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S100B protein

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https://www.readbyqxmd.com/read/28099628/elevated-plasma-concentrations-of-s100-calcium-binding-protein-b-and-tumor-necrosis-factor-alpha-in-children-with-autism-spectrum-disorders
#1
Selin Aktan Guloksuz, Osman Abali, Esin Aktas Cetin, Sema Bilgic Gazioglu, Gunnur Deniz, Abdurrahman Yildirim, Ivana Kawikova, Sinan Guloksuz, James F Leckman
Objective: To investigate plasma concentrations of S100B (a calcium-binding protein derived primarily from the glia) and inflammatory cytokines in children with autism and the relationship between S100B and cytokine concentrations. Methods: Plasma levels of S100B, tumor necrosis factor alpha (TNF-α), interferon gamma, interleukin (IL)-1β, IL-4, IL-6, IL-10, and IL-17A were measured in 40 unmedicated children with autism and 35 normally developing healthy children...
January 12, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28088747/decreased-s100b-serum-levels-after-treatment-in-bipolar-patients-in-a-manic-phase
#2
Meng-Chang Tsai, Tiao-Lai Huang
BACKGROUND: Previous studies have suggested that patients with bipolar disorder might have brain damage. The aim of this study was to investigate the serum levels of brain injury biomarkers and S100A10 in bipolar patients in a manic phase, and evaluate the changes in S100B, neuron specific enolase (NSE), heat shock protein 70 (HSP70) and S100A10 after treatment. METHOD: We consecutively enrolled 17 bipolar inpatients in a manic phase and 30 healthy subjects. Serum brain injury biomarkers and S100A10 were measured with assay kits...
January 3, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28063977/enteric-glial-reactivity-to-systemic-lps-administration-changes-in-gfap-and-s100b-protein
#3
Raphaela da Cunha Franceschi, Patrícia Nardin, Clivia Valle Machado, Lucas Silva Tortorelli, Malcon Andrei Martinez-Pereira, Carolline Zanotto, Carlos Alberto Gonçalves, Denise Maria Zancan
Lipopolysaccharide (LPS) is used to induce inflammation and promotes nervous system activation. Different regions of the brain present heterogeneous glial responses; thus, in order to verify whether systemic LPS-induced inflammation affects the enteric glia differently across the intestinal segments, we evaluated the expressions of two glial activity markers, GFAP and S100B protein, in different intestine segments, at 1h, 24h and 7days after acute systemic LPS administration (0.25 or 2.5mg kg-1) in rats. Histological inflammatory analysis indicated that the cecum was most affected when compared to the duodenum and proximal colon at the highest doses of LPS...
January 4, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/28033253/postoperative-cognitive-changes-after-total-knee-arthroplasty-under-regional-anesthesia
#4
Young-Tae Jeon, Byung-Gun Kim, Young Ho Park, Hye-Min Sohn, Jungeun Kim, Seung Chan Kim, Seong Soo An, SangYun Kim
BACKGROUND: The type of postoperative cognitive decline after surgery under spinal anesthesia is unknown. We investigated the type of postoperative cognitive decline after total knee arthroplasty (TKA). Neuropsychological testing was conducted and the changes in cerebrospinal fluid (CSF) biomarkers after surgery were evaluated. METHODS: Fifteen patients who required bilateral TKA at a 1-week interval under spinal anesthesia were included. Neuropsychological tests were performed twice, once the day before the first operation and just before the second operation (usually 1 week after the first test) to determine cognitive decline...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28031000/modeling-the-kinetics-of-serum-glial-fibrillary-acidic-protein-ubiquitin-carboxyl-terminal-hydrolase-l1-and-s100b-concentrations-in-patients-with-traumatic-brain-injury
#5
Robert D Welch, Morgan Ellis, Lawrence M Lewis, Syed Imran Ayaz, Valerie H Mika, Scott R Millis, Linda Papa
Glial fibrillary acidic protein (GFAP), Ubiquitin Carboxyl-Terminal Hydrolase-L1 (UCH-L1), and S100B have been shown to be predictive of patients with brain injury. Kinetics of these biomarkers in injured humans have not been extensively examined. This prospective multi-center study included patients with mild to moderate traumatic brain injury. Blood samples obtained at enrollment and every 6 hours up to 24 hours post-injury were assayed for GFAP, UCH-L1, and S100B. Random effects models examined changes in the biomarkers' level over time...
