keyword
MENU ▼
Read by QxMD icon Read
search

Advanced glycation end products

keyword
https://www.readbyqxmd.com/read/28812216/an-overview-of-in-vitro-and-in-vivo-glycation-of-albumin-a-potential-disease-marker-in-diabetes-mellitus
#1
REVIEW
Km Neelofar, Jamal Ahmad
Non-enzymatic glycation of macromolecules, especially proteins leading to their oxidation is increased in diabetes mellitus due to hyperglycaemia and play an important role in associated complications of the disease. Protein glycation mostly occurs in intra chain lysine residues resulting in the formation of early stage Amadori products which are finally converted to advance glycation end products (AGEs). This review deals with the structural studies of in vitro and in vivo glycated human serum albumin (HSA)...
August 15, 2017: Glycoconjugate Journal
https://www.readbyqxmd.com/read/28811077/the-receptor-for-advanced-glycation-end-products-a-fuel-to-pancreatic-cancer
#2
REVIEW
Uzma Shahab, Mohd Kaleem Ahmad, Abbas Ali Mahdi, Mohd Waseem, Binish Arif, Moinuddin, Saheem Ahmad
The receptor for advanced glycation end products (RAGEs) was first illustrated in the year 1992. RAGE is a single-transmembrane and multi-ligand component of the immunoglobulin protein super family. The engagement of RAGE turns out to an establishment of numerous intracellular signalling mechanisms resulting in the progression and perpetuation of many types of cancer including, the pancreatic cancer. The present review primarily focuses on the multi-ligand activation of RAGEs leading to the downstream signalling cascade activation...
August 12, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28810553/evaluation-of-the-c-domain-of-heparanase-during-age-induced-macrophage-inflammatory-response
#3
Qiaojing Qin, Guang Xu, Weiwei Qi, Mei Guo, Zhaoxia Wang, Wangjie Xu, Zhongdong Qiao, Yong Gu, Jianying Niu
Diabetic vasculopathy is intensified by macrophage inflammation caused by advanced glycation end products (AGEs). Heparanase (HPA) is a unique endoglycosidase, which cleaves heparan sulfate proteoglycans (HSPGs) including syndecan-1 (Syn-1) to further stimulate macrophage cell migration and inflammation. The present study was planned to evaluated the role of C-domain (if any) of HPA in AGE inflammatory response in macrophages. Cell viability was assessed using MTT assay, migration assay, ELISA for tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) levels, mRNA expression by RT-PCR and heparan degrading enzyme assay for HPA activity...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28806218/hypoxemic-patients-with-bilateral-infiltrates-treated-with-high-flow-nasal-cannula-present-a-similar-pattern-of-biomarkers-of-inflammation-and-injury-to-acute-respiratory-distress-syndrome-patients
#4
Marina García-de-Acilu, Judith Marin-Corral, Antonia Vázquez, Laura Ruano, Mònica Magret, Ricard Ferrer, Joan R Masclans, Oriol Roca
OBJECTIVE: To examine whether patients with acute hypoxemia and bilateral opacities treated with high-flow nasal cannula and acute respiratory distress syndrome patients who were directly mechanically ventilated are similar in terms of lung epithelial, endothelial, and inflammatory biomarkers. DESIGN: Prospective, multicenter study. SETTING: ICUs at three university tertiary hospitals. PATIENTS: Intubated and nonintubated patients admitted to the ICU with acute hypoxemia (PaO2/FIO2 ≤ 300) and bilateral opacities...
