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https://www.readbyqxmd.com/read/29226425/intraventricular-melanocytoma-diagnosis-confirmed-by-gene-mutation-profile
#1
Ulrich J Knappe, Iris Tischoff, Andrea Tannapfel, Wolf-Dieter Reinbold, Inga Möller, Antje Sucker, Dirk Schadendorf, Klaus G Griewank, Johannes A P van de Nes
Primary leptomeningeal melanocytic tumors (PLMTs) are rare. They usually arise along the spinal cord and at the skull base. Here we report on a patient with a very rare intraventricular melanocytoma. Histologically, a melanocytic tumor was clearly diagnosed. However, to make the uncommon diagnosis of an intraventricular melanocytoma, metastatic melanoma needed to be excluded. Next generation sequencing covering gene mutations that may occur in PLMTs and cutaneous melanoma was performed. The unique gene mutation profile detected, consisting of an activating CYSLTR2 L129Q mutation and EIF1AX G9R mutation and a lack of mutations in genes known to occur in metastatic melanoma (i...
December 11, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/29223525/case-series-of-rare-thymoma-metastases-to-the-spine-and-complete-literature-review
#2
Rebecca L Achey, Bryan S Lee, Swetha Sundar, Edward C Benzel, Ajit A Krishnaney
BACKGROUND: We report a series of three cases of metastatic thymoma to the spine with spinal cord compression. An extensive literature review of thymic metastases to the spine was completed in order to provide a comprehensive appraisal of current prognostic indicators and potential treatment algorithms to help guide clinicians in treatment management. CASE DESCRIPTIONS: Between 2000 and 2017, three patients were diagnosed with thymic metastases to the spine at our institution...
December 6, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29219779/metastases-of-spinal-myxopapillary-ependymoma-unique-characteristics-and-clinical-management
#3
Theresa Kraetzig, Lily McLaughlin, Mark H Bilsky, Ilya Laufer
OBJECTIVE Myxopapillary ependymoma is a benign WHO Grade I tumor most commonly located in the conus-cauda equina region of the spine. Although this tumor is defined by an overall excellent survival, dissemination throughout the whole neuraxis occurs frequently. The current study evaluated the clinical characteristics and significance of myxopapillary ependymoma metastases. METHODS Patients who underwent surgery from 2005 to 2015 for treatment of spinal myxopapillary ependymoma were included in the study. Charts were reviewed for primary tumor symptoms and initial treatment, local recurrence, response to salvage therapy, and presence and behavior of distant metastases...
December 8, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29218482/a-novel-muscle-sparing-high-thoracotomy-for-upper-thoracic-spine-resection-and-reconstruction
#4
Derek T Bernstein, Wu Zhuge, Shanda H Blackmon, Rex A W Marco
PURPOSE: High thoracotomy allows access to the anterior cervicothoracic and upper thoracic vertebrae; however, traditional techniques transect shoulder girdle muscles, leading to postoperative shoulder dysfunction. Muscle-sparing techniques diminish this concern, but often sacrifice the quality of exposure. We describe a novel muscle-sparing, high thoracotomy approach for the treatment of ventral cervicothoracic and upper thoracic spine lesions. METHODS: A novel muscle-sparing, high thoracotomy approach is described, utilizing a midline posterior incision with lateral extension from the lateral decubitus position...
December 7, 2017: European Spine Journal
https://www.readbyqxmd.com/read/29200112/epidemiology-treatment-and-complications-of-central-nervous-system-metastases
#5
Amy A Pruitt
PURPOSE OF REVIEW: Neurologic problems resulting from systemic cancer metastases to brain parenchyma, dura, spinal cord, and leptomeninges are among the most common types of consultations addressed by neurologists. With patients surviving longer from systemic cancer, along with the rapidly evolving therapeutic options, the treatment of these devastating complications has become both more effective and more complicated. This article reviews current patterns of metastatic disease and the increasingly nuanced landscape of evolving therapies, their complications, and their impact on quality of survival...