December 28, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27995575/cerebrospinal-fluid-biomarkers-and-hiv-associated-neurocognitive-disorders-in-hiv-infected-individuals-in-rakai-uganda
#6
Mahsa Abassi, Bozena M Morawski, Gertrude Nakigozi, Noeline Nakasujja, Xiangrong Kong, David B Meya, Kevin Robertson, Ronald Gray, Maria J Wawer, Ned Sacktor, David R Boulware
In the USA, increased cerebrospinal fluid (CSF) inflammatory cytokines have been observed in antiretroviral therapy (ART)-naive, HIV-seropositive individuals with HIV-associated neurocognitive disorder (HAND). We characterized the relationship between HAND and CSF biomarker expression in ART-naive, HIV-seropositive individuals in Rakai, Uganda. We analyzed CSF of 78 HIV-seropositive, ART-naive Ugandan adults for 17 cytokines and 20 neurodegenerative biomarkers via Luminex multiplex assay. These adults underwent neurocognitive assessment to determine their degree of HAND...
December 19, 2016: Journal of Neurovirology
https://www.readbyqxmd.com/read/27995066/functional-resting-state-fmri-connectivity-correlates-with-serum-levels-of-the-s100b-protein-in-the-acute-phase-of-traumatic-brain-injury
#7
William Hedley Thompson, Eric Peter Thelin, Anders Lilja, Bo-Michael Bellander, Peter Fransson
The S100B protein is an intra-cellular calcium-binding protein that mainly resides in astrocytes in the central nervous system. The serum level of S100B is used as biomarker for the severity of brain damage in traumatic brain injury (TBI) patients. In this study we investigated the relationship between intrinsic resting-state brain connectivity, measured 1-22 days (mean 8 days) after trauma, and serum levels of S100B in a patient cohort with mild-to-severe TBI in need of neuro-intensive care in the acute phase...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27994924/correlation-between-amitriptyline-induced-cardiotoxic-effects-and-cardiac-s100b-protein-in-isolated-rat-hearts
#8
Nil Hocaoğlu, Nergis Murat, Serap Cilaker Mıcılı, Burç Aydın, Bekir Uğur Ergür, Şule Kalkan
BACKGROUND: Amitriptyline is an important cause of mortality due to its cardiovascular toxicity. AIMS: To investigate the changes in levels of cardiac S100b protein on amitriptyline-induced cardiotoxicity and also to examine the correlation between amitriptyline-induced cardiotoxic effects and cardiac S100b protein in an isolated rat heart model. STUDY DESIGN: Animal experimentation, isolated heart model. METHODS: After a stabilization period, isolated hearts were randomized to two groups (n=5 and n=7)...
November 2016: Balkan Medical Journal
https://www.readbyqxmd.com/read/27989465/neuroprotective-effect-of-sevoflurane-in-general-anaesthesia
#9
Victoria Ramos Ramos, Pablo Mesa Suárez, José Diego Santotoribio, María Ángela González García, Antonio Muñoz Hoyos
INTRODUCTION AND OBJECTIVE: The aim of this study was to evaluate the brain damage caused by inhaled sevoflurane, by determining the concentration of serum S100B protein before and after the exposure to this drug as the only anaesthetic agent. PATIENTS AND METHOD: Paediatric patients undergoing general anaesthesia for the conduct of a nuclear magnetic resonance were included in the study. A venous blood sample was taken from each patient before (basal sample) and after (post-exposure sample) administering the general anaesthesia...
December 15, 2016: Medicina Clínica
https://www.readbyqxmd.com/read/27957604/a-review-of-the-clinical-utility-of-serum-s100b-protein-levels-in-the-assessment-of-traumatic-brain-injury
#10
REVIEW
Eric Peter Thelin, David W Nelson, Bo-Michael Bellander
BACKGROUND: In order to improve injury assessment of brain injuries, protein markers of pathophysiological processes and tissue fate have been introduced in the clinic. The most studied protein "biomarker" of cerebral damage in traumatic brain injury (TBI) is the protein S100B. The aim of this narrative review is to thoroughly analyze the properties and capabilities of this biomarker with focus on clinical utility in the assessment of patients suffering from TBI. RESULTS: S100B has successfully been implemented in the clinic regionally (1) to screen mild TBI patients evaluating the need to perform a head computerized tomography, (2) to predict outcome in moderate-to-severe TBI patients, (3) to detect secondary injury development in brain-injured patients and (4) to evaluate treatment efficacy...
