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https://www.readbyqxmd.com/read/29674131/efficacy-of-cbd-enriched-medical-cannabis-for-treatment-of-refractory-epilepsy-in-children-and-adolescents-an-observational-longitudinal-study
#1
Moran Hausman-Kedem, Shay Menascu, Uri Kramer
The objective of this observational study was to evaluate the efficacy of medical cannabis for the treatment of refractory epilepsy. Fifty-seven patients (age 1-20 years) with epilepsy of various etiologies were treated with Cannabis oil extract (CBD/THC ratio of 20:1) for at least 3 months (Median follow up time-18 months). Forty-Six Patients were included in the efficacy analysis. Average CBD dose was11.4 mg/kg/d. Twenty-six patients (56%) had ≤50% reduction in mean monthly seizure frequency. There was no statistically significant difference in response rate among various epilepsy etiologies, and cannabis strain used...
April 16, 2018: Brain & Development
https://www.readbyqxmd.com/read/29576792/cannabis-essential-oil-a-preliminary-study-for-the-evaluation-of-the-brain-effects
#2
Nadia Gulluni, Tania Re, Idalba Loiacono, Giovanni Lanzo, Luigi Gori, Claudio Macchi, Francesco Epifani, Nicola Bragazzi, Fabio Firenzuoli
We examined the effects of essential oil from legal (THC <0.2% w/v) hemp variety on the nervous system in 5 healthy volunteers. GC/EIMS and GC/FID analysis of the EO showed that the main components were myrcene and β -caryophyllene. The experiment consisted of measuring autonomic nervous system (ANS) parameters; evaluations of the mood state; and electroencephalography (EEG) recording before treatment, during treatment, and after hemp inhalation periods as compared with control conditions. The results revealed decreased diastolic blood pressure, increased heart rate, and significant increased skin temperature...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29509231/the-challenge-of-clinical-application-of-fm2-cannabis-oil-produced-in-italy-for-the-treatment-of-neuropathic-pain
#3
S Pichini, R Pacifici, F P Busardò, A Tagliabracci, R Giorgetti
No abstract text is available yet for this article.
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29500810/nutritional-value-of-commercial-protein-rich-plant-products
#4
Pirjo Mattila, Sari Mäkinen, Merja Eurola, Taina Jalava, Juha-Matti Pihlava, Jarkko Hellström, Anne Pihlanto
The goal of this work was to analyze nutritional value of various minimally processed commercial products of plant protein sources such as faba bean (Vicia faba), lupin (Lupinus angustifolius), rapeseed press cake (Brassica rapa/napus subsp. Oleifera), flaxseed (Linum usitatissimum), oil hemp seed (Cannabis sativa), buckwheat (Fagopyrum esculentum), and quinoa (Chenopodium quinoa). Basic composition and various nutritional components like amino acids, sugars, minerals, and dietary fiber were determined. Nearly all the samples studied could be considered as good sources of essential amino acids, minerals and dietary fiber...
March 2, 2018: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/29429908/efficacy-of-artisanal-preparations-of-cannabidiol-for-the-treatment-of-epilepsy-practical-experiences-in-a-tertiary-medical-center
#5
Giulia S Porcari, Cary Fu, Emily D Doll, Emma G Carter, Robert P Carson
Medically refractory epilepsy continues to be a challenge worldwide, and despite an increasing number of medical therapies, approximately 1 in 3 patients continues to have seizures. Cannabidiol (CBD), one of many constituents of the Cannabis sativa or marijuana plant, has received renewed interest in the treatment of epilepsy. While highly purified CBD awaits Food and Drug Administration (FDA) approval, artisanal formulations of CBD are readily available and are seeing increased use in our patient population...
February 8, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29408718/detection-of-delta-9-tetrahydrocannabinol-thc-in-oral-fluid-blood-and-urine-following-oral-consumption-of-low-content-thc-hemp-oil
#6
Amie C Hayley, Luke A Downey, Glyn Hansen, Ashley Dowell, Dale Savins, Richard Buchta, Reinilda Catubig, Robert Houlden, Con K K Stough
Hemp-derivative (Cannabis sativa L.) food products containing trace levels of Δ-9-tetrahydrocannabinol (THC) are proposed for consumption in Australia and New Zealand; however, it is unclear whether use of these products will negatively affect existing drug screening protocols. This double-blind, within-subjects, cross-over trial assessed 35 adults (17 male; 18 female), aged 22-52 years [Mean=30.7, Standard Deviation (S.D)±7.6]. Low dose THC oil [5mL bearer sesame oil containing 10mg/kg THC (0.046mg THC per 5mL dose)]; high dose THC oil [5mL bearer sesame oil containing 20mg/kg THC (0...
