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https://www.readbyqxmd.com/read/29542369/detection-of-feline-coronavirus-mutations-in-paraffin-embedded-tissues-in-cats-with-feline-infectious-peritonitis-and-controls
#1
Laura Sangl, Kaspar Matiasek, Sandra Felten, Stefanie Gründl, Michele Bergmann, Hans-Jörg Balzer, Nikola Pantchev, Christian M Leutenegger, Katrin Hartmann
Objectives The amino acid substitutions M1058L and S1060A in the spike protein of feline coronavirus (FCoV) have been postulated to be responsible for the development of the pathogenic feline infectious peritonitis virus (FIPV), which causes feline infectious peritonitis (FIP). The aim of the following study was to investigate the presence of mutated virus in tissue samples of cats with and without FIP. Methods The study population consisted of 64 cats, 34 of which were diagnosed with FIP and 30 control cats...
March 1, 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29540320/detection-of-feline-coronavirus-in-effusions-of-cats-with-and-without-feline-infectious-peritonitis-using-loop-mediated-isothermal-amplification
#2
Sonja Günther, Sandra Felten, Gerhard Wess, Katrin Hartmann, Karin Weber
Feline infectious peritonitis (FIP) is a fatal disease in cats worldwide. The aim of this study was to test two commercially available reaction mixtures in a reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay to detect feline Coronavirus (FCoV) in body cavity effusions of cats with and without FIP, in order to minimize the time from sampling to obtaining results. RNA was extracted from body cavity effusion samples of 71 cats, including 34 samples from cats with a definitive diagnosis of FIP, and 37 samples of control cats with similar clinical signs but other confirmed diseases...
June 2018: Journal of Virological Methods
https://www.readbyqxmd.com/read/29517855/immunohistochemical-characterization-of-feline-lymphoplasmacytic-anterior-uveitis
#3
Lawrence Crossfield, Luca Fortuna, Rebekah Carling, Emma Scurrell, Marian Matas Riera, Yu-Mei Chang, Charlotte Dawson, Rachael Pittaway, Ian Yl Yeung, Caroline Thaung, Simon L Priestnall, Oliver A Garden
OBJECTIVE: To characterize the immune cells present in different forms of feline anterior uveitis. SAMPLES: Eyes were obtained from 49 cats diagnosed with chronic idiopathic lymphoplasmacytic anterior uveitis, 7 cats with feline infectious peritonitis (FIP), and 9 cats euthanized for nonocular disease. METHODS: H&E sections were scored on the level of infiltrate in the anterior uvea. Immunohistochemistry was performed for FoxP3, CD3, and IL-17A, and positive cells were quantified in multiple images of each sample...
March 8, 2018: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29478397/diagnosis-of-feline-infectious-peritonitis-update-on-evidence-supporting-available-tests
#4
Séverine Tasker
Practical relevance: Feline coronavirus (FCoV) infection is very common in cats, usually causing only mild intestinal signs such as diarrhoea. Up to 10% of FCoV infections, however, result in the fatal disease feline infectious peritonitis (FIP). Clinical challenges: Obtaining a definitive diagnosis of FIP based on non-invasive approaches is difficult. Confirmation of the disease relies on finding appropriate cytological or histopathological changes in association with positive immunostaining for FCoV antigen...
March 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29429403/comparison-of-the-performance-of-laboratory-tests-in-the-diagnosis-of-feline-infectious-peritonitis
#5
Angelica Stranieri, Alessia Giordano, Saverio Paltrinieri, Chiara Giudice, Valentina Cannito, Stefania Lauzi
We compared the performance of clinicopathologic and molecular tests used in the antemortem diagnosis of feline infectious peritonitis (FIP). From 16 FIP and 14 non-FIP cats, we evaluated retrospectively the sensitivity, specificity, and likelihood ratios (LRs) of serum protein electrophoresis, α1 -acid glycoprotein (AGP) on peripheral blood, screening reverse-transcription nested PCR (RT-nPCR) on the 3'-untranslated region (3'-UTR), and spike (S) gene sequencing on peripheral blood, body cavity effusions, and tissue, as well as body cavity cytology and delta total nucleated cell count (ΔTNC)...
