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diabetic osteomyelitis

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https://www.readbyqxmd.com/read/29148070/growth-factors-for-diabetic-foot-ulcers-mixed-treatment-comparison-analysis-of-randomized-clinical-trials
#1
Kannan Sridharan, Gowri Sivaramakrishnan
AIMS: Topical growth factors accelerate wound healing in patients with diabetic foot ulcers (DFU). Due to the absence of head to head comparisons, we carried out Bayesian network meta-analysis to compare the efficacy and safety of growth factors. METHODS: Using an appropriate search strategy, randomized controlled trials on topical growth factors compared with standard of care in patients with DFU, were included. Proportion of patients with complete healing was the primary outcome...
November 17, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29126421/peroneal-artery-perforator-flap-for-the-treatment-of-chronic-lower-extremity-wounds
#2
Liang Cheng, Xiaqing Yang, Tingxiang Chen, Zhijie Li
BACKGROUND: Reconstruction of chronic lower extremity wounds remains challenging. These wounds are mainly associated with diabetes mellitus, infections, and osteomyelitis. Although several reconstructive techniques are available, the peroneal artery perforator flap has unique advantages. METHODS: In this study, we discuss our experiences with peroneal artery perforator flaps in 55 patients who had suffered from chronic lower limb wounds. The size of the defect, comorbidities, etiology, flap size, and complications were recorded and analyzed based on a retrospective chart review...
November 10, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29126044/medial-forefoot-fillet-flap-for-primary-closure-of-transmetatarsal-amputation-a-series-of-four-cases
#3
Eliezer Sidon, Shai Shemesh, Yoav Rosenthal, Snir Heller, Steven Velkes, Alon Burg
Amputation of the forefoot is a salvage procedure for several forefoot acute or chronic infection. A good, sensate and durable skin cover is important for quicker and better rehabilitation. The use of filleted flaps (or "spare parts technique") has been published in the past as a creative technique. The purpose of this article is to introduce a reproducible, pre-planned, technique that requires less creativity for the use of the "spare parts". The authors describe a case series of 4 patients with deep infection and osteomyelitis of the forefoot, without involvement of the medial skin that underwent two staged procedure for transmetatarsal amputation with medial forefoot fillet flap...
June 29, 2017: Foot
https://www.readbyqxmd.com/read/29104510/chronic-osteomyelitis-increases-the-incidence-of-type-2-diabetes-in-humans-and-mice
#4
Yicun Wang, Jun Wang, Zhantao Deng, Jiewen Jin, Hui Jiang, Jia Meng, Haidong Xu, Jianning Zhao, Guojing Sun, Hongbo Qian
Background: To compare the risk of type 2 diabetes (T2DM) between patients with and without chronic osteomyelitis (COM), both in humans and in mice, and to explore risk factors in COM patients who developed T2DM. Methods: One hundred seven patients with COM and 114 patients without COM were consecutively enrolled and retrospectively analysed. Clinical data concerning the time to develop diabetes, glucose metabolism, lipid metabolism, inflammatory factors, mental health and frequency of specialist visits were collected...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29096337/viability-of-permanent-pmma-spacer-with-combined-free-fasciocutaneous-tissue-transfer-for-failed-charcot-reconstruction-a-38-month-prospective-case-report
#5
Tammer Elmarsafi, John S Steinberg, Paul J Kim, Christopher E Attinger, Karen K Evans
INTRODUCTION: Charcot Neuroarthropathy is a complex lower extremity pathology which predisposes the afflicted limb to ulcerations, osteomyelitis, and risk of major amputation. Charcot Neuroarthropathy often requires osseous reconstruction, which can be complicated with osteomyelitis and hardware infection. When soft tissue and osseous deficits must be concomitantly addressed, the use of PMMA spacers can be combined with free tissue transfers. PRESENTATION OF CASE: 71year old Caucasian male with Diabetic Charcot Neuroarthopathy underwent osseous reconstruction with internal hardware...
October 4, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29091040/a-pilot-study-to-evaluate-the-effects-of-perfusion-decellularized-porcine-hepatic-derived-wound-matrix-on-difficult-to-heal-diabetic-foot-ulcers
#6
Robert Fridman, Jonathan Engelhardt
OBJECTIVE: The purpose of this prospective pilot study is to evaluate the effects of a novel perfusion-decellularized porcine hepatic-derived wound matrix (PDPHD-WM) on very difficult-to-heal diabetic foot ulcers (DFUs). MATERIALS AND METHODS: For the intent of this study, a very difficult-to-heal DFU is one with a duration > 3 months despite using at least 1 advanced healing modality. Seven patients were enrolled in the study for a length of 14 weeks, including a 2-week run-in phase of standard-of-care therapy with saline gel and offloading in a CAM walker...
