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Adult acne

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https://www.readbyqxmd.com/read/28707712/acne-prevalence-and-associations-with-lifestyle-a-cross-sectional-online-survey-of-adolescents-young-adults-in-7-european-countries
#1
P Wolkenstein, A Machovcová, J C Szepietowski, D Tennstedt, S Veraldi, A Delarue
BACKGROUND: Although acne vulgaris is a common skin disorder, limited epidemiological data exist specifically for European populations. OBJECTIVE: To determine the prevalence of self-reported acne among young people in Europe and evaluate the effect of lifestyle on acne. METHODS: We conducted a cross-sectional population-based online survey in representative samples of individuals aged 15-24 years in Belgium, Czech and Slovak Republics, France, Italy, Poland and Spain (n=10,521), identified by a quota sampling method based on age, geographic location, and socio-professional category...
July 14, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28686771/fixed-combination-of-clindamycin-phosphate-1-2-and-benzoyl-peroxide-3-75-aqueous-gel-long-term-use-in-adult-females-with-moderate-acne-vulgaris
#2
Leon H Kircik
<p>OBJECTIVE: To evaluate long-term efficacy and safety of a fixed combination clindamycin phosphate 1.2% and benzoyl peroxide 3.75% (Clindamycin-BP 3.75%) aqueous gel in adult female patients with moderate acne vulgaris.</p> <p>METHODS: Total of 20 patients, 25-63 years of age (mean [SD], 38 ± 10) with moderate acne (IGA=3) were treated with Clindamycin-BP 3.75% once-daily for 12 weeks. Patients who experienced ≥50% reduction in total lesion count continued treatment for a further 12 weeks...
June 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28686770/the-efficacy-and-safety-of-azelaic-acid-15-foam-in-the-treatment-of-truncal-acne-vulgaris
#3
Lauren K Hoffman, James Q Del Rosso, Leon H Kircik
<p>INTRODUCTION: Truncal acne is often associated with facial acne, but there are fewer options for an effective topical treatment on the trunk. Given the advent of foam formulations with enhanced percutaneous absorption and convenient application due to easy spreadability on skin, the previously held idea that effective treatment of truncal acne requires oral treatment is challenged. Azelaic acid cream has been previously approved for acne vulgaris, thus azelaic acid foam may be a viable treatment option for truncal acne...
June 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28681230/probiotics-prebiotics-and-synbiotics-for-the-treatment-and-prevention-of-adult-dermatological-diseases
#4
REVIEW
Manisha Notay, Negar Foolad, Alexandra R Vaughn, Raja K Sivamani
BACKGROUND: Probiotic, prebiotic, and synbiotic supplementation is becoming more prevalent nowadays. Clinical studies have demonstrated some of the medical benefits of probiotics, prebiotics, and synbiotics within dermatology but an evidence-based review of their effects in adults is needed. OBJECTIVE: The aim of this study was to identify evidence for the use of supplementation with probiotics, prebiotics, or synbiotics for the prevention and treatment of dermatological diseases in adults...
July 5, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28670354/psychosocial-impact-of-postinflammatory-hyperpigmentation-in-patients-with-acne-vulgaris
#5
Kavita Darji, Reena Varade, Daniel West, Eric S Armbrecht, Mary A Guo
Background: Acne vulgaris is a common, often socially distressing skin condition primarily seen in young adults. Quality of life studies have shown that people with acne are more introverted with increased social setting anxiety compared to a control group. Unfortunately, patients with acne may have residual postinflammatory hyperpigmentation, amplifying impaired psychosocial effects. Objective: To quantify the impact of postinflammatory hyperpigmentation in patients with acne using a psychometric scale. Design: A clinic-based survey was conducted among US adults with facial acne and postinflammatory hyperpigmentation...
