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Cell therapy myocardial infarction

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https://www.readbyqxmd.com/read/29140809/stem-cell-therapy-for-acute-myocardial-infarction-on-the-horizon-or-still-a-dream
#1
Kenneth M Fish, Kiyotake Ishikawa, Roger J Hajjar
No abstract text is available yet for this article.
November 14, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/29138752/the-effect-of-granulocyte-colony-stimulating-factor-on-the-progression-of-atherosclerosis-in-animal-models-a-meta-analysis
#2
REVIEW
Manli Liu, Kejian Liu, Dongdong Chen, Hongzhi Chen, Kunming Sun, Xinxin Ju, Jiaojiao Lan, Yang Zhou, Weishan Wang, Lijuan Pang
Background: Atherosclerosis is a common inflammatory disease. Stem cell and endothelial progenitor cell treatments can improve cardiac function after myocardial infarction. Granulocyte colony-stimulating factor (G-CSF) is a mobilisation agent, mobilising stem cells from the bone marrow to circulation in the blood. G-CSF may constitute a treatment of atherosclerosis. We have conducted meta-analysis to evaluate the current evidence for the effect of G-CSF on the progression of atherosclerosis in animal models and to provide reference for preclinical experiments and future human clinical trials of atherosclerosis treatment...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29128115/chronic-use-of-proton-pump-inhibitors-adverse-events-and-potential-biological-mechanisms-a-translational-analysis
#3
Farid Kheloufi, Diane Frankel, Elise Kaspi, Marion Lepelley, Michel Mallaret, Quentin Boucherie, Patrice Roll, Joelle Micallef
Proton pump inhibitors (PPIs) are among the most frequently prescribed drugs. Even if PPI are usually considered as safe, there is a growing concern for a range of adverse effects of chronic PPI therapy often in the absence of appropriate indications. We propose, after a summary of renal, cardiovascular and neurological complications (dementia, chronic kidney disease, myocardial infarction and stroke), an integrative overview of the potential biological mechanisms involved. Eleven positive pharmacoepidemiological studies, mainly based on health insurance database linkage to hospital database, reported an increased risk of complications associated to PPI use and often a graded association suggesting also a possible dose-response relationship...
October 14, 2017: Thérapie
https://www.readbyqxmd.com/read/29127238/protective-effects-of-the-mechanistic-target-of-rapamycin-against-excess-iron-and-ferroptosis-in-cardiomyocytes
#4
Yuichi Baba, Jason K Higa, Briana K Shimada, Kate M Horiuchi, Tomohiro Suhara, Motoi Kobayashi, Jonathan D Woo, Hiroko Aoyagi, Karra S Marh, Hiroaki Kitaoka, Takashi Matsui
Clinical studies suggest that myocardial iron is a risk factor for left ventricular remodeling in patients after myocardial infarction (MI). Ferroptosis was recently reported as a mechanism of iron-dependent non-apoptotic cell death. However, ferroptosis in the heart is not well understood. The mechanistic target of rapamycin (mTOR) protects the heart against pathological stimuli such as ischemia. To define the role of cardiac mTOR on cell survival in iron-mediated cell death, we examined cardiomyocyte (CM) cell viability under excess iron and ferroptosis conditions...
November 10, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29127060/granulocyte-colony-stimulating-factor-and-autologous-cd133-positive-stem-cell-therapy-in-liver-cirrhosis-realistic-an-open-label-randomised-controlled-phase-2-trial
#5
Philip Noel Newsome, Richard Fox, Andrew L King, Darren Barton, Nwe-Ni Than, Joanna Moore, Christopher Corbett, Sarah Townsend, James Thomas, Kathy Guo, Diana Hull, Heather A Beard, Jacqui Thompson, Anne Atkinson, Carol Bienek, Neil McGowan, Neil Guha, John Campbell, Dan Hollyman, Deborah Stocken, Christina Yap, Stuart John Forbes
BACKGROUND: Results of small-scale studies have suggested that stem-cell therapy is safe and effective in patients with liver cirrhosis, but no adequately powered randomised controlled trials have been done. We assessed the safety and efficacy of granulocyte colony-stimulating factor (G-CSF) and haemopoietic stem-cell infusions in patients with liver cirrhosis. METHODS: This multicentre, open-label, randomised, controlled phase 2 trial was done in three UK hospitals and recruited patients with compensated liver cirrhosis and MELD scores of 11·0-15·5...
