Jeane do Nascimento Moraes, Aleff Ferreira Francisco, Leandro Moreira Dill, Rafaela Souza Diniz, Claudia Siqueira de Oliveira, Tainara Maiane Rodrigues da Silva, Cleópatra Alves da Silva Caldeira, Edailson de Alcântara Corrêa, Antônio Coutinho-Neto, Fernando Berton Zanchi, Marcos Roberto de Mattos Fontes, Andreimar Martins Soares, Leonardo de Azevedo Calderon
BACKGROUND: Cathepsin D (CatD) is a lysosomal proteolytic enzyme expressed in almost all tissues and organs. This protease is a multifunctional enzyme responsible for essential biological processes such as cell cycle regulation, differentiation, migration, tissue remodeling, neuronal growth, ovulation, and apoptosis. The overexpression and hypersecretion of CatD have been correlated with cancer aggressiveness and tumor progression, stimulating cancer cell proliferation, fibroblast growth, and angiogenesis...
2022: Journal of Venomous Animals and Toxins Including Tropical Diseases