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Mitra Shojania Feizabadi
BACKGROUND: Drug-induced resistance is one the major obstacles that may lead to therapeutic failure during cancer treatment. Different genetic alterations occur when tumor cells divide. Among new generations of tumor cells, some may express intrinsic resistance to a specific chemotherapeutic agent. Also, some tumor cells may carry a gene that can develop resistance induced by the therapeutic drug. The methods by which the therapeutic approaches need to be revised in the occurrence of drug induced resistance is still being explored...
March 21, 2017: Theoretical Biology & Medical Modelling
Patricia Trbovich, Kaveh G Shojania
No abstract text is available yet for this article.
February 21, 2017: BMJ Quality & Safety
Jerome Bouquet, Jennifer L Gardy, Scott Brown, Jacob Pfeil, Ruth R Miller, Muhammad Morshed, Antonio Avina-Zubieta, Kam Shojania, Mark McCabe, Shoshana Parker, Miguel Uyaguari, Scot Federman, Patrick Tang, Ted Steiner, Michael Otterstater, Rob Holt, Richard Moore, Charles Y Chiu, David M Patrick
No abstract text is available yet for this article.
February 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Mitra Shojania Feizabadi, Brandon Rosario
There is known to be significant diversity of β-tubulin isoforms in cells. However, whether the functions of microtubules that are polymerized from different distributions of beta isotypes become distinct from one another are still being explored. Of particular interest, recent studies have identified the role that different beta tubulin isotypes carry in regulating the functions of some of the molecular motors along MCF7, or breast cancer, microtubules. That being said, how the specific distribution of beta tubulin isotypes impacts the MCF7 microtubules' dynamic is not well understood...
January 26, 2017: Biochemical and Biophysical Research Communications
Sharan K Rai, J Antonio Aviña-Zubieta, Natalie McCormick, Mary A De Vera, Kam Shojania, Eric C Sayre, Hyon K Choi
OBJECTIVES: Gout is increasingly recognized as the most common form of inflammatory arthritis worldwide; however, no Canadian data on the disease burden of gout are available. We estimated the prevalence, incidence, prescription patterns, and comorbidity burden of gout in an entire Canadian province [British Columbia (BC)] over the last decade. METHODS: We utilized PopulationData BC, a province-wide database, to estimate temporal trends in the prevalence and incidence of gout from 2000 to 2012, as well as according to age category...
February 2017: Seminars in Arthritis and Rheumatism
Jerome A Leis, Kaveh G Shojania
No abstract text is available yet for this article.
December 16, 2016: BMJ Quality & Safety
Kaveh G Shojania, Mary Dixon-Woods
No abstract text is available yet for this article.
October 12, 2016: BMJ Quality & Safety
Onil Bhattacharyya, Michael Schull, Kaveh Shojania, Vicky Stergiopoulos, Gary Naglie, Fiona Webster, Ricardo Brandao, Tamara Mohammed, Jennifer Christian, Gillian Hawker, Lynn Wilson, Wendy Levinson
Integrating care for people with complex needs is challenging. Indeed, evidence of solutions is mixed, and therefore, well-designed, shared evaluation approaches are needed to create cumulative learning. The Toronto-based Building Bridges to Integrate Care (BRIDGES) collaborative provided resources to refine and test nine new models linking primary, hospital and community care. It used mixed methods, a cross-project meta-evaluation and shared outcome measures. Given the range of skills required to develop effective interventions, a novel incubator was used to test and spread opportunities for system integration that included operational expertise and support for evaluation and process improvement...
2016: Healthcare Quarterly
Mitra Shojania Feizabadi, Yonggun Jun, J N Babu Reddy
The kinesin 5 motor contributes critically to mitosis, and is often upregulated in cancer. In vitro motility studies of kinesin 5 moving along bovine brain microtubules indicate that the motors have limited processivity. Cancer cells have abnormal mitotic behavior, so one might wonder whether the functional properties of kinesin 5 change in such a background. Because there could be multiple unknown changes in cancerous vs normal cells, we chose to address this question in a controlled in vitro environment...
September 30, 2016: Biochemical and Biophysical Research Communications
Mitra Shojania Feizabadi
The extent to which beta tubulin isotypes contribute to the function of microtubules and the microtubule-driven transport of molecular motors is poorly understood. The major differences in these isotypes are associated with the structure of their C-terminal tails. Recent studies have revealed a few aspects of the C-terminal tails' regulatory role on the activities of some of the motor proteins on a single-molecule level. However, little attention is given to the degree to which the function of a team of motor proteins can be altered by the microtubule's tail...
September 2016: Cell Biochemistry and Biophysics
Adam Kovacs-Litman, Kimberly Wong, Kaveh G Shojania, Sandra Callery, Mary Vearncombe, Jerome A Leis
Physicians are notorious for poor hand hygiene (HH) compliance. We wondered if lower performance by physicians compared with other health professionals might reflect differences in the Hawthorne effect. We introduced covert HH observers to see if performance differences between physicians and nurses decreased and to gain further insights into physician HH behaviors. Following training and validation with a hospital HH auditor, 2 students covertly measured HH during clinical rotations. Students rotated off clinical services every week to increase exposure to different providers and minimize risk of exposing the covert observation...
