keyword
https://read.qxmd.com/read/38528477/frequency-and-predictors-of-headache-in-the-first-12-months-after-traumatic-brain-injury-results-from-center-tbi
#1
JOURNAL ARTICLE
Emilie Isager Howe, Nada Andelic, Cathrine Brunborg, Marina Zeldovich, Eirik Helseth, Toril Skandsen, Alexander Olsen, Silje C R Fure, Alice Theadom, Katrin Rauen, Benedikte Å Madsen, Bram Jacobs, Joukje van der Naalt, Maria Carmela Tartaglia, Cathrine Elisabeth Einarsen, Gøril Storvig, Erling Tronvik, Cathrine Tverdal, Nicole von Steinbüchel, Cecilie Røe, Torgeir Hellstrøm
BACKGROUND: Headache is a prevalent and debilitating symptom following traumatic brain injury (TBI). Large-scale, prospective cohort studies are needed to establish long-term headache prevalence and associated factors after TBI. This study aimed to assess the frequency and severity of headache after TBI and determine whether sociodemographic factors, injury severity characteristics, and pre- and post-injury comorbidities predicted changes in headache frequency and severity during the first 12 months after injury...
March 25, 2024: Journal of Headache and Pain
https://read.qxmd.com/read/38522767/pain-relief-related-structural-brain-alterations-in-trigeminal-neuralgia-induced-by-non-invasive-stereotactic-radiosurgery-a-pilot-study
#2
JOURNAL ARTICLE
Jonas Kolodziej, Bogdan Pintea, Jan Patrick Boström, Burkhard Pleger
PURPOSE: Trigeminal neuralgia (TN) is a devastating chronic pain disorder, defined by unilateral shock like pain in at least one division of the trigeminal nerve. Although several studies have investigated structural brain plasticity in TN patients, treatment-induced alterations remain largely uninvestigated. MATERIALS/METHODS: Combining T1-weighted magnetic resonance imaging (MRI) with voxel-based morphometry (VBM) and multiple-regression analyses, we assessed gray matter maps of TN patients to investigate changes in gray matter volume (GMV) from before to half a year after stereotactic radiosurgery (SRS)...
March 22, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38518924/repetitive-transcranial-magnetic-stimulation-combined-with-sling-exercise-modulates-the-motor-cortex-in-patients-with-chronic-low-back-pain
#3
JOURNAL ARTICLE
Xin Li, Songwei Lu, Le Ge, Zhicheng Li, Rong Chen, Yao Zu, Ruochen Fu, Le Li, Chuhuai Wang
The study aims to explore the effects of combining repetitive transcranial magnetic stimulation (rTMS) with sling exercise (SE) intervention in patients with chronic low back pain (CLBP). This approach aims to directly stimulate brain circuits and indirectly activate trunk muscles to influence motor cortex plasticity. However, the impact of this combined intervention on motor cortex organization and clinical symptom improvement is still unclear, as well as whether it is more effective than either intervention alone...
March 20, 2024: Neuroscience
https://read.qxmd.com/read/38516317/functional-contribution-of-the-intestinal-microbiome-in-autism-spectrum-disorder-attention-deficit-hyperactivity-disorder-and-rett-syndrome-a-systematic-review-of-pediatric-and-adult-studies
#4
Valentina Caputi, Lee Hill, Melanie Figueiredo, Jelena Popov, Emily Hartung, Kara Gross Margolis, Kanish Baskaran, Papiha Joharapurkar, Michal Moshkovich, Nikhil Pai
INTRODUCTION: Critical phases of neurodevelopment and gut microbiota diversification occur in early life and both processes are impacted by genetic and environmental factors. Recent studies have shown the presence of gut microbiota alterations in neurodevelopmental disorders. Here we performed a systematic review of alterations of the intestinal microbiota composition and function in pediatric and adult patients affected by autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and Rett syndrome (RETT)...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38516315/research-on-the-multidimensional-brain-remodeling-mechanisms-at-the-level-of-brain-regions-circuits-and-networks-in-patients-with-chronic-lower-back-pain-caused-by-lumbar-disk-herniation
#5
JOURNAL ARTICLE
Yuan-Dong Mei, Hang Gao, Wei-Fei Chen, Wei Zhu, Chen Gu, Jun-Peng Zhang, Ji-Ming Tao, Xu-Yun Hua
INTRODUCTION: Chronic lower back pain (cLBP), frequently attributed to lumbar disk herniation (LDH), imposes substantial limitations on daily activities. Despite its prevalence, the neural mechanisms underlying lower back pain remain incompletely elucidated. Functional magnetic resonance imaging (fMRI) emerges as a non-invasive modality extensively employed for investigating neuroplastic changes in neuroscience. In this study, task-based and resting-state fMRI methodologies are employed to probe the central mechanisms of lower back pain...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38512737/mri-compatible-lumbopelvic-movement-measurement-system-to-validate-and-capture-task-performance-during-neuroimaging
#6
JOURNAL ARTICLE
Ahyoung Song, Kerrigan Sunday, Sheri P Silfies, Jennifer Mc Vendemia
Research suggests that structural and functional changes within the brain are associated with chronic low back pain, and these cortical alterations might contribute to impaired sensorimotor control of the trunk and hips in this population. However, linking sensorimotor brain changes with altered movement of the trunk and hips during task-based neuroimaging presents significant challenges. An MRI-safe pressure measurement system was developed to ensure proper task completion during neuroimaging by capturing movement patterns of the trunk (sensors under the lower back) and hips (sensors embedded in the foam roll under the knees)...
