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Chronic pain AND neurobiology

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https://www.readbyqxmd.com/read/29146590/camkii%C3%AE-mediates-the-effect-of-il-17-to-promote-ongoing-spontaneous-and-evoked-pain-in-multiple-sclerosis
#1
Xiaoyu Hu, Fang Huang, Zaijie Jim Wang
Pain is a common and severe symptom in multiple sclerosis (MS), a chronic inflammatory and demyelinating disease of the central nervous system. The neurobiological mechanism underlying MS pain is poorly understood. In this study, we investigated the role of Ca(2+)/calmodulin dependent kinase type IIα (CaMKIIα) in driving chronic pain in MS using a mouse experimental autoimmune encephalomyelitis (EAE) model. We found that spinal CaMKIIα activity was enhanced in EAE correlating with the development of ongoing spontaneous pain and evoked hypersensitivity to mechanical and thermal stimuli...
November 16, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29097192/the-endocannabinoid-system-and-its-therapeutic-exploitation-in-multiple-sclerosis-clues-for-other-neuroinflammatory-diseases
#2
REVIEW
Valerio Chiurchiù, Mario van der Stelt, Diego Centonze, Mauro Maccarrone
Multiple sclerosis is the most common inflammatory demyelinating disease of the central nervous system, caused by an autoimmune response against myelin that eventually leads to progressive neurodegeneration and disability. Although the knowledge on its underlying neurobiological mechanisms has considerably improved, there is a still unmet need for new treatment options, especially for the progressive forms of the disease. Both preclinical and clinical data suggest that cannabinoids, derived from the Cannabis sativa plant, may be used to control symptoms such as spasticity and chronic pain, whereas only preclinical data indicate that these compounds and their endogenous counterparts, i...
October 31, 2017: Progress in Neurobiology
https://www.readbyqxmd.com/read/29080714/hippocampal-morphology-mediates-biased-memories-of-chronic-pain
#3
Sara E Berger, Étienne Vachon-Presseau, Taha B Abdullah, Alex T Baria, Thomas J Schnitzer, A Vania Apkarian
Experiences and memories are often mismatched. While multiple studies have investigated psychological underpinnings of recall error with respect to emotional events, the neurobiological mechanisms underlying the divergence between experiences and memories remain relatively unexplored in the domain of chronic pain. Here we examined the discrepancy between experienced chronic low back pain (CBP) intensity (twice daily ratings) and remembered pain intensity (n = 48 subjects) relative to psychometric properties, hippocampus morphology, memory capabilities, and personality traits related to reward...
November 6, 2017: NeuroImage
https://www.readbyqxmd.com/read/29077871/from-mechanism-to-cure-renewing-the-goal-to-eliminate-the-disease-of-pain
#4
Theodore J Price, Michael S Gold
Objective: Persistent pain causes untold misery worldwide and is a leading cause of disability. Despite its astonishing prevalence, pain is undertreated, at least in part because existing therapeutics are ineffective or cause intolerable side effects. In this review, we cover new findings about the neurobiology of pain and argue that all but the most transient forms of pain needed to avoid tissue damage should be approached as a disease where a cure can be the goal of all treatment plans, even if attaining this goal is not yet always possible...
October 25, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29068872/dopaminergic-tone-does-not-influence-pain-levels-during-placebo-interventions-in-patients-with-chronic-neuropathic-pain
#5
Ina Skyt, Kurosh Moslemi, Cathrine Baastrup, Kasper Grosen, Fabrizio Benedetti, Gitte L Petersen, Donald D Price, Kathryn T Hall, Ted J Kaptchuk, Peter Svensson, Troels S Jensen, Lene Vase
Placebo effects have been reported in patients with chronic neuropathic pain. Expected pain levels and positive emotions are involved in the observed pain relief, but the underlying neurobiology is largely unknown. Patients with neuropathic pain are highly motivated for pain relief, and as motivational factors such as expectations of reward, as well as pain processing in itself, are related to the dopaminergic system, it can be speculated that dopamine release contributes to placebo effects in neuropathic pain...
October 23, 2017: Pain
https://www.readbyqxmd.com/read/29024786/neurobiological-correlates-of-pain-avoidance-like-behavior-in-morphine-dependent-and-non-dependent-rats
#6
Amanda R Pahng, Rod I Paulsen, M Adrienne McGinn, Kimberly N Edwards, Scott Edwards
Repeated use of opioids can lead to the development of analgesic tolerance and dependence. Additionally, chronic opioid exposure can cause a paradoxical emergence of heightened pain sensitivity to noxious stimuli, termed hyperalgesia, which may drive continued or escalated use of opioids to manage worsening pain symptoms. Opioid-induced hyperalgesia has traditionally been measured in rodents via reflex-based assays, including the von Frey method. To better model the cognitive/motivational dimension of pain in a state of opioid dependence and withdrawal, we employed a recently developed non-reflex-based method for measuring pain avoidance-like behavior in animals (mechanical conflict avoidance test)...
