keyword
MENU ▼
Read by QxMD icon Read
search

Biodegradable polymer stent

keyword
https://www.readbyqxmd.com/read/28322012/3d-printed-multidrug-eluting-stent-from-graphene-nanoplatelet-doped-biodegradable-polymer-composite
#1
Santosh K Misra, Fatemeh Ostadhossein, Ramya Babu, Joseph Kus, Divya Tankasala, Andre Sutrisno, Kathleen A Walsh, Corinne R Bromfield, Dipanjan Pan
Patients with percutaneous coronary intervention generally receive either bare metal stents or drug-eluting stents to restore the normal blood flow. However, due to the lack of stent production with an individual patient in mind, the same level of effectiveness may not be possible in treating two different clinical scenarios. This study introduces for the first time the feasibility of a patient-specific stenting process constructed from direct 3D segmentation of medical images using direct 3D printing of biodegradable polymer-graphene composite with dual drug incorporation...
March 21, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28318138/safety-and-efficacy-of-6-month-versus-12-month-dual-antiplatelet-therapy-in-patients-after-implantation-of-multiple-biodegradable-polymer-coated-sirolimus-eluting-coronary-stents-insight-from-the-i-love-it-2-trial
#2
Jing Qi, Yi Li, Jing Li, Quanmin Jing, Kai Xu, Chuanyu Gao, Likun Ma, Zhi Zhang, Bo Xu, Yaling Han
OBJECTIVE: This study sought to compare the clinical outcomes of 6-month versus 12-month dual antiplatelet therapy (DAPT) in patients receiving multiple biodegradable polymer-coated sirolimus-eluting stents (BP-SES) implants. BACKGROUND: The clinical outcomes for patients who undergo multiple BP-SES implantation with different DAPT durations are uncertain. METHODS: In the I-LOVE-IT 2 trial, 907 patients treated with multiple BP-SES (total stent number ≥2) were assigned to receive 6-month (n = 440) or 12-month (n = 467) DAPT...
March 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28302466/bioflow-iii-satellite-one-year-clinical-outcomes-of-diabetic-patients-treated-with-a-biodegradable-polymer-sirolimus-eluting-stent-and-comprehensive-medical-surveillance
#3
Ran Kornowski, Ariel Roguin, Haim Danenberg, Hana Vaknin Assa, Eitan Abergel, Eliezer Rozenbaum, Victor Guetta, Uri Landes, Refat Jabara, Amnon Merdler, Amit Segev, Morris Mosseri, Abid Assali
BACKGROUND: Drug-eluting stents with biodegradable polymer might be particularly useful in diabetic patients who are at increased risk for target lesion/target vessel revascularization. We therefore aimed at assessing the safety and performance of a biodegradable polymer sirolimus-eluting stent (BP-SES) in combination with comprehensive optimal medical therapy following coronary interventions. METHODS: This prospective, multicenter registry was conducted at six centers in Israel...
February 21, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28284499/the-optimal-discontinuation-of-dual-antiplatelet-therapy-in-patients-undergoing-percutaneous-coronary-intervention-with-drug-eluting-stents-a-meta-analysis-of-randomized-trials
#4
Wei Wang, Jing Liu, Jingxue Fang, Yang Liu, Tong An, Meijuan Zou, Gang Cheng
BACKGROUND: Current guidelines recommend prolonged dual antiplatelet therapy (DAPT) for patients with drug-eluting stents (DES) implantation. Nevertheless, optimal discontinuation of DAPT remains a controversy. We performed a meta-analysis of all randomized controlled trials (RCTs) that evaluate optimal discontinuation of DAPT in patients undergoing percutaneous coronary intervention (PCI) with DES. METHODS: We searched electronic databases including PubMed, Cochrane Library, EMBASE and ClinicalTrials...
May 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28279315/biodegradable-polymer-drug-eluting-stents-can-a-class-effect-be-assumed
#5
EDITORIAL
Jeffrey W Moses, Vivian G Ng
No abstract text is available yet for this article.
March 13, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28279314/meta-analysis-of-randomized-clinical-trials-comparing-biodegradable-polymer-drug-eluting-stent-to-second-generation-durable-polymer-drug-eluting-stents
#6
Georges El-Hayek, Sripal Bangalore, Abel Casso Dominguez, Chandan Devireddy, Wissam Jaber, Gautam Kumar, Kreton Mavromatis, Jacqueline Tamis-Holland, Habib Samady
OBJECTIVES: The authors sought to perform a meta-analysis of randomized clinical trials (RCTs) comparing the safety and efficacy of biodegradable polymer drug-eluting stents (BP-DES) to second-generation durable polymer drug-eluting stents (DP-DES). BACKGROUND: Prior meta-analyses have established the superiority of BP-DES over bare-metal stents and first-generation DP-DES; however, their advantage compared with second-generation DP-DES remains controversial. METHODS: The authors searched PubMed and Scopus databases for RCTs comparing BP-DES to the second-generation DP-DES...
