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diabetic osteomyelitis

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https://www.readbyqxmd.com/read/29745908/local-use-of-granulocyte-macrophages-colony-stimulating-factor-in-treatment-of-chronic-diabetic-neuropathic-ulcer-case-review
#1
E Karlafti, Ch Savopoulos, A Hatzitolios, T Didangelos
One of the main causes of amputations in patients with Diabetes Mellitus patients is a chronic diabetic foot ulcer. The authors present a clinical case and discussion of a successful use of Granulocyte-Macrophages Colony Stimulating Factor (GM-CSF) treatment for the promotion of healing of a chronic diabetic foot ulcer. A 65 year-old woman was admitted to the Diabetes Center with complaints of a deep non-healing chronic foot ulcer for the last 18 months. At the examination a 5 cm ulcer on the plantar surface of the right foot was revealed...
April 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29744230/skull-base-osteomyelitis-from-otitis-media-presenting-as-the-collet-sicard-syndrome
#2
Wong-Kein Low, Hui-Ling Lhu
Skull base osteomyelitis can involve the jugular foramen and its associated cranial nerves resulting in specific clinical syndromes. The Collet-Sicard syndrome describes the clinical manifestations of palsies involving cranial nerves IX, X, XI, and XII. We present a rare atypical case of skull base osteomyelitis originating from infection of the middle ear and causing the Collet-Sicard syndrome. Caused by Pseudomonas aeruginosa and Klebsiella pneumoniae , this occurred in an elderly diabetic man subsequent to retention of a cotton swab in an ear with chronic suppurative otitis media...
2018: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/29725580/salient-features-and-outcomes-of-charcot-foot-an-often-overlooked-diabetic-complication-a-17-year-experience-at-a-diabetic-center-in-bangkok
#3
Yotsapon Thewjitcharoen, Jeeraphan Sripatpong, Wyn Parksook, Sirinate Krittiyawong, Sriurai Porramatikul, Taweesak Srikummoon, Somkiet Mahaudomporn, Soontaree Nakasatien, Thep Himathongkam
Background: Charcot foot is a rare but a serious diabetic condition. Recognition of this often overlooked condition to provide timely and proper management is important for a better prognosis. Limited data on Charcot foot was available in Asians. Aims: The aim of this study is to describe salient features and outcomes of Charcot foot in Thai patients. Method: We presented our experience of 40 cases of Charcot foot patients who were treated from 2000 to 2016 at Theptarin Hospital, Bangkok, Thailand...
March 2018: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/29695061/use-of-leukocyte-platelet-l-prf-rich-fibrin-in-diabetic-foot-ulcer-with-osteomyelitis-three-clinical-cases-report
#4
Alessandro Crisci, Giuseppe Marotta, Anna Licito, Edda Serra, Giulio Benincasa, Michela Crisci
In this study, the use of fibrin rich in leukocytes and platelets (L-PRF) was explored to heal osteomyelitis ulcers in a diabetic foot. The goal was to standardize the utilization of L-PRF in patients with osteomyelitis to direct it for healing. L-PRF was obtained autologously from the peripheral blood of the diabetic patients ( n = 3) having osteomyelitis and skin lesions for at least six months. The L-PRF and supernatant serum were inserted into the skin lesion to the bone after a surgical debridement. The evolution of lesions over time was analyzed...
April 24, 2018: Diseases (Basel)
https://www.readbyqxmd.com/read/29692532/emphysematous-osteomyelitis-report-of-two-cases-and-review-of-literature
#5
Sachin Khanduri, Meenu Singh, Aakshit Goyal, Simran Singh
Emphysematous osteomyelitis is a rare condition characterized by the presence of intraosseous gas. A prompt diagnosis is required for this disease to expedite management as it is a potentially fatal condition. Many comorbidities, such as malignancy, diabetes mellitus, alcohol abuse, Crohn's disease, and other etiologies causing immunosuppression, predispose to this condition. The causative organisms are generally anaerobes or members of Enterobacteriaceae family; however, the infection can be mono or polymicrobial...
January 2018: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/29688043/the-clinical-value-of-diffusion-weighted-magnetic-resonance-imaging-in-diabetic-foot-infection
#6
Mehmet Ali Eren, Ekrem Karakaş, Ayşe Nur Torun, Tevfik Sabuncu
BACKGROUND: Osteomyelitis is a common complication in the diabetic foot which can be concluded with amputation. The purpose of this study was to evaluate the role of diffusion-weighted MRI (DWI) in the diagnosis of osteomyelitis in the diabetic foot ulcer (DFU). METHODS: Thirty patients with type 2 diabetes mellitus having DFU were enrolled. DWI and conventional MRI were obtained. Apparent Diffusion Coefficient (ADC) measurements were made by transferring the images to the workstation...
