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https://www.readbyqxmd.com/read/27890885/medication-adherence-improvement-by-using-administration-timing-simplification-protocol-atsp-in-cardiovascular-disease-patients
#1
Sun Hoi Jung, Ok Sang Lee, Hyang Sook Kim, Chan Soon Park, Hyun Jung Lee, Kyeng Hee Kwon, Hae Young Lee
AIMS: In chronic diseases, keeping adherence to medication is very difficult. The objective of this study was to evaluate the impact of administration timing simplification protocol (ATSP) on medication adherence and clinical parameters of cardiovascular diseases. METHODS: 210 out-patients with cardiovascular disease, who were taking two or more pills of any type of medication per day for more than one year, were enrolled and randomized. The intervention group followed the simplified administration schedule of ATSP with two main strategies: 1) moving medication from "pc" (30 minute after meal) to "stat...
November 25, 2016: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/27881648/modeling-severe-fever-with-thrombocytopenia-syndrome-virus-infection-in-golden-syrian-hamsters-importance-of-stat2-in-preventing-disease-and-effective-treatment-with-favipiravir
#2
Brian B Gowen, Jonna B Westover, Jinxin Miao, Arnaud J Van Wettere, Johanna D Rigas, Brady T Hickerson, Kie-Hoon Jung, Rong Li, Bettina L Conrad, Skot Nielson, Yousuke Furuta, Zhongde Wang
: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease endemic in parts of Asia. The etiologic agent, SFTS virus (SFTSV; Bunyaviridae family, Phlebovirus genus) has caused significant morbidity and mortality in China, Korea, and Japan, with key features of disease being intense fever, thrombocytopenia, and leukopenia. Case fatality rates are estimated in the 30% range and no antivirals or vaccines are approved for use for treatment and prevention of SFTS...
November 23, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27766088/effectiveness-of-caregiver-training-in-mindfulness-based-positive-behavior-support-mbpbs-vs-training-as-usual-tau-a-randomized-controlled-trial
#3
Nirbhay N Singh, Giulio E Lancioni, Bryan T Karazsia, Jeffrey Chan, Alan S W Winton
Caregivers of individuals with intellectual and developmental disabilities (IDD) often end up having their medical and psychological well-being compromised due to the stressful nature of caregiving, especially when those in their care engage in aggressive behavior. In this study, we provided caregivers with mindfulness-based training to enable them to better manage their psychological well-being and, through this, to also enhance specific indices of quality of life of the individuals in their care. Thus, the aim of the present study was to evaluate in a randomized controlled trial (RCT) the comparative effectiveness of Mindfulness-Based Positive Behavior Support (MBPBS) and Training-as-Usual (TAU) for caregivers in a congregate care facility for individuals with severe and profound IDD...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27742706/hsp90-inhibition-overcomes-ibrutinib-resistance-in-mantle-cell-lymphoma
#4
Caron Jacobson, Nadja Kopp, Jacob V Layer, Robert A Redd, Sebastian Tschuri, Sarah Haebe, Diederik van Bodegom, Liat Bird, Amanda L Christie, Alexandra Christodoulou, Amy Saur, Trevor Tivey, Stefanie Zapf, Deepak Bararia, Ursula Zimber-Strobl, Scott J Rodig, Oliver Weigert, David M Weinstock
The Bruton tyrosine kinase (BTK) inhibitor ibrutinib induces responses in 70% of patients with relapsed and refractory mantle cell lymphoma (MCL). Intrinsic resistance can occur through activation of the nonclassical NF-κB pathway and acquired resistance may involve the BTK C481S mutation. Outcomes after ibrutinib failure are dismal, indicating an unmet medical need. We reasoned that newer heat shock protein 90 (HSP90) inhibitors could overcome ibrutinib resistance by targeting multiple oncogenic pathways in MCL...
November 24, 2016: Blood
https://www.readbyqxmd.com/read/27734126/independent-risk-factors-for-surgical-site-infection-after-cesarean-delivery-in-a-rural-tertiary-care-medical-center
#5
Manuel C Vallejo, Ahmed F Attaallah, Robert E Shapiro, Osama M Elzamzamy, Michael G Mueller, Warren S Eller
BACKGROUND: We aimed to determine the incidence of surgical site infection (SSI) after cesarean delivery (CD) and identify the risk factors in a rural population. METHODS: We identified 218 SSI patients by International Classification of Disease codes and matched them with 3131 parturients (control) from the electronic record database in a time-matched retrospective quality assurance analysis. RESULTS AND DISCUSSION: The incidence of SSI after CD was 7...