October 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29058098/osteomyelitis-of-the-lower-extremity-pathophysiology-imaging-and-classification-with-an-emphasis-on-diabetic-foot-infection
#7
Jacob C Mandell, Bharti Khurana, Jeremy T Smith, Gregory J Czuczman, Varand Ghazikhanian, Stacy E Smith
Osteomyelitis is inflammation of the bone caused by an infectious organism, and is a difficult clinical problem. The pathophysiology, imaging, and classification of osteomyelitis are challenging, varying with the age of the patient (child versus adult), the chronicity of the infection (acute versus chronic), and the route of spread (hematogenous versus contiguous focus), as well as the immune and vascular status of the patient and affected region. The two most common classification schemes are those of Lew and Waldvogel, and Cierny and Mader...
October 20, 2017: Emergency Radiology
https://www.readbyqxmd.com/read/29057063/is-surgical-debridement-necessary-in-the-diabetic-foot-treated-with-photodynamic-therapy
#8
João Paulo Tardivo, Rodrigo Serrano, Lívia Maria Zimmermann, Leandro Luongo Matos, Mauricio S Baptista, Maria Aparecida Silva Pinhal, Álvaro N Atallah
Background: Diabetic patients are susceptible to developing foot ulcers with serious complications such as osteomyelitis and amputations. Treatment approaches are still empirical and the benefit of usual procedures such as surgical debridement has not been properly evaluated. Photodynamic Therapy (PDT) is a non-invasive and highly efficient method for the treatment of the diabetic foot, being able to eradicate the infection and to stimulate healing, decreasing considerably the amputation risk. In the day-to-day practice of our service, we have been faced with the question whether debridement is necessary before PDT...
2017: Diabetic Foot & Ankle
https://www.readbyqxmd.com/read/29028632/procalcitonin-as-a-diagnostic-and-prognostic-marker-in-diabetic-foot-infection-a-current-literature-review
#9
Dimitrios Velissaris, Nikolaos-Dimitrios Pantzaris, Christina Platanaki, Nikolina Antonopoulou, Charalampos Gogos
Diabetic foot ulcers (DFUs) are a very common cause of mortality and morbidity. The distinction between infected and non-infected DFU remains a very challenging task for clinicians in everyday practice. Even when infection is documented, the spectrum of diabetic foot infection is wide, ranging from cellulitis and soft tissue infection to osteomyelitis. Procalcitonin (PCT), a well-established sepsis biomarker, has been used in the diagnosis of several infections including osteomyelitis in patients with diabetes mellitus...
October 11, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/28988505/clinical-and-pharmacokinetic-drug-evaluation-of-delafloxacin-for-the-treatment-of-acute-bacterial-skin-and-skin-structure-infections
#10
REVIEW
Matteo Bassetti, Davide Pecori, Piergiorgio Cojutti, Elda Righi, Federico Pea
In the era of multi-drug resistant pathogens, the adequate treatment of skin and skin structure infections remains a challenge for clinicians. Delafloxacin, with its broad spectrum against Gram-positive, Gram-negative and anaerobic organisms, represents a new therapeutic option in this setting, especially when coverage of methicillin-resistant Staphylococcus aureus is required in the empirical or targeted approach. Areas covered: In this drug evaluation, the Authors have reviewed the pharmacokinetic and pharmacodynamic characteristics of delafloxacin...
November 2017: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/28978574/in-the-setting-of-paediatric-osteomyelitis-do-not-be-afraid-to-cast-an-eye
#11
Rebecca Anne Russell, Edina Moylett
The case commences with an innocuous right ankle injury (lateral malleolus), for which the patient, a 9-year-old boy, was placed in a temporary cast at his local hospital. Three days following this incident, the patient was diagnosed with new-onset type 1 diabetes mellitus. He was admitted to his local hospital with severe diabetic ketoacidosis appropriately treated and subsequently discharged c.1 week later clinically well. Approximately 1 week later, again he presented for a third time with a significant serosanguinous discharge from the site of the initial injury permeating through the temporary cast in place for c...
October 4, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28976835/use-of-cryopreserved-umbilical-cord-with-negative-pressure-wound-therapy-for-complex-diabetic-ulcers-with-osteomyelitis
#12
A Raphael, J Gonzales
OBJECTIVE: The objective of this study was to evaluate the combined use of cryopreserved human umbilical cord (cUC) allograft and negative pressure wound therapy (NPWT) in treating complex diabetic foot ulcers (DFUs) with bone exposure and osteomyelitis. These types of wound are known to carry a high morbidity and mortality. METHODS: A single-center, retrospective chart review was performed to assess the efficacy of the combined use of cUC with NPWT, by the same surgeon, to help promote the closure of complex DFUs presenting with biopsy-proven osteomyelitis...
October 1, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28972392/microbial-management-of-diabetic-foot-osteomyelitis
#13
Jean-Philippe Lavigne, Albert Sotto
No abstract text is available yet for this article.
