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https://www.readbyqxmd.com/read/28077337/stress-hormone-epinephrine-adrenaline-and-norepinephrine-noradrenaline-effects-on-the-anaerobic-bacteria
#1
REVIEW
Lyudmila Boyanova
Microbial endocrinology is a relatively new research area that already encompasses the anaerobes. Stress hormones, epinephrine and norepinephrine, can affect the growth of anaerobic bacteria such as Fusobacterium nucleatum, Prevotella spp., Porhyromonas spp., Tanerella forsythia and Propionibacterium acnes and can increase virulence gene expression, iron acquisition and many virulence factors of some anaerobic species such as Clostridium perfringens, Porphyromonas gingivalis and Brachyspira pilosicoli. Epinephrine and norepinephrine effects can lead to a growth increase or decrease, or no effect on the growth of the anaerobes...
January 8, 2017: Anaerobe
https://www.readbyqxmd.com/read/28070801/a-comparison-of-sexual-function-in-women-with-polycystic-ovary-syndrome-pcos-whose-mothers-had-pcos-during-their-pregnancy-period-with-those-without-pcos
#2
Mahsa Noroozzadeh, Fahimeh Ramezani Tehrani, Mahnaz Bahri Khomami, Fereidoun Azizi
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women during reproductive ages. Clinical symptoms associated with PCOS, such as hirsutism, acne, alopecia, obesity, and infertility, may lead to emotional morbidity and then impaired sexual function in those affected. During intrauterine development, the fetus may program the development of diseases during adulthood. In this study, we aimed to examine sexual function in women with PCOS, exposed to maternal androgen excess during their prenatal life compared to non-exposed PCOS patients...
January 9, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28031728/the-frequency-of-polycystic-ovary-syndrome-in-young-reproductive-females-in-qatar
#3
Elham Sharif, Sumaya Rahman, Yumna Zia, Nasser M Rizk
This was a prospective cross-sectional study in which 126 female students between the ages of 18 and 30 years were evaluated for the frequency of polycystic ovary syndrome (PCOS) through clinical interview, questionnaire, and anthropometric measurements. The diagnostic criteria of the US National Institutes of Health criteria were used. Menstrual irregularities (MI) were identified, and clinical hyperandrogenism was evaluated by self-assessment of hirsutism using modified Ferriman-Gallwey score. Blood analysis was done for measurement of prolactin, thyroid-stimulating hormone, and the androgen hormones...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28025036/decreased-eicosapentaenoic-acid-levels-in-acne-vulgaris-reveals-the-presence-of-a-proinflammatory-state
#4
İbrahim Aslan, Filiz Özcan, Taner Karaarslan, Ebru Kıraç, Mutay Aslan
This study aimed to determine circulating levels of polyunsaturated fatty acids (PUFAs), secretory phospholipase A2 (sPLA2), lipoprotein lipase (LPL) and measure circulating protein levels of angiopoietin-like protein 3 (ANGPTL3), ANGPTL4, cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) in patients with acne vulgaris. Serum from 21 control subjects and 31 acne vulgaris patients were evaluated for levels of arachidonic acid (AA, C20:4n- 6), dihomo-gamma-linolenic acid (DGLA, C20:3n-6), eicosapentaenoic acid (EPA, C20:5n-3) and docosahexaenoic acid (DHA, C22:6n-3)...
December 23, 2016: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/27968930/acne-kids-are-not-just-little-people
#5
Syril Keena T Que, Diane L Whitaker-Worth, Mary Wu Chang
Acne vulgaris is a common inflammatory disease of the pilosebaceous follicles that affects patients of all ages, from neonates to adults. We have compared and contrasted the clinical presentation of acne in neonates, infants, children, teenagers, and young adults and review the scenarios in which further systemic endocrine or hormonal tests are indicated. We also discuss age-dependent treatment considerations, including appropriate oral antimicrobial regimens and the proper dosing of isotretinoin in young children versus teenagers and adults...
