keyword
https://read.qxmd.com/read/38537154/the-future-of-liver-transplantation
#1
JOURNAL ARTICLE
Sandy Feng, Garrett R Roll, Foad J Rouhani, Alberto Sanchez Fueyo
Over the last 50 years, liver transplantation has evolved into a procedure routinely performed in many countries worldwide. Those able to access this therapy frequently experience a miraculous risk-benefit ratio since, particularly if they face imminently life threatening disease. Over the decades, the success of liver transplantation, with dramatic improvements in early post-transplant survival, has aggressively driven demand. However, in spite of the emergence of living donors to augment deceased donors as a source of organs, supply has lagged far behind demand...
March 27, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38537086/effect-of-dexmedetomidine-on-the-incidence-of-postoperative-acute-kidney-injury-in-living-donor-liver-transplantation-recipients-a-randomized-controlled-trial
#2
JOURNAL ARTICLE
Hye-Mee Kwon, Sa-Jin Kang, Sang-Bin Han, Jae Hwan Kim, Sung-Hoon Kim, In-Gu Jun, Jun-Gol Song, Gyu-Sam Hwang
BACKGROUND: Acute kidney injury (AKI) is one of the most common complications after living-donor liver transplantation (LDLT) that has great impact on recipient and graft outcomes. Dexmedetomidine is reported to decrease the incidence of AKI. In the current study, we investigated whether intraoperative dexmedetomidine infusion would reduce the AKI following LDLT. MATERIAL AND METHODS: In total, 205 adult patients undergoing elective LDLT were randomly assigned to the dexmedetomidine group (n=103) or the control group (n=102)...
April 3, 2024: International Journal of Surgery
https://read.qxmd.com/read/38537062/late-cytomegalovirus-disease-after-hematopoietic-cell-transplantation-significance-of-novel-transplantation-techniques
#3
JOURNAL ARTICLE
Alicja Sadowska-Klasa, Sezen Özkök, Hu Xie, Wendy M Leisenring, Danniel Zamora, Sachiko Seo, Jordan Sheldon, Stephanie J Lee, Keith R Jerome, Margaret L Green, Michael J Boeckh
Pre-emptive therapy (PET) and letermovir prophylaxis are effective in preventing CMV disease within the first 100 days after allogeneic hematopoietic cell transplantation (HCT) but are associated with late-onset CMV disease. We retrospectively examined the clinical manifestations, risk factors, prevention algorithm, and outcome of late CMV disease in CMV seropositive day 100 survivors transplanted between 2001-2017 (PET cohort) and 2018-2021 (letermovir cohort). There were 187 episodes of late CMV disease among 2469 day 100 survivors and the estimated cumulative incidence of first late CMV disease was 6...
March 27, 2024: Blood Advances
https://read.qxmd.com/read/38536795/why-do-people-sell-their-kidneys-a-thematic-synthesis-of-qualitative-evidence
#4
JOURNAL ARTICLE
Bijaya Shrestha, Luechai Sringernyuang, Manash Shrestha, Binita Shrestha, Anuska Adhikari, Dev Ram Sunuwar, Shiva Raj Mishra, Bipin Adhikari
Globally, demands for the kidneys have surpassed supply both living and deceased donors. High demands relative to the availability have made the kidney one of the most saleable human organs. The main objective was to explore the drivers of kidney selling. Literature related to kidney selling and its drivers was explored in three databases including MEDLINE (PubMed), Scopus (Elsevier), and JSTOR covering the period from 1987 to 2022. A total of 15 articles were selected, which underwent thematic analysis. Investigators independently assessed the articles for relevance and study quality to synthesize the data...
2024: PLOS Glob Public Health
https://read.qxmd.com/read/38536767/a-halogen-bonding-2-rotaxane-shuttle-for-chloride-selective-optical-sensing
#5
JOURNAL ARTICLE
Hui Min Tay, Andrew Docker, Andrew Taylor, Paul D Beer
The first example of a [2]rotaxane shuttle capable of selective optical sensing of chloride anions over other halides is reported. The rotaxane was synthesised via a chloride ion template-directed cyclisation of an isophthalamide macrocycle around a multi-station axle containing peripheral naphthalene diimide (NDI) stations and a halogen bonding (XB) bis(iodotriazole) based station. Proton NMR studies indicate the macrocycle resides preferentially at the NDI stations in the free rotaxane, where it is stabilised by aromatic donor-acceptor charge transfer interactions between the axle NDI and macrocycle hydroquinone moieties...
