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Godelieve Meunier, Loic Ysebaert, Phi Linh Nguyen-Thi, Stéphane Lepretre, Anne Quinquenel, Jehan Dupuis, Richard Lemal, Thérèse Aurran, Cécile Tomowiak, Florence Cymbalista, Marie Sarah Dilhuydy, Annie Brion, Pierre Morel, Bruno Cazin, Véronique Leblond, Guillaume Cartron, Daniel Ré, Marie Christine Béné, Anne Sophie Michallet, Pierre Feugier
The mean age at diagnosis of chronic lymphocytic leukemia (CLL) is 72 years, with 22.8% of patients being older than 80 years. However, the elderly are underrepresented in clinical studies of CLL. We performed a retrospective study of CLL patients aged 80 years or older at the initiation of first-line therapy in hospitals affiliated with the French intergroup on CLL (French Innovative Leukemia Organization) between 2003 and 2013. Here, we describe the clinical and biological characteristics, treatment, and outcomes for 201 patients...
November 22, 2016: Hematological Oncology
Adriana G Ramirez, Margaret C Tracci, George J Stukenborg, Florence E Turrentine, Benjamin D Kozower, R Scott Jones
BACKGROUND: The Hospital Value-Based Purchasing Program measures value of care provided by participating Medicare hospitals and creates financial incentives for quality improvement and fosters increased transparency. Limited information is available comparing hospital performance across health care business models. STUDY DESIGN: The 2015 Hospital Value-Based Purchasing Program results were used to examine hospital performance by business model. General linear modeling assessed differences in mean total performance score, hospital case mix index, and differences after adjustment for differences in hospital case mix index...
October 2016: Journal of the American College of Surgeons
Vijay Ramaswamy, Thomas Hielscher, Stephen C Mack, Alvaro Lassaletta, Tong Lin, Kristian W Pajtler, David T W Jones, Betty Luu, Florence M G Cavalli, Kenneth Aldape, Marc Remke, Martin Mynarek, Stefan Rutkowski, Sridharan Gururangan, Roger E McLendon, Eric S Lipp, Christopher Dunham, Juliette Hukin, David D Eisenstat, Dorcas Fulton, Frank K H van Landeghem, Mariarita Santi, Marie-Lise C van Veelen, Erwin G Van Meir, Satoru Osuka, Xing Fan, Karin M Muraszko, Daniela P C Tirapelli, Sueli M Oba-Shinjo, Suely K N Marie, Carlos G Carlotti, Ji Yeoun Lee, Amulya A Nageswara Rao, Caterina Giannini, Claudia C Faria, Sofia Nunes, Jaume Mora, Ronald L Hamilton, Peter Hauser, Nada Jabado, Kevin Petrecca, Shin Jung, Luca Massimi, Massimo Zollo, Giuseppe Cinalli, László Bognár, Almos Klekner, Tibor Hortobágyi, Sarah Leary, Ralph P Ermoian, James M Olson, Jeffrey R Leonard, Corrine Gardner, Wieslawa A Grajkowska, Lola B Chambless, Jason Cain, Charles G Eberhart, Sama Ahsan, Maura Massimino, Felice Giangaspero, Francesca R Buttarelli, Roger J Packer, Lyndsey Emery, William H Yong, Horacio Soto, Linda M Liau, Richard Everson, Andrew Grossbach, Tarek Shalaby, Michael Grotzer, Matthias A Karajannis, David Zagzag, Helen Wheeler, Katja von Hoff, Marta M Alonso, Teresa Tuñon, Ulrich Schüller, Karel Zitterbart, Jaroslav Sterba, Jennifer A Chan, Miguel Guzman, Samer K Elbabaa, Howard Colman, Girish Dhall, Paul G Fisher, Maryam Fouladi, Amar Gajjar, Stewart Goldman, Eugene Hwang, Marcel Kool, Harshad Ladha, Elizabeth Vera-Bolanos, Khalida Wani, Frank Lieberman, Tom Mikkelsen, Antonio M Omuro, Ian F Pollack, Michael Prados, H Ian Robins, Riccardo Soffietti, Jing Wu, Phillipe Metellus, Uri Tabori, Ute Bartels, Eric Bouffet, Cynthia E Hawkins, James T Rutka, Peter Dirks, Stefan M Pfister, Thomas E Merchant, Mark R Gilbert, Terri S Armstrong, Andrey Korshunov, David W Ellison, Michael D Taylor
PURPOSE: Posterior fossa ependymoma comprises two distinct molecular variants termed EPN_PFA and EPN_PFB that have a distinct biology and natural history. The therapeutic value of cytoreductive surgery and radiation therapy for posterior fossa ependymoma after accounting for molecular subgroup is not known. METHODS: Four independent nonoverlapping retrospective cohorts of posterior fossa ependymomas (n = 820) were profiled using genome-wide methylation arrays. Risk stratification models were designed based on known clinical and newly described molecular biomarkers identified by multivariable Cox proportional hazards analyses...
