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Biodegradable polymer stent

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https://www.readbyqxmd.com/read/29437036/five-year-outcome-of-a-randomized-trial-comparing-second-generation-drug-eluting-stents-using-either-biodegradable-polymer-or-durable-polymer-the-nobori-biolimus-eluting-versus-xience-promus-everolimus-eluting-stent-trial-next
#1
Masahiro Natsuaki, Ken Kozuma, Takeshi Morimoto, Kazushige Kadota, Toshiya Muramatsu, Yoshihisa Nakagawa, Takashi Akasaka, Keiichi Igarashi Hanaoka, Kengo Tanabe, Yoshihiro Morino, Hideo Nishikawa, Takeshi Kimura
No abstract text is available yet for this article.
February 13, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29413303/safety-and-efficacy-of-drug-eluting-stents-combining-biodegradable-polymers-with-ultrathin-stent-platforms
#2
EDITORIAL
Juan F Iglesias, Thomas Pilgrim
No abstract text is available yet for this article.
January 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29400652/comparison-between-two-biodegradable-polymer-based-sirolimus-eluting-stents-with-differing-drug-elution-and-polymer-absorption-kinetics-two-year-clinical-outcomes-of-the-panda-iii-trial
#3
Juan Wang, Changdong Guan, Shubin Qiao, Xuebin Cao, Lei Qin, Yi Li, Zhanquan Li, Xueqi Li, Jiansong Yuan, Runlin Gao, Bo Xu
AIMS: In PANDA III trial, the novel poly-lactide-co-glycolide polymer-based BuMA sirolimus-eluting stent (SES) was non-inferior to the polylactide polymer-based Excel SES for the primary endpoint of 1-year target lesion failure (TLF), with a lower incidence of stent thrombosis. We sought to investigate whether the effectiveness profile of BuMA SES, with more rapid drug elution and polymer absorption kinetics, would persist at 2 years. METHODS AND RESULTS: A total of 2,348 patients (mean age, 61...
February 6, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29382011/biodegradable-polymer-drug-eluting-stents-versus-first-generation-durable-polymer-drug-eluting-stents-a-systematic-review-and-meta-analysis-of-12-randomized-controlled-trials
#4
Pravesh Kumar Bundhun, Manish Pursun, Feng Huang
BACKGROUND: Even if drug-eluting stents (DES) showed beneficial effects in patients with coronary artery diseases (CADs), limitations have been observed with the first-generation durable polymer DES (DP-DES). Recently, biodegradable polymer DES (BP-DES) have been approved to be used as an alternative to DP-DES, with potential benefits. We aimed to systematically compare BP-DES with the first-generation DP-DES using a large number of randomized patients. METHODS: Electronic databases were searched for randomized controlled trials (RCTs) comparing BP-DES with first-generation DP-DES...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29368394/complex-coronary-bifurcation-treatment-by-a-novel-stenting-technique-bench-test-fluid-dynamic-study-and-clinical-outcomes
#5
Gianluca Rigatelli, Marco Zuin, Fabio Dell'Avvocata, Dobrin Vassilev, Ramesh Daggubati, Thach Nguyen, Minh Trí Nhân Nguyễn, Nicolas Foin
OBJECTIVES: We assess the mid-term outcomes of ultrathin biodegradable polymer double stenting using a very minimal crushing (Nano-Crush) technique in large complex coronary bifurcation. BACKGROUND: Complex bifurcations have been suggested to be better approached by a planned double stent technique. METHODS: Two hundred and five consecutive patients (107 males and 98 females) referred for large complex coronary bifurcation percutaneous coronary interventions were enrolled...
January 25, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29338896/novel-bioabsorbable-polymer-and-polymer-free-metallic-drug-eluting-stents
#6
REVIEW
Jason Nogic, Liam M McCormick, Rohin Francis, Nitesh Nerlekar, Catherine Jaworski, Nick E J West, Adam J Brown
The introduction of drug-eluting stents (DES) significantly reduced angiographic restenosis and the clinical need for revascularization following percutaneous coronary intervention. However, concerns remain regarding the long-term safety and efficacy of DES. The use of durable polymers for drug elution that have limited biocompatibility is thought to contribute toward DES failure, by promoting an adverse local inflammatory response and vascular toxicity. Biodegradable polymer and polymer-free metallic stents represent two novel technological solutions to this challenging clinical problem...