February 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/27956799/transient-receptor-potential-vanilloid-1-immunoreactive-signals-in-murine-enteric-glial-cells
#11
Masahiro Yamamoto, Mitsue Nishiyama, Seiichi Iizuka, Shigeaki Suzuki, Norihiro Suzuki, Sadakazu Aiso, Jin Nakahara
AIM: To investigate the possible involvement of transient receptor potential vanilloid 1 (TRPV1) in maturation of enteric glial cells (EGCs). METHODS: Immunohistochemical and immunocytochemical techniques were used to analyze EGC markers in myenteric plexus (MP) as well as cultured MP cells and EGCs using TRPV1 knockout (KO) mice. RESULTS: We detected TRPV1-immunoreactive signals in EGC in the MP of wild-type (WT) but not KO mice. Expression of glial fibrillary acidic protein (GFAP) immunoreactive signals was lower at postnatal day (PD) 6 in KO mice, though the difference was not clear at PD 13 and PD 21...
November 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27931233/venlafaxine-ameliorates-the-depression-like-behaviors-and-hippocampal-s100b-expression-in-a-rat-depression-model
#12
Chang-Hong Wang, Jing-Yang Gu, Xiao-Li Zhang, Jiao Dong, Jun Yang, Ying-Li Zhang, Qiu-Fen Ning, Xiao-Wen Shan, Yan Li
BACKGROUND: Accumulating evidence has indicated that S100B may be involved in the pathophysiology of depression. No published study has examined the effect of the antidepressant drug venlafaxine on S100B in animal models of depression. This study investigated S100B expression in the hippocampus and assessed the effect of venlafaxine on S100B mRNA level and protein expression in rats exposed to chronic unpredictable mild stress (CUMS). METHODS: Forty Sprague-Dawley rats were randomly divided into four groups as control, 0, 5 and 10 mg venlafaxine groups...
December 8, 2016: Behavioral and Brain Functions: BBF
https://www.readbyqxmd.com/read/27929120/neurofilaments-in-blood-and-csf-for-diagnosis-and-prediction-of-onset-in-creutzfeldt-jakob-disease
#13
Petra Steinacker, Kaj Blennow, Steffen Halbgebauer, Song Shi, Viktoria Ruf, Patrick Oeckl, Armin Giese, Jens Kuhle, Dana Slivarichova, Henrik Zetterberg, Markus Otto
While cerebrospinal fluid (CSF) biomarkers for Creutzfeldt-Jakob disease (CJD) are established and partly included in the diagnostic criteria, no blood biomarkers are available. Here, we assessed the utility of serum neurofilament light chain (NF-L) and tau protein in comparison to CSF markers (NF-L and phosphorylated NF heavy chain (pNF-H), tau, S100B, 14-3-3) and prion conversion assay (real-time quaking induced conversion (RT-QuIC)) for sporadic and genetic CJD. Importantly, a Gerstmann-Sträussler-Scheinker mutation carrier in the asymptomatic phase and at disease onset was included as well...
December 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27925190/s100a1-and-s100b-calcium-sensors-at-the-cross-roads-of-multiple-chondrogenic-pathways
#14
REVIEW
José Diaz-Romero, Dobrila Nesic
The S100 protein family comprises more than 20 members of small calcium binding proteins operating as Ca2 + -activated switches that interact and modulate the activity of a large number of targets. S100A1 and S100B, two members of this family, have been recently associated with the differentiation status of human articular chondrocytes. Both proteins are homogeneously expressed in all cartilage zones, their expression decreases during chondrocyte dedifferentiation, and can be induced under conditions promoting redifferentiation...
December 7, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27903281/improving-the-clinical-management-of-traumatic-brain-injury-through-the-pharmacokinetic-modeling-of-peripheral-blood-biomarkers
#15
Aaron Dadas, Jolewis Washington, Nicola Marchi, Damir Janigro
BACKGROUND: Blood biomarkers of neurovascular damage are used clinically to diagnose the presence severity or absence of neurological diseases, but data interpretation is confounded by a limited understanding of their dependence on variables other than the disease condition itself. These include half-life in blood, molecular weight, and marker-specific biophysical properties, as well as the effects of glomerular filtration, age, gender, and ethnicity. To study these factors, and to provide a method for markers' analyses, we developed a kinetic model that allows the integrated interpretation of these properties...
