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https://www.readbyqxmd.com/read/29912842/severe-mycoplasma-pneumoniae-infection-in-children-admitted-to-pediatric-intensive-care
#1
Katie M Moynihan, Andrew Barlow, Clare Nourse, Claire Heney, Sanmarié Schlebusch, Luregn J Schlapbach
Mycoplasma pneumoniae is a common cause of community-acquired pneumonia and may cause life-threatening disease in children. We identified 30 (0.3%) confirmed M. pneumoniae cases by clinical and laboratory criteria in 11,526 PICU admissions. Outcomes were comparable to patients admitted with other infections (n=3,005, p>0.1). Our findings indicate that empiric antimicrobial coverage for M. pneumoniae infection in PICU is rarely needed.
June 15, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29785832/lectin-microarray-combined-with-mass-spectrometry-identifies-haptoglobin-related-protein-hpr-as-a-potential-serologic-biomarker-for-separating-non-bacterial-pneumonia-from-bacterial-pneumonia-in-childhood
#2
Lin Yang, Zhou Yang, Lei Cheng, Juan Cheng, Li Cheng, Yangyang Sun, Wenting Li, Kai Song, Weichun Huang, Yong Yin, Shengce Tao, Qinghua Zhang
PURPOSE: Etiological diagnosis of pediatric patients with community-acquired pneumonia is difficult. For therapy, one of the major problems is the difficulty in separating bacterial pneumonia which would benefit from antibiotics from non-bacterial pneumonia. Therefore, we sought to identify potential biomarkers for distinguishing non-bacterial pneumonia from bacterial pneumonia. EXPERIMENTAL DESIGN: Lectin microarray containing 91 lectins was used to screen serums from pediatric patients with pneumonia...
May 22, 2018: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29759424/lung-ultrasound-findings-undetectable-by-chest-radiography-in-children-with-community-acquired-pneumonia
#3
Giulio Iorio, Maria Capasso, Salvatore Prisco, Giuseppe De Luca, Carlo Mancusi, Bruno Laganà, Maria Antonietta Piscopo, Vincenzo Comune
The purpose of our study was to evaluate any differences between lung ultrasonography and chest radiography (CR) images in children with a diagnosis of community-acquired pneumonia (CAP) and, if there are any, to analyze the reasons and possible clinical implications. We reviewed the medical records of patients admitted to the pediatric ward from January 2014 to December 2016 and selected only cases discharged with a diagnosis of CAP who had undergone performed lung ultrasound (LUS) and CR within 24 h of each other...
May 11, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29748840/clinical-patterns-epidemiology-and-risk-factors-of-community-acquired-urinary-tract-infection-caused-by-extended-spectrum-beta-lactamase-producers-a-prospective-hospital-case-control-study
#4
Basima A Almomani, Wail A Hayajneh, Abeer M Ayoub, Mera A Ababneh, Miral A Al Momani
PURPOSE: To assess incidence rate, risk factors and susceptibility patterns associated with extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli or Klebsiella pneumoniae in community-acquired urinary tract infections (CA-UTIs). METHODS: A prospective, case-control study was conducted at a tertiary teaching hospital from Jan 2015 to Dec 2016. The results of microbiology cultures were initially screened to include only patients with positive E. coli or K...
May 10, 2018: Infection
https://www.readbyqxmd.com/read/29748750/clinical-and-laboratory-features-of-children-with-community-acquired-pneumonia-are-associated-with-distinct-radiographic-presentations
#5
Oana G Falup-Pecurariu, Javier Diez-Domingo, Susanna Esposito, Adam Finn, Fernanda Rodrigues, Vana Spoulou, George A Syrogiannopoulos, Vytautas Usonis, David Greenberg
Chest radiographs from children with community-acquired pneumonia (CAP) were categorized into three distinct presentations and each presentation was correlated to clinical and laboratory findings. Children < 59 months with CAP presenting to pediatric emergency rooms during two years were enrolled prospectively in eight centers across Europe. Clinical and laboratory data were documented and radiographs obtained from patients. Of the 1107 enrolled patients, radiographs were characterized as 74.9% alveolar CAP, 8...