May 2018: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29411701/a-retrospective-study-of-the-neuropathology-and-diagnosis-of-naturally-occurring-feline-infectious-peritonitis
#6
Daniel R Rissi
Feline infectious peritonitis (FIP) is one of the most important viral diseases of cats worldwide. Our study describes the neuropathology and the diagnostic features of 26 cases of FIP in domestic cats. The average age of affected individuals was 11.8 mo, and there was no sex or breed predisposition. Clinical neurologic signs were noted in 22 cases, and rabies was clinically suspected in 11 cases. Twenty cats had lesions in multiple organs, and 6 cats had lesions only in the brain. Gross neuropathologic changes occurred in 15 cases and consisted of hydrocephalus (10 cases), cerebellar herniation through the foramen magnum (6 cases), cerebral swelling with flattening of gyri (2 cases), and accumulation of fibrin within ventricles (2 cases) or leptomeninges (1 case)...
May 2018: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29118313/feline-coronavirus-antibody-titer-in-cerebrospinal-fluid-from-cats-with-neurological-signs
#7
Takehisa Soma, Namiko Saito, Masato Kawaguchi, Kazumi Sasai
To investigate the utility of cerebrospinal fluid (CSF) anti-feline coronavirus (FCoV) antibody test for diagnosis of feline infectious peritonitis (FIP), the antibody titers were tested in CSF and sera from 271 FIP-suspected neurological cats. CSF antibody was detected in 28 cats, which were divided into 2 groups; 15 with CSF titer of 1:80 or lower and 13 with CSF titer of 1:640 or higher. In the latter group, reciprocal serum titer/reciprocal CSF titer was 8 or lower, which is extremely lower than normal range (256-2048), and FCoV RNA was detected in all of 11 CSF samples assayed by RT-PCR...
January 1, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29113645/discrepancies-between-feline-coronavirus-antibody-and-nucleic-acid-detection-in-effusions-of-cats-with-suspected-feline-infectious-peritonitis
#8
Eleonora Lorusso, Viviana Mari, Michele Losurdo, Gianvito Lanave, Adriana Trotta, Giulia Dowgier, Maria Loredana Colaianni, Andrea Zatelli, Gabriella Elia, Domenico Buonavoglia, Nicola Decaro
Intra-vitam diagnosis of feline infectious peritonitis (FIP) is a challenge for veterinary diagnosticians, since there are no highly specific and sensitive assays currently available. With the aim to contribute to fill this diagnostic gap, a total of 61 effusions from cats with suspected effusive FIP were collected intra-vitam for detection of feline coronavirus (FCoV) antibodies and RNA by means of indirect immunofluorescence (IIF) assay and real-time RT-PCR (qRT-PCR), respectively. In 5 effusions there was no evidence for either FCoV RNA or antibodies, 51 and 52 specimens tested positive by IIF and qRT-PCR, respectively, although antibody titres≥1:1600, which are considered highly suggestive of FIP, were detected only in 37 effusions...
October 31, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29065819/feline-infectious-peritonitis-immunohistochemical-features-of-ocular-inflammation-and-the-distribution-of-viral-antigens-in-structures-of-the-eye
#9
Natalia Ziółkowska, Katarzyna Paździor-Czapula, Bogdan Lewczuk, Elżbieta Mikulska-Skupień, Barbara Przybylska-Gornowicz, Kamila Kwiecińska, Hubert Ziółkowski
Feline infectious peritonitis (FIP) is a serious, widely distributed systemic disease caused by feline coronavirus (FCoV), in which ocular disease is common. However, questions remain about the patterns of ocular inflammation and the distribution of viral antigen in the eyes of cats with FIP. This study characterized the ocular lesions of FIP including the expression of glial fibrillary acidic protein and proliferating cell nuclear antigen by Müller cells in the retina in cases of FIP and to what extent macrophages are involved in ocular inflammation in FIP...
