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https://www.readbyqxmd.com/read/29462368/dural-cells-release-factors-which-promote-cancer-cell-malignancy-and-induce-immunosuppressive-markers-in-bone-marrow-myeloid-cells
#1
Nicholas J Szerlip, Alexandra Calinescu, Eleanor Smith, Rebecca Tagett, Katrina L Clines, Henry H Moon, Russell S Taichman, Catherine H Van Poznak, Gregory A Clines
BACKGROUND: Thirty per cent of cancer patients develop spine metastases with a substantial number leading to spinal cord compression and neurological deficits. Many demonstrate a propensity toward metastasis to the posterior third of the vertebral body. The dura, the outer layer of the meninges, lies in intimate contact with the posterior border of the vertebral body and has been shown to influence adjacent bone. The effects of the dura on bone marrow and cancer cells have not been examined...
February 15, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29446706/a-3d-finite-element-model-of-prophylactic-vertebroplasty-in-the-metastatic-spine-vertebral-stability-and-stress-distribution-on-adjacent-vertebrae
#2
Alessandra Berton, Giuseppe Salvatore, Hugo Giambini, Mauro Ciuffreda, Umile Giuseppe Longo, Vincenzo Denaro, Andrew Thoreson, Kai-Nan An
Background and Objective Patients with metastatically compromised vertebra can experience pathologic fracture with relevant neurological complications. Vertebroplasty is a low cost procedure and it can potentially prevent neurologic impairment if performed at an early stage. The aim of this study is to evaluate the effects of prophylactic vertebroplasty on stability of the metastatic spine and analyze load distribution at adjacent vertebrae. Setting A 3D finite element model of two spinal motion segments (L3-L5) was developed...
February 15, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29439885/early-tissue-effects-of-stereotactic-body-radiation-therapy-for-spinal-metastases
#3
Jasper G Steverink, Stefan M Willems, Marielle E P Philippens, Nicolien Kasperts, Wietse S C Eppinga, Anne L Versteeg, Joanne M van der Velden, Salman Faruqi, Arjun Sahgal, Jorrit-Jan Verlaan
PURPOSE: Stereotactic body radiation therapy (SBRT) is a highly effective and potentially ablative treatment for complex spinal metastases. Recent data have suggested radiobiologic effects of SBRT that expand beyond the traditional concept of DNA damage. Antitumor immunity, vascular damage leading to tumor necrosis, and increased rates of tumor apoptosis have been implied; however, in-human evidence remains scarce. The present study reports unique pathologic confirmation of SBRT-induced biological effects within spinal metastases treated with preoperative SBRT...
January 6, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29434454/sequential-spinal-and-intracranial-dural-metastases-in-gastric-adenocarcinoma-a-case-report
#4
Hongsik Kim, Kyung Sik Yi, Won-Dong Kim, Seung-Myoung Son, Yaewon Yang, Jihyun Kwon, Hye Sook Han
Dural metastasis from primary gastric adenocarcinoma has been rarely reported, and its prognosis is very poor because it frequently leads to acute subdural hematoma. Here, we describe a case with sequential spinal and cranial dural metastases from gastric adenocarcinoma without subdural hematoma. A 43-year-old woman with gastric adenocarcinoma and well-controlled peritoneal carcinomatosis presented with back pain, right radiating leg pain, left facial palsy, and hearing loss. Magnetic resonance imaging of the spine and brain revealed dural masses at the lumbosacral junction with invasion to the L5 and S1 nerve roots and at the skull base with invasion to the internal auditory canal...
February 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29429358/-change-of-paradigm-in-the-surgical-treatment-of-metastatic-diseases-of-the-bone-part-ii-treatment-of-spinal-metastases
#5
Áron Lazáry, Zsolt Szövérfi, Péter Pál Varga
The incidence of spinal metastases is constantly growing, but due to the advancements in oncologic treatment methods, the survival and the quality of life of the patients are persistently improving. Choosing the optimal treatment method is essential, and several factors should be considered: type of the primary tumor, segmental stability, the symptoms caused by the metastasis and the general condition of the patient. Using modern radiotherapeutic methods combined with minimally invasive surgical techniques (minimally invasive stabilization, separation surgery) in the majority of patients permits adequate local control with low complication rate...