March 2018: Forensic Science International
https://www.readbyqxmd.com/read/29362215/burns-from-illegal-cannabis-oil-manufacturing-a-case-series
#7
Sarthak Sinha, Kyle Ricord, Patricia Harasym, Jeff A Biernaskie, Duncan Nickerson, Vincent A Gabriel
BACKGROUND: The increasing consideration of cannabis legalization in Canada and the United States has motivated physicians to assess its prospective impact on the health care system. Health care providers in the burns community are concerned about injuries sustained as a result of the illegal manufacturing of cannabis oil because it involves highly flammable reagents. METHODS: We report a retrospective case series of patients with cannabis oil burns (identified by evidence of combustion during cannabis oil manufacturing) treated from April 2012 to March 2014 at the Foothills Medical Centre in Calgary, Alberta, Canada...
January 18, 2018: CMAJ Open
https://www.readbyqxmd.com/read/29317112/cannabinoid-disposition-after-human-intraperitoneal-use-an-insight-into-intraperitoneal-pharmacokinetic-properties-in-metastatic-cancer
#8
Catherine J Lucas, Peter Galettis, Shuzhen Song, Nadia Solowij, Stephanie E Reuter, Jennifer Schneider, Jennifer H Martin
BACKGROUND: Medicinal cannabis is prescribed under the provision of a controlled drug in the Australian Poisons Standard. However, multiple laws must be navigated in order for patients to obtain access and imported products can be expensive. Dose-response information for both efficacy and toxicity pertaining to medicinal cannabis is lacking. The pharmacokinetic properties of cannabis administered by traditional routes has been described but to date, there is no literature on the pharmacokinetic properties of an intraperitoneal cannabinoid emulsion...
January 6, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29317072/betacaryophyllene-a-phytocannabinoid-as-potential-therapeutic-modality-for-human-sepsis
#9
Angel Meza, Christian Lehmann
Sepsis is a clinical condition resulting from a dysregulated immune response to an infection that leads to organ dysfunction. Despite numerous efforts to optimize treatment, sepsis remains to be the main cause of death in most intensive care units. The endogenous cannabinoid system (ECS) plays an important role in inflammation. Cannabinoid receptor 2 (CB2R) activation is immunosuppressive, which might be beneficial during the hyper-inflammatory phase of sepsis. Beta-caryophyllene (BCP) is a non-psychoactive natural cannabinoid (phytocannabinoid) found in Cannabis sativa and in essential oils of spices and food plants, that acts as a selective agonist of CB2R...
January 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29247961/comprehensive-quality-evaluation-of-medical-cannabis-sativa-l-inflorescence-and-macerated-oils-based-on-hs-spme-coupled-to-gc-ms-and-lc-hrms-q-exactive-orbitrap%C3%A2-approach
#10
Lorenzo Calvi, Daniela Pentimalli, Sara Panseri, Luca Giupponi, Fabrizio Gelmini, Giangiacomo Beretta, Davide Vitali, Massimo Bruno, Emanuela Zilio, Radmila Pavlovic, Annamaria Giorgi
There are at least 554 identified compounds in C. sativa L., among them 113 phytocannabinoids and 120 terpenes. Phytocomplex composition differences between the pharmaceutical properties of different medical cannabis chemotype have been attributed to strict interactions, defined as 'entourage effect', between cannabinoids and terpenes as a result of synergic action. The chemical complexity of its bioactive constituents highlight the need for standardised and well-defined analytical approaches able to characterise the plant chemotype, the herbal drug quality as well as to monitor the quality of pharmaceutical cannabis extracts and preparations...
