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https://www.readbyqxmd.com/read/29474906/a-hematogenous-route-for-medulloblastoma-leptomeningeal-metastases
#1
Livia Garzia, Noriyuki Kijima, A Sorana Morrissy, Pasqualino De Antonellis, Ana Guerreiro-Stucklin, Borja L Holgado, Xiaochong Wu, Xin Wang, Michael Parsons, Kory Zayne, Alex Manno, Claudia Kuzan-Fischer, Carolina Nor, Laura K Donovan, Jessica Liu, Lei Qin, Alexandra Garancher, Kun-Wei Liu, Sheila Mansouri, Betty Luu, Yuan Yao Thompson, Vijay Ramaswamy, John Peacock, Hamza Farooq, Patryk Skowron, David J H Shih, Angela Li, Sherine Ensan, Clinton S Robbins, Myron Cybulsky, Siddhartha Mitra, Yussanne Ma, Richard Moore, Andy Mungall, Yoon-Jae Cho, William A Weiss, Jennifer A Chan, Cynthia E Hawkins, Maura Massimino, Nada Jabado, Michal Zapotocky, David Sumerauer, Eric Bouffet, Peter Dirks, Uri Tabori, Poul H B Sorensen, Priscilla K Brastianos, Kenneth Aldape, Steven J M Jones, Marco A Marra, James R Woodgett, Robert J Wechsler-Reya, Daniel W Fults, Michael D Taylor
While the preponderance of morbidity and mortality in medulloblastoma patients are due to metastatic disease, most research focuses on the primary tumor due to a dearth of metastatic tissue samples and model systems. Medulloblastoma metastases are found almost exclusively on the leptomeningeal surface of the brain and spinal cord; dissemination is therefore thought to occur through shedding of primary tumor cells into the cerebrospinal fluid followed by distal re-implantation on the leptomeninges. We present evidence for medulloblastoma circulating tumor cells (CTCs) in therapy-naive patients and demonstrate in vivo, through flank xenografting and parabiosis, that medulloblastoma CTCs can spread through the blood to the leptomeningeal space to form leptomeningeal metastases...
February 22, 2018: Cell
https://www.readbyqxmd.com/read/29462368/dural-cells-release-factors-which-promote-cancer-cell-malignancy-and-induce-immunosuppressive-markers-in-bone-marrow-myeloid-cells
#2
Nicholas J Szerlip, Alexandra Calinescu, Eleanor Smith, Rebecca Tagett, Katrina L Clines, Henry H Moon, Russell S Taichman, Catherine H Van Poznak, Gregory A Clines
BACKGROUND: Thirty per cent of cancer patients develop spine metastases with a substantial number leading to spinal cord compression and neurological deficits. Many demonstrate a propensity toward metastasis to the posterior third of the vertebral body. The dura, the outer layer of the meninges, lies in intimate contact with the posterior border of the vertebral body and has been shown to influence adjacent bone. The effects of the dura on bone marrow and cancer cells have not been examined...
February 15, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29455490/-clinical-application-of-anterior-thoracoscopically-assisted-surgery-with-posterior-one-stage-total-en-block-spondylectomy-for-thoracic-spinal-tumor
#3
Wen Xue, Xiao-Li Guan, Zeng-Ping Wang, Zhong-Yu Hao, Lin Liu, Yao-Wen Qian
OBJECTIVE: To investigate the clincial effects and feasibility of anterior thoracoscopically assisted surgery (TAS) with posterior one-stage total en block spondylectomy(TES) for thoracic spinal tumour. METHODS: From October 2014 to January 2016, 4 patients with thoracic spinal tumour were treated by anterior thoracoscopically assisted surgery with posterior one-stage total en block spondylectomy. There were 2 males and 2 females, aged 16, 35, 46, 60 years. Courses of disease were 1, 4, 6, 9 months...
September 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29429888/risk-factors-for-local-recurrence-after-total-en-bloc-spondylectomy-for-metastatic-spinal-tumors-a-retrospective-study
#4
Takashi Igarashi, Hideki Murakami, Satoru Demura, Satoshi Kato, Katsuhito Yoshioka, Noriaki Yokogawa, Hiroyuki Tsuchiya
BACKGROUND: The aim of this study was to evaluate local recurrence and survival outcomes after frozen autograft total en bloc spondylectomy for metastatic spinal tumors. METHODS: We retrospectively analyzed data from 91 patients with metastatic spinal tumors who underwent frozen autograft total en bloc spondylectomy at our institution between May 2010 and April 2015. We assessed the incidence, primary cancer type, and sites of local recurrence. Risk factors for local recurrence were also examined through the statistical analysis of 17 items, including clinico-pathological characteristics, treatment history, and preoperative or surgical complications...
