Read by QxMD icon Read

Sox11 neuron

Bhavana Muralidharan, Zeba Khatri, Upasana Maheshwari, Ritika Gupta, Basabdatta Roy, Saurabh J Pradhan, Krishanpal Karmodiya, Hari Padmanabhan, Ashwin Shetty, Chinthapalli Balaji, Ullas Kolthur-Seetharam, Jeffrey D Macklis, Sanjeev Galande, Shubha Tole
: In the developing cerebral cortex, sequential transcriptional programs take neuroepithelial cells from proliferating progenitors to differentiated neurons with unique molecular identities. The regulatory changes that occur in the chromatin of the progenitors are not well understood. During deep layer neurogenesis, we show that transcription factor Lhx2 binds to distal regulatory elements of Fezf2 and Sox11, critical determinants of neuron subtype identity in the mouse neocortex. We demonstrate that Lhx2 binds to the NuRD histone remodeling complex subunits LSD1, HDAC2, and RBBP4, which are proximal regulators of the epigenetic state of chromatin...
December 1, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Naveen Jayaprakash, Zimei Wang, Brian Hoeynck, Nicholas Krueger, Audra Kramer, Eric Balle, Daniel S Wheeler, Robert A Wheeler, Murray G Blackmore
UNLABELLED: To restore function after injury to the CNS, axons must be stimulated to extend into denervated territory and, critically, must form functional synapses with appropriate targets. We showed previously that forced overexpression of the transcription factor Sox11 increases axon growth by corticospinal tract (CST) neurons after spinal injury. However, behavioral outcomes were not improved, raising the question of whether the newly sprouted axons are able to form functional synapses...
May 25, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Yoshio Hoshiba, Tomohisa Toda, Haruka Ebisu, Mayu Wakimoto, Shigeru Yanagi, Hiroshi Kawasaki
UNLABELLED: The coordinated mechanisms balancing promotion and suppression of dendritic morphogenesis are crucial for the development of the cerebral cortex. Although previous studies have revealed important transcription factors that promote dendritic morphogenesis during development, those that suppress dendritic morphogenesis are still largely unknown. Here we found that the expression levels of the transcription factor Sox11 decreased dramatically during dendritic morphogenesis. Our loss- and gain-of-function studies using postnatal electroporation and in utero electroporation indicate that Sox11 is necessary and sufficient for inhibiting dendritic morphogenesis of excitatory neurons in the mouse cerebral cortex during development...
May 25, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Javier Del Pino Sans, Kelsey J Clements, Alexander Suvorov, Sudha Krishnan, Hillary L Adams, Sandra L Petersen
Developmental exposure to arylhydrocarbon receptor (AhR) ligands abolishes sex differences in a wide range of neural structures and functions. A well-studied example is the anteroventral periventricular nucleus (AVPV), a structure that controls sex-specific luteinizing hormone (LH) release. In the male, testosterone (T) secreted by the developing testes defeminizes LH release mechanisms; conversely, perinatal AhR activation by 2,3,7,8,-tetrachlorodibenzo-p-dioxin (TCDD) blocks defeminization. To better understand developmental mechanisms altered by TCDD exposure, we first verified that neonatal TCDD exposure in male rats prevented the loss of AVPV GABA/glutamate neurons that are critical for female-typical LH surge release...
August 4, 2016: Neuroscience
Chao Chen, Jing Jin, Garrett A Lee, Elena Silva, Maria Donoghue
A well-functioning brain requires production of the correct number and types of cells during development; cascades of transcription factors are essential for cellular coordination. Sox proteins are transcription factors that affect various processes in the development of the nervous system. Sox11, a member of the SoxC family, is expressed in differentiated neurons and supports neuronal differentiation in several systems. To understand how generalizable the actions of Sox11 are across phylogeny, its function in the development of the frog nervous system and the mouse cerebral cortex were compared...
2016: Biology Open
Milica Putnik, David Brodin, Tomasz K Wojdacz, Fredrik Fagerström-Billai, Karin Dahlman-Wright, Annika E Wallberg
Mastermind-like 1 (MAML1) is a transcriptional coregulator that has been associated with early development of many systems such as neuronal, muscular and urogenital. The present study aimed to explore the genome wide effects of MAML1 on DNA methylation and RNA expression in human embryonic kidney cells. Infinium HumanMethylation450 BeadChip Illumina array, methylation-sensitive high-resolution melt technique, Chip Analysis Methylation Pipeline and RNA profiling approaches were used to study MAML1 effects on the epigenome...
