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Myocardial fibrosis mortality

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https://www.readbyqxmd.com/read/28445944/angiotensin-converting-enzyme-2-overexpression-protects-against-doxorubicin-induced-cardiomyopathy-by-multiple-mechanisms-in-rats
#1
Hui Ma, Jing Kong, Yu-Lin Wang, Jun-Long Li, Nai-Hao Hei, Xin-Ran Cao, Jing-Jing Yang, Wen-Jiang Yan, Wen-Jing Liang, Hong-Yan Dai, Bo Dong
Angiotensin-converting enzyme 2 (ACE2) is considered a potential therapeutic target of the renin-angiotensin system (RAS) for the treatment of cardiovascular diseases. We aimed to explore the effects of ACE2 overexpression on doxorubicin-induced cardiomyopathy in rats. Rats were randomly divided into treatment and control groups. The rats of treatment group were injected intraperitoneally with 6 doses of doxorubicin (2.5 mg/kg) within a period of two weeks. Two weeks after the initial injection of doxorubicin, these rats were randomly divided into Mock, Ad-EGFP, Ad-ACE2, and Cilazapril groups...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28426885/prognostic-implications-of-left-ventricular-global-longitudinal-strain-in-heart-failure-patients-with-narrow-qrs-complex-treated-with-cardiac-resynchronization-therapy-a-subanalysis-of-the-randomized-echocrt-trial
#2
Jeroen J Bax, Victoria Delgado, Peter Sogaard, Jagmeet P Singh, William T Abraham, Jeffrey S Borer, Kenneth Dickstein, Daniel Gras, Josep Brugada, Michele Robertson, Ian Ford, Henry Krum, Johannes Holzmeister, Frank Ruschitzka, John Gorcsan
Aim: Left ventricular (LV) global longitudinal strain (GLS) reflects LV systolic function and correlates inversely with the extent of LV myocardial scar and fibrosis. The present subanalysis of the Echocardiography Guided CRT trial investigated the prognostic value of LV GLS in patients with narrow QRS complex. Methods and results: Left ventricular (LV) global longitudinal strain (GLS) was measured on the apical 2-, 4- and 3-chamber views using speckle tracking analysis...
March 7, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28426774/the-role-of-air-pollution-in-myocardial-remodeling
#3
A M de Oliveira-Fonoff, C Mady, F G Pessoa, K C B Fonseca, V M C Salemi, F Fernandes, P H N Saldiva, F J A Ramires
BACKGROUND: Excessive air pollution in urban environments can impact morbidity and mortality. The authors evaluated the role of particulate matter2.5 (PM2.5) in structural, geometric, and functional remodeling in hearts, using an experimental model of myocardial infarction. METHODS AND FINDINGS: Seventy-five rats were divided into 5 groups: control (CG), CG exposed to PM2.5 pollution (CGP), myocardial infarcted group (MI), infarcted group immediately exposed to pollution (IGP-I), and infarcted group previously exposed to pollution and kept exposed after infarction (IGP-II)...
2017: PloS One
https://www.readbyqxmd.com/read/28395009/an-overview-of-the-inflammatory-signalling-mechanisms-in-the-myocardium-underlying-the-development-of-diabetic-cardiomyopathy
#4
Giacomo Frati, Leonardo Schirone, Isotta Chimenti, Derek Yee, Giuseppe Biondi-Zoccai, Massimo Volpe, Sebastiano Sciarretta
Heart failure is a highly morbid and mortal clinical condition that represents the last stage of most cardiovascular disorders. Diabetes is strongly associated with an increased incidence of heart failure and directly promotes cardiac hypertrophy, fibrosis, and apoptosis. These changes, in turn, contribute to the development of ventricular dysfunction. The clinical condition associated with the spectrum of cardiac abnormalities induced by diabetes is termed diabetic cardiomyopathy. Myocardial inflammation has recently emerged as a pathophysiological process contributing to cardiac hypertrophy, fibrosis, and dysfunction in cardiac diseases...
