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https://www.readbyqxmd.com/read/28426655/glycosome-biogenesis-in-trypanosomes-and-the-de-novo-dilemma
#1
REVIEW
Sarah Bauer, Meredith T Morris
Trypanosomatid parasites, including Trypanosoma and Leishmania, are the causative agents of lethal diseases threatening millions of people around the world. These organisms compartmentalize glycolysis in essential, specialized peroxisomes called glycosomes. Peroxisome proliferation can occur through growth and division of existing organelles and de novo biogenesis from the endoplasmic reticulum. The level that each pathway contributes is debated. Current evidence supports the concerted contribution of both mechanisms in an equilibrium that can vary depending on environmental conditions and metabolic requirements of the cell...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28426654/mycetoma-a-global-medical-and-socio-economic-dilemma
#2
Ahmed H Fahal
No abstract text is available yet for this article.
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28426199/sequestering-soil-organic-carbon-a-nitrogen-dilemma
#3
Jan Willem van Groenigen, Chris van Kessel, Bruce A Hungate, Oene Oenema, David S Powlson, Kees Jan van Groenigen
No abstract text is available yet for this article.
April 20, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28426028/-groping-in-the-dark-unheard-pain-2
#4
D J F Lambregts-van Marrewijk
For a very severely mentally disabled, deaf and blind man, it was always very difficult to carry out dental check-ups, diagnosis and treatment, even with pharmacologic support. The man cannot communicate pain. When caries and calculus were diagnosed, the man was treated under general anaesthesia. During this treatment session he was also found to have severe periodontal disease and peri-apical problems. The legal representative of the patient was unavailable for consultation on changes to the pre-prepared preliminary treatment plan...
April 2017: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/28425313/moral-distress-among-school-nurses
#5
Shannon Baker Powell, Martha Keehner Engelke, Melvin S Swanson
School nurses are well positioned to provide care to a diverse population of school-age children, but their role and work environment can present a variety of moral dilemmas leading to moral distress. The purpose of this study is to identify the moral distress level that exists in school nurses and to describe its relationship to common moral dilemmas and school nurse characteristics. Data were collected through face-to-face attendance at school nurse meetings in North Carolina where 307 school nurses participated in the survey...
January 1, 2017: Journal of School Nursing: the Official Publication of the National Association of School Nurses
https://www.readbyqxmd.com/read/28425086/the-clinical-benefits-of-denosumab-for-prophylaxis-of-steroid-induced-osteoporosis-in-patients-with-pulmonary-disease
#6
Shigeo Ishiguro, Kentaro Ito, Shigenori Nakagawa, Osamu Hataji, Akihiro Sudo
Previous reports demonstrated that bone density decreased rapidly during the initial few months of steroid therapy and continued decreasing at a rate of 2 to 4% annually. Our data indicates that denosumab can also play a role in the treatment of osteoporosis in the steroid-taking population. INTRODUCTION: Respiratory physicians are often faced with the dilemma that long-term steroid use will deteriorate bone mineral density and quality. Previous reports demonstrated that bone density decreased 8 to 12% during the initial few months of steroid therapy then continued decreasing at a rate of 2 to 4% annually...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28424869/review-on-diagnosis-and-management-of-urolithiasis-in-pregnancy-an-esut-practical-guide-for-urologists
#7
REVIEW
Bhaskar K Somani, Athanasios Dellis, Evangellos Liatsikos, Andreas Skolarikos
PURPOSE: Management of urolithiasis in pregnancy can be challenging for most urologists with diagnostic and treatment dilemma to ensure the best outcome for both mother and fetus. We wanted to review the literature for urolithiasis in pregnancy with a practical management guide for urologists. METHODS: A non-systematic review of literature was carried out for all English language literature using Medline. To ensure a more comprehensive search, the review of diagnosis and management of pregnant patients with urolithiasis was carried out separately, by two authors independently...