March 2016: Molecular Biology Reports
Chao Chen, Garrett A Lee, Ariel Pourmorady, Elisabeth Sock, Maria J Donoghue
As the cerebral cortex forms, specialized molecular cascades direct the expansion of progenitor pools, the differentiation of neurons, or the maturation of discrete neuronal subtypes, together ensuring that the correct amounts and classes of neurons are generated. In several neural systems, the SoxC transcriptional regulators, particularly Sox11 and Sox4, have been characterized as functioning exclusively and redundantly in promoting neuronal differentiation. Using the mouse cerebral cortex as a model, Sox11 and Sox4 were examined in the formation of the most complex part of the mammalian brain...
July 22, 2015: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Nicholas M Kanaan, Timothy J Collier, Allyson Cole-Strauss, Tessa Grabinski, Zachary R Mattingly, Mary E Winn, Kathy Steece-Collier, Caryl E Sortwell, Fredric P Manfredsson, Jack W Lipton
We hypothesized that the study of gene expression at 1, 2, 4, 6 and 16 weeks in the substantia nigra (SN) after intrastriatal 6-OHDA in the Sprague-Dawley rat (rattus norvegicus) would identify cellular responses during the degenerative process that could be axoprotective. Specifically, we hypothesized that genes expressed within the SN that followed a profile of being highly upregulated early after the lesion (during active axonal degeneration) and then progressively declined to baseline over 16 weeks as DA neurons died are indicative of potential protective responses to the striatal 6-OHDA insult...
2015: PloS One
Sierk Haenisch, Yi Zhao, Aparna Chhibber, Kitti Kaiboriboon, Lynn V Do, Silke Vogelgesang, Nicholas M Barbaro, Brian K Alldredge, Daniel H Lowenstein, Ingolf Cascorbi, Deanna L Kroetz
MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally control the expression of their target genes via RNA interference. There is increasing evidence that expression of miRNAs is dysregulated in neuronal disorders, including epilepsy, a chronic neurological disorder characterized by spontaneous recurrent seizures. Mesial temporal lobe epilepsy (MTLE) is a common type of focal epilepsy in which disease-induced abnormalities of hippocampal neurogenesis in the subgranular zone as well as gliosis and neuronal cell loss in the cornu ammonis area are reported...
May 2015: Neurobiology of Disease
Zimei Wang, Ashley Reynolds, Adam Kirry, Christopher Nienhaus, Murray G Blackmore
Embryonic neurons, peripheral neurons, and CNS neurons in zebrafish respond to axon injury by initiating pro-regenerative transcriptional programs that enable axons to extend, locate appropriate targets, and ultimately contribute to behavioral recovery. In contrast, many long-distance projection neurons in the adult mammalian CNS, notably corticospinal tract (CST) neurons, display a much lower regenerative capacity. To promote CNS repair, a long-standing goal has been to activate pro-regenerative mechanisms that are normally missing from injured CNS neurons...
February 18, 2015: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Z Su, T Zang, M-L Liu, L-L Wang, W Niu, C-L Zhang
Malignant gliomas, the most common solid tumors in the central nervous system, are essentially incurable due to their rapid growth and very invasive nature. One potential approach to eradicating glioma cells is to force these cells to undergo terminal differentiation and, in the process, to irreversible postmitotic arrest. Here, we show that neurogenin 2 (NGN2, also known as NEUROG2) synergizes with sex-determining region Y-box 11 (SOX11) to very efficiently convert human glioma cells to terminally differentiated neuron-like cells in both cell culture and adult mouse brains...
2014: Cell Death & Disease
Yuko Kuwae, Anna Kakehashi, Kenichi Wakasa, Min Wei, Shotaro Yamano, Naomi Ishii, Masahiko Ohsawa, Hideki Wanibuchi
OBJECTIVE: The present study aimed to identify novel useful clinical biomarker at early stages and to elucidate the molecular background of carcinogenesis in human pancreatic ductal adenocarcinomas (PDACs). METHODS: Proteomes of dissected PDACs and adjacent nontumor pancreatic tissues from formalin-fixed and paraffin-embedded sections from 10 patients were analyzed using QSTAR Elite liquid chromatography-tandem mass spectrometry, ProteinPilot Software, and Ingenuity Pathway Analysis...
