keyword
https://read.qxmd.com/read/38533815/a-novel-loop-mediated-isothermal-amplification-lamp-assay-to-diagnose-feline-panleukopenia
#1
JOURNAL ARTICLE
R A Bakde, R L Rathish, L John, P M Deepa, K Vijayakumar
Protoparvovirus carnivoran1 , known commonly as feline panleukopenia virus (FPV) is a highly contagious and environmentally stable parvovirus of domestic as well as wild felids. A rapid and robust diagnostic tool will aid in implementing prompt treatment and control measures. A loop-mediated isothermal amplification (LAMP) as a point-of-care diagnostic tool for diagnosing feline panleukopenia was standardised using faecal samples of cats. The assay will reduce the cost and time required to diagnose feline panleukopenia...
March 26, 2024: Journal of the South African Veterinary Association
https://read.qxmd.com/read/38500971/compound-c-inhibits-the-replication-of-feline-coronavirus
#2
JOURNAL ARTICLE
Yeonjeong Park, Chansoo Kim, Yea-In Park, Siyun Lee, Jaeyeon So, Rackhyun Park, Junsoo Park
Feline Coronavirus (FCoV) is a viral pathogen of cats and a highly contagious virus. Cats in a cattery can be infected by up to 100%, and even household cats are infected by 20-60%. Some strains of FCoV are known to induce a fatal disease in cats named Feline Infectious Peritonitis (FIP). However, no effective treatments are available. We demonstrated that compound C (dorsomorphin) can potentially inhibit feline coronavirus replication. Compound C treatment decreased the FCoV-induced plaque formation and cytopathic effect in FCoV-infected cells...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38479335/pathological-findings-and-patterns-of-feline-infectious-peritonitis-in-the-respiratory-tract-of-cats
#3
JOURNAL ARTICLE
Mônica Slaviero, Fernanda G Cony, Rodrygo C da Silva, Cíntia De Lorenzo, Bruno A de Almeida, Marianna Bertolini, David Driemeier, Saulo P Pavarini, Luciana Sonne
Feline infectious peritonitis (FIP) is an important cause of death in cats. Thoracic manifestations are less common than abdominal manifestations, and FIP-associated respiratory disease is poorly documented. This study aimed to investigate pathological findings in the respiratory tract of cats with FIP and the occurrence and distribution of feline coronavirus antigen in the respiratory tract using immunohistochemistry. A retrospective study was carried out on 112 cats with FIP, of which 66 had inflammatory histological lesions in the respiratory tract (58...
March 12, 2024: Journal of Comparative Pathology
https://read.qxmd.com/read/38376836/cross-sectional-and-histopathological-studies-of-feline-coronavirus-infections-in-stray-cats-in-kuwait
#4
JOURNAL ARTICLE
Nadra-Elwgoud M I Abdou, Maha K Al-Batel, Adawia A Henedi, Laila Z Al-Mutairi, Koshy Varghese, Attia Samy
Feline Coronavirus (FCoV) is a worldwide viral infection of felids. The disease is usually asymptomatic, but it can cause mild diarrhoea; however, few numbers of cases may develop a severe systemic disease known as feline infectious peritonitis (FIP). This study aims to determine the prevalence of FCoV shedding in the faeces of stray cats in Kuwait and detect antibodies against FCoV in their serum. Histopathological analyses and RT‑PCR were used to prove cases of FIP. A total of 178 cats were examined for the presence of FCoV in their faeces using a rapid immunochromatography (IC) test...
July 31, 2023: Veterinaria Italiana
https://read.qxmd.com/read/38324994/unlicensed-antiviral-products-used-for-the-at-home-treatment-of-feline-infectious-peritonitis-contain-gs-441524-at-significantly-different-amounts-than-advertised
#5
JOURNAL ARTICLE
Alycia M Kent, Su Guan, Nicole Jacque, Wendy Novicoff, Samantha J M Evans
OBJECTIVE: To analyze the content of unlicensed GS-441524-like products being used as a largely successful at-home treatment for cats suspected to have FIP. The remdesivir content and pH were also measured. SAMPLE: 127 injectable and oral samples from 30 of the most popular brands of black market producers. METHODS: Unlicensed GS-441524-like products were procured through donations and tested for GS-441524 and remdesivir content by liquid chromatography with tandem mass spectrometry...