October 12, 2016: Journal of Anesthesia
https://www.readbyqxmd.com/read/27709092/antegrade-cerebral-perfusion-at-25-%C3%A2-c-for-arch-reconstruction-in-newborns-and-children-preserves-perioperative-cerebral-oxygenation-and-serum-creatinine
#6
Bhawna Gupta, Ali Dodge-Khatami, Juan Tucker, Mary B Taylor, Douglas Maposa, Miguel Urencio, Jorge D Salazar
BACKGROUND: Antegrade cerebral perfusion (ACP) typically is used with deep hypothermia for cerebral protection during aortic arch reconstructions. The impact of ACP on cerebral oxygenation and serum creatinine at a more tepid 25 °C was studied in newborns and children. METHODS: Between 2010 and 2014, 61 newborns and children (<5 years old) underwent aortic arch reconstruction using moderate hypothermia (25.0±0.9 °C) with ACP and a pH-stat blood gas management strategy...
July 2016: Translational pediatrics
https://www.readbyqxmd.com/read/27671823/natural-withanolides-in-the-treatment-of-chronic-diseases
#7
Peter T White, Chitra Subramanian, Hashim F Motiwala, Mark S Cohen
Withanolides, and in particular extracts from Withania somnifera, have been used for over 3,000 years in traditional Ayurvedic and Unani Indian medical systems as well as within several other Asian countries. Traditionally, the extracts were ascribed a wide range of pharmacologic properties with corresponding medical uses, including adaptogenic, diuretic, anti-inflammatory, sedative/anxiolytic, cytotoxic, antitussive, and immunomodulatory. Since the discovery of the archetype withaferin A in 1965, approximately 900 of these naturally occurring, polyoxygenated steroidal lactones with 28-carbon ergostane skeletons have been discovered across 24 diverse structural types...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27611442/utility-of-electroencephalography-experience-from-a-u-s-tertiary-care-medical-center
#8
Kapil Gururangan, Babak Razavi, Josef Parvizi
OBJECTIVE: To investigate the utility of electroencephalography (EEG) for evaluation of patients with altered mental status (AMS). METHODS: We retrospectively reviewed 200 continuous EEGs (cEEGs) obtained in ICU and non-ICU wards and 100 spot EEGs (sEEGs) obtained from the emergency department (ED) of a large tertiary medical center. Main outcomes were access time (from study request to hookup), and diagnostic yield (percentage of studies revealing significant abnormality)...
October 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/27581546/effect-of-memory-cd4-t-cells-signal-transducer-and-activator-of-transcription-stats-functional-shift-on-cytokine-releasing-properties-in-asthma
#9
Zhihong Chen, Jue Pan, Yi Jia, Dandan Li, Zhihui Min, Xiaoqiong Su, Honglei Yuan, Geng Shen, Shengxuan Cao, Lei Zhu, Xiangdong Wang
BACKGROUND: Recent data have demonstrated that long-lived memory T cells are present in the human lung and can play significant roles in the pathogenesis of specific allergic and autoimmune diseases. However, most evidence has been obtained from mouse studies, and the potential roles of memory T cells in human allergic diseases, such as asthma, remain largely unknown. METHODS: Thirty-three asthmatics, 26 chronic obstructive pulmonary disease (COPD) patients, and 22 healthy volunteers were enrolled in this study...
August 31, 2016: Cell Biology and Toxicology
https://www.readbyqxmd.com/read/27568833/mechanistic-insight-of-diabetic-nephropathy-and-its-pharmacotherapeutic-targets-an-update
#10
Niloy Bhattacharjee, Sujata Barma, Nandita Konwar, Saikat Dewanjee, Prasenjit Manna
Diabetic nephropathy (DN), a chronic complication of diabetes, is charecterized by glomerular hypertrophy, proteinuria, decreased glomerular filtration, and renal fibrosis resulting in the loss of renal function. Although the exact cause of DN remains unclear, several mechanisms have been postulated, such as hyperglycemia-induced renal hyper filtration and renal injury, AGEs-induced increased oxidative stress, activated PKC-induced increased production of cytokines, chemokines, and different inflammatory and apoptotic signals...
