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Myocardial fibrosis mortality

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https://www.readbyqxmd.com/read/28325140/vitamins-in-heart-failure-friend-or-enemy
#1
George Georgiopoulos, Christina Chrysohoou, Georgia Vogiatzi, Nikolaos Magkas, Ippokratis Bournelis, Sofia Bampali, Damien Gruson, Dimitris Tousoulis
BACKGROUND: The failing heart is characterized by a depleted metabolic energy reserve and the up-regulation of several molecular mechanisms leading to cardiac hypertrophy, inflammation, fibrosis, angiogenesis, and apoptosis. Dietary or non-dietary supplementation of vitamins could potentially benefit energy balance. OBJECTIVE: The objective of the present study was to evaluate all available information on vitamins supplementation in patients with chronic HF for possible beneficial effect on metabolic, inotropic, chronotropic and hemodynamic indices...
March 20, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28320043/effects-of-ranolazine-in-a-model-of-doxorubicin-induced-left-ventricle-diastolic-dysfunction
#2
Donato Cappetta, Grazia Esposito, Raffaele Coppini, Elena Piegari, Rosa Russo, Loreta Pia Ciuffreda, Alessia Rivellino, Lorenzo Santini, Concetta Rafaniello, Cristina Scavone, Francesco Rossi, Liberato Berrino, Konrad Urbanek, Antonella De Angelis
BACKGROUND AND PURPOSE: Doxorubicin (DOXO) is a highly effective anticancer drug but its clinical application is impeded by cardiotoxicity. Asymptomatic diastolic dysfunction can be the earliest manifestation of DOXO cardiotoxicity. Therefore, a search for therapeutic intervention that can interfere with early manifestations and possibly prevent late cardiotoxicity is warranted. Increased DOXO-dependent reactive oxygen species may explain, in part, Ca(2+) and Na(+) overload that contributes to diastolic dysfunction and development of heart failure...
March 20, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28317477/circulating-biomarkers-of-collagen-metabolism-and-prognosis-of-heart-failure-with-reduced-or-mid-range-ejection-fraction
#3
Joana Moura Ferreira, Sara Moura Ferreira, Maria João Ferreira, Inês Falcão-Pires
BACKGROUND: Change in the architecture and composition of cardiac extracellular matrix is a key element in adverse cardiac remodeling that occurs during heart failure. Most of the times, the result is the development of fibrosis, which has a huge impact on the pathophysiology and clinical outcomes of heart failure syndromes. Several molecules related to collagen metabolism detectable in the blood have been proposed as biomarkers of myocardial fibrosis. Despite concerns regarding the true ability of these biomarkers to reflect quantitative and qualitative changes in myocardial collagen, a growing body of evidence suggests that they may play a potential role in several aspects of heart failure management...
March 17, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28292968/micu1-alleviates-diabetic-cardiomyopathy-through-mitochondrial-ca-2-dependent-antioxidant-response
#4
Lele Ji, Fengzhou Liu, Zhe Jing, Qichao Huang, Ya Zhao, Haiyan Cao, Jun Li, Chun Yin, Jinliang Xing, Fei Li
Diabetic cardiomyopathy is a major cause of mortality in diabetic patients, but specific strategies for prevention or treatment of diabetic cardiomyopathy have not been clarified yet. MICU1 is a key regulator of mitochondria Ca(2+) uptake, which plays important roles in regulating mitochondrial oxidative phosphorylation and redox balance. However, to date, the significance of MICU1 in diabetic hearts has never been investigated. Here, we demonstrated that MICU1 was downregulated in db/db mouse heart, which contributes to myocardial apoptosis in diabetes...
March 14, 2017: Diabetes
https://www.readbyqxmd.com/read/28273426/a-primer-on-current-progress-in-cardiac-fibrosis
#5
Danah Al Hattab, Michael Paul Czubryt
Cardiac fibrosis is a significant global health problem that is closely associated with multiple forms of cardiovascular disease, including myocardial infarction, dilated cardiomyopathy and diabetes. Fibrosis increases myocardial wall stiffness due to excessive extracellular matrix deposition, causing impaired systolic and diastolic function and facilitating arrhythmogenesis. As a result, patient morbidity and mortality are often dramatically elevated compared to those with cardiovascular disease but without overt fibrosis, demonstrating that fibrosis itself is both a pathologic response to existing disease and a significant risk factor for exacerbation of the underlying condition...