March 27, 2024: Chemistry: a European Journal
https://read.qxmd.com/read/38536766/perfluoroalkylation-of-triarylamines-by-eda-complexes-and-ulterior-sensitized-6%C3%AF-electrocyclization-to-perfluoroalkylated-endo-carbazoles-mechanistic-and-photophysical-studies
#6
JOURNAL ARTICLE
Ivan E Romero, Sebastian Barata-Vallejo, Sergio M Bonesi, Al Postigo
Blue LEDs-irradiation of a mixture of N,N,N´,N´-tetramethylethylenediamine (TMEDA) and perfluoroalkyl iodides (RF-I) -Electron Donor Acceptor (EDA)-complex- in the presence of triphenylamines (TPAs) in an aqueous solvent mixture afforded mono-perfluoroalkylated triphenylamines (RF-TPA) in good yields. These RF-TPA were further subjected to acetone-sensitized [6π]-electrocyclization at 315 nm-irradiation affording exclusively perfluoroalkylated endo-carbazole derivatives (RF-CBz) in quantitative yields...
March 27, 2024: Chemistry: a European Journal
https://read.qxmd.com/read/38536628/evaluation-of-the-histologic-and-immunohistochemical-cd34-glutamine-synthetase-findings-in-idiopathic-non-cirrhotic-portal-hypertension-incph
#7
JOURNAL ARTICLE
Melek Büyük, Neslihan Berker, Doğu Vurallı Bakkaloğlu, İbrahim Volkan Şenkal, Zerrin Önal, Mine Güllüoğlu
AIM: Idiopathic non-cirrhotic portal hypertension (INCPH) is a vascular disorder of uncertain origin. Diagnosis can be challenging on liver biopsy. Despite diverse histomorphologic findings documented in literature, studies on the frequency of these findings are lacking. This study aims to assess both the histomorphologic features and the immunoexpression patterns of CD34 and glutamine synthetase (GS) in liver biopsies and searched for their contribution to the pathologic diagnosis of INCPH...
March 27, 2024: Hepatology International
https://read.qxmd.com/read/38536618/genome-constitution-and-evolution-of-elymus-atratus-poaceae-triticeae-inferred-from-cytogenetic-and-phylogenetic-analysis
#8
JOURNAL ARTICLE
Lu Tan, Dan-Dan Wu, Chang-Bing Zhang, Yi-Ran Cheng, Li-Na Sha, Xing Fan, Hou-Yang Kang, Yi Wang, Hai-Qin Zhang, Marcial Escudero, Yong-Hong Zhou
BACKGROUND: Elymus atratus (Nevski) Hand.-Mazz. is perennial hexaploid wheatgrass. It was assigned to the genus Elymus L. sensu stricto based on morphological characters. Its genome constitution has not been disentangled yet. OBJECTIVE: To identify the genome constitution and origin of E. atratus. METHODS: In this study, genomic in situ hybridization and fluorescence in situ hybridization, and phylogenetic analysis based on the Acc1, DMC1 and matK sequences were performed...
March 27, 2024: Genes & Genomics
https://read.qxmd.com/read/38536514/detection-of-anaplasma-spp-and-ehrlichia-spp-in-dogs-from-a-veterinary-teaching-hospital-in-italy-a-retrospective-study-2012-2020
#9
JOURNAL ARTICLE
Veronica Facile, Maria Chiara Sabetti, Andrea Balboni, Lorenza Urbani, Alessandro Tirolo, Martina Magliocca, Francesco Lunetta, Francesco Dondi, Mara Battilani
Anaplasma phagocytophilum, Anaplasma platys and Ehrlichia canis, responsible of diseases in dogs, are tick-borne pathogens with a proven or potential zoonotic role that have shown increasing prevalence worldwide. The aims of this retrospective study were to assess the frequency of Anaplasma spp. and Ehrlichia spp. exposure in dogs tested in a veterinary teaching hospital in Italy over a 9-year period, to compare the performance of the diagnostic tests used, to evaluate correlations with clinical data, and to genetically analyse the identified bacteria...
March 27, 2024: Veterinary Research Communications
https://read.qxmd.com/read/38536207/robust-red-absorbing-donor-acceptor-stenhouse-adduct-photoswitches
#10
JOURNAL ARTICLE
Abbey Meprathu Philip, Marie Erskov Krogh, Bo Wegge Laursen
Donor-Acceptor Stenhouse Adduct (DASA), a class of push-pull negative photochromes, has received large interest lately owing to its versatile synthesis, modularity and excellent photoswitching in solutions. From a technological perspective, it is imperative for this class of photoswitches to work robustly in solid state, e.g. thin films. We feature a molecular framework for the optimized design of DASAs by introducing a new thioindoline donor (D3) and assessing its performance against known 2nd generation indoline-based donors...
