keyword
https://read.qxmd.com/read/37862664/final-results-of-gerda-on-the-two-neutrino-double-%C3%AE-decay-half-life-of-76-ge
#21
JOURNAL ARTICLE
M Agostini, A Alexander, G R Araujo, A M Bakalyarov, M Balata, I Barabanov, L Baudis, C Bauer, S Belogurov, A Bettini, L Bezrukov, V Biancacci, E Bossio, V Bothe, R Brugnera, A Caldwell, S Calgaro, C Cattadori, A Chernogorov, P-J Chiu, T Comellato, V D'Andrea, E V Demidova, A Di Giacinto, N Di Marco, E Doroshkevich, F Fischer, M Fomina, A Gangapshev, A Garfagnini, C Gooch, P Grabmayr, V Gurentsov, K Gusev, S Hackenmüller, S Hemmer, W Hofmann, J Huang, M Hult, L V Inzhechik, J Janicskó Csáthy, J Jochum, M Junker, V Kazalov, Y Kermaïdic, H Khushbakht, T Kihm, K Kilgus, I V Kirpichnikov, A Klimenko, K T Knöpfle, O Kochetov, V N Kornoukhov, P Krause, V V Kuzminov, M Laubenstein, B Lehnert, M Lindner, I Lippi, A Lubashevskiy, B Lubsandorzhiev, G Lutter, C Macolino, B Majorovits, W Maneschg, L Manzanillas, G Marshall, M Miloradovic, R Mingazheva, M Misiaszek, M Morella, Y Müller, I Nemchenok, M Neuberger, L Pandola, K Pelczar, L Pertoldi, P Piseri, A Pullia, C Ransom, L Rauscher, M Redchuk, S Riboldi, N Rumyantseva, C Sada, S Sailer, F Salamida, S Schönert, J Schreiner, M Schütt, A-K Schütz, O Schulz, M Schwarz, B Schwingenheuer, O Selivanenko, E Shevchik, M Shirchenko, L Shtembari, H Simgen, A Smolnikov, D Stukov, S Sullivan, A A Vasenko, A Veresnikova, C Vignoli, K von Sturm, T Wester, C Wiesinger, M Wojcik, E Yanovich, B Zatschler, I Zhitnikov, S V Zhukov, D Zinatulina, A Zschocke, A J Zsigmond, K Zuber, G Zuzel
We present the measurement of the two-neutrino double-β decay rate of ^{76}Ge performed with the GERDA Phase II experiment. With a subset of the entire GERDA exposure, 11.8 kg yr, the half-life of the process has been determined: T_{1/2}^{2ν}=(2.022±0.018_{stat}±0.038_{syst})×10^{21}  yr. This is the most precise determination of the ^{76}Ge two-neutrino double-β decay half-life and one of the most precise measurements of a double-β decay process...
October 6, 2023: Physical Review Letters
https://read.qxmd.com/read/37749256/il-12-sensing-in-neurons-induces-neuroprotective-cns-tissue-adaptation-and-attenuates-neuroinflammation-in-mice
#22
JOURNAL ARTICLE
Myrto Andreadou, Florian Ingelfinger, Donatella De Feo, Teresa L M Cramer, Selma Tuzlak, Ekaterina Friebel, Bettina Schreiner, Pascale Eede, Shirin Schneeberger, Maria Geesdorf, Frederike Ridder, Christina A Welsh, Laura Power, Daniel Kirschenbaum, Shiva K Tyagarajan, Melanie Greter, Frank L Heppner, Sarah Mundt, Burkhard Becher
Interleukin-12 (IL-12) is a potent driver of type 1 immunity. Paradoxically, in autoimmune conditions, including of the CNS, IL-12 reduces inflammation. The underlying mechanism behind these opposing properties and the involved cellular players remain elusive. Here we map IL-12 receptor (IL-12R) expression to NK and T cells as well as neurons and oligodendrocytes. Conditionally ablating the IL-12R across these cell types in adult mice and assessing their susceptibility to experimental autoimmune encephalomyelitis revealed that the neuroprotective role of IL-12 is mediated by neuroectoderm-derived cells, specifically neurons, and not immune cells...
