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https://www.readbyqxmd.com/read/29913031/four-year-survival-of-a-patient-with-spinal-metastatic-acinic-cell-carcinoma-after-a-total-en-bloc-spondylectomy-and-reconstruction-with-a-frozen-tumor-bearing-bone-graft
#1
Apiruk Sangsin, Hideki Murakami, Takaki Shimizu, Satoshi Kato, Hiroyuki Tsuchiya
Acinic cell carcinoma metastasizing to the spine is extremely rare. The authors present a case of acinic cell carcinoma of the parotid gland with subsequent lung and spinal metastases, treated with en bloc spondylectomy. A 41-year-old man presented with a left parotid mass. After being diagnosed with acinic cell carcinoma, he underwent a total parotidectomy. Imaging studies revealed a metastatic osteoblastic lesion in the T4 vertebral body and multiple lung metastases. Total en bloc spondylectomy and reconstruction with a frozen tumor-bearing bone graft were performed to treat the T4 metastasis...
June 18, 2018: Orthopedics
https://www.readbyqxmd.com/read/29910637/combined-microwave-ablation-and-minimally-invasive-open-decompression-for-the-management-of-thoracic-metastasis-in-breast-cancer
#2
Bin Liu, Zhenchao Yuan, Chang Yuan Wei
Objective: The incidence rate of thoracic metastasis from breast cancer is increasing. Microwave ablation is one type of clinical therapy used to treat metastatic spine disease, although it can cause protein denaturation and immediate cell death, and coagulative necrosis can occur. Minimally invasive open decompression is associated with lower rates of surgical complications in comparison to traditional open surgery. Therefore, it is an alternative therapeutic option for spinal metastases...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29890702/cellular-and-molecular-mediators-of-bone-metastatic-lesions
#3
REVIEW
Giulia Battafarano, Michela Rossi, Francesco Marampon, Andrea Del Fattore
Bone is the preferential site of metastasis for breast and prostate tumor. Cancer cells establish a tight relationship with the host tissue, secreting factors that stimulate or inhibit bone cells, receiving signals generated from the bone remodeling activity, and displaying some features of bone cells. This interplay between tumor and bone cells alters the physiological bone remodeling, leading to the generation of a vicious cycle that promotes bone metastasis growth. To prevent the skeletal-related events (SRE) associated with bone metastasis, approaches to inhibit osteoclast bone resorption are reported...
June 8, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29881592/merkel-cell-carcinoma-with-intramedullary-spinal-cord-metastasis-a-very-rare-clinical-finding
#4
Tarek Haykal, Basim Towfiq
This clinical image teaches readers that a rare finding such as intramedullary spinal metastasis could exist even in the rarest tumors. It adds to the literature how it was managed. It also might reflect the improvement of our cancer treatment allowing us to follow patients longer to find those rare findings in rare tumors.
June 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29878714/recurrence-of-giant-cell-tumor-of-the-spine-after-resection-a-report-of-10-cases
#5
Peng Lin, Nong Lin, Wangsiyuan Teng, Sheng-Dong Wang, Wei-Bo Pan, Xin Huang, Xiao-Bo Yan, Meng Liu, Heng-Yuan Li, Bing-Hao Li, Ling-Ling Sun, Zhan Wang, Xing-Zhi Zhou, Zhao-Ming Ye
OBJECTIVE: To review the clinical details and further treatments for recurrent spinal giant cell tumors (SGCT), and to analyze the risk factors of recurrence and shed new light on the treatment options and prognosis of recurrent SGCT. METHODS: A retrospective analysis of recurrent SGCT between April 2003 and January 2014 was performed. A total of 10 patients comprising 3 men and 7 women with a mean age of 28.9 years (range, 21-40 years) were included in the study...