July 20, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Deidre M Anglin, Florence Lui, Adriana Espinosa, Aleksandr Tikhonov, Lauren Ellman
AIM: Studies suggest strong ethnic identity generally protects against negative mental health outcomes associated with racial discrimination. In light of evidence suggesting racial discrimination may enhance psychosis risk in racial and ethnic minority (REM) populations, the present study explored the relationship between ethnic identity and attenuated positive psychotic symptoms (APPS) and whether ethnic identity moderates the association between racial discrimination and these symptoms...
January 28, 2016: Early Intervention in Psychiatry
Lionel Dany, Karine Baumstarck, Eric Dudoit, Florence Duffaud, Pascal Auquier, Sébastien Salas
BACKGROUND: The question whether euthanasia should be legalised has led to substantial public debate in France. The objective of this study in a sample of French physicians was to establish the potential determinants of a favourable opinion about euthanasia in general and when faced with a specific situation as embodied in the Humbert affair. METHODS: The study was a cross-sectional survey investigating two different samples of medical doctors: (1) those specialised in palliative care and affiliated to the French Society for Patient Accompaniment and Palliative Care; (2) medical interns (medical doctors in training course) in a French medical university (Marseille)...
2015: BMC Palliative Care
Xin Wang, Adrian M Dubuc, Vijay Ramaswamy, Stephen Mack, Deena M A Gendoo, Marc Remke, Xiaochong Wu, Livia Garzia, Betty Luu, Florence Cavalli, John Peacock, Borja López, Patryk Skowron, David Zagzag, David Lyden, Caitlin Hoffman, Yoon-Jae Cho, Charles Eberhart, Tobey MacDonald, Xiao-Nan Li, Timothy Van Meter, Paul A Northcott, Benjamin Haibe-Kains, Cynthia Hawkins, James T Rutka, Eric Bouffet, Stefan M Pfister, Andrey Korshunov, Michael D Taylor
Medulloblastoma comprises four distinct molecular variants with distinct genetics, transcriptomes, and outcomes. Subgroup affiliation has been previously shown to remain stable at the time of recurrence, which likely reflects their distinct cells of origin. However, a therapeutically relevant question that remains unanswered is subgroup stability in the metastatic compartment. We assembled a cohort of 12-paired primary-metastatic tumors collected in the MAGIC consortium, and established their molecular subgroup affiliation by performing integrative gene expression and DNA methylation analysis...
March 2015: Acta Neuropathologica
Cléa Bauvais, Séverine Zirah, Laurie Piette, Florence Chaspoul, Isabelle Domart-Coulon, Virginie Chapon, Philippe Gallice, Sylvie Rebuffat, Thierry Pérez, Marie-Lise Bourguet-Kondracki
The present study explored the bacteria of the sponge Spongia officinalis in a metal-polluted environment, using PCR-DGGE fingerprinting, culture-dependent approaches and in situ hybridization. The sponge samples collected over three consecutive years in the Western Mediterranean Sea contained high concentrations of zinc, nickel, lead and copper determined by ICP-MS. DGGE signatures indicated a sponge specific bacterial association and suggested spatial and temporal variations. The bacterial culturable fraction associated with S...
