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https://www.readbyqxmd.com/read/29672772/key-barriers-to-gout-care-a-systematic-review-and-thematic-synthesis-of-qualitative-studies
#1
Sharan K Rai, Hyon K Choi, Sally H J Choi, Anne F Townsend, Kam Shojania, Mary A De Vera
Objectives: Gout care remains highly suboptimal, contributing to an increased global disease burden. To understand barriers to gout care, our aim was to provide a systematic review and thematic synthesis of qualitative studies worldwide reporting provider and patient perspectives and experiences with management. Methods: We conducted a mapped search of MEDLINE, EMBASE, Cumulative Index to Nursing and Allied Health Literature, and Social Sciences Citation Index databases and selected qualitative studies of provider and patient perspectives on gout management...
April 17, 2018: Rheumatology
https://www.readbyqxmd.com/read/29511090/pathology-of-poverty-the-need-for-quality-improvement-efforts-to-address-social-determinants-of-health
#2
Andrew S Boozary, Kaveh G Shojania
No abstract text is available yet for this article.
March 6, 2018: BMJ Quality & Safety
https://www.readbyqxmd.com/read/29507123/the-data-of-diagnostic-error-big-large-and-small
#3
Gurpreet Dhaliwal, Kaveh G Shojania
No abstract text is available yet for this article.
March 5, 2018: BMJ Quality & Safety
https://www.readbyqxmd.com/read/29440483/rigorous-evaluations-of-evolving-interventions-can-we-have-our-cake-and-eat-it-too
#4
Robert E Burke, Kaveh G Shojania
No abstract text is available yet for this article.
April 2018: BMJ Quality & Safety
https://www.readbyqxmd.com/read/29414433/il-6-expression-is-correlated-with-increased-t-cell-proliferation-and-survival-in-the-arterial-wall-in-giant-cell-arteritis
#5
Sukhbir Manku, Wendy Wong, Zongshu Luo, Michael A Seidman, Zainab Alabdurubalnabi, Kevin Rey, Winnie Enns, J Antonio Avina-Zubieta, Kamran Shojania, Jonathan C Choy
Giant cell arteritis (GCA) is the most common vasculitis in adults affecting large and medium-sized arteries. IL-6 and T cell accumulation within the arterial wall contribute to the pathogenesis of GCA, and blockade of IL-6 activity is efficacious in its treatment. We examined the relationship between levels of IL-6 expression and immunological processes that control the expansion of T cells in GCA-positive temporal artery biopsies. CD4 T cells accumulated in clusters within the media and deep intima of all GCA lesions...
March 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29352419/a-systematic-review-of-interventions-to-follow-up-test-results-pending-at-discharge
#6
Patrick J Darragh, T Bodley, A Orchanian-Cheff, K G Shojania, J L Kwan, P Cram
BACKGROUND: Patients are frequently discharged from the hospital before all test results have been finalized. Thirty to 40% of tests pending at discharge (TPADs) return potentially actionable results that could necessitate change in the patients' management, often unbeknownst to their physicians. Delayed follow-up of TPADs can lead to patient harm. We sought to synthesize the existing literature on interventions intended to improve the management of TPADs, including interventions designed to enhance documentation of TPADs, increase physician awareness when TPAD results finalize post-discharge, decrease adverse events related to missed TPADs, and increase physician satisfaction with TPAD management...
January 19, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29232325/utility-of-electronic-medical-records-in-community-rheumatology-practice-for-assessing-quality-of-care-indicators-for-gout-a-feasibility-study
#7
Augusto Estrada, Nicole W Tsao, Alyssa Howren, John M Esdaile, Kamran Shojania, Mary A De Vera
OBJECTIVES: With comprehensive capture of information on patient encounters, electronic medical records (EMRs) may have utility for assessing adherence to quality indicators (QIs) in gout. Our objectives were to translate 10 previously established gout QIs into relevant EMR data and evaluate and describe the feasibility of using EMRs to assess gout QIs. METHODS: Using EMRs from 3 community rheumatology practices in Vancouver, British Columbia, Canada, we identified gout patients seen between January 1, 2012, and December 31, 2013...
March 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29180459/inpatient-bedspacing-could-a-common-response-to-hospital-crowding-cause-increased-patient-mortality
#8
Finlay A McAlister, Kaveh G Shojania
No abstract text is available yet for this article.