April 24, 2018: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/29686570/emphysematous-osteomyelitis-of-the-forefoot
#7
Ahmed Abdelbaki, Neeraj Bhatt, Nishant Gupta, Shuo Li, Shady Abdelbaki, Yogesh Kumar
Emphysematous osteomyelitis is a very rare, potentially fatal infection that requires immediate diagnosis and prompt treatment. Emphysematous osteomyelitis is usually considered whenever intraosseous gas is detected on imaging. Most organisms implicated in emphysematous osteomyelitis are members of the Enterobacteriaceae family or anaerobes; sometimes the infection is polymicrobial. We report a case of emphysematous osteomyelitis of the forefoot in a 33-year-old man with type 1 diabetes mellitus.
January 2018: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/29644884/prospective-analysis-of-surgical-bone-margins-after-partial-foot-amputation-in-diabetic-patients-admitted-with-moderate-to-severe-foot-infections
#8
Brian M Schmidt, Jonathan B McHugh, Rajiv M Patel, James S Wrobel
BACKGROUND: Osteomyelitis is common in diabetic foot infections and medical management can lead to poor outcomes. Surgical management involves sending histopathologic and microbiologic specimens which guides future intervention. We examined the effect of obtainment of surgical margins in patients undergoing forefoot amputations to identify patient characteristics associated with outcomes. Secondary aims included evaluating interobserver reliability of histopathologic data at both the distal-to and proximal-to surgical bone margin...
April 1, 2018: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/29626020/bone-and-joint-infection
#9
Julia Colston, Bridget Atkins
Bone and joint infections include septic arthritis, prosthetic joint infections, osteomyelitis, spinal infections (discitis, vertebral osteomyelitis and epidural abscess) and diabetic foot osteomyelitis. All of these may present through the acute medical take. This article discusses the pathogenesis of infection and highlights the importance of taking a careful history and fully examining the patient. It also emphasises the importance of early surgical intervention in many cases. Consideration of alternative diagnoses, appropriate imaging and high-quality microbiological sampling is important to allow appropriate and targeted antimicrobial therapy...
March 2018: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/29623214/mandibular-osteomyelitis-due-to-raoultella-species
#10
Philip W Lam, Manal Tadros, Ignatius W Fong
Introduction: Raoultella is a genus of aerobic Gram-negative bacilli belonging to the family Enterobacteriaceae that are commonly found in water, soil and aquatic environments. With improved bacterial identification techniques, Raoultella species (namely R. planticola and R. ornithinolytica ) have been an increasingly reported cause of infections in humans. Case presentation: An 85-year-old man presented to hospital with a several-week history of left jaw pain and trismus...
March 2018: JMM Case Reports
https://www.readbyqxmd.com/read/29595101/orthopedic-aspects-of-the-diabetic-foot
#11
E J A Tijdens-Creusen, Paul C Jutte, W M H H Schoumakers, M M Van der Klauw, Marjan Wouthuyzen-Bakker
Background Diabetes Mellitus (DM) is a common medical condition affecting more than 6% of the world population. Besides well-known pathology like diabetic retinopathy and renal insufficiency, it carries important orthopedic implications, especially around the foot and ankle (diabetic foot). Focus This article focusses on the three major areas confronting the orthopedist: 1) changes in foot statics and biology leading to ulceration with or without osteomyelitis, 2) ankle fractures, particularly complications after a fracture and 3) Charcot foot...
March 28, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29574036/prognostic-scoring-system-for-patients-undergoing-reconstructive-foot-and-ankle-surgery-for-charcot-neuroarthropathy-the-charcot-reconstruction-preoperative-prognostic-score
#12
David Rettedal, Alissa Parker, Adam Popchak, Patrick R Burns
Charcot neuroarthropathy is a destructive process that occurs in patients with peripheral neuropathy, often due to poorly controlled diabetes mellitus. Surgical reconstruction can be necessary to provide a plantigrade foot that is wound free. A risk of major amputation exists after a Charcot event and after attempted reconstruction. We retrospectively reviewed the data from 34 patients (36 reconstructions) who had undergone reconstructive surgery for Charcot neuroarthropathy. The mean patient age was 56.44 years...
May 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29565957/association-of-higher-migraine-risk-among-female-and-younger-chronic-osteomyelitis-patients-evidence-from-a-taiwan-cohort-of-one-million
#13
Jiunn-Horng Chen, Shih-Chi Wu, Chih-Hsin Muo, Chia-Hung Kao, Chun-Hung Tseng, Chon-Haw Tsai
BACKGROUND: Inflammation may trigger migraine development through neurovascular reactions in the brain. Most of the migraine patients, particularly the younger ones, do not have any risk factors for this disease. Hence, we assessed whether chronic osteomyelitis (COM), a chronic inflammatory disease, increases the risk of migraine. OBJECTIVE: We aim to evaluate the risk of migraine among female and middle-age COM patients with a large patient sample. STUDY DESIGN: A retrospective cohort study was conducted in this study...