November 2016: Clinics in Dermatology
https://www.readbyqxmd.com/read/27959277/endothelial-dysfunction-may-play-a-key-role-in-keloid-and-hypertrophic-scar-pathogenesis-keloids-and-hypertrophic-scars-may-be-vascular-disorders
#6
Rei Ogawa, Satoshi Akaishi
Keloids and hypertrophic scars are fibroproliferative disorders (FPDs) of the skin that result from abnormal healing of injured or irritated skin. They can be called pathological or inflammatory scars. Common causes are trauma, burn, surgery, vaccination, skin piercing, folliculitis, acne, and herpes zoster infection. The pathogenesis of these scars clearly involves local conditions such as delayed wound healing, wound depth, and the tension of the skin around the scars. Scar severity is also shaped by interactions between these local factors and genetic and systemic factors such as hypertension and sex hormones...
November 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27916205/efficacy-and-safety-of-transdermal-testosterone-in-postmenopausal-women-with-hypoactive-sexual-desire-disorder-a-systematic-review-and-meta-analysis
#7
Chiara Achilli, Jyotsna Pundir, Parimalam Ramanathan, Luca Sabatini, Haitham Hamoda, Nick Panay
OBJECTIVE: To systematically review and summarize the existing evidence related to the efficacy and safety of transdermal T in postmenopausal women for the treatment of hypoactive sexual desire disorder (HSDD). DESIGN: Systematic reviews and meta-analysis. SETTING: Not applicable. PATIENT(S): Seven randomized controlled trials enrolled 3,035 participants; 1,350 women were randomized to treatment with T patch, and 1,379 women were randomized to placebo...
December 1, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27906711/polycystic-ovary-syndrome-in-adolescent-girls
#8
Natalie Hecht Baldauff, Selma Feldman Witchel
PURPOSE OF REVIEW: Polycystic ovary syndrome (PCOS) is a common heterogeneous disorder that appears to have its origins during the peripubertal years. The diagnostic conundrum is that the typical clinical features, irregular menses and acne, occur during normal female puberty. Understanding the physiologic origins and molecular basis of the dysregulated hypothalamic-pituitary-gonadal axis in PCOS is fundamental to interrupting the distinctive vicious cycle of hyperandrogenism and chronic anovulation...
February 2017: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/27817838/noncontraceptive-use-of-oral-combined-hormonal-contraceptives-in-polycystic-ovary-syndrome-risks-versus-benefits
#9
REVIEW
Anuja Dokras
The use of steroid sex hormones for noncontraceptive benefits has been endorsed by several medical societies. In women with polycystic ovary syndrome (PCOS), hormonal contraceptives are first-line therapy for concurrent treatment of menstrual irregularity, acne, and hirsutism. The association of PCOS with obesity, diabetes, and dyslipidemia frequently brings up the debate regarding risks versus benefits of hormonal contraceptives in this population. In women with PCOS, the lack of large-scale studies evaluating the risks with varying doses of ethinyl estradiol, types of progestins, and presence of confounding factors such as obesity, smoking, and other cardiometabolic comorbidities is a significant limitation in these deliberations...
December 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27803511/survivin-as-a-novel-biomarker-in-the-pathogenesis-of-acne-vulgaris-and-its-correlation-to-insulin-like-growth-factor-i
#10
Hanan A Assaf, Wafaa M Abdel-Maged, Bakheet E M Elsadek, Mohammed H Hassan, Mohamed A Adly, Soher A Ali
Survivin, a member of the inhibitor of apoptosis protein family, has an important role in cell cycle regulation. Insulin-like growth factor-I (IGF-I) is a polypeptide hormone with wide range of biologic effects including stimulation of lipogenesis in sebaceous glands. Their overexpression in some fibrotic disorders suggests a possible implication of both IGF-I and survivin in the pathogenesis of acne and/or acne scars. The current study aimed to assess and correlate serum levels of IGF-I and survivin in patients with active acne vulgaris and postinflammatory acne scars and to evaluate their lesional expressions in comparison to healthy controls...