March 2015: Marine Environmental Research
Angelina Chemerys, Eric Pelletier, Corinne Cruaud, Florence Martin, Fabien Violet, Yves Jouanneau
Ring-hydroxylating dioxygenases (RHDs) play a crucial role in the biodegradation of a range of aromatic hydrocarbons found on polluted sites, including polycyclic aromatic hydrocarbons (PAHs). Current knowledge on RHDs comes essentially from studies on culturable bacterial strains, while compelling evidence indicates that pollutant removal is mostly achieved by uncultured species. In this study, a combination of DNA-SIP labeling and metagenomic sequence analysis was implemented to investigate the metabolic potential of main PAH degraders on a polluted site...
November 2014: Applied and Environmental Microbiology
Philippe Guerci, Florence Vial, Jérôme Feugeas, Marius Pop, Nour-Eddine Baka, Hervé Bouaziz, Marie-Reine Losser
OBJECTIVES: To determine the regional cerebral oxygen saturation of hemoglobin (rcSO2) in severe preeclamptic parturients exhibiting neurologic symptoms compared with healthy pregnant women (control) and to describe the effects of MgSO4 infusion on rcSO2 and cerebral and systemic hemodynamic variables. DESIGN: Prospective, observational study. SETTING: Obstetric critical care unit in a university-affiliated hospital. PATIENTS: Twenty severe preeclamptic parturients presenting with neurologic signs before any administration of MgSO4, and 20 control parturients...
November 2014: Critical Care Medicine
H Bjørn Nielsen, Mathieu Almeida, Agnieszka Sierakowska Juncker, Simon Rasmussen, Junhua Li, Shinichi Sunagawa, Damian R Plichta, Laurent Gautier, Anders G Pedersen, Emmanuelle Le Chatelier, Eric Pelletier, Ida Bonde, Trine Nielsen, Chaysavanh Manichanh, Manimozhiyan Arumugam, Jean-Michel Batto, Marcelo B Quintanilha Dos Santos, Nikolaj Blom, Natalia Borruel, Kristoffer S Burgdorf, Fouad Boumezbeur, Francesc Casellas, Joël Doré, Piotr Dworzynski, Francisco Guarner, Torben Hansen, Falk Hildebrand, Rolf S Kaas, Sean Kennedy, Karsten Kristiansen, Jens Roat Kultima, Pierre Léonard, Florence Levenez, Ole Lund, Bouziane Moumen, Denis Le Paslier, Nicolas Pons, Oluf Pedersen, Edi Prifti, Junjie Qin, Jeroen Raes, Søren Sørensen, Julien Tap, Sebastian Tims, David W Ussery, Takuji Yamada, Pierre Renault, Thomas Sicheritz-Ponten, Peer Bork, Jun Wang, Søren Brunak, S Dusko Ehrlich
Most current approaches for analyzing metagenomic data rely on comparisons to reference genomes, but the microbial diversity of many environments extends far beyond what is covered by reference databases. De novo segregation of complex metagenomic data into specific biological entities, such as particular bacterial strains or viruses, remains a largely unsolved problem. Here we present a method, based on binning co-abundant genes across a series of metagenomic samples, that enables comprehensive discovery of new microbial organisms, viruses and co-inherited genetic entities and aids assembly of microbial genomes without the need for reference sequences...
August 2014: Nature Biotechnology
Elcia M S Brito, Norberto Villegas-Negrete, Irene A Sotelo-González, César A Caretta, Marisol Goñi-Urriza, Claire Gassie, Florence Hakil, Yannick Colin, Robert Duran, Felix Gutiérrez-Corona, Hilda A Piñón-Castillo, Germán Cuevas-Rodríguez, Olaf Malm, João P M Torres, Anne Fahy, Georgina E Reyna-López, Rémy Guyoneaud
Los Azufres spa consists of a hydrothermal spring system in the Mexican Volcanic Axis. Five samples (two microbial mats, two mud pools and one cenote water), characterized by high acidity (pH between 1 and 3) and temperatures varying from 27 to 87 °C, were investigated for their microbial diversity by Terminal-Restriction Fragment Length Polymorphism (T-RFLP) and 16S rRNA gene library analyses. These data are the first to describe microbial diversity from Los Azufres geothermal belt. The data obtained from both approaches suggested a low bacterial diversity in all five samples...
