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https://www.readbyqxmd.com/read/29663743/intraspinal-intradural-nodular-fasciitis-mimicking-glioblastoma-metastasis-a-case-report
#1
Carl Moritz Zipser, Lars Füllbier, Rudi Beschorner, Hans Bösmüller, Ulf Ziemann, Marcos Soares Tatagiba, Ghazaleh Tabatabai, Benjamin Bender, Felix Behling
We report the case of a 78-year-old male patient suffering from right temporal glioblastoma with radiographic meningeal tumor spread. During the further course of the disease he developed a rapidly progressive paraplegia. An magnetic resonance imaging scan showed a contrast enhancing an intraspinal intradural lesion with compression of the myelon on segment Th 8/9. With a high suspicion of a spinal metastasis of the known glioblastoma, emergency spinal decompression and resection of the intradural mass was performed...
2018: Folia Neuropathologica
https://www.readbyqxmd.com/read/29663145/successful-treatment-of-a-diffuse-type-tenosynovial-giant-cell-tumor-in-the-thoracic-spine-mimicking-spinal-metastasis-by-frozen-recapping-laminoplasty-in-a-patient-with-thyroid-cancer
#2
REVIEW
Noritaka Yonezawa, Hideki Murakami, Satoshi Kato, Hiroyuki Hayashi, Hiroyuki Tsuchiya
PURPOSE: Tenosynovial giant cell tumor of the diffuse type (TGCT-D) involving the spine is rare. Its differential diagnosis includes metastatic disease; however, there have been few reports of spinal TGCT-D mimicking spinal metastasis in patients with a history of malignancy. METHODS: We report on a 35-year-old woman with a history of papillary thyroid cancer who was diagnosed with TGCT-D of the thoracic spine mimicking spinal metastasis. Preoperative computed tomography (CT) revealed a 1...
April 16, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29661653/radium-223-in-the-treatment-of-bone-metastasis-in-patients-with-castration-resistant-prostate-cancer-review-and-procedure
#3
J Orcajo-Rincon, A P Caresia-Aróztegui, M Del Puig Cózar-Santiago, J R García-Garzón, M de Arcocha-Torres, R C Delgado-Bolton, M J García-Velloso, S Alvarez-Ruiz, A M García-Vicente
Bone metastatic disease is the main cause of morbidity / mortality in patients with prostate cancer, presenting frequently as bone pain, pathological fractures or spinal cord compression, which requires early and timely therapy. Although, for the moment, the therapeutic window for its use has not been definitively established, radium-223 (223 Ra), an alpha particle emitter, has proved to be an effective therapeutic tool, pre or post-chemotherapy, in patients with castration-resistant prostate cancer with symptomatic bone metastases and absence of visceral metastases, significantly modifying the prognosis of the disease...
April 13, 2018: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/29660835/pdgfra-mrna-overexpression-is-associated-with-regional-metastasis-and-reduced-survival-in-oral-squamous-cell-carcinoma
#4
Hui Shan Ong, Sandhya Gokavarapu, Zhen Tian, Jiang Li, Qin Xu, Chen Ping Zhang, Wei Cao
BACKGROUND: Platelet-derived growth factor alpha (PDGFRA) is a gene encoding tyrosine kinase receptor and both EGFR and PDGFRA activate tyrosine kinase. The implication of PGFRA in many cancers and its prognostic significance irrespective to EGFR status in spinal chordoma, gliomas and uterine cancers has shown a need for its investigation in oral squamous cell carcinoma (OSCC). We investigated the prognostic value of PDGFRA mRNA expression in OSCC. PATIENTS AND METHODS: The study was conducted in the department of oral maxillofacial surgery-head and neck oncology, at a tertiary hospital...
April 16, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29625617/analysis-of-prognostic-factors-for-survival-in-patients-with-primary-spinal-chordoma-using-the-seer-registry-from-1973-to-2014
#5
Yue Pan, Lingyun Lu, Junquan Chen, Yong Zhong, Zhehao Dai
BACKGROUND: Spinal chordomas are rare primary osseous tumors that arise from the remnants of the notochord. They are commonly considered slow-growing, locally invasive neoplasms with little tendency to metastasize, but the high recurrent rate of spinal chordomas may seriously affect the survival rate and quality of life of patients. The aim of the study is to describe the epidemiological data and determine the prognostic factors for decreased survival in patients with primary spinal chordoma...