March 13, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28220461/new-generation-coronary-stents-current-data-and-future-directions
#7
REVIEW
Ankur Kalra, Hasan Rehman, Sahil Khera, Braghadheeswar Thyagarajan, Deepak L Bhatt, Neal S Kleiman, Robert W Yeh
PURPOSE OF REVIEW: Drug-eluting stents are the mainstay in the treatment of coronary artery disease using percutaneous coronary intervention. Innovations developed to overcome the limitations of prior generations of stents include biodegradable polymer stents, drug-eluting stents without a polymer, and bioabsorbable scaffolds. Our review briefly discusses the clinical profiles of first- and second-generation coronary stents, and provides an up-to-date overview of design, technology, and clinical safety and efficacy profiles of newer generation coronary stents discussing the relevant clinical trials in this rapidly evolving area of interventional cardiology...
March 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/28197826/safety-and-efficacy-of-a-novel-abluminal-groove-filled-biodegradable-polymer-sirolimus-eluting-stent
#8
Jinzhou Zhu, Huizhu Liu, Haipo Cui, Zhirong Tang, Chengli Song, Ruiyan Zhang
Late stent thrombosis (LST) following drug-eluting stent (DES) implantation in patients with coronary artery disease (CAD) is often associated with delayed vascular healing, resulting from vascular inflammation and hypersensitivity to durable polymers and drugs. Therefore, DES design, materials, and coatings have been technologically revolutionized. Herein, we designed a novel abluminal groove-filled biodegradable polymer sirolimus-eluting stent (AGF-BP-SES), with a sirolimus content of only about one-third of traditional DES...
March 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28185168/polymer-free-drug-coated-coronary-stents-in-patients-with-stable-coronary-artery-disease-at-high-bleeding-risk
#9
REVIEW
Hemang B Panchal, Ramesh Daggubati, David Zhao, Sunil V Rao, Timir Paul
PURPOSE OF REVIEW: Patients with stable coronary artery disease (CAD) and a high risk of bleeding are not ideal candidates for a polymer-based drug-eluting stent (DES) because it requires 6-12 months of dual antiplatelet therapy (DAPT) following percutaneous coronary intervention (PCI). The purpose of this review is to assess the angiographic and clinical outcomes of polymer-free drug-coated stents (PF-DCS) in stable CAD patients with a high bleeding risk. RECENT FINDINGS: Several randomized controlled trials (RCTs) have compared angiographic and clinical outcomes of PF-DCS with bare-metal stents (BMS), permanent polymer (PP)-DES, or biodegradable polymer (BP)-DES...
February 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28184401/biodegradable-vascular-stents-with-high-tensile-and-compressive-strength-a-novel-strategy-for-applying-monofilaments-via-solid-state-drawing-and-shaped-annealing-processes
#10
Seung Hyuk Im, Chang Yong Kim, Youngmee Jung, Yangsoo Jang, Soo Hyun Kim
Monofilaments such as those consisting of polyamide (PA), polydioxanone (PDS), and poly(vinylidene fluoride) (PVDF), have been commonly used in various industries. However, most are non-biodegradable, which is unfavorable for many biomedical applications. Although biodegradable polymers offer significant benefits, they are still limited by their weak mechanical properties, which is an obstacle for use as a biomaterial that requires high strength. To overcome the current limitations of biodegradable monofilaments, a novel solid-state drawing (SSD) process was designed to significantly improve the mechanical properties of both PA and poly(l-lactic acid) (PLLA) monofilaments in this study...
February 10, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28183306/third-generation-drug-eluting-stent-des-with-biodegradable-polymer-in-diabetic-patients-5%C3%A2-years-follow-up
#11
Marcus Wiemer, Sinisa Stoikovic, Alexander Samol, Zisis Dimitriadis, Juan M Ruiz-Nodar, Ralf Birkemeyer, Jacques Monsegu, Gérard Finet, David Hildick-Smith, Damras Tresukosol, Enrique Garcia Novo, Jacques J Koolen, Emanuele Barbato, Gian Battista Danzi
OBJECTIVE: To report the long-term safety and efficacy data of a third generation drug eluting stent (DES) with biodegradable polymer in the complex patient population of diabetes mellitus after a follow-up period of 5 years. BACKGROUND: After percutaneous coronary intervention patients with diabetes mellitus are under higher risk of death, restenosis and stent thrombosis (ST) compared to non-diabetic patients. METHODS: In 126 centers worldwide 3067 patients were enrolled in the NOBORI 2 registry, 888 patients suffered from diabetes mellitus (DM), 213 of them (14%) being insulin dependent (IDDM)...
