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https://www.readbyqxmd.com/read/29672801/antisuicidal-effects-in-mood-disorders-are-they-unique-to-lithium
#1
Leonardo Tondo, Ross J Baldessarini
INTRODUCTION: Suicidal behavior is strongly associated with depression in major depressive (MDD) and bipolar (BD) disorders, especially with associated behavioral activation, dysphoria, or agitation. A rare intervention with evidence of suicide risk-reducing as well as mood-stabilizing effects in mood disorder patients is lithium. METHODS: We reviewed available research evidence on associations of long-term treatment with lithium with risk of suicidal behavior. We meta-analyzed 12 randomized trials in 10 reports (with at least 1 suicide in either treatment arm) including both BD and MDD subjects, with particular attention to comparisons of lithium with placebo or other pharmacological treatments...
April 19, 2018: Pharmacopsychiatry
https://www.readbyqxmd.com/read/29665163/lowered-quality-of-life-in-mood-disorders-is-associated-with-increased-neuro-oxidative-stress-and-basal-thyroid-stimulating-hormone-levels-and-use-of-anticonvulsant-mood-stabilizers
#2
Caroline Sampaio Nunes, Michael Maes, Chutima Roomruangwong, Juliana Brum Moraes, Kamila Landucci Bonifacio, Heber Odebrecht Vargas, Decio Sabbatini Barbosa, George Anderson, Luiz Gustavo Piccoli de Melo, Stoyanov Drozdstoj, Estefania Moreira, André F Carvalho, Sandra Odebrecht Vargas Nunes
RATIONALE, AIMS: Major affective disorders including bipolar disorder (BD) and major depressive disorder (MDD) are associated with impaired health-related quality of life (HRQoL). Oxidative stress and subtle thyroid abnormalities may play a pathophysiological role in both disorders. Thus, the current study was performed to examine whether neuro-oxidative biomarkers and thyroid-stimulating hormone (TSH) levels could predict HRQoL in BD and MDD. METHODS: This cross-sectional study enrolled 68 BD and 37 MDD patients and 66 healthy controls...
April 17, 2018: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29652778/does-the-use-of-electrotherapies-increase-the-effectiveness-of-neck-stabilization-exercises-for-improving-pain-disability-mood-and-quality-of-life-in-chronic-neck-pain-a-randomized-controlled-single-blind-study
#3
Hilal Yesil, Simin Hepguler, Umit Dundar, Sahel Taravati, Banu Isleten
STUDY DESIGN: This study was a prospective, randomized, controlled study. OBJECTIVE: The aim of this study was to determine if transcutaneous electrical nerve stimulation (TENS) or interferential current (IFC) increase the effectiveness of neck stabilization exercises on pain, disability, mood, and quality of life for chronic neck pain (CNP). SUMMARY OF BACKGROUND DATA: Neck pain is one of the three most frequently reported complaints of the musculoskeletal system...
April 12, 2018: Spine
https://www.readbyqxmd.com/read/29628501/excitatory-and-inhibitory-synaptic-dysfunction-in-mania-an-emerging-hypothesis-from-animal-model-studies
#4
REVIEW
Yeunkum Lee, Yinhua Zhang, Shinhyun Kim, Kihoon Han
Bipolar disorder (BD) is a common psychiatric disorder characterized by recurrent mood swings between depression and mania, and is associated with high treatment costs. The existence of manic episodes is the defining feature of BD, during which period, patients experience extreme elevation in activity, energy, and mood, with changes in sleep patterns that together severely impair their ability to function in daily life. Despite some limitations in recapitulating the complex features of human disease, several rodent models of mania have been generated and characterized, which have provided important insights toward understanding its underlying pathogenic mechanisms...
April 9, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29621901/the-clinical-effectiveness-and-cost-effectiveness-of-lamotrigine-in-borderline-personality-disorder-a-randomized-placebo-controlled-trial
#5
Mike J Crawford, Rahil Sanatinia, Barbara Barrett, Gillian Cunningham, Oliver Dale, Poushali Ganguli, Geoff Lawrence-Smith, Verity Leeson, Fenella Lemonsky, Georgia Lykomitrou, Alan A Montgomery, Richard Morriss, Jasna Munjiza, Carol Paton, Iwona Skorodzien, Vineet Singh, Wei Tan, Peter Tyrer, Joseph G Reilly
OBJECTIVE: The authors examined whether lamotrigine is a clinically effective and cost-effective treatment for people with borderline personality disorder. METHOD: This was a multicenter, double-blind, placebo-controlled randomized trial. Between July 2013 and November 2016, the authors recruited 276 people age 18 or over who met diagnostic criteria for borderline personality disorder. Individuals with coexisting bipolar affective disorder or psychosis, those already taking a mood stabilizer, and women at risk of pregnancy were excluded...