March 8, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28272448/aggravated-myocardial-infarction-induced-cardiac-remodeling-and-heart-failure-in-histamine-deficient-mice
#6
Jinmiao Chen, Tao Hong, Suling Ding, Long Deng, Mieradilijiang Abudupataer, Weiwei Zhang, Minghong Tong, Jianguo Jia, Hui Gong, Yunzeng Zou, Timothy C Wang, Junbo Ge, Xiangdong Yang
Histamine has pleiotropic pathophysiological effects, but its role in myocardial infarction (MI)-induced cardiac remodeling remains unclear. Histidine decarboxylase (HDC) is the main enzyme involved in histamine production. Here, we clarified the roles of HDC-expressing cells and histamine in heart failure post-MI using HDC-EGFP transgenic mice and HDC-knockout (HDC(-/-)) mice. HDC(+)CD11b(+) myeloid cell numbers markedly increased in the injured hearts, and histamine levels were up-regulated in the circulation post-MI...
March 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28268171/diastolic-dysfunction-in-hypertension
#7
R Nazário Leão, P Marques da Silva
Hypertension and coronary heart disease, often coexisting, are the most common risk factors for heart failure. The progression of hypertensive heart disease involves myocardial fibrosis and alterations in the left ventricular geometry that precede the functional change, initially asymptomatic. The left ventricular diastolic dysfunction is part of this continuum being defined by the presence of left ventricular diastolic dysfunction without signs or symptoms of heart failure or poor left ventricular systolic function...
March 3, 2017: Hipertensión y Riesgo Vascular
https://www.readbyqxmd.com/read/28247849/meta-analysis-of-the-usefulness-of-plasma-galectin-3-to-predict-the-risk-of-mortality-in-patients-with-heart-failure-and-in-the-general-population
#8
Tasnim F Imran, Hyun Joon Shin, Njambi Mathenge, Frank Wang, Bernard Kim, Jacob Joseph, J Michael Gaziano, Luc Djoussé
Galectin-3 is an emerging biomarker of myocardial fibrosis, inflammation, and immune response. We sought to examine the relation of plasma galectin-3 with cardiovascular (CVD) mortality, all-cause mortality, and incident heart failure (HF). We performed a literature search for all relevant publications using Ovid MEDLINE, Google Scholar, and other databases up to January 2016. Two reviewers independently extracted data and assessed risk of bias. We extracted hazard ratios (HRs) from regression models that adjusted for age, gender, race, body mass index, smoking, hypertension, hyperlipidemia, diabetes, natriuretic peptides, and renal function, when available...
January 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28238236/the-impact-of-gender-on-outcomes-following-transcatheter-aortic-valve-implantation-true-effect-or-bias
#9
Vasileios F Panoulas, Neil Ruparelia, Russel Franks, Sayan Sen, Ben Ariff, Nilesh Sutaria, Angela Frame, Petros Nihoyannopoulos, Iqbal S Malik, Ghada W Mikhail
Transcatheter aortic valve implantation (TAVI) is currently the treatment of choice for patients with severe aortic stenosis (AS) who are unsuitable for surgical aortic valve replacement (SAVR), and is an acceptable alternative for those at high and intermediate surgical risk. In published TAVI registries and meta-analyses, whilst women are significantly older they present with fewer comorbidities compared to men (including coronary artery disease, peripheral vascular disease, diabetes and chronic obstructive pulmonary disease)...
September 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28223437/long-term-administration-of-eicosapentaenoic-acid-improves-post-myocardial-infarction-cardiac-remodeling-in-mice-by-regulating-macrophage-polarization
#10
Masayuki Takamura, Keisuke Kurokawa, Hiroshi Ootsuji, Oto Inoue, Hikari Okada, Ayano Nomura, Shuichi Kaneko, Soichiro Usui
BACKGROUND: Consumption of n-3 fatty acids reduces the incidence of cardiovascular mortality in populations that consume diets rich in fish oil. Eicosapentaenoic acid (EPA) is an n-3 fatty acid known to reduce the frequency of nonfatal coronary events; however, the frequency of mortality after myocardial infarction (MI) is not reduced. The aims of this study were to determine whether long-term administration of EPA regulated cardiac remodeling after MI and to elucidate the underlying therapeutic mechanisms of EPA...