March 2014: Extremophiles: Life Under Extreme Conditions
Marc Remke, Vijay Ramaswamy, John Peacock, David J H Shih, Christian Koelsche, Paul A Northcott, Nadia Hill, Florence M G Cavalli, Marcel Kool, Xin Wang, Stephen C Mack, Mark Barszczyk, A Sorana Morrissy, Xiaochong Wu, Sameer Agnihotri, Betty Luu, David T W Jones, Livia Garzia, Adrian M Dubuc, Nataliya Zhukova, Robert Vanner, Johan M Kros, Pim J French, Erwin G Van Meir, Rajeev Vibhakar, Karel Zitterbart, Jennifer A Chan, László Bognár, Almos Klekner, Boleslaw Lach, Shin Jung, Ali G Saad, Linda M Liau, Steffen Albrecht, Massimo Zollo, Michael K Cooper, Reid C Thompson, Oliver O Delattre, Franck Bourdeaut, François F Doz, Miklós Garami, Peter Hauser, Carlos G Carlotti, Timothy E Van Meter, Luca Massimi, Daniel Fults, Scott L Pomeroy, Toshiro Kumabe, Young Shin Ra, Jeffrey R Leonard, Samer K Elbabaa, Jaume Mora, Joshua B Rubin, Yoon-Jae Cho, Roger E McLendon, Darell D Bigner, Charles G Eberhart, Maryam Fouladi, Robert J Wechsler-Reya, Claudia C Faria, Sidney E Croul, Annie Huang, Eric Bouffet, Cynthia E Hawkins, Peter B Dirks, William A Weiss, Ulrich Schüller, Ian F Pollack, Stefan Rutkowski, David Meyronet, Anne Jouvet, Michelle Fèvre-Montange, Nada Jabado, Marta Perek-Polnik, Wieslawa A Grajkowska, Seung-Ki Kim, James T Rutka, David Malkin, Uri Tabori, Stefan M Pfister, Andrey Korshunov, Andreas von Deimling, Michael D Taylor
Telomerase reverse transcriptase (TERT) promoter mutations were recently shown to drive telomerase activity in various cancer types, including medulloblastoma. However, the clinical and biological implications of TERT mutations in medulloblastoma have not been described. Hence, we sought to describe these mutations and their impact in a subgroup-specific manner. We analyzed the TERT promoter by direct sequencing and genotyping in 466 medulloblastomas. The mutational distributions were determined according to subgroup affiliation, demographics, and clinical, prognostic, and molecular features...
December 2013: Acta Neuropathologica
Agnès Mihajlovski, Joël Doré, Florence Levenez, Monique Alric, Jean-François Brugère
The methanogenic diversity of the human intestinal microbiota has long been viewed as composed of two Methanobacteriales: Methanobrevibacter smithii and Methanosphaera stadtmanae. Recently, Mx-01, a new phylotype hypothesized to belong to a putative sixth methanogenic order, was recovered from human faeces. Here we examined the diversity and the distribution of methanogens among healthy people of three age groups by analysing mcrA and 16S rDNA clones. The mcrA analysis of ∼1200 clones revealed that the usual Methanobacteriales were present without any significant difference among adults and elderly (respectively 60% and 80% of carriers, n = 40, P = 0...
April 2010: Environmental Microbiology Reports
Ludovic Besaury, Florence Marty, Sylvaine Buquet, Valérie Mesnage, Gerard Muyzer, Laurent Quillet
Cultivation and molecular-based approaches were used to study microbial diversity in two Chilean marine sediments contaminated with high (835 ppm) and very high concentrations of copper (1,533 ppm). The diversity of cultivable bacteria resistant to copper was studied at oxic and anoxic conditions, focusing on sulfate-, thiosulfate-, and iron-reducing bacteria. For both sediments, the cultivable bacteria isolated at oxic conditions were mostly affiliated to the genus Bacillus, while at anoxic conditions the majority of the cultivable bacteria found were closely related to members of the genera Desulfovibrio, Sphingomonas, and Virgibacillus...