April 6, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29618019/differential-expression-of-synapsin-i-and-ii-upon-treatment-by-lithium-and-valproic-acid-in-various-brain-regions
#6
Hetshree Joshi, Roohie Sharma, Shreya Prashar, Joella Ho, Sharon Thomson, Ram Mishra
Introduction: Due to the heterogeneity of psychiatric illnesses and overlapping mechanisms, patients with psychosis are differentially responsive to pharmaceutical drugs. In addition to having therapeutic effects for schizophrenia and bipolar disorder, antipsychotics and mood stabilizers have many clinical applications and are used unconventionally due to their direct and indirect effects on neurotransmitters. Synapsins, a family of neuronal phosphoproteins, play a key regulatory role in neurotransmitter release at synapses...
March 30, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29618013/fgf21-is-associated-with-metabolic-effects-and-treatment-response-in-depressed-bipolar-ii-disorder-patients-treated-with-valproate
#7
Hui Hua Chang, Po See Chen, Yung Wen Cheng, Tzu-Yun Wang, Yen Kuang Yang, Ru-Band Lu
Background: Patients with bipolar disorder are at high risk of metabolic disturbance after mood stabilizer treatment. However, the mediators linking the two conditions remain unknown. In this study, we investigated whether fibroblast growth factor-21 (FGF21) was associated with metabolic effects and treatment response in depressed bipolar disorder patients. Methods: We recruited 78 community-dwelling controls and 137 bipolar disorder patients; the latter were interviewed using the Chinese Version of the Modified Schedule of Affective Disorder and Schizophrenia-Life Time...
April 1, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29616434/control-charts-for-monitoring-mood-stability-as-a-predictor-of-severe-episodes-in-patients-with-bipolar-disorder
#8
Maria D L A Vazquez-Montes, Richard Stevens, Rafael Perera, Kate Saunders, John R Geddes
BACKGROUND: Recurrent mood episodes and subsyndromal mood instability cause substantial disability in patients with bipolar disorder. Early identification of mood episodes enabling timely mood stabilization is an important clinical goal. This study investigates the ability of control chart methodology to predict manic and/or depressive episodes by applying Shewhart's control rules to weekly self-reported scores from mania and depression questionnaires. METHODS: Shewhart's control rules were applied to weekly self-reported scores from the Altman Self-Rating Mania Scale (ASRM) and the Quick Inventory of Depressive Symptomatology-Self-Report (QIDS) collected from 2001 to 2012 as part of the OXTEXT programme...
April 4, 2018: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/29614641/neuropsychiatric-symptoms-and-the-diagnostic-stability-of-mild-cognitive-impairment
#9
Michael A Sugarman, Michael L Alosco, Yorghos Tripodis, Eric G Steinberg, Robert A Stern
BACKGROUND: Mild cognitive impairment (MCI) is an intermediate diagnosis between normal cognition (NC) and dementia, including Alzheimer's disease (AD) dementia. However, MCI is heterogeneous; many individuals subsequently revert to NC while others remain stable at MCI for several years. Identifying factors associated with this diagnostic instability could assist in defining clinical populations and determining cognitive prognoses. OBJECTIVE: The current study examined whether neuropsychiatric symptoms could partially account for the temporal instability in cognitive diagnoses...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29607445/a-review-on-the-general-stability-of-mood-disorder-diagnoses-along-the-lifetime
#10
REVIEW
Diego de la Vega, Ana Piña, Francisco J Peralta, Sam A Kelly, Lucas Giner
PURPOSE OF REVIEW: The purpose of this review is to review the most recent literature regarding diagnostic stability of mood disorders, focusing on epidemiological, clinical-psychopathological, and neurobiological data for unipolar and bipolar affective disorders. RECENT FINDINGS: Unipolar depression follows a chronic course in at least half of all cases and presents a considerable diagnostic stability across all age ranges. Studies using latent class analysis are allowing improved profiling of depressive subtypes and assessment of their prevalence...
