Yuanyuan Wang, Xinying Zhang, Yiting Yao, Suwan Hu, Wenli Wang, Di Wang, Chaoli Huang, Hanyu Liu, Qi Zhang, Teng He, Sen Wang, Zifeng Wu, Riyue Jiang, Chun Yang
Social dominance is a universal phenomenon among grouped animals that profoundly affects survival, health, and reproductive success by determining access to resources, and exerting a powerful influence on subsequent behavior. However, the understanding of pain and anxiety comorbidities in dominant or subordinate animals suffering from chronic pain is not well-defined. Here, we provide evidence that subordinate mice are more susceptible to pain-induced anxiety compared to dominant mice. We propose that the gut microbiota may play a mediating role in this mechanism...
January 4, 2024: Neurobiology of Disease