February 20, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29202510/extraction-method-and-analysis-of-cannabinoids-in-cannabis-olive-oil-preparations
#11
Antonella Casiraghi, Gabriella Roda, Eleonora Casagni, Cecilia Cristina, Umberto Maria Musazzi, Silvia Franzè, Paolo Rocco, Claudia Giuliani, Gelsomina Fico, Paola Minghetti, Veniero Gambaro
Recently, an increasing number of pharmacists had to supply medicinal products based on Cannabis sativa L. (Cannabaceae), prescribed by physicians to individual patients. Cannabis olive oil preparation is the first choice as a concentrated extract of cannabinoids, even though standardized operative conditions for obtaining it are still not available. In this work, the impact of temperature and extraction time on the concentration of active principles was studied to harmonize the different compounding methods, optimize the extraction process, and reduce the variability among preparations...
March 2018: Planta Medica
https://www.readbyqxmd.com/read/29189144/therapeutic-use-of-%C3%AE-9-thc-and-cannabidiol-evaluation-of-a-new-extraction-procedure-for-the-preparation-of-cannabis-based-olive-oil
#12
Luca Morini, Giorgio Porro, Maurizio Liso, Angelo Groppi
BACKGROUND: Since 2013 Cannabis-based preparations, containing the two main cannabinoids of interest, Δ9-tetrahydrocannabinol (THC), and cannabidiol (CBD), can be used for therapeutic purposes, such as palliative care, neurodegenerative disorder treatment and other therapies. The preparations may consist of a drug partition in sachets, capsules or through the extraction in certified olive oil. OBJECTIVE: The aims of the study were: a) to develop and validate a new liquid chromatographictandem mass spectrometric (LC-MS/MS) method for the identification and quantification of THC and CBD in olive oil; b) to evaluate the extraction efficiency and reproducibility of a new commercial extractor on the market...
2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29182999/analysis-of-cannabinoids-in-commercial-hemp-seed-oil-and-decarboxylation-kinetics-studies-of-cannabidiolic-acid-cbda
#13
Cinzia Citti, Barbara Pacchetti, Maria Angela Vandelli, Flavio Forni, Giuseppe Cannazza
Hemp seed oil from Cannabis sativa L. is a very rich natural source of important nutrients, not only polyunsaturated fatty acids and proteins, but also terpenes and cannabinoids, which contribute to the overall beneficial effects of the oil. Hence, it is important to have an analytical method for the determination of these components in commercial samples. At the same time, it is also important to assess the safety of the product in terms of amount of any psychoactive cannabinoid present therein. This work presents the development and validation of a highly sensitive, selective and rapid HPLC-UV method for the qualitative and quantitative determination of the main cannabinoids, namely cannabidiolic acid (CBDA), tetrahydrocannabinolic acid (THCA), cannabidiol (CBD), tetrahydrocannabinol (THC), cannabinol (CBN), cannabigerol (CBG) and cannabidivarin (CBDV), present in 13 commercial hemp seed oils...
February 5, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29057480/cannabinoids-concentration-variability-in-cannabis-olive-oil-galenic-preparations
#14
Chiara Carcieri, Cristina Tomasello, Marco Simiele, Amedeo De Nicolò, Valeria Avataneo, Luca Canzoneri, Jessica Cusato, Giovanni Di Perri, Antonio D'Avolio
OBJECTIVES: Knowledge of the exact concentration of active compounds in galenic preparations is crucial to be able to ensure their quality and to properly administer the prescribed dose. Currently, the need for titration of extracts is still debated. Considering this, together with the absence of a standard preparation method, the aim of this study was to evaluate cannabinoids concentrations variability in galenic olive oil extracts, to evaluate the interlot and interlaboratory variability in the extraction yield and in the preparation composition...
January 2018: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29044015/-argentina-enacts-first-law-on-medical-use-of-the-cannabis-plant-history-and-perspectives
#15
Eduardo L De Vito
In the last few years, great expectations have risen in the society concerning the eventual therapeutic usefulness of compounds derived from the cannabis plant. It is well known that these compounds are being used in treating certain health conditions, either through medical prescription or self-administration. Extreme opinions range from believing that it is a harmful and dangerous drug to sustaining that it is a panacea. However, the sheer existence of an endocannabinoid system in the brain compels us to study its dimensions and derivations thoroughly...