September 25, 2023: Nature Neuroscience
https://read.qxmd.com/read/37748508/high-dose-rate-brachytherapy-combined-with-pd-1-blockade-as-a-treatment-for-metastatic-adrenocortical-carcinoma-a-single-center-case-series
#23
JOURNAL ARTICLE
Paul Schwarzlmueller, Stefanie Corradini, Max Seidensticker, Petra Zimmermann, Jochen Schreiner, Tanja Maier, Alexandra Triebig, Thomas Knösel, Montserrat Pazos, Thomas Pfluger, Isabel Weigand, Claus Belka, Jens Ricke, Martin Reincke, Ralf Schmidmaier, Matthias Kroiss
The response rate of advanced adrenocortical carcinoma (ACC) to standard chemotherapy with mitotane and etoposide/doxorubicin/cisplatin (EDP-M) is unsatisfactory, and benefit is frequently short lived. Immune checkpoint inhibitors (CPI) have been examined in patient's refractory to EDP-M, but objective response rates are only approximately 15%. High-dose rate brachytherapy (HDR-BT) is a catheter-based internal radiotherapy and expected to favorably combine with immunotherapies. Here we describe three cases of patients with advanced ACC who were treated with HDR-BT and the CPI pembrolizumab...
September 25, 2023: Hormone and Metabolic Research
https://read.qxmd.com/read/37695314/recurrences-of-ventricular-tachycardia-after-stereotactic-arrhythmia-radioablation-arise-outside-the-treated-volume-analysis-of-the-swiss-cohort
#24
JOURNAL ARTICLE
C Herrera Siklody, L Schiappacasse, R Jumeau, T Reichlin, A M Saguner, N Andratschke, O Elicin, F Schreiner, B Kovacs, M Mayinger, A Huber, J J C Verhoeff, P Pascale, J Solana Muñoz, A Luca, G Domenichini, R Moeckli, J Bourhis, E M Ozsahin, E Pruvot
BACKGROUND AND AIMS: Stereotactic arrhythmia radioablation (STAR) has been recently introduced for the management of therapy-refractory ventricular tachycardia (VT). VT recurrences have been reported after STAR but the mechanisms remain largely unknown. We analyzed recurrences in our patients after STAR. METHODS: From 09.2017 to 01.2020, 20 patients (68±8y, LVEF 37±15%) suffering from refractory VT were enrolled, 16/20 with a history of at least 1 electrical storm...
September 11, 2023: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://read.qxmd.com/read/37674593/search-for-tri-nucleon-decays-of-76-ge-in-gerda
#25
JOURNAL ARTICLE
M Agostini, A Alexander, G Araujo, A M Bakalyarov, M Balata, I Barabanov, L Baudis, C Bauer, S Belogurov, A Bettini, L Bezrukov, V Biancacci, E Bossio, V Bothe, R Brugnera, A Caldwell, S Calgaro, C Cattadori, A Chernogorov, P-J Chiu, T Comellato, V D'Andrea, E V Demidova, A Di Giacinto, N Di Marco, E Doroshkevich, F Fischer, M Fomina, A Gangapshev, A Garfagnini, C Gooch, P Grabmayr, V Gurentsov, K Gusev, J Hakenmüller, S Hemmer, W Hofmann, M Hult, L V Inzhechik, J Janicskó Csáthy, J Jochum, M Junker, V Kazalov, Y Kermaïdic, H Khushbakht, T Kihm, K Kilgus, I V Kirpichnikov, A Klimenko, K T Knöpfle, O Kochetov, V N Kornoukhov, P Krause, V V Kuzminov, M Laubenstein, M Lindner, I Lippi, A Lubashevskiy, B Lubsandorzhiev, G Lutter, C Macolino, B Majorovits, W Maneschg, L Manzanillas, G Marshall, M Misiaszek, M Morella, Y Müller, I Nemchenok, M Neuberger, L Pandola, K Pelczar, L Pertoldi, P Piseri, A Pullia, L Rauscher, M Redchuk, S Riboldi, N Rumyantseva, C Sada, S Sailer, F Salamida, S Schönert, J Schreiner, M Schütt, A-K Schütz, O Schulz, M Schwarz, B Schwingenheuer, O Selivanenko, E Shevchik, M Shirchenko, L Shtembari, H Simgen, A Smolnikov, D Stukov, S Sullivan, A A Vasenko, A Veresnikova, C Vignoli, K von Sturm, T Wester, C Wiesinger, M Wojcik, E Yanovich, B Zatschler, I Zhitnikov, S V Zhukov, D Zinatulina, A Zschocke, A J Zsigmond, K Zuber, G Zuzel
We search for tri-nucleon decays of <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:msup><mml:mrow/><mml:mn>76</mml:mn></mml:msup></mml:math>Ge in the dataset from the GERmanium Detector Array (GERDA) experiment. Decays that populate excited levels of the daughter nucleus above the threshold for particle emission lead to disintegration and are not considered. The ppp-, ppn-, and pnn-decays lead to <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:msup><mml:mrow/><mml:mn>73</mml:mn></mml:msup></mml:math>Cu, <mml:math xmlns:mml="https://www...
