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https://www.readbyqxmd.com/read/28205381/the-clinical-significance-of-equivocal-findings-on-spinal-mri-in-children-with-medulloblastoma
#1
Julie Bennett, Ramy Ashmawy, Vijay Ramaswamy, Derek Stephens, Eric Bouffet, Normand Laperriere, Michael Taylor, Manohar Shroff, Ute Bartels
BACKGROUND: Medulloblastoma (MB) is the most common malignant brain tumor of childhood, with cerebrospinal fluid spread the most common site of metastasis. Currently, children diagnosed with MB and evidence of spinal metastasis are treated with an increased dose of craniospinal radiation (CSI). This report reviewed equivocal abnormalities including nerve root clumping, linear vascular enhancement, nerve root enhancement and/or other vague findings on spinal magnetic resonance imaging (MRI) to elucidate their prognostic significance and aid in risk stratification...
February 16, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28186470/image-guidance-based-on-mri-for-spinal-interstitial-laser-thermotherapy-technical-aspects-and-accuracy
#2
Claudio E Tatsui, Clarissa N G Nascimento, Dima Suki, Behrang Amini, Jing Li, Amol J Ghia, Jonathan G Thomas, R Jason Stafford, Laurence D Rhines, Juan P Cata, Ashok J Kumar, Ganesh Rao
OBJECTIVE Image guidance for spinal procedures is based on 3D-fluoroscopy or CT, which provide poor visualization of soft tissues, including the spinal cord. To overcome this limitation, the authors developed a method to register intraoperative MRI (iMRI) of the spine into a neuronavigation system, allowing excellent visualization of the spinal cord. This novel technique improved the accuracy in the deployment of laser interstitial thermal therapy probes for the treatment of metastatic spinal cord compression...
February 10, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28184002/renal-cell-carcinoma-metastasis-involving-vertebral-hemangioma-dual-percutaneous-treatment-by-navigational-bipolar-radiofrequency-ablation-and-high-viscosity-cement-vertebroplasty
#3
Jean-Baptiste Zerlauth, Reto Meuli, Vincent Dunet
The case of a 70-year-old woman with progressive renal cell carcinoma (RCC) metastatic invasion of a L3 vertebral hemangioma treated by dual percutaneous radiofrequency ablation (RFA) and vertebroplasty is reported. The patient was surgically treated for RCC in 2001. Chemotherapy and immunotherapy were introduced in 2013 for ovarian, bladder and cerebral metastatic disease. An asymptomatic L3 benign hemangioma was noticed at this time. One-year CT and MRI follow-up studies demonstrated a nodular isolated soft tissue lesion involving the anterior edge of the hemangioma...
February 9, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28179707/cervical-chordoma-involving-c3-c4-a-case-report
#4
Muhammad Imran, Atiq Ahmed Khan, Syed Muneeb Younus
Chordoma is a rare, indolent but locally invasive, osteolytic, slow growing, low grade, primary bone malignancy, derived from the embryonic remnants of the notochord. It is a midline tumour and it predominantly emerges from the axial skeleton. The most commonly observed location of a chordoma is in the sacrococcygeal region ( 50 to 55% ) followed by the cranio occipital region ( 25 to 30% )We present a case of a 30 years old lady who came to us with complaints of difficulty in walking and inability to hold objects in both hands...
December 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28162875/diagnosis-of-spinal-lesions-using-heuristic-and-pharmacokinetic-parameters-measured-by-dynamic-contrast-enhanced-mri
#5
Ning Lang, Huishu Yuan, Hon J Yu, Min-Ying Su
RATIONALE AND OBJECTIVES: This study aimed to evaluate the diagnostic performance of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in differentiation of four spinal lesions by using heuristic and pharmacokinetic parameters analyzed from DCE signal intensity time course. MATERIALS AND METHODS: DCE-MRI of 62 subjects with confirmed myeloma (n = 9), metastatic cancer (n = 22), lymphoma (n = 7), and inflammatory tuberculosis (TB) (n = 24) in the spine were analyzed retrospectively...