February 8, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29429358/-change-of-paradigm-in-the-surgical-treatment-of-metastatic-diseases-of-the-bone-part-ii-treatment-of-spinal-metastases
#5
Áron Lazáry, Zsolt Szövérfi, Péter Pál Varga
The incidence of spinal metastases is constantly growing, but due to the advancements in oncologic treatment methods, the survival and the quality of life of the patients are persistently improving. Choosing the optimal treatment method is essential, and several factors should be considered: type of the primary tumor, segmental stability, the symptoms caused by the metastasis and the general condition of the patient. Using modern radiotherapeutic methods combined with minimally invasive surgical techniques (minimally invasive stabilization, separation surgery) in the majority of patients permits adequate local control with low complication rate...
February 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29428421/prognostic-factors-of-surgical-complications-and-overall-survival-of-patients-with-metastatic-spinal-tumor
#6
Gábor Czigléczki, Tamás Mezei, Péter Pollner, Anna Horváth, Péter Banczerowski
OBJECTIVE: Achievements of oncological treatments increase the incidence of spinal metastases. The surgical treatment of spinal metastases results in a high complication rate which must set against the expected benefits. The aim of this article is to summarize an extended database of patients with spinal metastases and to study the effect of several prognostic factors on surgical complications and survival time. METHODS: We designed a retrospective study of 337 patients with spinal metastases who were surgically treated between 2008 and 2015...
February 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29423888/posterolateral-cervical-transpedicular-corpectomy-for-the-surgical-management-of-metastatic-tumor
#7
Martin H Pham, Joshua Bakhsheshian
Management of metastatic spinal disease in the upper cervical spine can be particularly challenging. Depending on the level of the lesion and the patient's anatomy, multiple anterior approaches have been described for resection of the cancer, followed by posterior fixation and instrumentation. Although a single-stage posterolateral approach is now well established for thoracic pathology, less is known about the applicability of these principles when applied as an approach to the cervical spine. The authors present here a case using a posterolateral transpedicular approach for corpectomy and graft placement for circumferential reconstruction as a treatment of metastatic disease in the cervical spine to illustrate the feasibility of this technique, especially in the setting where the patient's anatomy or pathology may impede an anterior or combined circumferential approach...
February 9, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29422106/1x8-gy-versus-5x4-gy-for-metastatic-epidural-spinal-cord-compression-a-matched-pair-study-of-three-prognostic-patient-subgroups
#8
Dirk Rades, Antonio J Conde-Moreno, Jon Cacicedo, Theo Veninga, Barbara Segedin, Karmen Stanic, Volker Rudat, Steven E Schild
BACKGROUND: This study provides separate comparisons of 1 × 8 Gy to 5 × 4 Gy for metastatic epidural spinal cord compression (MESCC) in patients with poor, intermediate and favorable survival prognoses. METHODS: Patients receiving 1 × 8 Gy were matched to patients receiving 5 × 4 Gy for age, gender, performance status, tumor type, involved vertebrae, other bone metastases, visceral metastases, interval between tumor diagnosis and MESCC, ambulatory status and time developing motor deficits...
February 8, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29408300/the-potential-of-minimally-invasive-surgery-to-treat-metastatic-spinal-disease-versus-open-surgery-a-systematic-review-and-meta-analysis
#9
Victor M Lu, Mohammed Ali Alvi, Anshit Goyal, Panagiotis Kerezoudis, Mohamad Bydon
BACKGROUND: and Purpose: Metastasis to the spinal column is a common feature of primary tumors of breast, prostate, lung and other organs. Currently surgical intervention can be performed via the traditional open surgery (OS) approach or the minimally invasive surgery (MIS) approach. This study aims to assess the available evidence of perioperative outcomes of MIS vs OS for metastatic spinal disease patients. METHODS: We followed recommended PRISMA guidelines for systematic reviews...