February 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29428421/prognostic-factors-of-surgical-complications-and-overall-survival-of-patients-with-metastatic-spinal-tumor
#6
Gábor Czigléczki, Tamás Mezei, Péter Pollner, Anna Horváth, Péter Banczerowski
OBJECTIVE: Achievements of oncological treatments increase the incidence of spinal metastases. The surgical treatment of spinal metastases results in a high complication rate which must set against the expected benefits. The aim of this article is to summarize an extended database of patients with spinal metastases and to study the effect of several prognostic factors on surgical complications and survival time. METHODS: We designed a retrospective study of 337 patients with spinal metastases who were surgically treated between 2008 and 2015...
February 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29423169/a-rare-case-of-spinal-cord-compression-due-to-cervical-spine-metastases-from-paraganglioma-of-the-jugular-foramen-how-should-it-be-treated
#7
Stylianos Kapetanakis, Danai Chourmouzi, Grigorios Gkasdaris, Vasileios Katsaridis, Eleftherios Eleftheriadis, Panagiotis Givissis
Paragangliomas are benign neoplasms that arise from the autonomic nervous system and the associated paraganglia. Although benign, they have been shown to possess metastatic potential. Involvement of the spine is rare. Even rarer is considered the involvement of the cervical spine. We report a case of a patient with a history of an extra-adrenal non-functional paraganglioma of the jugular foramen which was initially treated with intra-arterial embolization. After a 3-year disease-free follow-up, the patient was presented with symptoms of spinal cord compression due to spinal metastases in C2 and C3 vertebrae...
February 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29409889/analysis-of-four-scoring-systems-for-the-prognosis-of-patients-with-metastasis-of-the-vertebral-column
#8
Péter Pollner, Anna Horváth, Tamás Mezei, Péter Banczerowski, Gábor Czigléczki
OBJECTIVE: The metastatic spinal diseases are common health problems and there is no consensus on the appropriate treatment of metastases in several conditions. Using clinical measures (e.g. survival time, functional status), the prognosis prediction systems advise on the appropriate interventions. The aim of this article is to assess and compare four widely used scoring systems (revised Tokuhashi, Tomita, Van der Linden and modified Bauer scores) on a single center cohort. METHODS: A retrospective study of 329 patients was designed who were subjected to surgeries because of metastatic spinal diseases...
January 31, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29408300/the-potential-of-minimally-invasive-surgery-to-treat-metastatic-spinal-disease-versus-open-surgery-a-systematic-review-and-meta-analysis
#9
Victor M Lu, Mohammed Ali Alvi, Anshit Goyal, Panagiotis Kerezoudis, Mohamad Bydon
BACKGROUND: and Purpose: Metastasis to the spinal column is a common feature of primary tumors of breast, prostate, lung and other organs. Currently surgical intervention can be performed via the traditional open surgery (OS) approach or the minimally invasive surgery (MIS) approach. This study aims to assess the available evidence of perioperative outcomes of MIS vs OS for metastatic spinal disease patients. METHODS: We followed recommended PRISMA guidelines for systematic reviews...
February 2, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29407041/high-bone-mass-in-adults
#10
Julien Paccou, Laetitia Michou, Sami Kolta, Françoise Debiais, Bernrard Cortet, Pascal Guggenbuhl
A finding of high bone mineral density (BMD) from routine dual-energy X-ray absorptiometry (DXA) screening is not uncommon. No consensus exists about the definition of high BMD, and T-score and/or Z-score cutoffs of ≥+2.5 or ≥+4 have been suggested. The many disorders that can result in high BMD are usually classified based on whether the BMD changes are focal vs. generalized or acquired vs. constitutional. In over half the cases, careful interpretation of the DXA report and images identifies the cause as an artefact (e...
