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https://www.readbyqxmd.com/read/29218494/efficacy-of-pulsed-dye-laser-treatment-for-common-warts-is-not-influenced-by-the-causative-hpv-type-a-prospective-study
#1
Yoseph Fichman, Assi Levi, Emmilia Hodak, Shlomit Halachmi, Sigal Mazor, Dana Wolf, Orit Caplan, Moshe Lapidoth
Verruca vulgaris (VV) is a prevalent skin condition caused by various subtypes of human papilloma virus (HPV). The most common causes of non-genital lesions are HPV types 2 and 4, and to a lesser extent types 1, 3, 26, 29, and 57. Although numerous therapeutic modalities exist, none is universally effective or without adverse events (AE). Pulsed dye laser (PDL) is a favorable option due to its observed efficacy and relatively low AE rate. However, it is not known which verrucae are most likely to respond to PDL, or whether the causative viral subtype influences this response...
December 7, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29204384/approach-to-a-child-with-primary-immunodeficiency-made-simple
#2
REVIEW
Dhrubajyoti Sharma, Ankur K Jindal, Amit Rawat, Surjit Singh
Primary immunodeficiency disorders (PIDs) are a group of disorders affecting the capability to fight against infection. These include defects in T cells and B cells affecting cell-mediated and humoral immunity, respectively, combined humoral and cell-mediated immunodeficiency, defects in phagocytosis, complement defects, and defects in cytokine or cytokine signalling pathways which are detrimental for immune function. Depending upon the type and severity, age at onset of symptoms can vary from neonatal period to late childhood...
November 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29202430/a-retrospective-audit-of-lesion-excision-and-rotation-skin-flap-for-the-treatment-of-intractable-plantar-keratosis
#3
REVIEW
Amir Saipoor, Anthony Maher, Lance Hogg
AIM: The purpose of this study was to evaluate the treatment of plantar skin lesions by excision and rotation skin flap closure with reference to patient satisfaction; patient reported outcomes and complication rates. METHOD: A retrospective audit of 54 consecutive patients who had undergone plantar lesion excision with rotation skin flap between May 2011 and November 2015 under the care of experienced consultant podiatric surgeons. A total of 36 patients were included in this study, 16 were lost to follow up, 2 patients were excluded due to non-related pathology...
September 28, 2017: Foot
https://www.readbyqxmd.com/read/29176795/the-full-transcription-map-of-mouse-papillomavirus-type-1-mmupv1-in-mouse-wart-tissues
#4
Xiang-Yang Xue, Vladimir Majerciak, Aayushi Uberoi, Bong-Hyun Kim, Deanna Gotte, Xiongfong Chen, Maggie Cam, Paul F Lambert, Zhi-Ming Zheng
Mouse papillomavirus type 1 (MmuPV1) provides, for the first time, the opportunity to study infection and pathogenesis of papillomaviruses in the context of laboratory mice. In this report, we define the transcriptome of MmuPV1 genome present in papillomas arising in experimentally infected mice using a combination of RNA-seq, PacBio Iso-seq, 5' RACE, 3' RACE, primer-walking RT-PCR, RNase protection, Northern blot and in situ hybridization analyses. We demonstrate that the MmuPV1 genome is transcribed unidirectionally from five major promoters (P) or transcription start sites (TSS) and polyadenylates its transcripts at two major polyadenylation (pA) sites...
November 27, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29161070/declines-in-anogenital-warts-among-age-groups-most-likely-to-be-impacted-by-human-papillomavirus-vaccination-united-states-2006-2014
#5
Elaine W Flagg, Elizabeth A Torrone
OBJECTIVES: To detect decreases in anogenital warts (AGW) among sex and age groups likely to be affected by human papillomavirus vaccination. METHODS: We estimated annual AGW prevalence during 2006 to 2014 using health care claims among US private health insurance enrollees aged 15 to 39 years. We derived AGW diagnoses using 1 of the following: (1) condylomata acuminata diagnosis, (2) viral wart diagnosis combined with a benign anogenital neoplasm diagnosis or destruction or excision of an anogenital lesion, or (3) AGW medication combined with a benign anogenital neoplasm diagnosis or destruction or excision of an anogenital lesion...