January 12, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29335827/satisfactory-arterial-repair-1%C3%A2-year-after-ultrathin-strut-biodegradable-polymer-sirolimus-eluting-stent-implantation-an-angioscopic-observation
#7
Takayuki Ishihara, Masaki Awata, Osamu Iida, Masashi Fujita, Masaharu Masuda, Shin Okamoto, Kiyonori Nanto, Takashi Kanda, Takuya Tsujimura, Masaaki Uematsu, Toshiaki Mano
The ultrathin strut biodegradable polymer sirolimus-eluting stent (Orsiro, O-SES) exhibits satisfactory clinical outcomes. However, no report to date has documented the intravascular status of artery repair after O-SES implantation. We examined 5 O-SES placed in 4 patients (age 65 ± 12 years, male 75%) presenting with stable angina pectoris due to de novo lesions in native coronary arteries. Coronary angioscopy was performed immediately after percutaneous coronary intervention and 1 year later. Angioscopic images were analyzed to determine the following: (1) dominant grade of neointimal coverage (NIC) over the stent; (2) maximum yellow plaque grade; and (3) existence of thrombus...
January 15, 2018: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/29322619/randomized-comparison-of-novel-biodegradable-polymer-and-durable-polymer-coated-cobalt-chromium-sirolimus-eluting-stents-three-year-outcomes-of-the-i-love-it-2-trial
#8
Lei Song, Jing Li, Changdong Guan, Quanmin Jing, Shuzheng Lu, Lixia Yang, Kai Xu, Yuejin Yang, Bo Xu, Yaling Han
OBJECTIVES: We aimed to compare the long-term outcomes of the novel biodegradable polymer cobalt-chromium sirolimus-eluting stent (BP-SES) versus the durable polymer sirolimus-eluting stent (DP-SES) in the I-LOVE-IT2 trial. BACKGROUNDS: Comparisons of the long-term safety and efficiency of the BP-DES versus the DP-DES are limited. METHODS: A total of 2,737 patients eligible for coronary stenting were randomized to the BP-SES or DP-SES group at a 2:1 ratio...
January 11, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29316284/a-propensity-score-matched-comparison-of-biodegradable-polymer-versus-second-generation-durable-polymer-drug-eluting-stents-in-a-real-world-population
#9
Ying Jiao Zhao, Monica Teng, Ai Leng Khoo, Rajiv Ananthakrishna, Tiong Cheng Yeo, Boon Peng Lim, Joshua P Loh, Mark Y Chan
AIMS: The safety and efficacy of BP-DES compared to second-generation DP-DES remain unclear in the real-world setting. We compared the clinical outcomes of biodegradable polymer drug-eluting stents (BP-DES) with second-generation durable polymer drug-eluting stents (DP-DES) in an all-comer percutaneous coronary intervention (PCI) registry. METHODS/RESULTS: The study included a cohort of 1,065 patients treated with either BP-DES or DP-DES from January 2009 through October 2015...
January 8, 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29300853/vascular-response-to-percutaneous-coronary-intervention-with-biodegradable-polymer-vs-new-generation-durable-polymer-drug-eluting-stents-a-meta-analysis-of-optical-coherence-tomography-imaging-trials
#10
Salvatore Cassese, Erion Xhepa, Gjin Ndrepepa, Sebastian Kufner, Roisin Colleran, Daniele Giacoppo, Tobias Koppara, Nader Mankerious, Robert A Byrne, Karl-Ludwig Laugwitz, Heribert Schunkert, Massimiliano Fusaro, Adnan Kastrati, Michael Joner
Aims: Whether biodegradable-polymer drug-eluting stents (BP-DES) induce a vascular response at follow-up more favourable than that of new-generation durable-polymer drug-eluting stents (DP-DES) remains controversial. We sought to evaluate the vascular response to percutaneous coronary intervention (PCI) with BP-DES vs. new-generation DP-DES as assessed by optical coherence tomography (OCT) imaging at follow-up. Methods and results: We undertook a meta-analysis of aggregate data by searching electronic scientific databases for investigations of PCI-patients receiving BP-DES vs...
January 2, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29284158/optimized-polymer-coating-for-magnesium-alloy-based-bioresorbable-scaffolds-for-long-lasting-drug-release-and-corrosion-resistance
#11
Wei Xu, Kai Yagoshi, Yuki Koga, Makoto Sasaki, Takuro Niidome
Magnesium (Mg) alloy-based bioresorbable scaffolds (BRSs) are attracting interest as next-generation stents. However, because medical Mg alloy materials degrade relatively quickly in physiological media, surface corrosion protection via biodegradable polymer coatings is important for clinical applications. Herein, the influence of biodegradable polymer coatings on the BRS corrosion was investigated. First, elution of the drug sirolimus (SRL) from various biodegradable polymers was estimated, including poly(d,l-lactic acid) (PDLLA), poly(d,l-lactic acid-co-ε-caprolactone) (PLCL) and poly(ε-caprolactone) (PCL)...