February 2, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28154154/renal-cell-carcinoma-metastasis-involving-vertebral-hemangioma-dual-percutaneous-treatment-by-navigational-bipolar-radiofrequency-ablation-and-high-viscosity-cement-vertebroplasty
#6
Jean-Baptiste Zerlauth, Reto Meuli, Vincent Dunet
The case of a 70-year-old woman with progressive renal cell carcinoma (RCC) metastatic invasion of a L3 vertebral hemangioma treated by dual percutaneous radiofrequency ablation (RFA) and vertebroplasty is reported. The patient was surgically treated for RCC in 2001. Chemotherapy and immunotherapy were introduced in 2013 for ovarian, bladder and cerebral metastatic disease. An asymptomatic L3 benign hemangioma was noticed at this time. One-year CT and MRI follow-up studies demonstrated a nodular isolated soft tissue lesion involving the anterior edge of the hemangioma...
February 2, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28143487/helical-tomotherapy-of-spinal-chordomas-french-multicentric-retrospective-study-of-a-cohort-of-30-cases
#7
Maxime Bobin, Christina Zacharatou, Paul Sargos, Véronique Brouste, Albert Lisbona, Marc-André Mahé, Georges Noël, Amandine Halley, Loïc Feuvret, Louis Gras, Stéphanie Hoppe, Bénédicte Henriques de Figueiredo, Guy Kantor
PURPOSE: To evaluate the efficacy and toxicity of helical tomotherapy (HT) in the management of spine chordomas when proton therapy is unavailable or non-feasible. METHODS AND MATERIALS: Between 2007 and 2013, 30 patients with biopsy-proven chordomas were treated by HT in five French institutions. Information regarding local control (LC), overall survival (OS), progression-free survival (PFS) and metastasis-free survival (MFS) was collected. Clinical efficacy, toxicity and treatment quality were evaluated...
January 31, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28120768/-use-of-pedicle-percutaneous-cemented-screws-in-the-management-of-patients-with-poor-bone-stock
#8
S Pesenti, T Graillon, N Mansouri, T Adetchessi, P Tropiano, B Blondel, S Fuentes
INTRODUCTION: Management of patients with poor bone stock remains difficult due to the risks of mechanical complications such as screws pullouts. At the same time, development of minimal invasive spinal techniques using a percutaneous approach is greatly adapted to these fragile patients with a reduction in operative time and complications. The aim of this study was to report our experience with cemented percutaneous screws in the management of patients with a poor bone stock. METHODS: Thirty-five patients were included in this retrospective study...
December 2016: Neuro-Chirurgie
https://www.readbyqxmd.com/read/28110361/the-impact-of-routine-whole-spine-mri-screening-in-the-evaluation-of-spinal-degenerative-diseases
#9
Rishi Mugesh Kanna, Younis Kamal, Anupama Mahesh, Prakash Venugopal, Ajoy Prasad Shetty, S Rajasekaran
PURPOSE: Magnetic resonance imaging (MRI) of the spine is a sensitive investigation, which not only provides detailed images of the spinal column but also adjacent spinal regions and para-vertebral organ systems. Such incidental findings (IF) can be asymptomatic but significant. The efficacy of whole spine T2 sagittal screening in providing additional information has been demonstrated in several spinal diseases but its routine use in patients with spinal degenerative diseases has not been studied...
January 21, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28110254/leptomeningeal-carcinomatosis-in-non-small-cell-lung-cancer-patients-a-continuing-challenge-in-the-personalized-treatment-era
#10
REVIEW
J Remon, E Le Rhun, B Besse
Leptomeningeal metastasis is a fatal manifestation seen in advanced cancer patients. Its incidence is increasing, reaching 3.8% in molecularly unselected non-small cell lung cancer patients and up to 5% and 9% in ALK-rearranged and EGFR-mutant lung cancer patients, respectively. The prognosis remains poor despite systemic treatment, intrathecal chemotherapy, radiation therapy and personalized treatments in molecularly selected patients. However, new therapies with improved cerebral-spinal fluid penetration have been developed for subgroups of molecular selected patients indicating they could be promising therapeutic options for managing leptomeningeal disease...