February 2, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29402333/clinical-results-of-multidisciplinary-therapy-including-palliative-posterior-spinal-stabilization-surgery-and-postoperative-adjuvant-therapy-for-metastatic-spinal-tumor
#10
Hiroshi Uei, Yasuaki Tokuhashi, Masafumi Maseda, Masahiro Nakahashi, Hirokatsu Sawada, Enshi Nakayama, Hirotoki Soma
BACKGROUND: Surgeries performed for metastatic spinal tumor are mostly palliative and are controversial for patients with short life expectancy. We investigated whether palliative posterior spinal stabilization surgery with postoperative multidisciplinary therapy results in improvement of life prognosis and activities of daily living (ADL) in patients with metastatic spinal tumor. METHODS: The subjects were 55 patients who underwent palliative posterior-only instrumentation surgery for metastatic spinal tumor at our hospital between 2012 and 2015...
February 5, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29390489/percutaneous-kyphoplasty-versus-posterior-spinal-fixation-with-vertebroplasty-for-treatment-of-k%C3%A3-mmell-disease-a-case-control-study-with-minimal-2-year-follow-up
#11
Hou-Kun Li, Ding-Jun Hao, Jun-Song Yang, Da-Geng Huang, Cheng-Cheng Yu, Jia-Nan Zhang, Lin Gao, Han Li, Bing Qian
This is a retrospective case-control study.The aim of this study was to compare the surgical results of percutaneous kyphoplasty (KP) and posterior spinal fixation with vertebroplasty (PSF+VP) for treatment of Kümmell disease (KD).KD is rare form of post-traumatic delayed avascular necrosis of the vertebral body. It is reported that KP is an effect measure for treatment of KD. Some studies have recommended posterior spinal fixation with vertebroplasty for KD.A total of 100 patients with KD who underwent spinal surgery at our hospital were enrolled from January 2008 to December 2013...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29382618/primary-meningeal-melanocytoma-in-sellar-region-simulating-a-nonfunctioning-pituitary-adenoma-a-case-report-and-literature-review
#12
Fei Wang, Shiying Ling
BACKGROUND: and Importance Primary meningeal melanocytoma (PMM) is a benign lesion in the central nervous system derived from leptomeningeal melanocytes, most commonly growing in the posterior fossa and cervical spinal cord. The primary sellar melanocytoma is an exceptionally rare tumor. The authors reported the ninth published case of a sellar primary meningeal melanocytoma (SPMM). CLINICAL PRESENTATION: The patient presented only with visual impairment and irregular menstruation without other symptoms...
January 27, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29380526/early-outcomes-and-patterns-of-failure-following-proton-therapy-for-nonmetastatic-intracranial-nongerminomatous-germ-cell-tumors
#13
Meriem Mokhtech, Ronny L Rotondo, Julie A Bradley, Eric S Sandler, Ronica Nanda, Natalie Logie, Philipp R Aldana, Christopher G Morris, Daniel J Indelicato
BACKGROUND: Although dosimetric comparisons demonstrate the advantage of proton therapy (PT) over conventional radiotherapy for nongerminomatous germ cell tumors (NGGCT), clinical outcome data for this rare tumor are lacking. We sought to evaluate outcomes for children with NGGCT treated with PT. METHODS: Between 2007 and 2016, 14 children (median age 11, range, 5-19 years) with nonmetastatic NGGCT were treated with PT after induction chemotherapy. Most (8/14) were mixed germ cell...
January 30, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29375904/chest-wall-a-structure-underestimated-in-ultrasonography-part-iii-neoplastic-lesions
#14
REVIEW
Andrzej Smereczyński, Katarzyna Kołaczyk, Elżbieta Bernatowicz
Chest wall neoplasms mainly include malignancies, metastatic in particular. Differential diagnosis should include clinical data; tumor location, extent, delineation; the degree of homogeneity; the presence of calcifications; the nature of bone destruction and the degree of vascularization. The aim of the paper is to present both the benefits and limitations of ultrasound for the diagnosis of chest wall neoplasms. The neoplastic process may be limited to the chest wall; it may spread from the chest wall into the intrathoracic structures or spread from the inside of the chest towards the chest wall...
December 2017: Journal of Ultrasonography
https://www.readbyqxmd.com/read/29372858/myositis-following-spine-radiosurgery-for-metastatic-disease-a-case-series
#15
Dennis T Lockney, Angela Y Jia, Eric Lis, Natalie A Lockney, Chengbao Liu, Benjamin Hopkins, Daniel S Higginson, Yoshiya Yamada, Ilya Laufer, Mark Bilsky, Adam M Schmitt
OBJECTIVE Spinal stereotactic body radiation therapy (SBRT) has emerged as an attractive method to deliver high doses of radiation to oligometastatic spinal tumors with radioresistant histology. Because SBRT is a palliative therapy, attention to potential radiation toxicities is paramount when counseling patients. The objective of this study was to report radiation-induced myositis after SBRT, a previously undescribed complication. METHODS A total of 667 patients received 891 spine SBRT treatments (either 24 Gy in 1 fraction or 27 Gy in 3 fractions) from 2011 to 2016 and underwent retrospective review...
