keyword
MENU ▼
Read by QxMD icon Read
search

Mood stabilizers

keyword
https://www.readbyqxmd.com/read/27935747/treatment-decision-making-capacity-in-children-and-adolescents-hospitalized-for-an-acute-mental-disorder-the-role-of-cognitive-functioning-and-psychiatric-symptoms
#1
Gabriele Mandarelli, Ugo Sabatello, Elisa Lapponi, Giulia Pace, Mauro Ferrara, Stefano Ferracuti
OBJECTIVE: This study was conducted to assess treatment decision-making capacity (TDMC) in a child and adolescent psychiatric sample and to verify possible associations between TDMC, psychiatric symptom severity, and cognitive functioning. METHODS: Twenty-two consecutively recruited patients hospitalized for an acute mental disorder, aged 11-18 years, underwent measurement of TDMC by the MacArthur Competence Assessment Tool for Treatment (MacCAT-T). The MacCAT-T interview focused on patients' current treatment, which comprised second-generation antipsychotics (45...
December 9, 2016: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/27933713/antipsychotic-adjunctive-therapy-to-mood-stabilizers-and-1-year-rehospitalization-rates-in-bipolar-disorder-a-cohort-study
#2
Eldar Hochman, Amir Krivoy, Ayal Schaffer, Abraham Weizman, Avi Valevski
OBJECTIVES: Antipsychotic adjunctive therapy to mood stabilizers (MSs) may improve relapse prevention; however, only a few naturalistic studies, reflecting more generalizable bipolar disorder (BD) samples, support this notion. We compared the 1-year rehospitalization rates of manic patients with bipolar I disorder (BD-I) who were discharged with MS (lithium or valproate) monotherapy or with adjunctive atypical or typical antipsychotic therapy. METHODS: A total of 201 patients with BD-I who were hospitalized with manic episodes between 2005 and 2013 were retrospectively followed for 1-year rehospitalization rates according to treatment at discharge: MS monotherapy, MS with atypical antipsychotics, and MS with typical antipsychotics...
December 9, 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/27931904/effect-of-lithium-on-thyroid-function-in-adolescents-with-mood-disorder
#3
Rati Ranjan Sethy, Vinod Kumar Sinha
BACKGROUND: The purpose of the study was to determine thyroid gland volume and the frequency of thyroid dysfunction by using ultrasonography and laboratory parameters (TSH, T3, and T4) in long term lithium treated adolescent patients with mood disorder. METHODOLOGY: In a cross-sectional study, we performed ultrasonography and thyroid function test in 30 adolescent patients on long-term lithium treatment for mood disorder. Patients with adequate serum lithium levels for one year or more were taken for the study...
December 2016: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/27929341/personality-stability-from-age-14-to-age-77-years
#4
Mathew A Harris, Caroline E Brett, Wendy Johnson, Ian J Deary
There is evidence for differential stability in personality trait differences, even over decades. The authors used data from a sample of the Scottish Mental Survey, 1947 to study personality stability from childhood to older age. The 6-Day Sample (N = 1,208) were rated on six personality characteristics by their teachers at around age 14. In 2012, the authors traced as many of these participants as possible and invited them to take part in a follow-up study. Those who agreed (N = 174) completed a questionnaire booklet at age 77 years, which included rating themselves and asking someone who knew them well to rate them on the same 6 characteristics on which they were rated in adolescence...
December 2016: Psychology and Aging
https://www.readbyqxmd.com/read/27922641/ip3-accumulation-and-or-inositol-depletion-two-downstream-lithium-s-effects-that-may-mediate-its-behavioral-and-cellular-changes
#5
Y Sade, L Toker, N Z Kara, H Einat, S Rapoport, D Moechars, G T Berry, Y Bersudsky, G Agam
Lithium is the prototype mood stabilizer but its mechanism is still unresolved. Two hypotheses dominate-the consequences of lithium's inhibition of inositol monophosphatase at therapeutically relevant concentrations (the 'inositol depletion' hypothesis), and of glycogen-synthase kinase-3. To further elaborate the inositol depletion hypothesis that did not decisively determine whether inositol depletion per se, or phosphoinositols accumulation induces the beneficial effects, we utilized knockout mice of either of two inositol metabolism-related genes-IMPA1 or SMIT1, both mimic several lithium's behavioral and biochemical effects...