October 3, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28966913/disseminated-pasteurella-multocida-infection-cellulitis-osteomyelitis-and-myositis
#14
Yasmin C Marcantonio, Prathit A Kulkarni, Shira Sachs, Kevin Ting, Jennifer Lee, Daniel Mendoza
A 67-year-old man with poorly controlled type II diabetes mellitus was evaluated for right lower extremity erythema and swelling and left-sided lower back pain. He was found to have Pasteurella multocida bacteremia; magnetic resonance imaging showed osteomyelitis of the lumbar spine with myositis in the adjacent left paraspinal muscles. He was initially treated with intravenous antibiotics and was later transitioned to oral amoxicillin. He recovered completely with six weeks of antimicrobial therapy.
2017: IDCases
https://www.readbyqxmd.com/read/28951333/complications-during-the-treatment-of-diabetic-foot-osteomyelitis
#15
Suzanne A V van Asten, Moez Mithani, Edgar J G Peters, Javier La Fontaine, Paul J Kim, Lawrence A Lavery
AIM: To identify complications of medical treatment in patients with diabetic foot osteomyelitis (DFO). METHODS: We reviewed 143 records of consecutive patients admitted with DFO, confirmed by bone histopathology or culture. Complications monitored included acute kidney injuries (AKI), development of methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE), gastrointestinal complications, and venous catheter related complications during a 12months follow-up period...
June 13, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28940152/osteomyelitis-risk-in-patients-with-transfemoral-amputations-treated-with-osseointegration-prostheses
#16
Jonatan Tillander, Kerstin Hagberg, Örjan Berlin, Lars Hagberg, Rickard Brånemark
BACKGROUND: Percutaneous anchoring of femoral amputation prostheses using osseointegrating titanium implants has been in use for more than 25 years. The method offers considerable advantages in daily life compared with conventional socket prostheses, however long-term success might be jeopardized by implant-associated infection, especially osteomyelitis, but the long-term risk of this complication is unknown. QUESTIONS/PURPOSES: (1) To quantify the risk of osteomyelitis, (2) to characterize the clinical effect of osteomyelitis (including risk of implant extraction and impairments to function), and (3) to determine whether common patient factors (age, sex, body weight, diabetes, and implant component replacements) are associated with osteomyelitis in patients with transfemoral amputations treated with osseointegrated titanium implants...
December 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28892986/diagnostic-accuracy-and-surgical-utility-of-mri-in-complicated-diabetic-foot
#17
Mayank Mahendra, Rahul Singh
INTRODUCTION: Diabetic foot complications pose a significant public health hazard and have negative effect on life quality. These complications are associated with increased risk of amputations and premature death. So focus is increasing on early treatment of complicated diabetic foot. AIM: To assess the diagnostic accuracy and surgical utility of MRI in complicated diabetic foot. MATERIALS AND METHODS: Thirty four complicated diabetic patients were evaluated prospectively...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28888478/mandibular-coronoidectomy-could-significantly-accelerate-the-healing-process-of-infratemporal-fossa-abscess
#18
Yi-Wen Liu, Krishna Prasad Regmi, Ming-Chao Ding, Yan Li, Lei Tian, Bo-Lei Cai
PURPOSE: Management of an infratemporal fossa abscess (IFA), which is a specific form of severe and advanced deep fascial space infection (DFI), is based mainly on traditional methods. The purpose of this study was to investigate the role of mandibular coronoidectomy in accelerating IFA healing. PATIENTS AND METHODS: This research is a single-center retrospective study composed of 23 patients with IFA. The predictor variables were gender, age, diabetes, severity score, and mandibular coronoidectomy...
August 17, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28866726/application-of-white-blood-cell-spect-ct-to-predict-remission-after-a-6-or-12%C3%A2-week-course-of-antibiotic-treatment-for-diabetic-foot-osteomyelitis
#19
Julien Vouillarmet, Myriam Moret, Isabelle Morelec, Paul Michon, Julien Dubreuil
AIMS/HYPOTHESIS: Diabetic foot osteomyelitis is a major risk factor for amputation. Medical treatment allows remission in 53-82% of cases. However, the optimal duration of antibiotic therapy remains controversial as a validated marker of osteomyelitis remission is lacking. The aim of this cohort study was to assess prospectively the remission rate of diabetic foot osteomyelitis medically treated using white blood cell (WBC)-single-photon emission computed tomography (SPECT)/computed tomography (CT) as a predictive marker of remission...
December 2017: Diabetologia
https://www.readbyqxmd.com/read/28862037/the-relationship-between-osteomyelitis-complication-and-drug-resistant-infection-risk-in-diabetic-foot-ulcer-a-meta-analysis
#20
Yin Chen, Hui Ding, Hua Wu, Hong-Lin Chen
In this study, we aimed to investigate the relationship between osteomyelitis complications and drug-resistant infection risk in diabetic foot ulcer. Searches of MEDLINE and ISI databases were performed for the studies. Odds ratios (ORs) for drug-resistant infection incidence were calculated for diabetic foot ulcer patients with or without osteomyelitis complications. Eleven studies (12 cohorts) with 1526 patients were included in this study. Meta-analysis showed that the summary OR was 3.343 (95% CI = 2.355-4...
September 2017: International Journal of Lower Extremity Wounds
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