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Biodegradable polymer stent

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https://www.readbyqxmd.com/read/29651802/three-months-optical-coherence-tomography-analysis-of-a-biodegradable-polymer-sirolimus-eluting-stent
#1
Еvgeny Kretov, Ivan Naryshkin, Vitaly Baystrukov, Igor Grazhdankin, Aleksei Prokhorikhin, Dmitry Zubarev, Alexey Biryukov, Vladimir Verin, Andrey Boykov, Dastan Malaev, Evgeny Pokushalov, Alexander Romanov, Martin W Bergmann
OBJECTIVE: We aimed to assess early neointimal healing by optical coherence tomography (OCT) 3 months after implantation of the ultrathin Orsiro® sirolimus-eluting stent with biodegradable polymer. BACKGROUND: New generations of drug-eluting stents with biodegradable polymer have been developed to avoid the continued vascular irritation of durable polymers. METHODS: In this prospective, open-label study, 34 patients received an Orsiro® sirolimus-eluting stent with biodegradable polymer...
April 12, 2018: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/29629708/dipyridamole-loaded-biodegradable-pla-nanoplatforms-as-coatings-for-cardiovascular-stents
#2
Veroniki Bakola, Varvara Karagkiozaki, Aikatherini-Rafailia Tsiapla, Foteini Pappa, Ioannis Moutsios, Eleni Pavlidou, Stergious Logothetidis
Cardiovascular Stents are commonly used for the treatment of Cardiovascular Diseases (CVDs) that in developed societies, are the most frequent causes of mortality and morbidity. Recent years, thorough research and development of Drug Eluting Stents (DES) has been done, with emphasis on coronary stenting to avoid the most common complication, the in-stent thrombosis. Dipyridamole (DPM) is a medication that inhibits blood clot formation. Drug Delivery Nanoplatforms consisting of biodegradable polymers can be fabricated via Electrospinning Deposition, known for its cost-effective and versatile advantages, that produces fibrous scaffolds able of sustainable and controllable drug release...
April 9, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29622449/one-year-clinical-outcome-of-biodegradable-polymer-sirolimus-eluting-stent-in-all-comers-population-insight-from-the-ulisse-registry-ultimaster-italian-multicenter-all-comers-stent-registry
#3
Cosmo Godino, Alessandro Beneduce, Giuseppe Ferrante, Alfonso Ielasi, Andrea Carlo Pivato, Mauro Chiarito, Alberto Cappelletti, Giulia Perfetti, Valeria Magni, Eugenio Prati, Stefania Falcone, Adele Pierri, Stefano De Martini, Matteo Montorfano, Rosario Parisi, David Rutigliano, Nicola Locuratolo, Angelo Anzuini, Maurizio Tespilli, Alberto Margonato, Alberto Benassi, Carlo Briguori, Franco Fabbiocchi, Bernhard Reimers, Antonio Bartorelli, Antonio Colombo
BACKGROUND: This study was designed to confirm in a large population of unselected patients the promising results of Ultimaster® biodegradable polymer sirolimus-eluting stent (BP-SES) already shown in previous trial. METHODS: ULISSE is an observational, multicenter, national registry evaluating all patients undergoing PCI with the Ultimaster® BP-SES. Incidence of 1-year TLF (cardiac death or target vessel MI or clinically indicated TLR) was the primary endpoint...
June 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29619983/acute-thrombogenicity-of-fluoropolymer-coated-versus-biodegradable-and-polymer-free-stents
#4
Sho Torii, Qi Cheng, Hiroyoshi Mori, Michael J Lipinski, Eduardo Acampado, Laura E L Perkins, Syed F Hossainy, Stephen D Pacetti, Frank D Kolodgie, Renu Virmani, Aloke V Finn
AIMS: Durable-fluoropolymer coated everolimus-eluting stents (FP-EES) have shown lower rates of stent thrombosis (ST) versus bare-metal stents (BMS) and 1st-generation bioabsorbable-polymer (BP) DES. However, the specific role of the FP in thromboresistance has not been explored. METHODS AND RESULTS: A total of 57 stents were assessed in 3 separate ex-vivo swine arterio-venous shunt-model experiments [1st-shunt-experiment, custom-made fluoropolymer-coated BMS (FP-only) vs...
April 3, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29607135/ultrathin-strut-biodegradable-polymer-sirolimus-eluting-stents-being-wary-or-going-with-the-flow
#5
EDITORIAL
Salvatore Cassese, Anna Lena Lahmann, Michael Joner
No abstract text is available yet for this article.
