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https://www.readbyqxmd.com/read/28346303/eccrine-syringofibroadenoma-in-association-with-acquired-epidermodysplasia-verruciformis
#1
Timothy Tan, Joan Guitart, Luzheng Lisa Liu, Joaquin C Brieva, Sapna Amin, Monica Rani, Pedram Gerami, Pedram Yazdan
A 75-year-old man with human immunodeficiency virus infection and numerous biopsy-proven warts for 10 years, refractory to cryosurgery, cimetidine, and topical imiquimod, presented with numerous pink to hypopigmented verrucous papules and plaques involving the face, trunk, buttocks, and groin. Laboratory evaluation revealed a CD4 T-cell count of 62 cells per microliter and human immunodeficiency virus viral load of <117 copies per milliliter. Biopsy of a plaque groin lesion was performed. Histopathology revealed vertically oriented anastomosing strands of basaloid epithelium arising from multiple points along the epidermis in a background fibrovascular stroma...
January 3, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28259234/primary-lymphedema-and-viral-warts-in-gata2-haploinsufficiency
#2
Juliana Perez Botero, Vilmarie Rodriguez
No abstract text is available yet for this article.
March 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28236614/treatment-of-athlete-s-plantar-warts-using-a-botanical-blend-a-case-report
#3
Erik O Nelson, Adam F Kozin, Guillermo Ruiz, Arben Lasku, Jeffrey O Langland
Context • Viral plantar warts, or verruca plantaris, are a benign epithelial tumor caused by various strains of the human papilloma virus (HPV). Current treatments have had mixed degrees of success, are moderately invasive, and are often incompatible with participation in sports. Objective • The study intended to examine the benefits of treating plantar warts with a topical, botanical blend that has had clinical success treating herpes simplex virus cold sores. Methods • A synergistic botanical blend was applied topically...
February 27, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28209722/long-term-outcome-of-hematopoietic-stem-cell-transplantation-for-il2rg-jak3-scid-a-cohort-report
#4
Intan Juliana Abd Hamid, Mary A Slatter, Fiona McKendrick, Mark S Pearce, Andrew R Gennery
Hematopoietic stem cell transplantation (HSCT) cures the T-lymphocyte, B-lymphocyte and Natural Killer (NK) cell differentiation defect in IL2RG/JAK3 SCID. We evaluated long-term clinical features, longitudinal immunoreconstitution, donor chimerism and quality of life (QoL) of IL2RG/JAK3 SCID patients >2 years post-HSCT at our center. Clinical data were collated and patients/families answered PedsQL Generic Core Scale v4.0 questionnaires. We performed longitudinal analyses of CD3+, CD4+ naïve T-lymphocyte, CD19+ and NK cell numbers from pre-transplant until 15 years post-transplant...
February 16, 2017: Blood
https://www.readbyqxmd.com/read/28196318/common-skin-conditions-in-children-skin-infections
#5
Brian Z Rayala, Dean S Morrell
Skin infections account for a significant subset of dermatologic conditions of childhood. Common cutaneous viral infections in children include warts, molluscum contagiosum, hand-foot-and-mouth disease, and herpes simplex. Although viral infections are self-limited and often only mildly symptomatic, they can cause anxiety, embarrassment, and health care use. Recognition of their common and atypical presentations is necessary to differentiate them from other skin conditions of similar morphology. Impetigo, cellulitis, and abscess comprise the majority of childhood bacterial skin infections and are treated with topical or systemic antibiotics that cover group A Streptococcus and Staphylococcus aureus...
February 2017: FP Essentials
https://www.readbyqxmd.com/read/28131060/proteomic-comparison-of-chelidonium-majus-l-latex-in-different-phases-of-plant-development
#6
Robert Nawrot, Rico Lippmann, Andrea Matros, Oskar Musidlak, Grzegorz Nowicki, Hans-Peter Mock
Chelidonium majus L. (Papaveraceae) latex is used in traditinonal folk medicine to treat papillae, warts, condylomas, which are visible effects of human papilloma virus (HPV) infections. The aim of this work was to provide new insights into the biology and medicinal use of C. majus milky sap in the flowering and fruit ripening period of the plant by comparing the protein content between samples collected on respective developmental stages using LC-MS-based label-free proteome approach. For quantification, the multiplexed LC-MS data were processed using comparative chemometric approach...
January 13, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28107605/creating-immunocompromised-districts
#7
K Ramey, J Ibrahim, R T Brodell
We read the letter to the editor, Viral warts and seborrheic keratosis on tattoos: a review of 9 cases with great interest.(1) Dermatologists see only what they know! Once we recognized the possibility that warts might grow preferentially in black and blue tattoo dye, we collected 7 cases over a 10-year period from one solo private practice. In this report, a patient with a pre-existing viral wart on skin adjacent to a new tattoo appears to have preferentially spread onto the immunocompromised district (Ruocco, 2009)(2) created by black ink nanoparticles...