March 15, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28392564/the-immunology-of-atherosclerosis
#5
REVIEW
Anton Gisterå, Göran K Hansson
Cardiovascular disease is the leading cause of death worldwide, both in the general population and among patients with chronic kidney disease (CKD). In most cases, the underlying cause of the cardiovascular event is atherosclerosis - a chronic inflammatory disease. CKD accelerates atherosclerosis via augmentation of inflammation, perturbation of lipid metabolism, and other mechanisms. In the artery wall, subendothelial retention of plasma lipoproteins triggers monocyte-derived macrophages and T helper type 1 (TH1) cells to form atherosclerotic plaques...
April 10, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28382425/characteristics-of-pr-interval-as-predictor-for-atrial-fibrillation-association-with-biomarkers-and-outcomes
#6
REVIEW
Katja Schumacher, Nikolaos Dagres, Gerhard Hindricks, Daniela Husser, Andreas Bollmann, Jelena Kornej
The PR interval may be considered as a simple and easily obtainable predictor for adverse events, including atrial fibrillation (AF), pacemaker implantation, and mortality. Interestingly, both high and low extremes of the PR duration are associated with AF risk. However, the results regarding PR prolongation as a risk factor for AF are inconsistent. Some studies have analyzed the impact of P duration (as a part of the PR interval) and demonstrated that the P-duration contributes to the length of PR interval and adverse outcomes...
April 5, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28380414/the-role-of-sirt1-in-diabetic-cardiomyopathy
#7
REVIEW
Hedyieh Karbasforooshan, Gholamreza Karimi
The prevalence of diabetes mellitus (DM) has been increasing worldwide. Diabetic cardiomyopathy (DCP) is the major risk for diabetes associated morbidity and mortality. Hyperglycemia and hyperinsulinemia play an indispensable role in underlying mechanisms of DCP. They increase advanced glycation end products (AGEs) following a series of events leading to myocardial damage and cardiomyopathy which include oxidative stress, increased inflammation, fibrosis, hypertrophy and apoptosis. SIRT1 is a nicotinamide adenosine dinucleotide (NAD)-dependent deacetylase that removes acetyl groups from proteins which can be implicated in DCP...
April 2, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28371893/tissue-transglutaminase-induction-in-the-pressure-overloaded-myocardium-regulates-matrix-remodeling
#8
Arti V Shinde, Marcin Dobaczewski, Judith J de Haan, Amit Saxena, Kang-Kon Lee, Ying Xia, Wei Chen, Ya Su, Waqas Hanif, Inderpreet Kaur Madahar, Victor M Paulino, Gerry Melino, Nikolaos G Frangogiannis
Aims: : Tissue transglutaminase (tTG) is induced in injured and remodeling tissues, and modulates cellular phenotype, while contributing to matrix cross-linking. Our study tested the hypothesis that tTG may be expressed in the pressure-overloaded myocardium, and may regulate cardiac function, myocardial fibrosis and chamber remodeling. Methods and results: In order to test the hypothesis, wildtype and tTG null mice were subjected to pressure overload induced through transverse aortic constriction...
March 28, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28357065/role-of-micrornas-in-the-pathogenesis-of-diabetic-cardiomyopathy
#9
Xinyu Liu, Shixue Liu
The morbidity of diabetes mellitus has been increasing annually. As a progressive metabolic disorder, chronic complications occur in the late stage of diabetes. In addition, cardiovascular diseases account for the major cause of morbidity and mortality among the diabetic population worldwide. Diabetic cardiomyopathy (DCM) is a type of diabetic heart disease. Patients with DCM show symptoms and signs of heart failure while no specific cause, such as coronary disease, hypertension, alcohol consumption, or other structural heart diseases has been identified...
February 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28349062/imaging-of-myocardial-fibrosis-in-patients-with-end-stage-renal-disease-current-limitations-and-future-possibilities
#10
REVIEW
M P M Graham-Brown, A S Patel, D J Stensel, D S March, A-M Marsh, J McAdam, G P McCann, J O Burton
Cardiovascular disease in patients with end-stage renal disease (ESRD) is driven by a different set of processes than in the general population. These processes lead to pathological changes in cardiac structure and function that include the development of left ventricular hypertrophy and left ventricular dilatation and the development of myocardial fibrosis. Reduction in left ventricular hypertrophy has been the established goal of many interventional trials in patients with chronic kidney disease, but a recent systematic review has questioned whether reduction of left ventricular hypertrophy improves cardiovascular mortality as previously thought...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28325140/vitamins-in-heart-failure-friend-or-enemy
#11
George Georgiopoulos, Christina Chrysohoou, Georgia Vogiatzi, Nikolaos Magkas, Ippokratis Bournelis, Sofia Bampali, Damien Gruson, Dimitris Tousoulis
BACKGROUND: The failing heart is characterized by a depleted metabolic energy reserve and the up-regulation of several molecular mechanisms leading to cardiac hypertrophy, inflammation, fibrosis, angiogenesis, and apoptosis. Dietary or non-dietary supplementation of vitamins could potentially benefit energy balance. OBJECTIVE: The objective of the present study was to evaluate all available information on vitamins supplementation in patients with chronic HF for possible beneficial effect on metabolic, inotropic, chronotropic and hemodynamic indices...