February 7, 2024: Journal of the American Veterinary Medical Association
https://read.qxmd.com/read/38311297/an-adenovirus-vectored-vaccine-based-on-the-n-protein-of-feline-coronavirus-elicit-robust-protective-immune-responses
#6
JOURNAL ARTICLE
Yuanhong Wang, Yun Liu, Junna Wang, Miao Zhang, Xiaoying Deng, Junhan Song, Jie Zhu, Lingxue Yu, Guoxin Li, Guangqing Liu
Feline coronavirus (FCoV) is an unsegmented, single-stranded RNA virus belonging to the Alphacoronavirus genus. It can cause fatal feline infectious peritonitis (FIP) in cats of any ages. Currently, there are no effective prevention and control measures to against FCoV. In this study, we developed a recombinant adenovirus vaccine, AD5-N, based on the nucleocapsid(N) protein of FCoV. The immunogenicity of AD5-N was evaluated through intramuscular immunization in 6-week-old Balb/c mice and 9-12 months old cats...
February 2, 2024: Antiviral Research
https://read.qxmd.com/read/38291072/assessing-the-feasibility-of-applying-machine-learning-to-diagnosing-non-effusive-feline-infectious-peritonitis
#7
JOURNAL ARTICLE
Dawn Dunbar, Simon A Babayan, Sarah Krumrie, Hayley Haining, Margaret J Hosie, William Weir
Feline infectious peritonitis (FIP) is a severe feline coronavirus-associated syndrome in cats, which is invariably fatal without anti-viral treatment. In the majority of non-effusive FIP cases encountered in practice, confirmatory diagnostic testing is not undertaken and reliance is given to the interpretation of valuable, but essentially non-specific, clinical signs and laboratory markers. We hypothesised that it may be feasible to develop a machine learning (ML) approach which may be applied to the analysis of clinical data to aid in the diagnosis of disease...
January 30, 2024: Scientific Reports
https://read.qxmd.com/read/38288972/assessing-in-vitro-stability-of-remdesivir-gs-5734-and-conversion-to-gs-441524-in-feline-plasma-and-whole-blood
#8
JOURNAL ARTICLE
Sally J Coggins, Benjamin Kimble, Richard Malik, Mary F Thompson, Jacqueline M Norris, Merran Govendir
Feline infectious peritonitis (FIP) is a potentially fatal coronavirus-driven disease of cats. Treatment with nucleoside analogue GS-441524 and or prodrug remdesivir (RDV) have produced remission in both experimentally induced and naturally occurring FIP, yet information regarding metabolism of RDV into GS-441524 in cats is scarce. This study assessed possible phase I metabolism of RDV in cats, utilising an in vitro  feline microsome model with in vitro t1/2 and  in vitro  Clint  calculated using the substrate depletion method...
December 2024: Veterinary Quarterly
https://read.qxmd.com/read/38271816/quality-assessment-and-characterization-of-unregulated-antiviral-drugs-for-feline-infectious-peritonitis-implications-for-treatment-safety-and-efficacy
#9
JOURNAL ARTICLE
Aidan J Mulligan, Megan E Browning
OBJECTIVE: Feline infectious peritonitis is fatal, and due to lack of approved treatments, unregulated antiviral drugs are used to treat this disease. This study set out to determine the purity of various batches of these drugs from several companies, characterize them, and note any impurities or other unusual characteristics. We also developed a method to qualitatively assess the primary components before administration. SAMPLES: We tested 30 vials from 17 brands of GS-441524 and 5 vials from 1 brand of GC376...
January 29, 2024: American Journal of Veterinary Research
https://read.qxmd.com/read/38257841/an-aptamer-based-proteomic-analysis-of-plasma-from-cats-felis-catus-with-clinical-feline-infectious-peritonitis
#10
JOURNAL ARTICLE
Benjamin E Curtis, Zaid Abdo, Barbara Graham, Alora LaVoy, Samantha J M Evans, Kelly Santangelo, Gregg A Dean
Feline infectious peritonitis (FIP) is a systemic disease manifestation of feline coronavirus (FCoV) and is the most important cause of infectious disease-related deaths in domestic cats. FIP has a variable clinical manifestation but is most often characterized by widespread vasculitis with visceral involvement and/or neurological disease that is typically fatal in the absence of antiviral therapy. Using an aptamer-based proteomics assay, we analyzed the plasma protein profiles of cats who were naturally infected with FIP (n = 19) in comparison to the plasma protein profiles of cats who were clinically healthy and negative for FCoV (n = 17) and cats who were positive for the enteric form of FCoV (n = 9)...
