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https://www.readbyqxmd.com/read/27921251/skin-manifestations-of-insulin-resistance-from-a-biochemical-stance-to-a-clinical-diagnosis-and-management
#1
REVIEW
Gloria González-Saldivar, René Rodríguez-Gutiérrez, Jorge Ocampo-Candiani, José Gerardo González-González, Minerva Gómez-Flores
Worldwide, more than 1.9 billion adults are overweight, and around 600 million people suffer from obesity. Similarly, ~382 million individuals live with diabetes, and 40-50% of the global population is labeled at "high risk" (i.e., prediabetes). The impact of these two chronic conditions relies not only on the burden of illnesses per se (i.e., associated increased morbidity and mortality), but also on their increased cost, burden of treatment, and decreased health-related quality of life. For this review a comprehensive search in several databases including PubMed (MEDLINE), Ovid EMBASE, Web of Science, and Scopus was conducted...
December 5, 2016: Dermatology and Therapy
https://www.readbyqxmd.com/read/27904178/topical-steroid-awareness-and-abuse-a-prospective-study-among-dermatology-outpatients
#2
T S Nagesh, A Akhilesh
BACKGROUND: Topical steroids are one of the most commonly abused drugs. There are only a few studies available which have highlighted the severity of this problem in India. However, these studies have concentrated mainly on the topical steroid abuse and its side effects over the face. AIMS: The aim of this study was to know the awareness among the people about various commonly available topical steroids and their combinations irrespective of usage and to know the extent of misuse of these drugs...
November 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27897372/azelaic-acid-20%C3%A2-cream-effects-on-quality-of-life-and-disease-severity-in-adult-female-acne-patients
#3
Julius Thomas Kainz, Gabriele Berghammer, Piet Auer-Grumbach, Verena Lackner, Sylvia Perl-Convalexius, Rodica Popa, Barbara Wolfesberger
BACKGROUND: Data on the efficacy of acne treatments and their impact on quality of life (QoL) in adult patients is sketchy. OBJECTIVE: Assessment of the efficacy of azelaic acid 20 % cream (Skinoren(®) ) on acne severity and disease-related QoL. PATIENTS AND METHODS: Noninterventional study in adult female patients with mild to moderate acne. Efficacy variables included DLQI and acne severity on the face, chest, and back using the Investigator's Global Assessment (IGA) scale (grade 1 = nearly clear skin; 2 = mild acne; 3 = moderate acne)...
November 29, 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27869372/pathogenesis-and-clinical-presentation-of-rosacea-as-a-key-for-a-symptom-oriented-therapy
#4
M Reinholz, T Ruzicka, M Steinhoff, M Schaller, U Gieler, H Schöfer, B Homey, P Lehmann, T A Luger
Rosacea is a common chronic inflammatory skin disorder that typically occurs in adults and affects the face. Synonyms of rosacea include "acne rosacea", "couperose" and "facial erythrosis", in German also "Kupferfinne" and "Rotfinne". The disorder is characterised by a chronic and flaring course and is caused by a genetically predisposed, multifactorial process. A higher incidence is seen in people with fair skin and a positive family history. The characteristic rosacea symptoms manifest primarily, but not exclusively centrofacially, with forehead, nose, chin and cheeks significantly affected...
December 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27790756/adapalene-0-1-benzoyl-peroxide-2-5-gel-reduces-the-risk-of-atrophic-scar-formation-in-moderate-inflammatory-acne-a-split-face-randomized-controlled-trial
#5
B Dreno, J Tan, M Rivier, P Martel, R Bissonnette
BACKGROUND: The efficacy of current topical acne treatments in mitigating the potential for acne scarring is not known. OBJECTIVE: To evaluate the effect of adapalene 0.1%/benzoyl peroxide 2.5% (A/BPO) gel compared to vehicle in reducing the risk of acne scarring. METHODS: Multicentre, randomized, investigator-blinded, vehicle-controlled, split-face study conducted over 6 months. Subjects were adults with active moderate facial acne vulgaris and at least 10 atrophic acne scars at baseline...
