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Pain AND brain changes

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https://www.readbyqxmd.com/read/29042341/pain-self-management-for-veterans-development-and-pilot-test-of-a-stage-based-mobile-optimized-intervention
#1
Sara S Johnson, Deborah A Levesque, Lynne E Broderick, Dustin G Bailey, Robert D Kerns
BACKGROUND: Chronic pain is a significant public health burden affecting more Americans than cardiovascular disease, diabetes, and cancer combined. Veterans are disproportionately affected by chronic pain. Among previously deployed soldiers and veterans, the prevalence of chronic pain is estimated between 44% and 60%. OBJECTIVE: The objective of this research was to develop and pilot-test Health eRide: Your Journey to Managing Pain, a mobile pain self-management program for chronic musculoskeletal pain for veterans...
October 17, 2017: JMIR Medical Informatics
https://www.readbyqxmd.com/read/29038061/structural-and-functional-brain-changes-at-early-and-late-stages-of-complex-regional-pain-syndrome
#2
Mahsa Shokouhi, Collin Clarke, Patricia Morley-Forster, Dwight E Moulin, Karen Davis, Keith St Lawrence
Brain plasticity is demonstrated in complex regional pain syndrome (CRPS), although it is unclear how it modulates at different stages of CRPS. The observation that symptoms can progress over time suggests that the pattern of brain changes might also evolve. We measured structural and functional changes as well as sensorimotor integration at early and late stages (ES and LS) of CRPS. Twelve ES patients, sixteen LS patients, and sixteen age- and sex-matched controls were recruited. Gray matter (GM) volume was estimated using voxel-based morphometry...
October 13, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29033604/chronic-pain-and-adult-hippocampal-neurogenesis-translational-implications-from-preclinical-studies
#3
Mariagrazia Grilli
Adult hippocampal neurogenesis (ahNG) occurs in the human brain. Adult generated neurons have been proposed to functionally contribute to relevant hippocampal functions such as learning and memory, mood regulation, and stress response. Learning, environmental enrichment, and physical exercise exert positive effects on ahNG. In parallel, these proneurogenic stimuli have been shown to ameliorate cognitive performance and/or depressive-like behavior in animal models. Conversely, aging, social isolation, and chronic stress exert negative effects on ahNG...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29025157/chronic-pain-after-traumatic-brain-injury-pathophysiology-and-pain-mechanisms
#4
Karen-Amanda Irvine, J David Clark
Background: Traumatic brain injury refers to a broad range of neurological, cognitive, and emotional factors that result from the application of an external force to the head. Individuals recovering from traumatic brain injury will frequently experience acute and chronic pain. Objective: The objective of this paper is to discuss the pathophysiological changes resulting from traumatic brain injury and how these may be involved in the development and persistence of pain after injury...
August 29, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28979158/the-central-sensitization-inventory-validated-and-adapted-for-a-brazilian-population-psychometric-properties-and-its-relationship-with-brain-derived-neurotrophic-factor
#5
Wolnei Caumo, Luciana C Antunes, Jéssica Lorenzzi Elkfury, Evelyn G Herbstrith, Raquel Busanello Sipmann, Andressa Souza, Iraci Ls Torres, Vinicius Souza Dos Santos, Randy Neblett
OBJECTIVES: The primary aim was to assess the psychometric properties (including internal consistency, construct validity, reproducibility, and factor structure) of the Central Sensitization Inventory (CSI), adapted and validated for a Brazilian population (CSI-BP). Additionally, we evaluated the relationship between the CSI-BP and the serum brain-derived neurotrophic factor (BDNF) and determined if the symptoms elicited by the CSI-BP discriminate between subjects who do/do not respond to the conditioned pain modulation (CPM) task, as assessed by change in numeric pain scale (0-10) score...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28971481/transcranial-magnetic-stimulation-studies-in-complex-regional-pain-syndrome-type-i-a-review
#6
REVIEW
R Nardone, F Brigo, Y Höller, L Sebastianelli, V Versace, L Saltuari, P Lochner, E Trinka
The sensory and motor cortical representation corresponding to the affected limb is altered in patients with complex regional pain syndrome (CRPS). Transcranial magnetic stimulation (TMS) represents a useful non-invasive approach for studying cortical physiology. If delivered repetitively, TMS can also modulate cortical excitability and induce long-lasting neuroplastic changes. In this review, we performed a systematic search of all studies using TMS to explore cortical excitability/plasticity and repetitive TMS (rTMS) for the treatment of CRPS...