April 2, 2018: Current Psychiatry Reports
https://www.readbyqxmd.com/read/29596721/substance-use-comorbidity-in-bipolar-disorder-a-qualitative-review-of-treatment-strategies-and-outcomes
#11
REVIEW
Alexandra K Gold, Michael W Otto, Thilo Deckersbach, Louisa G Sylvia, Andrew A Nierenberg, Gustavo Kinrys
BACKGROUND AND OBJECTIVES: Substance use disorders (SUDs) are present in up to 70% of patients with bipolar disorder (BD) and contribute to high rates of disability, morbidity, and treatment non-adherence. Despite this prevalence, few trials have investigated targeted psychosocial interventions for comorbid BD and SUDs. METHODS: Using PubMed and PsycINFO, we conducted a search of the literature up to January 2018 for psychosocial interventions targeted to patients with comorbid BD and SUDs...
April 2018: American Journal on Addictions
https://www.readbyqxmd.com/read/29574303/prevalence-and-correlates-of-antipsychotic-polypharmacy-in-hong-kong
#12
Stephanie Lock Man Lung, Ho Ming Edwin Lee, Yu Hai Eric Chen, Kit Wa Sherry Chan, Wing Chung Chang, Lai Ming Christy Hui
BACKGROUND: Antipsychotic polypharmacy (APP) remains a common practice despite inconclusive empirical evidence of additional efficacy and potential exacerbation of side effects. Previous studies suggest APP rate is notably high in East Asia. This paper aims to investigate the prevalence and correlates of APP in Hong Kong. METHOD: This was a cross-sectional study of 728 patients with psychosis. The demographics and clinical information, including age, gender, diagnosis, hospitalization history, and medication were collected...
March 10, 2018: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29550856/association-of-the-centers-for-medicare-medicaid-services-national-partnership-to-improve-dementia-care-with-the-use-of-antipsychotics-and-other-psychotropics-in-long-term-care-in-the-united-states-from-2009-to-2014
#13
Donovan T Maust, H Myra Kim, Claire Chiang, Helen C Kales
Importance: The Centers for Medicare & Medicaid Services' National Partnership to Improve Dementia Care in Nursing Homes (hereafter referred to as the partnership) was established to improve the quality of care for patients with dementia, measured by the rate of antipsychotic prescribing. Objective: To determine the association of the partnership with trends in prescribing of antipsychotic and other psychotropic medication among older adults in long-term care...
March 17, 2018: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29549608/weighing-the-risks-the-management-of-bipolar-disorder-during-pregnancy
#14
REVIEW
Michael Thomson, Verinder Sharma
PURPOSE OF REVIEW: The management of bipolar disorder during pregnancy requires difficult treatment decisions be made by both women and their clinicians. There is little consensus on management despite the high prevalence of bipolar disorder in reproductive-aged women. In this review, we have summarized the available literature and discuss the balancing of risks associated with treatment decisions. RECENT FINDINGS: Cohort studies have shown a high relapse rate in women with bipolar disorder who discontinue mood-stabilizing medications...
March 17, 2018: Current Psychiatry Reports
https://www.readbyqxmd.com/read/29545118/cognitive-benefits-of-lithium-chloride-in-app-ps1-mice-are-associated-with-enhanced-brain-clearance-of-%C3%AE-amyloid
#15
Yijun Pan, Jennifer L Short, Stephanie A Newman, Kwok H C Choy, Durgesh Tiwari, Christopher Yap, Danielle Senyschyn, William A Banks, Joseph A Nicolazzo
Epidemiological evidence suggests that people with bipolar disorder prescribed lithium exhibit a lower risk of Alzheimer's disease (AD) relative to those prescribed other mood-stabilizing medicines. Lithium chloride (LiCl) reduces brain β-amyloid (Aβ) levels, and the brain clearance of Aβ is reduced in AD. Therefore, the purpose of this study was to assess whether the cognitive benefits of LiCl are associated with enhanced brain clearance of exogenously-administered Aβ. The brain clearance of intracerebroventricularly (icv) administered125 I-Aβ42 was assessed in male Swiss outbred mice administered daily oral NaCl or LiCl (300 mg/kg for 21 days)...
