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https://www.readbyqxmd.com/read/29202510/extraction-method-and-analysis-of-cannabinoids-in-cannabis-olive-oil-preparations
#1
Antonella Casiraghi, Gabriella Roda, Eleonora Casagni, Cecilia Cristina, Umberto Maria Musazzi, Silvia Franzè, Paolo Rocco, Claudia Giuliani, Gelsomina Fico, Paola Minghetti, Veniero Gambaro
Recently, an increasing number of pharmacists had to supply medicinal products based on Cannabis sativa L. (Cannabaceae), prescribed by physicians to individual patients. Cannabis olive oil preparation is the first choice as a concentrated extract of cannabinoids, even though standardized operative conditions for obtaining it are still not available. In this work, the impact of temperature and extraction time on the concentration of active principles was studied to harmonize the different compounding methods, optimize the extraction process, and reduce the variability among preparations...
December 4, 2017: Planta Medica
https://www.readbyqxmd.com/read/29189144/therapeutic-use-of-%C3%AE-9-thc-and-cannabidiol-evaluation-of-a-new-extraction-procedure-for-the-preparation-of-cannabis-based-olive-oil
#2
Luca Morini, Giorgio Porro, Maurizio Liso, Angelo Groppi
BACKGROUND: Since 2013 Cannabis-based preparations, containing the two main cannabinoids of interest, Δ9-tetrahydrocannabinol (THC), and cannabidiol (CBD), can be used for therapeutic purposes, such as palliative care, neurodegenerative disorder treatment and other therapies. The preparations may consist of a drug partition in sachets, capsules or through the extraction in certified olive oil. OBJECTIVE: the aims of the study were: a) to develop and validate a new liquid chromatographic-tandem mass spectrometric (LC-MS/MS) method for the identification and quantification of THC and CBD in olive oil; b) to evaluate the extraction efficiency and reproducibility of a new commercial extractor on the market...
November 29, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29182999/analysis-of-cannabinoids-in-commercial-hemp-seed-oil-and-decarboxylation-kinetics-studies-of-cannabidiolic-acid-cbda
#3
Cinzia Citti, Barbara Pacchetti, Maria Angela Vandelli, Flavio Forni, Giuseppe Cannazza
Hemp seed oil from Cannabis sativa L. is a very rich natural source of important nutrients, not only polyunsaturated fatty acids and proteins, but also terpenes and cannabinoids, which contribute to the overall beneficial effects of the oil. Hence, it is important to have an analytical method for the determination of these components in commercial samples. At the same time, it is also important to assess the safety of the product in terms of amount of any psychoactive cannabinoid present therein. This work presents the development and validation of a highly sensitive, selective and rapid HPLC-UV method for the qualitative and quantitative determination of the main cannabinoids, namely cannabidiolic acid (CBDA), tetrahydrocannabinolic acid (THCA), cannabidiol (CBD), tetrahydrocannabinol (THC), cannabinol (CBN), cannabigerol (CBG) and cannabidivarin (CBDV), present in 13 commercial hemp seed oils...
November 20, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29057480/cannabinoids-concentration-variability-in-cannabis-olive-oil-galenic-preparations
#4
Chiara Carcieri, Cristina Tomasello, Marco Simiele, Amedeo De Nicolò, Valeria Avataneo, Luca Canzoneri, Jessica Cusato, Giovanni Di Perri, Antonio D'Avolio
OBJECTIVES: Knowledge of the exact concentration of active compounds in galenic preparations is crucial to be able to ensure their quality and to properly administer the prescribed dose. Currently, the need for titration of extracts is still debated. Considering this, together with the absence of a standard preparation method, the aim of this study was to evaluate cannabinoids concentrations variability in galenic olive oil extracts, to evaluate the interlot and interlaboratory variability in the extraction yield and in the preparation composition...
