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Biodegradable polymer stent

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https://www.readbyqxmd.com/read/29924777/-vascular-stents-approaches-used-to-increase-their-clinical-efficacy
#1
K A Kuznetsov, M V Khar'kova, A A Karpenko, P P Laktionov
Using stents for endovascular restoration of blood flow made a revolution in vascular surgery, however, despite numerous variants of stents presented on the pharmacological market, there are no stents which would completely solve the problem of restenosis in the area of stent placement. In order to decrease growth of the neointima of the stented portions of vessels, stents coated with cytostatic and cytotoxic agents were worked out. To optimize the rate of drug release it was suggested to apply them in a mixture with biodegradable or biostable polymers...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29885127/-progress-in-research-drug-eluting-stents-drug-looding-and-drug-release-kinetics
#2
Caixia Song, Chao Zhou, Haijun Zhang
Drug eluting stents are one of the main devices of coronary intervention, which play a therapeutic role through the combination of medical devices. Drug is an important part of the drug eluting stents. The loading method, the type of carrier, drug and carrier interaction and the preparation process of the drug directly affect the drugs release kinetics characteristics of the device and the final treatment. According to the characteristics of the drug coating, drug coated stents can be divided into non-degradable polymers drug coated stents, biodegradable polymers drug coated stents and polymer-free drug eluting stents...
May 30, 2018: Zhongguo Yi Liao Qi Xie za Zhi, Chinese Journal of Medical Instrumentation
https://www.readbyqxmd.com/read/29873191/cost-effectiveness-analysis-of-biodegradable-polymer-versus-durable-polymer-drug-eluting-stents-incorporating-real-world-evidence
#3
Monica Teng, Ying Jiao Zhao, Ai Leng Khoo, Rajiv Ananthakrishna, Tiong Cheng Yeo, Boon Peng Lim, Mark Y Chan, Joshua P Loh
AIM: Compared with second-generation durable polymer drug-eluting stents (DP-DES), the cost-effectiveness of biodegradable polymer drug-eluting stents (BP-DES) remains unclear in the real-world setting. We assessed the cost-effectiveness of BP-DES in patients with coronary artery disease undergoing percutaneous coronary intervention (PCI). METHODS: We developed a decision-analytic model to compare the cost-effectiveness of BP-DES to DP-DES over one year and five years from healthcare payer perspective...
June 5, 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29812907/modified-magnesium-hydroxide-nanoparticles-inhibits-the-inflammatory-response-to-biodegradable-poly-lactide-co-glycolide-plga-implants
#4
Eugene Lih, Chang Hun Kum, Wooram Park, So Young Chun, Youngjin Cho, Yoon Ki Joung, Kwang-Sook Park, Young Joon Hong, Dong June Ahn, Byung-Soo Kim, Tae Gyun Kwon, Myung Ho Jeong, Jeffrey A Hubbell, Dong Keun Han
Biodegradable polymers have been extensively used in biomedical applications, ranging from regenerative medicine to medical devices. However, the acidic byproducts resulting from degradation can generate vigorous inflammatory reactions, often leading to clinical failure. Here we present an approach to prevent acid-induced inflammatory responses associated with biodegradable polymers, here poly(lactide-co-glycolide), by using oligo(lactide)-grafted magnesium hydroxide (Mg(OH)2) nanoparticles, which neutralize the acidic environment...
May 29, 2018: ACS Nano
https://www.readbyqxmd.com/read/29798778/comparison-of-a-novel-biodegradable-polymer-sirolimus-eluting-stent-with-a-durable-polymer-everolimus-eluting-stent-5-year-outcomes-of-the-randomized-bioflow-ii-trial
#5
Thierry Lefèvre, Michael Haude, Franz-Josef Neumann, Karl Stangl, Carsten Skurk, Ton Slagboom, Manel Sabaté, Javier Goicolea, Paul Barragan, Stéphane Cook, Jean-Christophe Macia, Stephan Windecker
OBJECTIVES: The authors aimed to compare long-term data of an ultrathin cobalt-chromium stent with passive silicon carbide coating and an active biodegradable polymer that releases sirolimus (O-SES) (Orsiro, BIOTRONIK, Bülach, Switzerland) with the durable polymer-based Xience Prime everolimus-eluting stent (X-EES) (Abbott Vascular, Santa Clara, California). BACKGROUND: Biodegradable polymer stents have been developed aiming to overcome long-term detrimental effects of durable polymer stents, ultimately leaving a bare-metal stent in the vessel...