August 25, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27505936/beyond-blood-sugar
#11
Matt Zavadsky, Desiree Partain
Because POC testing has been shown to alter prehospital care in up to 30% of its uses, it may be logical for prehospital systems to consider implementing a POC testing system. Information gleaned from the i-STAT data can be used to treat electrolyte imbalances, adjust medications and ventilator settings, and even change IV fluid use. MIH providers can also use the data from POC testing to provide important feedback to physicians about enrolled patients. All of these uses support critical clinical decision making by field EMS providers, and will perhaps even help promote the value proposition we're all striving for in our EMS delivery models...
June 2016: JEMS: a Journal of Emergency Medical Services
https://www.readbyqxmd.com/read/27478535/bioactivity-of-polyphenols-preventive-and-adjuvant-strategies-toward-reducing-inflammatory-bowel-diseases-promises-perspectives-and-pitfalls
#12
REVIEW
Anouk Kaulmann, Torsten Bohn
Inflammatory bowel diseases (IBDs) are characterized by autoimmune and inflammation-related complications of the large intestine (ulcerative colitis) and additional parts of the digestive tract (Crohn's disease). Complications include pain, diarrhoea, chronic inflammation, and cancer. IBD prevalence has increased during the past decades, especially in Westernized countries, being as high as 1%. As prognosis is poor and medication often ineffective or causing side effects, additional preventive/adjuvant strategies are sought...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27398263/matrix-metalloproteinase-9-production-by-immortalized-human-chondrocyte-lines
#13
Charles J Malemud, Evan C Meszaros, Meredith A Wylie, Wissam Dahoud, Yelenna Skomorovska-Prokvolit, Sam Mesiano
We reported at the Keynote Forum of Immunology Summit-2015 that recombinant human (rh) TNF-α or rhIL-6 stimulated production of matrix metalloproteinase-9 (MMP-9) in the T/C28a2 and C-28/I2 human immortalized chondrocyte cell lines. Furthermore, we reported that tocilizumab (TCZ), a fully humanized monoclonal antibody which neutralizes IL-6-mediated signaling, inhibited the rhIL-6-mediated increase in the production of MMP-9. IL-6 is also a known activator of the JAK/STAT signaling pathway. In that regard, we evaluated the effect of rhIL-6 on total and phosphorylated Signal Transducer and Activator of Transcription by these chondrocyte lines which showed that whereas STAT3 was constitutively phosphorylated in T/C28a2 chondrocytes, rhIL-6 activated STAT3 in C-28/I2 chondrocytes...
June 2016: Journal of Clinical & Cellular Immunology
https://www.readbyqxmd.com/read/27382418/evaluation-of-stat-medication-ordering-process-in-a-community-hospital
#14
Hani Abdelaziz, Sandra Richardson, Kim Walsh, Jessica Nodzon, Barbara Schwartz
BACKGROUND: In most health care facilities, problems related to delays in STAT medication order processing time are of common concern. OBJECTIVE: The purpose of this study was to evaluate processing time for STAT orders at Kimball Medical Center. METHODS: All STAT orders were reviewed to determine processing time; order processing time was also stratified by physician order entry (physician entered (PE) orders vs. non-physician entered (NPE) orders)...
April 2016: Pharmacy Practice
https://www.readbyqxmd.com/read/27376040/elisa-reader-does-not-interfere-by-mobile-phone-radiofrequency-radiation
#15
Seyyed Mohammad Javad Mortazavi, Hamid Reza Baradaran-Ghahfarokhi, Mohammad Reza Abdi, Milad Baradaran-Ghahfarokhi, Nayyer Sadat Mostafavi, Golshan Mahmoudi, Nafiseh Berenjkoub, Zahra Akmali, Fahimeh Hossein-Beigi, Vajiheh Arsang
BACKGROUND: The increasing number of mobile phones can physically cause electromagnetic interference (EMI) in medical environments; can also cause errors in immunoassays in laboratories. The ELISA readers are widely used as a useful diagnostic tool for Enzymun colorimetric assay in medicine. The aim of this study was to investigate whether the ELISA reader could be interfered by the exposure to the 900 MHz cell phones in the laboratory. MATERIALS AND METHODS: Human serum samples were collected from 14 healthy donors (9 women and 5 men) and each sample was divided into four aliquots and was placed into four batches for the in-vitro quantitative determination of human chorionic gonadotropin (hCG)...
