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Pain AND brain changes

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https://www.readbyqxmd.com/read/28731567/integration-of-white-matter-network-is-associated-with-interindividual-differences-in-psychologically-mediated-placebo-response-in-migraine-patients
#1
Jixin Liu, Shaohui Ma, Junya Mu, Tao Chen, Qing Xu, Wanghuan Dun, Jie Tian, Ming Zhang
Individual differences of brain changes of neural communication and integration in the modular architecture of the human brain network exist for the repeated migraine attack and physical or psychological stressors. However, whether the interindividual variability in the migraine brain connectome predicts placebo response to placebo treatment is still unclear. Using DTI and graph theory approaches, we systematically investigated the topological organization of white matter networks in 71 patients with migraine without aura (MO) and 50 matched healthy controls at three levels: global network measure, nodal efficiency, and nodal intramodule/intermodule efficiency...
July 21, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28729077/white-matter-microstructure-degenerates-in-patients-with-postherpetic-neuralgia
#2
Fuxiang Chen, Fuyong Chen, Zhanfang Shang, Yuan Shui, Guorong Wu, Chen Liu, Zhangya Lin, Yuanxiang Lin, Lianghong Yu, Dezhi Kang, Wei Tao, Yongjie Li
OBJECTIVE: The central mechanisms underlying postherpetic neuralgia (PHN) pain remain unknown. The primary purpose of this study was to identify microstructural white matter changes closely related to the PHN pain by means of diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS) analysis. METHODS: DTI data of the brains were obtained from 8 PHN patients and 8 healthy controls (HC) that were matched in age, gender, and educational level. DTI metrics, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD), were separately compared between the two groups using TBSS analysis to detect subtle microstructural changes...
July 17, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28727713/local-brain-activity-differences-between-herpes-zoster-and-postherpetic-neuralgia-patients-a-resting-state-functional-mri-study
#3
Song Cao, Ying Li, Wenwen Deng, Bangyong Qin, Yi Zhang, Peng Xie, Jie Yuan, Buwei Yu, Tian Yu
BACKGROUND: Herpes zoster (HZ) can develop into postherpetic neuralgia (PHN), both of which are painful diseases. PHN patients suffer chronic pain and emotional disorders. Previous studies showed that the PHN brain displayed abnormal activity and structural change, but the difference in brain activity between HZ and PHN is still not known. OBJECTIVES: To identify regional brain activity changes in HZ and PHN brains with resting-state functional magnetic resonance imaging (rs-fMRI) technique, and to observe the differences between HZ and PHN patients...
July 2017: Pain Physician
https://www.readbyqxmd.com/read/28727225/intact-blood-brain-barrier-during-spontaneous-attacks-of-migraine-without-aura-a-3t-dce-mri-study
#4
F M Amin, A Hougaard, S P Cramer, C E Christensen, F Wolfram, H B W Larsson, M Ashina
BACKGROUND AND PURPOSE: The integrity of the blood-brain barrier (BBB) has been questioned in migraine, but BBB permeability has never been investigated during spontaneous migraine attacks. In the present study, BBB permeability during spontaneous attacks of migraine without aura was investigated compared to an interictal state. METHODS: Seventy-four patients suffering from migraine without aura were recruited to participate in this cross-sectional dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) study...
July 20, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28725706/the-effect-of-deep-brain-stimulation-on-the-non-motor-symptoms-of-parkinson-s-disease-a-critical-review-of-the-current-evidence
#5
REVIEW
Mónica M Kurtis, Thadshani Rajah, Luisa F Delgado, Haidar S Dafsari
The benefit of deep brain stimulation (DBS) in controlling the motor symptoms of Parkinson's disease is well established, however, the impact on the non-motor symptoms (NMS) remains to be elucidated, although the growing investigative efforts are promising. This article reviews the reported data and considers the level of evidence available with regard to the effect of DBS on NMS total burden and on the cognitive, neuropsychiatric, sleep, pain, dysautonomic, and weight domains. Multiple case series suggest that DBS improves the burden of NMS by reducing prevalence, intensity, and non-motor fluctuations...
