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Chronic pain AND brain changes

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https://www.readbyqxmd.com/read/28216087/neural-consequences-of-post-exertion-malaise-in-myalgic-encephalomyelitis-chronic-fatigue-syndrome
#1
Dane B Cook, Alan R Light, Kathleen C Light, Gordon Broderick, Morgan R Shields, Ryan J Dougherty, Jacob D Meyer, Stephanie VanRiper, Aaron J Stegner, Laura D Ellingson, Suzanne D Vernon
Post exertion malaise is one of the most debilitating aspects of Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome, yet the neurobiological consequences are largely unexplored. The objective of the study was to determine the neural consequences of acute exercise using functional brain imaging. Fifteen female Myalgic Encephalomyelitis/Chronic Fatigue Syndrome patients and 15 healthy female controls completed 30 minutes of submaximal exercise (70% of peak heart rate) on a cycle ergometer. Symptom assessments (e...
February 16, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28203104/proton-magnetic-resonance-spectroscopy-assessment-of-metabolite-status-of-the-anterior-cingulate-cortex-in-chronic-pain-patients-and-healthy-controls
#2
Takahiro Ito, Sachiko Tanaka-Mizuno, Narihito Iwashita, Ikuo Tooyama, Akihiko Shiino, Katsuyuki Miura, Sei Fukui
BACKGROUND: Chronic pain is a common cause of reduced quality of life. Recent studies suggest that chronic pain patients have a different brain neurometabolic status to healthy people. Proton magnetic resonance spectroscopy ((1)H-MRS) can determine the concentrations of metabolites in a specific region of the brain without being invasive. PATIENTS AND METHODS: We recruited 56 chronic pain patients and 60 healthy controls to compare brain metabolic characteristics...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28191693/gene-expression-profiles-in-peripheral-blood-mononuclear-cells-correlate-with-salience-network-activity-in-chronic-visceral-pain-a-pilot-study
#3
A Gupta, S Cole, J S Labus, S Joshi, T J Nguyen, L A Kilpatrick, K Tillisch, B D Naliboff, L Chang, E A Mayer
BACKGROUND: Distinct gene expression profiles in peripheral blood mononuclear cells (PBMCs) consistent with increased sympathetic nervous system activity have been described in different populations under chronic stress. Neuroinflammatory brain changes, possibly related to the migration of primed monocytes to the brain, have been implicated in the pathophysiology of chronic pain. Irritable bowel syndrome (IBS) is a stress-sensitive gastrointestinal disorder associated with altered brain-gut interactions and increased sympathetic/vagal tone and anxiety...
February 12, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28179153/activation-of-npffr2-leads-to-hyperalgesia-through-the-spinal-inflammatory-mediator-cgrp-in-mice
#4
Ya-Tin Lin, Ho-Ling Liu, Yuan-Ji Day, Che-Chien Chang, Po-Hung Hsu, Jin-Chung Chen
Neuropeptide FF (NPFF) is recognized as an opioid modulating peptide that regulates morphine-induced analgesia. The aim of this study was to delineate the role of NPFFR2 in pain transmission. We found the expression levels of NPFF and NPFFR2 were increased in the lumbar dorsal horn of animals with CFA- and carrageenan-induced inflammation and both NPFFR2 over-expressing transgenic (NPFFR2-Tg) and NPFFR2 agonist-treated mice displayed hyperalgesia. BOLD signals from functional MRI showed that NPFFR2-Tg mice exhibited increased activation of pain-related brain regions after painful stimulation when compared to WT mice...
February 5, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28167076/brain-network-alterations-in-the-inflammatory-soup-animal-model-of-migraine
#5
Lino Becerra, James Bishop, Gabi Barmettler, Vanessa Kainz, Rami Burstein, David Borsook
Advances in our understanding of the human pain experience have shifted much of the focus of pain research from the periphery to the brain. Current hypotheses suggest that the progression of migraine depends on abnormal functioning of neurons in multiple brain regions. Accordingly, we sought to capture functional brain changes induced by the application of an inflammatory cocktail known as inflammatory soup (IS), to the dura mater across multiple brain networks. Specifically, we aimed to determine whether IS alters additional neural networks indirectly related to the primary nociceptive pathways via the spinal cord to the thalamus and cortex...