October 28, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27790755/analysis-of-korean-acne-patients-according-to-age-groups-based-on-two-multicenter-studies
#6
Mi Youn Park, Kyung Ho Kim, Hoon Kang, Young Chul Kye, Hyuck Hoon Kwon, Kwang Joong Kim, Nack In Kim, Myeung Nam Kim, Young Suck Ro, Seonguk Min, Kui Young Park, Margaret Song, Kyu Joong Ahn, Hyo Hyun Ahn, Mi Woo Lee, Weon Ju Lee, Jee Bum Lee, Yu Sung Choi, Dae Hun Suh
Along with increasing public concerns on acne and its complications, increasing treatment options seem to lead more acne patients to clinics globally, including Korea. The aim of the present study was to investigate the number and distribution of acne patients according to age group by analyzing number and age of outpatients from several general hospitals in Korea. Two retrospective multicenter studies including 14 general hospitals for a maximum of 10 years were conducted by medical chart review of acne patients...
October 28, 2016: Journal of Dermatology
https://www.readbyqxmd.com/read/27749646/epidemiology-of-acne-vulgaris-in-adolescent-male-students-in-arar-kingdom-of-saudi-arabia
#7
Nagah M Abo El-Fetoh, Naif G Alenezi, Nasser G Alshamari, Omar G Alenezi
BACKGROUND: Acne vulgaris is the most common cutaneous disorder affecting adolescents and young adults. Small, noninflamed acne lesions may not be more than a slight nuisance, but, in individuals with more severe inflammatory disease, pain, social embarrassment, and both physical and psychological scarring can be life altering. Despite its high prevalence, no previous community-based studies have been conducted in Arar, northern border of Kingdom of Saudi Arabia, addressing this issue...
September 2016: Journal of the Egyptian Public Health Association
https://www.readbyqxmd.com/read/27741552/adult-body-size-sexual-history-and-adolescent-sexual-development-may-predict-risk-of-developing-prostate-cancer-results-from-the-new-south-wales-lifestyle-and-evaluation-of-risk-study-clear
#8
Visalini Nair-Shalliker, Sarsha Yap, Carlos Nunez, Sam Egger, Jennifer Rodger, Manish I Patel, Dianne L O'Connell, Freddy Sitas, Bruce K Armstrong, David P Smith
Prostate cancer (PC) is the most common non-cutaneous cancer in men worldwide. The relationships between PC and possible risk factors for PC cases (n = 1,181) and male controls (n = 875) from the New South Wales (NSW) Cancer, Lifestyle and Evaluation of Risk Study (CLEAR) were examined in this study. The associations between PC risk and paternal history of PC, body mass index (BMI), medical conditions, sexual behaviour, balding pattern and puberty, after adjusting for age, income, region of birth, place of residence, and PSA testing, were examined...
October 14, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27738425/profile-of-skin-disorders-in-unreached-hilly-areas-of-north-india
#9
Deepak Dimri, Venkatashiva Reddy B, Amit Kumar Singh
Background. The pattern of skin morbidity in an area depends on climate, geography, socioeconomic status, nutrition, genetics, and habits of the community. Objective. The objective of the present study was to describe the morbidity profile of patients attending dermatology outpatient department in a tertiary care centre of Garhwal hills, North India. Methodology. This is a record based study carried out using the morbidity registers. Patient details, diagnosis, and treatment provided by physicians were documented in the morbidity register...
2016: Dermatology Research and Practice
https://www.readbyqxmd.com/read/27699861/pediatric-pyoderma-gangrenosum-a-retrospective-review-of-clinical-features-etiologic-associations-and-treatment
#10
Jennifer J Schoch, Stanislav N Tolkachjov, Jonathan A Cappel, Lawrence E Gibson, Dawn Marie R Davis
BACKGROUND/OBJECTIVES: Pyoderma gangrenosum (PG) is a neutrophilic dermatosis rarely seen in children. Its features have not been well characterized in children. We sought to characterize the clinical features, etiologic associations, and treatment of PG in children younger than 18 years. METHODS: We performed a retrospective review of children younger than 18 years with PG at the Mayo Clinic from January 1976 to August 2013. RESULTS: Thirteen children with PG were identified (n = 8; 62% female)...