January 18, 2024: Viruses
https://read.qxmd.com/read/38236006/an-rna-replicon-system-to-investigate-promising-inhibitors-of-feline-coronavirus
#11
JOURNAL ARTICLE
Kimberly Schmied, Rosina Ehmann, Claudia Kristen-Burmann, Nadine Ebert, Güliz Tuba Barut, Lea Almeida, Jenna N Kelly, Lisa Thomann, Hanspeter Stalder, Reto Lang, Gergely Tekes, Volker Thiel
FIPV is of great significance in the cat population around the world, causing 0.3%-1.4% of feline deaths in veterinary practices (2). As there are neither effective preventive measures nor approved treatment options available, there is an urgent need to identify antiviral drugs against FIPV. Our FCoV replicon system provides a valuable tool for drug discovery in vitro . Due to the lack of cell culture systems for serotype I FCoVs (the serotype most prevalent in the feline population) (2), a different system is needed to study these viruses...
January 18, 2024: Journal of Virology
https://read.qxmd.com/read/38176470/feline-infectious-peritonitis-virus-orf7a-is-a-virulence-factor-involved-in-inflammatory-pathology-in-cats
#12
JOURNAL ARTICLE
Zhe Jiao, Pengpeng Wang, Xiaoshuai Hu, Yixi Chen, Juan Xu, Jintao Zhang, Benyuan Wu, Ruxue Luo, Yuejun Shi, Guiqing Peng
A hyperinflammatory response is a prominent feature of feline infectious peritonitis (FIP), but the mechanisms behind the feline infectious peritonitis virus (FIPV)-induced cytokine storm in the host have not been clarified. Studies have shown that coronaviruses encode accessory proteins that are involved in viral replication and associated with viral virulence, the inflammatory response and immune regulation. Here, we found that FIPV ORF7a gene plays a key role in viral infection and host proinflammatory responses...
January 2, 2024: Antiviral Research
https://read.qxmd.com/read/38095890/abdominal-ultrasonographic-findings-of-cats-with-feline-infectious-peritonitis-an-update
#13
JOURNAL ARTICLE
Thiago R Müller, Dominique G Penninck, Cynthia Rl Webster, Francisco O Conrado
OBJECTIVES: The aim of this study was to describe the abdominal ultrasonographic findings in cats with confirmed or presumed feline infectious peritonitis (FIP). METHODS: This was a retrospective study performed in an academic veterinary hospital. The diagnosis of FIP was reached on review of history, signalment, clinical presentation, complete blood count, biochemistry panel, peritoneal fluid analysis, cytology and/or histopathology results from abnormal organs, and/or molecular testing (immunohistochemical or FIP coronavirus [FCoV] RT-PCR)...
December 2023: Journal of Feline Medicine and Surgery
https://read.qxmd.com/read/38032049/uroliths-composed-of-antiviral-compound-gs-441524-in-2-cats-undergoing-treatment-for-feline-infectious-peritonitis
#14
Marissa Allinder, Beth Tynan, Cara Martin, Amelia Furbish, Glenn Austin, Joe Bartges, Bianca N Lourenço
Feline infectious peritonitis (FIP) historically has been a fatal disease in cats. Recent unlicensed use of antiviral medication has been shown to markedly improve survival of this infection. An 8-month-old female spayed domestic short-haired cat undergoing treatment for presumptive FIP with the antiviral nucleoside analog GS-441524 developed acute progressive azotemia. Abdominal ultrasound examination identified multifocal urolithiasis including renal, ureteral, and cystic calculi. Unilateral ureteral obstruction progressed to suspected bilateral ureteral obstruction and subcutaneous ureteral bypass (SUB) was performed along with urolith removal and submission for analysis...