May 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28664654/acne-keloidalis-nuchae-risk-factors-and-associated-disorders-a-retrospective-study
#6
Althea D C East-Innis, Kaderina Stylianou, Alexandra Paolino, Jonathan D Ho
BACKGROUND: Acne keloidalis nuchae (AKN) is a chronic scarring folliculitis which usually occurs in young adult males of African descent. Studies have suggested that AKN may be associated with other dermatologic conditions and even general medical disorders. The aim of this study was to identify cutaneous and extracutaneous associated disorders and to examine risk factors in our population for developing AKN. METHODS: The study was a retrospective, descriptive, and analytical study conducted at the Dermatology Outpatient department of the University Hospital of the West Indies...
June 30, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28662301/multiple-miliary-osteoma-cutis-an-overlooked-dermatosis
#7
B Duarte, R R Pinheiro, J Cabete
A 63-year-old, skin type V woman presented with a 3-year history of multiple asymptomatic papules on the face, which were slowly increasing in number and causing cosmetic concerns. These lesions had been interpreted as adult acne, and for the past two years she had been treated with topical and systemic retinoids and submitted to a salicylic acid peel without benefit. She had no prior history of acne and her medical past was unremarkable. Regular medication or other facial treatments were denied. This article is protected by copyright...
June 29, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28653345/treatment-of-sarcopenia-with-bimagrumab-results-from-a-phase-ii-randomized-controlled-proof-of-concept-study
#8
Daniel Rooks, Jens Praestgaard, Sam Hariry, Didier Laurent, Olivier Petricoul, Robert G Perry, Estelle Lach-Trifilieff, Ronenn Roubenoff
OBJECTIVES: To assess the effects of bimagrumab on skeletal muscle mass and function in older adults with sarcopenia and mobility limitations. DESIGN: A 24-week, randomized, double-blind, placebo-controlled, parallel-arm, proof-of-concept study. SETTING: Five centers in the United States. PARTICIPANTS: Community-dwelling adults (N = 40) aged 65 and older with gait speed between 0.4 and 1.0 m/s over 4 m and an appendicular skeletal muscle index of 7...
June 27, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28606553/differences-in-dietary-glycemic-load-and-hormones-in-new-york-city-adults-with-no-and-moderate-severe-acne
#9
Jennifer Burris, William Rietkerk, James M Shikany, Kathleen Woolf
BACKGROUND: Glycemic index (GI) and glycemic load (GL) may be implicated in acne pathogenesis. OBJECTIVE: This cross-sectional study examined differences between GI/GL and biological factors associated with acne among adults with and without moderate/severe acne. Secondary objectives included examining differences between food-aggravated acne beliefs and acne-specific quality of life among adults with and without moderate/severe acne. DESIGN: As part of a cross-sectional study, participants completed a 5-day food record; blood draw to measure biological factors associated with acne (ie, glucose, insulin, insulin-like growth factor-1, insulin-like growth factor binding protein-3, and sex hormone-binding globulin concentrations); body composition assessment; and questionnaire to evaluate food-aggravated acne beliefs and acne-specific quality of life...
June 9, 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28573779/a-skincare-combined-with-fixed-adapalene-and-benzoyl-peroxide-combination-provides-a-significant-adjunctive-efficacy-and-local-tolerance-benefit-in-adult-women-with-mild-acne
#10
A Bouloc, E Roo, B Imko-Walczuk, A Moga, B Chadoutaud, B Dréno
INTRODUCTION: Acne in adult women is an increasing reason for dermatological consultations. OBJECTIVE: The aim of this study was to assess in adult women with mild acne the efficacy and tolerance of a daily adjunctive application of a skincare (Normaderm(®) , Laboratoires Vichy, France) to a fixed combination of adapalene/benzoyl peroxide daily or every other evening and a standard emollient. METHODS: Subjects were randomised to receive the fixed combination applied either every evening or every other evening and a daily application of the standard emollient and the test care or a once daily application of the fixed combination and the standard emollient alone...
June 2, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28533848/dermatology-in-ghana-a-retrospective-review-of-skin-disease-at-the-korle-bu-teaching-hospital-dermatology-clinic
#11
Brooke E Rosenbaum, Rebecca Klein, Paa Gyasi Hagan, Mark-Young Seadey, Naa Larteley Quarcoo, Rachel Hoffmann, Maria Robinson, Margaret Lartey, Marie C Leger
INTRODUCTION: Ghana is currently developing its provision of dermatology services. Epidemiologic studies of the skin diseases seen by Ghanaian dermatologists are needed to guide these efforts. We aimed to describe the skin conditions seen by and management practices of Ghanaian dermatologists in a specialized clinic. METHODS: We conducted a chart review of new patients presenting to the Korle Bu Teaching Hospital dermatology clinic during 2014. RESULTS: Among the 529 patients studied, 700 discrete diagnoses were made...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28511829/suicidal-behaviors-in-the-dermatology-patient
#12
Madhulika A Gupta, Daiana R Pur, Branka Vujcic, Aditya K Gupta
An assessment of suicidal behaviors in the dermatology patient may be necessary in several situations: (1) in the presence of psychiatric comorbidity (major depressive disorder, body dysmorphic disorder, substance use disorder, posttraumatic stress disorder), encountered in up to 30% of dermatology patients; (2) when dermatologic symptoms ("dysmorphophobia," dermatitis artefacta) represent psychiatric pathologic conditions; (3) when psychosocial stressors (bereavement, interpersonal violence) increase the risk of suicidal behavior and exacerbate stress-reactive dermatoses (psoriasis, acne); (4) in the presence of high disease burden (chronicity, increased disease severity); (5) in instances of significant pruritus or chronic sleep disruption; (6) in the presence of facial lesions or facial scarring; (7) when social exclusion or feelings of alienation arise secondary to the skin disorder; (8) with use of medications (retinoids, biologics) for which suicidal behavior has been implicated as a possible side effect; and (9) when treating psychiatric patients experiencing a serious reaction to psychotropic medications (eg, Stevens-Johnson syndrome and anticonvulsants)...
May 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28499079/development-of-an-atrophic-acne-scar-risk-assessment-tool
#13
J Tan, D Thiboutot, H Gollnick, S Kang, A Layton, J J Leyden, V Torres, J Guillemot, B Dréno
BACKGROUND: Acne is a chronic dermatological disease predominantly afflicting young adults and is often associated with the development of scars. Acne scarring is usually avoidable when acne is managed early and effectively. However, acne patients often fail to seek early treatment. New and innovative tools to raise awareness are needed. OBJECTIVE: This study presents the development and assessment of a tool aiming to assess the risk of atrophic acne scars. METHODS: A systematic literature review of clinical risk factors for acne scars, a Delphi-like survey of dermatological experts in acne and secondary data analysis were conducted in order to produce an evidence-based risk assessment tool...
May 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28497664/insulin-sensitizers-in-adolescents-with-polycystic-ovary-syndrome
#14
Trang N LE, Edmond P Wickham Iii, John E Nestler
Polycystic ovary syndrome (PCOS) is the most common disorder of androgen excess in women of reproductive age. The diagnosis of PCOS can be more challenging in adolescents than in adult women given significant overlap between normal puberty and the signs of PCOS, including acne, menstrual irregularity, and polycystic ovarian morphology. Optimal treatments for adult women with PCOS vary depending on patient risk factors and reproductive goals, but mainly include hormonal contraception and insulin sensitizers...
May 11, 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/28492054/a-review-of-hormone-based-therapies-to-treat-adult-acne-vulgaris-in-women
#15
REVIEW
M K Trivedi, K Shinkai, J E Murase
Hormone-based therapies including combined oral contraceptive medications and spironolactone are considered effective therapies to treat adult acne in women. Our objective is to provide a concise and comprehensive overview of the types of hormonal therapy that are available to treat acne and comment on their efficacy and safety profiles for clinical practice. A systematic search using the PubMed Database was conducted to yield 36 relevant studies for inclusion in the review and several conclusions were drawn from the literature...