December 6, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27914246/tract-based-analysis-of-white-matter-integrity-in-psychotic-and-nonpsychotic-bipolar-disorder
#6
Andrew Ji, Douglass Godwin, Jerrel Rutlin, Sridhar Kandala, Joshua S Shimony, Daniel Mamah
BACKGROUND: At least 50% of individuals with bipolar disorder (BD) present with psychosis during their lifetime. Psychotic symptoms have sometimes been linked to specific genetic and phenotypic markers. This study aims to explore potential differences between bipolar disorder subtypes by measuring white matter integrity of the brain and relationships with clinical measures. METHODS: Diffusion tensor imaging and clinical measures were acquired from 102 participants, grouped as psychotic bipolar disorder (PBD) (n=48), non-psychotic bipolar disorder (NBD) (n=24), and healthy controls (n=30)...
November 27, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27906413/comparison-of-psychodrug-prescription-patterns-in-patients-diagnosed-with-bipolar-disorder-and-addiction
#7
Diego Barral, Fátima Barral, Nuria Cruz, Juan D Molina, Victoria Sánchez, Teresa Rosique
OBJECTIVE: To describe if there are differences in the prescription of psychodrug at discharge between bipolar disorder patients with or without addiction. METHODS: We review all the psychotropic drugs dispensed to inpatients of a brief hospitalization psychiatric unit diagnosed as having bipolar disorder at time of discharge. We recluted 225 patients over 18 years old on their last manic episode, between the year 2000 and 2010. We classify them according to the comorbid presence or not of a substance abuse or dependence disorder...
November 2016: Actas Españolas de Psiquiatría
https://www.readbyqxmd.com/read/27902528/increased-brain-lactate-during-depressive-episodes-and-reversal-effects-by-lithium-monotherapy-in-drug-naive-bipolar-disorder-a-3-t-1h-mrs-study
#8
Rodrigo Machado-Vieira, Marcus V Zanetti, Maria C Otaduy, Rafael T De Sousa, Marcio G Soeiro-de-Souza, Alana C Costa, Andre F Carvalho, Claudia C Leite, Geraldo F Busatto, Carlos A Zarate, Wagner F Gattaz
OBJECTIVE: Mitochondrial dysfunction and energy metabolism impairment are key components in the pathophysiology of bipolar disorder (BD) and may involve a shift from aerobic to anaerobic metabolism. Measurement of brain lactate in vivo using proton magnetic resonance spectroscopy (H-MRS) represents an important tool to evaluate mitochondrial and metabolic dysfunction during mood episodes, as well as to monitor treatment response. To date, very few studies have quantified brain lactate in BD...
November 28, 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27900735/electronic-monitoring-of-self-reported-mood-the-return-of-the-subjective
#9
REVIEW
Abigail Ortiz, Paul Grof
This narrative review describes recent developments in the use of technology for utilizing the self-monitoring of mood, provides some relevant background, and suggests some promising directions. Subjective experience of mood is one of the valuable sources of information about the state of an integrated mind/brain system. During the past century, psychiatry and psychology moved away from subjectivity, emphasizing external observation, precise measurement, and laboratory techniques. This shift, however, provided only a limited improvement in the understanding of mood disorders, and it appears that self-monitoring of mood has the potential to enrich our knowledge, particularly when combined with the advances in technology...
December 2016: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/27892736/therapeutics-of-postpartum-depression
#10
Michael Thomson, Verinder Sharma
Postpartum depression is a prevalent disorder affecting many women of reproductive age. Despite increasing public awareness, it is frequently underdiagnosed and undertreated leading to significant maternal morbidity and adverse child outcomes. When identified, postpartum depression is usually treated as major depressive disorder. Many studies have identified the postpartum as a period of high risk for first presentations and relapses of bipolar disorder. Areas Covered: This article reviews the acute and prophylactic treatment of postpartum major depressive disorder, bipolar depression and major depressive disorder with mixed features...