March 20, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28320043/effects-of-ranolazine-in-a-model-of-doxorubicin-induced-left-ventricle-diastolic-dysfunction
#12
Donato Cappetta, Grazia Esposito, Raffaele Coppini, Elena Piegari, Rosa Russo, Loreta Pia Ciuffreda, Alessia Rivellino, Lorenzo Santini, Concetta Rafaniello, Cristina Scavone, Francesco Rossi, Liberato Berrino, Konrad Urbanek, Antonella De Angelis
BACKGROUND AND PURPOSE: Doxorubicin (DOXO) is a highly effective anticancer drug but its clinical application is impeded by cardiotoxicity. Asymptomatic diastolic dysfunction can be the earliest manifestation of DOXO cardiotoxicity. Therefore, a search for therapeutic intervention that can interfere with early manifestations and possibly prevent late cardiotoxicity is warranted. Increased DOXO-dependent reactive oxygen species may explain, in part, Ca(2+) and Na(+) overload that contributes to diastolic dysfunction and development of heart failure...
March 20, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28317477/circulating-biomarkers-of-collagen-metabolism-and-prognosis-of-heart-failure-with-reduced-or-mid-range-ejection-fraction
#13
Joana Moura Ferreira, Sara Moura Ferreira, Maria João Ferreira, Inês Falcão-Pires
BACKGROUND: Change in the architecture and composition of cardiac extracellular matrix is a key element in adverse cardiac remodeling that occurs during heart failure. Most of the times, the result is the development of fibrosis, which has a huge impact on the pathophysiology and clinical outcomes of heart failure syndromes. Several molecules related to collagen metabolism detectable in the blood have been proposed as biomarkers of myocardial fibrosis. Despite concerns regarding the true ability of these biomarkers to reflect quantitative and qualitative changes in myocardial collagen, a growing body of evidence suggests that they may play a potential role in several aspects of heart failure management...
March 17, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28292968/micu1-alleviates-diabetic-cardiomyopathy-through-mitochondrial-ca-2-dependent-antioxidant-response
#14
Lele Ji, Fengzhou Liu, Zhe Jing, Qichao Huang, Ya Zhao, Haiyan Cao, Jun Li, Chun Yin, Jinliang Xing, Fei Li
Diabetic cardiomyopathy is a major cause of mortality in diabetic patients, but specific strategies for prevention or treatment of diabetic cardiomyopathy have not been clarified yet. MICU1 is a key regulator of mitochondria Ca(2+) uptake, which plays important roles in regulating mitochondrial oxidative phosphorylation and redox balance. However, to date, the significance of MICU1 in diabetic hearts has never been investigated. Here, we demonstrated that MICU1 was downregulated in db/db mouse heart, which contributes to myocardial apoptosis in diabetes...
March 14, 2017: Diabetes
https://www.readbyqxmd.com/read/28273426/a-primer-on-current-progress-in-cardiac-fibrosis
#15
Danah Al Hattab, Michael Paul Czubryt
Cardiac fibrosis is a significant global health problem that is closely associated with multiple forms of cardiovascular disease, including myocardial infarction, dilated cardiomyopathy and diabetes. Fibrosis increases myocardial wall stiffness due to excessive extracellular matrix deposition, causing impaired systolic and diastolic function and facilitating arrhythmogenesis. As a result, patient morbidity and mortality are often dramatically elevated compared to those with cardiovascular disease but without overt fibrosis, demonstrating that fibrosis itself is both a pathologic response to existing disease and a significant risk factor for exacerbation of the underlying condition...