January 2018: BMJ Quality & Safety
https://www.readbyqxmd.com/read/29069119/do-combined-pharmacist-and-prescriber-efforts-on-medication-reconciliation-reduce-postdischarge-patient-emergency-department-visits-and-hospital-readmissions
#9
Michelle Baker, Chaim M Bell, Wei Xiong, Edward Etchells, Peter G Rossos, Kaveh G Shojania, Kelly Lane, Tim Tripp, Mary Lam, Kimindra Tiwana, Derek Leong, Gary Wong, Jin-Hyeun Huh Huh, Emily Musing, Olavo Fernandes
BACKGROUND: Although medication reconciliation (Med Rec) has demonstrated a reduction in potential adverse drug events, its effect on hospital readmissions remains inconclusive. OBJECTIVE: To evaluate the impact of an interprofessional Med Rec bundle from admission to discharge on patient emergency department visits and hospital readmissions (hospital visits). METHODS: The design was a retrospective, cohort study. Patients discharged from general internal medicine over a 57-month interval were identified through administrative databases...
March 1, 2018: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/28887032/electrostatic-differences-a-possible-source-for-the-functional-differences-between-mcf7-and-brain-microtubules
#10
Mitra Shojania Feizabadi, Brandon Rosario, Marcos A V Hernandez
Recent studies suggested a link between diversity of beta tubulin isotypes in microtubule structures and the regulatory roles that they play not only on microtubules' intrinsic dynamic, but also on the translocation characteristics of some of the molecular motors along microtubules. Remarkably, unlike porcine brain microtubules, MCF7 microtubules are structured from a different beta tubulin distribution. These types of cancer microtubules show a relatively stable and slow dynamic. In addition, the translocation parameters of some molecular motors are distinctly different along MCF7 as compared to those parameters on brain microtubules...
November 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28877926/effectiveness-of-quality-improvement-strategies-for-the-management-of-ckd-a-meta-analysis
#11
Samuel A Silver, Chaim M Bell, Glenn M Chertow, Prakesh S Shah, Kaveh Shojania, Ron Wald, Ziv Harel
BACKGROUND AND OBJECTIVES: Quality improvement interventions have enhanced care for other chronic illnesses, but their effectiveness for patients with CKD is unknown. We sought to determine the effects of quality improvement strategies on clinical outcomes in adult patients with nondialysis-requiring CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted a systematic review of randomized trials, searching Medline and the Cochrane Effective Practice and Organization of Care database from January of 2003 to April of 2015...
October 6, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28797395/organizing-pneumonia-in-an-adult-with-chronic-recurrent-noninfectious-osteomyelitis-a-case-report-and-literature-review
#12
REVIEW
Tiffany A Winstone, Robert D Levy, Kamran Shojania, Darra Murphy, Andrew Churg, Chris Ryerson
Chronic recurrent multifocal osteomyelitis (CRMO) is an idiopathic inflammatory disorder primarily of children and adolescents that is characterized by multifocal nonpyogenic relapsing and remitting inflammatory bone lesions. Pulmonary abnormalities are rarely associated with CRMO, with two reported cases of consolidation on chest CT that occurred in children. We present a case of organizing pneumonia in an adult patient with CRMO. The concurrent worsening of pulmonary and bone disease suggests that CRMO may be a rare cause of organizing pneumonia...
August 2017: Chest
https://www.readbyqxmd.com/read/28746138/faculty-resident-co-learning-a-longitudinal-exploration-of-an-innovative-model-for-faculty-development-in-quality-improvement
#13
Brian M Wong, Joanne Goldman, Jeannette M Goguen, Christian Base, Leahora Rotteau, Elaine Van Melle, Ayelet Kuper, Kaveh G Shojania
PURPOSE: To examine the effectiveness of co-learning, wherein faculty and trainees learn together, as a novel approach for building quality improvement (QI) faculty capacity. METHOD: From July 2012 through September 2015, the authors conducted 30 semistructured interviews with 23 faculty participants from the Co-Learning QI Curriculum of the Department of Medicine, Faculty of Medicine, University of Toronto, and collected descriptive data on faculty participation and resident evaluations of teaching effectiveness...