November 28, 2016: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/27889598/association-between-antipsychotic-drug-use-and-cataracts-in-patients-with-bipolar-disorder-a-population-based-nested-case-control-study
#11
Che-Sheng Chu, Po-Han Chou, Yi-Huei Chen, Min-Wei Huang, Min-Yen Hsu, Tsuo-Hung Lan, Ching-Heng Lin
BACKGROUND: No previous study has focused on the association between use of antipsychotic drugs and the development of cataracts in patients with bipolar disorder (BD); hence, we aimed to examine this association in the present study. METHODS: We conducted a retrospective nested case-control study using data from the National Health Insurance Database of Taiwan between 2000 and 2011. A total of 3292 BD patients, 1684 with cataracts and 1608 controls matched for age, sex, and index date, were included...
November 19, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27888528/hormone-related-migraine-headaches-and-mood-disorders-treatment-with-estrogen-stabilization
#12
Julia K Warnock, Lawrence J Cohen, Harvey Blumenthal, Jordan E Hammond
Since estrogens and the trigeminal system are inherently linked, prescribers who are treating a woman with a hormonally-related mood disorder and migraine headachesshould consider hormonal options to optimize the patient's treatment. This paper will discuss the interrelationships of estrogen, serotonin, and the trigeminal system as they relate to menstrual migraine occurrence and hormone-related mood symptoms. In addition, clinical examples are provided to facilitate the prescribers treating women during reproductive transitions in which declining estrogens are related to their suffering...
November 26, 2016: Pharmacotherapy
https://www.readbyqxmd.com/read/27875917/campania-region-italy-spontaneous-reporting-system-and-preventability-assessment-through-a-case-by-case-approach-a-pilot-study-on-psychotropic-drugs
#13
Maurizio Sessa, Concetta Rafaniello, Liberata Sportiello, Annamaria Mascolo, Cristina Scavone, Alessandra Maccariello, Teresa Iannaccone, Michele Fabrazzo, Liberato Berrino, Francesco Rossi, Annalisa Capuano
OBJECTIVE: We conducted the first pilot Italian study to assess the preventability of adverse drug reactions involving psychotropic drugs reported through spontaneous reporting system from 01/07/2012 to 31/12/2014 in Campania Region. METHODS: Preventability was assessed, case-by-case, using an adapted version of the P-method. The evaluation was performed only for those reports that had, as suspected drug, antipsychotics, mood stabilizers, antidepressants, anxiolytic and/or sedative-hypnotic...
December 2016: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/27872683/safe-and-effective-sofosbuvir-based-therapy-in-patients-with-mental-health-disease-on-hepatitis-c-virus-treatment
#14
Lydia Shuk Yee Tang, Jack Masur, Zayani Sims, Amy Nelson, Anu Osinusi, Anita Kohli, Sarah Kattakuzhy, Michael Polis, Shyam Kottilil
AIM: To study impact of baseline mental health disease on hepatitis C virus (HCV) treatment; and Beck's Depression Inventory (BDI) changes with sofosbuvir- and interferon-based therapy. METHODS: This is a retrospective cohort study of participants from 5 studies enrolled from single center trials conducted at the Clinical Research Center of the National Institutes of Health, Bethesda, MD, United States. All participants were adults with chronic HCV genotype 1 infection and naïve to HCV therapy...
November 8, 2016: World Journal of Hepatology
https://www.readbyqxmd.com/read/27872261/comorbid-diabetes-and-depression-in-a-national-sample-of-adults-with-psychosis
#15
Debra L Foley, Andrew Mackinnon, Vera A Morgan, David J Castle, Anna Waterreus, Cherrie A Galletly
OBJECTIVE: People with psychosis have an elevated risk of depression and diabetes but no large-scale study has characterized their relationship. We aimed to assess this association and to evaluate possible explanatory factors. METHODS: Analysis of cross-sectional data from a national sample of 1155 people with psychosis who gave a fasting blood sample and could be tested for diabetes mellitus. The association between current diabetes mellitus and current depression was estimated using logistic regression, adjusted for age, sex and current psychotropic medication...