August 10, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28804542/significant-association-of-trem-1-with-hmgb1-tlrs-and-rage-in-the-pathogenesis-of-insulin-resistance-in-obese-diabetic-populations
#5
Saravanan Subramanian, Pradeep K Pallati, Poonam Sharma, Devendra K Agrawal, Kalyana C Nandipati
Activated cell surface and intracellular receptors lead to insulin resistance in obesity. Among these receptors, triggering receptors expressed on myeloid cells (TREM)-1, toll like receptors (TLRs), and receptors for advanced glycation end products (RAGE) play a significant role in the induction of inflammatory response in innate immunity. TREM-1 potentially amplifies TLRs and RAGE synergistically with DNA-binding high-mobility group box 1 (HMGB-1). The objective of the study was to analyze the association between TREM-1/DAP12 and HMGB-1, RAGE and TLRs in obesity-induced insulin resistance...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28801574/intestinal-transepithelial-permeability-of-oxytocin-into-the-blood-is-dependent-on-the-receptor-for-advanced-glycation-end-products-in-mice
#6
Haruhiro Higashida, Kazumi Furuhara, Agnes-Mikiko Yamauchi, Kisaburo Deguchi, Ai Harashima, Seiichi Munesue, Olga Lopatina, Maria Gerasimenko, Alla B Salmina, Jia-Sheng Zhang, Hikari Kodama, Hironori Kuroda, Chiharu Tsuji, Satoshi Suto, Hiroshi Yamamoto, Yasuhiko Yamamoto
Plasma oxytocin (OT) originates from secretion from the pituitary gland into the circulation and from absorption of OT in mother's milk into the blood via intestinal permeability. However, the molecular mechanism underlying the absorption of OT remains unclear. Here, we report that plasma OT concentrations increased within 10 min after oral delivery in postnatal day 1-7 mice. However, in Receptors for Advanced Glycation End Products (RAGE) knockout mice after postnatal day 3, an identical OT increase was not observed...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28780382/dicarbonyls-induce-senescence-of-human-vascular-endothelial-cells
#7
Alexander Navarrete Santos, Kathleen Jacobs, Andreas Simm, Nicole Glaubitz, Rüdiger Horstkorte, Britt Hofmann
RATIONALE: Glyoxal (GO) and Methylglyoxal (MGO) are two dicarbonyls involved in the formation of advanced glycation end products (AGEs). Endothelial cells in the vessels are in constant contact with circulating AGEs and dicarbonyls. With this project, we aimed to elucidate the effect of GO and MGO on primary human vascular endothelial cells (HVECs). METHODS: Graft material from patients with coronary heart disease was used as HVECs source. HVECs were treated with different concentrations of GO and MGO...
August 2, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28780050/hesperidin-reverses-perivascular-adipose-mediated-aortic-stiffness-with-aging
#8
An Ouyang, Tyler B Garner, Bradley S Fleenor
We tested the hypothesis that hesperidin would reverse age-related aortic stiffness, perivascular adipose (PVAT) mediated-arterial stiffening and PVAT advanced glycation end-products (AGE) accumulation. Aortic pulse wave velocity (aPWV) and intrinsic mechanical stiffness, two measures of arterial stiffness, were assessed in C57BL/6 mice that were young (6months), old (27-29months), or old treated with hesperidin for 4weeks. Old compared with young mice had increased aPWV (444±10 vs. 358±8cm/s, P<0.05) and mechanical stiffness (6506±369 vs...
August 3, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28776910/antiglycation-and-anti-oxidant-efficiency-of-carnosine-in-the-plasma-and-liver-of-aged-rats
#9
İlknur Bingül, Zülbiye Yılmaz, A Fatih Aydın, Jale Çoban, Semra Doğru-Abbasoğlu, Müjdat Uysal
AIM: Increases in oxidative stress and advanced glycation end-products (AGE) formation play an important role in the pathogenesis of aging. Carnosine (CAR; β-alanyl-L-histidine) has anti-oxidant and antiglycating properties. We investigated the effect of CAR supplementation on AGE levels, and protein and lipid oxidation products in the serum and liver tissue in aged rats. METHODS: Young (3 months-of-age) and aged (20 months-of-age) rats were injected with CAR (250 mg/kg/daily; i...
August 4, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28776053/effect-of-spermine-derived-ages-on-oxidative-stress-and-polyamine-metabolism
#10
Ayumi Tsutsui, Ambara R Pradipta, Shinobu Kitazume, Naoyuki Taniguchi, Katsunori Tanaka
Non-enzymatic glycation between proteins and carbohydrates, such as advanced glycation end products (AGEs), are naturally occurring compounds implicated in aging and numerous degenerative diseases. Methyl glyoxal (MG), which is an intermediate of the AGE biosynthetic pathway, is known to react with primary amines of proteins to create a wide range of AGE modifications, such as carboxyethyl lysine (CEL) and methylglyoxal-derived lysine dimer (MOLD). As a means to investigate and probe the ROS production pathways of AGEs, low molecular weight compounds carboxyethyl spermine (CES) and methylglyoxal-derived spermine dimer (MOSD) were synthesized, which replace lysine with another highly nucleophilic biological amine, spermine (SPM)...