December 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/29181146/metastatic-prostate-adenocarcinoma-to-intradural-foramen-magnum
#6
Halil Olgun Peker, Nural Cafer Celik, Ulas Cikla, Mustafa K Baskaya
Intradural metastatic tumors are rarely reported in foramen magnum (FM), including cases of melanoma, pituitary carcinoma, thyroid carcinoma, and prostate carcinoma metastases. We report a 68-year-old male who presented with right-sided headache, progressive swallowing difficulty requiring gastrostomy tube and hoarseness over the course of 1 year. Images revealed a heterogeneous, contrast-enhancing lesion in the FM that compressed the anterior aspect of the medulla and upper spinal cord. Although metastatic tumor was considered in differential diagnosis, presumptive diagnosis was FM meningioma due to lack of bone destruction or sclerosis on CT and T2W isointense and T1W hypointense appearance on MRI...
November 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29138883/hallmarks-of-bone-metastasis
#7
REVIEW
Rachelle W Johnson, Larry J Suva
Breast cancer bone metastasis develops as the result of a series of complex interactions between tumor cells, bone marrow cells, and resident bone cells. The net effect of these interactions are the disruption of normal bone homeostasis, often with significantly increased osteoclast and osteoblast activity, which has provided a rational target for controlling tumor progression, with little or no emphasis on tumor eradication. Indeed, the clinical course of metastatic breast cancer is relatively long, with patients likely to experience sequential skeletal-related events (SREs), often over lengthy periods of time, even up to decades...
November 14, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29136257/risk-factors-for-pathological-fracture-and-metastatic-epidural-spinal-cord-compression-in-patients-with-spinal-metastases
#8
Catherine S Hibberd, Gerald M Y Quan
Vertebral pathological fracture and metastatic epidural spinal cord compression (MESCC) due to metastatic cancer inevitably cause pain, neurological deficit, impaired function, and decreased quality of life and are indications for surgery. In such cases, earlier surgical intervention has the potential to prevent permanent neurological deficit and disability and to maintain function and quality of life. Therefore, the aim of this study was to identify and evaluate risk factors for pathological fracture and MESCC in patients with spinal metastases...
November 11, 2017: Orthopedics
https://www.readbyqxmd.com/read/29125440/long-term-outcomes-of-primarily-metastatic-juvenile-pilocytic-astrocytoma-in-children
#9
Derek Yecies, Paul Graham Fisher, Samuel Cheshier, Michael Edwards, Gerald Grant
OBJECTIVE Primarily metastatic juvenile pilocytic astrocytoma (JPA) is rare, likely representing 2%-3% of all cases of JPA. Due to the rarity of primarily metastatic JPA, there is currently no standard treatment paradigm and the long-term outcomes are not fully known. The goal of this case series was to add to the current understanding of this disease process. METHODS The authors searched a comprehensive database of pediatric patients with brain and spinal cord tumors treated at Lucile Packard Children's Hospital from 1997 to 2016 and identified 5 patients with primarily metastatic JPA...
November 10, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29125427/the-surgical-treatment-of-metastatic-spine-tumors-within-the-intramedullary-compartment
#10
Ben A Strickland, Ian E McCutcheon, Indro Chakrabarti, Laurence D Rhines, Jeffrey S Weinberg
OBJECTIVE Metastasis to the spinal cord is rare, and optimal management of this disease is unclear. The authors investigated this issue by analyzing the results of surgical treatment of spinal intramedullary metastasis (IM) at a major cancer center. METHODS The authors retrospectively reviewed the medical records of 13 patients who underwent surgery for IM. Patients had renal cell carcinoma (n = 4), breast carcinoma (n = 3), melanoma (n = 2), non-small cell lung cancer (n = 1), sarcoma (n = 1), adenoid cystic carcinoma (n = 1), and cervical cancer (n = 1)...