2023: European Physical Journal. C, Particles and Fields
https://read.qxmd.com/read/37674007/author-correction-modeling-idiopathic-autism-in-forebrain-organoids-reveals-an-imbalance-of-excitatory-cortical-neuron-subtypes-during-early-neurogenesis
#26
Alexandre Jourdon, Feinan Wu, Jessica Mariani, Davide Capauto, Scott Norton, Livia Tomasini, Anahita Amiri, Milovan Suvakov, Jeremy D Schreiner, Yeongjun Jang, Arijit Panda, Cindy Khanh Nguyen, Elise M Cummings, Gloria Han, Kelly Powell, Anna Szekely, James C McPartland, Kevin Pelphrey, Katarzyna Chawarska, Pamela Ventola, Alexej Abyzov, Flora M Vaccarino
No abstract text is available yet for this article.
September 6, 2023: Nature Neuroscience
https://read.qxmd.com/read/37616147/statin-prescribing-patterns-in-patient-centered-medical-home-patients-with-nafld
#27
JOURNAL ARTICLE
Allison L Cipriani, Chelsey A Petz, Ellen M Nielsen, Justin Marsden, Andrew D Schreiner
OBJECTIVES: Cardiovascular disease is the leading cause of mortality in patients with nonalcoholic fatty liver disease (NAFLD), and statins play a pivotal role in the primary prevention of cardiovascular events. This study investigates statin prescribing in primary care patients with NAFLD to identify opportunities to address cardiovascular disease risk in this cohort. STUDY DESIGN: Retrospective cohort study of primary care electronic health record data from 2012-2018...
August 2023: American Journal of Managed Care
https://read.qxmd.com/read/37571055/special-packaging-materials-from-recycled-pet-and-metallic-nano-powders
#28
JOURNAL ARTICLE
Romeo C Ciobanu, Mihaela Aradoaei, Alina R Caramitu, Ioana Ion, Cristina M Schreiner, Violeta Tsakiris, Virgil Marinescu, Elena Gabriela Hitruc, Magdalena Aflori
The European methodology for plastics, as a feature of the EU's circular economy activity plan, ought to support the decrease in plastic waste. The improvement of recycled plastics' economics and quality is one important part of this action plan. Additionally, achieving the requirement that all plastic packaging sold in the EU by 2030 be recyclable or reusable is an important objective. This means that food packaging materials should be recycled in a closed loop at the end. One of the most significant engineering polymers is polyethylene terephthalate (PET), which is widely used...
