed. Subsequently, weakness of the lower extremities and vesicorectal disturbances appeared. Meningeal carcinomatosis was diagnosed by enhanced magnetic resonance imaging and liquid examination...
February 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28210329/respiratory-illness-in-children-with-disability-a-serious-problem
#12
REVIEW
Marijke Proesmans
KEY POINTS: Children with neurocognitive impairment often present with chronic or recurrent respiratory problems.The respiratory problems have an important impact on quality of life and life expectancy.The underlying causes are multiple: risk of aspiration, insufficient cough, upper airway obstruction and progressive kyphoscoliosis.There is often a complex interplay between these known risk factors.The diagnostic and therapeutic approach should be multidisciplinary. EDUCATIONAL AIMS: To provide data on the prevalence of respiratory problems in children with disability and to increase awareness on this topic...
December 2016: Breathe
https://www.readbyqxmd.com/read/28196638/japanese-guidelines-for-adult-asthma-2017
#13
REVIEW
Masakazu Ichinose, Hisatoshi Sugiura, Hiroyuki Nagase, Masao Yamaguchi, Hiromasa Inoue, Hironori Sagara, Jun Tamaoki, Yuji Tohda, Mitsuru Munakata, Kohei Yamauchi, Ken Ohta
Adult bronchial asthma is characterized by chronic airway inflammation, and presents clinically with variable airway narrowing (wheezes and dyspnea) and cough. Long-standing asthma induces airway remodeling, leading to intractable asthma. The number of patients with asthma has increased; however, the number of patients who die of asthma has decreased (1.2 per 100,000 patients in 2015). The goal of asthma treatment is to enable patients with asthma to attain normal pulmonary function and lead a normal life, without any symptoms...
February 11, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28188210/management-of-oral-secretions-in-neurological-disease
#14
REVIEW
Alexander J McGeachan, Christopher J Mcdermott
Sialorrhoea is a common and problematic symptom that arises from a range of neurological conditions associated with bulbar or facial muscle dysfunction. Drooling can significantly affect quality of life due to both physical complications such as oral chapping, and psychological complications such as embarrassment and social isolation. Thicker, tenacious oral and pharyngeal secretions may result from the drying management approach to sialorrhoea. The management of sialorrhoea in neurological diseases depends on the underlying pathology and severity of symptoms...
April 2017: Practical Neurology
https://www.readbyqxmd.com/read/28159630/improved-method-for-collection-of-sputum-for-tuberculosis-testing-to-ensure-adequate-sample-volumes-for-molecular-diagnostic-testing
#15
Mark Fisher, Tania Dolby, Shireen Surtie, Gaironesa Omar, Nchimunya Hapeela, Debby Basu, Abby DeWalt, David Kelso, Mark Nicol, Sally McFall
The quality and quantity of sputum collected has an important impact on the laboratory diagnosis of pulmonary TB. We conducted a pilot study to assess a new collection cups for the collection of sputum for the diagnosis of pulmonary tuberculosis. The pilot study utilized the standard collection cup in South Africa demonstrating a mean collection volume of 2.86±2.36SDml for 198 samples; 19% of the specimens contained <1ml and 12% contained >5ml. We designed and tested two novel sputum cups with a narrow bottom section and clear minimum and maximum markings to allow patients and clinicians to know whether sufficient sputum volume has been produced...
January 31, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28154281/fulminant-laryngeal-tracheobronchial-pulmonary-aspergillosis-a-rare-and-fatal-complication-in-allogeneic-hematopoietic-stem-cell-transplantation-recipients
#16
Tao Tao, Ying-Hui Zhang, Sheng-Li Xue, De-Pei Wu, Feng Chen
A 23-year-old man who had previously undergone allogeneic hematopoietic stem cell transplantation (allo-HSCT) for severe aplastic anemia was diagnosed with invasive laryngeal-tracheobronchial-pulmonary aspergillosis after presenting with a persistent dry cough at six months post-transplantation based on the findings of laryngoscopy and fiberoptic bronchoscopy. A fiberoptic bronchoscope was used to remove the obstructive material from the patient's airway and posaconazole plus caspofungin were administered to successfully to treat the patient...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28145196/recognition-and-management-of-foreign-body-ingestion-and-aspiration
#17
Oliver William McKinney, Paul Anthony Heaton, Jane Gamble, Siba Prosad Paul
Foreign body ingestion and foreign body aspiration commonly affect children. The most vulnerable age is between six months and four years, when children tend to explore new objects with their mouths. Many of these events remain asymptomatic, with the swallowed object passing through the gastrointestinal tract without causing harm. However, the frequency of serious complications as a result of the ingestion of hazardous objects has increased in recent years, in particular button batteries and magnets. To increase the likelihood of identifying foreign body ingestion and aspiration, healthcare professionals should maintain a high index of suspicion, be aware of the variation in presentations and include it as a differential diagnosis in children presenting with non-specific symptoms, such as fever, cough, drooling, dysphagia and abdominal pain...
February 1, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28108179/symptomatic-treatment-of-cough-among-adult-patients-with-lung-cancer-chest-guidelines-and-expert-panel-report
#18
Alex Molassiotis, Jaclyn A Smith, Peter Mazzone, Fiona Blackhall, Richard S Irwin
BACKGROUND: Cough among patients with lung cancer is a common but often undertreated symptom. We have used a recent Cochrane systematic review, among other sources of evidence, to update the recommendations and suggestions of the CHEST 2006 guideline on this topic. METHODS: The American College of Chest Physicians (CHEST) methodologic guidelines and the Grading of Recommendations, Assessment, Development, and Evaluation framework were used. The Expert Cough Panel based their recommendations on data from the Cochrane systematic review on the topic, uncontrolled studies, case studies, and the clinical context...
January 17, 2017: Chest
https://www.readbyqxmd.com/read/28104362/use-of-management-pathways-or-algorithms-in-children-with-chronic-cough-chest-guideline-and-expert-panel-report
#19
Anne B Chang, John J Oppenheimer, Miles M Weinberger, Bruce K Rubin, Kelly Weir, Cameron C Grant, Richard S Irwin
BACKGROUND: Using management algorithms or pathways potentially improves clinical outcomes. We undertook systematic reviews to examine various aspects in the generic approach (use of cough algorithms and tests) to the management of chronic cough in children (aged ≤14-years) based on key questions using the PICO format. METHODS: We used the CHEST expert cough panel's protocol for the systematic reviews and the American College of Chest Physicians (CHEST) methodological guidelines and GRADE framework...
January 16, 2017: Chest
https://www.readbyqxmd.com/read/28102319/temporal-topic-modeling-to-assess-associations-between-news-trends-and-infectious-disease-outbreaks
#20
Saurav Ghosh, Prithwish Chakraborty, Elaine O Nsoesie, Emily Cohn, Sumiko R Mekaru, John S Brownstein, Naren Ramakrishnan
In retrospective assessments, internet news reports have been shown to capture early reports of unknown infectious disease transmission prior to official laboratory confirmation. In general, media interest and reporting peaks and wanes during the course of an outbreak. In this study, we quantify the extent to which media interest during infectious disease outbreaks is indicative of trends of reported incidence. We introduce an approach that uses supervised temporal topic models to transform large corpora of news articles into temporal topic trends...
January 19, 2017: Scientific Reports
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