May 28, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29798765/biodegradable-polymer-drug-eluting-stent-platforms-the-importance-of-long-term-outcomes
#6
EDITORIAL
Michael A Kutcher
No abstract text is available yet for this article.
May 28, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29790480/two-year-clinical-outcome-of-all-comers-treated-with-three-highly-dissimilar-contemporary-coronary-drug-eluting-stents-in-the-randomised-bio-resort-trial
#7
Marlies M Kok, Paolo Zocca, Rosaly A Buiten, Peter W Danse, Carl E Schotborgh, Martijn Scholte, Marc Hartmann, Martin G Stoel, Gert van Houwelingen, Gerard C M Linssen, Carine J M Doggen, Clemens von Birgelen
AIMS: The aim of the study was to evaluate the two-year clinical outcome of all-comer trial participants who were treated with two very different thin-strut biodegradable polymer versus thin-strut durable polymer drug-eluting stents (DES). Prolonged clinical outcome after discontinuation of dual antiplatelet therapy is of particular interest, given the highly dissimilar polymer types, amount, distribution, and degradation speed of both biodegradable polymer DES. METHODS AND RESULTS: The BIO-RESORT trial (NCT01674803) randomly assigned 3,514 patients to treatment with biodegradable polymer SYNERGY everolimus-eluting stents (EES) or Orsiro sirolimus-eluting stents (SES), or durable polymer Resolute Integrity zotarolimus-eluting stents (ZES)...
May 23, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29788263/temporal-course-of-vascular-healing-and-neoatherosclerosis-after-implantation-of-durable-or-biodegradable-polymer-drug-eluting-stents
#8
Giulio Guagliumi, Kunihiro Shimamura, Vasile Sirbu, Roberto Garbo, Giacomo Boccuzzi, Angelina Vassileva, Orazio Valsecchi, Luigi Fiocca, Paolo Canova, Francesco Colombo, Gabriel Tensol Rodriguez Pereira, Daisuke Nakamura, Guilherme F Attizzani, Alberto Cereda, Keisuke Satogami, Leonardo De Luca, Francesco Saia, Davide Capodanno
Aims: Delayed healing and endothelial dysfunction may occur with drug-eluting stents (DES), promoting accelerated infiltration of lipids in the neointima and development of neoatherosclerosis (NA). Pathology data suggest durable polymer (DP) of DES to play a major role in this process. Whether biodegradable polymer (BP) may address these issues is uncertain. We compared in vivo vessel healing and NA of current generation BP- or DP-DES using serial optical coherence tomography (OCT) assessments...
May 19, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29770422/biodegradable-toughened-nanohybrid-shape-memory-polymer-for-smart-biomedical-applications
#9
Arpan Biswas, Akhand Pratap Singh, Dipak Rana, Vinod K Aswal, Pralay Maiti
A polyurethane nanohybrid has been prepared through the in situ polymerization of an aliphatic diisocyanate, ester polyol and a chain extender in the presence of two-dimensional platelets. Polymerization within the platelet galleries helps to intercalate, generate diverse nanostructure and improve the nano to macro scale self-assembly, which leads to a significant enhancement in the toughness and thermal stability of the nanohybrid in comparison to pure polyurethane. The extensive interactions, the reason for property enhancement, between nanoplatelets and polymer chains are revealed through spectroscopic measurements and thermal studies...
May 17, 2018: Nanoscale
https://www.readbyqxmd.com/read/29760284/unprotected-left-main-coronary-artery-disease-outcomes-of-treatment-with-second-generation-drug-eluting-stents-insight-from-the-fails-2-study
#10
Umberto Barbero, Rahim Kanji, Enrico Cerrato, Roberto Di Summa, Federico Conrotto, Hiroyoshi Kawamoto, Giuseppe Biondi-Zoccai, Sebastiano Gili, Fabrizio Ugo, Mario Iannaccone, Marco Gagliardi, Michele De Benedictis, Baldassarre Doronzo, Ferdinando Varbella, Maurizio D'Amico, Claudio Moretti, Antonio Colombo, Javier Escaned, Fabrizio D'Ascenzo
OBJECTIVE: To evaluate the outcome of patients undergoing PCI for unprotected left main coronary artery (ULMCA) disease with different drug-eluting stent (DES) types. BACKGROUND: Published literature suggests that second-generation DES options have differing vascular responses and outcomes, but there is a paucity of data in real-life patients in the LM setting. METHODS: This is a retrospective, multicenter study, including patients treated with a second-generation DES for ULMCA disease between 2007 and 2015...