2016: Disease Markers
https://www.readbyqxmd.com/read/27788052/efficacy-and-safety-of-an-injectable-combination-hormonal-contraceptive-for-men
#11
Hermann M Behre, Michael Zitzmann, Richard A Anderson, David J Handelsman, Silvia W Lestari, Robert I McLachlan, M Cristina Meriggiola, Man Mohan Misro, Gabriela Noe, Frederick C W Wu, Mario Philip R Festin, Ndema A Habib, Kirsten M Vogelsong, Marianne M Callahan, Kim A Linton, Doug S Colvard
CONTEXT: The development of a safe and effective reversible method of male contraception is still an unmet need. OBJECTIVE: Evaluation of suppression of spermatogenesis and contraceptive protection by coadministered im injections of progestogen and testosterone. DESIGN: Prospective multicentre study. SETTING: Ten study centers. PARTICIPANTS: Healthy men, aged 18-45 years, and their 18- to 38-year-old female partners, both without known fertility problems...
December 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27769766/prescribing-of-cyproterone-acetate-ethinylestradiol-in-uk-general-practice-a-retrospective-descriptive-study-using-the-health-improvement-network
#12
Lucía Cea Soriano, Alex Asiimwe, Luis A García Rodriguez
OBJECTIVE: To investigate prescribing patterns of cyproterone acetate/ethinylestradiol (CPA/EE) in the United Kingdom before and after the 2013 prescribing guidance. STUDY DESIGN: We conducted a retrospective descriptive study in UK general practice. The study population included women with a first prescription (index date) for CPA/EE in The Health Improvement Network in 2011 (N=2760), 2012 (N=2923) and 2014 (N=2341). We evaluated the proportion of new CPA/EE users with (i) a diagnosis of a hyperandrogenic condition, menstrual problem, consultation for contraception management, and other acne treatment, in the year before the index date; and (ii) proportion of new CPA/EE users with concomitant use of another hormonal contraceptive (HC)...
October 18, 2016: Contraception
https://www.readbyqxmd.com/read/27766947/vascular-endothelial-growth-factor-vegfa-gene-variation-in-polycystic-ovary-syndrome-in-a-tunisian-women-population
#13
Assila Ben Salem, Fatma Megdich, Olfa Kacem, Malek Souayeh, Faten Hachani Ben Ali, Sondes Hizem, Faouzi Janhai, Mounir Ajina, Muhammad Abu-Elmagd, Mourad Assidi, Mohammed H Al Qahtani, Touhami Mahjoub
BACKGROUND: Polycystic ovary syndrome (PCOS) is characterized by the growth of a number of small cysts on the ovaries which leads to sex hormonal imbalance. Women who are affected by this syndrome suffer from irregular menstrual cycles, decline in their fertility, excessive hair growth, obesity, acne and most importantly cardiac function problems. The vascular endothelial growth factor (VEGF) plays a pivotal role in tissue vascularization in general and in the pathogenesis of many diseases...
October 17, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27761789/skin-steroidogenesis-in-health-and-disease
#14
REVIEW
Georgios Nikolakis, Constantine A Stratakis, Theodora Kanaki, Andrej Slominski, Christos C Zouboulis
The skin is an important extra-gonadal steroidogenic organ, capable of metabolizing various hormones from their precursors, as well as of synthesizing de novo a broad palette of sex steroids and glucocorticoids from cholesterol. In this manuscript, we review the major steroidogenic properties of human skin and we suggest steroidogenesis' impairment as a cardinal factor for various pathological conditions such as acne, rosacea, atopic dermatitis, and androgenic alopecia.
September 2016: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/27621661/hormonal-treatment-of-acne-vulgaris-an-update
#15
REVIEW
Mohamed L Elsaie
Acne vulgaris is a common skin condition associated with multiple factors. Although mostly presenting alone, it can likewise present with features of hyperandrogenism and hormonal discrepancies. Of note, hormonal therapies are indicated in severe, resistant-to-treatment cases and in those with monthly flare-ups and when standard therapeutic options are inappropriate. This article serves as an update to hormonal pathogenesis of acne, discusses the basics of endocrinal evaluation for patients with suspected hormonal acne, and provides an overview of the current hormonal treatment options in women...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27529209/treatment-modalities-for-acne
#16
REVIEW
Lizelle Fox, Candice Csongradi, Marique Aucamp, Jeanetta du Plessis, Minja Gerber
Acne is a common inflammatory skin disease which affects the pilosebaceous units of the skin. It can have severe psychological effects and can leave the patient with severe skin scarring. There are four well-recognized pathological factors responsible for acne which is also the target for acne therapy. In this review, different treatment options are discussed, including topical (i.e., retinoids, and antibiotics) and systemic (i.e., retinoids, antibiotics, and hormonal) treatments. Since the general public has been showing an increasing interest in more natural and generally safer treatment options, the use of complementary and alternative medicines (CAM) for treating acne was also discussed...