April 6, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29619522/solitary-fibrous-tumour-of-the-spine-imaging-features-of-a-commonly-misdiagnosed-entity
#6
Ning Lang, Enlong Zhang, Xiaoying Xing, Huishu Yuan
OBJECTIVE: Solitary fibrous tumours (SFTs) occurring in the spine are rare. Herein, we review the clinical and imaging data of spinal SFT. METHODS: We retrospectively analysed eight cases of pathologically confirmed spinal SFT imaging and clinical data, pathological manifestations, surgical methods, and follow-up results. RESULTS: Five SFTs cases occurred in the cervical spine, two in the thoracic spine, and one in the lumbosacral spine. Five cases showed a dumbbell-shaped or lobulated soft tissue mass that grew across the intervertebral foramen, two cases showed an expansive intraosseous mass formation in the vertebral body and/or posterior element, and one case showed a long-spindle shaped intraspinal canal mass growing along the spinal canal...
April 4, 2018: European Radiology
https://www.readbyqxmd.com/read/29615371/intraluminal-brachytherapy-boost-following-external-beam-radiotherapy-with-concurrent-chemotherapy-of-oesophagus-carcinoma-results-of-a-prospective-observational-study
#7
P Nag, O P Gurjar, V Bhandari, K L Gupta, P Bagdare, H Goyal
PURPOSE: The main objective of our study is to evaluate response and toxicity profile in patients receiving external beam radiotherapy with concurrent chemotherapy followed by intraluminal brachytherapy boost for a carcinoma of the oesophagus. MATERIAL AND METHODS: Twenty patients with biopsy-proven carcinoma of the oesophagus received external beam radiotherapy (50Gy in 25 fractions) with concurrent chemotherapy (cisplatin: 40mg/m2 ). After a gap of two to three weeks, intraluminal brachytherapy (10Gy in two fractions each 1 week apart by a high dose rate60 Co source) was given...
March 31, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29614357/primary-spinal-cord-melanoma-a-case-report-and-a-systemic-review-of-overall-survival
#8
Mingzhe Zhang, Raynald Liu, Yi Xiang, Jianhui Mao, Guangjie Li, Ronghua Ma, Zhaosheng Sun
BACKGROUND: The incidence of primary spinal cord melanoma (PSCM) is very rare. Several case series and case reports have been published in the literature. However, the predictive factors of PSCM survival and management options are not discussed in detail. METHODS: We present a case of PSCM; total resection was achieved and chemotherapy was given post-operatively. A comprehensive search was performed on PubMed's electronic database using the words "primary spinal cord melanoma"...
March 31, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29599183/embolization-through-the-thyrocervical-trunk-vascular-anatomy-variants-and-a-case-series
#9
Carlos Pérez-García, Carlos Malfaz, Mariano Del Valle Diéguez, Fernando Fortea Gil, Javier Saura Lorente, Miguel Echenagusia Boyra, Manuel González Leyte, Antonio Pérez-Higueras, Enrique Castro-Reyes
BACKGROUND AND PURPOSE: The thyrocervical trunk (TCT) is the second ascending branch of the subclavian artery. It is considered a 'border territory' between interventional vascular radiology and interventional neuroradiology because it gives rise to branches both cervical and to the upper limbs. We describe the TCT branches anatomy, the most frequent variants, and expose eight endovascular procedures performed through the thyrocervical trunk. METHODS: A retrospective review of all the interventional radiology procedures carried out through the TCT in our tertiary care center from August 2014 to January 2017 is presented...
March 29, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29596214/natural-history-and-prognostic-factors-of-cholangiocarcinoma-with-spinal-metastasis-a-10-year-single-center-study
#10
Apiruk Sangsin, Dew Saiudom, Suthipas Pongmanee, Jirawat Saengsin, Taninnit Leerapun, Hideki Murakami
STUDY DESIGN: This is a retrospective analysis. OBJECTIVE: The aim of this study was to determine the epidemiology, survival, and prognostic factors for cholangiocarcinoma (CCA) with spinal metastasis. SUMMARY OF BACKGROUND DATA: CCA is an epithelial cell malignancy of the bile duct, and a frequent site for its metastasis is the spine. Many areas of Asia are endemic for CCAs. To date, there is limited data on the epidemiology, natural history, and prognostic factors of CCA with spinal metastasis, which is crucial for better management and treatment of the disease...