October 23, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29044015/-argentina-enacts-first-law-on-medical-use-of-the-cannabis-plant-history-and-perspectives
#5
Eduardo L De Vito
In the last few years, great expectations have risen in the society concerning the eventual therapeutic usefulness of compounds derived from the cannabis plant. It is well known that these compounds are being used in treating certain health conditions, either through medical prescription or self-administration. Extreme opinions range from believing that it is a harmful and dangerous drug to sustaining that it is a panacea. However, the sheer existence of an endocannabinoid system in the brain compels us to study its dimensions and derivations thoroughly...
2017: Medicina
https://www.readbyqxmd.com/read/28983528/toxicant-formation-in-dabbing-the-terpene-story
#6
Jiries Meehan-Atrash, Wentai Luo, Robert M Strongin
Inhalable, noncombustible cannabis products are playing a central role in the expansion of the medical and recreational use of cannabis. In particular, the practice of "dabbing" with butane hash oil has emerged with great popularity in states that have legalized cannabis. Despite their growing popularity, the degradation product profiles of these new products have not been extensively investigated. The study herein focuses on the chemistry of myrcene and other common terpenes found in cannabis extracts. Methacrolein, benzene, and several other products of concern to human health were formed under the conditions that simulated real-world dabbing...
September 30, 2017: ACS Omega
https://www.readbyqxmd.com/read/28918484/drug-herb-interactions-in-the-elderly-patient-with-ibd-a-growing-concern
#7
REVIEW
Haider Rahman, Marina Kim, Galen Leung, Jesse A Green, Seymour Katz
Inflammatory bowel disease (IBD), which includes conditions such as Crohn's disease and ulcerative colitis, is becoming more prevalent with the elderly being the fastest growing group. Parallel to this, there is an increasing interest in the use of complementary and alternative medicine (CAM). Nearly half of patients with IBD have used CAM at one time. The elderly patients, however, are burdened by comorbid conditions, polypharmacy, and altered functional status. With increasing use of complementary and alternative medicine in our elderly patients with IBD, it is vital for the provider to provide counsel on drug-herb potential interactions...
December 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/28915313/a-metabolomic-approach-applied-to-a-liquid-chromatography-coupled-to-high-resolution-tandem-mass-spectrometry-method-hplc-esi-hrms-ms-towards-the-comprehensive-evaluation-of-the-chemical-composition-of-cannabis-medicinal-extracts
#8
Cinzia Citti, Umberto Maria Battisti, Daniela Braghiroli, Giuseppe Ciccarella, Martin Schmid, Maria Angela Vandelli, Giuseppe Cannazza
INTRODUCTION: Cannabis sativa L. is a powerful medicinal plant and its use has recently increased for the treatment of several pathologies. Nonetheless, side effects, like dizziness and hallucinations, and long-term effects concerning memory and cognition, can occur. Most alarming is the lack of a standardised procedure to extract medicinal cannabis. Indeed, each galenical preparation has an unknown chemical composition in terms of cannabinoids and other active principles that depends on the extraction procedure...
September 15, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28888560/unintentional-cannabis-ingestion-in-children-a-systematic-review
#9
John R Richards, Nishelle E Smith, Aimee K Moulin
OBJECTIVE: To analyze published reports of unintentional cannabis ingestions in children to determine presenting signs and symptoms, route of exposure, treatment, and outcome. STUDY DESIGN: PubMed, OpenGrey, and Google Scholar were systematically searched. Articles were selected, reviewed, and graded using Oxford Center for Evidence-Based Medicine guidelines. RESULTS: Of 3316 articles, 44 were included (3582 children age ≤12 years). We found no high quality (Oxford Center for Evidence-Based Medicine level I or II) studies and 10 level III studies documenting lethargy as the most common presenting sign and confirming increasing incidence of unintentional ingestion in states having decriminalized medical and recreational cannabis...