July 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29720921/disulfiram-like-reaction-involving-ceftriaxone-in-a-pediatric-patient
#6
Stephen M Small, Rachel S Bacher, Sheridan A Jost
Several medications have been shown to cause disulfiram-like reactions in patients concomitantly exposed to ethanol, including specific cephalosporin antibiotics that possess a methylthiotetrazole substituent. Within the cephalosporin class, there are few reports of disulfiram-like reactions with ceftriaxone. This case report is the first to involve a pediatric patient, and it describes a mild but likely disulfiram-like reaction manifesting as facial flushing in an 8-year-old male upon receiving a ceftriaxone infusion preceded by a dose of prednisolone elixir (5% ethanol by volume) for presumed community-acquired pneumonia thought to be complicated by an asthma exacerbation...
March 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/29696826/lung-ultrasound-compared-to-chest-x-ray-for-diagnosis-of-pediatric-pneumonia-a-meta-analysis
#7
REVIEW
Daniel S Balk, Christine Lee, Jesse Schafer, Jeremy Welwarth, John Hardin, Victor Novack, Shaked Yarza, Beatrice Hoffmann
OBJECTIVE: Although a clinical diagnosis, the standard initial imaging modality for patients with concern for pediatric community acquired pneumonia (pCAP) is a chest x-ray (CXR), which has a relatively high false negative rate, exposes patients to ionizing radiation, and may not be available in resource limited settings. The primary objective of this meta-analysis is to evaluate the accuracy of lung ultrasound (LUS) compared to CXR for the diagnosis of pCAP. METHODS: Data were collected via a systematic review of PubMed, EMBASE, and Web of Science with dates up to August 2017...
April 26, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29676360/detection-of-immunoglobulin-m-and-immunoglobulin-g-antibodies-to-mycoplasma-pneumoniae-in-children-with-community-acquired-lower-respiratory-tract-infections
#8
Surinder Kumar, Indu Bala Garg, Gulshan Rai Sethi, Sanchit Kumar, Sanjeev R Saigal
Context: Mycoplasma pneumoniae (M. pneumoniae) causes up to 40% of community-acquired pneumonia in children. It is impossible to identify M. pneumoniae infection on the basis of clinical signs, symptoms, and radiological features. Therefore, correct etiological diagnosis strongly depends on laboratory diagnosis. Aims: This study aims to investigate the role of M. pneumonia e in pediatric lower respiratory tract infections (LRTIs) employing enzyme-linked immunosorbent assays (ELISA) and particle agglutination (PA) test...
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29570940/lung-ultrasound-in-diagnosis-and-follow-up-of-community-acquired-pneumonia-in-infants-younger-than-1-year-old
#9
Ahmed Omran, Samah Eesai, Mostafa Ibrahim, Sonya El-Sharkawy
BACKGROUND: Pneumonia is still a leading cause of illness and death in infants worldwide. Lung ultrasound (LUS) is emerging as an extremely valuable non-ionizing radiation diagnostic tool in diagnosis and follow up of multiple paediatric pulmonary diseases. OBJECTIVE: To assess the applicability of LUS in diagnosis and follow up of community acquired pneumonia (CAP) in Egyptian infants younger than 1-year old. METHODS: LUS and chest X-ray (CXR) were performed in 50 infants presented with clinical symptoms and signs suggestive of CAP within the first 6 hours of admission in our inpatient department, then follow up LUS was performed 5 days after admission...
March 23, 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29540836/genetic-variations-in-the-fusion-protein-of-respiratory-syncytial-virus-isolated-from-children-hospitalized-with-community-acquired-pneumonia-in-china
#10
Xiangpeng Chen, Baoping Xu, Jiayun Guo, Changchong Li, Shuhua An, Yunlian Zhou, Aihuan Chen, Li Deng, Zhou Fu, Yun Zhu, Chunyan Liu, Lili Xu, Wei Wang, Kunling Shen, Zhengde Xie
To identify the variations in fusion (F) protein gene of RSV in China, a molecular epidemiological study was conducted. A total of 553 RSV positive specimens were collected from 2338 pediatric patients hospitalized with community-acquired pneumonia during a multi-center study conducted during 2014-2016. A total of 252 samples (183 RSV A, 69 RSV B) were selected for F gene sequencing, and analyzed together with 142 F gene sequences downloaded from GenBank. The result showed that all the Chinese RSV A and RSV B strains could be divided respectively into three branches...