May 2018: Orthopaedic Surgery
https://www.readbyqxmd.com/read/29857864/percutaneous-vertebroplasty-in-tumoral-spinal-fractures-with-posterior-vertebral-wall-involvement-feasibility-and-safety
#6
Nicolas Amoretti, Palominos Diego, Pellegrin Amélie, Olivier Andreani, Pauline Foti, Heidy Schmid-Antomarchi, Jean-Claude Scimeca, Pascal Boileau
PURPOSE: to evaluate the technical feasibility and safety of CT and fluoroscopy guided percutaneous vertebroplasty in the treatment of tumoral vertebral fractures with posterior wall involvement. MATERIALS AND METHODS: Institutional review board approval and informed consent were obtained for this study. Sixty-three consecutive adult patients (35 women, 28 men; mean age+/- standard deviation: 69 years+/- 14) with tumoral spinal fractures that compromised the posterior wall were treated by means of percutaneous vertebroplasty with CT and fluoroscopy guidance...
July 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29808457/total-en-bloc-spondylectomy-through-a-posterior-approach-technique-and-surgical-outcome-in-thoracic-metastases
#7
Maurizio Domenicucci, Lorenzo Nigro, Roberto Delfini
BACKGROUND: In 1981, Roy-Camille et al. have firstly reported the total en-bloc spondylectomy (TES) through a posterior approach for cases of malignant spine tumors in order to reduce the local recurrence and to increase the patient's survival. By then, this surgery has been increasingly gaining recognition. However, it requires a high level of technical ability and knowledge of spinal anatomy, physiology, and biomechanics. METHOD: Herein, we report the patient's selection and technique to execute the TES for cases of thoracic metastasis...
July 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29805822/r-inguinal-r-scrotum-extramammary-paget-s-disease-with-diffuse-spine-metastasis-complicated-by-microangiopathic-hemolytic-anemia
#8
Alay Mansurov, Eric Christenson
A 47-year-old male presented with a groin lesion in 2011. Initial treatment with antifungals and vinegar was unsuccessful. In 2016, biopsy of this lesion was pursued with diagnosis of extramammary Paget's disease (EMPD). Prior to the scheduled excision, he developed constant lower back pain with radiation to his lower extremities. MRI confirmed vertebral metastasis. Despite surgical and radiation therapy, his back pain progressed, and repeat imaging showed epidural spread of tumor in the thoracic spine. Later, the patient was admitted to the hospital due to severe anemia and thrombocytopenia...
2018: Case Reports in Hematology
https://www.readbyqxmd.com/read/29802438/-systemic-effects-of-amide-linked-local-anesthetics-old-drugs-new-magic-bullets
#9
REVIEW
T Piegeler, R Werdehausen
Besides the well-known analgesic effects of amide-linked local anesthetics exerted via the inhibition of the voltage-gated sodium channel, these substances also possess a certain number of properties, which bear the potential to positively influence the outcome after surgery. The results of several experimental as well as clinical studies suggest the possibility of an enhanced recovery after surgery, reduction in the incidence of chronic pain, preservation of endothelial barrier function during acute lung injury and the prevention of metastasis of solid tumors by systemic effects of local anesthetic administration...
May 25, 2018: Der Anaesthesist
https://www.readbyqxmd.com/read/29795015/multidisciplinary-approach-for-bone-metastasis-a-review
#10
REVIEW
Takahiro Kimura
Progress in cancer treatment has improved the survival of patients with advanced-stage cancers. Consequently, the clinical courses of patients are prolonged and often accompanied by morbidity due to bone metastases. Skeletal-related events (SREs), such as pathological fractures and spinal paralysis, cause impairment in activities of daily life and quality of life (QOL). To avoid serious SREs causing impairment in QOL and survival, early diagnosis and a prophylactic approach are required. It is necessary to initiate a bone management program concurrently with the initiation of cancer treatment to prevent complications of bone metastasis...