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29606869/propylthiouracil-coated-biodegradable-polymer-inhibited-neointimal-formation-and-enhanced-re-endothelialization-after-vascular-injury
#6
Shang-Hung Chang, Cheng-Hung Lee, Yung-Hsin Yeh, Shih-Jung Liu, Chao-Jan Wang, Ming-Yi Hsu, Wei-Jan Chen
Background: The drug-eluting stent is a standard approach for the treatment of coronary artery disease. Propylthiouracil (PTU), an antithyroid drug, has been proven to suppress neointimal formation after balloon injury. Materials and methods: This study used a biodegradable polymer coating with PTU to test its effects on platelet function, re-endothelialization, and neointimal formation after vascular injury. Electrospinning was used to fabricate hybrid stents and generate PTU-loaded nanofibers...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29589672/the-synergy-stent-in-high-bleeding-risk-patients-why-design-matters
#7
Mauro Chiarito, Davide Cao, Francesco Cannata, Cristina Panico, Bernhard Reimers, Giulio G Stefanini
Antithrombotic management after percutaneous coronary intervention is based on dual antiplatelet therapy (DAPT), that has unequivocally shown to reduce the risk of recurrent ischemic events at cost of an important risk of bleeding. In order to balance ischemic and bleeding risks, DAPT duration should be based on patients and lesions features as well as stent type. Based on these considerations, patients at high bleeding risk (HBR) undergoing PCI represent a challenging subgroup. The Synergy stent (Boston Scientific, Marlborough, MA, USA) is a new-generation everolimus-eluting stent with a biodegradable polymer coating, presenting several features that have the potential to reduce acute and long-term thrombogenicity and the subsequent need for DAPT...
March 28, 2018: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/29578542/a-tailorable-in-situ-light-activated-biodegradable-vascular-scaffold
#8
Mazen S Albaghdadi, Jian Yang, Jessica H Brown, Neel A Mansukhani, Guillermo A Ameer, Melina R Kibbe
Biodegradable vascular scaffolds (BVS) are novel treatments for obstructive atherosclerotic cardiovascular disease that have been developed to overcome the limitations of traditional metallic drug-eluting stents (DES). The mechanical properties of bioabsorbable polymers used for the production of novel BVS are a key consideration for the clinical translation of this emerging technology. Herein, we describe the engineering of an in situ light-activated vascular scaffold (ILVS) comprised of a biodegradable citric acid-based elastomeric polymer, referred to as methacrylated poly-diol citrate (mPDC), and a diazeniumdiolate chitosan nitric oxide donor (chitoNO)...
April 2017: Advanced materials technologies
https://www.readbyqxmd.com/read/29568667/effect-of-nonionic-surfactants-in-release-media-on-accelerated-in-vitro-release-profile-of-sirolimus-eluting-stents-with-biodegradable-polymeric-coating
#9
Ami Raval, Pratap Bahadur, Ankur Raval
It is a well-known fact that sirolimus (SRL) undergoes degradation process via hydrolysis in aqueous media, leading to incorrect assessment of drug amount and thus release characteristics of formulations. The main objective of the present study was to evaluate the effect of nonionic surfactants in media on in-vitro release profiles for sirolimus eluting stents (SES) coated with biodegradable polymeric matrix. Phosphate buffer and acetate buffer incorporating nonionic surfactants with varying concentrations were examined for adequate solubility and stability (by RP-HPLC)...
February 2018: Journal of Pharmaceutical Analysis
https://www.readbyqxmd.com/read/29544956/randomised-comparison-of-vascular-response-to-biodegradable-polymer-sirolimus-eluting-and-permanent-polymer-everolimus-eluting-stents-an-optical-coherence-tomography-study
#10
Tobias Koppara, Tomohisa Tada, Erion Xhepa, Sebastian Kufner, Robert A Byrne, Tareq Ibrahim, Karl-Ludwig Laugwitz, Adnan Kastrati, Michael Joner
BACKGROUND: Drug-eluting stents with biodegradable polymer coatings have shown promising outcomes in randomised studies. METHODS: We compared neointimal healing patterns including strut coverage and assessed neointimal maturity using a novel algorithm in coronary lesions treated with sirolimus-eluting stents with biodegradable polymer coating (BP-SES) or everolimus eluting stents with permanent polymer coating (PP-EES) using optical coherence tomography after 6months...