April 19, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28423385/guidelines-for-the-management-of-diabetic-macular-edema-by-the-european-society-of-retina-specialists-euretina
#8
Ursula Schmidt-Erfurth, Jose Garcia-Arumi, Francesco Bandello, Karina Berg, Usha Chakravarthy, Bianca S Gerendas, Jost Jonas, Michael Larsen, Ramin Tadayoni, Anat Loewenstein
Diabetic retinal disease is envisioned to become the plague of the coming decades with a steep increase of worldwide diabetes incidence followed by a substantial rise in retinal disease. Improvements in diagnostic and therapeutic care have to cope with this dilemma in a clinically and socioeconomically efficient manner. Laser treatment has found a less destructive competitor in pharmacological treatments. As a consequence of recent rigorous clinical trials, laser photocoagulation is no longer recommended for the treatment of diabetic macular edema (DME), and anti-vascular endothelial growth factor therapy has emerged as first-line therapy...
April 20, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28422168/competitions-between-prosocial-exclusions-and-punishments-in-finite-populations
#9
Linjie Liu, Xiaojie Chen, Attila Szolnoki
Prosocial punishment has been proved to be a powerful mean to promote cooperation. Recent studies have found that social exclusion, which indeed can be regarded as a kind of punishment, can also support cooperation. However, if prosocial punishment and exclusion are both present, it is still unclear which strategy is more advantageous to curb free-riders. Here we first study the direct competition between different types of punishment and exclusion. We find that pool (peer) exclusion can always outperform pool (peer) punishment both in the optional and in the compulsory public goods game, no matter whether second-order sanctioning is considered or not...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28421074/immunometabolic-phenotype-alterations-associated-with-the-induction-of-disease-tolerance-and-persistent-asymptomatic-infection-of-salmonella-in-the-chicken-intestine
#10
REVIEW
Michael H Kogut, Ryan J Arsenault
The adaptation of Salmonella enterica to the eukaryotic host is a key process that enables the bacterium to survive in a hostile environment. Salmonella have evolved an intimate relationship with its host that extends to their cellular and molecular levels. Colonization, invasion, and replication of the bacteria in an appropriate host suggest that modification of host functions is central to pathogenesis. Intuitively, this subversion of the cell must be a complex process, since hosts are not inherently programmed to provide an environment conducive to pathogens...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28420786/memory-n-strategies-of-direct-reciprocity
#11
Christian Hilbe, Luis A Martinez-Vaquero, Krishnendu Chatterjee, Martin A Nowak
Humans routinely use conditionally cooperative strategies when interacting in repeated social dilemmas. They are more likely to cooperate if others cooperated before, and are ready to retaliate if others defected. To capture the emergence of reciprocity, most previous models consider subjects who can only choose from a restricted set of representative strategies, or who react to the outcome of the very last round only. As players memorize more rounds, the dimension of the strategy space increases exponentially...
April 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28420268/ethics-in-health-administration-a-practical-approach-for-decision-makers-3rd-edition
#12
David Brown
Ethics in Health Administration: A Practical Approach for Decision Makers (3rd ed.) is a four-section, 16-chapter book that provides health practitioners with practical applications to ethics in the health and helping professions. These applications provide health professionals with suggestions and recommendations to assist them with ethical issues and dilemmas.
May 2017: Health Promotion Practice
https://www.readbyqxmd.com/read/28420005/thiazide-associated-hyponatremia-a-major-dilemma-affecting-treatment
#13
Biff F Palmer, Deborah J Clegg
No abstract text is available yet for this article.
April 19, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28419773/non-invasive-follicular-neoplasm-with-papillary-like-nuclear-features-niftp-if-it-ain-t-broke-don-t-fix-it-the-cytopathologist-s-dilemma
#14
EDITORIAL
Virginia A LiVolsi, Lester Layfield, Zubair W Baloch
No abstract text is available yet for this article.
April 16, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28419609/band-aids-for-buchnera-and-b-vitamins-for-all
#15
Jacob A Russell, Kerry M Oliver, Allison K Hansen
Evolution lacks foresight, and hence, key adaptations may produce major challenges over the long run. The natural world is rife with examples of long-term 'side effects' associated with quick-fix tinkering, including blind spots in vertebrate eyes. An important question is how nature compensates for imperfections once evolution has set a course. The symbioses associated with sap-feeding insects present a fascinating opportunity to address this issue. On one hand, the substantial diversity and biomass of sap-feeding insects are largely due to ancient acquisitions of nutrient-provisioning bacterial symbionts...
April 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28418416/-dental-treatment-of-fearful-children-subjection-denyal-or-guidance
#16
M C M van Gemert-Schriks, M M Bildt
Dental treatment anxiety is a common fear among children. The dental health care provider is faced with difficult dilemmas about ensuring good oral health for these children in general daily practice. The indicated treatment usually exceeds the capacity of the frightened child, but when treatment is not performed, the child is at risk of serious general health problems and its quality of life could diminish. This article provides an overview of the aetiology of dental treatment anxiety in children. In addition, the dental practitioner is provided with insight into the possibilities that allow him/her to enhance the treatability of the child and reduce anxiety to such an extent that the indicated dental care can be provided...
April 2017: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/28418411/-groping-in-the-dark-unheard-pain-2
#17
D J F Lambregts-van Marrewijk
For a very severely mentally disabled, deaf and blind man, it was always very difficult to carry out dental check-ups, diagnosis and treatment, even with pharmacologic support. The man cannot communicate pain. When caries and calculus were diagnosed, the man was treated under general anaesthesia. During this treatment session he was also found to have severe periodontal disease and peri-apical problems. The legal representative of the patient was unavailable for consultation on changes to the pre-prepared preliminary treatment plan...
April 2017: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/28417980/is-active-surveillance-a-suitable-option-for-african-american-men-with-prostate-cancer-a-systemic-literature-review
#18
REVIEW
M I Gökce, D Sundi, E Schaeffer, C Pettaway
BACKGROUND: Certain patients presenting with either low or very-low-risk prostate cancer (PCa) can represent a therapeutic dilemma for physicians. The oncologic outcomes of active surveillance (AS) for men with very-low-risk PCa are overall excellent. However, there are concerns about AS related to the potential for upgrading or upstaging. The African American (AA) population is under-represented in studies evaluating AS outcomes and this is particularly important because of the unique epidemiology of PCa in AA men...
April 18, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28416953/response-evaluation-of-chemotherapy-for-lung-cancer
#19
REVIEW
Ki-Eun Hwang, Hak-Ryul Kim
Assessing response to therapy allows for prospective end point evaluation in clinical trials and serves as a guide to clinicians for making decisions. Recent prospective and randomized trials suggest the development of imaging techniques and introduction of new anti-cancer drugs. However, the revision of methods, or proposal of new methods to evaluate chemotherapeutic response, is not enough. This paper discusses the characteristics of the Response Evaluation Criteria In Solid Tumor (RECIST) version 1.1 suggested in 2009 and used widely by experts...
April 2017: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28416644/evaluation-of-different-estimation-methods-for-accuracy-and-precision-in-biological-assay-validation
#20
Binbing Yu, Harry Yang
Biological assays (bioassays) are procedures to estimate the potency of a substance by studying its effects on living organisms, tissues, and cells. Bioassays are essential tools for gaining insight into biologic systems and processes including, for example, the development of new drugs and monitoring environmental pollutants. Two of the most important parameters of bioassay performance are relative accuracy (bias) and precision. Although general strategies and formulas are provided in USP 〈1033〉, a comprehensive understanding of the definitions of bias and precision remain elusive...
April 17, 2017: PDA Journal of Pharmaceutical Science and Technology
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