November 21, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/29155073/dynamics-of-hpv-viral-loads-reflect-the-treatment-effect-of-photodynamic-therapy-in-genital-warts
#6
Zhili Hu, Lishi Liu, Wenjing Zhang, Hui Liu, Junpeng Li, Lifen Jiang, Kang Zeng
BACKGROUND: Photodynamic therapy (PDT) has demonstrated good clinical cure rates and low recurrence rates in the treatment of genital warts. Human papillomavirus (HPV) genotypes and viral load assays can reflect the status of persistent or latent infection and serve as a predictor of infection clearance. METHODS: Specimens from 41 patients with HPV infection were obtained, and the HPV genotypes and viral load were analyzed using real-time polymerase chain reaction (PCR) assays...
November 15, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29144546/presence-of-infection-and-analysis-of-hpv-subtypes-in-girls-younger-than-9-years-old-attended-at-a-referral-service-in-esp%C3%A3-rito-santo-brazil
#7
Mariana Penha De Nadai Sartori, Lidiane Pignaton Agostini, Thaís Tristão Tovar, Raquel Silva Dos Reis, Raquel Spinassé Dettogni, Eldamária de Vargas Wolfgramm Dos Santos, Antônio Chambô Filho, Iúri Drumond Louro
PURPOSE: Human papillomavirus is found in adults and adolescents and is associated with genital warts and cervical cancer. However, it has been detected in girls younger than 10 years old. Currently, there are no prevention methods for this age group, since it is not considered a risk group. The aim of this study was to evaluate the presence of infection and HPV subtype in girls under 9 years old attended at a referral service in the State of Espírito Santo, Brazil. METHODS: Forty-three girls younger than 9 years old had gynecological brush samples collected from vulval and perineal/anal regions...
November 16, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/29057503/reply-to-correspondence-topical-ionic-contra-viral-therapy-comprised-of-digoxin-and-furosemide-as-a-potential-novel-treatment-approach-for-common-warts
#8
T van der Kolk, R Rissmann
We appreciate Dr Abdelmaksoud's thorough review of our manuscript (1) and would like to reply to the comments that were raised with this letter. First, it appears that the understanding is that the study describes the 'clinical response of common warts to a topical application of a fixed dose of 980 mg of the ICVT gel on the patients' lower back. It should be clarified that the main objective of this first-in-man study was evaluate the systemic exposure, safety and tolerability of ionic-contra-viral therapy (ICVT) (2)...
October 23, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29055137/reply-to-topical-ionic-contra-viral-therapy-comprised-of-digoxin-and-furosemide-as-a-potential-novel-treatment-approach-for-common-warts
#9
Ayman Abdelmaksoud
I read with great interest a preliminary study on new treatment for common warts conducted by Kolk et al.(1) The authors studied, for the first time, the clinical response of common warts to topical application of a fixed dose of 980 mg topical gel containing 0.125% (w/w) digoxin and 0.125% (w/w) furosemide for 7 consecutive days on the patients' lower back. Basically, topical therapy for a common dermatosis is generally welcomed particularly if showed a higher degree of safety profile and less potential off-target adverse effects...
October 21, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28980715/the-early-impact-of-human-papillomavirus-vaccination-on-anogenital-warts-in-qu%C3%A3-bec-canada
#10
Marc Steben, Najwa Ouhoummane, Caroline Rodier, Liliya Sinyavskaya, Paul Brassard
BACKGROUND: In Québec, Canada, a public school-based and catch-up HPV vaccination programs with the quadrivalent vaccine have been introduced in September 2008 for girls aged 9-17 years. We assessed the early impact of the HPV vaccination program on the incidence of anogenital warts (AGW) in the Quebec general population. METHODS: We used the provincial health administrative data of the Régie de l'assurance maladie du Québec (RAMQ). AGW were identified either through a prescription of podofilox, or a medical procedure code specific to AGW, or a diagnostic code for viral warts followed by a prescription of imiquimod or fluorouracil...