October 3, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28971229/role-of-the-guanine-nucleotide-binding-protein-g%C3%AE-o-in-the-development-of-morphine-tolerance-and-dependence
#7
Jennifer T Lamberts, Lisa D Rosenthal, Emily M Jutkiewicz, John R Traynor
RATIONALE: The use of morphine and other opioids for chronic pain is limited by the development of analgesic tolerance and physical dependence. Morphine produces its effects by activating the μ opioid receptor, which couples to Gαi/o-containing heterotrimeric G proteins. Evidence suggests that the antinociceptive effects of morphine are mediated by Gαo. However, the role of Gαo in the development of morphine tolerance and dependence is unknown. OBJECTIVE: The objective of the study is to evaluate the contribution of Gαo to the development of morphine tolerance and dependence in mice...
October 3, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28970017/role-of-ventrolateral-orbital-cortex-muscarinic-and-nicotinic-receptors-in-modulation-of-capsaicin-induced-orofacial-pain-related-behaviors-in-rats
#8
Esmaeal Tamaddonfard, Amir Erfanparast, Amir Abbas Farshid, Fatmeh Delkhosh-Kasmaie
Acetylcholine, as a major neurotransmitter, mediates many brain functions such as pain. This study was aimed to investigate the effects of microinjection of muscarinic and nicotinic acetylcholine receptor antagonists and agonists into the ventrolateral orbital cortex (VLOC) on capsaicin-induced orofacial nociception and subsequent hyperalgesia. The right side of VLOC was surgically implanted with a guide cannula in anaesthetized rats. Orofacial pain-related behaviors were induced by subcutaneous injection of a capsaicin solution (1...
September 29, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28967357/in-the-spine-or-in-the-brain-recent-advances-in-pain-neuroscience-applied-in-the-intervention-for-low-back-pain
#9
REVIEW
Jo Nijs, Jacqui Clark, Anneleen Malfliet, Kelly Ickmans, Lennard Voogt, Sanneke Don, Hester den Bandt, Dorien Goubert, Jeroen Kregel, Iris Coppieters, Wim Dankaerts
Conservative, surgical and pharmacological strategies for chronic low back pain (CLBP) management offer at best modest effect sizes in reducing pain and related disability, indicating a need for improvement. Such improvement may be derived from applying contemporary pain neuroscience to the management of CLBP. Current interventions for people with CLBP are often based entirely on a "biomedical" or "psychological" model without consideration of information concerning underlying pain mechanisms and contemporary pain neuroscience...
September 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28965838/assessment-of-intra-and-inter-regional-interrelations-between-gaba-glx-and-bold-during-pain-perception-in-the-human-brain-a-combined-1-h-fmrs-and-fmri-study
#10
Marianne Cleve, Alexander Gussew, Gerd Wagner, Karl-Jürgen Bär, Jürgen R Reichenbach
To explore brain activity and the related neurochemical processes, current research focuses increasingly on the combined acquisition of (1)H MR spectra and fMRI data to investigate potential associations between local metabolite resting-state levels and stimulus-induced BOLD signal changes. In this study, whole-brain fMRI measurements and localized functional (1)H MEGA-PRESS MRS scans were conducted at 3T in healthy subjects prior to and during acute pain stimulation to quantify resting-state GABA+/tCr and Glx/tCr levels in the insular cortex together with their stimulus-induced changes and to explore associations between these neurochemical parameters with intra-regional but also inter-regional BOLD responses...
