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Adult acne

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https://www.readbyqxmd.com/read/29024079/the-preadolescent-acne-microbiome-a-prospective-randomized-pilot-study-investigating-characterization-and-effects-of-acne-therapy
#1
Carrie C Coughlin, Shane M Swink, Joseph Horwinski, Georgia Sfyroera, Julia Bugayev, Elizabeth A Grice, Albert C Yan
BACKGROUND/OBJECTIVES: Acne, a common pediatric disease, tends to be more comedonal in preadolescents, whereas older individuals are more likely to have inflammatory lesions in addition to comedones. Thus the microbiome of preadolescents may be different. In this pilot study we aimed to characterize the preadolescent acne microbiome, compare the microbiome in preadolescents with and without acne, and investigate changes in the microbiome after topical treatment with benzoyl peroxide or a retinoid in a small cohort of preadolescents...
October 11, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29024049/a-cross-sectional-study-of-the-perceptions-about-triggering-factors-in-acne-patients
#2
Clio Dessinioti, Eftychia Platsidaki, Chrisa Zisimou, Vasiliki Tzanetakou, Andreas Katsambas, Christina Antoniou
Acne is a common, inflammatory skin disease of the pilosebaceous unit.(1) Patients often have misconceptions about factors exacerbating acne that may influence their treatment seeking behavior. We conducted a cross-sectional study to investigate the perceptions of patients with acne about triggering factors, and how they may differ among adults and adolescents. This article is protected by copyright. All rights reserved.
October 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28990222/managing-acne-in-the-middle-east-consensus-recommendations
#3
REVIEW
H Gollnick, A A Abanmi, M Al-Enezi, A Al Hammadi, I Galadari, A-G Kibbi, S Zimmo
Acne has been estimated to affect the majority of people at some point in their life and is common in Middle Eastern countries. While acne is frequently perceived to be a self-limited disease of adolescence, there is an increasing population of adults with acne. Information about the management of acne in the Middle East is somewhat sparse; however, several studies have recently been conducted and will be discussed in this supplement.
November 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28979696/effects-of-acrylonitrile-induced-oxidative-stress-on-testicular-apoptosis-through-activation-of-nf-%C3%AE%C2%BAb-signaling-pathway-in-male-sprague-dawley-rats
#4
Yuhui Dang, Qianlong Zhao, Boyan Luo, Li Pan, Qian Wei, Ruiping Zhang, Qiaorong Fan, Junyi Chen, Ruixia Chang, Jie Zhang, Zhilan Li
Acrylonitrile (ACN) treatment can induce testicular toxicity in Sprague-Dawley (SD) rats, with the toxicity potentially related to apoptosis, mediated by nuclear factor-κB (NF-κB). The present study investigated the potential role of NF-κB in the induction of apoptosis and testicular toxicity in ACN-treated rats. Adult male SD rats were randomly divided into 3 treatment groups: a control group (corn oil), an ACN group (50 mg/kg) in which ACN was administered by gavage, and an ACN and N-acetylcysteine (ACN+NAC) group...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28972874/impact-of-sequential-culture-results-on-diagnosis-and-de-escalation-of-the-antibiotic-regimen-in-joint-and-bone-infections
#5
Solen Kernéis, Cécile Leprince, Denis Archambeau, Luc Eyrolle, Philippe Leclerc, Hélène Poupet, Julien Loubinoux, Rémy Gauzit, Dominique Salmon, Odile Launay, Claire Poyart, Philippe Anract, Philippe C Morand
BACKGROUND: According to existing guidelines, orthopedic specimens collected in joint and bone infections (JBI) in our institution are cultured on several media sets and incubated for two, seven, and 14 days. The optimal timing for de-escalation of the first-line antibiotic combination according to the culture results needs to be defined. METHODS: Single-center, retrospective analysis of all adult patients with a first documented episode of JBI between May 2012 and April 2013...
October 3, 2017: Surgical Infections
https://www.readbyqxmd.com/read/28915843/protective-effects-of-gaba-against-metabolic-and-reproductive-disturbances-in-letrozole-induced-polycystic-ovarian-syndrome-in-rats
#6
Asad Ullah, Sarwat Jahan, Suhail Razak, Madeeha Pirzada, Hizb Ullah, Ali Almajwal, Naveed Rauf, Tayyaba Afsar
BACKGROUND: PCOs is a heterogeneous disorder with anovulation/oligo ovulation usually taken as oligo menorrhoea or amenorrhoea, hyperandrogenemia, hirsutism, acne, androgen alopecia and polycystic ovaries as the key diagnostic feathers. The study was undertaken to investigate the possible protective and ameliorating effects of GABA in Letrozole induced PCOS model in rats by targeting insulin resistance. METHODS: PCOs in Adult female rat was induced by the daily gastric administration of letrozole (1 mg/kg/day) in CMC (0...