April 2018: Clinical Spine Surgery
https://www.readbyqxmd.com/read/29581777/prospective-matched-study-on-comparison-of-volumetric-modulated-arc-therapy-and-intensity-modulated-radiotherapy-for-nasopharyngeal-carcinoma-dosimetry-delivery-efficiency-and-outcomes
#11
Bin-Bin Chen, Shao-Min Huang, Wei-Wei Xiao, Wen-Zhao Sun, Ming-Zhu Liu, Tai-Xiang Lu, Xiao-Wu Deng, Fei Han
Background: The purpose of this study is to assess the feasibility of volumetric-modulated arc therapy (VMAT) for nasopharyngeal carcinoma (NPC) patients by comparing the physical dosimetry, delivery efficiency and clinical outcomes with intensity-modulated radiotherapy (IMRT). Methods: A prospective matched study was performed for patients with newly diagnosed NPC who underwent VMAT or IMRT. The patients in two groups were equally matched in terms of gender, age, tumor stage and chemotherapy. The target coverage, homogeneity index (HI) and conformity index (CI) of the planning target volume (PTV), organs at risk (OARs) sparing, average treatment time and clinical outcomes were analyzed...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29581018/application-of-morphometrics-as-a-predictor-for-survival-in-patients-with-prostate-cancer-metastasis-to-the-spine
#12
Hesham Mostafa Zakaria, Lara Massie, Azam Basheer, Erinma Elibe, David Boyce-Fappiano, Lonni Shultz, Ian Lee, Brent Griffith, Farzan Siddiqui, Victor Chang
BACKGROUND: Surgery for spinal metastases can improve survival, but has high morbidity that can potentially diminish any benefit. New objective methods of predicting overall survival would be beneficial for surgical decision making. Morphometrics quantifies patient frailty and has been successfully used to predict overall survival in lung cancer patients with spine metastases. This study evaluates whether morphometrics can predict survival in patients with prostate cancer spinal metastases...
March 23, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29576859/effectiveness-and-toxicity-of-conventional-radiotherapy-treatment-for-painful-spinal-metastases-a-detailed-course-of-side-effects-after-opposing-fields-versus-a-single-posterior-field-technique
#13
Paulien G Westhoff, Alexander de Graeff, Evelyn M Monninkhof, Ilse de Pree, Marco van Vulpen, Jan Willem H Leer, Corrie A M Marijnen, Yvette M van der Linden
Background: Conventional radiotherapy for painful spinal metastases can be delivered with a single posterior-anterior (PA) or two opposed anterior-posterior (APPA) fields. We studied the effectiveness and toxicity of both techniques and studied whether treatment technique was predictive for abdominal and skin toxicity. Patients and methods: Within the Dutch Bone Metastasis Study, 343 patients received 8 Gray in a single fraction or 24 Gray in six fractions for painful spinal metastases...
2018: Journal of Radiation Oncology
https://www.readbyqxmd.com/read/29567516/predicting-survival-for-metastatic-spine-disease-a-comparison-of-nine-scoring-systems
#14
A Karim Ahmed, C Rory Goodwin, Amir Heravi, Rachel Kim, Nancy Abu-Bonsrah, Eric Sankey, Daniel Kerekes, Rafael De la Garza Ramos, Joseph Schwab, Daniel M Sciubba
BACKGROUND CONTEXT: Despite advances in spinal oncology, research into patient-based prognostic calculators for metastatic spine disease is lacking. Much of the literature in this area investigates the general predictive accuracy of scoring systems in heterogeneous populations, with few studies considering the accuracy of scoring systems based on patient specifics such as type of primary tumor. PURPOSE: The aim of the current study was to compare the ability of widespread scoring systems to estimate both overall survival at various time points and tumor-specific survival for patients undergoing surgical treatment for metastatic spine disease in order to provide surgeons with information to determine the most appropriate scoring system for a specific patient and timeline...