August 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28668805/-rheum-to-improve-quality-improvement-in-outpatient-rheumatology
#14
REVIEW
Shirley L Chow, Kaveh G Shojania
The commitment to improve care processes and patient outcomes is a professional mandate for clinicians and is also seen as an operational priority for institutions. Quality improvement now figures in the accreditation of training programs, specialty examinations, and hospital scorecards. Rheumatologists have traditionally focused primarily on quality problems such as guideline adherence; however, improvement goals should also include other aspects of care that are helpful to patients and are professionally rewarding for practitioners...
September 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28327183/modeling-multi-mutation-and-drug-resistance-analysis-of-some-case-studies
#15
Mitra Shojania Feizabadi
BACKGROUND: Drug-induced resistance is one the major obstacles that may lead to therapeutic failure during cancer treatment. Different genetic alterations occur when tumor cells divide. Among new generations of tumor cells, some may express intrinsic resistance to a specific chemotherapeutic agent. Also, some tumor cells may carry a gene that can develop resistance induced by the therapeutic drug. The methods by which the therapeutic approaches need to be revised in the occurrence of drug induced resistance is still being explored...
March 21, 2017: Theoretical Biology & Medical Modelling
https://www.readbyqxmd.com/read/28228469/root-cause-analysis-swatting-at-mosquitoes-versus-draining-the-swamp
#16
EDITORIAL
Patricia Trbovich, Kaveh G Shojania
No abstract text is available yet for this article.
May 2017: BMJ Quality & Safety
https://www.readbyqxmd.com/read/28172519/rna-seq-analysis-of-gene-expression-viral-pathogen-and-b-cell-t-cell-receptor-signatures-in-complex-chronic-disease
#17
Jerome Bouquet, Jennifer L Gardy, Scott Brown, Jacob Pfeil, Ruth R Miller, Muhammad Morshed, Antonio Avina-Zubieta, Kam Shojania, Mark McCabe, Shoshana Parker, Miguel Uyaguari, Scot Federman, Patrick Tang, Ted Steiner, Michael Otterstater, Rob Holt, Richard Moore, Charles Y Chiu, David M Patrick
Background: Chronic fatigue syndrome (CFS) remains poorly understood. Although infections are speculated to trigger the syndrome, a specific infectious agent and underlying pathophysiological mechanism remain elusive. In a previous study, we described similar clinical phenotypes in CFS patients and alternatively diagnosed chronic Lyme syndrome (ADCLS) patients—individuals diagnosed with Lyme disease by testing from private Lyme specialty laboratories but who test negative by reference 2-tiered serologic analysis...
February 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28131842/mcf7-microtubules-cancer-microtubules-with-relatively-slow-and-stable-dynamic-in-vitro
#18
Mitra Shojania Feizabadi, Brandon Rosario
There is known to be significant diversity of β-tubulin isoforms in cells. However, whether the functions of microtubules that are polymerized from different distributions of beta isotypes become distinct from one another are still being explored. Of particular interest, recent studies have identified the role that different beta tubulin isotypes carry in regulating the functions of some of the molecular motors along MCF7, or breast cancer, microtubules. That being said, how the specific distribution of beta tubulin isotypes impacts the MCF7 microtubules' dynamic is not well understood...
March 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28040245/the-rising-prevalence-and-incidence-of-gout-in-british-columbia-canada-population-based-trends-from-2000-to-2012
#19
Sharan K Rai, J Antonio Aviña-Zubieta, Natalie McCormick, Mary A De Vera, Kam Shojania, Eric C Sayre, Hyon K Choi
OBJECTIVES: Gout is increasingly recognized as the most common form of inflammatory arthritis worldwide; however, no Canadian data on the disease burden of gout are available. We estimated the prevalence, incidence, prescription patterns, and comorbidity burden of gout in an entire Canadian province [British Columbia (BC)] over the last decade. METHODS: We utilized PopulationData BC, a province-wide database, to estimate temporal trends in the prevalence and incidence of gout from 2000 to 2012, as well as according to age category...
February 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/27986900/a-primer-on-pdsa-executing-plan-do-study-act-cycles-in-practice-not-just-in-name
#20
Jerome A Leis, Kaveh G Shojania
No abstract text is available yet for this article.
July 2017: BMJ Quality & Safety
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