Robert J Lentz, Katherine Frederick-Dyer, Virginia B Planz, Tatsuki Koyama, Matthew C Aboudara, Briana Swanner, Lance Roller, See-Wei Low, Cristina Salmon, Sameer K Avasarala, Todd C Hoopman, Momen M Wahidi, Kamran Mahmood, George Z Cheng, James M Katsis, Jonathan S Kurman, Pierre-François D'Haese, Joyce Johnson, Eric L Grogan, Charla Walston, Lonny Yarmus, Gerard A Silvestri, Otis B Rickman, Najib M Rahman, Fabien Maldonado
BACKGROUND: Lung nodule incidence is increasing. Many nodules require biopsy to discriminate between benign and malignant etiologies. The gold-standard for minimally invasive biopsy, computed tomography-guided transthoracic needle biopsy (CT-TTNB), has never been directly compared to navigational bronchoscopy, a modality which has recently seen rapid technological innovation and is associated with improving diagnostic yield and lower complication rate. Current estimates of the diagnostic utility of both modalities are based largely on non-comparative data with significant risk for selection, referral, and publication biases...
November 23, 2023: medRxiv