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Stephane Legriel, Edouard Bresson, Nicolas Deye, David Grimaldi, Bertrand Sauneuf, Olivier Lesieur, Jean-Baptiste Lascarrou, Laurent Argaud, Jonathan Chelly, Pascal Beuret, David Schnell, Anne-Laure Chateauneuf, Mathilde Holleville, François Perier, Virginie Lemiale, Cedric Bruel, Pierrick Cronier, Nicolas Pichon, Nicolas Mongardon, Nicolas de-Prost, Florence Dumas, Alain Cariou
OBJECTIVES: Cardiac arrest is a catastrophic event that may arise during the management of convulsive status epilepticus. We aimed to report the clinical characteristics, outcomes, and early predictors of convulsive status epilepticus-related cardiac arrest. DESIGN: Retrospective multicenter study. SETTING: Seventeen university or university affiliated participating ICUs in France and Belgium. PATIENTS: Consecutive patients admitted to the participating ICUs for management of successfully resuscitated out-of-hospital cardiac arrest complicating the initial management of convulsive status epilepticus between 2000 and 2015...
May 8, 2018: Critical Care Medicine
Jean-Maxime Girard, Mathilde Simorre, Florence Leperlier, Arnaud Reignier, Tiphaine Lefebvre, Paul Barrière, Thomas Fréour
OBJECTIVE(S): Beta human chorionic gonadotrophin (β-hCG) is secreted by placenta and detectable in maternal serum a few days after embryo implantation. The evolution of β-hCG serum levels is commonly used to confirm early pregnancy and differentiate normal pregnancies from others, either in spontaneous pregnancies or after IVF. However, little is known on the eventual link between blastocyst quality in IVF, pregnancy outcome, and βhCG kinetics. The objective was to evaluate the association between early βhCG rise, blastocyst morphology and pregnancy evolution in a single-blastocyst transfer program STUDY DESIGN: This retrospective cohort study was conducted in a University-affiliated IVF center in 441 couples undergoing 455 single blastocyst transfer cycles leading to a positive pregnancy test 12 days afterwards...
April 30, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Pengran Wang, Shirine Benhenda, Haiyan Wu, Valérie Lallemand-Breitenbach, Tao Zhen, Florence Jollivet, Laurent Peres, Yuwen Li, Sai-Juan Chen, Zhu Chen, Hugues de Thé, Guoyu Meng
In the originally published version of this Article, the authors Sai-Juan Chen and Zhu Chen were incorrectly listed as being affiliated with 'University Paris Diderot, Sorbonne Paris Cité, INSERM U944, CNRS UMR7212, Equipe labellisée LNCC, Hôpital St. Louis 1, Paris 75475, France', and the affiliation 'Institute of Health Sciences, Shanghai Institutes for Biological Sciences and Graduate School, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China' was inadvertently omitted. These errors have now been corrected in both the PDF and HTML versions of the Article...
May 4, 2018: Nature Communications
Charlotte Duranton, Florence Gaunet
Behavioral synchronization is evolutionary adaptive, fostering social cohesion. In humans, affiliation between partners is associated with a high level of behavioral synchronization; people show increased affiliation towards people who synchronize with them. Surprisingly, until recently, little was known about these phenomena at an interspecific level, which is, however, essential to better understand the respective roles of evolution and ontogeny. After presenting why dog-human dyads are a relevant biological model to study this field of social cognition, we review the recent findings about dog-human behavioral synchronization...
April 30, 2018: Learning & Behavior
Charlotte Duranton, Thierry Bedossa, Florence Gaunet
Behavioural synchronization is widespread among living beings, including humans. Pairs of humans synchronize their behaviour in various situations, such as walking together. Affiliation between dyadic partners is known to promote behavioral synchronization. Surprisingly, however, interspecific synchronization has recived little scientific investigation. Dogs are sensitive to human cues, and share strong affiliative bonds with their owners. We thus investigated whether, when allowed to move freely in an enclosed unfamiliar space, dogs synchronize their behaviour with that of their owners'...
September 28, 2017: Scientific Reports
Jacinta Kelly, Roger Watson, James Watson, Malachi Needham, Laura O Driscoll
In the past professional identity in nursing was inculcated in students alongside institutional pride. A strong sense of professional identity is key to staff retention and recruitment and key to the delivery of quality nursing care. With the wholesale transfer of pre-registration nursing education to the third level sector, however, the reality is that students now divide their affiliations between university and healthcare institutions and professional identity development may be stymied. For this reason, there is need to explore alternative means of developing professional identity...