September 15, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28912911/doxycycline-induced-acute-pancreatitis-a-rare-adverse-event
#7
Prashanth Rawla, Jeffrey Pradeep Raj
Doxycycline is a broad-spectrum antibiotic belonging to the tetracycline group which acts by inhibiting bacterial protein synthesis. It is considered to be a relatively safe drug. We report a case of doxycycline-induced acute pancreatitis (DIAP) in an adult female patient who was started on the usual therapeutic dose 1 week before for acne vulgaris. The WHO causality assessment was possible, and the Naranjo scale confirmed it as "definite" adverse drug reaction. A brief literature review on case reports previously reporting DIAP has also been summarized...
August 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/28873105/hair-and-scalp-disorders-in-adult-and-pediatric-patients-with-skin-of-color
#8
Susan C Taylor, Victoria Barbosa, Cheryl Burgess, Candrice Heath, Amy J McMichael, Temitayo Ogunleye, Valerie Callender
As increasing numbers of patients of African descent seek treatment for hair and scalp-related diseases, it is imperative that all dermatologists be adequately trained to address the concerns of this patient population. We present must-know information to effectively approach the concerns of patients with seborrheic dermatitis, acquired trichorrhexis nodosa, acne keloidalis nuchae, pseudofolliculitis barbae, alopecia, and common pediatric hair and scalp disorders.
July 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28862134/adult-female-acne-treated-with-spironolactone-a-retrospective-data-review-of-70-cases
#9
Anne Isvy-Joubert, Jean-Michel Nguyen, Aurélie Gaultier, Mélanie Saint-Jean, Marie Le Moigne, Elodie Boisrobert, Amir Khammari, Brigitte Dreno
The prevalence of acne in the adult population is increasing, particularly in women. Spironolactone regulates sebaceous gland activity by blocking androgen receptor. To evaluate retrospectively the efficacy of spironolactone in women with acne. Data from 70 women of at least 20 years, treated for their acne between 2010 and 2015 with low-dose spironolactone (≤150 mg/day), were analysed. Remission was defined by the number of retentional lesions inferior or equal to five and inflammatory lesions inferior or equal to two on the face...
August 1, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28768538/pulsed-radiofrequency-or-anterior-neurectomy-for-anterior-cutaneous-nerve-entrapment-syndrome-acnes-the-pulse-trial-study-protocol-of-a-randomized-controlled-trial
#10
Robbert C Maatman, Monique A H Steegers, Oliver B A Boelens, Toine C Lim, Hans J van den Berg, Sandra A S van den Heuvel, Marc R M Scheltinga, Rudi M H Roumen
BACKGROUND: Some patients with chronic abdominal pain suffer from an anterior cutaneous nerve entrapment syndrome (ACNES). This somewhat illusive syndrome is thought to be caused by the entrapment of end branches of the intercostal nerves residing in the abdominal wall. If ACNES is suspected, a local injection of an anesthetic agent may offer relief. If pain is recurrent following multiple-injection therapy, an anterior neurectomy entailing removal of the entrapped nerve endings may be considered...
August 2, 2017: Trials
https://www.readbyqxmd.com/read/28707712/acne-prevalence-and-associations-with-lifestyle-a-cross-sectional-online-survey-of-adolescents-young-adults-in-7-european-countries
#11
P Wolkenstein, A Machovcová, J C Szepietowski, D Tennstedt, S Veraldi, A Delarue
BACKGROUND: Although acne vulgaris is a common skin disorder, limited epidemiological data exist specifically for European populations. OBJECTIVE: To determine the prevalence of self-reported acne among young people in Europe and evaluate the effect of lifestyle on acne. METHODS: We conducted a cross-sectional population-based online survey in representative samples of individuals aged 15-24 years in Belgium, Czech and Slovak Republics, France, Italy, Poland and Spain (n=10,521), identified by a quota sampling method based on age, geographic location, and socio-professional category...
July 14, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28686771/fixed-combination-of-clindamycin-phosphate-1-2-and-benzoyl-peroxide-3-75-aqueous-gel-long-term-use-in-adult-females-with-moderate-acne-vulgaris
#12
Leon H Kircik
<p>OBJECTIVE: To evaluate long-term efficacy and safety of a fixed combination clindamycin phosphate 1.2% and benzoyl peroxide 3.75% (Clindamycin-BP 3.75%) aqueous gel in adult female patients with moderate acne vulgaris.</p> <p>METHODS: Total of 20 patients, 25-63 years of age (mean [SD], 38 ± 10) with moderate acne (IGA=3) were treated with Clindamycin-BP 3.75% once-daily for 12 weeks. Patients who experienced ≥50% reduction in total lesion count continued treatment for a further 12 weeks...
June 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28686770/the-efficacy-and-safety-of-azelaic-acid-15-foam-in-the-treatment-of-truncal-acne-vulgaris
#13
Lauren K Hoffman, James Q Del Rosso, Leon H Kircik
<p>INTRODUCTION: Truncal acne is often associated with facial acne, but there are fewer options for an effective topical treatment on the trunk. Given the advent of foam formulations with enhanced percutaneous absorption and convenient application due to easy spreadability on skin, the previously held idea that effective treatment of truncal acne requires oral treatment is challenged. Azelaic acid cream has been previously approved for acne vulgaris, thus azelaic acid foam may be a viable treatment option for truncal acne...