December 19, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29281608/a-new-generation-of-drug-eluting-stents-indications-and-outcomes-of-bioresorbable-vascular-scaffolds
#12
REVIEW
Ron Waksman
Drug-eluting stents (DES) are increasingly being used as a less invasive alternative to coronary artery bypass grafting. Early generation DES had durable polymers that provided acceptable efficacy outcomes but had high rates of stent thrombosis leading to myocardial infarction and death. Second-generation DES have improved outcomes by reducing stent thrombosis and recurrent stenosis. Newer DES with biodegradable polymers have similar efficacy as second-generation DES, but have higher rates of stent thrombosis...
December 2017: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/29246909/serial-assessment-of-strut-coverage-of-biodegradable-polymer-drug-eluting-stent-at-1-2-and-3-months-after-stent-implantation-by-optical-frequency-domain-imaging-the-discovery-1to3-study-evaluation-with-ofdi-of-strut-coverage-of-terumo-new-drug-eluting-stent
#13
Bernard Chevalier, Pieter C Smits, Didier Carrié, Julinda Mehilli, Ad J Van Boven, Evelyn Regar, Fadi J Sawaya, Daniel Chamié, Adriaan O Kraaijeveld, Thomas Hovasse, Georgios J Vlachojannis
BACKGROUND: To assess the vessel-healing pattern of Ultimaster drug-eluting stent using optical frequency domain imaging. Our hypothesis is that biodegradable polymer-based drug-eluting technology allows complete very early strut coverage. METHODS AND RESULTS: The DISCOVERY 1TO3 study (Evaluation With OFDI of Strut Coverage of Terumo New Drug Eluting Stent With Biodegradable Polymer at 1, 2, and 3 Months) is a prospective, single-arm, multicenter study. A total of 60 patients with multivessel disease requiring staged procedure at 1 month were treated with Ultimaster...
December 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29243907/strategy-of-metal-polymer-composite-stent-to-accelerate-biodegradation-of-iron-based-biomaterials
#14
Yongli Qi, Haiping Qi, Yao He, Wenjiao Lin, Pei-Ze Li, Li Qin, Yiwen Hu, Liping Chen, Qingsong Liu, Hongtao Sun, Qiong Liu, Gui Zhang, Shuquan Cui, Jun Hu, Lin Yu, Deyuan Zhang, Jiandong Ding
The new principle and technique to tune biodegradation rates of biomaterials is one of keys to development of regenerative medicine and next-generation biomaterials. Biodegradable stents are new-generation medical devices applied in percutaneous coronary intervention etc. Recently, both corrodible metals and degradable polymers have drawn much attention in biodegradable stents or scaffolds. It is, however, a dilemma to achieve good mechanical properties and appropriate degradation profiles. Herein, we put forward a metal-polymer composite strategy to achieve both...
December 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29221958/a-comparison-of-the-ultrathin-orsiro-hybrid-sirolimus-eluting-stent-with-contemporary-drug-eluting-stents-a-meta-analysis-of-randomized-controlled-trials
#15
Michael J Lipinski, Brian J Forrestal, Micaela Iantorno, Rebecca Torguson, Ron Waksman
BACKGROUND: Recent studies suggest the Orsiro sirolimus-eluting stent (O-SES), which has ultrathin struts with a biodegradable sirolimus-eluting polymer coating, performed better than contemporary drug-eluting stents (DES). We performed a meta-analysis to compare clinical outcomes for all randomized controlled trials (RCTs) of O-SES vs contemporary DES. METHODS/MATERIALS: PubMed, Cochrane CENTRAL, and meeting abstracts were searched for all RCTs comparing O-SES with contemporary DES...
November 21, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29214779/effectiveness-and-safety-of-biolimus-a9%C3%A2-eluting-stent-in-patients-with-acute-coronary-syndrome-a-multicenter-observational-study-beauty-study
#16
Keun Ho Park, Myung Ho Jeong, Young Joon Hong, Youngkeun Ahn, Hyun Kuk Kim, Young Yub Koh, Doo Il Kim, Sang Wook Kim, Weon Kim, Seung Woon Rha, Jay Young Rhew, Jong Seon Park, Hun Sik Park, Jang Ho Bae, Jang Whan Bae, Seok Kyu Oh, Sung Yun Lee, Seung Wook Lee, Jae Hwan Lee, Sang Yeob Lim, Jang Hyun Cho, Kwang Soo Cha, Jai Keon Chae, Seung Ho Hur, Sun Ho Hwang, Jin Yong Hwang
PURPOSE: This study sought to determine the 1-year clinical effectiveness and safety of a biodegradable, polymer-containing Biolimus A9™-eluting stent (BES) in Korean patients with acute coronary syndrome (ACS). MATERIALS AND METHODS: A total of 1000 ACS patients with 1251 lesions who underwent implantation of BESs at 22 centers in Korea were enrolled between May 2011 and July 2013. We assessed major adverse cardiac events (MACE) defined as the composite of cardiac death, non-fatal myocardial infarction (MI), and clinical-driven target vessel revascularization at 12 months...