November 7, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29116020/assessment-of-safety-and-efficacy-of-mesenchymal-stromal-cell-therapy-in-preclinical-models-of-acute-myocardial-infarction-a-systematic-review-protocol
#6
Carly C Barron, Manoj M Lalu, Duncan J Stewart, Dean Fergusson, Homer Yang, David Moher, Peter Liu, David Mazer, P J Devereaux, Lauralyn McIntyre
BACKGROUND: Despite advances in treatment, acute myocardial infarction (MI) is still associated with significant morbidity and mortality, especially in patients with extensive damage and scar formation. Based on some promising preclinical studies, there is interest in the use of mesenchymal stromal cells (MSCs) to promote cardiac repair after acute MI. However, there is a need for a systematic review of this evidence to summarize the efficacy and safety of MSCs in preclinical models of MI...
November 7, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29110602/pharmacometabonomics-technique-to-identify-warfarin-response-using-nuclear-magnetic-resonance-spectroscopy
#7
Abdulkader Ahmad Bawadikji, Chin-Hoe Teh, Muhamad Ali Bin Sheikh Abdul Kader, Syed Azhar Syed Sulaiman, Baharudin Ibrahim
BACKGROUND: Warfarin, an anticoagulant medication, has prescribed regularly despite of its bleeding tendency for the prevention and/or treatment of various thromboembolic conditions, such as deep vein thrombosis, and complications associated with atrial fibrillation, and myocardial infarction, but because of its narrow therapeutic window have a lot of interactions with drugs and diet. METHOD: Warfarin relies on regular monitoring of International Normalized Ratio which is a standardized test to measure prothrombin time and appropriate dose adjustment...
November 3, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29108898/thymidine-phosphorylase-a-potential-new-target-for-treating-cardiovascular-disease
#8
REVIEW
Wei Li, Hong Yue
We recently found that thymidine phosphorylase (TYMP), also known as platelet-derived endothelial cell growth factor, plays an important role in platelet activation in vitro and thrombosis in vivo by participating in multiple signaling pathways. Platelets are a major source of TYMP. Since platelet-mediated clot formation is a key event in several fatal diseases, such as myocardial infarction, stroke and pulmonary embolism, understanding TYMP in depth may lead to uncovering novel mechanisms in the development of cardiovascular diseases...
October 20, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29106545/extracellular-vesicles-in-diagnostics-and-therapy-of-the-ischaemic-heart-position-paper-from-the-working-group-on-cellular-biology-of-the-heart-of-the-european-society-of-cardiology
#9
Joost Petrus Gerardus Sluijter, Sean Michael Davidson, Chantal Marthe Boulanger, Edit Iren Buzás, Dominique Paschalis Victor de Kleijn, Felix Benedikt Engel, Zoltán Giricz, Derek J Hausenloy, Raj Kishore, Sandrine Lecour, Jonathan Leor, Rosalinda Madonna, Cinzia Perrino, Fabrice Prunier, Susmita Sahoo, Ray Michel Schiffelers, Rainer Schulz, Linda Wilhelmina Van Laake, Kirsti Ytrehus, Péter Ferdinandy
Extracellular vesicles (EVs) - particularly exosomes and microvesicles - are attracting considerable interest in the cardiovascular field as the wide range of their functions is recognized. These capabilities include transporting regulatory molecules including different RNA species, lipids, and proteins through the extracellular space including blood and delivering these cargos to recipient cells to modify cellular activity. EVs powerfully stimulate angiogenesis, and can protect the heart against myocardial infarction...
November 2, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/29102280/reperfusion-therapy-what-s-with-the-obstructed-leaky-and-broken-capillaries
#10
REVIEW
D Neil Granger, Peter R Kvietys
Microvascular dysfunction is well established as an early and rate-determining factor in the injury response of tissues to ischemia and reperfusion (I/R). Severe endothelial cell dysfunction, which can develop without obvious morphological cell injury, is a major underlying cause of the microvascular abnormalities that accompany I/R. While I/R-induced microvascular dysfunction is manifested in different ways, two responses that have received much attention in both the experimental and clinical setting are impaired capillary perfusion (no-reflow) and endothelial barrier failure with a transition to hemorrhage...