March 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29531001/reliability-of-pro-adrenomedullin-and-interleukin-1%C3%AE-in-predicting-severity-of-community-acquired-pneumonia-in-pediatric-patients
#11
Muhammet Furkan Korkmaz, Ahmet Güzel, Mehmet Açıkgöz, Ali Okuyucu, Hasan Alaçam
OBJECTIVES: Community-acquired pneumonia (CAP) in children is one of the most important causes of mortality and morbidity in developing countries. Therefore, it is very important for clinicians to detect the presence and severity of pneumonia. Proadrenomedullin (Pro-ADM) and Interleukin-1β (IL-1β) are thought to have potential for CAP evaluation in children. We sought to investigate the value of Pro-ADM and IL-1β levels for severity assessment and outcome prediction in children with CAP...
January 2018: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29528913/community-acquired-pneumonia-with-pleural-effusion-in-children-and-municipal-human-development-index-m-hdi-in-rio-de-janeiro-brazil
#12
Marcelo Land, Paula Maia, Maria de Fátima March, Alvaro Ferreira, Clemax Sant Anna
This study evaluated admissions with severe community-acquired pneumonia (CAP) with pleural effusion (PE) in a pediatric university hospital and the impact of the increased average municipal human development index (M-HDI) in the local incidence of the disease in the last decade. METHODS: This is a retrospective longitudinal study of patients (0 to 13 years old) with CAP. The M-DHI of the place of residence of patients was obtained. We calculate the crude odds ratios (OR) of variables related to risk of developing PE...
March 9, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29528891/complicated-pneumonia-current-concepts-and-state-of-the-art
#13
Michael C Tracy, Roshni Mathew
PURPOSE OF REVIEW: This review aims to provide clinicians engaged in the care of infants and children an update on the current understanding of the epidemiology, etiology, diagnostic evaluation, and clinical management of complicated pneumonia. The review provides timely information surrounding areas of consensus and ongoing research. RECENT FINDINGS: The epidemiology and etiologies of complicated pneumonia continue to evolve over the past several decades in context of the introduction of new vaccines...
June 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29523959/the-light-at-the-end-of-the-tunnel-an-unusual-case-of-acute-kidney-injury-in-a-pediatric-patient-answers
#14
Miriam Steinberg, Joseph P Gaut, Stanley Paul Hmiel, Aadil Kakajiwala
Monoclonal gammopathies are a rare diagnosis in pediatric patients. A 19-year-old female patient with past medical history of hypogammaglobulinemia and natural killer cell deficiency and stage III follicular lymphoma, in remission, presented with a right-sided pneumonia, noted to have acute kidney injury and proteinuria. Complement C3 and C4 levels were normal. Anti-double-stranded DNA antibodies, antinuclear antibodies, anti-extractable nuclear antigen antibodies, and antineutrophil cytoplasmic antibodies were negative...
March 9, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29513362/a-multisite-intervention-for-pediatric-community-acquired-pneumonia-in-community-settings
#15
Corrie E McDaniel, Wren Haaland, Joshua Parlaman, Chuan Zhou, Arti D Desai
OBJECTIVES: The majority of children with community-acquired pneumonia (CAP) are primarily evaluated in community hospital emergency departments (EDs); however, studies on the management of pediatric CAP have largely targeted care provided in freestanding children's hospital EDs or inpatient settings. The objectives of this study were to examine whether implementation of a CAP pathway within three community hospital EDs and inpatient units improved process measures related to appropriate laboratory testing and antibiotic prescribing and to compare performance on these measures between the community hospitals and a freestanding children's hospital...