February 10, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28165708/preparation-characterization-and-mechanism-for-biodegradable-and-biocompatible-polyurethane-shape-memory-elastomers
#12
Yu-Chun Chien, Wei-Tsung Chuang, U-Ser Jeng, Shan-Hui Hsu
Thermally induced shape memory is an attractive feature of certain functional materials. Among the shape memory polymers, shape memory elastomers (SMEs) especially those with biodegradability have great potential in the biomedical field. In this study, we prepared waterborne biodegradable polyurethane SME based on poly(ε-caprolactone) (PCL) oligodiol and poly(l-lactic acid) (PLLA) oligodiol as the mixed soft segments. The ratio of the soft segments in polyurethanes was optimized for shape memory behavior. The thermally induced shape memory mechanism of the series of polyurethanes was clarified using differential scanning calorimeter (DSC), X-ray diffraction (XRD), and small-angle X-ray scattering (SAXS)...
February 6, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28140661/fabrication-and-characterization-of-shape-memory-polymers-based-bioabsorbable-biomedical-drug-eluting-stent
#13
Vratika C Sonawane, Mahesh P More, Abhijeet P Pandey, Pravin O Patil, Prashant K Deshmukh
Present investigation deals with, tacrolimus eluting, self-expandable, biodegradable stent fabricated by solvent casting method. The design was based on shape memory polymers, which possess the ability to memorize temporary shape that can substantially differ from their initial permanent shape. A set of biodegradable polymers blend was used such as poly-lactic acid (PLA) and poly-l-glycolic acid (PLGA) to study the shape memory effect of polymer. The prepared stent was assessed for various parameters like Scanning Electron Microscopy (SEM), In-vitro and Ex vivo expansion, Drug content, In-vitro drug release, Haemocompatibility, Differential Scanning Calorimetry (DSC), Fourier Transform Infrared spectroscopy (FTIR), and Textural Characterization...
January 31, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28120558/nobori-biolimus-eluting-stents-versus-resolute-zotarolimus-eluting-stents-in-patients-undergoing-coronary-intervention-a-propensity-score-matching
#14
Ayman Tantawy, Chul Min Ahn, Dong Ho Shin, Jung Sun Kim, Byeong Keuk Kim, Young Guk Ko, Donghoon Choi, Yangsoo Jang, Meong Ki Hong
PURPOSE: To compare the 1-year outcomes of a durable polymer Zotarolimus-eluting stent (ZES) versus a biodegradable polymer Biolimus-eluting stent (BES) in patients undergoing percutaneous coronary intervention. MATERIALS AND METHODS: A total of 2083 patients from 2 different registries, 1125 treated with BES in NOBORI registry and 858 received ZES in CONSTANT registry were included in this study. Clinical outcomes were compared with the use of propensity score matching (PSM)...
March 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28112473/efficacy-and-safety-of-a-biodegradable-polymer-cobalt-chromium-sirolimus-eluting-stent-excel2-in-treating-de-novo-coronary-artery-disease-a-pooled-analysis-of-the-credit-ii-and-credit-iii-trials
#15
Geng Wang, Heyang Wang, Bo Xu, Yuejin Yang, Zhiming Yang, Hui Li, Zheng Zhang, Haichang Wang, Lixia Yang, Yaling Han
BACKGROUND: The safety and efficacy of the second-generation biodegradable polymer Cobalt-Chromium sirolimus-eluting stent (EXCEL2) in daily clinical practice remains unknown. Additionally, to meet the China Food and Drug Administration requirements, we conducted an objective performance criterion study from the CREDIT II and CREDIT III trials. METHODS: CREDIT II was a randomized trial comparing the EXCEL2 versus EXCEL stent in patients with up to 2 de novo coronary lesions...
January 23, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28109874/comparison-of-durable-polymer-zotarolimus-eluting-and-biodegradable-polymer-biolimus-eluting-coronary-stents-in-patients-with-coronary-artery-disease-3-year-clinical-outcomes-in-the-randomized-sort-out-vi-trial
#16
Bent Raungaard, Evald H Christiansen, Hans Erik Bøtker, Henrik S Hansen, Jan Ravkilde, Leif Thuesen, Jens Aarøe, Anton B Villadsen, Christian J Terkelsen, Lars R Krusell, Michael Maeng, Steen D Kristensen, Karsten T Veien, Knud N Hansen, Anders Junker, Morten Madsen, Søren L Andersen, Svend E Jensen, Lisette O Jensen
OBJECTIVES: The authors sought to compare the safety and efficacy of the biocompatible durable-polymer zotarolimus-eluting stent with the biodegradable-polymer biolimus-eluting stent in unselected coronary patients. BACKGROUND: Biodegradable-polymer biolimus-eluting stents are superior to first-generation durable-polymer drug-eluting stents in long-term randomized all-comer trials. Long-term data comparing them to second-generation durable-polymer drug-eluting stents are lacking...