2016: Advanced Biomedical Research
https://www.readbyqxmd.com/read/27339942/immune-signaling-based-cascade-propagation-approach-re-stratifies-hnscc-patients
#16
Keqin Liu, Jacqueline Chyr, Weiling Zhao, Xiaobo Zhou
The availability of high-throughput genomic assays and rich electronic medical records allows us to identify cancer subtypes with greater accuracy and resolution. The integration of multiplatform, heterogenous, and high dimensional data remains an enormous challenge in using big data in bioinformatics research. Previous methods have been developed for patient stratification, however, these approaches did not incorporate prior knowledge and offer limited biology insight. New computational methods are needed to better utilize multiple types of information to identify clinically meaningful subtypes...
December 1, 2016: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/27306946/absence-of-neonatal-intensive-care-units-in-secondary-medical-care-zones-is-an-independent-risk-factor-of-high-perinatal-mortality-in-japan
#17
Yoko Matsumoto, Akihito Nakai, Yasuhiro Nishijima, Eisaku Kishita, Haruhiko Hakuno, Masami Sakoi, Satoshi Kusuda, Nobuya Unno, Masanori Tamura, Tomoyuki Fujii
AIM: National medical projects are carried out according to medical care plans directed by the Medical Care Act of Japan. In order to improve Japanese perinatal medical care, it is necessary to determine the factors that might influence perinatal outcome. METHODS: Statistical data of births and perinatal deaths were obtained for all municipalities in Japan from 2008 to 2012 from the Portal Site of Official Statistics of Japan (e-Stat). The perinatal mortality of all 349 Japanese secondary medical care zones was calculated...
June 16, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27251106/reduction-of-laboratory-utilization-in-the-intensive-care-unit
#18
Samih Raad, Rachel Elliott, Evan Dickerson, Babar Khan, Khalil Diab
OBJECTIVE: In our academic intensive care unit (ICU), there is excess ordering of routine laboratory tests. This is partially due to a lack of transparency of laboratory-processing costs and to the admission order plans that favor daily laboratory test orders. We hypothesized that a program that involves physician and staff education and alters the current ICU order sets will lead to a sustained decrease in routine laboratory test ordering. DESIGN: Prospective cohort study...
June 1, 2016: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/27248514/smart-statistical-metabolomics-analysis-an-r-tool
#19
Yu-Jen Liang, Yu-Ting Lin, Chia-Wei Chen, Chien-Wei Lin, Kun-Mao Chao, Wen-Harn Pan, Hsin-Chou Yang
Metabolomics data provide unprecedented opportunities to decipher metabolic mechanisms by analyzing hundreds to thousands of metabolites. Data quality concerns and complex batch effects in metabolomics must be appropriately addressed through statistical analysis. This study developed an integrated analysis tool for metabolomics studies to streamline the complete analysis flow from initial data preprocessing to downstream association analysis. We developed Statistical Metabolomics Analysis-An R Tool (SMART), which can analyze input files with different formats, visually represent various types of data features, implement peak alignment and annotation, conduct quality control for samples and peaks, explore batch effects, and perform association analysis...
June 21, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27153703/phasing-for-medical-sequencing-using-rare-variants-and-large-haplotype-reference-panels
#20
Kevin Sharp, Warren Kretzschmar, Olivier Delaneau, Jonathan Marchini
MOTIVATION: There is growing recognition that estimating haplotypes from high coverage sequencing of single samples in clinical settings is an important problem. At the same time very large datasets consisting of tens and hundreds of thousands of high-coverage sequenced samples will soon be available. We describe a method that takes advantage of these huge human genetic variation resources and rare variant sharing patterns to estimate haplotypes on single sequenced samples. Sharing rare variants between two individuals is more likely to arise from a recent common ancestor and, hence, also more likely to indicate similar shared haplotypes over a substantial flanking region of sequence...
July 1, 2016: Bioinformatics
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