September 2017: Nurse Education in Practice
Laura Leite, Florence Jude-Lemeilleur, Natalie Raymond, Isabel Henriques, Frédéric Garabetian, Artur Alves
According to the hologenome theory, the microbiota contributes to the fitness of the holobiont having an important role in its adaptation, survival, development, health, and evolution. Environmental stress also affects the microbiota and its capability to assist the holobiont in coping with stress factors. Here, we analyzed the diversity of cultivable bacteria associated with Manila clam tissues (mantle, gills, hemolymph) in two non-contaminated sites (Portugal and France) and one metal-contaminated site (Portugal)...
September 2017: Environmental Science and Pollution Research International
Nadia Kazdar, Florence Brugnon, Cyril Bouche, Guilhem Jouve, Ségolène Veau, Hortense Drapier, Chloé Rousseau, Céline Pimentel, Patricia Viard, Marc-Antoine Belaud-Rotureau, Célia Ravel
A prospective study on randomized patients was conducted to determine how morphokinetic parameters are altered in embryos grown in sequential versus global culture media. Eleven morphokinetic parameters of 160 single embryos transferred were analyzed by time lapse imaging involving two University-affiliated in vitro fertilization (IVF) centers. We found that the fading of the two pronuclei occurred earlier in global (22.56±2.15 hpi) versus sequential media (23.63±2.71 hpi; p=0.0297). Likewise, the first cleavage started earlier at 24...
August 1, 2017: Annales de Biologie Clinique
Jamal Ghoumid, Florence Petit, Odile Boute-Benejean, Frédéric Frenois, Maryse Cartigny, Clémence Vanlerberghe, Thomas Smol, Roseline Caumes, Nicolas de Roux, Sylvie Manouvrier-Hanu
CHES (cerebellar hypoplasia with endosteal sclerosis) syndrome (OMIM#213002) associates hypomyelination, cerebellar atrophy, hypogonadism and hypodontia. So far, only five patients have been described. The condition is of neonatal onset. Patients have severe psychomotor delay and moderate to severe intellectual disability. Inheritance is assumed to be autosomal recessive due to recurrence in sibs, consanguinity of parents and absence of vertical transmission. CHES syndrome is reminiscent of 4H-leukodystrophy, a recessive-inherited affection due to variations in genes encoding subunits of the RNA polymerase III (POLR3A-POLR3B-POLR1C)...
August 2017: European Journal of Human Genetics: EJHG
Paul Krueger, David White, Christopher Meaney, Jeffrey Kwong, Viola Antao, Florence Kim
OBJECTIVE: To identify predictors of job satisfaction among academic family medicine faculty members. DESIGN: A comprehensive Web-based survey of all faculty members in an academic department of family medicine. Bivariate and multivariable analyses (logistic regression) were used to identify variables associated with job satisfaction. SETTING: The Department of Family and Community Medicine at the University of Toronto in Ontario and its 15 affiliated community teaching hospitals and community-based teaching practices...
March 2017: Canadian Family Physician Médecin de Famille Canadien
Godelieve Meunier, Loic Ysebaert, Phi Linh Nguyen-Thi, Stéphane Lepretre, Anne Quinquenel, Jehan Dupuis, Richard Lemal, Thérèse Aurran, Cécile Tomowiak, Florence Cymbalista, Marie Sarah Dilhuydy, Annie Brion, Pierre Morel, Bruno Cazin, Véronique Leblond, Guillaume Cartron, Daniel Ré, Marie Christine Béné, Anne Sophie Michallet, Pierre Feugier
The mean age at diagnosis of chronic lymphocytic leukemia (CLL) is 72 years, with 22.8% of patients being older than 80 years. However, the elderly are underrepresented in clinical studies of CLL. We performed a retrospective study of CLL patients aged 80 years or older at the initiation of first-line therapy in hospitals affiliated with the French intergroup on CLL (French Innovative Leukemia Organization) between 2003 and 2013. Here, we describe the clinical and biological characteristics, treatment, and outcomes for 201 patients...
December 2017: Hematological Oncology
Adriana G Ramirez, Margaret C Tracci, George J Stukenborg, Florence E Turrentine, Benjamin D Kozower, R Scott Jones
BACKGROUND: The Hospital Value-Based Purchasing Program measures value of care provided by participating Medicare hospitals and creates financial incentives for quality improvement and fosters increased transparency. Limited information is available comparing hospital performance across health care business models. STUDY DESIGN: The 2015 Hospital Value-Based Purchasing Program results were used to examine hospital performance by business model. General linear modeling assessed differences in mean total performance score, hospital case mix index, and differences after adjustment for differences in hospital case mix index...