August 16, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28775380/rage-inhibition-reduces-acute-lung-injury-in-mice
#11
Raiko Blondonnet, Jules Audard, Corinne Belville, Gael Clairefond, Jean Lutz, Damien Bouvier, Laurence Roszyk, Christelle Gross, Marilyne Lavergne, Marianne Fournet, Loic Blanchon, Caroline Vachias, Christelle Damon-Soubeyrand, Vincent Sapin, Jean-Michel Constantin, Matthieu Jabaudon
The receptor for advanced glycation end-products (RAGE) is involved in inflammatory response during acute respiratory distress syndrome (ARDS). Growing body of evidence support strategies of RAGE inhibition in experimental lung injury, but its modalities and effects remain underinvestigated. Anesthetised C57BL/6JRj mice were divided in four groups; three of them underwent orotracheal instillation of acid and were treated with anti-RAGE monoclonal antibody (mAb) or recombinant soluble RAGE (sRAGE), acting as a decoy receptor...
August 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28771806/advanced-glycation-end-products-and-porphyromonas-gingivalis-lipopolysaccharide-increase-calprotectin-expression-in-human-gingival-epithelial-cells
#12
Yuka Hiroshima, Eijiro Sakamoto, Kaya Yoshida, Kaori Abe, Koji Naruishi, Takenori Yamamoto, Yasuo Shinohara, Jun-Ichi Kido, Carolyn L Geczy
Accumulation of advanced glycation end-products (AGEs) in periodontal tissues of patients with diabetes mellitus aggravates periodontitis, but the mechanisms are unknown. Calprotectin, a heterocomplex of S100A8 and S100A9 proteins, is a constitutive cytoplasmic component of healthy gingival epithelial cells. This study aimed at investigating the effects of AGE and Porphyromonas gingivalis lipopolysaccharide (PgLPS) on calprotectin expression in the human gingival epithelial cell line OBA-9. AGE and PgLPS increased the expression of S100A8 and S100A9 mRNAs, and AGE + PgLPS co-stimulation amplified their expression in OBA-9 cells...
August 3, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28769106/lipoxin-a4-and-its-analog-suppress-inflammation-by-modulating-hmgb1-translocation-and-expression-in-psoriasis
#13
Xinxin Liu, Xin Wang, Xiaoru Duan, Devesh Poorun, Juntao Xu, Song Zhang, Lu Gan, Mengwen He, Ke Zhu, Zhangyin Ming, Feng Hu, Hongxiang Chen
Psoriasis is a chronic inflammatory skin disease that affects 2-3% of the global population, and there is still no known possibility of a cure. Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties. BML-111 (5(S)-6(R)-7-trihydroxyheptanoic acid methyl ester), a lipoxin receptor agonist, has been previously confirmed to be equivalent to LXA4 in the anti-inflammatory processes. High mobility group box 1 (HMGB1) serves as an inflammatory cytokine when secreted extracellularly in psoriatic lesions and is involved in the development of psoriasis...
August 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28763872/-research-of-the-biomarkers-in-pulmonary-and-extrapulmonary-acute-respiratory-distress-syndrome
#14
Q Yang, Z Q Li, H B Lan, S S Xiong, S S Wang, C S Yan
Objective: To explore the biomarkers that applied to pulmonary acute respiratory distress syndrome (ARDS) and extrapulmonary ARDS respectively. Methods: A total of 49 eligible patients with ARDS were selected from Department of Respiratory intensive care unite (ICU) , Department of General ICU and Department of Emergency ICU, the Second Affiliated Hospital of Nanchang University, during April 2015 and February 2016, and divided into pulmonary ARDS group (n=26) and extrapulmonary ARDS group (n=23) according to primary causes...
July 11, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28761309/glyceraldehyde-derived-advanced-glycation-end-products-accumulate-faster-than-n-%C3%AE%C2%B5-carboxymethyl-lysine
#15
Mami Yokota, Marie Sekita, Yuri Okano, Hitoshi Masaki, Masayoshi Takeuchi, Yoshihiro Tokudome
No abstract text is available yet for this article.
August 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28760504/protection-against-rage-mediated-neuronal-cell-death-by-srage-secreting-human-mesenchymal-stem-cells-in-5xfad-transgenic-mouse-model
#16
Myeongjoo Son, Seyeon Oh, Hyunjin Park, Hyosang Ahn, Junwon Choi, Hyungho Kim, Hye Sun Lee, Sojung Lee, Hye-Jeong Park, Seung U Kim, Bonghee Lee, Kyunghee Byun
Alzheimer's disease (AD), which is the most commonly encountered neurodegenerative disease, causes synaptic dysfunction and neuronal loss due to various pathological processes that include tau abnormality and amyloid beta (Aβ) accumulation. Aβ stimulates the secretion and the synthesis of Receptor for Advanced Glycation End products (RAGE) ligand by activating microglial cells, and has been reported to cause neuronal cell death in amyloid beta1-42 treated rats and in mice with neurotoxin-induced Parkinson's disease...
July 28, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28760085/the-impact-of-rage-inhibition-in-animal-models-of-bacterial-sepsis-a-systematic-review-and-meta-analysis
#17
Xin Zhao, Yan-Nian Liao, Qian Huang
Objective To evaluate the impact of inhibition of the receptor for advanced glycation end products (RAGE) on the outcome of bacterial sepsis in animal models. Methods Relevant publications were identified by systematic searches of PubMed, ISI Web of Science and Elsevier-Scopus databases. Results A total of Eleven studies with moderate quality were selected for analysis. A meta-analysis of survival rates revealed a significant advantage of RAGE inhibition in comparison with controls (HR 0.67, 95% CI 0.52-0.86)...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28759844/circulating-soluble-receptor-for-advanced-glycation-end-product-cross-sectional-associations-with-cardiac-markers-and-subclinical-vascular-disease-in-older-men-with-and-without-diabetes
#18
S Goya Wannamethee, Paul Welsh, Olia Papacosta, Elizabeth A Ellins, Julian P J Halcox, Peter H Whincup, Naveed Sattar
BACKGROUND AND AIMS: The soluble receptor for advanced glycation end products (sRAGE) has been implicated in diabetic vascular complications. We have examined the association between sRAGE and cardiac markers [NT-proBNP and cardiac troponin T (cTnT)] and subclinical vascular markers in older men with and without diabetes. METHODS: We performed a cross-sectional study of 1159 men aged 71-92 years with no history of cardiovascular disease (myocardial infarction, stroke, heart failure, coronary artery bypass graft operation or angioplasty)...
July 12, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28756107/s100a12-cd36-axis-a-novel-player-in-the-pathogenesis-of-atherosclerosis
#19
Jamileh Farokhzadian, Parvin Mangolian Shahrbabaki, Vahid Bagheri
S100A12 is a member of the S100 family of EF-hand calcium-binding proteins and have a variety of intracellular and extracellular activities. It exerts its proinflammatory effects by binding to the receptor for advanced glycation end products (RAGE) and Toll-like receptor 4 (TLR4). CD36 is a class B scavenger receptor that acts as a fatty acid transporter. Both S100A12 and CD36 are implicated in vascular inflammation and atherosclerosis. It has recently been demonstrated that S100A12 binds with high affinity to CD36...
July 26, 2017: Cytokine
https://www.readbyqxmd.com/read/28755585/evaluation-of-asteraceae-herbal-extracts-in-the-management-of-diabetes-and-obesity-contribution-of-caffeoylquinic-acids-on-the-inhibition-of-digestive-enzymes-activity-and-formation-of-advanced-glycation-end-products-in%C3%A2-vitro
#20
Vítor Spínola, Paula C Castilho
The study was performed to assess, for the first time, the in vitro anti-diabetic potential of ten Asteraceae plant extracts to inhibit the activity of digestive enzymes (α-amylase, α-, β-glucosidases and lipase) responsible for hydrolysis/digestion of sugar and lipids. Prevention of advanced glycation end-products (AGEs) formation was evaluated in bovine serum albumin/ribose glycation reaction model. The phytochemical profiles and caffeoylquinic acids (CQAs) contents were determined for the methanolic extract of each plant...
July 26, 2017: Phytochemistry
keyword
keyword
5884
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"