January 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29205157/a-comparison-of-an-ultrathin-strut-biodegradable-polymer-sirolimus-eluting-stent-with-a-durable-polymer-everolimus-eluting-stent-for-patients-with-acute-stsegment-elevation-myocardial-infarction-undergoing-primary-percutaneous-coronary-intervention-rationale
#17
Juan F Iglesias, Olivier Muller, Serge Zaugg, Marco Roffi, David J Kurz, André Vuilliomenet, Daniel Weilenmann, Christoph Kaiser, Maxime Tapponnier, Dik Heg, Marco Valgimigli, Eric Eeckhout, Peter Jüni, Stephan Windecker, Thomas Pilgrim
AIMS: A novel ultrathin-strut biodegradable polymer sirolimus-eluting stent (Orsiro™, Biotronik, Bülach, Switzerland; BP-SES) was shown to be superior to a thin-strut durable polymer everolimus-eluting stent (Xience™ Xpedition/Alpine, Abbott Vascular, Santa Clara, USA; DP-EES) with respect to the primary endpoint of target lesion failure (TLF) at 12 months in the prespecified subgroup of patients with ST-segment elevation myocardial infarction (STEMI) included in the BIOSCIENCE trial...
December 5, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29198920/impact-of-post-dilatation-on-longitudinal-stent-elongation-an-in-vitro-study
#18
Takuya Sumi, Hideki Ishii, Akihito Tanaka, Susumu Suzuki, Hiroki Kojima, Naoki Iwakawa, Toshijiro Aoki, Kenshi Hirayama, Takayuki Mitsuda, Kazuhiro Harada, Yosuke Negishi, Tomoyuki Ota, Kenji Kada, Toyoaki Murohara
OBJECTIVES: To evaluate whether balloon inflation for post-dilatation causes longitudinal stent deformation (LSD). METHODS AND RESULTS: Two stents, sized 2.5mm×28mm and 3.5mm×28mm (Nobori®, biodegradable polymer biolimus-eluting stent; Ultimaster®, biodegradable polymer sirolimus-eluting stent; Terumo Co., Tokyo, Japan), were deployed at nominal pressure in straight and tapered silicon vessel models. Then, post-dilatation was performed in two ways: dilatation from the distal (D-P group) or proximal (P-D group) side of the stent...
November 30, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/29174500/long-term-results-of-a-sirolimus-eluting-stent-with-biodegradable-polymer-rapstrom%C3%A2-in-de-novo-coronary-stenoses
#19
Filippo Figini, Chaman Nadish Manjunath, Balaji Chandra Srinivas, Kanvar Sarat Sadananda, Madhu Sreedharan, Louie Fischer, Ramakrishna Pillai, Kiron Varghese, Ajay K Gopal, Chamarajnagar Mahadevappa Nagesh, Imad Sheiban
OBJECTIVES: To report long-term results of a novel sirolimus-eluting stent with biodegradable polymer BACKGROUND: Newer generation drug-eluting stents are characterized by thin struts, improved platform design and highly biocompatible polymer carrying the antiproliferative drug. The RapstromTM stent, sharing these features, showed promising outcomes in preclinical models and in a first-in-man trial. METHODS: The present study is a multicenter, non-randomized post-market registry, including patients with de novo coronary artery disease treated with implantation of one or more Rapstrom stents...
October 7, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29166720/-long-term-safety-and-efficacy-of-a-novel-abluminal-groove-filled-biodegradable-polymer-sirolimus-eluting-stent-for-the-treatment-of-coronary-de-novo-lesions
#20
C J Li, B Xu, C D Guan, R L Gao
Objective: To compare the long term safety and efficacy of the novel abluminal groove-filled biodegradable polymer sirolimus-eluting stent(Firehawk stent) and permanent polymer coating everolimus eluting stent(Xience V stent) for the treatment of coronary de novo lesions. Methods: This prospective, multi-center, non-inferiority, randomized control trial(TARGETⅠ trial) was performed between August 2010 and April 2011, a total of 460 patients with primary, de novo, single vessel and single coronary lesion from 16 medical centers were enrolled...
November 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
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