January 30, 2018: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/29402261/biomechanical-effects-of-metastasis-in-the-osteoporotic-lumbar-spine-a%C3%A2-finite-element-analysis
#11
Giuseppe Salvatore, Alessandra Berton, Hugo Giambini, Mauro Ciuffreda, Pino Florio, Umile Giuseppe Longo, Vincenzo Denaro, Andrew Thoreson, Kai-Nan An
BACKGROUND: Cancer patients are likely to undergo osteoporosis as consequence of hormone manipulation and/or chemotherapy. Little is known about possible increased risk of fracture in this population. The aim of this study was to describe the biomechanical effect of a metastatic lesion in an osteoporotic lumbar spine model. METHODS: A finite element model of two spinal motion segments (L3-L5) was extracted from a previously developed L3-Sacrum model and used to analyze the effect of metastasis size and bone mineral density (BMD) on Vertebral bulge (VB) and Vertebral height (VH)...
February 5, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29390464/vascular-spinal-cord-obstruction-associated-with-superior-vena-cava-syndrome-a-case-report-and-literature-review
#12
Xiaoling Zhang, Xinyuan Li, Meihong Meng, Jie Cao, Xiaonan Song, Kangding Liu, Shaokuan Fang
RATIONALE: Superior vena cava syndrome (SVCS) is the obstruction of blood flow through the SVC, causing complete or partial blockade of the collateral circulation of returning venous blood. SVCS is frequently presented with facial, neck, trunk, and upper limbs swelling and so on. However, to the best of our knowledge, the obstruction of the venous return in the spinal veins is rarely a manifestation of SVCS. PATIENT CONCERNS: We presented a rare case of a 52-year-old male patient with 2-month history of progressive right upper limb numbness and swelling and 10-day history of extremities malfunctioning...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29357902/intensity-modulated-radiotherapy-with-integrated-boost-in-patients-with-bone-metastasis-of-the-spine-study-protocol-for-a-randomized-controlled-trial
#13
Tanja Sprave, Stefan Ezechiel Welte, Thomas Bruckner, Robert Förster, Tilman Bostel, Ingmar Schlampp, Nils Henrik Nicolay, Jürgen Debus, Harald Rief
BACKGROUND: Stereotactic body radiation therapy (SBRT) using intensity-modulated radiotherapy (IMRT) with dose escalation by simultaneous integrated boost (SIB) can be a safe modality for treating spinal bone metastases with enhanced targeting accuracy and improve local tumor control. METHODS/DESIGN: This is a single-center, prospective, randomized, controlled trial. One hundred and twenty patients with spinal bone metastases will receive palliative radiation therapy at the Heidelberg University Hospital...
January 22, 2018: Trials
https://www.readbyqxmd.com/read/29355803/full-endoscopic-interlaminar-approach-for-nerve-root-decompression-of-sacral-metastatic-tumor
#14
Sheng-Hua Tsai, Hsuan-Han Wu, Chun-Yuan Cheng, Chien-Min Chen
BACKGROUND: Endoscopic surgery has been successfully applied in the treatment of degenerative spinal disease, but few studies have assessed its use in treating sacral metastasis. Herein, a successful full endoscopic interlaminar approach for sacral nerve root decompression of a sacral metastatic tumor was presented. CASE DESCRIPTION: An 80-year-old man with history of hepatocellular carcinoma suffered from buttock pain with radiation to the right lower leg for one week...
January 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29355789/surgical-site-infection-in-spinal-metastasis-incidence-and-risk-factors
#15
Amer Sebaaly, Daniel Shedid, Ghassan Boubez, Fahed Zairi, Michelle Kanhonou, Sung-Joo Yuh, Zhi Wang
BACKGROUND: Surgical site infection (SSI) inspinal metastasis surgery represents the most common postoperative surgical complication with high morbidity and mortality. OBJECTIVE: Evaluate the incidence of SSI in spinal metastasis surgery and its risk factors. STUDY DESIGN: Retrospective analysis of a prospective collected data. METHODS: Preoperative, operative and post-operative data were collected together with the Modified Tokuhashi score and Frankel score at all time checkpoints...
