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Chronic pain AND neurobiology

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https://www.readbyqxmd.com/read/28228081/the-neurobiology-and-psychiatric-perspective-of-vaginismus-linking-the-pharmacological-and-psycho-social-interventions
#1
Zuri Shahidii Kadir, Hatta Sidi, Jaya Kumar, Srijit Das, Marhani Midin, Najwa Baharuddin
Vaginismus is an involuntary muscle contraction of the outer third of vaginal barrel causing sexual penetration almost impossible. It is generally classified under sexual pain disorder (SPD). In Diagnostic and Statistical Manual, 5th edition, it is classified under the new rubric of Genito-Pelvic Pain/Sexual Penetration Disorder. This fear-avoidance condition poses an ongoing significant challenge to the medical and health professionals due to the very demanding needs in health care despite its unpredictable prognosis...
February 22, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28216087/neural-consequences-of-post-exertion-malaise-in-myalgic-encephalomyelitis-chronic-fatigue-syndrome
#2
Dane B Cook, Alan R Light, Kathleen C Light, Gordon Broderick, Morgan R Shields, Ryan J Dougherty, Jacob D Meyer, Stephanie VanRiper, Aaron J Stegner, Laura D Ellingson, Suzanne D Vernon
Post exertion malaise is one of the most debilitating aspects of Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome, yet the neurobiological consequences are largely unexplored. The objective of the study was to determine the neural consequences of acute exercise using functional brain imaging. Fifteen female Myalgic Encephalomyelitis/Chronic Fatigue Syndrome patients and 15 healthy female controls completed 30 minutes of submaximal exercise (70% of peak heart rate) on a cycle ergometer. Symptom assessments (e...
February 16, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28199203/neurogenetics-of-acute-and-chronic-opiate-opioid-abstinence-treating-symptoms-and-the-cause
#3
Kenneth Blum, Mark S Gold, William Jacobs, William Vaughn McCall, Marcelo Febo, David Baron, Kristina Dushaj, Zsolt Demetrovics, Rajendra D Badgaiyan
This review begins with a comprehensive history of opioid dependence and treatment in the United States. The focus is an evidence-based treatment model for opioid/opiate dependent individuals. The role of reward genetic polymorphisms and the epigenetic modifications that lead to vulnerability to use and misuse of opiates/opioid to treat pain are reviewed. The neurochemical mechanisms of acute opiate withdrawal and opiate/opioid reward mechanisms are explored with a goal of identifying specific treatment targets...
March 1, 2017: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28129218/neurobiological-basis-for-pain-vulnerability-why-me
#4
Franziska Denk, Stephen B McMahon
Not everyone is equally likely to develop chronic pain. This review sets out to discuss the underlying neurobiological reasons that might make some of us unfortunate patients, while others are spared. We will show that genetic factors are likely to play a role in many patients, but that their exact identity has proven difficult to determine and remains, to a large extent, elusive. We will also discuss how the environment can impact how likely we are to develop chronic pain, and summarize early tentative evidence for how this might come about biologically...
January 24, 2017: Pain
https://www.readbyqxmd.com/read/28114184/pain-has-an-element-of-blank-a-biobehavioral-approach-to-chronicity
#5
Herta Flor
The development of acute to chronic pain is characterized by a shift from nociceptive brain circuits to those involved in emotion, motivation, cognition and learning. Psychological, psychosocial, genetic and neurobiological determinants of these evolving brain circuits are discussed and it is suggested that different concepts ofchronicity may have a common psychobiological basis. The analysis of these chronicity factors leads to the identification of psychobiological mechanisms of chronicity andmay change the classification of pain syndromes from a mainly descriptive to a mechanistic basis...
January 18, 2017: Pain
https://www.readbyqxmd.com/read/28074359/pharmacological-management-of-chronic-pelvic-pain-in-women
#6
REVIEW
Erin T Carey, Sara R Till, Sawsan As-Sanie
Chronic pelvic pain (CPP) is a multifaceted condition that often has both peripheral and central generators of pain. An understanding of neurobiology and neuropsychology of CPP should guide management. Successful treatment of CPP is typically multimodal, and pharmacologic treatment strategies include analgesics, hormonal suppression, anesthetics, antidepressants, membrane stabilizers, and anxiolytics. Evidence for these and other emerging pharmacologic therapies is presented in this article.
January 10, 2017: Drugs
https://www.readbyqxmd.com/read/28072813/a-case-report-on-red-ear-syndrome-with-tinnitus-successfully-treated-with-transcranial-random-noise-stimulation
#7
Peter M Kreuzer, Veronika Vielsmeier, Timm B Poeppl, Berthold Langguth
BACKGROUND: The red ear syndrome represents a rare symptom complex consisting of auricular erythema associated with painful and burning sensations. It has been described in combination with tinnitus rarely. It has been hypothesized to be etiologically related to altered trigeminal afferent input, temporomandibular disorders, and thalamic dysfunction. OBJECTIVES: The initial objective of applying transcranial random noise stimulation (tRNS) in a case of red ear syndrome in combination with tinnitus was the alleviation of the phantom sounds...