September 28, 2017: Neuroscience
https://www.readbyqxmd.com/read/28962922/treadmill-exercise-alleviated-prenatal-buprenorphine-exposure-induced-depression-in-rats
#11
Chih-Cheng Wu, Chih-Jen Hung, Shih-Yi Lin, Ya-Yu Wang, Cheng-Yi Chang, Wen-Ying Chen, Su-Lan Liao, Shue-Ling Raung, Ching-Ping Yang, Chun-Jung Chen
Mounting evidence suggests that physical exercise shows health benefits in a range of diseases, including psychiatric disorders. Perinatal opioid exposure produces neurobehavioral abnormality, which includes depression symptoms, in patients and their offspring following chronic use of buprenorphine, a mixed agonist/antagonist with a high affinity to opioid receptors, for pain control. Previously, we demonstrated that prenatal buprenorphine exposure in pregnant Sprague-Dawley rats starting from gestation day 7 and lasting for 14 days caused the development of depression-like phenotypes in pups at postnatal day 21...
September 27, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28955200/cingulate-alpha-2a-adrenoceptors-mediate-the-effects-of-clonidine-on-spontaneous-pain-induced-by-peripheral-nerve-injury
#12
Yong-Jie Wang, Zhen-Xing Zuo, Cheng Wu, Li Liu, Zhi-Hui Feng, Xiang-Yao Li
The anterior cingulate cortex (ACC) is an important brain area for the regulation of neuropathic pain. The α2A adrenoceptor is a good target for pain management. However, the role of cingulate α2A adrenoceptors in the regulation of neuropathic pain has been less studied. In this study, we investigated the involvement of cingulate α2A adrenoceptors in the regulation of neuropathic pain at different time points after peripheral nerve injury in mice. The application of clonidine, either systemically (0.5 mg/kg intraperitoneally) or specifically to the ACC, increased paw withdrawal thresholds (PWTs) and induced conditioned place preference (CPP) at day 7 after nerve injury, suggesting that cingulate α2 adrenoceptors are involved in the regulation of pain-like behaviors...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28954896/low-threshold-mechanoreceptors-play-a-frequency-dependent-dual-role-in-subjective-ratings-of-mechanical-allodynia
#13
Line Sofie Loken, Eugene Duff, Irene Tracey
In the setting of injury, myelinated primary afferent fibers that normally signal light touch, are thought to switch modality and instead signal pain. In the absence of injury, touch is perceived as more intense when firing rates of Aβ afferents increase. However, it is not known if varying the firing rates of Aβ afferents have any consequence to perception of dynamic mechanical allodynia (DMA). We hypothesized that, in the setting of injury, the unpleasantness of DMA would be intensified as the firing rates of Aβ afferents increase...
September 27, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28953832/biofeedback-and-neurofeedback-application-in-the-treatment-of-migraine
#14
Sanja Martic-Biocina, Ivana Zivoder, Goran Kozina
INTRODUCTION: Biofeedback is a non-invasive method of measurement of physiological functions. Precise instruments measure the slightest changes of different body functions-which are then in a clear and understandable manner shown in the form of feedback. Person gets an insight into what is going on inside the body and thus learns to change the patterns of behavior to improve health and performance. Any changes that are wanted are rewarded, which leads to learning of the new patterns of behavior...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28950826/long-term-effects-of-early-exposure-to-stress-pain-opioids-and-anaesthetics-on-pain-sensitivity-and-neurocognition
#15
Gerbrich E van den Bosch, Monique van Dijk, Dick Tibboel, Jurgen C de Graaff
Background Experimental studies have shown that neonatal exposure to stress, pain, opioids and anaesthetics may cause histologic and morphologic changes in the central nervous system with associated functional and behavioural changes in the long term. An important question is whether this holds true for humans also - and in particular for sick neonates who often are exposed to pain and receive anaesthetics and sedatives. Methods In this narrative review, we evaluate the effects of neonatal exposure to stress, pain, opioids and anaesthetics in infancy and childhood in animals and in preterm born and term born humans on pain sensitivity, brain morphology, cognition and behaviour later in life...