January 17, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29354752/primary-leiomyosarcoma-of-the-spine-treated-with-total-en-bloc-spondylectomy-the-first-case-in-thailand-a-case-report-and-literature-review
#16
Tinnakorn Pluemvitayaporn, Chaiwat Piyaskulkaew, Sombat Kunakornsawat, Pritsanai Pruttikul
Leiomyosarcoma is a rare type of malignant soft tissue tumor and also one of the most aggressive soft tissue sarcomas. It commonly occurs in uterus, abdominal viscera, retroperitoneal space and soft tissue of the extremities. Primary osseous leiomyosarcoma is a rare condition. Furthermore, primary leiomyosarcoma of the spine is extremely rare. Only few cases have been reported. However, the treatment and outcomes remains controversial. Therefore, the objective of this case report is to illustrate the management of this extremely rare disease by using total en bloc spondylectomy (TES) procedure, which is one of a suitable option for surgical resection of the spinal tumors...
December 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29349614/treatment-and-outcomes-of-28-patients-with-spinal-metastasis-from-gynecological-cancer
#17
Xin Gao, Chenglong Zhao, Shaohui He, Tianqi Fan, Wei Xu, Cheng Yang, Tielong Liu, Jianru Xiao
The aim of this study was to provide some useful information concerning clinical characteristics, surgical treatment, potential contributing factor and prognostic factors for patients with gynecological cancer (GC) spinal metastasis. We reviewed 28 patients with GC spinal metastasis in our spine tumor center between July 2008 and July 2015. Surgeries were performed on 22 of them. Univariate and multivariate analyses were conducted to identify potential prognostic factors affecting spinal metastasis-free survival (SMFS) and overall survival...
January 18, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29325948/spinal-metastasis-resulting-from-atypical-thymic-carcinoid-a-case-report
#18
Xinjie Wu, Yingna Qi, Feng Yang, Mingsheng Tan, Jie Lin
BACKGROUND: Thymic carcinoid with spinal metastasis is an extremely rare entity. Clinically, the tumor presents either by its endocrine manifestations or by mechanical compression of surrounding structures. However, no previous studies reported a case with neck pain, and neurological deficit as initial presentation of an atypical thymic carcinoid. METHOD: A 56-year-old non-smoking man presented with 12-month history of intermittent neck pain and 1-month history of progressive numbness and weakness of the right upper limb...
January 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29306380/caring-for-patients-with-spinal-metastasis-during-an-mri-examination
#19
T Strand, E Törnqvist, M Rask, Å Roxberg
INTRODUCTION: Magnetic resonance imaging (MRI) is without question the best tool used for diagnosing and evaluating spinal metastasis. An MRI examination is known to be of great value for the treatment planning and survival of these patients. Radiographers have an important role in how the quality of care is experienced by the patients during an MRI examination. The purpose of the study was to describe the radiographers' perceptions of caring for patients with spinal metastasis during an examination with MRI...
February 2018: Radiography
https://www.readbyqxmd.com/read/29301178/epidural-metastasis-in-malignant-thymoma-mimicking-epidural-abscess-case-report-and-literature-review
#20
Ji Yoon Kim, Young Seok Lee, Dong Ho Kang, Min Hye Kim, Jeong Hee Lee, Chul Hee Lee, In Sung Park
Thymoma and thymic carcinoma are rare epithelial tumors that originate from the thymus gland. Extrathoracic metastases occur in the liver, kidney, and bone in 1% to 15% of patients. Although thymoma and thymic carcinoma exhibit highly aggressive biological behavior, spinal metastasis is rare. We describe a 78-year-old man with left wrist and grasp weakness that occurred 7 days before admission. The patient underwent thymoma surgery 7 years ago and was cured. Magnetic resonance images showed a rim-enhanced mass in the C6-7-T1 epidural space...
December 2017: Korean Journal of Spine
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