June 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28681230/probiotics-prebiotics-and-synbiotics-for-the-treatment-and-prevention-of-adult-dermatological-diseases
#14
REVIEW
Manisha Notay, Negar Foolad, Alexandra R Vaughn, Raja K Sivamani
BACKGROUND: Probiotic, prebiotic, and synbiotic supplementation is becoming more prevalent nowadays. Clinical studies have demonstrated some of the medical benefits of probiotics, prebiotics, and synbiotics within dermatology but an evidence-based review of their effects in adults is needed. OBJECTIVE: The aim of this study was to identify evidence for the use of supplementation with probiotics, prebiotics, or synbiotics for the prevention and treatment of dermatological diseases in adults...
July 5, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28670354/psychosocial-impact-of-postinflammatory-hyperpigmentation-in-patients-with-acne-vulgaris
#15
Kavita Darji, Reena Varade, Daniel West, Eric S Armbrecht, Mary A Guo
Background: Acne vulgaris is a common, often socially distressing skin condition primarily seen in young adults. Quality of life studies have shown that people with acne are more introverted with increased social setting anxiety compared to a control group. Unfortunately, patients with acne may have residual postinflammatory hyperpigmentation, amplifying impaired psychosocial effects. Objective: To quantify the impact of postinflammatory hyperpigmentation in patients with acne using a psychometric scale. Design: A clinic-based survey was conducted among US adults with facial acne and postinflammatory hyperpigmentation...
May 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28664654/acne-keloidalis-nuchae-risk-factors-and-associated-disorders-a-retrospective-study
#16
Althea D C East-Innis, Kaderina Stylianou, Alexandra Paolino, Jonathan D Ho
BACKGROUND: Acne keloidalis nuchae (AKN) is a chronic scarring folliculitis which usually occurs in young adult males of African descent. Studies have suggested that AKN may be associated with other dermatologic conditions and even general medical disorders. The aim of this study was to identify cutaneous and extracutaneous associated disorders and to examine risk factors in our population for developing AKN. METHODS: The study was a retrospective, descriptive, and analytical study conducted at the Dermatology Outpatient department of the University Hospital of the West Indies...
August 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28662301/multiple-miliary-osteoma-cutis-an-overlooked-dermatosis
#17
LETTER
B Duarte, R R Pinheiro, J Cabete
No abstract text is available yet for this article.
June 29, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28653345/treatment-of-sarcopenia-with-bimagrumab-results-from-a-phase-ii-randomized-controlled-proof-of-concept-study
#18
RANDOMIZED CONTROLLED TRIAL
Daniel Rooks, Jens Praestgaard, Sam Hariry, Didier Laurent, Olivier Petricoul, Robert G Perry, Estelle Lach-Trifilieff, Ronenn Roubenoff
OBJECTIVES: To assess the effects of bimagrumab on skeletal muscle mass and function in older adults with sarcopenia and mobility limitations. DESIGN: A 24-week, randomized, double-blind, placebo-controlled, parallel-arm, proof-of-concept study. SETTING: Five centers in the United States. PARTICIPANTS: Community-dwelling adults (N = 40) aged 65 and older with gait speed between 0.4 and 1.0 m/s over 4 m and an appendicular skeletal muscle index of 7...
September 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28606553/differences-in-dietary-glycemic-load-and-hormones-in-new-york-city-adults-with-no-and-moderate-severe-acne
#19
Jennifer Burris, William Rietkerk, James M Shikany, Kathleen Woolf
BACKGROUND: Glycemic index (GI) and glycemic load (GL) may be implicated in acne pathogenesis. OBJECTIVE: This cross-sectional study examined differences between GI/GL and biological factors associated with acne among adults with and without moderate/severe acne. Secondary objectives included examining differences between food-aggravated acne beliefs and acne-specific quality of life among adults with and without moderate/severe acne. DESIGN: As part of a cross-sectional study, participants completed a 5-day food record; blood draw to measure biological factors associated with acne (ie, glucose, insulin, insulin-like growth factor-1, insulin-like growth factor binding protein-3, and sex hormone-binding globulin concentrations); body composition assessment; and questionnaire to evaluate food-aggravated acne beliefs and acne-specific quality of life...
September 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28573779/a-skincare-combined-with-combination-of-adapalene-and-benzoyl-peroxide-provides-a-significant-adjunctive-efficacy-and-local-tolerance-benefit-in-adult-women-with-mild-acne
#20
A Bouloc, E Roo, B Imko-Walczuk, A Moga, B Chadoutaud, B Dréno
INTRODUCTION: Acne in adult women is an increasing reason for dermatological consultations. OBJECTIVE: The aim of this study was to assess in adult women with mild acne the efficacy and tolerance of a daily adjunctive application of a skincare (Normaderm(®) , Laboratoires Vichy, France) to a fixed combination of adapalene/benzoyl peroxide daily or every other evening and a standard emollient. METHODS: Subjects were randomized to receive the fixed combination applied either every evening or every other evening and a daily application of the standard emollient and the test care or a once daily application of the fixed combination and the standard emollient alone...
June 2, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
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