September 21, 2017: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29101218/discovery-of-novel-small-molecule-inducers-of-heme-oxygenase-1-that-protect-human-ipsc-derived-cardiomyocytes-from-oxidative-stress
#11
R Jason Kirby, Daniela B Divlianska, Kanupriya Whig, Nadezda Bryan, Camilo J Morfa, Ada Koo, Becky L Hood, Kevin H Nguyen, Patrick Maloney, Satayamaheshwar Peddibhotla, E Hampton Sessions, Paul M Hershberger, Layton H Smith, Siobhan Malany
Oxidative injury to cardiomyocytes plays a critical role in cardiac pathogenesis following myocardial infarction. Transplantation of stem cell-derived cardiomyocytes has recently progressed as a novel treatment to repair damaged cardiac tissue but its efficacy has been limited by poor survival of transplanted cells due to oxidative stress in the post-transplantation environment. Identification of small molecules that activate cardioprotective pathways to prevent oxidative damage and increase survival of stem cells post-transplantation is therefore of great interest to improve the efficacy of stem cell therapies...
November 3, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29096705/a-brief-review-the-therapeutic-potential-of-bone-marrow-mesenchymal-stem-cells-in-myocardial-infarction
#12
REVIEW
Chi Miao, Mingming Lei, Weina Hu, Shuo Han, Qi Wang
Myocardial infarction (MI) results in dysfunction and irreversible loss of cardiomyocytes and is among the most serious health threats today. Bone marrow mesenchymal stem cells (BMSCs), with their capacity for multidirectional differentiation, low immunogenicity, and high portability, can serve as ideal seed cells in cardiovascular disease therapy. In this review, we examine recent literature concerning the application of BMSCs for the treatment of MI and consider the following aspects: activity of transplanted cells, migration and homing of BMSCs, immunomodulatory and anti-inflammatory effects of BMSCs, anti-fibrotic activity of BMSCs, the role of BMSCs in angiogenesis, and differentiation of BMSCs into cardiomyocyte-like cells and endothelial cells...
November 2, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29093370/-development-of-targeted-pharmacotherapy-for-cardiovascular-disease
#13
Yasufumi Katanasaka
 Heart and cardiovascular diseases are the leading causes of death in the world. Heart failure (HF) in particular is becoming a serious widespread medical issue, especially following various stresses such as myocardial infarction and hemodynamic overload. One pathological cardiac change in HF is left ventricular hypertrophy (LVH). LVH is associated with increased risk for HF; however, no drug therapy for LVH has yet been developed. During the development of LVH, gene expression is altered in cardiomyocytes through transcription factors, co-activators, and histone modifications...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/29078809/mesenchymal-stem-cells-for-cardiac-repair-are-the-actors-ready-for-the-clinical-scenario
#14
REVIEW
Santiago Roura, Carolina Gálvez-Montón, Clémentine Mirabel, Joaquim Vives, Antoni Bayes-Genis
For years, sufficient progress has been made in treating heart failure following myocardial infarction; however, the social and economic burdens and the costs to world health systems remain high. Moreover, treatment advances have not resolved the underlying problem of functional heart tissue loss. In this field of research, for years we have actively explored innovative biotherapies for cardiac repair. Here, we present a general, critical overview of our experience in using mesenchymal stem cells, derived from cardiac adipose tissue and umbilical cord blood, in a variety of cell therapy and tissue engineering approaches...
October 27, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29075204/human-cardiomyocyte-progenitor-cells-in-co-culture-with-rat-cardiomyocytes-form-a-pro-arrhythmic-substrate-evidence-for-two-different-arrhythmogenic-mechanisms
#15
Nicoline W Smit, Lucia Cócera Ortega, Anna M D Végh, Veronique M F Meijborg, Anke M Smits, Mischa Klerk, Anke J M Tijsen, Hanno L Tan, Marie-José H T Goumans, Gerard J J Boink, Ruben Coronel
Background: Cardiomyocyte progenitor cells (CMPCs) are a promising cell source for regenerative cell therapy to improve cardiac function after myocardial infarction. However, it is unknown whether undifferentiated CMPCs have arrhythmogenic risks. We investigate whether undifferentiated, regionally applied, human fetal CMPCs form a pro-arrhythmic substrate in co-culture with neonatal rat ventricular myocytes (NRVMs). Method: Unipolar extracellular electrograms, derived from micro-electrode arrays (8 × 8 electrodes) containing monolayers of NRVMs (control), or co-cultures of NRVMs and locally seeded CMPCs were used to determine conduction velocity and the incidence of tachy-arrhythmias...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29069583/shrna-interference-of-nlrp3-inflammasome-alleviate-ischemia-reperfusion-induced-myocardial-damage-through-autophagy-activation
#16
Zhu Meng, Mei-Yan Song, Chuan-Fang Li, Jia-Qi Zhao
Myocardial ischemia-reperfusion (I/R) injury always occur during the recovery of myocardial blood supply with high morbidity and mortality. Although, various therapeutic schedules were applied in clinic, there are real problems that have to be resolved on curative effect. Nod-like receptor protein 3 (NLRP3) inflammasome has moderation effects on cellular damage and inflammatory reaction after I/R injury. Our research aims to investigate a more effective approach to restrain the activation of NLRP3 inflammasome in treating myocardial I/R injury...