November 10, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29124954/practicality-of-using-the-figure-of-eight-bandage-to-prevent-fatal-wound-dehiscence-after-spinal-tumor-surgery-for-upper-thoracic-metastasis
#11
Dong Kwang Seo, Jin-Hoon Park, Sun Kyu Oh, Yongchel Ahn, Sang Ryong Jeon
OBJECT: Serious postoperative wound problems can frequently develop after surgery with perioperative RT for upper thoracic metastatic lesions. The figure-of-eight bandage can restrict excessive shoulder motion, which could prevent wound dehiscence. The purpose of this study was to describe the efficacy of using the figure-of-eight bandage to prevent postoperative wound dehiscence. METHODS: Between February 2005 and July 2015, we retrospectively evaluated the medical records of cancer patients who underwent surgery with or without RT for spinal metastasis involving the upper thoracic spine...
November 10, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29122701/predictors-of-quality-of-life-improvement-after-surgery-for-metastatic-tumors-of-the-spine-prospective-cohort-study
#12
Ori Barzilai, Lily McLaughlin, Mary-Kate Amato, Anne S Reiner, Shahiba Q Ogilvie, Eric Lis, Yoshiya Yamada, Mark H Bilsky, Ilya Laufer
BACKGROUND CONTEXT: Surgical decompression and stabilization followed by radiosurgery represents an effective method for local tumor control and neurologic preservation for patients with metastatic epidural spinal cord compression. We have previously demonstrated improvement in HrQOL after this combined modality treatment ("hybrid therapy"). PURPOSE: The current analysis focuses on delineation of patient-specific prognostic factors predictive of HrQOL change after combined surgery-SRS treatment of MESCC...
November 6, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29113175/correlation-of-mmp-9-and-p53-protein-expression-with-prognosis-in-metastatic-spinal-tumor-of-lung-cancer
#13
Shuquan Zhang, Minfei Wu, Yi Zhao, Rui Gu, Chuangang Peng, Jiabei Liu, Qingsan Zhu, Ye Li
The aim of the study was to compare the protein expression of MMP-9 and p53 and examine their correlation with prognosis in lung cancer metastatic spinal tumor. Tissue samples were obtained from 30 cases of para-cancerous tissue (group I), 75 cases of non-metastatic lung cancer tissue (group II) and 100 cases of metastatic spinal tumor tissue of lung cancer (group III). The protein expression of MMP-9 and p53 was detected by immunohistochemistry and was present in all three groups. The positive rate for MMP-9 was 20, 67 and 83%, respectively...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29109888/melanotic-schwannomas-are-rarely-seen-pigmented-tumors-with-unpredictable-prognosis-and-challenging-diagnosis
#14
Elif Keskin, Sumeyye Ekmekci, Ozgur Oztekin, Gulden Diniz
Melanotic Schwannoma (MS) is rarely seen and potentially malignant neoplasm that is categorized as a variant of Schwannoma. MS most frequently involves intracranial structures followed by posterior nerve roots in the spinal canal. Approximately 50% of the cases with MS have psammomatous calcifications and this type of MS is related to Carney complex with autosomal dominant inheritance. Most cases of MS are benign, though 10% of them are malignant with metastatic potential. MS mimics melanoma and the differential diagnosis should be made excluding other melanin producing neoplasms especially melanoma...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/29104842/concurrent-multiple-myeloma-and-metastatic-osteosarcoma-a-case-report-and-literature-review
#15
Ashley Ramirez, Vincent Grekoski, Michael Valente, Fiona Tissavirasingham, Alessandra Fahey, Nicole Guevara, John W Stelzer, M Joe Ma, Jeremy Burt
Multiple myeloma (MM) and osteosarcoma (OS) are two common bone malignancies, however, the simultaneous occurrence of both primary bone tumors in the same patient has not been reported in the United States to date. We present a unique case in which both malignancies present concurrently in a 72-year-old man. Results of spinal magnetic resonance imaging (MRI), radiographic skeletal survey, and hematological workup established the initial diagnosis of MM. Approximately three months later, the patient was admitted with severe right hip pain and shortness of breath and was evaluated with computed tomography (CT) of the right hip, abdomen, pelvis, and chest, revealing an osseous mass with a "sunburst" pattern in the right hip, and several calcified nodules in the lungs...