May 15, 2018: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29724350/efficacy-over-time-with-drug-eluting-stents-in-saphenous-vein-graft-lesions
#11
Roisin Colleran, Sebastian Kufner, Julinda Mehilli, Christian Rosenbeiger, Stefanie Schüpke, Petra Hoppmann, Michael Joner, Nader Mankerious, Massimiliano Fusaro, Salvatore Cassese, Mohamed Abdel-Wahab, Franz-Josef Neumann, Gert Richardt, Tareq Ibrahim, Heribert Schunkert, Karl-Ludwig Laugwitz, Adnan Kastrati, Robert A Byrne
BACKGROUND: In the ISAR-CABG (Is Drug-Eluting-Stenting Associated with Improved Results in Coronary Artery Bypass Grafts?) trial, clinical outcomes at 1 year in patients undergoing treatment of saphenous vein graft lesions were superior with drug-eluting stents (DES) versus bare-metal stents. OBJECTIVES: The authors compared outcomes between treatment groups at 5 years. METHODS: Patients were randomized (1:1:1:3) to receive DES (either permanent-polymer paclitaxel-eluting stents, permanent-polymer sirolimus-eluting stents, or biodegradable-polymer sirolimus-eluting stents) or bare-metal stents...
May 8, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29704312/self-expandable-tubular-collagen-implants
#12
Luuk R M Versteegden, Marja Ter Meer, Roger M L M Lomme, J Adam van der Vliet, Leo J Schultze Kool, Toin H van Kuppevelt, Willeke F Daamen
Collagen has been extensively used as a biomaterial, yet for tubular organ repair, synthetic polymers or metals (e.g., stents) are typically used. In this study, we report a novel type of tubular implant solely consisting of type I collagen, suitable to self-expand in case of minimal invasive implantation. Potential benefits of this collagen scaffold over conventional materials include improved endothelialization, biodegradation over time, and possibilities to add bioactive components to the scaffold, such as anticoagulants...
April 28, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29687605/shape-memory-properties-and-enzymatic-degradability-of-poly-%C3%AE%C2%B5-caprolactone-based-polyurethane-urea-containing-phenylalanine-derived-chain-extender
#13
Rong Wang, Fanjun Zhang, Weiwei Lin, Wenkai Liu, Jiehua Li, Feng Luo, Yaning Wang, Hong Tan
Biodegradable shape memory polymers are promising biomaterials for minimally invasive surgical procedures. Herein, a series of linear biodegradable shape memory poly(ε-caprolactone) (PCL)-based polyurethane ureas (PUUs) containing a novel phenylalanine-derived chain extender is synthesized. The phenylalanine-derived chain extender, phenylalanine-hexamethylenediamine-phenylalanine (PHP), contains two chymotrypsin cleaving sites to enhance the enzymatic degradation of PUUs. The degradation rate, the crystallinity, and mechanical properties of PUUs are tailored by the content of PHP...
June 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29651802/three-months-optical-coherence-tomography-analysis-of-a-biodegradable-polymer-sirolimus-eluting-stent
#14
Еvgeny Kretov, Ivan Naryshkin, Vitaly Baystrukov, Igor Grazhdankin, Aleksei Prokhorikhin, Dmitry Zubarev, Alexey Biryukov, Vladimir Verin, Andrey Boykov, Dastan Malaev, Evgeny Pokushalov, Alexander Romanov, Martin W Bergmann
OBJECTIVE: We aimed to assess early neointimal healing by optical coherence tomography (OCT) 3 months after implantation of the ultrathin Orsiro® sirolimus-eluting stent with biodegradable polymer. BACKGROUND: New generations of drug-eluting stents with biodegradable polymer have been developed to avoid the continued vascular irritation of durable polymers. METHODS: In this prospective, open-label study, 34 patients received an Orsiro® sirolimus-eluting stent with biodegradable polymer...
April 12, 2018: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/29629708/dipyridamole-loaded-biodegradable-pla-nanoplatforms-as-coatings-for-cardiovascular-stents
#15
V Bakola, V Karagkiozaki, A R Tsiapla, F Pappa, I Moutsios, E Pavlidou, S Logothetidis
Cardiovascular stents are commonly used for the treatment of cardiovascular diseases that in developed societies are the most frequent causes of mortality and morbidity. In recent years, thorough research and development of drug-eluting stents has been done, with emphasis on coronary stenting to avoid the most common complication, in-stent thrombosis. Dipyridamole (DPM) is a medication that inhibits blood clot formation. Drug delivery nanoplatforms consisting of biodegradable polymers can be fabricated via electrospinning deposition, known for its cost-effective and versatile advantages, that produces fibrous scaffolds that are able to sustain and control drug release...