May 24, 2018: Cancers
https://www.readbyqxmd.com/read/29764822/numb-chin-syndrome-an-ominous-sign-of-mandibular-metastasis
#11
Abdul Razak, Bee See Goh, Jothi Raamahlingam Rajaran, Abd Jabar Nazimi
A 51-year-old woman a known case of stage 2 breast carcinoma in 2006 and underwent left mastectomy performed in the same year presented with bilateral lower limb pain suggestive of spinal pathology, and left chin numbness, both of 2 weeks' duration. Examination revealed left mandibular hypoesthesia without any other sign or symptoms. Orthopantomogram was unremarkable apart from mild alveolar bone expansion at tooth 36 area, which was extracted 3 months earlier. Subsequently, a full-body positron emission tomography contrast enhanced computer tomography revealed hypermetabolic lesions of her axial (excluding skull) and appendicular skeleton...
May 14, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29761076/synchronous-bone-metastasis-from-multiple-myeloma-and-prostate-adenocarcinoma-as-initial-presentation-of-coexistent-malignancies
#12
Diego Andres Adrianzen Herrera, Shlomit Goldberg-Stein, Alexander Sankin, Judy Sarungbam, Janaki Sharma, Benjamin A Gartrell
The radiographic appearance of bone metastases is usually determined by tumor histology and can be osteolytic, osteoblastic, or mixed. We present a patient with coexistent bone metastasis from multiple myeloma and prostate adenocarcinoma who exhibited synchronous bone involvement of both histologies within the same bone lesion, a rare phenomenon that has not been previously reported and led to atypical radiographic findings. The radiograph of a 71-year-old man with thigh swelling and pain demonstrated a lytic femoral lesion...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29733989/prognostic-factors-of-ambulatory-status-for-patients-with-metastatic-spinal-cord-compression-a-systematic-review-and-meta-analysis
#13
Yongheng Liu, Yongcheng Hu, Xionggang Yang, Dengxing Lun, Feng Wang, Li Yang, Hao Zhang, Jiangtao Feng, Kunchi Hua
BACKGROUND: This study aimed to identify prognostic factors for functional outcome of metastatic spinal cord compression (MSCC). METHODS: All full texts in English regarding the prognostic factors for functional outcome of MSCC, published between January 2007 and October 2017, were identified using the electronic databases PubMed, Embase, and the Cochrane Library. An exploratory meta-analysis was also conducted when appropriate data were available. RESULT: A total of 25 studies, involving 4897 patients, met the inclusion criteria...
May 4, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29732420/functional-and-survival-outcomes-in-patients-undergoing-surgical-treatment-for-metastatic-disease-of-the-spine
#14
Vignesh K Alamanda, Myra M Robinson, Jeffrey S Kneisl, Joshua C Patt
Background: Retrospective review of a prospective database. Spine metastasis has been shown to occur in 40% of cancer patients with an annual incidence of over 18,000 cases in North America alone. In this study, we sought to explore the functional and survival outcomes of patients undergoing surgical treatment for metastatic disease of the spine. Methods: A retrospective cohort study of a prospective database at a major cancer center was conducted. A total of 55 patients who met the inclusion criteria from January 2010 to December 2015 were included...
March 2018: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29726364/contemporary-statewide-practice-pattern-assessment-of-the-palliative-treatment-of-bone-metastasis
#15
Daniel E Spratt, Brandon R Mancini, James A Hayman, Thomas Boike, Lori J Pierce, Jean M Moran, Michael M Dominello, Mark Fireman, Kent Griffith, Shruti Jolly
PURPOSE: Palliative radiation therapy for bone metastases is often viewed as a single entity, despite national guidelines providing input principally only for painful uncomplicated bone metastases. Data surrounding the treatment of bone metastases are often gleaned from questionnaires of what providers would theoretically do in practice or from population-based data lacking critical granular information. We investigated the real-world treatment of bone metastases with radiation therapy...
June 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29722726/characteristics-and-prognostic-factors-of-bone-metastasis-in-patients-with-colorectal-cancer
#16
Hidetaka Kawamura, Tatsuro Yamaguchi, Yuuta Yano, Takahiro Hozumi, Yasunobu Takaki, Hiroshi Matsumoto, Daisuke Nakano, Keiichi Takahashi
BACKGROUND: Because bone metastasis from colorectal cancer is rare, there are little available data regarding such cases. OBJECTIVE: The study aim was to identify the prognostic factors and characteristics associated with survival in colorectal cancer patients with bone metastasis. DESIGN: This was a retrospective study from a prospectively collected database. SETTINGS: The study took place in a multidisciplinary, high-volume tertiary cancer center in Japan...