March 21, 2024: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://read.qxmd.com/read/38511229/focal-changes-in-alpha-oscillations-during-short-term-memorization-of-pain-a-high-density-electroencephalogram-study-with-source-localization
#7
JOURNAL ARTICLE
Argitxu Caldichoury, Luis Garcia-Larrea, Maud Frot
Memories of painful events constitute the basis for assessing patients' pain. This study explores the brain oscillatory activity during short-term memorization of a nociceptive stimulus. High-density EEG activity (128 electrodes) was recorded in 13 healthy subjects during a match-to-sample sensory discrimination task, whereby participants compared the intensity of a thumb-located electric shock (S2) with a prior stimulus to the same location (S1) delivered 8-10 s earlier. Stimuli were above or below the individual nociceptive threshold...
March 21, 2024: European Journal of Neuroscience
https://read.qxmd.com/read/38507912/hyperbaric-oxygen-for-the-treatment-of-carbon-monoxide-induced-delayed-neurological-sequelae-a-case-report-and-review-of-the-literature
#8
REVIEW
Zebedee Kr Wong, Colin Ka Teo, James Wm Kwek, Soo Joang Kim, Hooi Geok See
INTRODUCTION: Hyperbaric oxygen treatment (HBOT) remains a recognised treatment for acute carbon monoxide (CO) poisoning, but the utility of HBOT in treating CO-induced delayed neurological sequelae (DNS) is not yet established. CASE DESCRIPTION: A 26-year old woman presented with reduced consciousness secondary to CO exposure from burning charcoal. She underwent a single session of HBOT with US Navy Treatment Table 5 within six hours of presentation, with full neurological recovery...
March 31, 2024: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://read.qxmd.com/read/38501615/assessment-of-rat-brain-morphofunctional-state-in-a-parkinson-s-model-influence-of-therapeutic-agents-of-animal-and-synthetic-origins
#9
JOURNAL ARTICLE
M Danielyan, K Nebogova, Z Avetisyan, V Khachatryan, J Sarkissian, M Poghosyan, K Karapetyan
In neurodegenerative diseases, particularly in Parkinson's disease (PD), antinociceptive centers are often implicated in neurodegeneration, leading to persistent pain unresponsive to narcotic substances. This study investigated the periaqueductal gray matter (PAG) and the nucleus raphe magnus (NRM), components of the brain's antinociceptive system. In conditions of rotenone intoxication (an experimental PD model), morphological changes in intracellular structures were observed in PAG and NRM neurons, indicating metabolic disorders characteristic of PD (alterations in the shape and size of neuronal bodies and processes, disruption of acid phosphatase activity in neuron cytoplasm)...
January 2024: Georgian Medical News
https://read.qxmd.com/read/38500069/altered-trends-of-local-brain-function-in-classical-trigeminal-neuralgia-patients-after-a-single-trigger-pain
#10
JOURNAL ARTICLE
Juncheng Yan, Luoyu Wang, Lei Pan, Haiqi Ye, Xiaofen Zhu, Qi Feng, Haibin Wang, Zhongxiang Ding, Xiuhong Ge
OBJECTIVE: To investigate the altered trends of regional homogeneity (ReHo) based on time and frequency, and clarify the time-frequency characteristics of ReHo in 48 classical trigeminal neuralgia (CTN) patients after a single pain stimulate. METHODS: All patients underwent three times resting-state functional MRI (before stimulation (baseline), after stimulation within 5 s (triggering-5 s), and in the 30th min of stimulation (triggering-30 min))...