2017: NPJ Parkinson's Disease
https://www.readbyqxmd.com/read/28719509/the-relationship-between-structural-and-functional-brain-changes-and-altered-emotion-and-cognition-in-chronic-low-back-pain-a-systematic-review-of-mri-and-fmri-studies
#6
Sin Ki Ng, Donna M Urquhart, Paul B Fitzgerald, Flavia M Cicuttini, Sultana Monira Hussain, Bernadette M Fitzgibbon
OBJECTIVES: Chronic low back pain (CLBP) is a major health issue, yet its underlying mechanisms remain unknown. Studies have demonstrated the importance of emotion and cognition in chronic pain, however, the relevant brain physiology in magnetic resonance imaging (MRI) studies are unclear in CLBP populations. Therefore, this review aimed to identify MRI brain changes and examine their potential relationship with emotional and cognitive processes in CLBP. METHOD: A systematic search was conducted in 5 databases...
July 17, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28716266/sativex%C3%A2-effects-on-promoter-methylation-and-on-cnr1-cnr2-expression-in-peripheral-blood-mononuclear-cells-of-progressive-multiple-sclerosis-patients
#7
Massimo Santoro, Massimiliano Mirabella, Chiara De Fino, Assunta Bianco, Matteo Lucchini, Francesco Losavio, Andrea Sabino, Viviana Nociti
Multiple sclerosis (MS) is a chronic demyelinating central nervous system (CNS) disease that involve oligodendrocyte loss and failure to remyelinate damaged brain areas causing a progressive neurological disability. Studies in MS mouse model suggest that cannabinoids ameliorate symptoms as spasticity, tremor and pain reducing inflammation via cannabinoid-mediated system. The aim of our study is to investigate the changes in cannabinoid type 1 (CNR1) and 2 (CNR2) receptors mRNA expression levels and promoter methylation in peripheral blood mononuclear cells (PBMCs) of MS secondary progressive (MSS-SP) patients treated with Sativex®...
August 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28715355/repeated-exposure-to-sucrose-for-procedural-pain-in-mouse-pups-leads-to-long-term-widespread-brain-alterations
#8
Sophie Tremblay, Manon Ranger, Cecil M Y Chau, Jacob Ellegood, Jason P Lerch, Liisa Holsti, Daniel Goldowitz, Ruth E Grunau
Oral sucrose is administered routinely to reduce pain of minor procedures in premature infants and is recommended as standard care in international guidelines. No human or animal studies on effects of early repeated sucrose exposure on long-term brain development have been done in the context of pain. We evaluated the effects of repeated neonatal sucrose treatment before an intervention on long-term brain structure in mouse pups. Neonatal C57Bl/6J mice (n = 109) were randomly assigned to one of 2 treatments (vehicle vs sucrose) and one of 3 interventions (handling, touch, or needle-prick)...
August 2017: Pain
https://www.readbyqxmd.com/read/28708753/effectiveness-of-preoperative-intranasal-dexmedetomidine-compared-with-oral-midazolam-for-the-prevention-of-emergence-delirium-in-the-pediatric-patient-undergoing-general-anesthesia-a-systematic-review
#9
James FitzSimons, Laura S Bonanno, Stephanie Pierce, Jennifer Badeaux
BACKGROUND: Emergence delirium is defined as a cognitive disturbance during emergence from general anesthesia resulting in hallucinations, delusions and confusion manifested by agitation, restlessness, involuntary physical movement and extreme flailing in bed. Postoperative emergence delirium develops in 12% to 18% of all children undergoing general anesthesia for surgery. This post-anesthetic phenomenon changes cognitive and psychomotor behavior, and puts pediatric patients and health care personnel at risk of injury...
July 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28706741/the-link-between-depression-and-chronic-pain-neural-mechanisms-in-the-brain
#10
REVIEW
Jiyao Sheng, Shui Liu, Yicun Wang, Ranji Cui, Xuewen Zhang
Chronic pain, as a stress state, is one of the critical factors for determining depression, and their coexistence tends to further aggravate the severity of both disorders. Unfortunately, their association remains unclear, which creates a bottleneck problem for managing chronic pain-induced depression. In recent years, studies have found considerable overlaps between pain- and depression-induced neuroplasticity changes and neurobiological mechanism changes. Such overlaps are vital to facilitating the occurrence and development of chronic pain and chronic pain-induced depression...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28706449/effects-of-tianeptine-on-symptoms-of-fibromyalgia-via-bdnf-signaling-in-a-fibromyalgia-animal-model
#11
Hwayoung Lee, Jiyun Im, Hansol Won, Wooyoung Nam, Young Ock Kim, Sang Won Lee, Sanghyun Lee, Ik-Hyun Cho, Hyung-Ki Kim, Jun-Tack Kwon, Hak-Jae Kim
Previous reports have suggested that physical and psychological stresses may trigger fibromyalgia (FM). Stress is an important risk factor in the development of depression and memory impairments. Antidepressants have been used to prevent stress-induced abnormal pain sensation. Among various antidepressants, tianeptine has been reported to be able to prevent neurodegeneration due to chronic stress and reverse decreases in hippocampal volume. To assess the possible effect of tianeptine on FM symptoms, we constructed a FM animal model induced by restraint stress with intermittent cold stress...