October 4, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27688446/efficacy-of-intense-pulsed-light-therapy-in-the-treatment-of-facial-acne-vulgaris-comparison-of-two-different-fluences
#11
Monika V Patidar, Ashish Ramchandra Deshmukh, Maruti Yadav Khedkar
BACKGROUND: Acne vulgaris is the most common disease of the skin affecting adolescents and young adults causing psychological distress. The combination of antibiotic resistance, adverse effects of topical and systemic anti acne medications and desire for high tech approaches have all led to new enthusiasm for light based acne treatment. Intense pulse light (IPL) therapy has three modes of action in acne vulgaris i.e., photochemical, photo thermal and photo immunological. AIMS: (1) to study efficacy of IPL therapy in facial acne vulgaris...
September 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27626705/evaluation-of-intraoperative-glove-change-in-prevention-of-postoperative-cerebrospinal-fluid-shunt-infections-and-the-predictors-of-shunt-infection
#12
Asma Bashir, Preben Sørensen
BACKGROUND: We have previously suggested that surgical gloves could be a possible means for transferring microorganisms from skin flora to shunt material during surgery. The objectives of this study were to examine (1) whether the rate of shunt infections was reduced after introducing intraoperative glove change before handling the shunt material; (2) clinical presentation of shunt infections, microbiological data, and treatment management; and (3) predictors of shunt infections. METHODS: A retrospective study of 432 shunt operations in 295 adults was undertaken over a 7-year period...
September 14, 2016: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/27622389/should-hidradenitis-suppurativa-acne-inversa-best-be-renamed-as-dissecting-terminal-hair-folliculitis
#13
WenChieh Chen, Gerd Plewig
Hidradenitis suppurativa/acne inversa is a diverse, enigmatic and distressful disease that has aroused growing interest in specialists from different disciplines. Both names describe its classical manifestations in the intertriginous regions and reflect the historical view of the disease definition, but cause confusions in the understanding of its pathogenesis and classification. In light of the advance in clinical, histopathological and pathophysiological findings, we propose the term "dissecting terminal hair folliculitis" (DTHF) to characterize its disease nature as folliculitis instead of acneiform disease or apocrine gland disorder...
September 13, 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27603410/is-propionibacterium-acnes-related-to-disc-degeneration-in-adults-a-systematic-review
#14
Pedro Berjano, Jorge H Villafañe, Dario Lo Re, Maryem Ismael, Marco Damilano, Lucia Bertozzi, Carlo L Romanò, Lorenzo Drago
INTRODUCTION: To systematically review the evidence linking Propionibacterium acnes with the development of symptomatic degenerative disc disease. EVIDENCE ACQUISITION: Data were obtained from MEDLINE from their inception to October 2015. Two authors independently conducted the searches, extracted data and completed methodological quality assessments. Articles were included if they investigated the presence of P. acnes in symptomatic degenerative disc disease through intra- operative cultural examination...
September 7, 2016: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/27596801/supplementation-with-lactobacillus-rhamnosus-sp1-normalises-skin-expression-of-genes-implicated-in-insulin-signalling-and-improves-adult-acne
#15
G Fabbrocini, M Bertona, Ó Picazo, H Pareja-Galeano, G Monfrecola, E Emanuele
Systemic supplementation with probiotics is increasingly being explored as a potential treatment strategy for skin disorders. Because both the gut-skin axis and dysregulation of insulin signalling have been implicated in the pathogenesis of adult acne, we designed the current study to evaluate the effect of supplementation with the probiotic strain Lactobacillus rhamnosus SP1 (LSP1) on skin expression of genes involved in insulin signalling and acne improvement in adult subjects. A pilot, randomised, double-blinded, placebo-controlled study was conducted with 20 adult subjects (14 females and 6 males; mean age: 33...
September 6, 2016: Beneficial Microbes
https://www.readbyqxmd.com/read/27581503/clinical-features-of-anaerobic-orthopaedic-infections
#16
Dan Lebowitz, Benjamin Kressmann, Shpresa Gjoni, Besa Zenelaj, Olivier Grosgurin, Christophe Marti, Matthieu Zingg, Ilker Uçkay
Some patient populations and types of orthopaedic surgery could be at particular risk for anaerobic infections. In this retrospective cohort study of operated adult patients with infections from 2004 to 2014, we assessed obligate anaerobes and considered first clinical infection episodes. Anaerobes, isolated from intra-operative samples, were identified in 2.4% of 2740 surgical procedures, of which half (33/65; 51%) were anaerobic monomicrobial infections. Propionibacterium acnes, a penicillin and vancomycin susceptible pathogen, was the predominantly isolated anaerobe...