March 7, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29489898/effects-of-clinical-pathway-implementation-on-antibiotic-prescriptions-for-pediatric-community-acquired-pneumonia
#16
Daniele Donà, Silvia Zingarella, Andrea Gastaldi, Rebecca Lundin, Giorgio Perilongo, Anna Chiara Frigo, Rana F Hamdy, Theoklis Zaoutis, Liviana Da Dalt, Carlo Giaquinto
BACKGROUND: Italian pediatric antimicrobial prescription rates are among the highest in Europe. As a first step in an Antimicrobial Stewardship Program, we implemented a Clinical Pathway (CP) for Community Acquired Pneumonia with the aim of decreasing overall prescription of antibiotics, especially broad-spectrum. MATERIALS AND METHODS: The CP was implemented on 10/01/2015. We collected antibiotic prescribing and outcomes data from children aged 3 months-15 years diagnosed with CAP from 10/15/2014 to 04/15/2015 (pre-intervention period) and from 10/15/2015 to 04/15/2016 (post-intervention period)...
2018: PloS One
https://www.readbyqxmd.com/read/29440952/antibiotic-treatment-in-childhood-community-acquired-pneumonia-clinical-practice-versus-guidelines-results-from-two-university-hospitals
#17
Sorin Claudiu Man, Valentina Sas, Cristina Schnell, Camelia Florea, Adelina Ţuţu, Ariana Szilágyi, Sergiu Belenes, Amalia Hebriştean, Anca Bonaţ, Claudia Cladovan, Cornel Aldea
Background and aims: Community-acquired pneumonia (CAP) is a both common and serious childhood infection. Antibiotic treatment guidelines help to reduce inadequate antibiotics prescriptions. Methods: We conducted a retrospective study at the Clinical Emergency Hospital for Children, 3rd Pediatric Clinic, Cluj-Napoca and Dr. Gavril Curteanu Clinical City Hospital, in Oradea. All patients discharged with a diagnosis of CAP between December 1, 2014 and February 28, 2015, were included in the study...
2018: Clujul Medical (1957)
https://www.readbyqxmd.com/read/29438527/effects-of-hospital-practice-patterns-for-antibiotic-administration-for-pneumonia-on-hospital-lengths-of-stay-and-costs
#18
Eric W Christensen, Alicen Burns Spaulding, William F Pomputius, Steven P Grapentine
Background: Hospital practice patterns vary for switching from intravenous to oral antibiotics for community-acquired pneumonia in pediatric patients, but it is unknown how these practice patterns affect hospital lengths of stay and costs. Methods: We conducted a retrospective study of 78673 pediatric patients (aged 3 months to 17 years) hospitalized for community-acquired pneumonia. Analyses were performed with data from the Pediatric Health Information System between 2007 and 2016, including discharge data from 48 freestanding children's hospitals...
February 8, 2018: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29438130/blood-culture-and-pleural-fluid-culture-yields-in-pediatric-empyema-patients-a-retrospective-review-1996-2016
#19
Christina T Stankey, Alicen B Spaulding, Angela Doucette, Karen E S Hamre, William Wheeler, William F Pomputius, Stephen Kurachek
Empyema is a complication of community-acquired pneumonia. We conducted a retrospective analysis of empyema patients discharged from 1996-2016, examining culture results according to timing of antibiotic administration. Blood culture decreased from 45% to 4% after antibiotics, and pleural fluid culture yield decreased from 67% to 30%. More than half of methicillin-resistant Staphylococcus aureus cases occurred from 2011-2016.
February 12, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29346512/validation-of-the-pids-idsa-severity-criteria-in-children-with-community-acquired-pneumonia
#20
Todd A Florin, Cole Brokamp, Rachel Mantyla, Bradley DePaoli, Richard Ruddy, Samir S Shah, Lilliam Ambroggio
Background: The Pediatric Infectious Diseases Society (PIDS)/Infectious Diseases Society of America (IDSA) guideline for community-acquired pneumonia (CAP) recommends intensive care unit (ICU) admission or continuous monitoring for children meeting severity criteria. Our objective was to validate these criteria. Methods: This was a retrospective cohort study of children age 3 months-18 years diagnosed with CAP in a pediatric Emergency Department (ED) from 9/2014-8/2015...
January 13, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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