March 18, 2024: BMC Medical Imaging
https://read.qxmd.com/read/38500033/positive-effects-of-low-dose-s-ketamine-on-preventing-myocardial-injury-after-thoracoscopic-lobectomy-in-patients-aged-70-to-85
#11
JOURNAL ARTICLE
Ziqiang Bi, Lijuan Kong, Jiahui Zhao, Dongdong Song, Fengmei Duan
OBJECTIVE: To investigate the effects of low-dose S-ketamine on marker of myocardial injury (BNP, hs-cTnT and HFABP) after thoracoscopic lobectomy in patients aged 70 to 85. METHODS: One hundred patients (four cases excluded) aged 70-85 years, with body mass index 18-24 kg·m-2 and American Society of Anesthesiologists physical status II-III, scheduled for elective lobectomy from April 2022 to April 2023, were selected. The patients were divided into two groups by a random number table method, namely, the low-dose S-ketamine combined with GDFT group (group S) and the control group (group C), with 48 cases in each group...
March 19, 2024: BMC Anesthesiology
https://read.qxmd.com/read/38499209/infraorbital-nerve-injury-triggers-sex-specific-neuroimmune-responses-in-the-peripheral-trigeminal-pathway-and-common-pain-behaviours
#12
JOURNAL ARTICLE
James W M Kang, Olivia I Davanzo, Gaelle M Emvalomenos, Richelle Mychasiuk, Luke A Henderson, Kevin A Keay
Trigeminal neuropathic pain is emotionally distressing and disabling. It presents with allodynia, hyperalgesia and dysaesthesia. In preclinical models it has been assumed that cephalic nerve constriction injury shows identical molecular, cellular, and sex dependent neuroimmune changes as observed in extra-cephalic injury models. This study sought empirical evidence for such assumptions using the infraorbital nerve chronic constriction model (ION-CCI). We compared the behavioural consequences of nerve constriction with: (i) the temporal patterns of recruitment of macrophages and T-lymphocytes at the site of nerve injury and in the trigeminal ganglion; and (ii) the degree of demyelination and axonal reorganisation in the injured nerve...
March 16, 2024: Brain, Behavior, and Immunity
https://read.qxmd.com/read/38496621/thalamic-stimulation-induced-changes-in-effective-connectivity
#13
Nicholas M Gregg, Gabriela Ojeda Valencia, Harvey Huang, Brian N Lundstrom, Jamie J Van Gompel, Kai J Miller, Gregory A Worrell, Dora Hermes
Deep brain stimulation (DBS) is a viable treatment for a variety of neurological conditions, however, the mechanisms through which DBS modulates large-scale brain networks are unresolved. Clinical effects of DBS are observed over multiple timescales. In some conditions, such as Parkinson's disease and essential tremor, clinical improvement is observed within seconds. In many other conditions, such as epilepsy, central pain, dystonia, neuropsychiatric conditions or Tourette syndrome, the DBS related effects are believed to require neuroplasticity or reorganization and often take hours to months to observe...
March 4, 2024: medRxiv
https://read.qxmd.com/read/38491439/daoyin-therapy-in-chronic-neck-pain-study-protocol-for-a-randomized-controlled-trial
#14
JOURNAL ARTICLE
Xiangxu Chen, Mingze Zhu, Wei Li, Daan Wang, Jing Liu
BACKGROUND: Daoyin therapy (DT), an ancient therapeutic approach with a history spanning thousands of years, has traditionally been employed to address musculoskeletal pain and psychosomatic disorders. However, the application of DT for chronic neck pain (CNP) has received limited attention in the existing literature, and systematic randomized clinical trials (RCTs) in this context remain scarce. This manuscript outlines an RCT protocol designed to investigate whether DT is more effective at alleviating CNP in adult individuals compared to other interventions...
March 15, 2024: BMC complementary medicine and therapies
https://read.qxmd.com/read/38489380/photo-neuro-immuno-endocrinology-how-the-ultraviolet-radiation-regulates-the-body-brain-and-immune-system
#15
JOURNAL ARTICLE
Radomir M Slominski, Jake Y Chen, Chander Raman, Andrzej T Slominski
Ultraviolet radiation (UVR) is primarily recognized for its detrimental effects such as cancerogenesis, skin aging, eye damage, and autoimmune disorders. With exception of ultraviolet B (UVB) requirement in the production of vitamin D3, the positive role of UVR in modulation of homeostasis is underappreciated. Skin exposure to UVR triggers local responses secondary to the induction of chemical, hormonal, immune, and neural signals that are defined by the chromophores and extent of UVR penetration into skin compartments...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38486142/specific-cognitive-and-psychological-alterations-are-more-strongly-linked-to-increased-migraine-disability-than-chronic-migraine-diagnosis
#16
JOURNAL ARTICLE
Tatiana Castro Zamparella, Mariela Carpinella, Mario Peres, Florencia Patricia Cuello, Pilar Maza, Melanie Van Gansen, Marcelo Filipchuk, Verónica Balaszczuk, Carolina Maldonado, Pablo Scarnato, Diego Conci Magris, Marco Lisicki
INTRODUCTION: The efficiency of The International Classification of Headache Disorders (ICHD-3) in reflecting patients' disability has recently been questioned. This prompts consideration that clinical features beyond pain may more accurately indicate the extent of underlying brain impairment than the mere frequency of headache days. Important cognitive dysfunctions and psychological impairment have been reported in burdensome cases of migraine, and the presence of these alterations has been associated with biological changes in the nervous system...
