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https://www.readbyqxmd.com/read/28039666/use-of-ceftaroline-fosamil-in-children-review-of-current-knowledge-and-its-application
#1
REVIEW
Juwon Yim, Leah M Molloy, Jason G Newland
Ceftaroline is a novel cephalosporin recently approved in children for treatment of acute bacterial skin and soft tissue infections and community-acquired bacterial pneumonia (CABP) caused by methicillin-resistant Staphylococcus aureus, Streptococcus pneumoniae and other susceptible bacteria. With a favorable tolerability profile and efficacy proven in pediatric patients and excellent in vitro activity against resistant Gram-positive and Gram-negative bacteria, ceftaroline may serve as a therapeutic option for polymicrobial infections, CABP caused by penicillin- and ceftriaxone-resistant S...
December 30, 2016: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/27977560/ceftaroline-activity-tested-against-bacterial-isolates-causing-community-acquired-respiratory-tract-infections-and-skin-and-skin-structure-infections-in-pediatric-patients-from-united-states-hospitals-2012-2014
#2
Michael A Pfaller, Rodrigo E Mendes, Mariana Castanheira, Robert K Flamm, Ronald N Jones, Helio S Sader
Ceftaroline fosamil has recently received United States Food and Drug Administration (US-FDA) approval for treatment of acute bacterial skin/skin structure infections (SSSI), including those caused by methicillin-resistant Staphylococcus aureus (MRSA) and community-acquired bacterial pneumonia for pediatric patients ≥2 months old. We evaluated the potency and spectrum of ceftaroline and comparators when tested against community-acquired respiratory tract (CARTI) and SSSI pathogens from pediatric patients...
December 12, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27956727/assessment-of-cytokine-and-chemokine-signatures-as-potential-biomarkers-of-childhood-community-acquired-pneumonia-severity-a-nested-cohort-study-in-india
#3
Shanie Saghafian-Hedengren, Joseph L Mathew, Eva Hagel, Sunit Singhi, Pallab Ray, Sofia Ygberg, Anna Nilsson
BACKGROUND: Pediatric community-acquired pneumonia (CAP) is a leading cause of childhood mortality in developing countries. In resource-poor settings, pneumonia diagnosis is commonly made clinically, based on World Health Organization guidelines, where breathing difficulty or cough and age-adjusted tachypnea suffice to establish diagnosis. Also, the severity of CAP is generally based on clinical features and existing biomarkers do not reliably correlate to either clinical severity or outcome...
January 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27917707/management-of-pneumonia-in-the-pediatric-critical-care-unit-an-area-for-antimicrobial-stewardship
#4
Aimee M Dassner, David P Nicolau, Jennifer E Girotto
Pediatric pneumonia is one of the most common causes of childhood infection requiring hospitalization and is a substantial driver of antimicrobial use among hospitalized children. About 12-20% of pediatric patients hospitalized with community-acquired pneumonia (CAP) require critical care. Additionally, nosocomial pneumonias (i.e. hospital-acquired and ventilator-associated pneumonias) are responsible for 15-53% of hospital-associated infections and are the most common indication for empiric antibiotics in the pediatric intensive care unit...
December 4, 2016: Current Pediatric Reviews
https://www.readbyqxmd.com/read/27912925/cardiac-arrest-in-pediatric-patients-receiving-azithromycin
#5
Santiago O Valdés, Jeffrey J Kim, Mary C Niu, Caridad M de la Uz, Christina Y Miyake, Brady S Moffett
OBJECTIVE: To compare outcomes of pediatric patients treated with azithromycin compared with penicillin or cephalosporin. We hypothesized that azithromycin use would not be associated with increased cardiac mortality in the pediatric population. STUDY DESIGN: Retrospective cohort study from the Pediatric Health Information System database between 2008 and 2012. Patients <19 years of age with a principal diagnosis of community-acquired pneumonia who received an antibiotic were included...
November 29, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27811579/a-comprehensive-approach-to-pediatric-pneumonia-relationship-between-standardization-antimicrobial-stewardship-clinical-testing-and-cost
#6
Lori Rutman, Davene R Wright, James OʼCallaghan, Suzanne Spencer, K Casey Lion, Matthew P Kronman, Chuan Zhou, Rita Mangione-Smith
OBJECTIVE: In September 2012, our institution implemented an emergency department (ED) and inpatient pathway for community-acquired pneumonia (CAP) based on national guideline recommendations. The objective of this study was to determine the relationship between standardizing ED and inpatient care for CAP and antimicrobial stewardship, clinical testing, and cost. METHODS: We used descriptive statistics, statistical process control, and interrupted time series analysis to analyze measures 12 months before and after implementation...