January 2017: Pain Physician
https://www.readbyqxmd.com/read/28069928/functional-organization-of-cutaneous-and-muscle-afferent-synapses-onto-immature-spinal-lamina-i-projection-neurons
#8
Jie Li, Mark L Baccei
It is well established that sensory afferents innervating muscle are more effective at inducing hyperexcitability within spinal cord circuits compared with skin afferents, which likely contributes to the higher prevalence of chronic musculoskeletal pain compared with pain of cutaneous origin. However, the mechanisms underlying these differences in central nociceptive signaling remain incompletely understood, as nothing is known about how superficial dorsal horn neurons process sensory input from muscle versus skin at the synaptic level...
February 8, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27986927/histological-underpinnings-of-grey-matter-changes-in-fibromyalgia-investigated-using-multimodal-brain-imaging
#9
F B Pomares, T Funck, N A Feier, S Roy, A Daigle-Martel, M Ceko, S Narayanan, D Araujo, A Thiel, N Stikov, M A Fitzcharles, P Schweinhardt
: Chronic pain patients present with cortical grey matter alterations, observed with anatomical magnetic resonance (MR) imaging. Reduced regional grey matter volumes are often interpreted to reflect neurodegeneration but studies investigating the cellular origin of grey matter changes are lacking. We used multi-modal imaging to compare 26 post-menopausal women with 25 healthy controls (age range: 50-75 years) to test whether regional grey matter volume decreases in chronic pain are associated with compromised neuronal integrity...
December 16, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27939459/molecular-mechanisms-of-pruritus
#10
REVIEW
J Meng, M Steinhoff
Pruritus is an unpleasant sensation that evokes the urgent desire to scratch. It is a symptom derived from many nervous system disorders that affects a large population of humans and is treated by a variety of pharmacological agents with variable access. Chronic itch is a huge unmet health problem which affect upward 20% of people worldwide. The mechanisms underlying the chronic pruritus are complex. Studies of the neurobiology, neurophysiology and cellular biology of itch have gradually been clarifying the mechanism of chronic itch both peripherally and centrally...
October 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27918444/mental-health-comorbidities-in-pediatric-chronic-pain-a-narrative-review-of-epidemiology-models-neurobiological-mechanisms-and-treatment
#11
REVIEW
Jillian Vinall, Maria Pavlova, Gordon J G Asmundson, Nivez Rasic, Melanie Noel
Chronic pain during childhood and adolescence can lead to persistent pain problems and mental health disorders into adulthood. Posttraumatic stress disorders and depressive and anxiety disorders are mental health conditions that co-occur at high rates in both adolescent and adult samples, and are linked to heightened impairment and disability. Comorbid chronic pain and psychopathology has been explained by the presence of shared neurobiology and mutually maintaining cognitive-affective and behavioral factors that lead to the development and/or maintenance of both conditions...
December 2, 2016: Children
https://www.readbyqxmd.com/read/27870423/sex-based-differences-in-brain-alterations-across-chronic-pain-conditions
#12
REVIEW
Arpana Gupta, Emeran A Mayer, Connor Fling, Jennifer S Labus, Bruce D Naliboff, Jui-Yang Hong, Lisa A Kilpatrick
Common brain mechanisms are thought to play a significant role across a multitude of chronic pain syndromes. In addition, there is strong evidence for the existence of sex differences in the prevalence of chronic pain and in the neurobiology of pain. Thus, it is important to consider sex when developing general principals of pain neurobiology. The goal of the current Mini-Review is to evaluate what is known about sex-specific brain alterations across multiple chronic pain populations. A total of 15 sex difference and 143 single-sex articles were identified from among 412 chronic pain neuroimaging articles...
January 2, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27852966/hippocampal-activation-of-microglia-may-underlie-the-shared-neurobiology-of-comorbid-posttraumatic-stress-disorder-and-chronic-pain
#13
Rao Sun, Zuoxia Zhang, Yishan Lei, Yue Liu, Cui'e Lu, Hui Rong, Yu'e Sun, Wei Zhang, Zhengliang Ma, Xiaoping Gu
The high comorbidity rates of posttraumatic stress disorder and chronic pain have been widely reported, but the underlying mechanisms remain unclear. Emerging evidence suggested that an excess of inflammatory immune activities in the hippocampus involved in the progression of both posttraumatic stress disorder and chronic pain. Considering that microglia are substrates underlying the initiation and propagation of the neuroimmune response, we hypothesized that stress-induced activation of hippocampal microglia may contribute to the pathogenesis of posttraumatic stress disorder-pain comorbidity...