September 26, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28947182/pain-aging-and-dementia-towards-a-biopsychosocial-model
#16
REVIEW
Lucia Gagliese, Lynn R Gauthier, Nadine Narain, Tamlyn Freedman
Dementia is a progressive disease associated with irreversible impairment and loss of cognitive abilities. About half of older people with dementia experience pain. In this paper, we propose that pain in older people with dementia can be conceptualized as the final result of the interaction of three heterogeneous phenomena, pain, aging, and dementia, which are created and influenced by the interactions of predisposing, lifelong, and current biopsychosocial factors. We review pain assessment in people with dementia using both self-report and observational/behavioral measures...
September 22, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28936910/modulation-of-the-gut-microbiota-a-focus-on-treatments-for-irritable-bowel-syndrome
#17
Lucinda A Harris, Noemi Baffy
Irritable bowel syndrome (IBS), which is characterized by recurrent abdominal pain and disordered bowel habits, is one of the most common functional bowel disorders. IBS is a substantial burden on both patient health-related quality of life and health care costs. Several pathophysiologic mechanisms have been postulated for the occurrence of IBS, including altered gastrointestinal motility, visceral hypersensitivity, changes in gut permeability, immune activation, gut-brain dysregulation, autonomic nervous system dysfunction, and changes in the gut microbiota...
September 22, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28931334/repeated-exposure-to-experimental-pain-differentiates-combat-tbi-with-and-without-ptsd
#18
Irina A Strigo, Andrea D Spadoni, Sabra S Inslicht, Alan N Simmons
Mild traumatic brain injury(mTBI) and posttraumatic stress disorder(PTSD) are highly comorbid conditions that often co-occur with chronic pain. We have shown that women with PTSD following intimate partner violence show attenuated brain response to repeated experimental pain that was related to symptoms of avoidance. The aim of this study was to extend our prior findings to males with combat trauma and to examine brain response to experimental pain in men with and without PTSD who sustained mTBI during combat...
September 20, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28930716/antinociceptive-effect-of-ghrelin-in-a-rat-model-of-irritable-bowel-syndrome-involves-trpv1-opioid-systems
#19
Yuqing Mao, Zhengyang Li, Kan Chen, Huafang Yu, Shaoren Zhang, Miao Jiang, Yuanhua Ma, Chunli Liang, Hongyan Liu, Huanqing Li, Qian Hua, Hao Zhou, Yonghong Sun, Xiaoming Fan
BACKGROUND/AIMS: Irritable bowel syndrome (IBS), defined as recurrent abdominal pain and changes in bowel habits, seriously affects quality of life and ability to work. Ghrelin is a brain-gut hormone, which has been reported to show antinociceptive effects in peripheral pain. We investigated the effect of ghrelin on visceral hypersensitivity and pain in a rat model of IBS. METHODS: Maternal deprivation (MD) was used to provide a stress-induced model of IBS in Wistar rats...
September 20, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28928988/the-effect-of-glucocorticoid-and-glucocorticoid-receptor-interactions-on-brain-spinal-cord-and-glial-cell-plasticity
#20
REVIEW
Kathryn M Madalena, Jessica K Lerch
Stress, injury, and disease trigger glucocorticoid (GC) elevation. Elevated GCs bind to the ubiquitously expressed glucocorticoid receptor (GR). While GRs are in every cell in the nervous system, the expression level varies, suggesting that diverse cell types react differently to GR activation. Stress/GCs induce structural plasticity in neurons, Schwann cells, microglia, oligodendrocytes, and astrocytes as well as affect neurotransmission by changing the release and reuptake of glutamate. While general nervous system plasticity is essential for adaptation and learning and memory, stress-induced plasticity is often maladaptive and contributes to neuropsychiatric disorders and neuropathic pain...
2017: Neural Plasticity
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