July 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28701953/astrocyte-activation-in-locus-coeruleus-is-involved-in-neuropathic-pain-exacerbation-mediated-by-maternal-separation-and-social-isolation-stress
#12
Kazuo Nakamoto, Fuka Aizawa, Megumi Kinoshita, Yutaka Koyama, Shogo Tokuyama
Our previous studies demonstrated that emotional dysfunction associated with early life stress exacerbated nerve injury-induced mechanical allodynia. Sex differences were observed in several anxiety tests, but not in mechanical allodynia. To elucidate the mechanism underlying these findings, we have now investigated the involvement of astrocytes in emotional dysfunction and enhancement of nerve injury-induced mechanical allodynia in mice subjected to maternal separation combined with social isolation (MSSI) as an early life stress...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28700539/propranolol-treatment-prevents-chronic-central-sensitization-induced-by-repeated-dural-stimulation
#13
Nelly Boyer, Jérémy Signoret-Genest, Alain Artola, Radhouane Dallel, Lénaïc Monconduit
Migraine is currently conceptualized as a chronic disease with episodic manifestations. In some patients, migraine attack frequency increases, leading to chronic migraine. Daily preventive therapy is initiated to decrease attack frequency. Propranolol, a first-line medication for migraine prophylaxis, reduces attack frequency in nearly 50% of patients receiving it. However, the mechanisms of its antimigraine action are unclear. We examined the effect of daily propranolol treatment (10 mg.kg per os, 8 days) in a rat model of recurrent activation of dural nociceptors (repeated infusion of an inflammatory soup (IS) on the dura through a cannula every 2-3 days)...
July 8, 2017: Pain
https://www.readbyqxmd.com/read/28695690/cerebral-vasospasm-in-acute-porphyria
#14
P Olivier, D Van Melkebeke, P-J Honoré, L Defreyne, D Hemelsoet
BACKGROUND AND PURPOSE: Porphyrias are a group of inherited metabolic disorders resulting from a specific deficiency along the pathway of haem biosynthesis. A clinical classification distinguishes acute from non-acute porphyrias considering the occurrence of life-threatening neurovisceral attacks, presenting with abdominal pain, neuropsychiatric disturbance and neuropathy. Vasospasm is a very rare complication that can occur in all major types of acute porphyria. METHODS: We describe a porphyric crisis with vasospasm in a woman with previously undiagnosed acute porphyria...
July 10, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28695537/fos-protein-as-a-marker-of-neuronal-activity-a-useful-tool-in-the-study-of-the-mechanism-of-action-of-natural-products-with-analgesic-activity
#15
REVIEW
Priscila L Santos, Renan G Brito, João Pedro S C F Matos, Jullyana S S Quintans, Lucindo J Quintans-Júnior
Pain treatment is still ineffective in many conditions and remains one of the greatest challenges of modern medicine. Historically, due to the incredible variety of pharmacologically promising natural products (NPs) and the chemical complexity of their compounds, scientists have explored their use as a source of treatment for diseases or symptomatology. Fos protein and its precursor, the gene c-Fos, have been the subject of study in relation to the pathophysiology of pain as a possible tool to aid in its understanding...