November 1, 2016: Journal for Healthcare Quality: Official Publication of the National Association for Healthcare Quality
https://www.readbyqxmd.com/read/27803071/characteristics-of-children-hospitalized-with-aspiration-pneumonia
#7
Alexander W Hirsch, Michael C Monuteaux, Genna Fruchtman, Richard G Bachur, Mark I Neuman
OBJECTIVES: Unlike community-acquired pneumonia (CAP), there is a paucity of data characterizing the patient demographics and hospitalization characteristics of children with aspiration pneumonia. We used a large national database of US children's hospitals to assess the patient and hospitalization characteristics associated with aspiration pneumonia and compared these characteristics to patients with CAP. METHODS: We identified children hospitalized with a diagnosis of aspiration pneumonia or CAP at 47 hospitals included in the Pediatric Health Information System between 2009 and 2014...
November 2016: Hospital Pediatrics
https://www.readbyqxmd.com/read/27766169/microbial-etiology-of-community-acquired-pneumonia-among-infants-and-children-admitted-to-the-pediatric-hospital-ain-shams-university
#8
Magda Yehia El Seify, Eman Mahmoud Fouda, Hanan Mohamed Ibrahim, Maha Muhammad Fathy, Asmaa Al Husseiny Ahmed, Walaa Shawky Khater, Noha Nagi Mohammed Salah El Deen, Heba Galal Mohamed Abouzeid, Nancy Riyad Ahmed Hegazy, Heba Salah Sayed Elbanna
BACKGROUND: While recognizing the etiology of community-acquired pneumonia is necessary for formulating local antimicrobial guidelines, limited data is published about this etiology in Egyptian pediatric patients. OBJECTIVES: To determine the frequency of bacterial and viral pathogens causing community-acquired pneumonia (CAP) among immunocompetent Egyptian infants and preschool children. METHODS: Ninety infants and preschool-age children admitted to our hospital with CAP were prospectively included in the study...
September 29, 2016: European Journal of Microbiology & Immunology
https://www.readbyqxmd.com/read/27688362/predicting-severe-pneumonia-outcomes-in-children
#9
Derek J Williams, Yuwei Zhu, Carlos G Grijalva, Wesley H Self, Frank E Harrell, Carrie Reed, Chris Stockmann, Sandra R Arnold, Krow K Ampofo, Evan J Anderson, Anna M Bramley, Richard G Wunderink, Jonathan A McCullers, Andrew T Pavia, Seema Jain, Kathryn M Edwards
BACKGROUND: Substantial morbidity and excessive care variation are seen with pediatric pneumonia. Accurate risk-stratification tools to guide clinical decision-making are needed. METHODS: We developed risk models to predict severe pneumonia outcomes in children (<18 years) by using data from the Etiology of Pneumonia in the Community Study, a prospective study of community-acquired pneumonia hospitalizations conducted in 3 US cities from January 2010 to June 2012...
October 2016: Pediatrics
https://www.readbyqxmd.com/read/27627439/a-gexp-based-assay-for-simultaneous-detection-of-multiple-viruses-in-hospitalized-children-with-community-acquired-pneumonia
#10
Le Wang, Mengchuan Zhao, Zhongren Shi, Zhishan Feng, Weiwei Guo, Shuo Yang, Lanping Liu, Guixia Li
The GeXP-based assay has recently been developed for simultaneous detection of multiple pathogens. So far, the application of the GeXP assay to test larger clinical samples has hardly been reported. Community-acquired pneumonia (CAP) is the leading cause of death in children worldwide and a substantial proportion of childhood CAP is caused by viruses. Rapid and accurate diagnosis of virus infection is important for the clinical management of CAP. In this study, we explored the GeXP assay for simultaneous detection of 20 types/subtypes of viruses in hospitalized children with CAP...
2016: PloS One
https://www.readbyqxmd.com/read/27510635/population-pk-modeling-and-target-attainment-simulations-to-support-dosing-of-ceftaroline-fosamil-in-pediatric-patients-with-absssi-and-cabp
#11
Todd A Riccobene, Tatiana Khariton, William Knebel, Shampa Das, James Li, Alena Jandourek, Timothy J Carrothers, John S Bradley
Ceftaroline, the active form of the pro-drug ceftaroline fosamil, is approved for use in adults with community-acquired bacterial pneumonia (CABP) or acute bacterial skin and skin structure infections (ABSSSI) in the United States and similar indications in Europe. Pharmacokinetic (PK) data from five pediatric (birth to <18 years) studies of ceftaroline fosamil were combined with PK data from adults to update a population PK model for ceftaroline and ceftaroline fosamil. This model, based on a dataset including 305 children, was used to conduct simulations to estimate ceftaroline exposures and percentage of time that free drug concentrations were above the minimum inhibitory concentration (%fT>MIC) for pediatric dose regimens...