May 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29537375/outcomes-of-patients-treated-with-ultrathin-strut-biodegradable-polymer-sirolimus-eluting-stents-versus-fluoropolymer-based-everolimus-eluting-stents-a-meta-analysis-of-randomized-trials
#11
Salvatore Cassese, Gjin Ndrepepa, Robert A Byrne, Sebastian Kufner, Anna Lena Lahmann, Nader Mankerious, Erion Xhepa, Karl-Ludwig Laugwitz, Heribert Schunkert, Massimiliano Fusaro, Adnan Kastrati, Michael Joner
AIMS: The ultrathin strut biodegradable-polymer sirolimus-eluting stent (SES) is a new-generation drug-eluting stent (DES) developed to improve the percutaneous treatment of patients with coronary artery disease. Here, we sought to investigate whether the performance of ultrathin strut biodegradable-polymer SES is superior to that of the benchmark thin-strut fluoropolymer-based everolimus-eluting stent (EES). METHODS AND RESULTS: We undertook a study-level meta-analysis of trials, in which patients receiving percutaneous coronary intervention (PCI) were randomly assigned to either SES or EES...
March 13, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29493880/efficacy-and-safety-of-a-second-generation-biodegradable-polymer-sirolimus-eluting-stent-one-year-results-of-the-credit-2-trial
#12
Kai Xu, Yaling Han, Bo Xu, Yuejin Yang, Geng Wang, Hui Li, Yong Sun, Ling Tao, Haichang Wang, Zuyi Yuan, Liu Huiliang, Jinghua Liu, Yongping Jia, Genshan Ma, Guosheng Fu, Xiaodong Li, Shuren Li, Shouli Wang, Kui Pu
AIMS: We performed a multicenter, randomized controlled trial to determine the noninferiority of a novel biodegradable-polymer drug-eluting stent (BP-DES), the EXCEL 2 stent, to the first generation BP-DES, the EXCEL stent. METHODS AND RESULTS: Patients (n=419) scheduled to undergo percutaneous coronary intervention (PCI) were randomized to receive either the EXCEL 2 stent (n=208) or the EXCEL stent(n=211) from 15 Chinese centers. At 9 months, primary endpoint in-stent late loss (LL) difference was -0...
March 1, 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29471933/safety-and-effectiveness-of-second-generation-drug-eluting-stents-in-patients-with-left-main-coronary-artery-disease
#13
Pil Hyung Lee, Osung Kwon, Jung-Min Ahn, Cheol Hyun Lee, Do-Yoon Kang, Jung-Bok Lee, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Seong-Wook Park, Duk-Woo Park, Seung-Jung Park
BACKGROUND: Limited data are available on the relative performances between different types of drug-eluting stents (DES) for obstructive left main coronary artery disease (LMCAD). OBJECTIVES: This study sought to compare effectiveness and safety profiles of various second-generation DES for LMCAD in real-world clinical practice. METHODS: Among 4,470 patients in 3, multicenter, prospective registries (IRIS-DES [Interventional Cardiology Research Incorporation Society-Drug-Eluting Stents] registry, the IRIS-MAIN [Interventional Cardiology Research Incorporation Society-Left MAIN Revascularization] registry, and the PRECOMBAT [PREmier of Randomized COMparison of Bypass Surgery versus AngioplasTy Using Drug-Eluting Stent in Patients with Left Main Coronary Artery Disease] study) treated between July 2007 and July 2015, the authors identified 2,692 patients with significant LMCAD who received second-generation DES; 1,254 with cobalt-chromium everolimus-eluting stents (CoCr-EES), 232 with biodegradable polymer biolimus-eluting stents (BP-BES), 616 with platinum-chromium EES (PtCr-EES), and 590 with Resolute zotarolimus-eluting stent (Re-ZES)...
February 27, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29470998/evaluation-of-a-new-design-of-antireflux-biodegradable-ureteral-stent-in-animal-model
#14
Federico Soria, Esther Morcillo, Alvaro Serrano, Alberto Budia, Inmaculada Fernández, Tomás Fernández-Aparicio, Francisco M Sanchez-Margallo
OBJECTIVES: The purpose is to determine the effects in urinary tract of a new antireflux biodegradable ureteral stent. MATERIAL AND METHODS: Thirty six ureters belonging to 24 pigs were used. The study began with an endoscopic, nephrosonographic and fluoroscopic assessment. Three study groups of n=12 ureters were then specified. In Group I, a biodegradable antireflux stent (BDG-ARS) was inserted in the right ureter of 12 pigs. Group II was comprised by the left ureter of the same animals, in which a double pigtail stent was placed for 6 weeks...