November 30, 2023: Journal of Veterinary Internal Medicine
https://read.qxmd.com/read/38028839/comparison-of-the-performance-of-bioresonance-electrophoresis-and-rt-pcr-in-the-diagnosis-of-feline-infectious-peritonitis
#15
JOURNAL ARTICLE
F Farsijani, S Safi, S H Shirazi Beheshtiha
Feline infectious peritonitis (FIP) continues to be one of the most researched infectious diseases of cats. The diagnosis of FIP is challenging, and diverse techniques have been developed for its accurate diagnosis. However, they have some limitations. The present study was conducted to investigate the efficacy of specific modulation frequency (SMF), compared to other routine diagnostic methods for detecting feline coronavirus . Blood samples were collected from 30 diseased cats suspected of having FIP based on clinical signs...
June 2023: Archives of Razi Institute
https://read.qxmd.com/read/38023430/dynamics-of-feline-coronavirus-and-fip-a-compartmental-modeling-approach
#16
JOURNAL ARTICLE
Ayse Peker Dobie, Alper Bayrakal, Mehmet Erman Or, Ayse Humeyra Bilge
The investigation of infectious agents invading human and nonhuman populations represents a rich research domain within the framework of mathematical biology, captivating the interest of scientists across various disciplines. In this work, we examine the endemic equilibrium of feline coronavirus and feline infectious peritonitis by using a modified susceptible-infected-susceptible epidemiological model. We incorporate the concept of mutations from FCoV to FIP to enrich our analysis. We establish that the model, when subjected to reasonable parameter ranges, supports an endemic equilibrium wherein the FCoV group dominates...
2023: Veterinary Medicine International
https://read.qxmd.com/read/38016285/bilateral-ocular-opacification-and-weight-loss-in-a-cat
#17
JOURNAL ARTICLE
Alexa A Crise, Ryan Taylor, Kelli L Zimmerman
No abstract text is available yet for this article.
December 1, 2023: Journal of the American Veterinary Medical Association
https://read.qxmd.com/read/37975439/fcov-23-causing-fip-in-a-cat-imported-to-the-uk-from-cyprus
#18
JOURNAL ARTICLE
Amanda Warr, Charalampos Attipa, Danielle Gunn-Moore, Christine Tait-Burkard
No abstract text is available yet for this article.
November 18, 2023: Veterinary Record
https://read.qxmd.com/read/37956666/-options-for-treatment-of-feline-infectious-peritonitis-previously-and-today
#19
JOURNAL ARTICLE
Daniela Krentz, Michèle Bergmann, Sandra Felten, Katrin Hartmann
Feline infectious peritonitis (FIP) is one of the most common infectious diseases in cats that is fatal when untreated. So far, there is no legally available effective treatment in Germany. Treatment options include only symptomatic treatment (e. g. glucocorticoids, propentofylline), immunomodulatory approaches (e. g. interferons, polyprenyl immunostimulant), and antiviral chemotherapy with protease inhibitors (e. g. GC376) or nucleoside analogues (e. g. GS-441524, remdesivir). Symptomatic treatment does not cure FIP but may lead to a short-term improvement of clinical signs in a subset of cats...
October 2023: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://read.qxmd.com/read/37939649/analysis-of-spike-and-accessory-3c-genes-mutations-of-less-virulent-and-fip-associated-feline-coronaviruses-in-beijing-china
#20
JOURNAL ARTICLE
Jingru Zhu, Shuqi Deng, Danxia Mou, Gege Zhang, Yingying Fu, Wei Huang, Yueping Zhang, Yanli Lyu
Mutations in S and 3c genes of feline coronavirus (FCoV) have been associated with the development of feline infectious peritonitis (FIP). In the present study, FCoV S and 3c genes mutations were analyzed in healthy and FIP cats. M1058L mutation was found in 13.64% (3/22) feces from FIP cats, but not in feces from healthy cats (0/39). The intact 3c gene was found in feces from both healthy cats (19/19) and FIP cats (12/12). All parenteral samples from FIP cats carried one or more of the M1058L mutation, S1060A mutation and mutated 3c gene...
October 30, 2023: Virology
keyword
keyword
58832
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.