January 26, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29372846/pathology-of-melanotic-schwannoma
#16
Borislav A Alexiev, Pauline M Chou, Lawrence J Jennings
CONTEXT: - Melanotic schwannoma (MS) is a nerve sheath tumor with a uniform composition of variably melanin-producing Schwann cells and metastatic potential. The MS is an uncommon neoplasm, accounting for less than 1% of all nerve sheath tumors, with a predilection for spinal nerve involvement. Microscopically, the tumors are characterized by spindle and epithelioid cells arranged in interlacing fascicles, with marked accumulation of melanin in neoplastic cells and associated melanophages...
January 26, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29363928/managing-patients-with-oncologic-complications-in-the-emergency-department-digest
#17
David Wacker, Michael T McCurdy, Jeffrey Nusbaum, Nachi Gupta
As the prevalence of cancer continues to increase in the general population and improvements in cancer treatment prolong survival, the incidence of patients presenting to the emergency department with oncologic complications will, similarly, continue to rise. This issue reviews 3 of the more common presentations of oncology patients to the emergency department: metastatic spinal cord compression, tumor lysis syndrome, and febrile neutropenia. Signs and symptoms of these conditions can be varied and nonspecific, and may be related to the malignancy itself or to an adverse effect of the cancer treatment...
January 22, 2018: Emergency Medicine Practice
https://www.readbyqxmd.com/read/29355803/full-endoscopic-interlaminar-approach-for-nerve-root-decompression-of-sacral-metastatic-tumor
#18
Sheng-Hua Tsai, Hsuan-Han Wu, Chun-Yuan Cheng, Chien-Min Chen
BACKGROUND: Endoscopic surgery has been successfully applied in the treatment of degenerative spinal disease, but few studies have assessed its use in treating sacral metastasis. Herein, a successful full endoscopic interlaminar approach for sacral nerve root decompression of a sacral metastatic tumor was presented. CASE DESCRIPTION: An 80-year-old man with history of hepatocellular carcinoma suffered from buttock pain with radiation to the right lower leg for one week...
January 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29350000/-percutaneous-vertebroplasty-and-open-vertebroplasty-for-metastatic-spinal-tumor
#19
Xi-Jiang Zhao, Xin-Sheng Qi, Zhi-Xiang Mao, Quan-Ming Wang, Xiang-Bin Gao, Xian-Jun Zhang
OBJECTIVE: To explore the clinical application and therapeutic effect of percutaneous vertebroplasty(PVP) and open vertebroplasty for metastatic spinal tumor. METHODS: The clinical data of 126 patients with metastatic spinal tumor underwent surgery and obtained follow-up from January 2012 to March 2016 were retrospectively analyzed. These 126 cases were divided into two groups according to different operative methods. The metastatic tumor of 43 cases encroached vertebral canal oppressing spinal cord and nerve root, they were treated with open operation(open vertebroplasty group);and other 83 cases without obviously spinal cord or nerve root compression, or unfit for open operation, were treated with PVP (percutaneous vertebroplasty group) ...
February 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29348828/dose-escalation-by-image-guided-intensity-modulated-radiotherapy-leads-to-an-increase-in-pain-relief-for-spinal-metastases-a-comparison-study-with-a-regimen-of-30-gy-in-10-fractions
#20
Jinlan He, Jianghong Xiao, Xingchen Peng, Baofeng Duan, Yan Li, Ping Ai, Min Yao, Nianyong Chen
Purpose: Under the existing condition that the optimum radiotherapy regimen for spinal metastases is controversial, this study investigates the benefits of dose escalation by image-guided intensity-modulated radiotherapy (IG-IMRT) with 60-66 Gy in 20-30 fractions for spinal metastases. Results: In the dose-escalation group, each D50 of planning gross tumor volume (PGTV) was above 60 Gy and each Dmax of spinal cord planning organ at risk volume (PRV) was below 48 Gy...
December 22, 2017: Oncotarget
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