2017: Medicina
https://www.readbyqxmd.com/read/28983528/toxicant-formation-in-dabbing-the-terpene-story
#16
Jiries Meehan-Atrash, Wentai Luo, Robert M Strongin
Inhalable, noncombustible cannabis products are playing a central role in the expansion of the medical and recreational use of cannabis. In particular, the practice of "dabbing" with butane hash oil has emerged with great popularity in states that have legalized cannabis. Despite their growing popularity, the degradation product profiles of these new products have not been extensively investigated. The study herein focuses on the chemistry of myrcene and other common terpenes found in cannabis extracts. Methacrolein, benzene, and several other products of concern to human health were formed under the conditions that simulated real-world dabbing...
September 30, 2017: ACS Omega
https://www.readbyqxmd.com/read/28918484/drug-herb-interactions-in-the-elderly-patient-with-ibd-a-growing-concern
#17
REVIEW
Haider Rahman, Marina Kim, Galen Leung, Jesse A Green, Seymour Katz
Inflammatory bowel disease (IBD), which includes conditions such as Crohn's disease and ulcerative colitis, is becoming more prevalent with the elderly being the fastest growing group. Parallel to this, there is an increasing interest in the use of complementary and alternative medicine (CAM). Nearly half of patients with IBD have used CAM at one time. The elderly patients, however, are burdened by comorbid conditions, polypharmacy, and altered functional status. With increasing use of complementary and alternative medicine in our elderly patients with IBD, it is vital for the provider to provide counsel on drug-herb potential interactions...
December 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/28915313/a-metabolomic-approach-applied-to-a-liquid-chromatography-coupled-to-high-resolution-tandem-mass-spectrometry-method-hplc-esi-hrms-ms-towards-the-comprehensive-evaluation-of-the-chemical-composition-of-cannabis-medicinal-extracts
#18
Cinzia Citti, Umberto Maria Battisti, Daniela Braghiroli, Giuseppe Ciccarella, Martin Schmid, Maria Angela Vandelli, Giuseppe Cannazza
INTRODUCTION: Cannabis sativa L. is a powerful medicinal plant and its use has recently increased for the treatment of several pathologies. Nonetheless, side effects, like dizziness and hallucinations, and long-term effects concerning memory and cognition, can occur. Most alarming is the lack of a standardised procedure to extract medicinal cannabis. Indeed, each galenical preparation has an unknown chemical composition in terms of cannabinoids and other active principles that depends on the extraction procedure...
September 15, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28888560/unintentional-cannabis-ingestion-in-children-a-systematic-review
#19
REVIEW
John R Richards, Nishelle E Smith, Aimee K Moulin
OBJECTIVE: To analyze published reports of unintentional cannabis ingestions in children to determine presenting signs and symptoms, route of exposure, treatment, and outcome. STUDY DESIGN: PubMed, OpenGrey, and Google Scholar were systematically searched. Articles were selected, reviewed, and graded using Oxford Center for Evidence-Based Medicine guidelines. RESULTS: Of 3316 articles, 44 were included (3582 children age ≤12 years). We found no high quality (Oxford Center for Evidence-Based Medicine level I or II) studies and 10 level III studies documenting lethargy as the most common presenting sign and confirming increasing incidence of unintentional ingestion in states having decriminalized medical and recreational cannabis...
November 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28866904/a-selective-review-of-medical-cannabis-in-cancer-pain-management
#20
Alexia Blake, Bo Angela Wan, Leila Malek, Carlo DeAngelis, Patrick Diaz, Nicholas Lao, Edward Chow, Shannon O'Hearn
Insufficient management of cancer-associated chronic and neuropathic pain adversely affects patient quality of life. Patients who do not respond well to opioid analgesics, or have severe side effects from the use of traditional analgesics are in need of alternative therapeutic op-tions. Anecdotal evidence suggests that medical cannabis has potential to effectively manage pain in this patient population. This review presents a selection of representative clinical studies, from small pilot studies conducted in 1975, to double-blind placebo-controlled trials conducted in 2014 that evaluated the efficacy of cannabinoid-based therapies containing tetrahydrocannabinol (THC) and cannabidiol (CBD) for reducing cancer-associated pain...
December 2017: Annals of Palliative Medicine
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