January 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28107597/viral-warts-and-seborrheic-keratoses-on-tattoos-a-review-of-9-cases
#8
Nicolas Kluger
We wish to add to the recent article by Ramley et al(1) our experience on 8 cases of viral warts and one case of seborrheic keratosis (SK) on tattoos. Those cases were collected with the help of dermatologists and family doctors between 2007 and 2016. We reviewed the demographic data, delay of onset after tattooing, clinical presentation and outcomes whenever possible. The number of lesions was counted manually from the available pictures. This article is protected by copyright. All rights reserved.
January 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28099608/subungual-squamous-cell-carcinoma
#9
Carolina Barbosa de Sousa Padilha, Laila Klotz de Almeida Balassiano, Julyana Calegari Pinto, Flávia Crespo Schueler de Souza, Bernard Kawa Kac, Curt Mafra Treu
Although subungual squamous cell carcinoma is rare, it is the most common primary malignant neoplasms in this location. The higher incidence occurs in the fingernails, but involvement of the toenails is also possible. Subungual squamous cell carcinoma often looks like other more common benign lesions, such as fungal infection, onychomycosis, or viral wart. These factors, together with a general lack of awareness of this disease among physicians, often result in delayed diagnosis. Therefore, it is underdiagnosed, with few reports in the literature...
November 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28043196/clinico-epidemiological-profile-of-viral-sexually-transmitted-infections-in-seropositive-patients-attending-a-tertiary-care-hospital-in-north-india
#10
Shikha Chugh, Vijay Kumar Garg, Rashmi Sarkar, Kabir Sardana
Sexually transmitted diseases are a major public health problem both in developing and in developed countries, and especially with the co-synergy with HIV infection, there is an increasing need to have a proper understanding of the clinicodemographic patterns of sexually transmitted infections (STIs) for planning and implementing control strategies. Worldwide, there is an increased preponderance of viral STIs. Increasing incidence and altered clinical presentation of viral STIs in patients with HIV pose a diagnostic challenge; thereby, we studied the demographic profile of HIV-seropositive patients and compared clinical manifestations of viral STIs in HIV-seropositive patients to those in seronegative individuals...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28040475/the-low-risk-papillomaviruses
#11
REVIEW
Nagayasu Egawa, John Doorbar
Human Papillomavirus (HPV) research has been dominated by the study of a subset of Alpha papillomaviruses that together cause almost 5% of human cancers worldwide, with the focus being on the two most prominent of these (HPV16 and 18). These viruses are referred to as 'high-risk' (hrHPV), to distinguish them from the over 200 prevalent HPV types that more commonly cause only benign epithelial lesions. The 'low-risk' (lrHPV) term used to describe this group belies their cumulative morbidity. Persistent laryngeal papillomas, which occur rarely in children and adults, require regular surgical de-bulking to allow breathing...
March 2, 2017: Virus Research
https://www.readbyqxmd.com/read/28035074/activating-transcription-factor-3-is-crucial-for-antitumor-activity-and-to-strengthen-the-antiviral-properties-of-onconase
#12
Anna Vert, Jessica Castro, Marc Ribó, Antoni Benito, Maria Vilanova
Onconase is a ribonuclease that presents both antitumor and antiviral properties linked to its ribonucleolytic activity and represents a new class of RNA-damaging drugs. It has reached clinical trials for the treatment of several cancers and human papilloma virus warts. Onconase targets different RNAs in the cell cytosol but Onconase-treated cells present features that are different from a simple arrest of protein synthesis. We have used microarray-derived transcriptional profiling to identify Onconase-regulated genes in two ovarian cancer cell lines (NCI/ADR-RES and OVCAR-8)...
December 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/28006878/development-of-a-novel-multiplex-type-specific-quantitative-real-time-pcr-for-detection-and-differentiation-of-infections-with-human-papillomavirus-types-hpv2-hpv27-and-hpv57
#13
Lea Hošnjak, Kristina Fujs Komloš, Boštjan J Kocjan, Katja Seme, Mario Poljak
INTRODUCTION: The present study describes the development and evaluation of the first multiplex type-specific quantitative real-time PCR (RT-PCR), enabling simple, rapid, sensitive, and specific concurrent detection and differentiation of human papillomavirus (HPV) types HPV2, 27, and 57 in a single PCR reaction. RESULTS: The HPV2/27/57 multiplex RT-PCR with a dynamic range of seven orders of magnitude (discriminating 10 to 108 viral genome equivalents/reaction) has an analytical sensitivity of at least 10 viral copies of each targeted HPV type/reaction, and no cross-reactivities were observed among the included targets...
December 2016: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
https://www.readbyqxmd.com/read/27932663/genomic-sequence-of-canine-papillomavirus-19
#14
Michael J Tisza, Hang Yuan, Richard Schlegel, Christopher B Buck
It is generally assumed that individual papillomas (warts) are caused by infection with individual papillomavirus types. Deep sequencing of virions extracted from a canine oral papilloma revealed the presence of canine papillomavirus 1 (CPV1), CPV2, and a novel canine papillomavirus, CPV19. This suggests that papillomas sometimes harbor multiple viral species.