March 15, 2024: Journal of Headache and Pain
https://read.qxmd.com/read/38471625/insular-cortex-stimulation-alleviates-neuropathic-pain-through-changes-in-the-expression-of-collapsin-response-mediator-protein-2-involved-in-synaptic-plasticity
#17
JOURNAL ARTICLE
Kyeongmin Kim, Guanghai Nan, Hyeji Bak, Hee Young Kim, Junesun Kim, Myeounghoon Cha, Bae Hwan Lee
In recent studies, brain stimulation has shown promising potential to alleviate chronic pain. Although studies have shown that stimulation of pain-related brain regions can induce pain-relieving effects, few studies have elucidated the mechanisms of brain stimulation in the insular cortex (IC). The present study was conducted to explore the changes in characteristic molecules involved in pain modulation mechanisms and to identify the changes in synaptic plasticity after IC stimulation (ICS). Following ICS, pain-relieving behaviors and changes in proteomics were explored...
March 10, 2024: Neurobiology of Disease
https://read.qxmd.com/read/38470516/chronic-pain-related-cognitive-deficits-preclinical-insights-into-molecular-cellular-and-circuit-mechanisms
#18
REVIEW
Siyi Han, Jie Wang, Wen Zhang, Xuebi Tian
Cognitive impairment is a common comorbidity of chronic pain, significantly disrupting patients' quality of life. Despite this comorbidity being clinically recognized, the underlying neuropathological mechanisms remain unclear. Recent preclinical studies have focused on the fundamental mechanisms underlying the coexistence of chronic pain and cognitive decline. Pain chronification is accompanied by structural and functional changes in the neural substrate of cognition. Based on the developments in electrophysiology and optogenetics/chemogenetics, we summarized the relevant neural circuits involved in pain-induced cognitive impairment, as well as changes in connectivity and function in brain regions...
March 12, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38469291/brain-imaging-derived-phenotypes-a-biomarker-for-the-onset-of-inflammatory-bowel-disease-and-a-potential-mediator-of-mental-complications
#19
JOURNAL ARTICLE
Fan Li, Qi Zhao, Tongyu Tang, Yuyuan Liu, Zhaodi Wang, Zhi Wang, Xiaoping Han, Zifeng Xu, Yu Chang, Yuqin Li
BACKGROUND AND AIMS: Inflammatory bowel disease (IBD), mainly categorized into Crohn's disease (CD) and ulcerative colitis (UC), is a chronic relapsing gastrointestinal disorder that significantly impairs patients' quality of life. IBD patients often experience comorbidities such as anxiety and depression, and the underlying mechanisms and treatment strategies remain areas of investigation. METHODS: We conducted a Mendelian randomization(MR) analysis utilizing brain image derived phenotypes (IDP) from the UK Biobank database to investigate the causal relationships between IBD and alterations in brain structural morphology and connectivity of neural tracts...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38467533/gender-specific-insights-into-the-irritable-bowel-syndrome-pathophysiology-focus-on-gut-dysbiosis-and-permeability
#20
REVIEW
Jerlin Stephy JohnBritto, Agostino Di Ciaula, Antonino Noto, Velia Cassano, Angela Sciacqua, Mohamad Khalil, Piero Portincasa, Leonilde Bonfrate
Irritable bowel syndrome (IBS) is the most common functional gastrointestinal disorder involving the brain-gut interaction. IBS is characterized by persistent abdominal pain and changes in bowel habits. IBS exerts significant impacts on quality of life and imposes huge economic costs. Global epidemiological data reveal variations in IBS prevalence, both globally and between genders, necessitating comprehensive studies to uncover potential societal and cultural influences. While the exact pathophysiology of IBS remains incompletely understood, the mechanism involves a dysregulation of the brain-gut axis, leading to disturbed intestinal motility, local inflammation, altered intestinal permeability, visceral sensitivity, and gut microbiota composition...
March 10, 2024: European Journal of Internal Medicine
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