February 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28110186/numb-chin-syndrome-as-a-sign-of-mandibular-metastasis-a-case-report
#11
Thomas Aerden, Koenraad Grisar, Patrick Neven, Esther Hauben, Constantinus Politis
INTRODUCTION: Metastasis to the oral cavity can be located in both the soft and bony tissues and comprise only 1% of all oral malignancies; however, it is clinically significant because it indicates widespread metastatic disease and an unfavorable prognosis. A numb chin is an important presentation of oral metastasis, but other dental and systemic pathology may be involved. PRESENTATION OF CASE: We present the case of a 54-year-old woman who presented with numb chin syndrome 8 years after a diagnosis of primary breast carcinoma...
January 4, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28108084/cholangiocarcinoma-with-spinal-metastasis-single-center-survival-analysis
#12
Pawalee Dowsiriroj, Permsak Paholpak, Winai Sirichativapee, Taweechok Wisanuyotin, Pat Laupattarakasem, Kamolsak Sukhonthamarn, Weerachai Kosuwon, Polasak Jeeravipoolvarn
The aim of this study was to perform a survival analysis of Cholangiocarcinoma (CCA) with spinal metastases. 55 cases of CCA with spinal metastases were retrospectively reviewed. We recorded age, sex, Kanofsky performance score, Frankel scale, number and region of affected vertebrae, presence of appendicular bone metastases, treatment received, and survival time; then performed a survival analysis. Overall median survival was 4months (95%CI, 2.89-5.11). Frankel A had the poorest survival (2months-95%CI, 1.15-2...
January 17, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28087968/thymic-carcinoma-presenting-with-an-unusual-and-delayed-metastasis-to-the-neural-foramen-mimicking-thoracic-spinal-radiculopathy
#13
H M Low, C F Wong, M W H'ng
We report a case of metastatic thymic carcinoma which presented as an enhancing mass located in the neural foramen of the thoracic spine. More common tumours which arise in the neural foramen would include a neurogenic tumour or developmental anomalies such as a foregut duplication cyst. This case is singular firstly because the lesion present as radiculopathy which mimics a neurogenic tumour. Secondly, the presentation was unusually delayed as the patient presented to our centre more than a decade after the resection of the primary tumour in another institution...
December 2016: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28057095/-comparison-of-curative-effect-and-prognosis-analysis-of-patients-with-spinal-metastases-treated-by-percutaneous-vertebroplasty-combined-with-postoperative-radiotherapy-and-radiotherapy-alone
#14
X Y Cao, Y S Liu, M X Lei, S B Liu, S G Zhou, Y C Cao, W G Jiang
Objective: To evaluate the efficacy of percutaneous vertebroplasty(PVP) combined with postoperative radiotherapy and radiotherapy alone in the treatment of spinal metastatic tumors and to evaluate the prognostic factors for survival. Methods: From December 2011 to December 2015, according to the choice of treatment, patients in group A(60 cases) were treated with PVP combined with postoperative radiotherapy and those in group B(50 cases) underwent radiotherapy alone, age, sex, primary tumor type , and other basic characteristics were analyzed in both groups in department of orthopedics and radiotherapy department, 307 Hospital of the People's Liberation Army...
December 20, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28055232/biological-features-of-a-renal-cell-carcinoma-cell-line-derived-from-spinal-metastasis
#15
Zhenhua Zhou, Yan Li, Huiqing Wang, Xudong Wang, Jianru Xiao
The establishment of a metastatic renal cell carcinoma (mRCC) cell line can facilitate the search for molecular mechanisms involved in RCC metastasis. A novel human mRCC cell line, designated RCC96, was established from an mRCC of the spine from a 65-year-old Chinese man. Morphology, cell cycle phase, chromosome number, cell capability of migration, tumorigenicity in nude mice, and cytogenetic features of RCC96 were investigated. Cell growth curve was detected and the cell number doubling time was 52 h. Karyotype analysis showed that these cells were polyploidy...