February 2013: Microbial Ecology
Romain Sonneville, Mariana Mirabel, David Hajage, Florence Tubach, Philippe Vignon, Pierre Perez, Sylvain Lavoué, Achille Kouatchet, Olivier Pajot, Armand Mekontso Dessap, Jean-Marie Tonnelier, Pierre-Edouard Bollaert, Jean-Pierre Frat, Jean-Christophe Navellou, Hervé Hyvernat, Ali Ait Hssain, Alexis Tabah, Jean-Louis Trouillet, Michel Wolff
OBJECTIVE: To describe the clinical spectrum of infective endocarditis in critically ill patients and assess the impact of neurologic complications on outcomes. DESIGN: Prospective multicenter observational study conducted from April 2007 to October 2008. SETTING: Thirty-three intensive care units in 23 university-affiliated and 10 general French hospitals. PATIENTS: Two hundred twenty-five patients with definite IE were studied...
June 2011: Critical Care Medicine
Julian Wei-Tze Tang, Paul A Tambyah, Florence Yuk Lin Lai, Hong Kai Lee, Chun Kiat Lee, Tze Ping Loh, Lily Chiu, Evelyn Siew-Chuan Koay
BACKGROUND: Singapore is a tropical country with a temperature range of 23 degrees C to 35 degrees C and relative humidity of 48% to 100% throughout the year. Influenza incidence peaks in June through July and November through January, though influenza cases can be detected throughout the year. METHODS: Between May 1 and July 28, 2009, a novel dual-gene diagnostic polymerase chain reaction assay targeting the hemagglutinin (HA) and nucleoprotein (NP) genes of the new influenza A(H1N1/2009) virus was specifically designed for enhanced influenza surveillance using nasopharyngeal swabs collected from symptomatic patients (including their close contacts) and returning travelers returning from influenza A(H1N1/2009)-affected areas, presenting to affiliated primary care clinics as well as the main hospital emergency department...
May 24, 2010: Archives of Internal Medicine
Florence Lebert
Patients with frontotemporal dementia (FTD) have major behavioral troubles and a loss of insight. These factors contribute to reduce self-awareness and recognition of identify of others and by others. Autobiographical amnesia, loss of insight and executive dysfunctions are the major reasons of vulnerable "self" in FTD. Mind representation deficits, decrease of perception of emotions and semantic amnesia contribute to reduced recognition of the relative's identity. Alterations of body expressions, social disinhibition, changes in social and religious values decrease the recognition of patient's identity by the relatives...
June 2009: Psychologie & Neuropsychiatrie du Vieillissement
Jacques Cassaing, Florence Isaac
The mating system of murids remains largely unknown, with controversial reports. Reevaluation of previous data reveals monogamous features in the Algerian mouse from the South of France, Mus spretus. To test this hypothesis, we performed dyadic encounters toward three kinds of opponents from the other sex (his/her own mate, a mouse from an unknown pair, and an isolated individual), and compared the results to those of a related acknowledgedly polygynous related species, the house mouse M. musculus domesticus...
November 2007: Comptes Rendus Biologies
Benoît Varenne, Poul Erik Petersen, Florence Fournet, Philippe Msellati, Jean Gary, Seydou Ouattara, Maud Harang, Gérard Salem
BACKGROUND: In sub-Saharan Africa, the availability and accessibility of oral health services are seriously constrained and the provision of essential oral care is limited. Reports from the region show a very low utilization of oral health care services, and visits to dental-care facilities are mostly undertaken for symptomatic reasons. The objectives of the present study were to describe the prevalence of oral symptoms among adults in Ouagadougou, capital city of Burkina Faso and the use of oral health services and self-medication in response to these symptoms and to measure the associations between predisposing, enabling and needs factors and decisions to seek oral health care...
2006: BMC Health Services Research
D Coskun, J Aytac, A Aydinli, A Bayer
Florence Nightingale Hospital is a 300-bed, university-affiliated, private medical centre with a large open heart surgery programme in Istanbul, Turkey. In this study, the mortality rates, lengths of stay (LOS) and extra costs of patients with deep sternal surgical site infections (DSSSIs) and superficial sternal surgical site infections (SSSSIs) following coronary artery bypass grafting (CABG) were determined from January 1999 to December 2002. Group I included 52 patients with DSSSIs, Group II included 36 patients with SSSSIs and Group III included 88 controls...
June 2005: Journal of Hospital Infection
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