August 13, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27526961/polycystic-ovary-syndrome-patients-with-high-bmi-tend-to-have-functional-disorders-of-androgen-excess-a-prospective-study
#17
Chun Yuan, Xiaoqiang Liu, Yundong Mao, Feiyang Diao, Yugui Cui, Jiayin Liu
Biochemical or clinical changes of hyperandrogenism are important elements of polycystic ovary syndrome (PCOS). There is currently no consensus on the definition and diagnostic criteria of hyperandrogenism in PCOS. The aim of this study was to investigate the complex symptoms of hyperandrogenic disorders and the correlations between metabolism and hyperandrogenism in patients with PCOS from an outpatient reproductive medicine clinic in China. We conducted a case control study of 125 PCOS patients and 130 controls to evaluate differences in body mass index (BMI), total testosterone (TT), modified Ferriman-Gallwey hirsutism score, sex hormone binding globulin (SHBG), homeostasis model assessment-estimated insulin resistance (HOMA-IR) and free androgen index (FAI) between PCOS patients and controls and subgroups of PCOS...
May 2016: Journal of Biomedical Research
https://www.readbyqxmd.com/read/27515365/synthetic-hormones-and-clot-formation
#18
Albe C Swanepoel, Amcois Visagie, Etheresia Pretorius
Combined oral contraceptives (COCs), colloquially referred to as "the pill," have been regarded as a medical breakthrough, as they have improved the lives of countless women, from simplifying family planning to the treatment of acne, endometriosis, polycystic ovarian syndrome, and dysmenorrhea. Unfortunately, COC usage has been associated with an increased occurrence of venous thrombosis and therefore a systemic hypercoagulable state in susceptible females. Here we discuss the health risks of COC usage and use viscoelastic and morphological techniques to investigate the effect of different COC constituents on clot formation, particularly fibrin network packaging and whole blood viscoelasticity...
August 2016: Microscopy and Microanalysis
https://www.readbyqxmd.com/read/27512490/adrenal-cushing-s-syndrome-in-pregnancy-clinical-and-molecular-characterisation-of-a-case
#19
Anne Trinh, Irene Chan, Maria Alexiadis, Medina Pell, Beena Kumar, Peter J Fuller
BACKGROUND: Cushing's syndrome is rare during pregnancy and more commonly due to adrenal pathology, in contrast to the non-pregnant population. Increased levels of cortisol-binding globulin and placental production of corticotropin-releasing hormone and adrenocorticotropic hormone complicate the diagnostic strategies usually employed. CASE: A 32-year-old G1P0 at 15/40 gestation presented with severe peripheral oedema and excessive weight gain. Examination revealed pitting oedema to the abdominal wall, wide violaceous striae, moon facies and acne...
March 2016: Obstetric Medicine
https://www.readbyqxmd.com/read/27489429/stressful-events-and-serum-concentration-of-substance-p-in-acne-patients
#20
Anita Rokowska-Waluch, Mariola Pawlaczyk, Marcin Cybulski, Jakub Żurawski, Mariusz Kaczmarek, Michał Michalak, Ewa Mojs
BACKGROUND: Psychological stress is an important factor of acne pathogenesis. Stress related production of hormones, cytokines and neuropeptides may result in the chronic course and exacerbations of the disease. OBJECTIVE: The aim of the study was to evaluate the relationship between acne severity, intensity of emotional stress and serum concentration of substance P (scSP), to compare the intensity of adversities, psychological stress and scSP in acne patients with healthy controls and to compare coping techniques for stress...
August 2016: Annals of Dermatology
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