July 25, 2023: Polymers
https://read.qxmd.com/read/37566859/first-dark-matter-search-with-nuclear-recoils-from-the-xenonnt-experiment
#29
JOURNAL ARTICLE
E Aprile, K Abe, F Agostini, S Ahmed Maouloud, L Althueser, B Andrieu, E Angelino, J R Angevaare, V C Antochi, D Antón Martin, F Arneodo, L Baudis, A L Baxter, M Bazyk, L Bellagamba, R Biondi, A Bismark, E J Brookes, A Brown, S Bruenner, G Bruno, R Budnik, T K Bui, C Cai, J M R Cardoso, D Cichon, A P Cimental Chavez, A P Colijn, J Conrad, J J Cuenca-García, J P Cussonneau, V D'Andrea, M P Decowski, P Di Gangi, S Di Pede, S Diglio, K Eitel, A Elykov, S Farrell, A D Ferella, C Ferrari, H Fischer, M Flierman, W Fulgione, C Fuselli, P Gaemers, R Gaior, A Gallo Rosso, M Galloway, F Gao, R Glade-Beucke, L Grandi, J Grigat, H Guan, M Guida, R Hammann, A Higuera, C Hils, L Hoetzsch, N F Hood, J Howlett, M Iacovacci, Y Itow, J Jakob, F Joerg, A Joy, N Kato, M Kara, P Kavrigin, S Kazama, M Kobayashi, G Koltman, A Kopec, F Kuger, H Landsman, R F Lang, L Levinson, I Li, S Li, S Liang, S Lindemann, M Lindner, K Liu, J Loizeau, F Lombardi, J Long, J A M Lopes, Y Ma, C Macolino, J Mahlstedt, A Mancuso, L Manenti, F Marignetti, T Marrodán Undagoitia, K Martens, J Masbou, D Masson, E Masson, S Mastroianni, M Messina, K Miuchi, K Mizukoshi, A Molinario, S Moriyama, K Morå, Y Mosbacher, M Murra, J Müller, K Ni, U Oberlack, B Paetsch, J Palacio, R Peres, C Peters, J Pienaar, M Pierre, V Pizzella, G Plante, J Qi, J Qin, D Ramírez García, R Singh, L Sanchez, J M F Dos Santos, I Sarnoff, G Sartorelli, J Schreiner, D Schulte, P Schulte, H Schulze Eißing, M Schumann, L Scotto Lavina, M Selvi, F Semeria, P Shagin, S Shi, E Shockley, M Silva, H Simgen, A Takeda, P-L Tan, A Terliuk, D Thers, F Toschi, G Trinchero, C Tunnell, F Tönnies, K Valerius, G Volta, C Weinheimer, M Weiss, D Wenz, C Wittweg, T Wolf, V H S Wu, Y Xing, D Xu, Z Xu, M Yamashita, L Yang, J Ye, L Yuan, G Zavattini, M Zhong, T Zhu
We report on the first search for nuclear recoils from dark matter in the form of weakly interacting massive particles (WIMPs) with the XENONnT experiment, which is based on a two-phase time projection chamber with a sensitive liquid xenon mass of 5.9 ton. During the (1.09±0.03)  ton yr exposure used for this search, the intrinsic ^{85}Kr and ^{222}Rn concentrations in the liquid target are reduced to unprecedentedly low levels, giving an electronic recoil background rate of (15...
July 28, 2023: Physical Review Letters
https://read.qxmd.com/read/37564129/because-i-m-happy-positive-affect-and-its-predictive-value-for-future-disease-activity-in-patients-with-inflammatory-bowel-diseases-a-retrospective-cohort-study
#30
JOURNAL ARTICLE
Brian M Lang, Martina Ledergerber, Sebastian Bruno Ulrich Jordi, Niklas Krupka, Luc Biedermann, Philipp Schreiner, Pascal Juillerat, Jacqueline Wyss, Stephan R Vavricka, Jonas Zeitz, Roland von Känel, Gerhard Rogler, Niko Beerenwinkel, Benjamin Misselwitz
BACKGROUND: While the detrimental impact of negative emotions on the clinical course of inflammatory bowel disease (IBD) and quality of life has been extensively investigated, evidence for a potential impact of positive emotions is scarce. OBJECTIVES: We aim to analyse contributing factors of positive affect and their predictive value for disease course in IBD patients. DESIGN: In this retrospective cohort study, epidemiological, psychosocial and IBD disease characteristics of Swiss IBD cohort study patients were analysed longitudinally...