September 6, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28866904/a-selective-review-of-medical-cannabis-in-cancer-pain-management
#10
Alexia Blake, Bo Angela Wan, Leila Malek, Carlo DeAngelis, Patrick Diaz, Nicholas Lao, Edward Chow, Shannon O'Hearn
Insufficient management of cancer-associated chronic and neuropathic pain adversely affects patient quality of life. Patients who do not respond well to opioid analgesics, or have severe side effects from the use of traditional analgesics are in need of alternative therapeutic op-tions. Anecdotal evidence suggests that medical cannabis has potential to effectively manage pain in this patient population. This review presents a selection of representative clinical studies, from small pilot studies conducted in 1975, to double-blind placebo-controlled trials conducted in 2014 that evaluated the efficacy of cannabinoid-based therapies containing tetrahydrocannabinol (THC) and cannabidiol (CBD) for reducing cancer-associated pain...
August 23, 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/28818631/topical-medical-cannabis-a-new-treatment-for-wound-pain-three-cases-of-pyoderma-gangrenosum
#11
Vincent Maida, Jason Corban
Pain associated with integumentary wounds is highly prevalent, yet it remains an area of significant unmet need within health care. Currently, systemically administered opioids are the mainstay of treatment. However, recent publications are casting opioids in a negative light given their high side effect profile, inhibition of wound healing, and association with accidental overdose, incidents that are frequently fatal. Thus, novel analgesic strategies for wound-related pain need to be investigated. The ideal methods of pain relief for wound patients are modalities that are topical, lack systemic side effects, noninvasive, self-administered, and display rapid onset of analgesia...
August 14, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28750253/associations-between-butane-hash-oil-use-and-cannabis-related-problems
#12
Madeline H Meier
BACKGROUND: High-potency cannabis concentrates are increasingly popular in the United States, and there is concern that use of high-potency cannabis might increase risk for cannabis-related problems. However, little is known about the potential negative consequences of concentrate use. This study reports on associations between past-year use of a high-potency cannabis concentrate, known as butane hash oil (BHO), and cannabis-related problems. METHODS: A sample of 821 college students were recruited to complete a survey about their health and behavior...
July 14, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28624604/user-characteristics-and-effect-profile-of-butane-hash-oil-an-extremely-high-potency-cannabis-concentrate
#13
Gary C K Chan, Wayne Hall, Tom P Freeman, Jason Ferris, Adrian B Kelly, Adam Winstock
BACKGROUND: Recent reports suggest an increase in use of extremely potent cannabis concentrates such as Butane Hash Oil (BHO) in some developed countries. The aims of this study were to examine the characteristics of BHO users and the effect profiles of BHO. DESIGN: Anonymous online survey in over 20 countries in 2014 and 2015. Participants aged 18 years or older were recruited through onward promotion and online social networks. The overall sample size was 181,870...
June 8, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28610933/herbal-laxatives-and-antiemetics-in-pregnancy
#14
Reza Samavati, Eszter Ducza, Judit Hajagos-Tóth, Robert Gaspar
Constipation appears in the 2nd and 3rd trimester of pregnancy, while nausea is the strongest in the 1st trimester. This review summarizes the applicability of herbal laxatives and antiemetics in pregnancy. A human study has shown that flax oil as laxative is safe from 2nd trimester. Human data is not available about the rhubarb, but animal studies reveal that its emodin content induces fetal abnormalities. Fenugreek induces teratogenic malformation both in human and animals. Senna seed is proved as a safe laxative in pregnancy...
June 10, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28562230/biodegradation-of-phenol-and-benzene-by-endophytic-bacterial-strains-isolated-from-refinery-wastewater-fed-cannabis-sativa
#15
Aneela Iqbal, Muhammad Arshad, Imran Hashmi, Raghupathy Karthikeyan, Terry J Gentry, Arthur Paul Schwab
The presence of benzene and phenol in the environment can lead to serious health effects in humans and warrant development of efficient cleanup strategies. The aim of the present work was to assess the potential of indigenous endophytic bacterial strains to degrade benzene and phenol. Seven strains were successfully isolated from Cannabis sativa plants irrigated with oil refinery wastewater. Molecular characterization was performed by 16S rRNA gene sequencing. Phenol was biodegraded almost completely with Achromobacter sp...