March 2018: Pain Physician
https://www.readbyqxmd.com/read/29564946/virulence-factor-genes-in-staphylococcus-aureus-isolated-from-diabetic-foot-soft-tissue-and-bone-infections
#14
Gerardo Víquez-Molina, Javier Aragón-Sánchez, Cristian Pérez-Corrales, Christian Murillo-Vargas, María Eugenia López-Valverde, Benjamin A Lipsky
The aim of this study is to describe the presence of genes encoding for 4 virulence factors (pvl, eta, etb, and tsst), as well as the mecA gene conferring resistance to beta-lactam antibiotics, in patients with diabetes and a staphylococcal foot infection. We have also analyzed whether isolates of Staphylococcus aureus from bone infections have a different profile for these genes compared with those from exclusively soft tissue infections. In this cross-sectional study of a prospectively recruited series of patients admitted to the Diabetic Foot Unit, San Juan de Dios Hospital, San José, Costa Rica with a moderate or severe diabetic foot infection (DFI), we collected samples from infected soft tissue and from bone during debridement...
March 1, 2018: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/29526940/emphysematous-osteomyelitis-of-the-spine-a-case-report-and-literature-review
#15
Ryohei Ono, Koji Uehara, Izumi Kitagawa
Emphysematous osteomyelitis is a rare but potentially fatal infection. It is caused by gas-forming organismsand is characterized by the presence of intraosseous gas. A 75-year-old woman with untreated diabetes mellitus presented with difficulty in moving and anorexia. Laboratory studies revealed inflammation, a urinary infection, and diabetic ketoacidosis. Klebsiella pneumoniae was detected in both urine and blood cultures. Computed tomography and magnetic resonance imaging revealed emphysematous lesions in the paravertebral soft tissue, spinal canal, and iliopsoas muscle, with intraosseous gas at L1 and L2...
March 9, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29501595/heel-wounds-predict-mortality-but-not-amputation-after-infrapopliteal-revascularization
#16
Abhisekh Mohapatra, Jon C Henry, Efthimios D Avgerinos, Rabih A Chaer, Steven A Leers, Aureline Boitet, Michael J Singh, Eric S Hager
BACKGROUND: Ischemic heel ulcerations are generally thought to carry a poor prognosis for limb salvage. We hypothesized that patients undergoing infrapopliteal revascularization for heel wounds, either bypass or endovascular intervention, would have lower wound healing rates and amputation-free survival (AFS) than patients with forefoot wounds. METHODS: A retrospective chart review was performed on patients who presented between 2006 and 2013 to our institution with ischemic foot wounds and infrapopliteal arterial disease and underwent either pedal bypass or endovascular tibial artery intervention...
March 6, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29491344/intracardiac-abscess-and-pacemaker-lead-infection-secondary-to-hematogenous-dissemination-of-methicillin-sensitive-staphylococcus-aureus-from-a-prior-diabetic-foot-ulcer-and-osteomyelitis
#17
Kristopher S Pfirman, Robel Haile
BACKGROUND Intracardiac abscesses are an unusual occurrence in developed countries. With the increase in use of implantable cardiac devices, the increase use of and advancements in antibiotics, and the longevity of patients with cardiac devices, one may expect an increase in such infections; however, case reports are rare. We are presenting a case in which hematogenous dissemination of methicillin-sensitive Staphylococcus aureus (MSSA) infection from a lower extremity diabetic ulcer propagated into an infected pacemaker lead and ultimately an intracardiac abscess of the right atrium...
March 1, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29484984/diabetic-foot-infection-the-role-of-pet-ct-imaging
#18
Elite Arnon-Sheleg, Zohar Keidar
Osteomyelitis in the diabetic foot can be difficult to diagnose and has serious consequences. Although 2-deoxy-2-[18F]-fluoro-D-glucose (FDG) positron emission tomography (PET) was traditionally used in oncology, it is emerging as a useful method in inflammatory and infectious entities. In this chapter, original research articles, meta-analyses, and reviews on the performance of FDG PET in diagnosing osteomyelitis in the diabetic foot will be discussed. In addition, PET available data in comparison to different imaging methods, different analysis methods, and impact of other co-existing conditions such as hyperglycemia, and long-term antibiotic treatment on the performance of FDG PET will be reviewed...
February 26, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29484983/new-imaging-tracers-for-the-infected-diabetic-foot-nuclear-and-optical-imaging
#19
Alfred O Ankrah, Hans C Klein, Philip H Elsinga
Diabetic foot infections (DFIs) are associated with increased morbidity, an economic burden on patients, their families and healthcare systems and increased mortality. Early diagnosis with prompt, appropriate and adequate treatment of the infected diabetic foot is crucial. The determination of DFIs, however, may be quite perplexing and invasive. Imaging is useful in the evaluation of certain cases of DFIs, especially in suspected instances with no overt clinical features, or in the diagnosis of osteomyelitis...
February 26, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29484982/leukocyte-imaging-of-the-diabetic-foot
#20
Chiara Lauri, Andor W J M Glaudemans, Alberto Signore
BACKGROUND: Diagnosing diabetic foot infection is often difficult, despite several available diagnostic methods. Amongst these, several imaging modalities exist to evaluate the diabetic foot in case of a suspected osteomyelitis. Nuclear Medicine, in particular, offers a variety of radiopharmaceuticals and techniques. Nowadays the gold standard radionuclide procedure, when an osteomyelitis is suspected, is represented by the use of radiolabelled leukocytes with either 99mTc-HMPAO or 111In-oxine...
February 26, 2018: Current Pharmaceutical Design
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