October 9, 2017: Neuroscience
https://www.readbyqxmd.com/read/29016379/oxidative-stress-inflammation-and-neuroprogression-in-chronic-ptsd
#7
Mark W Miller, Alex P Lin, Erika J Wolf, Danielle R Miller
Posttraumatic stress disorder is a serious and often disabling syndrome that develops in response to a traumatic event. Many individuals who initially develop the disorder go on to experience a chronic form of the condition that in some cases can last for many years. Among these patients, psychiatric and medical comorbidities are common, including early onset of age-related conditions such as chronic pain, cardiometabolic disease, neurocognitive disorders, and dementia. The hallmark symptoms of posttraumatic stress-recurrent sensory-memory reexperiencing of the trauma(s)-are associated with concomitant activations of threat- and stress-related neurobiological pathways that occur against a tonic backdrop of sleep disturbance and heightened physiological arousal...
October 9, 2017: Harvard Review of Psychiatry
https://www.readbyqxmd.com/read/28968188/the-opioid-epidemic-crisis-and-solutions
#8
Phil Skolnick
The widespread abuse of prescription opioids and a dramatic increase in the availability of illicit opioids have created what is commonly referred to as the opioid epidemic. The magnitude of this epidemic is startling: About 4% of the adult US population misuses prescription opioids, and in 2015, more than 33,000 deaths were attributable to overdose with licit and illicit opioids. Increasing the availability of medication-assisted treatments (such as buprenorphine and naltrexone), the use of abuse-deterrent formulations, and the adoption of US Centers for Disease Control and Prevention prescribing guidelines all constitute short-term approaches to quell this epidemic...
October 2, 2017: Annual Review of Pharmacology and Toxicology
https://www.readbyqxmd.com/read/28967364/open-issues-in-the-assessment-and-management-of-pain-in-juvenile-idiopathic-arthritis
#9
REVIEW
Gabriella Giancane, Alessandra Alongi, Silvia Rosina, Serena Calandra, Alessandro Consolaro, Angelo Ravelli
Pain is the major symptom of children with juvenile idiopathic arthritis (JIA) and its reduction is a key goal of treatment. It is widely agreed that assessment of pain is a fundamental component of the rheumatology evaluation and should be carried out at each clinic visit. However, so far there has been insufficient attention to the impact and causes of pain in children with chronic arthritis in both clinical practice and research. Quantitative measures of pain are seldom used regularly in daily care and pain assessment has not been incorporated in the most popular composite outcome measures for JIA, including the criteria employed to measure improvement in therapeutic trials...
September 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28935098/your-system-has-been-hijacked-the-neurobiology-of-chronic-pain
#10
Erica B Baller, David A Ross
No abstract text is available yet for this article.
October 15, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28880891/altered-right-anterior-insular-connectivity-and-loss-of-associated-functions-in-adolescent-chronic-fatigue-syndrome
#11
Laura Anne Wortinger, Merete Glenne Øie, Tor Endestad, Vegard Bruun Wyller
Impairments in cognition, pain intolerance, and physical inactivity characterize adolescent chronic fatigue syndrome (CFS), yet little is known about its neurobiology. The right dorsal anterior insular (dAI) connectivity of the salience network provides a motivational context to stimuli. In this study, we examined regional functional connectivity (FC) patterns of the right dAI in adolescent CFS patients and healthy participants. Eighteen adolescent patients with CFS and 18 aged-matched healthy adolescent control participants underwent resting-state functional magnetic resonance imaging...
2017: PloS One
https://www.readbyqxmd.com/read/28858914/neuropathic-symptoms-of-the-ocular-surface-dryness-pain-and-itch
#12
Hjalte H Andersen, Gil Yosipovitch, Anat Galor
PURPOSE OF REVIEW: This review aims to describe the recent findings on epidemiology, pathophysiology, and management of neuropathic symptoms of the ocular surface, with a focus on potential similarities between sensations of dry eye, pain and itch. RECENT FINDINGS: A narrative review of the literature was undertaken. Key references from research in dry eye, neuropathic symptoms of the ocular surface, ocular pain and itch, as well as general references on itch and pain neurobiology were included...
October 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28855788/an-abbreviated-therapeutic-neuroscience-education-session-improves-pain-knowledge-in-first-year-physical-therapy-students-but-does-not-change-attitudes-or-beliefs
#13
Terry Cox, Adriaan Louw, Emilio J Puentedura
OBJECTIVE: To determine if a 3-hour therapeutic neuroscience education session alters physical therapy student's knowledge of pain and effects their attitudes and beliefs regarding treating chronic pain. METHODS: Seventy-seven entry-level doctoral physical therapy students participated in the study. Following consent, demographic data were obtained and then the subjects completed the Neuroscience of Pain Questionnaire, the Health Care Provider's Pain and Impairment Relationship Scale and an additional questionnaire designed by the researchers...