March 27, 2024: Chemistry: a European Journal
https://read.qxmd.com/read/38536122/investigating-the-potential-of-phenolic-compounds-and-carbohydrates-as-acceptor-substrates-for-levansucrasse-catalyzed-transfructosylation-reaction
#11
JOURNAL ARTICLE
Muriel Wong Min, Lan Liu, Salwa Karboune
This study characterizes the acceptor specificity of levansucrases (LSs) from Gluconobacter oxydans (LS1), Vibrio natriegens (LS2), Novosphingobium aromaticivorans (LS3), and Paraburkholderia graminis (LS4) using sucrose as fructosyl donor and selected phenolic compounds and carbohydrates as acceptors. Overall, V. natriegens LS2 proved to be the best biocatalyst for the transfructosylation of phenolic compounds. More than one fructosyl unit could be attached to fructosylated phenolic compounds. The transfructosylation of epicatechin by P...
March 27, 2024: Chembiochem: a European Journal of Chemical Biology
https://read.qxmd.com/read/38535991/photocatalytic-conversion-of-co-2-to-co-by-ru-ii-and-os-ii-octahedral-complexes-a-dft-tddft-study
#12
JOURNAL ARTICLE
Athanassios C Tsipis, Antonia A Sarantou
The reaction mechanisms of the photocatalytic reduction of CO2 to CO catalyzed by [(en)M(CO)3 Cl] complexes (M = Ru, Os, en = ethylenediamine) in the presence of triethanolamine (TEOA), R3 N (R = -CH2 CH2 OH), in DCM and DMF solvents, were studied by means of DFT/TDDFT electronic structure calculations. The geometric and free energy reaction profiles for two possible reaction pathways were calculated. Both reaction pathways studied, start with the 17e- , catalytically active intermediate, [(en)M(CO)3 ]˙+ generated from the first triplet excited state, T1 upon reductive quenching by TEOA which acts as a sacrificial electron donor...
March 27, 2024: Dalton Transactions: An International Journal of Inorganic Chemistry
https://read.qxmd.com/read/38535660/the-pd-ii-reduction-mechanisms-in-bacillus-megaterium-y-4-revealed-by-proteomic-analysis
#13
JOURNAL ARTICLE
Yuan Chen, Jiaxing Wang, Daidi Chen, Boxi Wang, Jinchuan Wu, Rongrong Liu, Qingxin Li
Many studies have been conducted on the microbial reduction of Pd (II) to palladium nanoparticles (Pd-NPs) due to the environmental friendliness, low cost, and the decreased toxicity of Pd (II) ions. In this study, we investigate the reduction mechanism of Pd (II) by Bacillus megaterium Y-4 through proteomics. The data are available via ProteomeXchange with identifier PXD049711. Our results revealed that B. megaterium Y-4 may use the endogenous electron donor (NAD(P)H) generated by nirB, tdh, and fabG and reductase to reduce Pd (II) to Pd-NPs...
March 12, 2024: Nanomaterials
https://read.qxmd.com/read/38535650/fast-growth-polymer-fullerene-bulk-heterojunction-thin-films-for-efficient-organic-photovoltaics
#14
JOURNAL ARTICLE
Daewon Chung, Chandran Balamurugan, Byoungwook Park, Hyeonryul Lee, Ilhyeon Cho, Chaerin Yoon, Soyeon Park, Yong-Ryun Jo, Joonhyeon Jeon, Soonil Hong, Sooncheol Kwon
The bulk-heterojunction (BHJ) system that uses a π-conjugated polymer as an electron donor, and a fullerene derivative as an electron acceptor, is widely used in organic solar cells (OSCs) to facilitate efficient charge separation and extraction. However, the conventional BHJ system still suffers from unwanted phase segregation caused by the existence of significant differences in surface energy between the two BHJ components and the charge extraction layer during film formation. In the present work, we demonstrate a sophisticated control of fast film-growth kinetics that can be used to achieve a uniform distribution of donor and acceptor materials in the BHJ layer of OSCs without undesirable phase separation...
March 11, 2024: Nanomaterials
https://read.qxmd.com/read/38535401/-wolbachia-infection-through-hybridization-to-enhance-an-incompatible-insect-technique-based-suppression-of-aedes-albopictus-in-eastern-spain
#15
JOURNAL ARTICLE
Maria Cholvi, María Trelis, Rubén Bueno-Marí, Messaoud Khoubbane, Rosario Gil, Antonio Marcilla, Riccardo Moretti
The emergence of insecticide resistance in arbovirus vectors is putting the focus on the development of new strategies for control. In this regard, the exploitation of Wolbachia endosymbionts is receiving increasing attention due to its demonstrated effectiveness in reducing the vectorial capacity of Aedes mosquitoes. Here, we describe the establishment of a naïve Wolbachia infection in a wild Aedes albopictus population of eastern Spain through a hybridization approach to obtain males capable of sterilizing wild females...