March 19, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29550605/application-of-morphometrics-as-a-predictor-for-survival-in-female-patients-with-breast-cancer-spinal-metastasis-a-retrospective-cohort-study
#15
Hesham Mostafa Zakaria, Lara Massie, Azam Basheer, David Boyce-Fappiano, Erinma Elibe, Lonni Schultz, Ian Lee, Brent Griffith, Farzan Siddiqui, Victor Chang
BACKGROUND CONTEXT: The current standard of care for prediction of survival of cancer staging is based on TNM staging. However, for patients with spinal metastasis, who all have identical stage IV disease, identifying accurate prognostic markers of survival would allow better treatment stratification between more aggressive treatment strategies or palliation. Analytic morphometrics enables physicians to quantify patient frailty by measuring lean muscle mass. Morphometrics also predicts survival in patients with lung cancer metastases to the spine...
March 14, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29545246/mri-characteristics-of-primary-tumors-and-metastatic-lesions-in-molecular-subgroups-of-pediatric-medulloblastoma-a-single-center-study
#16
D Mata-Mbemba, M Zapotocky, S Laughlin, M D Taylor, V Ramaswamy, C Raybaud
BACKGROUND AND PURPOSE: Molecular grouping of medulloblastoma correlates with prognosis and supports the therapeutic strategy. We provide our experience with the imaging features of primary and metastatic disease in relation to the molecular groups. MATERIALS AND METHODS: One hundred nineteen consecutive patients (mean age, 7.3 ± 3.8 years at diagnosis; male, 79 [66.4%]) with a confirmed diagnosis of medulloblastoma and interpretable pretreatment MRIs were retrieved from our data base from January 2000 to December 2016...
March 15, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29541557/efficacy-of-8-gy-single-fraction-palliative-radiation-therapy-in-painful-bone-metastases-a-single-institution-experience
#17
Muhammad Shuja, Ayman A Elghazaly, Asif Iqbal, Reham Mohamed, Amal Marie, Mutahir A Tunio, Moamen M Aly, Ali Balbaid, Mushabbab Asiri
Introduction Bone metastasis (BM) is a major complication of many solid tumors like breast, prostate, lung and renal cancers. BM leads to serious sequelae of pain, fractures, spinal cord compression and hypercalcemia. Radiotherapy has an established role in relieving pain caused by BM. Worldwide different radiotherapy schedules are being used for BM. The aim of this study is to determine the efficacy of single fraction palliative radiotherapy for painful bone metastases. Methods Between April 2014 and April 2017, single fraction radiotherapy was used to treat 73 patients in our institution...
January 8, 2018: Curēus
https://www.readbyqxmd.com/read/29528810/a-blastema-predominant-canine-renal-nephroblastoma-with-gingival-metastasis-case-report-and-literature-review
#18
Bo Chen, Wen-Ta Li, Fun-In Wang
Nephroblastomas are uncommon embryonal tumors in dogs. We report herein a blastema-predominant nephroblastoma with gingival metastasis in an 8-y-old Miniature Pinscher dog. Histologically, the mass was composed mainly of blastemal elements with minor epithelial and mesenchymal differentiation. Metastatic masses in the gingiva had histologic and immunohistochemical features similar to those of the primary renal nephroblastoma. Neoplastic cells were extensively positive for both vimentin and PAX8, and scattered positive for cytokeratin...
March 1, 2018: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29525980/preoperative-embolization-and-local-hemostatic-agents-in-palliative-decompression-surgery-for-spinal-metastases-of-renal-cell-carcinoma
#19
Nikita Zaborovskii, Dmitrii Ptashnikov, Dmitrii Mikaylov, Sergei Masevnin, Oleg Smekalenkov
BACKGROUND: Intraoperative hemorrhage can sometimes be massive in patients with spinal metastasis of renal cell carcinoma (MRCC). Preoperative embolization and local hemostatic agents are routinely use in spinal tumor surgery, but there have been no comparisons between these methods. This report compares the efficiency of various methods of bleeding control and their influence on outcome and survival after decompression procedures for MRCC. MATERIALS AND METHODS: This was a retrospective case-control study of 54 patients with hypervascular extraosseous MRCC...
March 10, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29507142/teaching-neuroimages-intradural-intramedullary-spinal-cord-metastasis-from-primary-renal-cell-carcinoma
#20
Muhammad Taimur Malik, Syed Jaffar Kazmi, Scott Turner
No abstract text is available yet for this article.
March 6, 2018: Neurology
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