November 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/29026122/nanoparticulate-vacuolar-atpase-blocker-exhibits-potent-host-targeted-antiviral-activity-against-feline-coronavirus
#10
Che-Ming Jack Hu, Wei-Shan Chang, Zih-Syun Fang, You-Ting Chen, Wen-Lin Wang, Hsiao-Han Tsai, Ling-Ling Chueh, Tomomi Takano, Tsutomu Hohdatsu, Hui-Wen Chen
Feline infectious peritonitis (FIP), caused by a mutated feline coronavirus, is one of the most serious and fatal viral diseases in cats. The disease remains incurable, and there is no effective vaccine available. In light of the pathogenic mechanism of feline coronavirus that relies on endosomal acidification for cytoplasmic entry, a novel vacuolar ATPase blocker, diphyllin, and its nanoformulation are herein investigated for their antiviral activity against the type II feline infectious peritonitis virus (FIPV)...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28982390/limitations-of-using-feline-coronavirus-spike-protein-gene-mutations-to-diagnose-feline-infectious-peritonitis
#11
Emily N Barker, Angelica Stranieri, Chris R Helps, Emily L Porter, Andrew D Davidson, Michael J Day, Toby Knowles, Anja Kipar, Séverine Tasker
Feline infectious peritonitis (FIP) is a fatal disease of cats, and a sequela of systemic feline coronavirus (FCoV) infection. Mutations in the viral spike (S) gene have been associated with FCoVs found in tissues from cats with FIP, but not FCoVs found in faeces from healthy cats, and are implicated in monocyte/macrophage tropism and systemic spread. This study was designed to determine whether S gene mutation analysis can reliably diagnose FIP. Cats were categorised as with FIP (n = 57) or without FIP (n = 45) based on gross post-mortem and histopathological examination including immunohistochemistry for FCoV antigen...
October 5, 2017: Veterinary Research
https://www.readbyqxmd.com/read/28901812/efficacy-of-a-3c-like-protease-inhibitor-in-treating-various-forms-of-acquired-feline-infectious-peritonitis
#12
Niels C Pedersen, Yunjeong Kim, Hongwei Liu, Anushka C Galasiti Kankanamalage, Chrissy Eckstrand, William C Groutas, Michael Bannasch, Juliana M Meadows, Kyeong-Ok Chang
Objectives The safety and efficacy of the 3C-like protease inhibitor GC376 was tested on a cohort of client-owned cats with various forms of feline infectious peritonitis (FIP). Methods Twenty cats from 3.3-82 months of age (mean 10.4 months) with various forms of FIP were accepted into a field trial. Fourteen cats presented with wet or dry-to-wet FIP and six cats presented with dry FIP. GC376 was administered subcutaneously every 12 h at a dose of 15 mg/kg. Cats with neurologic signs were excluded from the study...
September 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28833469/clinicopathologic-features-and-magnetic-resonance-imaging-findings-in-24-cats-with-histopathologically-confirmed-neurologic-feline-infectious-peritonitis
#13
A H Crawford, A L Stoll, D Sanchez-Masian, A Shea, J Michaels, A R Fraser, E Beltran
BACKGROUND: Feline infectious peritonitis (FIP) is the most common infectious central nervous system (CNS) disease in the cat and is invariably fatal. Improved means of antemortem diagnosis is required to facilitate clinical decision making. Information regarding the magnetic resonance imaging (MRI) findings of neurologic FIP currently is limited, resulting in the need for better descriptions to optimize its use as a diagnostic tool. OBJECTIVE: To describe the clinicopathologic features and MRI findings in cases of confirmed neurologic FIP...
September 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28780424/the-cholesterol-transport-inhibitor-u18666a-inhibits-type-i-feline-coronavirus-infection
#14
Tomomi Takano, Misaki Endoh, Hiroaki Fukatsu, Haruko Sakurada, Tomoyoshi Doki, Tsutomu Hohdatsu
Feline infectious peritonitis (FIP) is a feline coronavirus (FCoV)-induced fatal disease in wild and domestic cats. FCoV exists in two serotypes. Type I FCoV is the dominant serotype worldwide. Therefore, it is necessary to develop antiviral drugs against type I FCoV infection. We previously reported that type I FCoV is closely associated with cholesterol throughout the viral life cycle. In this study, we investigated whether U18666A, the cholesterol synthesis and transport inhibitor, shows antiviral effects against type I FCoV...
August 3, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28768514/sensitivity-and-specificity-of-a-real-time-reverse-transcriptase-polymerase-chain-reaction-detecting-feline-coronavirus-mutations-in-effusion-and-serum-plasma-of-cats-to-diagnose-feline-infectious-peritonitis
#15
Sandra Felten, Christian M Leutenegger, Hans-Joerg Balzer, Nikola Pantchev, Kaspar Matiasek, Gerhard Wess, Herman Egberink, Katrin Hartmann
BACKGROUND: Feline coronavirus (FCoV) exists as two pathotypes, and FCoV spike gene mutations are considered responsible for the pathotypic switch in feline infectious peritonitis (FIP) pathogenesis. The aim of this study was to evaluate sensitivity and specificity of a real-time reverse transcriptase polymerase chain reaction (RT-PCR) specifically designed to detect FCoV spike gene mutations at two nucleotide positions. It was hypothesized that this test would correctly discriminate feline infectious peritonitis virus (FIPV) and feline enteric coronavirus (FECV)...
August 2, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28493448/utility-of-an-immunocytochemical-assay-using-aqueous-humor-in-the-diagnosis-of-feline-infectious-peritonitis
#16
Sandra Felten, Kaspar Matiasek, Stefanie Gruendl, Laura Sangl, Katrin Hartmann
OBJECTIVE: In cats suffering from feline infectious peritonitis (FIP) without effusion, antemortem diagnosis is challenging. Uveitis is common in these cats. It was the aim of this study to evaluate sensitivity and specificity of an immunocytochemical assay (ICC) in aqueous humor of cats suspected of having FIP. ANIMALS STUDIED: The study included 26 cats with immunohistochemically confirmed FIP and 12 control cats for which FIP was suspected due to similar clinical or laboratory changes, but which suffered from other diseases confirmed via histopathology...
January 2018: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28491454/crossed-fused-renal-ectopia-in-a-persian-cat
#17
Sang-Hyuk Seo, Hyun-A Lee, Sang-Il Suh, Ran Choi, In-Chul Park, Changbaig Hyun
CASE SUMMARY: This report describes a rare case of crossed fused renal ectopia (CFRE) in a cat. A mature intact male Persian cat presented with bloody nasal discharge and ascites. Diagnostic studies revealed an ectopic left kidney fused with an orthotopic right kidney and a concurrent feline infectious peritonitis (FIP) infection. The FIP was responsible for clinical signs in this cat, while clinical signs associated with CFRE were not obvious. Despite receiving intensive treatment, the cat died...
January 2017: JFMS Open Reports
https://www.readbyqxmd.com/read/28425327/a-cross-sectional-quantitative-rt-pcr-study-of-feline-coronavirus-viremia-and-replication-in-peripheral-blood-of-healthy-shelter-cats-in-southern-california
#18
Eric J Fish, Pedro Paulo Vp Diniz, Yen-Chen Juan, Frank Bossong, Ellen W Collisson, Yvonne Drechsler, Bernhard Kaltenboeck
Objectives The objectives of this study were to determine the prevalence of feline coronavirus (FCoV) viremia, and its replication in peripheral blood using quantitative RT-PCR (qRT-PCR) methodology in a population of 205 healthy shelter cats in Southern California, as well as to assess any possible connection to longitudinal development of feline infectious peritonitis (FIP). Methods The study was performed on buffy-coat samples from EDTA-anticoagulated whole blood samples of 205 healthy shelter cats. From 50 of these cats, fecal samples were also examined...
April 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28388950/expression-profiles-of-immune-mediators-in-feline-coronavirus-infected-cells-and-clinical-samples-of-feline-coronavirus-positive-cats
#19
Nikoo Safi, Amin Haghani, Shing Wei Ng, Gayathri Thevi Selvarajah, Farina Mustaffa-Kamal, Abdul Rahman Omar
BACKGROUND: There are two biotypes of feline coronavirus (FCoV): the self-limiting feline enteric coronavirus (FECV) and the feline infectious peritonitis virus (FIPV), which causes feline infectious peritonitis (FIP), a fatal disease associated with cats living in multi-cat environments. This study provides an insight on the various immune mediators detected in FCoV-positive cats which may be responsible for the development of FIP. RESULTS: In this study, using real-time PCR and multiplex bead-based immunoassay, the expression profiles of several immune mediators were examined in Crandell-Reese feline kidney (CRFK) cells infected with the feline coronavirus (FCoV) strain FIPV 79-1146 and in samples obtained from FCoV-positive cats...
April 7, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28261584/polyprenyl-immunostimulant-treatment-of-cats-with-presumptive-non-effusive-feline-infectious-peritonitis-in-a-field-study
#20
Alfred M Legendre, Tanya Kuritz, Gina Galyon, Vivian M Baylor, Robert Eric Heidel
Feline infectious peritonitis (FIP) is a fatal disease with no clinically effective treatment. This field study evaluated treatment with Polyprenyl Immunostimulant (PI) in cats with the non-effusive form of FIP. Because immune suppression is a major component in the pathology of FIP, we hypothesized that treatment with an immune system stimulant would increase survival times of cats with dry FIP. Sixty cats, diagnosed with dry FIP by primary care and specialist veterinarians and meeting the acceptance criteria, were treated with PI without intentional selection of less severe cases...
2017: Frontiers in Veterinary Science
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