October 2016: Journal of the American College of Surgeons
Vijay Ramaswamy, Thomas Hielscher, Stephen C Mack, Alvaro Lassaletta, Tong Lin, Kristian W Pajtler, David T W Jones, Betty Luu, Florence M G Cavalli, Kenneth Aldape, Marc Remke, Martin Mynarek, Stefan Rutkowski, Sridharan Gururangan, Roger E McLendon, Eric S Lipp, Christopher Dunham, Juliette Hukin, David D Eisenstat, Dorcas Fulton, Frank K H van Landeghem, Mariarita Santi, Marie-Lise C van Veelen, Erwin G Van Meir, Satoru Osuka, Xing Fan, Karin M Muraszko, Daniela P C Tirapelli, Sueli M Oba-Shinjo, Suely K N Marie, Carlos G Carlotti, Ji Yeoun Lee, Amulya A Nageswara Rao, Caterina Giannini, Claudia C Faria, Sofia Nunes, Jaume Mora, Ronald L Hamilton, Peter Hauser, Nada Jabado, Kevin Petrecca, Shin Jung, Luca Massimi, Massimo Zollo, Giuseppe Cinalli, László Bognár, Almos Klekner, Tibor Hortobágyi, Sarah Leary, Ralph P Ermoian, James M Olson, Jeffrey R Leonard, Corrine Gardner, Wieslawa A Grajkowska, Lola B Chambless, Jason Cain, Charles G Eberhart, Sama Ahsan, Maura Massimino, Felice Giangaspero, Francesca R Buttarelli, Roger J Packer, Lyndsey Emery, William H Yong, Horacio Soto, Linda M Liau, Richard Everson, Andrew Grossbach, Tarek Shalaby, Michael Grotzer, Matthias A Karajannis, David Zagzag, Helen Wheeler, Katja von Hoff, Marta M Alonso, Teresa Tuñon, Ulrich Schüller, Karel Zitterbart, Jaroslav Sterba, Jennifer A Chan, Miguel Guzman, Samer K Elbabaa, Howard Colman, Girish Dhall, Paul G Fisher, Maryam Fouladi, Amar Gajjar, Stewart Goldman, Eugene Hwang, Marcel Kool, Harshad Ladha, Elizabeth Vera-Bolanos, Khalida Wani, Frank Lieberman, Tom Mikkelsen, Antonio M Omuro, Ian F Pollack, Michael Prados, H Ian Robins, Riccardo Soffietti, Jing Wu, Phillipe Metellus, Uri Tabori, Ute Bartels, Eric Bouffet, Cynthia E Hawkins, James T Rutka, Peter Dirks, Stefan M Pfister, Thomas E Merchant, Mark R Gilbert, Terri S Armstrong, Andrey Korshunov, David W Ellison, Michael D Taylor
PURPOSE: Posterior fossa ependymoma comprises two distinct molecular variants termed EPN_PFA and EPN_PFB that have a distinct biology and natural history. The therapeutic value of cytoreductive surgery and radiation therapy for posterior fossa ependymoma after accounting for molecular subgroup is not known. METHODS: Four independent nonoverlapping retrospective cohorts of posterior fossa ependymomas (n = 820) were profiled using genome-wide methylation arrays. Risk stratification models were designed based on known clinical and newly described molecular biomarkers identified by multivariable Cox proportional hazards analyses...
July 20, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Deidre M Anglin, Florence Lui, Adriana Espinosa, Aleksandr Tikhonov, Lauren Ellman
AIM: Studies suggest strong ethnic identity generally protects against negative mental health outcomes associated with racial discrimination. In light of evidence suggesting racial discrimination may enhance psychosis risk in racial and ethnic minority (REM) populations, the present study explored the relationship between ethnic identity and attenuated positive psychotic symptoms (APPS) and whether ethnic identity moderates the association between racial discrimination and these symptoms...
January 28, 2016: Early Intervention in Psychiatry
Lionel Dany, Karine Baumstarck, Eric Dudoit, Florence Duffaud, Pascal Auquier, Sébastien Salas
BACKGROUND: The question whether euthanasia should be legalised has led to substantial public debate in France. The objective of this study in a sample of French physicians was to establish the potential determinants of a favourable opinion about euthanasia in general and when faced with a specific situation as embodied in the Humbert affair. METHODS: The study was a cross-sectional survey investigating two different samples of medical doctors: (1) those specialised in palliative care and affiliated to the French Society for Patient Accompaniment and Palliative Care; (2) medical interns (medical doctors in training course) in a French medical university (Marseille)...