March 20, 2024: Insects
https://read.qxmd.com/read/38534926/haploidentical-hematopoietic-stem-cell-transplantation-for-patients-with-severe-aplastic-anemia-single-centre-experience
#16
Vered Stavi, Niranjan Khaire, Jeffrey H Lipton, Rajat Kumar
Severe aplastic anemia (SAA) is a life-threatening type of aplastic anemia for which allogeneic stem cell transplantation or immunosuppressive therapy are the principal treatment modalities. Only about 25-30% of patients have a matched sibling donor, and finding an unrelated donor in ethnic minorities is a challenge. The use of related haploidentical donor transplants in severe aplastic anemia is uncommon. We would like to report our experience with the first four patients who underwent haploidentical transplants for severe aplastic anemia...
February 26, 2024: Current Oncology
https://read.qxmd.com/read/38534880/successful-bone-marrow-transplantation-in-a-patient-with-acute-myeloid-leukemia-developed-from-severe-congenital-neutropenia-using-modified-chemotherapy-and-conditioning-regimen-for-leukemia
#17
Risa Matsumura, Shinji Mochizuki, Yusuke Morishita, Hiroko Hayakawa, Shuhei Karakawa, Hiroshi Kawaguchi, Satoshi Okada, Nobuyuki Hyakuna, Masao Kobayashi
Severe congenital neutropenia (SCN) is characterized by chronic neutropenia with recurrent infections from early infancy and a predisposition to myelodysplastic syndrome/acute myeloid leukemia (AML). Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative treatment for patients with SCN who develop myelodysplastic syndrome/AML. We report an 8-year-old girl with SCN carrying an ELANE mutation that had been refractory to granulocyte colony-stimulating factor. The patient experienced recurrent infections and then developed AML...
February 26, 2024: Hematology Reports
https://read.qxmd.com/read/38534794/exploring-transcriptional-regulation-of-beta-cell-sasp-by-brd4-associated-proteins-and-cell-cycle-control-protein-p21
#18
JOURNAL ARTICLE
Jasmine Manji, Jasmine Pipella, Gabriel Brawerman, Peter J Thompson
Type 1 diabetes (T1D) is a metabolic disease resulting from progressive autoimmune destruction of insulin-producing pancreatic beta cells. Although the majority of beta cells are lost in T1D, a small subset undergoes senescence, a stress response involving growth arrest, DNA damage response, and activation of a senescence-associated secretory phenotype (SASP). SASP in beta cells of the nonobese diabetic (NOD) mouse model of T1D and primary human islets is regulated at the level of transcription by bromodomain extra-terminal (BET) proteins, but the mechanisms remain unclear...
March 6, 2024: Epigenomes
https://read.qxmd.com/read/38534788/the-opposite-functions-of-cd30-ligand-isoforms
#19
JOURNAL ARTICLE
Ignat Printsev, Elyas Alalli, Janine Bilsborough
TNFSF8/CD30 ligand is a TNF superfamily member expressed on several major immune cell types, including activated monocytes, B, and T cells. The signaling of CD30 ligand through its cognate CD30 receptor has been shown to have effects on cell differentiation, cell death/survival, and cytokine production. The signaling pair has been implicated in hematopoietic malignancies and inflammatory disease, and a chemotherapy-CD30 antibody combination for the treatment of Hodgkin and other lymphomas has been developed...
March 21, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534530/analyzing-blood-cells-of-high-risk-myelodysplastic-syndrome-patients-using-interferometric-phase-microscopy-and-fluorescent-flow-cytometry
#20
JOURNAL ARTICLE
Itay Barnea, Lior Luria, Arik Girsault, Ofira Dabah, Matan Dudaie, Simcha K Mirsky, Drorit Merkel, Natan T Shaked
Myelodysplastic syndromes (MDSs) are a group of potentially deadly diseases that affect the morphology and function of neutrophils. Rapid diagnosis of MDS is crucial for the initiation of treatment that can vastly improve disease outcome. In this work, we present a new approach for detecting morphological differences between neutrophils isolated from blood samples of high-risk MDS patients and blood bank donors (BBDs). Using fluorescent flow cytometry, neutrophils were stained with 2',7'-dichlorofluorescin diacetate (DCF), which reacts with reactive oxygen species (ROS), and Hoechst, which binds to DNA...
March 6, 2024: Bioengineering
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