August 31, 2016: Infectious Diseases
https://www.readbyqxmd.com/read/27569192/consumption-of-a-high-fat-diet-alters-the-seminal-fluid-and-gut-microbiomes-in-male-mice
#17
Angela B Javurek, William G Spollen, Sarah A Johnson, Nathan J Bivens, Karen H Bromert, Scott A Givan, Cheryl S Rosenfeld
Our prior work showed that a novel microbiome resides in the seminal vesicles of wild-type and oestrogen receptor α (Esr1) knock-out mice and is impacted by the presence of functional Esr1 genes. The seminal fluid microbiome (SFM) may influence the health and reproductive status of the male, along with that of his partner and offspring. A high-fat diet (HFD) alters metabolites and other factors within seminal fluid and might affect the SFM. Adult (~15 weeks old) male mice were placed for 4 weeks on a control or high-fat diet and seminal fluid and fecal samples were collected, bacterial DNA isolated and subjected to 16s rRNA sequencing...
August 29, 2016: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/27542588/adult-female-acne-and-associated-risk-factors-results-of-a-multicenter-case-control-study-in-italy
#18
Anna Di Landro, Simone Cazzaniga, Francesco Cusano, Angela Bonci, Cardinali Carla, Maria Letizia Musumeci, Annalisa Patrizi, Vincenzo Bettoli, Enrico Pezzarossa, Marzia Caproni, Anna Belloni Fortina, Elena Campione, Vito Ingordo, Luigi Naldi
BACKGROUND: The reasons for the appearance of acne in adulthood are largely unknown. OBJECTIVE: We explored the role of personal and environmental factors in adult female acne. METHODS: We conducted a multicenter case-control study in the outpatient departments of 12 Italian cities. Cases (n = 248) were consecutive women ≥25 years of age with newly diagnosed acne of any grade. Controls (n = 270) were females diagnosed with conditions other than acne...
December 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27537997/efficacy-and-safety-of-once-daily-dapsone-gel-7-5-for-treatment-of-adolescents-and-adults-with-acne-vulgaris-second-of-two-identically-designed-large-multicenter-randomized-vehicle-controlled-trials
#19
Lawrence F Eichenfield, Ted Lain, Ellen H Frankel, Terry M Jones, Joan-En Chang-Lin, David R Berk, Shiling Ruan, Alexandre Kaoukhov
BACKGROUND: Dapsone gel, 5% is administered twice daily for the treatment of acne vulgaris, and some patients may find adherence challenging.<BR /> OBJECTIVE: The study objective was to assess the efficacy and safety, compared with vehicle, of acne treatment with a recently FDA-approved, once-daily formulation of dapsone gel, 7.5%, with a 50% greater concentration of dapsone.<BR /> METHODS: This 12-week, randomized, double-blind, vehicle-controlled, multicenter clinical trial enrolled patients aged 12 years and older with 20-50 facial inflammatory lesions, 30-100 facial noninflammatory lesions, and an acne grade of 3 (moderate) on the Global Acne Assessment Score (GAAS)...
August 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/27536784/prevalence-of-propionibacterium-acnes-in-intervertebral-discs-of-patients-undergoing-lumbar-microdiscectomy-a-prospective-cross-sectional-study
#20
Manu N Capoor, Filip Ruzicka, Tana Machackova, Radim Jancalek, Martin Smrcka, Jonathan E Schmitz, Marketa Hermanova, Jiri Sana, Elleni Michu, John C Baird, Fahad S Ahmed, Karel Maca, Radim Lipina, Todd F Alamin, Michael F Coscia, Jerry L Stonemetz, Timothy Witham, Garth D Ehrlich, Ziya L Gokaslan, Konstantinos Mavrommatis, Christof Birkenmaier, Vincent A Fischetti, Ondrej Slaby
BACKGROUND: The relationship between intervertebral disc degeneration and chronic infection by Propionibacterium acnes is controversial with contradictory evidence available in the literature. Previous studies investigating these relationships were under-powered and fraught with methodical differences; moreover, they have not taken into consideration P. acnes' ability to form biofilms or attempted to quantitate the bioburden with regard to determining bacterial counts/genome equivalents as criteria to differentiate true infection from contamination...
2016: PloS One
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