August 11, 2016: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27439403/measurement-of-lipocalin-2-and-syndecan-4-levels-to-differentiate-bacterial-from-viral-infection-in-children-with-community-acquired-pneumonia
#12
Susanna Esposito, Sonia Bianchini, Monia Gambino, Barbara Madini, Giada Di Pietro, Giulia Umbrello, Maria Lory Presicce, Luca Ruggiero, Leonardo Terranova, Nicola Principi
BACKGROUND: In this study, we evaluated the lipocalin-2 (LIP2) and syndecan-4 (SYN4) levels in children who were hospitalized for radiologically confirmed CAP in order to differentiate bacterial from viral infection. The results regarding the LIP2 and SYN4 diagnostic outcomes were compared with the white blood cell (WBC) count and C reactive protein (CRP) levels. METHODS: A total of 110 children <14 years old who were hospitalized for radiologically confirmed CAP were enrolled...
2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27412542/-change-in-serum-intestinal-fatty-acid-binding-protein-and-its-significance-in-children-with-pneumonia-and-gastrointestinal-injury
#13
Xiao-Lei Fan, Hai-Ying Li, Xiao-Xin Chen, Lei Xie, Huai-Li Wang
OBJECTIVE: To study the change in serum intestinal fatty acid binding protein (IFABP) in children with pneumonia and its correlation with gastrointestinal injury. METHODS: A total of 82 children with community-acquired pneumonia who were treated from January to October, 2015 were enrolled, among whom 34 had mild pneumonia and 48 had severe pneumonia. According to pediatric critical illness score (PCIS), the children with severe pneumonia were further divided into non-critical group (25 patients) and critical group (23 patients)...
July 2016: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/27399106/high-prevalence-of-hospital-acquired-infections-caused-by-gram-negative-carbapenem-resistant-strains-in-vietnamese-pediatric-icus-a-multi-centre-point-prevalence-survey
#14
Ngai Kien Le, Wertheim Hf, Phu Dinh Vu, Dung Thi Khanh Khu, Hai Thanh Le, Bich Thi Ngoc Hoang, Vu Thanh Vo, Yen Minh Lam, Dung Tien Viet Vu, Thu Hoai Nguyen, Tung Quang Thai, Lennart E Nilsson, Ulf Rydell, Kinh Van Nguyen, Behzad Nadjm, Louise Clarkson, Håkan Hanberger, Mattias Larsson
There is scarce information regarding hospital-acquired infections (HAIs) among children in resource-constrained settings. This study aims to measure prevalence of HAIs in Vietnamese pediatric hospitals.Monthly point prevalence surveys (PPSs) in 6 pediatric intensive care units (ICUs) in 3 referral hospitals during 1 year.A total of 1363 cases (1143 children) were surveyed, 59.9% male, average age 11 months. Admission sources were: other hospital 49.3%, current hospital 36.5%, and community 15.3%. Reasons for admission were: infectious disease (66%), noninfectious (20...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27392317/complicated-community-acquired-pneumonia-in-childhood-different-types-clinical-course-and-outcome
#15
Ira Erlichman, Oded Breuer, David Shoseyov, Malena Cohen-Cymberknoh, Benjamin Koplewitz, Diana Averbuch, Matti Erlichman, Elie Picard, Eitan Kerem
: The incidence of pediatric community acquired complicated pneumonia (PCACP) is increasing. Questions addressed: Are different types of PCACP one disease? How do different treatment protocols affect the outcome? METHODS: Retrospective analysis of medical records of PCACP hospitalizations in the three major hospitals in Jerusalem in the years 2001-2010 for demographics, clinical presentation, management, and outcome. RESULTS: Of the 144 children (51% aged 1-4 years), 91% of Jewish origin; 40% had para-pneumonic effusion (PPE), 40% empyema (EMP), and 20% necrotizing pneumonia (NP)...
