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https://www.readbyqxmd.com/read/27905158/metastatic-spinal-cord-compression-from-basal-cell-carcinoma-of-the-skin-treated-with-surgical-decompression-and-vismodegib-case-report-and-review-of-hedgehog-signalling-pathway-inhibition-in-advanced-basal-cell-carcinoma
#1
J McGrane, S Carswell, T Talbot
We report a case of a 66-year-old man with locally advanced and metastatic basal cell carcinoma (BCC) causing spinal cord compression, which was treated with spinal surgery and subsequent vismodegib. The patient presented with a large fungating chest wall lesion and a metastasis in T8 that was causing cord compression. He had neurosurgical decompression of the T8 lesion and fixation of the spine. Punch biopsy from the fungating chest wall lesion showed a BCC with some malignant squamous differentiation (basosquamous)...
November 30, 2016: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27867924/metastatic-intracranial-hemangiopericytoma-to-the-spinal-column-a-case-report
#2
Myung Sung Joo, Young Joon Rho, Sang Woo Song, Young-Cho Koh, Hong Gee Roh, So-Dug Lim
Intracranial hemangiopericytoma (HPC) is a rare brain tumor with aggressive biologic behavior associated with high recurrence rate and often with extracranial metastasis. The most common sites of extracranial metastasis of the intracranial HPC are the long bones, lung, liver and abdominal cavity in the order of frequencies. Extracranial metastases usually occur long after the initial diagnosis of the primary tumor. Metastatic intracranial HPC to the vertebra has been rarely reported. We present a case of intracranial HPC metastasized to the L2 vertebral body 13 years after multiple surgical resections and radiotherapy of the primary intracranial HPC...
October 2016: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/27861327/spinal-laser-interstitial-thermal-therapy-a-novel-alternative-to-surgery-for-metastatic-epidural-spinal-cord-compression
#3
Claudio E Tatsui, Sun-Ho Lee, Behrang Amini, Ganesh Rao, Dima Suki, Marilou Oro, Paul D Brown, Amol J Ghia, Shreyas Bhavsar, Keyuri Popat, Laurence D Rhines, R Jason Stafford, Jing Li
BACKGROUND: Although surgery followed by radiation effectively treats metastatic epidural compression, the ideal surgical approach should enable fast recovery and rapid institution of radiation and systemic therapy directed at the primary tumor. OBJECTIVE: To assess spinal laser interstitial thermotherapy (SLITT) as an alternative to surgery monitored in real time by thermal magnetic resonance (MR) images. METHODS: Patients referred for spinal metastasis without motor deficits underwent MR-guided SLITT, followed by stereotactic radiosurgery...
December 2016: Neurosurgery
https://www.readbyqxmd.com/read/27843513/bilateral-choroidal-metastases-from-endobronchial-carcinoid-treated-with-somatostatin-analogues
#4
Deborah De Bruyn, Jan Lamont, Erik Vanderstraeten, Simon Van Belle, Elise Platteau, Julie De Zaeytijd, Kristien P Hoornaert
OBJECTIVE: To describe a patient with bilateral multifocal choroidal metastases from an endobronchial carcinoid treated with a somatostatin analogue. METHOD: A 60-year-old woman presenting with photopsia in the left eye underwent an extensive ophthalmic examination, including fluorescein angiography, OCT and ultrasound. RESULTS: Fundoscopy revealed a small retinal tear in the left eye, for which she received laser treatment. In addition, choroidal masses were detected in both eyes...
2016: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/27837318/astrocytes-in-migration
#5
Jiang Shan Zhan, Kai Gao, Rui Chao Chai, Xi Hua Jia, Dao Peng Luo, Guo Ge, Yu Wu Jiang, Yin-Wan Wendy Fung, Lina Li, Albert Cheung Hoi Yu
Cell migration is a fundamental phenomenon that underlies tissue morphogenesis, wound healing, immune response, and cancer metastasis. Great progresses have been made in research methodologies, with cell migration identified as a highly orchestrated process. Brain is considered the most complex organ in the human body, containing many types of neural cells with astrocytes playing crucial roles in monitoring normal functions of the central nervous system. Astrocytes are mostly quiescent under normal physiological conditions in the adult brain but become migratory after injury...
