Wen Hou, Lejun Huang, Hao Huang, Shenglan Liu, Wei Dai, Jianhong Tang, Xiangzhao Chen, Xiaolu Lu, Qisheng Zheng, Zhinuo Zhou, Ziyun Zhang, Jinxia Lan
Sinomenine, an isoquinoline alkaloid extracted from the roots and stems of Sinomenium acutum , has been extensively studied for its derivatives as bioactive agents. This review concentrates on the research advancements in the biological activities and action mechanisms of sinomenine-related compounds until November 2023. The findings indicate a broad spectrum of pharmacological effects, including antitumor, anti-inflammation, neuroprotection, and immunosuppressive properties. These compounds are notably effective against breast, lung, liver, and prostate cancers, exhibiting IC50 values of approximately 121...
January 22, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry