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https://www.readbyqxmd.com/read/29050407/layer-chicken-embryo-survival-to-hatch-when-administered-an-in-ovo-vaccination-of-strain-f-mycoplasma-gallisepticum-and-locations-of-bacteria-prevalence-in-the-newly-hatched-chick
#1
K E C Elliott, S L Branton, J D Evans, P D Gerard, E D Peebles
Mycoplasma gallisepticum (MG) is a bacterial pathogen that causes production losses in layer chickens. To combat MG, multiage layer facilities vaccinate pullets by either spray or eye-drop vaccination. The objective in this study was to evaluate the use of in ovo vaccination as a potential alternative for MG vaccination. Layer embryos at 18 d of incubation were either not-injected (control), or were hand-injected with either commercial Marek's disease vaccine diluent alone or with a high, medium, low, or very low dosage of a live attenuated strain F (FMG) vaccine suspended in the commercial diluent...
September 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/29049981/angiotensin-receptor-blockade-improves-cardiac-mitochondrial-activity-in-response-to-an-acute-glucose-load-in-obese-insulin-resistant-rats
#2
Max Thorwald, Ruben Rodriguez, Andrew Lee, Bridget Martinez, Janos Peti-Peterdi, Daisuke Nakano, Akira Nishiyama, Rudy M Ortiz
Hyperglycemia increases the risk of oxidant overproduction in the heart through activation of a multitude of pathways. Oxidation of mitochondrial enzymes may impair their function resulting in accumulation of intermediates and reverse electron transfer, contributing to mitochondrial dysfunction. Furthermore, the renin-angiotensin system (RAS) becomes inappropriately activated during metabolic syndrome, increasing oxidant production. To combat excess oxidant production, the transcription factor, nuclear factor erythriod-2- related factor 2 (Nrf2), induces expression of many antioxidant genes...
October 7, 2017: Redox Biology
https://www.readbyqxmd.com/read/29049977/syk-gtp-rac-1-mediated-immune-stimulatory-effect-of-cuscuta-epithymum-ipomoea-batata-and-euphorbia-hirta-plant-extracts
#3
Vanitha Sagar Sudam, Ajay Godwin Potnuri, N J Prameela Subhashini
Polymorphonuclear neutrophils (PMNn) are the pivotal mediators of phagocytosis. In addition to neutropenia, impaired neutrophilic function is associated with pathological conditions and immuno-deficiencies. Henceforth, Immuno-stimulatory strategies targeting neutrophilic function are indeed powerful tools in combating obstinate infections. In appreciation towards the usefulness of herbal medicines in therapeutic scenario, the present study was carried out to analyse the immuno-stimulatory effect of Cuscuta epithymum, Ipomoea batata and Euphorbia hirta using in-vitro and in-vivo rodent experimental models...
October 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29049523/oral-human-papillomavirus-infection-differences-in-prevalence-between-sexes-and-concordance-with-genital-human-papillomavirus-infection-nhanes-2011-to-2014
#4
Kalyani Sonawane, Ryan Suk, Elizabeth Y Chiao, Jagpreet Chhatwal, Peihua Qiu, Timothy Wilkin, Alan G Nyitray, Andrew G Sikora, Ashish A Deshmukh
Background: The burden of human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is disproportionately high among men, yet empirical evidence regarding the difference in prevalence of oral HPV infection between men and women is limited. Concordance of oral and genital HPV infection among men is unknown. Objective: To determine the prevalence of oral HPV infection, as well as the concordance of oral and genital HPV infection, among U.S...
October 17, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29048785/-determination-of-34-illegally-adulterated-weight-loss-compounds-in-foods-by-ultra-high-performance-liquid-chromatography-triple-quadrupole-mass-spectrometry
#5
Qing Hu, Jian Sun, Rui Feng, Su Zhang, Hong Yu, Jingxian Zhang, Xiuhong Mao, Shen Ji
An analytical method was developed for the determination of 34 illegally adulterated weight loss compounds in foods and dietary supplements by ultra high performance liquid chromatography-triple quadrupole mass spectrometry (UHPLC-MS/MS). A Waters CORTECS T3 column (100 mm×2.1 mm, 2.7 μm) was used with 0.1% (v/v) formic acid aqueous solution-acetonitrile containing 0.1% (v/v) formic acid as mobile phases by gradient elution. The compounds were detected by electrospray ion source in positive or negative mode with multiple reaction monitoring (MRM) mode...
June 8, 2017: Se Pu, Chinese Journal of Chromatography
https://www.readbyqxmd.com/read/29048711/rotavirus-virus-like-particles-rv-vlps-vaccines-an-update
#6
REVIEW
Harish Changotra, Avni Vij
Rotaviruses (RVs) cause over 0.2 million deaths annually and are reported to be the foremost cause of gastroenteritis in infants and children worldwide. Vaccination against RVs is the most successful and unsurpassed strategy to combat infection to date. Although the 2 current vaccines, Rotarix and RotaTeq, have dramatically reduced the disease burden, still there is a need for new vaccines. In this context, RV virus-like particles (RV-VLPs) represent potential vaccine candidates as they are noninfectious and effective nonreplicating immunogens that may reduce the risk of side effects related to the conventional vaccines...
October 19, 2017: Reviews in Medical Virology
https://www.readbyqxmd.com/read/29048560/targeting-the-mesenchymal-subtype-in-glioblastoma-and-other-cancers-via-inhibition-of-diacylglycerol-kinase-alpha
#7
Inan Olmez, Shawn Love, Aizhen Xiao, Laryssa Manigat, Peyton Randolph, Brian D McKenna, Brian P Neal, Salome Boroda, Ming Li, Breanna Brenneman, Roger Abounader, Desiree Floyd, Jeongwu Lee, Ichiro Nakano, Jakub Godlewski, Agnieszka Bronisz, Erik P Sulman, Marty Mayo, Daniel Gioeli, Michael Weber, Thurl E Harris, Benjamin Purow
Background: The mesenchymal phenotype in glioblastoma (GBM) and other cancers drives aggressiveness and treatment resistance, leading to therapeutic failure and recurrence of disease. Currently, there is no successful treatment option available against the mesenchymal phenotype. Methods: We classified patient-derived GBM stem cell lines into 3 subtypes: proneural, mesenchymal, and other/classical. Each subtype's response to the inhibition of diacylglycerol kinase alpha (DGKα) was compared both in vitro and in vivo...
June 29, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/29048513/sepsis-national-hospital-inpatient-quality-measure-sep-1-multistakeholder-work-group-recommendations-for-appropriate-antibiotics-for-the-treatment-of-sepsis
#8
Edward J Septimus, Craig M Coopersmith, Jessica Whittle, Caleb P Hale, Neil O Fishman, Thomas J Kim
The Center for Medicare and Medicaid Services adopted the Early Management Bundle, Severe Sepsis/Septic Shock (SEP-1) performance measure to the Hospital Inpatient Quality Reporting Program in July 2015 to help address the high mortality and high cost associated with sepsis. The SEP-1 performance measure requires, among other critical interventions, timely administration of antibiotics to patients with sepsis or septic shock. The multistakeholder workgroup recognizes the need for SEP-1 but strongly believes that multiple antibiotics listed in the antibiotic tables for SEP-1 are not appropriate and the use of these antibiotics, as called for in the SEP-1 measure, is not in alignment with prudent antimicrobial stewardship...
October 16, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29046636/targeting-the-immune-system-with-plant-lectins-to-combat-microbial-infections
#9
REVIEW
Jannyson J B Jandú, Roberval N Moraes Neto, Adrielle Zagmignan, Eduardo M de Sousa, Maria C A Brelaz-de-Castro, Maria T Dos Santos Correia, Luís C N da Silva
The arsenal of drugs available to treat infections caused by eukaryotic and prokaryotic microbes has been declining exponentially due to antimicrobial resistance phenomenon, leading to an urgent need to develop new therapeutic strategies. Host-directed immunotherapy has been reported as an attractive option to treat microbial infections. It consists in the improvement of host defenses by increasing the expression of inflammatory mediators and/or controlling of inflammation-induced tissue injury. Although the in vitro antimicrobial and immunomodulatory activities of lectins have been extensively demonstrated, few studies have evaluated their in vivo effects on experimental models of infections...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29046449/gga-mir-130b-suppresses-infectious-bursal-disease-virus-replication-via-targeting-the-viral-genome-and-cellular-socs5
#10
Mengjiao Fu, Bin Wang, Xiang Chen, Zhiyuan He, Yongqiang Wang, Xiaoqi Li, Hong Cao, Shijun J Zheng
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression post transcriptionally through silencing or degrading its targets, playing important roles in immune response. However, the role of miRNAs in host response against infectious bursal disease virus (IBDV) infection is not clear. In this study, we show that the expression of a series of miRNAs was significantly altered in DF-1 cells after infectious bursal disease virus (IBDV) infection. We found that gga-miR-130b inhibited IBDV replication via targeting the specific sequence of IBDV segment A and enhanced the expression of IFN-β by targeting Suppressors of Cytokine Signaling 5(SOCS5) in host cells...