November 11, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27820732/a-rare-intramedullary-spinal-cord-metastasis-from-a-retroperitoneal-leiomyosarcoma-presenting-as-a-non-traumatic-spinal-cord-injury
#6
Andrew Lamberth Parker, Terrence Pugh, Mark A Hirsch
Leiomyosarcoma (LMS) is a rare but well-recognized malignant soft tissue sarcoma of smooth muscle origin. Metastases commonly occur in the lungs, liver, kidney, brain, and bone. Cases of metastatic osseous lesions or other extradural space-occupying masses secondary to LMS leading to neurologic compromise are relatively commonplace in the literature. Conversely, cases of intramedullary spinal cord metastasis (ISCM), an unusual entity as a sequela of any cancer, are exceedingly rare as a consequence of LMS. Only 2 cases of an ISCM from LMS are currently documented in the literature, and to the best of our knowledge, no case is described in the rehabilitation literature...
November 4, 2016: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/27819871/atypical-notochordal-cell-tumors-a-series-of-notochordal-derived-tumors-that-defy-current-classification-schemes
#7
Jodi M Carter, Doris E Wenger, Peter S Rose, Carrie Y Inwards
By the current WHO classification, benign notochordal cell tumor (BNCT) and chordoma comprise the entire spectrum of notochordal-derived tumors. They have defined radiologic and histologic criteria, and differ considerably in management and clinical outcome. Chordomas are malignant tumors; they show progressive, destructive growth and have the capacity for metastasis. In contrast, BNCT are benign and show limited intraosseous growth. Patients with BNCT can be managed with serial imaging or conservative excision, whereas patients with spinal/sacral chordomas typically undergo radical en bloc resection often with adjuvant therapy and significant morbidity...
November 4, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27813458/a-systematic-review-of-overall-survival-in-pediatric-primary-glioblastoma-multiforme-of-the-spinal-cord
#8
Subhas K Konar, Shyamal C Bir, Tanmoy K Maiti, Anil Nanda
OBJECTIVE The incidence of primary spinal cord glioblastoma multiforme (GBM) in the pediatric age group is very rare. Only a few case series and case reports have been published in the literature; therefore, overall survival (OS) outcome and the as-yet poorly defined management options are not discussed in detail. The authors performed a cumulative survival analysis of all reported cases of pediatric spinal cord GBM to identify the predictive factors related to final survival outcome. METHODS A comprehensive search for relevant articles was performed on PubMed's electronic database MEDLINE for the period from 1950 to 2015 using the search words "malignant spinal cord tumor" and "spinal glioblastoma multiforme...
November 4, 2016: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/27811013/characteristics-of-a-thyroid-carcinoma-cell-line-derived-from-spinal-metastasis
#9
Zhenhua Zhou, Yan Li, Xu Yan, Xudong Wang, Su Chen, Jianru Xiao
A thyroid carcinoma cell line named THY28 was established through primary culture of the surgical specimens, which were derived from a Chinese patient with spinal metastasis. The cell morphology, growth kinetics, cell cycle, chromosome number, cell capability of migration, tumorigenicity, cytogenetic features of the cell line were investigated. THY28 cells were  subcultured in vitro for more than 50 passages with a human karyotype. The modal number of its chromosomes was mainly from 67 to 85. The doubling time of THY28 cells was 56 hours...
November 3, 2016: Bioscience Reports
https://www.readbyqxmd.com/read/27807777/micro-invasive-surgery-combined-with-intraoperative-radiotherapy-for-the-treatment-of-spinal-metastasis
#10
Keng Chen, Lin Huang, Zhaopeng Cai, Juntian Shi, Kaiyun You, Huiyong Shen
PURPOSE: This is a retrospective analysis of the strategy and clinical results of surgery combined with intraoperative radiotherapy (IORT) to treat spinal metastases. METHODS: We delivered tumour-conformal IORT in 40 patients with 52 metastatic vertebrae based on our surgical classification system. The strategies were evaluated with respect to neurologic function and spinal stability. The EORTC QLQ-BM22, visual analogue scale (VAS) and the Frankel Scale were used to assess quality of life, pain and neurologic function...