December 8, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27918748/the-cxcl12-cxcr4-signaling-pathway-a-new-susceptibility-factor-in-human-papillomavirus-pathogenesis
#15
Floriane Meuris, Laetitia Carthagena, Agnieszka Jaracz-Ros, Françoise Gaudin, Pasquale Cutolo, Claire Deback, Yuezhen Xue, Françoise Thierry, John Doorbar, Françoise Bachelerie
The productive human papillomavirus (HPV) life cycle is tightly linked to the differentiation and cycling of keratinocytes. Deregulation of these processes and stimulation of cell proliferation by the action of viral oncoproteins and host cell factors underlies HPV-mediated carcinogenesis. Severe HPV infections characterize the wart, hypogammaglobulinemia, infection, and myelokathexis (WHIM) immunodeficiency syndrome, which is caused by gain-of-function mutations in the CXCR4 receptor for the CXCL12 chemokine, one of which is CXCR41013...
December 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27890786/heat-increases-the-editing-efficiency-of-human-papillomavirus-e2-gene-by-inducing-upregulation-of-apobec3a-and-3g
#16
Yang Yang, Hexiao Wang, Xinrui Zhang, Wei Huo, Ruiqun Qi, Yali Gao, Gaofeng Zhang, Bing Song, Hongduo Chen, Xinghua Gao
Apolipoprotein B mRNA-editing catalytic polypeptide (APOBEC) 3 proteins have been identified as potent viral DNA mutators and have broad antiviral activity. In this study, we demonstrated that apolipoprotein B mRNA-editing catalytic polypeptide 3A (A3A) and A3G expression levels were significantly upregulated in human papillomavirus (HPV)-infected cell lines and tissues. Heat treatment resulted in elevated expression of A3A and A3G in a temperature-dependent manner in HPV-infected cells. Correspondingly, HPV-infected cells heat-treated at 44 °C showed accumulated G-to-A or C-to-T mutation in HPV E2 gene...
November 24, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27889943/a-clinicopathological-study-of-the-oral-lesions-of-cowden-disease
#17
Mariana Hammerschmidt, Silvia Vanessa Lourenço, Marcello Menta Simonsen Nico
BACKGROUND: Cowden disease is a multisystemic cancer predisposition disorder, inherited in an autosomal dominant pattern. Cutaneous and visceral lesions are either malignant tumours or are believed to represent hamartomatous growths. Mucocutaneous lesions are present on almost 100% of affected individuals. Nonetheless, some authors consider that the mucocutaneous manifestations of Cowden disease are, in reality, viral warts at distinct steps of evolution. There are only a few studies regarding the oral manifestations of Cowden disease...
November 7, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27852999/immunotherapy-in-viral-warts-with-intradermal-bacillus-calmette-guerin-vaccine-versus-intradermal-tuberculin-purified-protein-derivative-a-double-blind-randomized-controlled-trial-comparing-effectiveness-and-safety-in-a-tertiary-care-center-in-eastern-india
#18
Indrashis Podder, Sabari Bhattacharya, Vivek Mishra, Tushar Kanti Sarkar, Somodyuti Chandra, Amrita Sil, Santasmita Pal, Dhiraj Kumar, Abanti Saha, Koushik Shome, Debabrata Bandyopadhyay, Nilay Kanti Das
BACKGROUND: Current therapeutic modalities for viral warts are mostly ablative and are limited by high recurrence rates besides being unsuitable for numerous lesions. Immunotherapy has the potential to overcome these limitations. AIMS: The aim of this study was to compare the effectiveness and safety of Bacillus Calmette-Guerin vaccine versus tuberculin purified protein derivative in the immunotherapy of warts. METHODS: Patients received three doses of 0...
November 11, 2016: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/27791434/a-comparative-study-of-pulsed-dye-laser-versus-long-pulsed-nd-yag-laser-treatment-in-recalcitrant-viral-warts
#19
Yo Sup Shin, Eun Byul Cho, Eun Joo Park, Kwang Ho Kim, Kwang Joong Kim
BACKGROUND: Viral warts are common infectious skin disease induced by human papillomavirus (HPV). But the treatment of recalcitrant warts is still challenging. OBJECTIVE: In this study, we compared the effectiveness of pulsed dye laser (PDL) and long pulsed Nd:YAG (LPNY) laser in the treatment of recalcitrant viral warts. METHODS: We retrospectively analyzed the medical records of patients with recalcitrant warts treated with laser therapy between January 2013 and February 2016...
November 15, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27699526/hpv-in-head-and-neck-cancer-30%C3%A2-years-of-history
#20
REVIEW
Stina Syrjänen, Jaana Rautava, Kari Syrjänen
The interesting history of papillomavirus (PV) research has been reviewed before. The history of human papillomavirus (HPV) in head and neck region starts in 1901 when the contagious transmission of warty lesions into the mouth via oral sex was described, although the confirmation of their viral etiology had to wait until 1907. Ullman was the first to associate the human wart virus with laryngeal warts. Parsons and Kidd described the natural history of oral PV infections in rabbits already in 1942, but these findings were corroborated in humans only recently...
2017: Recent Results in Cancer Research
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