2015: BMC Palliative Care
Xin Wang, Adrian M Dubuc, Vijay Ramaswamy, Stephen Mack, Deena M A Gendoo, Marc Remke, Xiaochong Wu, Livia Garzia, Betty Luu, Florence Cavalli, John Peacock, Borja López, Patryk Skowron, David Zagzag, David Lyden, Caitlin Hoffman, Yoon-Jae Cho, Charles Eberhart, Tobey MacDonald, Xiao-Nan Li, Timothy Van Meter, Paul A Northcott, Benjamin Haibe-Kains, Cynthia Hawkins, James T Rutka, Eric Bouffet, Stefan M Pfister, Andrey Korshunov, Michael D Taylor
Medulloblastoma comprises four distinct molecular variants with distinct genetics, transcriptomes, and outcomes. Subgroup affiliation has been previously shown to remain stable at the time of recurrence, which likely reflects their distinct cells of origin. However, a therapeutically relevant question that remains unanswered is subgroup stability in the metastatic compartment. We assembled a cohort of 12-paired primary-metastatic tumors collected in the MAGIC consortium, and established their molecular subgroup affiliation by performing integrative gene expression and DNA methylation analysis...
March 2015: Acta Neuropathologica
Cléa Bauvais, Séverine Zirah, Laurie Piette, Florence Chaspoul, Isabelle Domart-Coulon, Virginie Chapon, Philippe Gallice, Sylvie Rebuffat, Thierry Pérez, Marie-Lise Bourguet-Kondracki
The present study explored the bacteria of the sponge Spongia officinalis in a metal-polluted environment, using PCR-DGGE fingerprinting, culture-dependent approaches and in situ hybridization. The sponge samples collected over three consecutive years in the Western Mediterranean Sea contained high concentrations of zinc, nickel, lead and copper determined by ICP-MS. DGGE signatures indicated a sponge specific bacterial association and suggested spatial and temporal variations. The bacterial culturable fraction associated with S...
March 2015: Marine Environmental Research
Angelina Chemerys, Eric Pelletier, Corinne Cruaud, Florence Martin, Fabien Violet, Yves Jouanneau
Ring-hydroxylating dioxygenases (RHDs) play a crucial role in the biodegradation of a range of aromatic hydrocarbons found on polluted sites, including polycyclic aromatic hydrocarbons (PAHs). Current knowledge on RHDs comes essentially from studies on culturable bacterial strains, while compelling evidence indicates that pollutant removal is mostly achieved by uncultured species. In this study, a combination of DNA-SIP labeling and metagenomic sequence analysis was implemented to investigate the metabolic potential of main PAH degraders on a polluted site...
November 2014: Applied and Environmental Microbiology
Philippe Guerci, Florence Vial, Jérôme Feugeas, Marius Pop, Nour-Eddine Baka, Hervé Bouaziz, Marie-Reine Losser
OBJECTIVES: To determine the regional cerebral oxygen saturation of hemoglobin (rcSO2) in severe preeclamptic parturients exhibiting neurologic symptoms compared with healthy pregnant women (control) and to describe the effects of MgSO4 infusion on rcSO2 and cerebral and systemic hemodynamic variables. DESIGN: Prospective, observational study. SETTING: Obstetric critical care unit in a university-affiliated hospital. PATIENTS: Twenty severe preeclamptic parturients presenting with neurologic signs before any administration of MgSO4, and 20 control parturients...
November 2014: Critical Care Medicine
H Bjørn Nielsen, Mathieu Almeida, Agnieszka Sierakowska Juncker, Simon Rasmussen, Junhua Li, Shinichi Sunagawa, Damian R Plichta, Laurent Gautier, Anders G Pedersen, Emmanuelle Le Chatelier, Eric Pelletier, Ida Bonde, Trine Nielsen, Chaysavanh Manichanh, Manimozhiyan Arumugam, Jean-Michel Batto, Marcelo B Quintanilha Dos Santos, Nikolaj Blom, Natalia Borruel, Kristoffer S Burgdorf, Fouad Boumezbeur, Francesc Casellas, Joël Doré, Piotr Dworzynski, Francisco Guarner, Torben Hansen, Falk Hildebrand, Rolf S Kaas, Sean Kennedy, Karsten Kristiansen, Jens Roat Kultima, Pierre Léonard, Florence Levenez, Ole Lund, Bouziane Moumen, Denis Le Paslier, Nicolas Pons, Oluf Pedersen, Edi Prifti, Junjie Qin, Jeroen Raes, Søren Sørensen, Julien Tap, Sebastian Tims, David W Ussery, Takuji Yamada, Pierre Renault, Thomas Sicheritz-Ponten, Peer Bork, Jun Wang, Søren Brunak, S Dusko Ehrlich
Most current approaches for analyzing metagenomic data rely on comparisons to reference genomes, but the microbial diversity of many environments extends far beyond what is covered by reference databases. De novo segregation of complex metagenomic data into specific biological entities, such as particular bacterial strains or viruses, remains a largely unsolved problem. Here we present a method, based on binning co-abundant genes across a series of metagenomic samples, that enables comprehensive discovery of new microbial organisms, viruses and co-inherited genetic entities and aids assembly of microbial genomes without the need for reference sequences...
August 2014: Nature Biotechnology
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