October 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29058205/monocyte-mediated-drug-delivery-systems-for-the-treatment-of-cardiovascular-diseases
#17
REVIEW
Gil Aizik, Etty Grad, Gershon Golomb
Major advances have been achieved in understanding the mechanisms and risk factors leading to cardiovascular disorders and consequently developing new therapies. A strong inflammatory response occurs with a substantial recruitment of innate immunity cells in atherosclerosis, myocardial infarction, and restenosis. Monocytes and macrophages are key players in the healing process that ensues following injury. In the inflamed arterial wall, monocytes, and monocyte-derived macrophages have specific functions in the initiation and resolution of inflammation, principally through phagocytosis, and the release of inflammatory cytokines and reactive oxygen species...
October 20, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29057537/cpg-oligodeoxynucleotide-preconditioning-improves-cardiac-function-after-myocardial-infarction-via-modulation-of-energy-metabolism-and-angiogenesis
#18
Deng-Cheng Zhou, Yong-Hui Su, Fu-Qing Jiang, Jing-Bo Xia, Hai-Yan Wu, Zao-Shang Chang, Wen-Tao Peng, Guo-Hua Song, Kyu-Sang Park, Soo-Ki Kim, Dong-Qing Cai, Li Zheng, Xu-Feng Qi
Unmethylated CpG oligodeoxynucleotide (CpG-ODN), a Toll-like receptor 9 (TLR9) ligand, has been shown to protect against myocardial ischemia/reperfusion injury. However, the potential effects of CpG-ODN on myocardial infarction (MI) induced by persistent ischemia remains unclear. Here, we investigated whether and how CpG-ODN preconditioning protects against MI in mice. C57BL/6 mice were treated with CpG-ODN by i.p. injection 2 hours prior to MI induction, and cardiac function and histology were analyzed two weeks after MI...
October 23, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29054138/mdivi-1-protects-human-w8b2-cardiac-stem-cells-from-oxidative-stress-and-simulated-ischemia-reperfusion-injury
#19
Ayeshah A Rosdah, Simon T Bond, Priyadharshini Sivakumaran, Ashfaqul Hoque, Jonathan S Oakhill, Brian G Drew, Lea Md Delbridge, Shiang Yong Lim
Cardiac stem cell (CSC) therapy is a promising approach to treat ischemic heart disease. However, the poor survival of transplanted stem cells in the ischemic myocardium has been a major impediment in achieving an effective cell-based therapy against myocardial infarction. Inhibiting mitochondrial fission has been shown to promote survival of several cell types. However, the role of mitochondrial morphology in survival of human CSC remains unknown. In this study, we investigated whether Mdivi-1, an inhibitor of mitochondrial fission protein Drp1, can improve survival of a novel population of human W8B2+ CSCs in hydrogen peroxide-induced oxidative stress and simulated ischemia-reperfusion injury models...
October 20, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/29053673/a-chronic-cardiac-ischemia-model-in-swine-using-an-ameroid-constrictor
#20
Karen J Keeran, Kenneth R Jeffries, Arthur D Zetts, Joni Taylor, Shawn Kozlov, Timothy J Hunt
Cardiovascular disease remains the number one cause of mortality in the United States. There are numerous approaches to treating these diseases, but regardless of the approach, an in vivo model is needed to test each treatment. The pig is one of the most used large animal models for cardiovascular disease. Its heart is very similar in anatomy and function to that of a human. The ameroid placement technique creates an ischemic area of the heart, which has many useful applications in studying myocardial infarction...
October 9, 2017: Journal of Visualized Experiments: JoVE
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