February 19, 2018: Urology
https://www.readbyqxmd.com/read/29464786/polymer-free-drug-eluting-stents-for-coronary-artery-disease
#15
REVIEW
Moritz Baquet, David Jochheim, Julinda Mehilli
Polymer-free drug-eluting stents (PF-DES) were designed with the expectation of avoiding late restenosis and thrombosis related to the polymer used in traditional DES platforms. Furthermore, due to similarities with bare metal stents after drug elution, PF-DES has been considered as particularly suitable for patients at high bleeding risk. A variety of PF-DES platforms have been clinically tested. Despite their theoretical advantages, PF platforms showed comparable clinical outcomes with modern permanent- or biodegradable polymer-based DES up to 5 years after implantation...
February 20, 2018: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/29454724/-silent-diabetes-and-clinical-outcome-after-treatment-with-contemporary-drug-eluting-stents-the-bio-resort-silent-diabetes-study
#16
Clemens von Birgelen, Marlies M Kok, Naveed Sattar, Paolo Zocca, Cees Doelman, Gert D Kant, Marije M Löwik, Liefke C van der Heijden, Hanim Sen, K Gert van Houwelingen, Martin G Stoel, J Hans W Louwerenburg, Marc Hartmann, Frits H A F de Man, Gerard C M Linssen, Carine J M Doggen, Kenneth Tandjung
OBJECTIVES: This study sought to assess the prevalence and clinical impact of silent diabetes and pre-diabetes in "nondiabetic" percutaneous coronary intervention (PCI) all-comers. BACKGROUND: Patients with undetected and thus untreated (silent) diabetes may have higher event risks after PCI with contemporary drug-eluting stents (DES). METHODS: The BIO-RESORT Silent Diabetes study, performed at Thoraxcentrum Twente, is a substudy of the randomized multicenter BIO-RESORT (BIOdegradable Polymer and DuRable Polymer Drug-eluting Stents in an All COmeRs PopulaTion) trial (NCT01674803)...
March 12, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29437036/five-year-outcome-of-a-randomized-trial-comparing-second-generation-drug-eluting-stents-using-either-biodegradable-polymer-or-durable-polymer-the-nobori-biolimus-eluting-versus-xience-promus-everolimus-eluting-stent-trial-next
#17
Masahiro Natsuaki, Ken Kozuma, Takeshi Morimoto, Kazushige Kadota, Toshiya Muramatsu, Yoshihisa Nakagawa, Takashi Akasaka, Keiichi Igarashi Hanaoka, Kengo Tanabe, Yoshihiro Morino, Hideo Nishikawa, Takeshi Kimura
No abstract text is available yet for this article.
February 13, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29413303/safety-and-efficacy-of-drug-eluting-stents-combining-biodegradable-polymers-with-ultrathin-stent-platforms
#18
EDITORIAL
Juan F Iglesias, Thomas Pilgrim
No abstract text is available yet for this article.
January 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29400652/comparison-between-two-biodegradable-polymer-based-sirolimus-eluting-stents-with-differing-drug-elution-and-polymer-absorption-kinetics-two-year-clinical-outcomes-of-the-panda-iii-trial
#19
Juan Wang, Changdong Guan, Shubin Qiao, Xuebin Cao, Lei Qin, Yi Li, Zhanquan Li, Xueqi Li, Jiansong Yuan, Runlin Gao, Bo Xu
AIMS: In PANDA III trial, the novel poly-lactide-co-glycolide polymer-based BuMA sirolimus-eluting stent (SES) was non-inferior to the polylactide polymer-based Excel SES for the primary endpoint of 1-year target lesion failure (TLF), with a lower incidence of stent thrombosis. We sought to investigate whether the effectiveness profile of BuMA SES, with more rapid drug elution and polymer absorption kinetics, would persist at 2 years. METHODS AND RESULTS: A total of 2,348 patients (mean age, 61...
February 6, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29382011/biodegradable-polymer-drug-eluting-stents-versus-first-generation-durable-polymer-drug-eluting-stents-a-systematic-review-and-meta-analysis-of-12-randomized-controlled-trials
#20
Pravesh Kumar Bundhun, Manish Pursun, Feng Huang
BACKGROUND: Even if drug-eluting stents (DES) showed beneficial effects in patients with coronary artery diseases (CADs), limitations have been observed with the first-generation durable polymer DES (DP-DES). Recently, biodegradable polymer DES (BP-DES) have been approved to be used as an alternative to DP-DES, with potential benefits. We aimed to systematically compare BP-DES with the first-generation DP-DES using a large number of randomized patients. METHODS: Electronic databases were searched for randomized controlled trials (RCTs) comparing BP-DES with first-generation DP-DES...
November 2017: Medicine (Baltimore)
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