2023: Therapeutic Advances in Gastroenterology
https://read.qxmd.com/read/37563294/modeling-idiopathic-autism-in-forebrain-organoids-reveals-an-imbalance-of-excitatory-cortical-neuron-subtypes-during-early-neurogenesis
#31
JOURNAL ARTICLE
Alexandre Jourdon, Feinan Wu, Jessica Mariani, Davide Capauto, Scott Norton, Livia Tomasini, Anahita Amiri, Milovan Suvakov, Jeremy D Schreiner, Yeongjun Jang, Arijit Panda, Cindy Khanh Nguyen, Elise M Cummings, Gloria Han, Kelly Powell, Anna Szekely, James C McPartland, Kevin Pelphrey, Katarzyna Chawarska, Pamela Ventola, Alexej Abyzov, Flora M Vaccarino
Idiopathic autism spectrum disorder (ASD) is highly heterogeneous, and it remains unclear how convergent biological processes in affected individuals may give rise to symptoms. Here, using cortical organoids and single-cell transcriptomics, we modeled alterations in the forebrain development between boys with idiopathic ASD and their unaffected fathers in 13 families. Transcriptomic changes suggest that ASD pathogenesis in macrocephalic and normocephalic probands involves an opposite disruption of the balance between excitatory neurons of the dorsal cortical plate and other lineages such as early-generated neurons from the putative preplate...
September 2023: Nature Neuroscience
https://read.qxmd.com/read/37450817/searching-for-heavy-dark-matter-near-the-planck-mass-with-xenon1t
#32
JOURNAL ARTICLE
E Aprile, K Abe, S Ahmed Maouloud, L Althueser, B Andrieu, E Angelino, J R Angevaare, V C Antochi, D Antón Martin, F Arneodo, L Baudis, A L Baxter, M Bazyk, L Bellagamba, R Biondi, A Bismark, E J Brookes, A Brown, S Bruenner, G Bruno, R Budnik, T K Bui, C Cai, J M R Cardoso, D Cichon, A P Cimental Chavez, M Clark, A P Colijn, J Conrad, J J Cuenca-García, J P Cussonneau, V D'Andrea, M P Decowski, P Di Gangi, S Di Pede, S Diglio, K Eitel, A Elykov, S Farrell, A D Ferella, C Ferrari, H Fischer, M Flierman, W Fulgione, C Fuselli, P Gaemers, R Gaior, A Gallo Rosso, M Galloway, F Gao, R Glade-Beucke, L Grandi, J Grigat, H Guan, M Guida, R Hammann, A Higuera, C Hils, L Hoetzsch, N F Hood, J Howlett, M Iacovacci, Y Itow, J Jakob, F Joerg, A Joy, N Kato, M Kara, P Kavrigin, S Kazama, M Kobayashi, G Koltman, A Kopec, F Kuger, H Landsman, R F Lang, L Levinson, I Li, S Li, S Liang, S Lindemann, M Lindner, K Liu, J Loizeau, F Lombardi, J Long, J A M Lopes, Y Ma, C Macolino, J Mahlstedt, A Mancuso, L Manenti, F Marignetti, T Marrodán Undagoitia, K Martens, J Masbou, D Masson, E Masson, S Mastroianni, M Messina, K Miuchi, K Mizukoshi, A Molinario, S Moriyama, K Morå, Y Mosbacher, M Murra, J Müller, K Ni, U Oberlack, B Paetsch, J Palacio, Q Pellegrini, R Peres, C Peters, J Pienaar, M Pierre, V Pizzella, G Plante, T R Pollmann, J Qi, J Qin, D Ramírez García, R Singh, L Sanchez, J M F Dos Santos, I Sarnoff, G Sartorelli, J Schreiner, D Schulte, P Schulte, H Schulze Eißing, M Schumann, L Scotto Lavina, M Selvi, F Semeria, P Shagin, S Shi, E Shockley, M Silva, H Simgen, A Takeda, P-L Tan, A Terliuk, D Thers, F Toschi, G Trinchero, C Tunnell, F Tönnies, K Valerius, G Volta, C Weinheimer, M Weiss, D Wenz, C Wittweg, T Wolf, V H S Wu, Y Xing, D Xu, Z Xu, M Yamashita, L Yang, J Ye, L Yuan, G Zavattini, M Zhong, T Zhu
Multiple viable theoretical models predict heavy dark matter particles with a mass close to the Planck mass, a range relatively unexplored by current experimental measurements. We use 219.4 days of data collected with the XENON1T experiment to conduct a blind search for signals from multiply interacting massive particles (MIMPs). Their unique track signature allows a targeted analysis with only 0.05 expected background events from muons. Following unblinding, we observe no signal candidate events. This Letter places strong constraints on spin-independent interactions of dark matter particles with a mass between 1×10^{12} and 2×10^{17}  GeV/c^{2}...