February 13, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28109057/comparison-of-two-biodegradable-polymer-based-sirolimus-eluting-stents-with-varying-elution-and-absorption-kinetics-in-patients-with-acute-myocardial-infarction-a-subgroup-analysis-of-the-panda-iii-trial
#17
Changdong Guan, Bo Xu, Shubin Qiao, Lei Qin, Yi Li, Zhanquan Li, Yong Guo, Zhongwei Sun, Lei Song, Runlin Gao
BACKGROUND: Implantation of early-generation metallic drug-eluting stents (DES) in patients with acute myocardial infarction (AMI) is associated with poor vessel wall healing. Use of biodegradable polymer (BP) DES might improve safety outcomes; however, the impact of varying drug elution and polymer absorption kinetics of BP-DES on clinical outcomes in the AMI population is unknown. METHODS: This subgroup analysis of the randomized PANDA III trial included 732 patients (366 in each group) presenting with recent (<1 month) AMI...
January 21, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28105994/angiographic-outcomes-of-orsiro-biodegradable-polymer-sirolimus-eluting-stents-and-resolute-integrity-durable-polymer-zotarolimus-eluting-stents-results-of-the-orient-trial
#18
Si-Hyuck Kang, Woo-Young Chung, Joo Myung Lee, Jin-Joo Park, Chang-Hwan Yoon, Jung-Won Suh, Young-Seok Cho, Joon-Hyung Doh, Jin Man Cho, Jang-Whan Bae, Tae-Jin Youn, In-Ho Chae
AIMS: We performed a randomised controlled open-label non-inferiority trial to compare angiographic outcomes between the ultra-thin strut, biodegradable hybrid polymer Orsiro sirolimus-eluting stent (O-SES) and the durable biocompatible polymer Resolute Integrity zotarolimus-eluting stent (R-ZES). METHODS AND RESULTS: A total of 372 patients planned to undergo percutaneous coronary revascularisation were randomly assigned 2:1 to treatment with O-SES or R-ZES (250 and 122 patients, respectively)...
January 20, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28104206/randomized-multicenter-trial-investigating%C3%A2-angiographic-outcomes-of%C3%A2-hybrid-sirolimus-eluting-stents-with%C3%A2-biodegradable-polymer-compared-with%C3%A2-everolimus-eluting-stents-with-durable%C3%A2-polymer-in-chronic-total-occlusions-the-prison-iv-trial
#19
Koen Teeuwen, René J van der Schaaf, Tom Adriaenssens, Jacques J Koolen, Pieter C Smits, José P S Henriques, Paul H M J Vermeersch, R Melvyn Tjon Joe Gin, Bastiaan E Schölzel, Johannes C Kelder, Jan G P Tijssen, Pierfrancesco Agostoni, Maarten J Suttorp
OBJECTIVES: The aim of this study was to investigate the efficacy and safety of the hybrid ultrathin-strut sirolimus-eluting stent (SES) with biodegradable polymer compared with the thin-strut everolimus-eluting stent (EES) with durable polymer in successfully recanalized chronic total occlusions (CTOs). BACKGROUND: The introduction of drug-eluting stents revolutionized the treatment of CTOs. However, limited data are available on new-generation drug-eluting stents with biodegradable polymer in CTOs...
January 23, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28096181/long-term-8-10%C3%A2-years-outcomes-after-biodegradable-polymer-coated-biolimus-eluting-stent-implantation
#20
Masanobu Ohya, Shunsuke Kubo, Akimune Kuwayama, Katsuya Miura, Takenobu Shimada, Hidewo Amano, Yusuke Hyodo, Suguru Otsuru, Seiji Habara, Takeshi Tada, Hiroyuki Tanaka, Yasushi Fuku, Harumi Katoh, Tsuyoshi Goto, Kazushige Kadota
OBJECTIVE: Efficacy and safety data on biodegradable polymer-coated biolimus-eluting stent (BP-BES) are currently limited to 5 years. We evaluated longer term (8-10 years) clinical and angiographic outcomes after BP-BES implantation. METHODS: Between 2005 and 2008, 243 patients (301 lesions) underwent BP-BES implantation. The primary clinical outcome measure was defined as any target lesion revascularisation (TLR). Absolute serial angiographic studies without any concomitant TLR within 2 years after the procedure were performed in 55 patients (65 lesions) at postprocedure, mid-term (within 1 year), late term (between 1 and 2 years) and very late term (beyond 2 years)...
January 17, 2017: Heart: Official Journal of the British Cardiac Society
keyword
keyword
58904
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"