June 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29718558/a-simple-staging-system-for-osteosarcoma-performs-equivalently-to-the-ajcc-and-msts-systems
#17
Justin M M Cates
Both the American Joint Committee on Cancer (AJCC) and Musculoskeletal Tumor Society (MSTS) staging systems for skeletal sarcomas have major weaknesses. A revised staging system for osteosarcoma (the Vanderbilt system) was developed based on exploratory analyses of the relative prognostic impacts of histologic grade, tumor size, local tumor extension, and specific anatomic sites of metastasis using case records from the National Cancer Database (N = 4,285). AJCC, MSTS, and Vanderbilt staging schemes were then compared using a separate, population-based cancer registry (the Surveillance, Epidemiology, and End Results database; N = 2,246) as a validation dataset...
May 2, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29703703/assessing-the-utility-of-the-spinal-instability-neoplastic-score-sins-to-predict-fracture-after-conventional-radiation-therapy-rt-for-spinal-metastases
#18
Diana D Shi, Lauren M Hertan, Tai Chung Lam, Sonia Skamene, John H Chi, Michael Groff, Charles H Cho, Marco L Ferrone, Mitchel Harris, Yu-Hui Chen, Tracy A Balboni
PURPOSE: Assessing the stability of spinal metastases is critical for making treatment decisions. The spinal instability neoplastic score (SINS) was developed by the Spine Oncology Study Group to categorize tumor-related lesions; however, data describing its utility in predicting fractures in patients with spinal metastases are limited. The purpose of this study is to assess the validity of SINS in predicting new or worsening fracture after radiation therapy (RT) to spine metastases. METHODS AND MATERIALS: This is a retrospective analysis of patients treated with conventional RT alone (median total dose, 30 Gy; range, 8-47 Gy; median number of fractions, 10; range, 1-25) for spinal metastasis at Dana-Farber/Brigham and Women's Cancer Center from 2006 to 2013...
February 13, 2018: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29703023/serum-irisin-associates-with-breast-cancer-to-spinal-metastasis
#19
Zheng-Ping Zhang, Xue-Fang Zhang, Hui Li, Tuan-Jiang Liu, Qin-Peng Zhao, Lin-Hong Huang, Zi-Jun Cao, Li-Min He, Ding-Jun Hao
The aim of this study was to determine whether the serum level of irisin can be a candidate to predict the spinal metastasis in patients with breast cancer.In a cross-sectional study, 148 patients were recruited. Of those, 53 (35.8%) had spinal metastasis. The baseline characteristics were compared by status of spinal metastasis. Multiple logistic regression analysis was used to determine whether the serum irisin can be a candidate for predicting breast cancer to spinal metastasis. The correlation coefficient analysis was used to confirm the correlation between the serum irisin and lipid metabolic parameters and body mass index (BMI), respectively...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29702311/initial-experience-with-intraoperative-phosphorous-32-brachytherapy-during-resection-of-malignant-spinal-tumors
#20
Cecilia L Dalle Ore, Christopher P Ames, Stephen T Magill, Vedat Deviren, Manish K Aghi, Darryl Lau
INTRODUCTION: Brachytherapy is a major adjuvant modality for neoplasms, but few have trialed its use for spinal tumors. This study examines perioperative and oncologic outcomes of patients with malignant spinal tumors who underwent resection with intraoperative phosphorous-32 (P32) brachytherapy. METHODS: Consecutive adult patients who underwent P32 brachytherapy during malignant spinal tumor resection were retrospectively identified from 2014 to 2015. Complications, tumor recurrence, and survival were reviewed...
April 24, 2018: World Neurosurgery
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