March 12, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29543103/meta-analysis-and-review-of-dopamine-agonists-in-acute-episodes-of-mood-disorder-efficacy-and-safety
#16
Bruno Romeo, Lisa Blecha, Katia Locatelli, Amine Benyamina, Catherine Martelli
The objective of this meta-analysis is to assess the efficacy and safety of partial and complete dopamine agonists in the treatment of acute mood disorder episodes. Randomized, double-blind and placebo-controlled trials of dopamine agonists in the treatment of acute mood disorder episodes were identified in the MEDLINE and PsycINFO databases and included in the meta-analysis. In monotherapy of mania, improved remission rates were found for cariprazine (odds ratio (OR): 2.08, P < 0.01) and for high-dose aripiprazole (OR: 3...
April 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29527636/possible-pharmacodynamic-and-pharmacokinetic-drug-drug-interactions-that-are-likely-to-be-clinically-relevant-and-or-frequent-in-bipolar-disorder
#17
REVIEW
Jose de Leon, Edoardo Spina
PURPOSE OF REVIEW: Patients with bipolar disorder are frequently treated with polypharmacy. This article should provide clinicians with an understanding of how polypharmacy can contribute to pharmacokinetic and pharmacodynamic drug-drug interactions (DDIs). RECENT FINDINGS: The pharmacokinetics and pharmacodynamics of lithium and other mood stabilizers (valproate, lamotrigine, carbamazepine, oxcarbazepine, and eslicarbazepine), antipsychotics, and selective serotonin reuptake inhibitors (SSRIs) were reviewed and summarized in the first four tables describing their pharmacokinetic and pharmacodynamic mechanisms...
March 12, 2018: Current Psychiatry Reports
https://www.readbyqxmd.com/read/29525480/safety-of-reassessment-and-release-practice-for-mental-health-patients-boarded-in-the-emergency-department
#18
Sangil Lee, Karisa K Harland, Morgan Bobb Swanson, Sara Lawson, Elijah Dahlstrom, Lance Clemson, Elaine Himadi
OBJECTIVES: Among emergency department (ED) mental health and substance abuse (MHSA) patients, we sought to compare mortality and healthcare utilization by ED discharge disposition and inpatient bed request status. METHODS: A retrospective cohort study of 492 patients was conducted at a single University ED. We reviewed three groups of MHSA patients including ED patients that were admitted, ED patients with a bed request that were discharged from the ED, and ED patients with no bed request that were discharged from the ED...
February 27, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29524749/differential-prevalence-and-demographic-and-clinical-correlates-of-antidepressant-use-in-american-bipolar-i-versus-bipolar-ii-disorder-patients
#19
Farnaz Hooshmand, Dennis Do, Saloni Shah, Anda Gershon, Dong Yeon Park, Hyun Kim, Laura D Yuen, Bernardo Dell'Osso, Po W Wang, Terence A Ketter, Shefali Miller
AIMS: Antidepressant use is controversial in bipolar disorder (BD) due to questionable efficacy/psychiatric tolerability. We assessed demographic/clinical characteristics of baseline antidepressant use in BD patients. METHODS: Prevalence and correlates of baseline antidepressant use in 503 BD I and BD II outpatients referred to the Stanford Bipolar Clinic during 2000-2011 were assessed with the Systematic Treatment Enhancement Program for BD (STEP-BD) Affective Disorders Evaluation...
February 27, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29517871/-chirurgie-bariatrique-%C3%A2-sleeve%C3%A2-gastrectomie-intoxication-au-lithium
#20
R Niessen, T Sottiaux, J F Adam, A Schillaci, F Lejeune
Since many years a correlation between neuropsychiatric disorders and eating disorders resulting in obesity is well established. According to different studies, 1.2 - 4 % of patients scheduled for bariatric surgery are taking lithium as a mood stabilizer treatment for bipolar disorder. We are presenting a case of lithium toxicity after vertical sleeve gastrectomy surgery in a 40 years-old female. The patient developed severe neurological and renal signs needing an intensive care unit admission and continuous veno-venous hemodiafiltration...
February 2018: Revue Médicale de Liège
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