February 3, 2017: Brain Research
https://www.readbyqxmd.com/read/28160750/repetitive-peripheral-magnetic-neurostimulation-of-multifidus-muscles-combined-with-motor-training-influences-spine-motor-control-and-chronic-low-back-pain
#6
Hugo Massé-Alarie, Louis-David Beaulieu, Richard Preuss, Cyril Schneider
OBJECTIVE: The study tested whether combining repetitive peripheral magnetic stimulation (RPMS) and motor training of the superficial multifidus muscle (MF) better improved the corticomotor control of spine than training alone in chronic low back pain (CLBP). METHODS: Twenty-one participants with CLBP were randomly allocated to [RPMS+training] and [Sham+training] groups for three sessions (S1-S3) over a week where MF was stimulated before training (volitional contraction)...
March 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28158166/abnormal-local-brain-activity-beyond-the-pain-matrix-in-postherpetic-neuralgia-patients-a-resting-state-functional-mri-study
#7
Song Cao, Ganjun Song, Yi Zhang, Peng Xie, Ye Tu, Ying Li, Tian Yu, Buwei Yu
BACKGROUND: Postherpetic neuralgia (PHN) patients suffer debilitating chronic pain, hyperalgesia, and allodynia, as well as emotional disorders such as insomnia, anxiety, and depression. The brain structure and functional basis of PHN are still not fully understood. OBJECTIVES: To identify the changes of regional brain activity in resting-state PHN patients using regional homogeneity (ReHo) and fractional aptitude of low-frequency fluctuation (fALFF) methods. Correlations between spontaneous pain intensity and ReHo or fALFF were analyzed...
February 2017: Pain Physician
https://www.readbyqxmd.com/read/28158153/trigeminal-neuralgia-induced-by-cobra-venom-leads-to-cognitive-deficits-associated-with-downregulation-of-creb-bdnf-pathway
#8
Li Zhang, Xinli Ding, Zhe Wu, Xiaoyan Qian, Jianxiong An, Ming Tian
BACKGROUND: Chronic pain often results in cognitive impairment. Our previous study showed that trigeminal neuralgia induced by cobra venom leads to spatial learning and memory deficits, although the underlying mechanism remains unclear. However, recent evidence indicates that the c-AMP-responsive element binding protein (CREB)/brain derived neurotrophic factor (BDNF) pathway plays a critical role in various etiologies of cognitive deficits. OBJECTIVES: Our aim was to explore the CREB/BDNF pathway to determine the molecular mechanisms involved in the pathogenesis of cognitive impairment caused by cobra venom-induced trigeminal neuralgia...
February 2017: Pain Physician
https://www.readbyqxmd.com/read/28146317/attentional-performance-may-help-to-identify-duloxetine-responders-in-chronic-pain-fibromyalgia-patients
#9
G Schmidt, R Alvarenga, A Manhães, S Schmidt
BACKGROUND: Long-term pain affects brain in response to attention tasks. This study aimed to verify the relationship between performance in a computerized visual attention test (CVAT) and response to duloxetine in fibromyalgia patients. Duloxetine is approved for the treatment but the response is not immediate. METHODS: Patients were drawn from a sample of 74 patients with chronic pain. These patients were selected because they kept their subjective perceptions of pain as severe after 1 week of duloxetine treatment...
February 1, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28146315/brain-changes-associated-with-cognitive-and-emotional-factors-in-chronic-pain-a-systematic-review
#10
REVIEW
A Malfliet, I Coppieters, P Van Wilgen, J Kregel, R De Pauw, M Dolphens, K Ickmans
: An emerging technique in chronic pain research is MRI, which has led to the understanding that chronic pain patients display brain structure and function alterations. Many of these altered brain regions and networks are not just involved in pain processing, but also in other sensory and particularly cognitive tasks. Therefore, the next step is to investigate the relation between brain alterations and pain related cognitive and emotional factors. This review aims at providing an overview of the existing literature on this subject...