March 2017: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/28489484/factors-affecting-the-course-and-severity-of-adult-acne-observational-cohort-study
#16
Ewa Chlebus, Marcin Chlebus
OBJECTIVE: To identify factors improving symptoms and shortening duration of AA. MATERIAL AND METHODS: The observational cohort study was performed in 111 patients with AA (>25 y.o.) in 2015-2016. Clinical manifestation, previous treatments, environmental risk factors and features of juvenile acne affecting AA were assessed. RESULTS: The maximum severity of persistent acne was significantly lower after 25 years of age, as compared to adolescence (7...
May 31, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28391505/bacterial-communities-on-facial-skin-of-teenage-and-elderly-thai-females
#17
Naraporn Somboonna, Alisa Wilantho, Chutika Srisuttiyakorn, Anunchai Assawamakin, Sissades Tongsima
The Human Microbiome Project was first established to understand the roles of human-associated microbes to human health and disease. This study presents preliminary findings of Thai female facial skin microbiome using three pooled samples from groups of skin microbiome profiles, namely (1) healthy and (2) acne-prone young adults (teenage.hea and teenage.acn) and (3) healthy elderly adults (elderly.hea) based on standard dermatological criteria. These samples were sequenced using 454-pyrosequencing targeting 16S rRNA (V3-V4 regions)...
April 8, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/28386469/propionibacterium-acnes-phylogenetic-type-iii-is-associated-with-progressive-macular-hypomelanosis
#18
Rolf L W Petersen, Christian F P Scholz, Anders Jensen, Holger Brüggemann, Hans B Lomholt
Progressive macular hypomelanosis (PMH) is a skin disorder that is characterized by hypopigmented macules and usually seen in young adults. The skin microbiota, in particular the bacterium Propionibacterium acnes, is suggested to play a role. Here, we compared the P. acnes population of 24 PMH lesions from eight patients with corresponding nonlesional skin of the patients and matching control samples from eight healthy individuals using an unbiased, culture-independent next-generation sequencing approach. We also compared the P...
March 2017: European Journal of Microbiology & Immunology
https://www.readbyqxmd.com/read/28373256/patient-perceptions-of-glucocorticoid-side-effects-a-cross-sectional-survey-of-users-in-an-online-health-community
#19
Ruth Costello, Rikesh Patel, Jennifer Humphreys, John McBeth, William G Dixon
OBJECTIVES: To identify the side effects most important to glucocorticoid (GC) users through a survey of a UK online health community (Healthunlocked.com). DESIGN: Online cross-sectional survey. SETTING: Participants were recruited through Healthunlocked.com, an online social network for health. PARTICIPANTS: Adults who were currently taking GCs, or had taken GCs in the past month. METHOD: Responders scored the importance of listed side effects from 1 to 10, with 10 being of high importance to them...
April 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/28342238/a-peel-off-facial-mask-comprising-myoinositol-and-trehalose-loaded-liposomes-improves-adult-female-acne-by-reducing-local-hyperandrogenism-and-activating-autophagy
#20
Gabriella Fabbrocini, Claudia Capasso, Marianna Donnarumma, Mariateresa Cantelli, Michel Le Maître, Giuseppe Monfrecola, Enzo Emanuele
BACKGROUND: Hyperandrogenism and reduced skin autophagy have been implicated in the pathogenesis of adult female acne (AFA). Here, we tested whether a ready-to-use peel-off facial mask containing myoinositol (an androgen inhibitor) and trehalose-loaded liposomes (as activators of cutaneous autophagy) applied overnight every other day for 60 days can improve AFA. We also sought to investigate the molecular mechanisms underlying the clinical effects. OBJECTIVES: We conducted an uncontrolled, open-label clinical study in 40 cases of AFA to investigate the effect of the facial mask on lesion count, sebum production (measured with the Sebutape® technique), and Global Acne Grading System (GAGS) scale...
March 25, 2017: Journal of Cosmetic Dermatology
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