February 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28049505/surgical-intervention-for-vertebral-metastases-may-benefit-lung-cancer-patients-no-less-than-other-patients-a-retrospective-study
#16
Takashi Kobayashi, Naohisa Miyakoshi, Toshiki Abe, Eiji Abe, Kazuma Kikuchi, Yoichi Shimada, Seiko Matsumoto, Shin Fukui
BACKGROUND: Spinal metastasis is considered to have a worse prognosis in lung cancer than in other cancers, but recent clinical studies report improved overall survival of lung cancer. We compared the postoperative prognoses of vertebral metastatic tumors from lung with other types of cancer. METHODS: From 2011 to 2015, 31 Japanese patients (mean age 73 years, range 55-88 years; 19 males, 12 females) underwent surgery for spinal metastasis at our center. We observed patients retrospectively in March 2016, dividing them into groups by cancer type: lung (LK group, n = 10); prostate, breast, or thyroid (PB group, n = 12); and other (OT group, n = 9)...
January 4, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28047211/su-f-t-512-a-dosimetric-comparison-for-palliative-spine-metastasis-treatments-3-d-vs-conformal-arc
#17
V Ulizio, M Taylor
PURPOSE: Spine metastases have traditionally been treated using a parallel opposed 3-D technique: an anterior field and a posterior field (AP/PA). This has proven to give the lesions adequate coverage. The downside to this type of treatment is that the full prescription dose covers a large area of the patient and can go through critical organs such as the heart, spine, lungs, bowel, and others depending on the vertebrae being treated. Conformal arc therapy can also be used for this type of treatment...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28044212/skeletal-related-events-and-prognosis-in-urothelial-cancer-patients-with-bone-metastasis
#18
Yusuke Tsuda, Tohru Nakagawa, Yusuke Shinoda, Atsushi Kanatani, Taketo Kawai, Satoru Taguchi, Yukio Yamada, Ryoko Sawada, Haruki Kume, Yukio Homma, Sakae Tanaka, Hirotaka Kawano
BACKGROUND: The aim of the present study was to elucidate the details of bone metastasis (BM) and the resulting skeletal-related events (SREs), and survival and prognostic factors, in urothelial cancer (UC) patients with BM. METHODS: A total of 48 UC patients with BM who were treated at our institution between 1994 and 2013 were enrolled. Details of BM and SREs were investigated. The Kaplan-Meier method was used to estimate survival duration. Relationships between several clinical features and survival were analyzed using the log-rank test and the Cox hazard model...
January 2, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28041319/rapid-and-complete-radiological-resolution-of-an-intradural-cervical-cord-lung-cancer-metastasis-treated-with-spinal-stereotactic-radiosurgery-case-report
#19
E Emily Bennett, Camille Berriochoa, Ghaith Habboub, Scott Brigeman, Samuel T Chao, Lilyana Angelov
Stereotactic radiosurgery (SRS) has emerged as a treatment option for patients with spinal metastatic disease. Although SRS has been shown to be successful in a multitude of extradural metastatic tumors causing cord compression, very few cases of intradural treatment have been reported. The authors present a rare case of an intradural extramedullary metastatic small cell lung cancer lesion to the cervical spine resulting in cord compression in an area that had also been extensively pretreated with conventional external-beam radiation therapy...
January 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28034746/new-imaging-characteristics-for-predicting-postoperative-neurological-status-in-patients-with-metastatic-epidural-spinal-cord-compression-a-retrospective-analysis-of-81-cases
#20
Mingxing Lei, Shubin Liu, Shaoxing Yang, Yaosheng Liu, Cheng Wang, Hongjun Gao
BACKGROUND CONTEXT: Several clinical features have been proposed for prediction of postoperative functional outcome in patients with metastatic epidural spinal cord compression (MESCC). However, few articles address the relationship between preoperative imaging characteristics and the postoperative neurological status. PURPOSE: This study aims to analyze the postoperative functional outcome and identify new imaging parameters for predicting postoperative neurological status in patients with MESCC...
December 26, 2016: Spine Journal: Official Journal of the North American Spine Society
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