November 21, 2016: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/27871720/-guidelines-for-the-prescription-of-mood-stabilizers-for-adolescents-a-literature-review
#16
G Munch, N Godart
INTRODUCTION: Adolescence is a unique phase of the human developmental process. In adolescents, psychotropic medications may have different efficacy and tolerance profiles compared to those at other stages of the lifespan. Mood stabilizers are a complex pharmacological category including lithium, some anticonvulsants, and some second generation antipsychotics. Focusing on this class of pharmacological agents, we aim to answer the following questions: in which indications and according to which modalities should mood stabilizers be prescribed during adolescence? METHODS: Information was sought from the websites of the French Haute Autorité de santé (HAS) and Agence nationale de sécurité du médicament et des produits de santé (ANSM), the American Food and Drug Administration (FDA) and the British National Institute for Health and Clinical Excellence (NICE)...
November 18, 2016: L'Encéphale
https://www.readbyqxmd.com/read/27870504/chronic-licl-pretreatment-suppresses-thrombin-stimulated-intracellular-calcium-mobilization-through-trpc3-in-astroglioma-cells
#17
Takuji Uemura, Marty Green, Jerry J Warsh
OBJECTIVES: Transient receptor potential canonical type 3 (TRPC3) channels are activated in B lymphoblast cell lines from patients with bipolar disorder (BD), and its expression is reduced by chronic lithium treatment, implicating TRPC3 in the intracellular calcium (Ca(2+) ) dyshomeostasis of BD. Thrombin, via a protease-activated receptor, moderates Ca(2+) signaling and TRPC3 in astrocytes, and also cell proliferation. We examined whether lithium pretreatment attenuates thrombin-stimulated TRPC3 expression and function in astrocytes, and levels of the calcium-binding peptide, S100B, which is expressed mainly in these cells...
November 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/27867948/supra-therapeutic-plasma-concentrations-of-haloperidol-induce-moderate-inhibition-of-lipopolysaccharide-induced-interleukin-8-release-in-human-monocytes
#18
Herbert Bosshart
BACKGROUND: The clinical use of antipsychotics and mood-stabilizing drugs with proven efficacy is largely determined by the occurrence of treatment-emergent adverse events and routine clinical chemistry and haematology data, which together define the safety and tolerability profile of these psychopharmaceuticals. Whereas the effects of mood-stabilizing drugs on functional properties of blood cells have been poorly investigated, the effects of antipsychotics have received more attention...
October 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27858347/serum-concentrations-of-mood-stabilizers-are-associated-with-memory-but-not-other-cognitive-domains-in-psychosis-spectrum-disorders-explorative-analyses-in-a-naturalistic-setting
#19
Nils Eiel Steen, Monica Aas, Carmen Simonsen, Ingrid Dieset, Martin Tesli, Mari Nerhus, Erlend Gardsjord, Ragni Mørch, Ingrid Agartz, Ingrid Melle, Anja Vaskinn, Olav Spigset, Ole A Andreassen
BACKGROUND: Mood stabilizers like lithium and anticonvulsants are used in bipolar and related psychotic disorders. There is a lack of knowledge of the relationship of these medications and cognition in the psychosis spectrum. We studied the association between serum concentration of mood stabilizers and cognitive performance in a well-characterized sample of bipolar and schizophrenia spectrum disorders. METHODS: Serum concentrations of valproate, lamotrigine, and lithium were analyzed for associations to performance on neuropsychological tests in six cognitive domains in individuals with bipolar disorder (n = 167) and in a combined sample of individuals with bipolar or schizophrenia spectrum disorders (n = 217)...
December 2016: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/27852967/-results-of-investigations-on-the-association-between-lithium-levels-in-drinking-water-and-suicidal-behaviour-in-the-population-a-narrative-review
#20
Anna Hidvégi, Zoltán Rihmer, Péter Döme
INTRODUCTION: The risk of suicide is determined by the interplay of several interrelated factors from which psychiatric (especially affective) disorders are the most powerful predictors. Lithium, a mood stabilizer (which is also used to augment the efficacy of antidepressant therapy) has a well-established antisuicidal effect. In the last decades several studies investigated whether there is an association between the amount of lithium in tap water and suicide risk in the population. METHODS: A PubMed search was conducted to identify papers investigated the association between lithium levels in drinking water and suicide risk of the population...
2016: Psychiatria Hungarica: A Magyar Pszichiátriai Társaság Tudományos Folyóirata
keyword
keyword
58887
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"