February 2017: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/28725185/reticular-formation-and-pain-the-past-and-the-future
#14
REVIEW
Isabel Martins, Isaura Tavares
The involvement of the reticular formation (RF) in the transmission and modulation of nociceptive information has been extensively studied. The brainstem RF contains several areas which are targeted by spinal cord afferents conveying nociceptive input. The arrival of nociceptive input to the RF may trigger alert reactions which generate a protective/defense reaction to pain. RF neurons located at the medulla oblongata and targeted by ascending nociceptive information are also involved in the control of vital functions that can be affected by pain, namely cardiovascular control...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28706741/the-link-between-depression-and-chronic-pain-neural-mechanisms-in-the-brain
#15
REVIEW
Jiyao Sheng, Shui Liu, Yicun Wang, Ranji Cui, Xuewen Zhang
Chronic pain, as a stress state, is one of the critical factors for determining depression, and their coexistence tends to further aggravate the severity of both disorders. Unfortunately, their association remains unclear, which creates a bottleneck problem for managing chronic pain-induced depression. In recent years, studies have found considerable overlaps between pain- and depression-induced neuroplasticity changes and neurobiological mechanism changes. Such overlaps are vital to facilitating the occurrence and development of chronic pain and chronic pain-induced depression...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28694679/a-clinical-perspective-on-a-pain-neuroscience-education-approach-to-manual-therapy
#16
Adriaan Louw, Jo Nijs, Emilio J Puentedura
In recent years, there has been an increased interest in pain neuroscience education (PNE) in physical therapy. There is growing evidence for the efficacy of PNE to decrease pain, disability, fear-avoidance, pain catastrophization, limited movement, and health care utilization in people struggling with pain. PNE teaches people in pain more about the biology and physiology of their pain experience including processes such as central sensitization, peripheral sensitization, allodynia, inhibition, facilitation, neuroplasticity and more...
July 2017: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/28666966/aapt-diagnostic-criteria-for-central-neuropathic-pain
#17
Eva Widerström-Noga, John D Loeser, Troels Staehelin Jensen, Nanna Brix Finnerup
Central neuropathic pain, which is pain caused by a lesion or disease of the central somatosensory nervous system, is a serious consequence of spinal cord injury, stroke, multiple sclerosis, and other conditions affecting the central nervous system. A collaborative effort between the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks public-private partnership and the American Pain Society, the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks-American Pain Society Pain Taxonomy (AAPT) initiative, invited a working group to develop diagnostic criteria for central neuropathic pain...
December 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28664196/postinflammatory-hyperpigmentation-after-human-cold-pain-testing
#18
Melissa J Wolz, Katelyn E Sadler, Caela C Long, Daniel S Brenner, Brian S Kim, Robert W Gereau, Benedict J Kolber
Changes in cold temperature sensitivity are often associated with chronic pain conditions. Progress in understanding the neurobiological mechanism underlying these changes and resulting development of effective therapies has been slowed by the accessibility and affordability of devices used to measure thermal sensitivity in humans. To address this gap, we developed an inexpensive method to measure cold pain thresholds in healthy adult volunteers using dry ice and a thermode. However, early in preliminary testing, a subject presented with epidermal postinflammatory hyperpigmentation that lasted for >200 days...
August 2016: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/28616655/-cognitive-perceptive-approaches-in-the-treatment-of-chronic-pain
#19
REVIEW
C Storz, H Schulte-Göcking, M Azqueta, C Wania, M Neugebauer, A Reiners, S Azad, E Kraft
In the treatment of difficult chronic pain conditions, cognitive-perceptive approaches offer an alternative to conventional therapies. Especially phantom limb pain and complex regional pain syndrome (CRPS) are frequently treated with these promising modalities. This article provides an overview of the most important cognitive-perceptive therapies and the research results concerning their clinical efficacy. In addition, we discuss their neurobiological foundation and clinical perspectives.
October 2017: Der Schmerz
https://www.readbyqxmd.com/read/28602044/the-dynamic-interaction-between-pain-and-opioid-misuse
#20
REVIEW
Adrianne R Wilson-Poe, Jose A Morón
In 2014, drug overdose surpassed automobile accidents as the number one cause of accidental death for the first time in the history of the United States. The overdose epidemic is largely driven by opioids, and genuine prescription opioid analgesics play the biggest role in this phenomenon. Despite advancements in abuse deterrent formulations, prescription drug monitoring programmes and clinical assessments for the detection of abuse potential, drug overdoses continue to escalate. The Center for Disease Control has recently issued new guidelines for opioid prescription, yet even these recommendations have their shortcomings...
June 11, 2017: British Journal of Pharmacology
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