2016: Molecular Pain
https://www.readbyqxmd.com/read/27816599/etiology-and-treatment-of-pain-and-psychosocial-issues-in%C3%A2-patients-with-inflammatory-bowel-diseases
#14
Miguel Regueiro, Julia B Greer, Eva Szigethy
There is increasing evidence that brain-gut interactions are altered during development of inflammatory bowel diseases (IBDs). Understanding the relationship between the neurobiology, psychological symptoms, and social ramifications of IBD can guide comprehensive care for the whole patient. The most common psychological conditions in patients with IBD are chronic abdominal pain, anxiety, and depression. We review the evidence-based data and rates of these conditions and their respective relationship to IBD and the diagnostic approaches to identify patients with these conditions...
February 2017: Gastroenterology
https://www.readbyqxmd.com/read/27784343/patterns-of-association-of-chronic-medical-conditions-and-major-depression
#15
S B Patten, J V A Williams, D H Lavorato, J L Wang, N Jetté, T T Sajobi, K M Fiest, A G M Bulloch
AIMS: Age and sex-related patterns of association between medical conditions and major depressive episodes (MDE) are important for understanding disease burden, anticipating clinical needs and for formulating etiological hypotheses. General population estimates are especially valuable because they are not distorted by help-seeking behaviours. However, even large population surveys often deliver inadequate precision to adequately describe such patterns. In this study, data from a set of national surveys were pooled to increase precision, supporting more precise characterisation of these associations...
October 27, 2016: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/27778031/-application-of-optogenetic-technique-in-pain-research
#16
Yi Li, Han Hao, Hai-Lin Zhang, Xiao-Na DU
Chronic pain represents a major clinical issue which so far is still in shortage of selective and effective treatment. Multiple components are involved in the pain processing, including peripheral, spinal and supraspinal levels of the nervous system. The core to fight the pain problem effectively is to have a good understanding of nociceptive mechanism and the neurobiology of pain perception. Optogenetic technique allows selective activation of subpopulation neurons and provides possibility for better understanding of complex pathway and modulation mechanism in nervous system...
October 25, 2016: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/27687118/mindfulness-interventions
#17
J David Creswell
Mindfulness interventions aim to foster greater attention to and awareness of present moment experience. There has been a dramatic increase in randomized controlled trials (RCTs) of mindfulness interventions over the past two decades. This article evaluates the growing evidence of mindfulness intervention RCTs by reviewing and discussing (a) the effects of mindfulness interventions on health, cognitive, affective, and interpersonal outcomes; (b) evidence-based applications of mindfulness interventions to new settings and populations (e...
January 3, 2017: Annual Review of Psychology
https://www.readbyqxmd.com/read/27685982/the-noradrenergic-locus-coeruleus-as-a-chronic-pain-generator
#18
REVIEW
Bradley K Taylor, Karin N Westlund
Central noradrenergic centers such as the locus coeruleus (LC) are traditionally viewed as pain inhibitory; however, complex interactions among brainstem pathways and their receptors modulate both inhibition and facilitation of pain. In addition to the well-described role of descending pontospinal pathways that inhibit spinal nociceptive transmission, an emerging body of research now indicates that noradrenergic neurons in the LC and their terminals in the dorsal reticular nucleus (DRt), medial prefrontal cortex (mPFC), spinal dorsal horn, and spinal trigeminal nucleus caudalis participate in the development and maintenance of allodynia and hyperalgesia after nerve injury...
September 29, 2016: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27621368/the-effects-of-extended-pain-on-behavior-recent-progress
#19
REVIEW
Ted B Usdin, Eugene L Dimitrov
Chronic pain is frequently associated with anxiety, depression, and cognitive dysfunction. This review discusses recent work in rodents that contributes to the understanding of their neurobiological links. Brain regions that contain circuits that mediate persistent changes in behavior that are caused by nerve injury or joint inflammation include the rostral anterior cingulate and other parts of the medial prefrontal cortex, the basolateral and central nucleus of the amygdala, and the nucleus accumbens. Functional changes, including increases in the activity within specific neuronal pathways and in the levels of specific synaptic components, that are associated with the behavior changes, or are in some cases necessary for them, have recently been identified...
October 2016: Neuroscientist: a Review Journal Bringing Neurobiology, Neurology and Psychiatry
https://www.readbyqxmd.com/read/27586830/assessment-of-psychosocial-and-functional-impact-of-chronic-pain
#20
Dennis C Turk, Roger B Fillingim, Richard Ohrbach, Kushang V Patel
UNLABELLED: The psychosocial and functional consequences of chronic pain disorders have been well documented as having significant effects on the experience of pain, presentation to health care providers, responsiveness to and participation in treatment, disability, and health-related quality of life. Thus, psychosocial and functional consequences have been incorporated as 1 of the 5 dimensions within the integrated Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION)-American Pain Society (APS) Pain Taxonomy (AAPT): 1) core diagnostic criteria; 2) common features; 3) common medical comorbidities; 4) neurobiological, psychosocial, and functional consequences; and 5) putative neurobiological and psychosocial mechanisms, risk factors, and protective factors...
September 2016: Journal of Pain: Official Journal of the American Pain Society
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