June 13, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28455844/open-probe-fast-gc-ms-combining-ambient-sampling-ultra-fast-separation-and-in-vacuum-ionization-for-real-time-analysis
#16
Uri Keshet, Tal Alon, Alexander B Fialkov, Aviv Amirav
An Open Probe inlet was combined with a low thermal mass ultra-fast gas chromatograph (GC), in-vacuum electron eonization (EI) ion source and a mass spectrometer (MS) of GC-MS for obtaining real time analysis with separation. The Open Probe enables ambient sampling via sample vaporization in an oven that is open to room air and the ultra-fast GC provides ~30 s separation while if no separation is required it can act as a transfer line with 2-3 s sample transfer time. Sample analysis is as simple as touching the sample, pushing the sample holder into the open probe oven and getting the results in 30 s...
April 28, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28448475/formulation-characterization-and-properties-of-hemp-seed-oil-and-its-emulsions
#17
Veronika Mikulcová, Věra Kašpárková, Petr Humpolíček, Leona Buňková
The formulation, characterization, and anticipated antibacterial properties of hemp seed oil and its emulsions were investigated. The oil obtained from the seeds of Cannabis sativa L. in refined and unrefined form was characterized using iodine, saponification, acid values, and gas chromatography, and was employed for the preparation of stable oil-in-water emulsions. The emulsions were prepared using pairs of non-ionic surfactants (Tween, Span). The effects of the emulsification method (spontaneous emulsification vs...
April 27, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28431313/raman-spectroscopy-for-the-characterization-of-different-fractions-of-hemp-essential-oil-extracted-at-130%C3%A2-c-using-steam-distillation-method
#18
Muhammad Asif Hanif, Haq Nawaz, Saima Naz, Rubina Mukhtar, Nosheen Rashid, Ijaz Ahmad Bhatti, Muhammad Saleem
In this study, Raman spectroscopy along with Principal Component Analysis (PCA) is used for the characterization of pure essential oil (pure EO) isolated from the leaves of the Hemp (Cannabis sativa L.,) as well as its different fractions obtained by fractional distillation process. Raman spectra of pure Hemp essential oil and its different fractions show characteristic key bands of main volatile terpenes and terpenoids, which significantly differentiate them from each other. These bands provide information about the chemical composition of sample under investigation and hence can be used as Raman spectral markers for the qualitative monitoring of the pure EO and different fractions containing different active compounds...
July 5, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28397674/-self-medication-with-cannabidiol-oil-in-a-patient-with-primary-lateral-sclerosis
#19
Merete Karlsborg, Anette Kvindebjerg Christophersen, Caroline Pontoppidan, Jens Peter Kampmann
Many patients with neurological disorders have symptoms which are difficult to treat with conventional medication. In this case report we present a 40-year-old male patient with primary lateral sclerosis who used cannabidiol oil as therapy. We discuss the evidence of the effects of cannabidiol in the treatment of patients with neurological disease, and we raise the question: "Should patients who use illegal cannabis products as self-medication be diagnosed as drug abusers?"
February 13, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28355118/carbonyl-compounds-produced-by-vaporizing-cannabis-oil-thinning-agents
#20
William D Troutt, Matthew D DiDonato
OBJECTIVE: Cannabis use has increased in the United States, particularly the use of vaporized cannabis oil, which is often mixed with thinning agents for use in vaporizing devices. E-cigarette research shows that heated thinning agents produce potentially harmful carbonyls; however, similar studies have not been conducted (1) with agents that are commonly used in the cannabis industry and (2) at temperatures that are appropriate for cannabis oil vaporization. The goal of this study was to determine whether thinning agents used in the cannabis industry produce potentially harmful carbonyls when heated to a temperature that is appropriate for cannabis oil vaporization...
November 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
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