February 1, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28145509/serum-protein-changes-in-a-rat-model-of-chronic-pain-show-a-correlation-between-animal-and-humans
#11
Elisa Bellei, Antonietta Vilella, Emanuela Monari, Stefania Bergamini, Aldo Tomasi, Aurora Cuoghi, Simona Guerzoni, Letizia Manca, Michele Zoli, Luigi Alberto Pini
In previous works we showed the overexpression of some proteins in biological fluids from patients suffering chronic pain. In this proteomic study we analysed serum from a rat model of neuropathic pain obtained by the chronic constriction injury (CCI) of sciatic nerve, at two time intervals, 2 and 5 weeks after the insult, to find proteins involved in the expression or mediation of pain. Sham-operated and CCI rats were treated with saline or indomethacin. Two weeks after ligation, we identified three serum proteins overexpressed in CCI rats, two of which, alpha-1-macroglobulin and vitamin D-binding protein (VDBP), remained increased 5 weeks post-surgery; at this time interval, we found increased levels of further proteins, namely apolipoprotein A-I (APOA1), apolipoprotein E (APOE), prostaglandin-H2 D-isomerase (PTGDS) and transthyretin (TTR), that overlap the overexpressed proteins found in humans...
February 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28144827/biomarkers-for-musculoskeletal-pain-conditions-use-of-brain-imaging-and-machine-learning
#12
REVIEW
Jeff Boissoneault, Landrew Sevel, Janelle Letzen, Michael Robinson, Roland Staud
Chronic musculoskeletal pain condition often shows poor correlations between tissue abnormalities and clinical pain. Therefore, classification of pain conditions like chronic low back pain, osteoarthritis, and fibromyalgia depends mostly on self report and less on objective findings like X-ray or magnetic resonance imaging (MRI) changes. However, recent advances in structural and functional brain imaging have identified brain abnormalities in chronic pain conditions that can be used for illness classification...
January 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/28141634/neuroimaging-mechanisms-in-pain-from-discovery-to-translation
#13
Irene Tracey
For over twenty years neuroimaging has made a substantial impact on our understanding of human pain experiences within the experimental, acute and chronic setting. Functional activity that relates to the perceptual experience or its modulation, alongside structural, neurochemical and receptor changes, have given us remarkable insight to the extraordinary events that underpin human pain and its transition to or vulnerability towards chronic pain. These insights at a systems neuroscience level have largely focussed on the human brain and to a lesser extent the spinal cord; however, more recently preclinical neuroimaging using similar metrics is gathering pace...
January 30, 2017: Pain
https://www.readbyqxmd.com/read/28135659/new-insights-into-the-pathogenesis-and-treatment-of-irritable-bowel-syndrome
#14
REVIEW
Joanna Oświęcimska, Agnieszka Szymlak, Wojciech Roczniak, Katarzyna Girczys-Połedniok, Jarosław Kwiecień
Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders (FGID), characterized by abdominal pain and a change in stool form that cannot be explained by structural abnormalities. Its prevalence ranges from 9 to 23% of the worldwide population. The pathophysiology of IBS is diverse and not well understood. Biopsychosocial concept assumes that the disease is a product of psychosocial factors and altered at multiple levels of gut physiology interactions. Some aetiological factors have been identified, yet...
January 27, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/28135213/brain-activity-for-tactile-allodynia-a-longitudinal-awake-rat-functional-magnetic-resonance-imaging-study-tracking-emergence-of-neuropathic-pain
#15
Pei-Ching Chang, Maria Virginia Centeno, Daniel Procissi, Alex Baria, A Vania Apkarian
Tactile allodynia, a condition in which innocuous mechanical stimuli are perceived as painful, is a common feature of chronic pain. However, how the brain reorganizes in relation to the emergence of tactile allodynia is still largely unknown. This may stem from the fact that experiments in humans are cross-sectional in nature, whereas animal brain imaging studies typically require anaesthesia rendering the brain incapable of consciously sensing or responding to pain. In this longitudinal functional magnetic resonance imaging study in awake rats, we tracked brain activity with the development of tactile allodynia...