February 21, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28217927/hypertension-induced-remodelling-on-the-interactions-of-cardiac-risk-factors
#11
Jakub Tomek, Gil Bub
Hypertension induces considerable cardiac remodelling, such as hypertrophy, interstitial fibrosis, and abnormal activity of cardiac sympathetic nervous system, which are established risk factors in several highly dangerous heart diseases, such as ventricular fibrillation and congestive heart failure. All these risk factors and heart diseases are studied extensively in isolation, but to our knowledge, there is no comprehensive review of their interactions. At the same time, there is growing evidence suggesting that such interactions are numerous and that a successful therapy against a particular condition may have unexpectedly weak effects on mortality, as treated patients may die of a different cause exacerbated by the therapy...
February 19, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28214892/baicalin-attenuates-cardiac-dysfunction-and-myocardial-remodeling-in-a-chronic-pressure-overload-mice-model
#12
Yanqing Zhang, Pingping Liao, Meng'en Zhu, Wei Li, Dan Hu, Siming Guan, Long Chen
BACKGROUND/AIMS: Baicalin has been shown to be effective for various animal models of cardiovascular diseases, such as pulmonary hypertension, atherosclerosis and myocardial ischaemic injury. However, whether baicalin plays a role in cardiac hypertrophy remains unknown. Here we investigated the protective effects of baicalin on cardiac hypertrophy induced by pressure overload and explored the potential mechanisms involved. METHODS: C57BL/6J-mice were treated with baicalin or vehicle following transverse aortic constriction or Sham surgery for up to 8 weeks, and at different time points, cardiac function and heart size measurement and histological and biochemical examination were performed...
February 16, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28183791/appearance-of-qrs-fragmentation-late-after-mustard-senning-repair-is-associated-with-adverse-outcome
#13
Frederik Helsen, Bert Vandenberk, Pieter De Meester, Alexander Van De Bruaene, Charlien Gabriels, Els Troost, Marc Gewillig, Bart Meyns, Rik Willems, Werner Budts
OBJECTIVE: To evaluate if development of fragmented QRS (fQRS) complexes, a marker of inhomogeneous ventricular activation due to myocardial fibrosis, is associated with adverse outcome in adults after Mustard/Senning repair for d-transposition of the great arteries (d-TGA). METHODS: Adults with atrial switch repair for d-TGA were selected from the database of a tertiary care hospital. Exclusion criteria were systemic right ventricular (RV) assist device or heart transplantation (HTx) before the age of 16, or fQRS already present at first visit to the Adult Congenital Heart Disease clinic...
February 9, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28174168/cardiac-overexpression-of-s100a6-attenuates-cardiomyocyte-apoptosis-and-reduces-infarct-size-after-myocardial-ischemia-reperfusion
#14
Azadeh Mofid, Nadav S Newman, Paul J H Lee, Cynthia Abbasi, Pratiek N Matkar, Dmitriy Rudenko, Michael A Kuliszewski, Hao H Chen, Kolsoom Afrasiabi, James N Tsoporis, Anthony O Gramolini, Kim A Connelly, Thomas G Parker, Howard Leong-Poi
BACKGROUND: Cardiomyocyte-specific transgenic mice overexpressing S100A6, a member of the family of EF-hand calcium-binding proteins, develop less cardiac hypertrophy, interstitial fibrosis, and myocyte apoptosis after permanent coronary ligation, findings that support S100A6 as a potential therapeutic target after acute myocardial infarction. Our purpose was to investigate S100A6 gene therapy for acute myocardial ischemia-reperfusion. METHODS AND RESULTS: We first performed in vitro studies to examine the effects of S100A6 overexpression and knockdown in rat neonatal cardiomyocytes...
February 7, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28134413/the-function-and-significance-of-sera2a-in-congestive-heart-failure-an-analysis-of-gene-therapy-trials
#15
REVIEW
Pei Wu, Yuting Zhai, Dongye Li
Congestive heart failure (CHF) is a widespread disease that has a negative impact on health, worldwide. Despite advances in therapies, morbidity, mortality and hospital discharges due to CHF remain high. Advances in the understanding of the pathophysiological mechanisms of CHF and the development of gene transfer technology have made gene therapy a realistic potential therapeutic method for CHF. Among the various potential targets, sarco-endoplasmic reticulum Ca2+-ATPase 2a (SERCA2a), which is an important protein in the regulation of Ca2+ cycling, has piqued the interest of many researchers...