November 30, 2016: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/27882497/soluble-tlr2-and-4-concentrations-in-cerebrospinal-fluid-in-hiv-siv-related-neuropathological-conditions
#16
Khutso M Mothapo, J Ten Oever, P Koopmans, F F Stelma, S Burm, J Bajramovic, M M Verbeek, M G Olde Rikkert, M G Netea, G Koopman, A J van der Ven
HIV in the central nervous system (CNS) mainly infects microglial cells which are known to express toll-like receptors (TLRs). This paper aimed to study the role of soluble TLR2 (sTLR2), sTLR4, and other inflammatory markers in cerebrospinal fluid (CSF) in HIV/Simian immunodeficiency virus (SIV)-related neurological sequelae. We determined sTLR2 and sTLR4 levels in CSF and serum/plasma of SIV-infected rhesus macaques with and without neurological sequelae, as well as in HIV-infected patients with and without cognitive impairments and Alzheimer's disease (AD) patients and matched controls...
November 23, 2016: Journal of Neurovirology
https://www.readbyqxmd.com/read/27863321/cognitive-dysfunction-correlates-with-elevated-serum-s100b-concentration-in-drug-free-acutely-relapsed-patients-with-schizophrenia
#17
Song Chen, Li Tian, Nan Chen, Meihong Xiu, Zhiren Wang, Guigang Yang, Chuanyue Wang, Fude Yang, Yunlong Tan
S100B, a biomarker of glial dysfunction and blood-brain barrier (BBB) disruption, has been proposed to be involved in the pathophysiology of schizophrenia. In the present study, we aimed at exploring the association of serum S100B levels with cognitive deficits using MATRICS Consensus Cognitive Battery (MCCB) in schizophrenia, by excluding the impact of antipsychotics. Sixty-two unmedicated patients with schizophrenia during their acute phases were divided into a drug-naïve group (n=34) and a drug-free group (n=28)...
January 2017: Psychiatry Research
https://www.readbyqxmd.com/read/27861869/s100b%C3%A2-%C3%A2-a1-celisa-a-novel-potency-assay-and-screening-tool-for-redifferentiation-stimuli-of-human-articular-chondrocytes
#18
Jose Diaz-Romero, Sibylle Kürsener, Sandro Kohl, Dobrila Nesic
During monolayer expansion, a necessary step in autologous chondrocyte implantation, human articular chondrocytes (HAC) dedifferentiate and lose their capacity to produce stable hyaline cartilage. Determining HAC potency and learning how to trigger their redifferentiation would improve cell-based cartilage regeneration therapies. We previously identified S100B and S100A1 proteins as markers of HAC redifferentiation potential. Here, we aimed to: (i) demonstrate a correlation between S100B + A1-positive HAC in monolayer culture and their neochondrogenesis capacity in pellet culture; (ii) develop an S100B + A1 cell-based ELISA, and (iii) prove that S100B + A1 induction in HAC increases their chondrogenic capacity...
November 11, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27853253/generation-of-metastatic-melanoma-specific-antibodies-by-affinity-purification
#19
Birgit Schütz, Anita Koppensteiner, David Schörghofer, Katharina Kinslechner, Gerald Timelthaler, Robert Eferl, Markus Hengstschläger, Albert Missbichler, Harald Hundsberger, Mario Mikula
Melanoma is the most aggressive type of skin cancer and one of the most frequent tumours in young adults. Identification of primary tumours prone to develop metastasis is of paramount importance for further patient stratification. However, till today, no markers exist that are routinely used to predict melanoma progression. To ameliorate this problem, we generated antiserum directed against metastatic melanoma tissue lysate and applied a novel approach to purify the obtained serum via consecutive affinity chromatography steps...
November 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27847933/the-role-of-s100b-protein-as-a-potential-marker-in-affective-disorders
#20
REVIEW
Aleksandra Rajewska-Rager, Magdalena Pawlaczyk
INTRODUCTION: Both recurrent depressive disorders and affective bipolar disorders are characterized by the changes in glial tissue. S100B protein is a calcium-binding molecule, mainly secreted by glial cells, which, depending on its concentration, has a trophic or toxic effect on neuronal cells. In the recent years, due to the postulated glial hypothesis of affective disorders and the ideas concerning brain neuroplasticity, there has been a growing interest in S100B protein and its role in affective disorders...
2016: Psychiatria Polska
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