June 30, 2023: Physical Review Letters
https://read.qxmd.com/read/37418791/obesity-and-its-chronic-inflammation-as-pain-potentiation-factor-in-rats-with-osteoarthritis
#33
JOURNAL ARTICLE
Rafael Tamborena Malheiros, Gabriela Escalante Brites, Elizandra Gomes Schmitt, Laura Smolski Dos Santos, Genifer Erminda Schreiner, Silvia Muller de Moura Sarmento, Itamar Luís Gonçalves, Morgana Duarte da Silva, Vanusa Manfredini
BACKGROUND: Obesity produces the accumulation of adipose tissue and a chronic inflammatory process, while osteoarthritis (OA) is also an inflammatory disorder. OBJECTIVES: to evaluate whether obesity associated to OA may be a factor that increases inflammation and pain. METHODS: Male animals (M) were divided into groups: control (CM), OA-induced pain (MP), obese (OM) and obese with OA-induced pain (OMP). Similarly, females (F) were divided into groups: control (CF), OA-induced pain (FP), obese (OF) and obese with OA-induced pain (OFP)...
July 5, 2023: Cytokine
https://read.qxmd.com/read/37402609/the-influence-of-biological-dmards-on-aseptic-arthroplasty-loosening-a-retrospective-cohort-study
#34
JOURNAL ARTICLE
Markus M Schreiner, Jennifer Straub, Sebastian Apprich, Kevin Staats, Reinhard Windhager, Daniel Aletaha, Christoph Böhler
OBJECTIVE: To investigate whether biological DMARDs affect the risk of aseptic loosening after total hip/knee arthroplasty (THA/TKA) in patients with rheumatoid arthritis (RA). METHODS: We retrospectively identified all patients suffering from RA who underwent THA/TKA at our academic center between 2002 and 2015 and linked them with an existing prospective observational RA database at our institution.The risk of aseptic loosening was estimated using radiological signs of component loosening (RCL)...
July 4, 2023: Rheumatology
https://read.qxmd.com/read/37344387/delivery-of-a-prevention-program-in-large-college-classes-effectiveness-of-the-expectancy-challenge-alcohol-literacy-curriculum
#35
JOURNAL ARTICLE
Jessica N Flori, Amy M Schreiner, Michael E Dunn, Mark J Crisafulli, Gabrielle T Lynch, Robert D Dvorak, Cameron A Davis
Background : Despite modest reductions in alcohol use among college students, drinking-related harms continue to be prevalent. Group-delivered programs have had little impact on drinking except for experiential expectancy challenge interventions that are impractical because they rely on alcohol administration. Expectancy Challenge Alcohol Literacy Curriculum (ECALC), however, offers a non-experiential alternative suitable for widespread implementation for universal, selective, or indicated prevention. Objectives : ECALC has been effective with mandated students, fraternity members, and small classes of 30 or fewer first-year college students...
June 21, 2023: Substance Use & Misuse
https://read.qxmd.com/read/37342908/chronic-alcohol-exposure-alters-action-control-via-hyperactive-premotor-corticostriatal-activity
#36
JOURNAL ARTICLE
Drew C Schreiner, Andrew Wright, Emily T Baltz, Tianyu Wang, Christian Cazares, Christina M Gremel
Alcohol use disorder (AUD) alters decision-making control over actions, but disruptions to the responsible neural circuit mechanisms are unclear. Premotor corticostriatal circuits are implicated in balancing goal-directed and habitual control over actions and show disruption in disorders with compulsive, inflexible behaviors, including AUD. However, whether there is a causal link between disrupted premotor activity and altered action control is unknown. Here, we find that mice chronically exposed to alcohol (chronic intermittent ethanol [CIE]) showed impaired ability to use recent action information to guide subsequent actions...