October 18, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29046433/a-multimechanistic-antibody-targeting-the-receptor-binding-site-potently-cross-protects-against-influenza-b-viruses
#11
Chenguang Shen, Junyu Chen, Rui Li, Mengya Zhang, Guosong Wang, Svetlana Stegalkina, Limin Zhang, Jing Chen, Jianli Cao, Xingjian Bi, Stephen F Anderson, Timothy Alefantis, Minwei Zhang, Xiaoyang Cai, Kunyu Yang, Qingbing Zheng, Mujing Fang, Hai Yu, Wenxin Luo, Zizheng Zheng, Quan Yuan, Jun Zhang, James Wai-Kuo Shih, Harry Kleanthous, Honglin Chen, Yixin Chen, Ningshao Xia
Influenza B virus causes considerable disease burden worldwide annually, highlighting the limitations of current influenza vaccines and antiviral drugs. In recent years, broadly neutralizing antibodies (bnAbs) against hemagglutinin (HA) have emerged as a new approach for combating influenza. We describe the generation and characterization of a chimeric monoclonal antibody, C12G6, that cross-neutralizes representative viruses spanning the 76 years of influenza B antigenic evolution since 1940, including viruses belonging to the Yamagata, Victoria, and earlier lineages...
October 18, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/29046408/-smart-diagnosis-of-parasites-using-smartphones
#12
Muhammad A Saeed, Abdul Jabbar
Accurate and rapid diagnosis is crucial in combating parasitic diseases that cause millions of deaths worldwide. However, the scarcity of specialized diagnostic equipment in low-to-middle income countries is one of the barriers in effective management of parasitic diseases, which warrants the need for alternative, inexpensive and point-of-care diagnostic tools. Due to their multiple built-in sensors, smartphones offer cost-effective alternative to expensive diagnostic devices. However, the use of smartphones in parasitic diagnoses remains in its infancy...
October 18, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29046394/recombinant-human-islet-amyloid-polypeptide-forms-shorter-fibrils-and-mediates-%C3%AE-cell-apoptosis-via-generation-of-oxidative-stress
#13
Richa Dubey, Pooja Minj, Nikita Malik, Devika M Sardesai, Shruti H Kulkarni, Jhankar D Acharya, Neel S Bhavesh, Shilpy Sharma, Ashutosh Kumar
Protein aggregation play an important role in many human diseases including Alzheimer's, Parkinson's and Type 2 diabetes mellitus (T2DM). Human islet amyloid polypeptide (hIAPP) forms amyloid plaques in pancreas of T2DM subjects that are involved in deteriorating islet function and in mediating β- cell apoptosis. However, the detailed mechanism of action, structure and nature of toxic hIAPP species responsible for this effect remains elusive till date mainly due to the high cost associated with the chemical synthesis of pure peptide required for these studies...
October 18, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/29045135/structural-basis-of-inhibition-of-er%C3%AE-coactivator-interaction-by-high-affinity-n-terminus-isoaspartic-acid-tethered-helical-peptides
#14
Mingsheng Xie, Hui Zhao, Qisong Liu, Yujia Zhu, Feng Yin, Yu-Jie Liang, Yanhong Jiang, Dong-Yuan Wang, Kuan Hu, Xuan Qin, Zi-Chen Wang, Yujie Wu, Naihan Xu, Xi-Yang Ye, Tao Wang, Zigang Li
Direct inhibition of the protein-protein interaction of ERα and its endogenous coactivators with a cell permeable stabilized peptide may offer a novel, promising strategy for combating ERα positive breast cancers. Here, we report the co-crystal structure of a helical peptide stabilized by a N-terminal unnatural cross-linked aspartic acid (TD) in complex with the ERα ligand binding domain(LBD). We designed a series of peptides and peptide 6 that showed direct and high-affinity binding to ERα with selective anti-proliferative activity in ERα positive breast cancer cells...