November 2, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27797240/prevalence-and-survival-patterns-of-patients-with-bone-metastasis-from-common-cancers-in-thailand
#11
Areerak Phanphaisarn, Jayantorn Patumanond, Jongkolnee Settakorn, Parunya Chaiyawat, Jeerawan Klangjorhor, Dumnoensun Pruksakorn
BACKGROUND: Bone metastasis is a single condition but presents with various patterns and severities. Skeletal- related events (SREs) deteriorate overall performance status and reduce quality of life. However, guidelines for early detection and management are limited. This study includes a survey of the prevalence of bone metastasis in cases with common cancers in Thailand as well as a focus on survival patterns and SREs. MATERIALS AND METHODS: A retrospective cohort analysis was conducted using a database of the Chiang Mai Cancer Registry and the Musculoskeletal Tumor Registry of the OLARN Center, Chiang Mai University...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27787590/-68-ga-psma-pet-ct-with-mri-fusion-spinal-cord-metastasis-from-prostate-cancer
#12
Werner Langsteger, Friedrich Fitz, Alireza Rezaee, Hans Geinitz, Mohsen Beheshti
No abstract text is available yet for this article.
October 27, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27785357/perioperative-regional-anaesthesia-and-postoperative-longer-term-outcomes
#13
REVIEW
Jan Jakobsson, Mark Z Johnson
Regional anaesthesia provides effective anaesthesia and analgesia in the perioperative setting. Central neuraxial blocks-that is, spinal and epidural blocks-are well established as an alternative or adjunct to general anaesthesia. Peripheral blocks may be used as part of multimodal anaesthesia/analgesia in perioperative practice, reducing the need for opioid analgesics and enhancing early recovery. Furthermore, regional anaesthesia has increased in popularity and may be done with improved ease and safety with the introduction of ultrasound-guided techniques...
2016: F1000Research
https://www.readbyqxmd.com/read/27781486/quality-of-tri-co-60-mr-igrt-treatment-plans-in-comparison-with-vmat-treatment-plans-for-spine-sabr
#14
Chang Heon Choi, So-Yeon Park, Jung-In Kim, Jin Ho Kim, Kyubo Kim, Joel Carlson, Jong Min Park
OBJECTIVES: To investigate the plan quality of tri-Co-60 intensity-modulated radiation therapy (IMRT) plans for spine stereotactic ablative radiotherapy (SABR). METHODS: A total of 20 patients with spine metastasis were retrospectively selected. For each patient, a tri-Co-60 IMRT plan and a volumetric modulated arc therapy (VMAT) plan were generated. The spinal cords were defined based on magnetic resonance images for the tri-Co-60 IMRT, while isotropic 1 mm margins were added to the spinal cords for the VMAT plans...
October 26, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27771479/surgical-management-for-destructive-atlantoaxial-spondyloarthropathy-in-long-term-hemodialysis-patients
#15
Je Hoon Jeong, Hee Kyung Kim, Soo Bin Im
BACKGROUND: Atlantoaxial spondyloarthropathy is most often resulted from rheumatoid arthritis, cancer metastasis and basilar invagination. Dialysis-related spondyloarthropathy is a rare cause of spinal deformity and cervical myelopathy at the atlantoaxial joint. We report two long-term hemodialysis patients who presented with atlantoaxial spondyloarthropathy. CASE DESCRIPTION: Two patients with end-stage renal failure (ESRD) presented with history of progressively worsening neck pain and motion limitation, and gait disturbance...
October 19, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27768024/our-experience-in-the-treatment-of-vertebral-metastases-from-renal-cell-carcinoma-a-retrospective-study
#16
Giulia R Mosele, Gianfilippo Caggiari, Roberto M Scarpa, Carlo Doria
BACKGROUND: Renal cell carcinoma (RCC) is among the 10 most common cancers in both men and women. It comprises 2-3% of all malignancies. The most common site for metastasis from RCC is the lung (50% of patients), followed by the skeleton (20% to 50% of patients). METHODS: We retrospectively reviewed our consecutive series of 63 patients surgically treated for spinal metastases from RCC. The surgical treatment for spinal metastases varied in each patient. Factors influencing the choice of surgery included age, disease status, symptoms, morbidity of the patient, the location, the number of repetitive lesions and the existence of extra-osseous metastases...