January 30, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28117246/radiotherapy-induced-right-ventricular-remodelling-the-missing-piece-of-the-puzzle
#16
REVIEW
Marijana Tadic, Cesare Cuspidi, Dagmara Hering, Lucia Venneri, Isidora Grozdic-Milojevic
The number of studies demonstrating that right ventricular structure, function and mechanics are valuable predictors of cardiovascular and total morbidity and mortality in patients with a wide range of cardiovascular conditions is constantly increasing. Most studies that evaluated the influence of radiotherapy on the heart focused on left ventricular remodelling, which is why current guidelines only recommend detailed assessment of the left ventricle. Data regarding right ventricular changes in cancer patients treated with radiotherapy are scarce...
February 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/28108129/cardiovascular-impact-in-patients-undergoing-maintenance-hemodialysis-clinical-management-considerations
#17
REVIEW
Srisakul Chirakarnjanakorn, Sankar D Navaneethan, Gary S Francis, W H Wilson Tang
Patients undergoing maintenance hemodialysis develop both structural and functional cardiovascular abnormalities. Despite improvement of dialysis technology, cardiovascular mortality of this population remains high. The pathophysiological mechanisms of these changes are complex and not well understood. It has been postulated that several non-traditional, uremic-related risk factors, especially the long-term uremic state, which may affect the cardiovascular system. There are many cardiovascular changes that occur in chronic kidney disease including left ventricular hypertrophy, myocardial fibrosis, microvascular disease, accelerated atherosclerosis and arteriosclerosis...
April 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28017384/myocardial-fibrosis-and-cardiac-decompensation-in-aortic-stenosis
#18
Calvin W L Chin, Russell J Everett, Jacek Kwiecinski, Alex T Vesey, Emily Yeung, Gavin Esson, William Jenkins, Maria Koo, Saeed Mirsadraee, Audrey C White, Alan G Japp, Sanjay K Prasad, Scott Semple, David E Newby, Marc R Dweck
OBJECTIVES: Cardiac magnetic resonance (CMR) was used to investigate the extracellular compartment and myocardial fibrosis in patients with aortic stenosis, as well as their association with other measures of left ventricular decompensation and mortality. BACKGROUND: Progressive myocardial fibrosis drives the transition from hypertrophy to heart failure in aortic stenosis. Diffuse fibrosis is associated with extracellular volume expansion that is detectable by T1 mapping, whereas late gadolinium enhancement (LGE) detects replacement fibrosis...
December 8, 2016: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27989961/role-of-mineralocorticoid-receptor-activation-in-cardiac-diastolic-dysfunction
#19
REVIEW
Guanghong Jia, Yan Jia, James R Sowers
The prevalence of cardiac diastolic dysfunction and heart failure with preserved ejection, a major cause of morbidity and mortality in the western world, is increasing due, in part, to increases in obesity and type 2 diabetes. Characteristics of cardiac diastolic dysfunction include increased myocardial stiffness and impaired left ventricular (LV) relaxation that is characterized by prolonged isovolumic LV relaxation and slow LV filling. Obesity, insulin resistance and type 2 diabetes, especially in females promote activation of mineralocorticoid receptor (MR) signaling with resultant increases in oxidative stress, maladaptive immune responses, inflammation, and impairment of coronary blood flow and cardiac interstitial fibrosis...
October 28, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27982271/cardiac-magnetic-resonance-verified-myocardial-fibrosis-in-chagas-disease-clinical-correlates-and-risk-stratification
#20
Marly Uellendahl, Maria Eduarda Menezes de Siqueira, Eveline Barros Calado, Roberto Kalil-Filho, Dário Sobral, Clébia Ribeiro, Wilson Oliveira, Silvia Martins, Jagat Narula, Carlos Eduardo Rochitte
Background: Chagas disease (CD) is an important cause of heart failure and mortality, mainly in Latin America. This study evaluated the morphological and functional characteristics of the heart as well the extent of myocardial fibrosis (MF) in patients with CD by cardiac magnetic resonance (CMR). The prognostic value of MF evaluated by myocardial-delayed enhancement (MDE) was compared with that via Rassi score. Methods: This study assessed 39 patients divided into 2 groups: 28 asymptomatic patients as indeterminate form group (IND); and symptomatic patients as Chagas Heart Disease (CHD) group...
November 2016: Arquivos Brasileiros de Cardiologia
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