July 6, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29622449/one-year-clinical-outcome-of-biodegradable-polymer-sirolimus-eluting-stent-in-all-comers-population-insight-from-the-ulisse-registry-ultimaster-italian-multicenter-all-comers-stent-registry
#16
Cosmo Godino, Alessandro Beneduce, Giuseppe Ferrante, Alfonso Ielasi, Andrea Carlo Pivato, Mauro Chiarito, Alberto Cappelletti, Giulia Perfetti, Valeria Magni, Eugenio Prati, Stefania Falcone, Adele Pierri, Stefano De Martini, Matteo Montorfano, Rosario Parisi, David Rutigliano, Nicola Locuratolo, Angelo Anzuini, Maurizio Tespilli, Alberto Margonato, Alberto Benassi, Carlo Briguori, Franco Fabbiocchi, Bernhard Reimers, Antonio Bartorelli, Antonio Colombo
BACKGROUND: This study was designed to confirm in a large population of unselected patients the promising results of Ultimaster® biodegradable polymer sirolimus-eluting stent (BP-SES) already shown in previous trial. METHODS: ULISSE is an observational, multicenter, national registry evaluating all patients undergoing PCI with the Ultimaster® BP-SES. Incidence of 1-year TLF (cardiac death or target vessel MI or clinically indicated TLR) was the primary endpoint...
June 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29619983/acute-thrombogenicity-of-fluoropolymer-coated-versus-biodegradable-and-polymer-free-stents
#17
Sho Torii, Qi Cheng, Hiroyoshi Mori, Michael J Lipinski, Eduardo Acampado, Laura E L Perkins, Syed F Hossainy, Stephen D Pacetti, Frank D Kolodgie, Renu Virmani, Aloke V Finn
AIMS: Durable-fluoropolymer coated everolimus-eluting stents (FP-EES) have shown lower rates of stent thrombosis (ST) versus bare-metal stents (BMS) and 1st-generation bioabsorbable-polymer (BP) DES. However, the specific role of the FP in thromboresistance has not been explored. METHODS AND RESULTS: A total of 57 stents were assessed in 3 separate ex-vivo swine arterio-venous shunt-model experiments [1st-shunt-experiment, custom-made fluoropolymer-coated BMS (FP-only) vs...
April 3, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29607135/ultrathin-strut-biodegradable-polymer-sirolimus-eluting-stents-being-wary-or-going-with-the-flow
#18
EDITORIAL
Salvatore Cassese, Anna Lena Lahmann, Michael Joner
No abstract text is available yet for this article.
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29606869/propylthiouracil-coated-biodegradable-polymer-inhibited-neointimal-formation-and-enhanced-re-endothelialization-after-vascular-injury
#19
Shang-Hung Chang, Cheng-Hung Lee, Yung-Hsin Yeh, Shih-Jung Liu, Chao-Jan Wang, Ming-Yi Hsu, Wei-Jan Chen
Background: The drug-eluting stent is a standard approach for the treatment of coronary artery disease. Propylthiouracil (PTU), an antithyroid drug, has been proven to suppress neointimal formation after balloon injury. Materials and methods: This study used a biodegradable polymer coating with PTU to test its effects on platelet function, re-endothelialization, and neointimal formation after vascular injury. Electrospinning was used to fabricate hybrid stents and generate PTU-loaded nanofibers...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29589672/the-synergy-stent-in-high-bleeding-risk-patients-why-design-matters
#20
Mauro Chiarito, Davide Cao, Francesco Cannata, Cristina Panico, Bernhard Reimers, Giulio G Stefanini
Antithrombotic management after percutaneous coronary intervention is based on dual antiplatelet therapy (DAPT), that has unequivocally shown to reduce the risk of recurrent ischemic events at cost of an important risk of bleeding. In order to balance ischemic and bleeding risks, DAPT duration should be based on patients and lesions features as well as stent type. Based on these considerations, patients at high bleeding risk (HBR) undergoing PCI represent a challenging subgroup. The Synergy stent (Boston Scientific, Marlborough, MA, USA) is a new-generation everolimus-eluting stent with a biodegradable polymer coating, presenting several features that have the potential to reduce acute and long-term thrombogenicity and the subsequent need for DAPT...
March 28, 2018: Minerva Cardioangiologica
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