July 10, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28692006/brain-signature-and-functional-impact-of-centralized-pain-a-multidisciplinary-approach-to-the-study-of-chronic-pelvic-pain-mapp-network-study
#16
Jason J Kutch, Eric Ichesco, Johnson P Hampson, Jennifer S Labus, Melissa A Farmer, Katherine T Martucci, Timothy J Ness, Georg Deutsch, A Vania Apkarian, Sean C Mackey, David J Klumpp, Anthony J Schaeffer, Larissa V Rodriguez, Karl J Kreder, Dedra Buchwald, Gerald L Andriole, H Henry Lai, Chris Mullins, John W Kusek, J Richard Landis, Emeran A Mayer, J Quentin Clemens, Daniel J Clauw, Richard E Harris
Chronic pain is often measured with a severity score that overlooks its spatial distribution across the body. This widespread pain is thought to be a marker of centralization, a central nervous system process that decouples pain perception from nociceptive input. Here, we investigated whether centralization is manifested at the level of the brain using data from 1079 participants in the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network (MAPP) study. Participants with a clinical diagnosis of urological chronic pelvic pain syndrome (UCPPS) were compared to pain-free controls and fibromyalgia patients, the prototypical centralized pain disorder...
June 30, 2017: Pain
https://www.readbyqxmd.com/read/28690143/the-brain-penetrant-5-ht7-receptor-agonist-lp-211-reduces-the-sensory-and-affective-components-of-neuropathic-pain
#17
Mirko Santello, Alberto Bisco, Natalie Elisabeth Nevian, Enza Lacivita, Marcello Leopoldo, Thomas Nevian
Neuropathic pain is a debilitating pathological condition of high clinical relevance. Changes in neuronal excitability in the anterior cingulate cortex (ACC) play a central role in the negative emotional and affective aspects of chronic pain. We evaluated the effects of LP-211, a new serotonin-receptor-type-7 (5-HT7R) agonist that crosses the blood-brain barrier, on ACC neurons in a mouse model of neuropathic pain. LP-211 reduced synaptic integration in layer 5 pyramidal neurons, which was enhanced in neuropathic pain due to a dysfunction of dendritic hyperpolarization-activated-and-cyclic-nucleotide-regulated (HCN) channels...
July 6, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28689600/meditation-and-the-brain-neuronal-correlates-of-mindfulness-as-assessed-with-near-infrared-spectroscopy
#18
Friederike Gundel, Johanna von Spee, Sabrina Schneider, Florian B Haeussinger, Martin Hautzinger, Michael Erb, Andreas J Fallgatter, Ann-Christine Ehlis
Mindfulness meditation as a therapeutic intervention has been shown to have positive effects on psychological problems such as depression, pain or anxiety disorders. In this study, we used functional near-infrared spectroscopy (fNIRS) to detect differences in hemodynamic responses of meditation experts (14 participants) and a control group (16 participants) in a resting and a mindfulness condition. In both conditions, the sound of a meditation bowl was used to find group differences in the auditory system and adjacent cortical areas...
April 8, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28683024/brain-imaging-of-pain-sensitization-in-patients-with-knee-osteoarthritis
#19
Jesus Pujol, Gerard Martínez-Vilavella, Jone Llorente-Onaindia, Ben J Harrison, Marina López-Solà, Marina López-Ruiz, Laura Blanco-Hinojo, Pere Benito, Joan Deus, Jordi Monfort
A relevant aspect in osteoarthritic pain is neural sensitization. This phenomenon involves augmented responsiveness to painful stimulation and may entail a clinically worse prognosis. We used functional MRI (fMRI) to study pain sensitization in patients with knee osteoarthritis. Sixty patients were recruited and pain sensitization was clinically defined on the basis of regional spreading of pain (spreading sensitization) and increased pain response to repeated stimulation (temporal summation). fMRI testing involved assessing brain responses to both pressure and heat stimulation...
July 3, 2017: Pain
https://www.readbyqxmd.com/read/28680401/cannabidiol-is-a-potential-therapeutic-for-the-affective-motivational-dimension-of-incision-pain-in-rats
#20
Karina Genaro, Débora Fabris, Ana L F Arantes, Antônio W Zuardi, José A S Crippa, Wiliam A Prado
Background: Pain involves different brain regions and is critically determined by emotional processing. Among other areas, the rostral anterior cingulate cortex (rACC) is implicated in the processing of affective pain. Drugs that interfere with the endocannabinoid system are alternatives for the management of clinical pain. Cannabidiol (CBD), a phytocannabinoid found in Cannabis sativa, has been utilized in preclinical and clinical studies for the treatment of pain. Herein, we evaluate the effects of CBD, injected either systemically or locally into the rACC, on mechanical allodynia in a postoperative pain model and on the negative reinforcement produced by relief of spontaneous incision pain...
2017: Frontiers in Pharmacology
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