July 8, 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27383534/pneumonia-and-influenza-hospitalizations-among-children-under-5%C3%A2-years-of-age-in-suzhou-china-2005-2011
#16
Xiyan Zhang, Jun Zhang, Liling Chen, Luzhao Feng, Hongjie Yu, Genming Zhao, Tao Zhang
BACKGROUND: The disease burden of influenza among children in China has not been well described. OBJECTIVE: To estimate the influenza-associated excess hospitalization rate and compare the hospitalization length and costs between pneumonia and influenza (P&I) and other community-acquired diseases (CAD) in Suzhou, China. METHODS: We retrospectively collected hospital discharge data on pediatric patients' discharge diagnosis, hospital costs, and length of hospital stay in Suzhou...
January 2017: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/27383523/mechanism-of-hyponatremia-in-community-acquired-pneumonia-does-b-type-natriuretic-peptide-play-a-causative-role
#17
Moran Hausman-Kedem, Shimon Reif, Dana Danino, Rona Limor, Zachary M Grinspan, Anat Yerushalmi-Feler, Amir Ben-Tov, Amir Birger
OBJECTIVE: Hyponatremia is a well-known sequela of community-acquired pneumonia (CAP). B-type natriuretic peptide (BNP) has a natriuretic effect and was found to be elevated in patients with CAP. We investigated whether BNP has a role in the pathophysiology of hyponatremia in pediatric CAP. METHODS: Serum and urine electrolytes and osmolality, as well as NT-pro-BNP (N-BNP), were obtained in 49 hospitalized pediatric patients with CAP (29 with hyponatremia, 20 with normal sodium levels...
May 31, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27366076/prescription-of-antibiotics-in-community-acquired-pneumonia-in-children-are-we-following-the-recommendations
#18
Eduardo Jorge da Fonseca Lima, Débora Ellen Pessoa Lima, George Henrique Cordeiro Serra, Maria Anaide Zacche S Abreu E Lima, Maria Júlia Gonçalves de Mello
OBJECTIVE: To assess the adequacy of antibiotic prescription in children hospitalized for pneumonia in a reference pediatric hospital in Brazil. METHODS: This was a cross-sectional study involving children aged between 1 month and 5 years who were hospitalized between October 2010 and September 2013. The classification of community-acquired pneumonia (CAP) was based on the clinical and radiological criteria of the World Health Organization (WHO). The analysis of antibiotic adequacy was performed according to the main guidelines on CAP treatment, which include the WHO guidelines, Brazilian Society of Pediatrics guidelines, and international guidelines (Pediatrics Infectious Diseases Society, the Infectious Disease Society of America, British Thoracic Society, and Consenso de la Sociedad latinoamericana de Infectología)...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27242718/epidemiology-of-mycoplasma-pneumoniae-infections-in-japan-and-therapeutic-strategies-for-macrolide-resistant-m-pneumoniae
#19
REVIEW
Tsutomu Yamazaki, Tsuyoshi Kenri
Pneumonia caused by Mycoplasma pneumoniae (M. pneumoniae pneumonia) is a major cause of community-acquired pneumonia worldwide. The surveillance of M. pneumoniae pneumonia is important for etiological and epidemiological studies of acute respiratory infections. In Japan, nation-wide surveillance of M. pneumoniae pneumonia has been conducted as a part of the National Epidemiological Surveillance of Infectious Diseases (NESID) program. This surveillance started in 1981, and significant increases in the numbers of M...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27107685/factors-associated-with-severity-in-invasive-community-acquired-staphylococcus-aureus-infections-in-children-a-prospective-european-multicentre-study
#20
M Gijón, M Bellusci, B Petraitiene, A Noguera-Julian, V Zilinskaite, P Sanchez Moreno, J Saavedra-Lozano, D Glikman, M Daskalaki, P Kaiser-Labusch, O Falup-Pecurariu, C Montagnani, L Prieto, A Gené, G Trumpulyte, I Kulecnikova, J A Lepe, E Cercenado, R Kudinsky, A Makri, H I Huppertz, L Bleotu, P Cocchi, P García-Hierro, A Vitkauskiene, C Fortuny, V Zukovskaja, O Neth, M Santos, A Rokney, M Petra, R Lixandru, L Galli, S Guillén, F Chaves, P Rojo Conejo
Staphylococcus aureus is the main pathogen responsible for bone and joint infections worldwide and is also capable of causing pneumonia and other invasive severe diseases. Panton-Valentine leukocidin (PVL) and methicillin-resistant S. aureus (MRSA) have been studied as factors related with severity in these infections. The aims of this study were to describe invasive community-acquired S. aureus (CA-SA) infections and to analyse factors related to severity of disease. Paediatric patients (aged 0-16 years) who had a CA-SA invasive infection were prospectively recruited from 13 centres in 7 European countries...
July 2016: Clinical Microbiology and Infection
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