October 18, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29045123/polymyxin-b3-tobramycin-hybrids-with-pseudomonas-aeruginosa-selective-antibacterial-activity-and-strong-potentiation-of-rifampicin-minocycline-and-vancomycin
#15
Ronald Domalaon, Xuan Yang, Yinfeng Lyu, George G Zhanel, Frank M Schweizer
There is an urgent need to develop novel antibacterial agents able to eradicate drug-resistant Gram-negative pathogens such as Pseudomonas aeruginosa. Antimicrobial hybrids have emerged as a promising strategy to combat bacterial resistance, as a stand-alone drug but also as an adjuvant in combination with existing antibiotics. Herein, we report for the first time the synthesis and biological evaluation of polymyxin-aminoglycoside heterodimers composing of polymyxin B3 covalently linked to tobramycin via an aliphatic hydrocarbon linker...
October 18, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29045001/anti-inflammaging-effects-of-human-alpha-1-antitrypsin
#16
Ye Yuan, Benedetto DiCiaccio, Ying Li, Ahmed S Elshikha, Denis Titov, Brian Brenner, Lee Seifer, Hope Pan, Nurdina Karic, Mohammad A Akbar, Yuanqing Lu, Sihong Song, Lei Zhou
Inflammaging plays an important role in most age-related diseases. However, the mechanism of inflammaging is largely unknown, and therapeutic control of inflammaging is challenging. Human alpha-1 antitrypsin (hAAT) has immune-regulatory, anti-inflammatory, and cytoprotective properties as demonstrated in several disease models including type 1 diabetes, arthritis, lupus, osteoporosis, and stroke. To test the potential anti-inflammaging effect of hAAT, we generated transgenic Drosophila lines expressing hAAT...
October 17, 2017: Aging Cell
https://www.readbyqxmd.com/read/29044848/a-novel-approach-to-synthesis-a-dual-mode-luminescent-composite-pigment-for-uncloneable-high-security-codes-to-combat-counterfeiting
#17
Kanika -, Pawan Kumar, Satbir Singh, Bipin Kumar Gupta
We demonstrate a strategy to protect valuable items such as currency, pharmaceuticals, important documents etc. against counterfeiting by marking them with luminescent security codes. These luminescent security codes were printed by employing luminescent ink formulated from a cost effective dual mode luminescent composite pigment of Gd1.7Yb0.2Er0.1O3 and Zn0.98Mn0.02S phosphors using commercially available PVC Gold medium. In the composite, Gd1.7Yb0.2Er0.1O3 and Zn0.98Mn0.02S accounts for upconversion and downconversion processes, respectively...
October 17, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29044167/impact-of-heavy-metal-lead-stress-on-polyamine-levels-in-halomonas-bvr-1-isolated-from-an-industry-effluent
#18
Manasi, Sridev Mohapatra, N Rajesh, Vidya Rajesh
In living systems, environmental stress due to biotic and abiotic factors triggers the production of myriad metabolites as a potential mechanism for combating stress. Among these metabolites are the small polycationic aliphatic amine molecules - polyamines, which are ubiquitous in all living organisms. In this work, we demonstrate a correlation between cellular concentration of three major polyamines (putrescine, spermidine and spermine) with lead exposure on bacteria for a period of 6-24 h. We report that indigenously isolated Halomonas sp...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29043922/barriers-and-facilitators-to-dispensing-of-intranasal-naloxone-by-pharmacists
#19
Ludmila N Bakhireva, Adriana Bautista, Sandra Cano, Shikhar Shrestha, Amy M Bachyrycz, Theresa H Cruz
BACKGROUND: While misuse of prescription opioids has reached epidemic proportions, pharmacy-based preventive services to combat this epidemic are limited. The aims of this study were to identify barriers and facilitators to the dispensing of intranasal naloxone (INN) by pharmacists in New Mexico. METHODS: For this mixed methods study, a qualitative component (focus group) informed the development of a quantitative component (electronic survey) distributed to all pharmacists registered with the New Mexico Board of Pharmacy and practicing in the state...
October 18, 2017: Substance Abuse
https://www.readbyqxmd.com/read/29043663/nephrotoxicity-induced-by-cisplatin-intake-in-experimental-rats-and-therapeutic-approach-of-using-mesenchymal-stem-cells-and-spironolactone
#20
Mohamed M Elseweidy, Mervat E Askar, Sahar E Elswefy, Mohamed Shawky
Chronic kidney disease may lead to subsequent tissue fibrosis. However, many factors can combat injurious stimuli in these tissues aiming to repair, heal, and alleviate any disturbance. Chemokines release, migration of inflammatory cells to the affected site, and activation of fibroblasts for the production of extracellular matrix are commonly observed in this disease. In the last years, many studies have focused on spironolactone (SPL), a mineralocorticoid receptor antagonist, and its pharmacological effects...
October 17, 2017: Applied Biochemistry and Biotechnology
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