March 8, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28272448/aggravated-myocardial-infarction-induced-cardiac-remodeling-and-heart-failure-in-histamine-deficient-mice
#16
Jinmiao Chen, Tao Hong, Suling Ding, Long Deng, Mieradilijiang Abudupataer, Weiwei Zhang, Minghong Tong, Jianguo Jia, Hui Gong, Yunzeng Zou, Timothy C Wang, Junbo Ge, Xiangdong Yang
Histamine has pleiotropic pathophysiological effects, but its role in myocardial infarction (MI)-induced cardiac remodeling remains unclear. Histidine decarboxylase (HDC) is the main enzyme involved in histamine production. Here, we clarified the roles of HDC-expressing cells and histamine in heart failure post-MI using HDC-EGFP transgenic mice and HDC-knockout (HDC(-/-)) mice. HDC(+)CD11b(+) myeloid cell numbers markedly increased in the injured hearts, and histamine levels were up-regulated in the circulation post-MI...
March 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28268171/diastolic-dysfunction-in-hypertension
#17
R Nazário Leão, P Marques da Silva
Hypertension and coronary heart disease, often coexisting, are the most common risk factors for heart failure. The progression of hypertensive heart disease involves myocardial fibrosis and alterations in the left ventricular geometry that precede the functional change, initially asymptomatic. The left ventricular diastolic dysfunction is part of this continuum being defined by the presence of left ventricular diastolic dysfunction without signs or symptoms of heart failure or poor left ventricular systolic function...
March 3, 2017: Hipertensión y Riesgo Vascular
https://www.readbyqxmd.com/read/28247849/meta-analysis-of-the-usefulness-of-plasma-galectin-3-to-predict-the-risk-of-mortality-in-patients-with-heart-failure-and-in-the-general-population
#18
Tasnim F Imran, Hyun Joon Shin, Njambi Mathenge, Frank Wang, Bernard Kim, Jacob Joseph, J Michael Gaziano, Luc Djoussé
Galectin-3 is an emerging biomarker of myocardial fibrosis, inflammation, and immune response. We sought to examine the relation of plasma galectin-3 with cardiovascular (CVD) mortality, all-cause mortality, and incident heart failure (HF). We performed a literature search for all relevant publications using Ovid MEDLINE, Google Scholar, and other databases up to January 2016. Two reviewers independently extracted data and assessed risk of bias. We extracted hazard ratios (HRs) from regression models that adjusted for age, gender, race, body mass index, smoking, hypertension, hyperlipidemia, diabetes, natriuretic peptides, and renal function, when available...
January 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28238236/the-impact-of-gender-on-outcomes-following-transcatheter-aortic-valve-implantation-true-effect-or-bias
#19
Vasileios F Panoulas, Neil Ruparelia, Russel Franks, Sayan Sen, Ben Ariff, Nilesh Sutaria, Angela Frame, Petros Nihoyannopoulos, Iqbal S Malik, Ghada W Mikhail
Transcatheter aortic valve implantation (TAVI) is currently the treatment of choice for patients with severe aortic stenosis (AS) who are unsuitable for surgical aortic valve replacement (SAVR), and is an acceptable alternative for those at high and intermediate surgical risk. In published TAVI registries and meta-analyses, whilst women are significantly older they present with fewer comorbidities compared to men (including coronary artery disease, peripheral vascular disease, diabetes and chronic obstructive pulmonary disease)...
September 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28223437/long-term-administration-of-eicosapentaenoic-acid-improves-post-myocardial-infarction-cardiac-remodeling-in-mice-by-regulating-macrophage-polarization
#20
Masayuki Takamura, Keisuke Kurokawa, Hiroshi Ootsuji, Oto Inoue, Hikari Okada, Ayano Nomura, Shuichi Kaneko, Soichiro Usui
BACKGROUND: Consumption of n-3 fatty acids reduces the incidence of cardiovascular mortality in populations that consume diets rich in fish oil. Eicosapentaenoic acid (EPA) is an n-3 fatty acid known to reduce the frequency of nonfatal coronary events; however, the frequency of mortality after myocardial infarction (MI) is not reduced. The aims of this study were to determine whether long-term administration of EPA regulated cardiac remodeling after MI and to elucidate the underlying therapeutic mechanisms of EPA...
February 21, 2017: Journal of the American Heart Association
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