June 20, 2023: Cell Reports
https://read.qxmd.com/read/37299248/flexible-electromagnetic-shielding-nano-composites-based-on-silicon-and-nife-2-o-4-powders
#37
JOURNAL ARTICLE
Alina R Caramitu, Romeo C Ciobanu, Ioana Ion, Cristina M Schreiner, Mihaela Aradoaei, Violeta Tsakiris, Jana Pintea, Virgil Marinescu
In this paper, the obtaining and characterization of five experimental models of novel polymer composite materials with ferrite nano-powder are presented. The composites were obtained by mechanically mixing two components and pressing the obtained mixture on a hot plate press. The ferrite powders were obtained by an innovative economic co-precipitation route. The characterization of these composites consisted of physical and thermal properties: hydrostatic density, scanning electron microscopy (SEM), and TG DSC thermal analyses, along with functional electromagnetic tests in order to demonstrate the functionality of these materials as electromagnetic shields (magnetic permeability, dielectric characteristics, and shielding effectiveness)...
May 25, 2023: Polymers
https://read.qxmd.com/read/37260092/outcome-of-immunotherapy-in-adrenocortical-carcinoma-a-retrospective-cohort-study
#38
JOURNAL ARTICLE
Hanna Remde, Laura Schmidt-Pennington, Miriam Reuter, Laura-Sophie Landwehr, Marie Jensen, Harald Lahner, Otilia Kimpel, Barbara Altieri, Katharina Laubner, Jochen Schreiner, Joerg Bojunga, Stefan Kircher, Catarina Alisa Kunze, Anne Pohrt, Maria-Veronica Teleanu, Daniel Hübschmann, Albrecht Stenzinger, Hanno Glimm, Stefan Fröhling, Martin Fassnacht, Knut Mai, Matthias Kroiss
OBJECTIVE: Clinical trials with immune checkpoint inhibitors (ICI) in adrenocortical carcinoma (ACC) have yielded contradictory results. We aimed to evaluate treatment response and safety of ICI in ACC in a real-life setting. DESIGN: Retrospective cohort study of 54 patients with advanced ACC receiving ICI as compassionate use at 6 German reference centres between 2016 and 2022. METHODS: Objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS), overall survival (OS), and treatment-related adverse events (TRAE) were assessed...
June 7, 2023: European Journal of Endocrinology
https://read.qxmd.com/read/37258616/genome-wide-dna-methylation-association-study-of-recent-and-cumulative-marijuana-use-in-middle-aged-adults
#39
JOURNAL ARTICLE
Drew R Nannini, Yinan Zheng, Brian T Joyce, Kyeezu Kim, Tao Gao, Jun Wang, David R Jacobs, Pamela J Schreiner, Kristine Yaffe, Philip Greenland, Donald M Lloyd-Jones, Lifang Hou
Marijuana is a widely used psychoactive substance in the US and medical and recreational legalization has risen over the past decade. Despite the growing number of individuals using marijuana, studies investigating the association between epigenetic factors and recent and cumulative marijuana use remain limited. We therefore investigated the association between recent and cumulative marijuana use and DNA methylation levels. Participants from the Coronary Artery Risk Development in Young Adults Study with whole blood collected at examination years (Y) 15 and Y20 were randomly selected to undergo DNA methylation profiling at both timepoints using the Illumina MethylationEPIC BeadChip...
June 2023: Molecular Psychiatry
https://read.qxmd.com/read/37241098/validation-of-the-clif-c-of-score-and-clif-c-aclf-score-to-predict-transplant-free-survival-in-patients-with-liver-cirrhosis-and-concomitant-need-for-intensive-care-unit-treatment
#40
JOURNAL ARTICLE
Michael Nagel, Ruben Westphal, Max Hilscher, Peter R Galle, Jörn M Schattenberg, Oliver Schreiner, Christian Labenz, Marcus Alexander Wörns
Both the Chronic Liver Failure Consortium (CLIF-C) organ failure score (OFs) and the CLIF-C acute-on-chronic-liver failure (ACLF) score (ACLFs) were developed for risk stratification and to predict mortality in patients with liver cirrhosis and ACLF. However, studies validating the predictive ability of both scores in patients with liver cirrhosis and concomitant need for intensive care unit (ICU) treatment are scarce. The aim of the present study is to validate the predictive ability of the CLIF-C OFs and CLIF-C ACLFs regarding the rationale of ongoing ICU treatment and to investigate their predictive ability regarding 28-days (short-), 90-days (medium-), and 365-days (long-term) mortality in patients with liver cirrhosis treated in an ICU...
April 29, 2023: Medicina
keyword
keyword
58893
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.