March 2017: Pain
https://www.readbyqxmd.com/read/28130187/overexpression-of-mir-206-ameliorates-chronic-constriction-injury-induced-neuropathic-pain-in-rats-via-the-mek-erk-pathway-by-targeting-brain-derived-neurotrophic-factor
#16
Wenbo Sun, Limin Zhang, Rui Li
Neuropathic pain is chronic pain caused by lesions or diseases of the somatosensory system and existing tolerance to currently available analgesics. MicroRNAs (miRNAs) have been widely studied in the development of neuropathic pain and neuro-inflammation resulting from nerve injury. However, the precise mechanism of miRNAs involved in neuropathic pain remains largely unknown. In the present study, we investigated the vital roles of miR-206 and its putative target gene, brain-derived neurotrophic factor (BDNF), in neuropathic pain in the rat model of chronic constriction injury (CCI)...
January 24, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28123022/tnf-%C3%AE-differentially-regulates-synaptic-plasticity-in-the-hippocampus-and-spinal-cord-by-microglia-dependent-mechanisms-after-peripheral-nerve-injury
#17
Yong Liu, Li-Jun Zhou, Jun Wang, Dai Li, Wen-Jie Ren, Jiyun Peng, Xiao Wei, Ting Xu, Wen-Jun Xin, Rui-Ping Pang, Yong-Yong Li, Zhi-Hai Qin, Madhuvika Murugan, Mark P Mattson, Long-Jun Wu, Xian-Guo Liu
: Clinical studies show that chronic pain is accompanied by memory deficits and reduction in hippocampal volume. Experimental studies show that spared nerve injury (SNI) of the sciatic nerve induces long-term potentiation (LTP) at C-fiber synapses in spinal dorsal horn, but impairs LTP in the hippocampus. The opposite changes may contribute to neuropathic pain and memory deficits, respectively. However, the cellular and molecular mechanisms underlying the functional synaptic changes are unclear...
January 25, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28116559/altered-functional-connectivity-of-amygdala-underlying-the-neuromechanism-of-migraine-pathogenesis
#18
Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Zhao Dong, Lin Ma, Shengyuan Yu
BACKGROUND: The amygdala is a large grey matter complex in the limbic system, and it may contribute in the neurolimbic pain network in migraine. However, the detailed neuromechanism remained to be elucidated. The objective of this study is to investigate the amygdala structural and functional changes in migraine and to elucidate the mechanism of neurolimbic pain-modulating in the migraine pathogenesis. METHODS: Conventional MRI, 3D structure images and resting state functional MRI were performed in 18 normal controls (NC), 18 patients with episodic migraine (EM), and 16 patients with chronic migraine (CM)...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28114184/pain-has-an-element-of-blank-a-biobehavioral-approach-to-chronicity
#19
Herta Flor
The development of acute to chronic pain is characterized by a shift from nociceptive brain circuits to those involved in emotion, motivation, cognition and learning. Psychological, psychosocial, genetic and neurobiological determinants of these evolving brain circuits are discussed and it is suggested that different concepts ofchronicity may have a common psychobiological basis. The analysis of these chronicity factors leads to the identification of psychobiological mechanisms of chronicity andmay change the classification of pain syndromes from a mainly descriptive to a mechanistic basis...
January 18, 2017: Pain
https://www.readbyqxmd.com/read/28087191/alterations-of-brain-activity-in-fibromyalgia-patients
#20
REVIEW
Passakorn Sawaddiruk, Sahattaya Paiboonworachat, Nipon Chattipakorn, Siriporn C Chattipakorn
Fibromyalgia is a chronic pain syndrome, characterized by widespread musculoskeletal pain with diffuse tenderness at multiple tender points. Despite intense investigations, the pathophysiology of fibromyalgia remains elusive. Evidence shows that it could be due to changes in either the peripheral or central nervous system (CNS). For the CNS changes, alterations in the high brain area of fibromyalgia patients have been investigated but the definite mechanisms are still unclear. Magnetic Resonance Imaging (MRI) and Functional Magnetic Resonance (fMRI) have been used to gather evidence regarding the changes of brain morphologies and activities in fibromyalgia patients...
January 10, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
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