October 5, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28954520/topical-sandalwood-oil-for-common-warts
#11
Malika Haque, Daniel L Coury
The purpose of this study was to evaluate the effectiveness of sandalwood oil for cutaneous viral warts caused by human papillomavirus. Sandalwood oil was applied topically twice daily for 12 weeks to cutaneous warts on any area of the body. Data collected at each visit included measurement of wart size, photograph of the warts, and documentation of treatment compliance and any adverse reactions. Ten subjects were enrolled and received treatment. At the end of the study, 8 of 10 (80%) had complete resolution of all treated warts...
February 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28947407/skin-diseases-of-the-male-external-genitalia-in-the-tanlangai-hospital-in-brazzaville-congo
#12
E S Bayonne Kombo, A Gathse, R B Soussa, A W S Odzebe
To determine the frequency of diseases responsible for skin lesions of the male external genitalia. This descriptive retrospective study examined the medical records of patients older than 14 years treated for genital symptoms as outpatients at the Dermatology Department of Talangaï Hospital in Brazzaville in 2009-2011. Patients' sociodemographic, medical history, clinical, and laboratory data were collected on a standardized individual form. The data were processed with Epi Info 3.5.4 software. The records revealed 76 dermatoses of the male external genitalia treated in the three-year study period...
August 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28941263/epidermodysplasia-verruciformis-three-case-reports-and-a-brief-review
#13
Sharma Shruti, Fouzia Siraj, Avninder Singh, V Ramesh
Epidermodyplasia verruciformis (EV) is a rare heritable disease that is characterized by an increased susceptibility to infection with specific human papillomavirus (HPV) types due to a defect in cell-mediated immune response to HPV infection. Widespread infection with HPV is responsible for the development of wart-like lesions and pityriasis versicolor-like spots. These individuals have a lifelong risk of developing cutaneous malignancies, especially Bowen's disease and squamous cell carcinoma, mainly in sun-exposed parts...
September 2017: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
https://www.readbyqxmd.com/read/28871935/topical-imiquimod-is-an-effective-and-safe-drug-for-molluscum-contagiosum-in-children
#14
George Badavanis, Efstathia Pasmatzi, Alexandra Monastirli, Sophia Georgiou, Dionysios Tsambaos
Dear Editor, Molluscum contagiosum (MC) is a very common skin infection caused by a molluscipox virus gene of the poxvirus family. It usually occurs in young children, sexually active adults, and immunocompromised individuals. The typical clinical picture of this infection is characterized by asymptomatic flesh-colored, single or multiple papules, measuring 2-6 mm in diameter with a central umbilication that occur on the skin and the mucous membranes. In adults, the skin lesions are predominantly located in the genital region, whereas in children they are found on the trunk, the extremities, and the face...
July 2017: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28871932/a-12-year-old-girl-with-severe-plaque-psoriasis-and-down-syndrome-treated-successfully-with-etanercept
#15
Michał Adamczyk, Małgorzata Michalska-Jakubus, Dorota Krasowska
The association between Down syndrome and psoriasis is unclear. Immunological abnormalities that present in individuals with Down syndrome result in mild immune debilitation, thus the risk of infectious complications during immunosuppressive therapy might be higher in this group of patients. We present a case of 12-year-old girl with severe plaque psoriasis and Down syndrome, who was initially treated with cyclosporine with good response. However, the drug was withdrawn due to massive viral warts development and loss of efficacy...