December 2016: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
Nick Bansback, Kam Shojania, Diane Lacaille
No abstract text is available yet for this article.
October 4, 2016: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
Michael Samycia, Collette McCourt, Kam Shojania, Sheila Au
BACKGROUND: The Dermatology and Rheumatology Treatment Clinic is a novel multidisciplinary clinic where patients are concomitantly assessed by a rheumatologist and dermatologist. OBJECTIVES: To determine the number of patients seen in clinic, patient demographics, and most common diagnoses. METHOD: A retrospective review was performed over a 2-year period. Data collected included patient age, sex, dermatologic diagnosis, rheumatologic diagnosis, biopsies performed, and number of follow-up visits...
September 2016: Journal of Cutaneous Medicine and Surgery
Tejal K Gandhi, Donald M Berwick, Kaveh G Shojania
No abstract text is available yet for this article.
May 3, 2016: JAMA: the Journal of the American Medical Association
Margaret Sampson, Berry de Bruijn, Christine Urquhart, Kaveh Shojania
OBJECTIVES: To maximize the proportion of relevant studies identified for inclusion in systematic reviews (recall), complex time-consuming Boolean searches across multiple databases are common. Although MEDLINE provides excellent coverage of health science evidence, it has proved challenging to achieve high levels of recall through Boolean searches alone. STUDY DESIGN AND SETTING: Recall of one Boolean search method, the clinical query (CQ), combined with a ranking method, support vector machine (SVM), or PubMed-related articles, was tested against a gold standard of studies added to 6 updated Cochrane reviews and 10 Agency for Healthcare Research and Quality (AHRQ) evidence reviews...
March 11, 2016: Journal of Clinical Epidemiology
Emélie Braschi, Kam Shojania, G Michael Allan
No abstract text is available yet for this article.
March 2016: Canadian Family Physician Médecin de Famille Canadien
Alfred Cividino, Volodko Bakowsky, Susan Barr, Louis Bessette, Elizabeth Hazel, Nader Khalidi, Janet Pope, David Robinson, Kam Shojania, Elaine Yacyshyn, Lynne Lohfeld, Diane Crawshaw
OBJECTIVE: To identify what learners and professionals associated with rheumatology programs across Canada recommend as ways to attract future trainees. METHODS: Data from online surveys and individual interviews with participants from 9 rheumatology programs were analyzed using the thematic framework analysis to identify messages and methods to interest potential trainees in rheumatology. RESULTS: There were 103 participants (78 surveyed, 25 interviewed) who indicated that many practitioners were drawn to rheumatology because of the aspects of work life, and that educational events and hands-on experiences can interest students...
April 2016: Journal of Rheumatology
E Etchells, M Ho, K G Shojania
No abstract text is available yet for this article.
March 2016: BMJ Quality & Safety
Ian Ty Wong, Kam Shojania, Jan Dutz, Nicole W Tsao
Secukinumab represents the first IL-17A antagonist among the available biologic therapies approved for moderate-to-severe plaque psoriasis management. Secukinumab demonstrated greater efficacy over placebo, etanercept and ustekinumab in patients that had limited benefit from non-biologic systemic therapies and phototherapy. Despite standard-of-care systemic therapies being more likely to be cost-effective at this time, a Canadian cost-utility analysis found secukinumab to display benefit in quality-of-life gains in moderate-to-severe plaque psoriasis patients, and greater cost-effectiveness when compared to other biologic systemic therapies...
2016: Expert Review of Pharmacoeconomics & Outcomes Research
Lucy McGeoch, Marinka Twilt, Leilani Famorca, Volodko Bakowsky, Lillian Barra, Susan Benseler, David A Cabral, Simon Carette, Gerald P Cox, Navjot Dhindsa, Christine Dipchand, Aurore Fifi-Mah, Michele Goulet, Nader Khalidi, Majed M Khraishi, Patrick Liang, Nataliya Milman, Christian A Pineau, Heather Reich, Nooshin Samadi, Kam Shojania, Regina Taylor-Gjevre, Tanveer E Towheed, Judith Trudeau, Michael Walsh, Elaine Yacyshyn, Christian Pagnoux
The Canadian Vasculitis research network (CanVasc) is composed of physicians from different medical specialties, including rheumatology and nephrology and researchers with expertise in vasculitis. One of its aims was to develop recommendations for the diagnosis and management of antineutrophil cytoplasm antibody (ANCA)-associated vasculitides in Canada. This executive summary features the 19 recommendations and 17 statements addressing general AAV diagnosis and management, developed by CanVasc group based on a synthesis of existing international guidelines, other published supporting evidence and expert consensus considering the Canadian healthcare context...
2015: Canadian Journal of Kidney Health and Disease
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