October 21, 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/27764058/prospective-cohort-study-of-performance-status-and-activities-of-daily-living-after-surgery-for-spinal-metastasis
#17
Kenichiro Kakutani, Yoshitada Sakai, Koichiro Maeno, Toru Takada, Takashi Yurube, Takuto Kurakawa, Shingo Miyazaki, Yoshiki Terashima, Masaaki Ito, Hitomi Hara, Teruya Kawamoto, Yasuo Ejima, Akihiro Sakashita, Naomi Kiyota, Yoshiyuki Kizawa, Ryohei Sasaki, Toshihro Akisue, Hironobu Minami, Ryosuke Kuroda, Masahiro Kurosaka, Kotaro Nishida
STUDY DESIGN: A prospective cohort study of performance status (PS) and activities of daily living (ADL) in patients with spinal metastasis. OBJECTIVE: To identify the effect of spinal surgery on PS and ADL in patients with spinal metastasis. SUMMARY OF BACKGROUND DATA: Spinal metastasis causes severe neurological deficits, resulting in drastic loss of patients' PS and ADL. However, the effect of spine surgery on PS and ADL is not well known...
October 19, 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27757435/spinal-myxopapillary-ependymoma-with-interval-drop-metastasis-presenting-as-cauda-equina-syndrome-case-report-and-review-of-literature
#18
Shrikant V Rege, Sharadendu Narayan, Harshad Patil, Abhishek Songara
Myxopapillary ependymoma is a benign slow-growing tumour, arising predominantly in the region of the filum terminale. It has been designated histologically as grade I neoplasm according to the 2007 WHO classification. Despite this benign character dissemination and metastasis along the cerebrospinal axis and metastasis to distant sites have occasionally been reported. There have been previously reported cases of drop metastasis from MPE, however in three of these cases the drop metastasis was diagnosed with concurrent primary spinal MPE...
September 2016: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/27752884/factors-affecting-survival-outcomes-of-patients-with-non-metastatic-ewing-s-sarcoma-family-tumors-in-the-spine-a-retrospective-analysis-of-63-patients-in-a-single-center
#19
Wei Wan, Yan Lou, Zhiqi Hu, Ting Wang, Jinsong Li, Yu Tang, Zhipeng Wu, Leqin Xu, Xinghai Yang, Dianwen Song, Jianru Xiao
Little information has been published in the literature regarding survival outcomes of patients with Ewing's sarcoma family tumors (ESFTs) of the spine. The purpose of this study is to explore factors that may affect the prognosis of patients with non-metastatic spinal ESFTs. A retrospective analysis of survival outcomes was performed in patients with non-metastatic spinal ESFTs. Univariate and multivariate analyses were employed to identify prognostic factors for recurrence and survival. Recurrence-free survival (RFS) and overall survival (OS) were defined as the date of surgery to the date of local relapse and death...
October 17, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27730756/risk-of-skeletal-related-events-among-elderly-prostate-cancer-patients-by-site-of-metastasis-at-diagnosis
#20
Arif Hussain, Abdalla Aly, C Daniel Mullins, Yi Qian, Jorge Arellano, Eberechukwu Onukwugha
The purpose of this study was to estimate the risk of developing skeletal-related events (SREs) based on site of metastasis at diagnosis and identify other predictors of developing SREs among metastatic prostate cancer patients. We conducted a retrospective cohort study using linked SEER (Surveillance, Epidemiology, and End Results) and Medicare data and identified men over the age of 65 with incident metastatic prostate cancer diagnosed during 2005-2009. SREs included radiation (RAD), pathological fractures (PF), bone surgery (BS), and spinal cord compression (SCC)...
November 2016: Cancer Medicine
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