July 2017: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28867768/keratinocyte-differentiation-dependent-human-papillomavirus-gene-regulation
#16
REVIEW
Sheila V Graham
Human papillomaviruses (HPVs) cause diseases ranging from benign warts to invasive cancers. HPVs infect epithelial cells and their replication cycle is tightly linked with the differentiation process of the infected keratinocyte. The normal replication cycle involves an early and a late phase. The early phase encompasses viral entry and initial genome replication, stimulation of cell division and inhibition of apoptosis in the infected cell. Late events in the HPV life cycle include viral genome amplification, virion formation, and release into the environment from the surface of the epithelium...
August 30, 2017: Viruses
https://www.readbyqxmd.com/read/28833595/topical-ionic-contra-viral-therapy-comprised-of-digoxin-and-furosemide-as-a-potential-novel-treatment-approach-for-common-warts
#17
T van der Kolk, M R Dillingh, R Rijneveld, E S Klaassen, M N C de Koning, S T P Kouwenhoven, R E Genders, J N Bouwes Bavinck, G Feiss, R Rissmann, J Burggraaf
BACKGROUND: DNA viruses such as HPV rely on K(+) influx for replication. Both digoxin and furosemide inhibit the K(+) influx by interacting with cell membrane ion co-transporters (Na(+) /K(+) -ATPase and Na(+) -K(+) -2Cl(-) co-transporter-1, respectively). We therefore hypothesized that these two compounds in a topical formulation may be valuable in the treatment of HPV-induced warts. This new approach is called Ionic Contra-Viral Therapy (ICVT). OBJECTIVE: To evaluate systemic exposure, safety and tolerability of ICVT with a combination of furosemide and digoxin after repeated topical application in subjects with common warts...
August 17, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28798073/the-human-papillomavirus-replication-cycle-and-its-links-to-cancer-progression-a-comprehensive-review
#18
REVIEW
Sheila V Graham
HPVs (human papillomaviruses) infect epithelial cells and their replication cycle is intimately linked to epithelial differentiation. There are over 200 different HPV genotypes identified to date and each displays a strict tissue specificity for infection. HPV infection can result in a range of benign lesions, for example verrucas on the feet, common warts on the hands, or genital warts. HPV infects dividing basal epithelial cells where its dsDNA episomal genome enters the nuclei. Upon basal cell division, an infected daughter cell begins the process of keratinocyte differentiation that triggers a tightly orchestrated pattern of viral gene expression to accomplish a productive infection...
September 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28761264/a-case-report-of-verruca-vulgaris-on-basis-of-alopecia-areata-successfully-treated-with-diphenylcyclopropenone
#19
Tugba Kevser Uzuncakmak, Mahmut Can Koska, Ayşe Serap Karadağ, Necmettin Akdeniz
Alopecia areata is an autoimmune skin disease which is usually characterized by patchy hair loss in effected regions. Diagnosis usually based on clinical findings and main treatment options include topical, intralesional, systemic corticosteroids, and topical immunotherapy. Verruca vulgaris is an infectious disease caused by human papillomavirus which is usually characterized by well-marginated hyperkeratotic papules or plaques. There are several treatment modalities such as physical and chemical destruction and topical immunotherapy...
January 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/28736973/plasmacytoid-dendritic-cells-and-type-i-interferon-in-the-immunological-response-against-warts
#20
D Saadeh, M Kurban, O Abbas
BACKGROUND: Plasmacytoid dendritic cells (pDCs) are the most potent producers of type I interferons (IFNs), and are involved in the pathogenesis of several cutaneous infectious (especially viral), inflammatory/autoimmune and neoplastic entities. Their role in the pathogenesis and regression of human papilloma virus (HPV)-induced skin lesions has not been well studied. AIM: To investigate pDC occurrence and activity in HPV-induced skin lesions, including inflamed and uninflamed warts as well as epidermodysplasia verruciformis (EDV)-associated lesions...
July 24, 2017: Clinical and Experimental Dermatology
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