August 31, 2017: Curēus
https://www.readbyqxmd.com/read/29028760/the-impact-of-metastatic-spinal-tumor-location-on-30-day-perioperative-mortality-and-morbidity-after-surgical-decompression
#16
Awais K Hussain, Khushdeep S Vig, Zoe B Cheung, Kevin Phan, Mauricio C Lima, Jun S Kim, Deepak A Kaji, Varun Arvind, Samuel Kang-Wook Cho
STUDY DESIGN: A retrospective cohort study from 2011 to 2014 was performed using the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database. OBJECTIVE: The purpose of this study was to assess the impact of tumor location in the cervical, thoracic, or lumbosacral spine on 30-day perioperative mortality and morbidity after surgical decompression of metastatic extradural spinal tumors. SUMMARY OF BACKGROUND DATA: Operative treatment of metastatic spinal tumors involves extensive procedures that are associated with significant complication rates and healthcare costs...
October 12, 2017: Spine
https://www.readbyqxmd.com/read/29021684/use-of-c2-vertebroplasty-and-stereotactic-radiosurgery-for-treatment-of-lytic-metastasis-of-the-odontoid-process
#17
Casey Alicen Hribar, Deb A Bhowmick
Improvements in cancer therapy have led to increased patient survival times in spite of metastatic spinal disease in many forms of cancer. Conventional treatment methods often employ radiotherapy with or without surgery depending on the neurological status, mechanical instability, and the extent of tumor. Percutaneous vertebroplasty as well as stereotactic radiosurgery (SRS) have arisen as common modalities of treatment of spinal metastasis in which neurological compromise or spinal instability and deformity is not of significant concern...
July 2017: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/29021669/is-there-a-correlation-between-the-spinal-instability-neoplastic-score-and-mechanical-pain-in-patients-with-metastatic-spinal-cord-compression-a-prospective-cohort-study
#18
Rodrigo Ac Cavalcante, Yvens B Fernandes, Romulo Al Marques, Vinícius G Santos, Edésio Martins, Vladimir A Zaccariotti, João B Arruda, Claúdio E Tatsui, Andrei F Joaquim
INTRODUCTION: The decision for selecting patients for surgical treatment of metastatic spinal cord compression (MSCC) is challenging even for experienced surgeons. Recently, the spinal instability neoplastic score (SINS) has been proposed to help surgeons in the evaluation of spinal stability in the setting of spinal metastases. This study aimed to evaluate the correlation between SINS and preoperative visual analog scale (VAS), as well as the pre- and post-operative association of the VAS and neurological function...
July 2017: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/28987846/surgery-and-radiotherapy-for-symptomatic-spinal-metastases-is-more-cost-effective-than-radiotherapy-alone-a-cost-utility-analysis-in-a-u-k-spinal-center
#19
Isobel Turner, Joanne Kennedy, Stephen Morris, Alan Crockard, David Choi
BACKGROUND: Surgery for symptomatic spinal metastases is effective at prolonging ambulation and life, but it can appear costly at first glance. We have studied the difference between the cost of surgery and reimbursement received, and the cost-effectiveness of surgery in a U.K. tertiary referral spinal center. METHODS: A cost-versus-reimbursement and cost-utility analysis was performed in a prospective cohort of patients admitted for surgical treatment of spinal metastases...
October 5, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28969629/decision-support-systems-for-incurable-non-small-cell-lung-cancer-a-systematic-review
#20
D Révész, E G Engelhardt, J J Tamminga, F M N H Schramel, B D Onwuteaka-Philipsen, E M W van de Garde, E W Steyerberg, E P Jansma, H C W De Vet, V M H Coupé
BACKGROUND: Individually tailored cancer treatment is essential to ensure optimal treatment and resource use. Treatments for incurable metastatic non-small cell lung cancer (NSCLC) are evolving rapidly, and decision support systems (DSS) for this patient population have been developed to balance benefits and harms for decision-making. The aim of this systematic review was to inventory DSS for stage IIIB/IV NSCLC patients. METHODS: A systematic literature search was performed in Pubmed, Embase and the Cochrane Library...
October 2, 2017: BMC Medical Informatics and Decision Making
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