January 2015: Pancreas
Mamta Pamnani, Puja Sinha, Seema Nara, Manisha Sachan
Sox11, a member of the group C Sox transcription factor family, is predominantly expressed in the neurogenic areas of the adult brain. In the embryo, Sox11 is expressed in the developing nervous system in both glial and neuronal lineages. Its expression exhibits a dynamic pattern with respect to both expression sites and expression levels. The aim of the present study is to investigate the role of de novo methylation in regulation of its tissue specific expression. The dynamics of de novo methylation of 24 CpGs is studied with the help of sodium bisulfite genomic DNA sequencing in the mouse brain, kidney and testis at different developmental stages i...
November 15, 2014: Gene
Yuji Guo, Shangming Liu, Xianghong Zhang, Liyan Wang, Xiaoli Zhang, Aijun Hao, Aiqing Han, Jie Yang
We introduced a lentiviral vector containing the Sox11 gene into injured spinal cords of mice to evaluate the therapeutic potential of Sox11 in spinal cord injury. Sox11 markedly improved locomotor recovery after spinal cord injury and this recovery was accompanied by an up-regulation of Nestin/Doublecortin expression in the injured spinal cord. Sox11 was mainly located in endogenous neural stem cells lining the central canal and in newly-generated neurons in the spinal cord. In addition, Sox 11 significantly induced expressions of BDNF in the spinal cords of LV-Sox11-treated mice...
April 18, 2014: Biochemical and Biophysical Research Communications
Kohei Yamamizu, Yulan Piao, Alexei A Sharov, Veronika Zsiros, Hong Yu, Kazu Nakazawa, David Schlessinger, Minoru S H Ko
A network of transcription factors (TFs) determines cell identity, but identity can be altered by overexpressing a combination of TFs. However, choosing and verifying combinations of TFs for specific cell differentiation have been daunting due to the large number of possible combinations of ∼2,000 TFs. Here, we report the identification of individual TFs for lineage-specific cell differentiation based on the correlation matrix of global gene expression profiles. The overexpression of identified TFs-Myod1, Mef2c, Esx1, Foxa1, Hnf4a, Gata2, Gata3, Myc, Elf5, Irf2, Elf1, Sfpi1, Ets1, Smad7, Nr2f1, Sox11, Dmrt1, Sox9, Foxg1, Sox2, or Ascl1-can direct efficient, specific, and rapid differentiation into myocytes, hepatocytes, blood cells, and neurons...
2013: Stem Cell Reports
Jeremy A Miller, Jason Nathanson, Daniel Franjic, Sungbo Shim, Rachel A Dalley, Sheila Shapouri, Kimberly A Smith, Susan M Sunkin, Amy Bernard, Jeffrey L Bennett, Chang-Kyu Lee, Michael J Hawrylycz, Allan R Jones, David G Amaral, Nenad Šestan, Fred H Gage, Ed S Lein
The neurogenic potential of the subgranular zone (SGZ) of the hippocampal dentate gyrus is likely to be regulated by molecular cues arising from its complex heterogeneous cellular environment. Through transcriptome analysis using laser microdissection coupled with DNA microarrays, in combination with analysis of genome-wide in situ hybridization data, we identified 363 genes selectively enriched in adult mouse SGZ. These genes reflect expression in the different constituent cell types, including progenitor and dividing cells, immature granule cells, astrocytes, oligodendrocytes and GABAergic interneurons...
November 2013: Development
Jovica Ninkovic, Andrea Steiner-Mezzadri, Melanie Jawerka, Umut Akinci, Giacomo Masserdotti, Stefania Petricca, Judith Fischer, Alexander von Holst, Johanes Beckers, Chichung D Lie, David Petrik, Erik Miller, Jiong Tang, Jiang Wu, Veronique Lefebvre, Jeroen Demmers, Amelia Eisch, Daniel Metzger, Gerald Crabtree, Martin Irmler, Raymond Poot, Magdalena Götz
Numerous transcriptional regulators of neurogenesis have been identified in the developing and adult brain, but how neurogenic fate is programmed at the epigenetic level remains poorly defined. Here, we report that the transcription factor Pax6 directly interacts with the Brg1-containing BAF complex in adult neural progenitors. Deletion of either Brg1 or Pax6 in the subependymal zone (SEZ) causes the progeny of adult neural stem cells to convert to the ependymal lineage within the SEZ while migrating neuroblasts convert to different glial lineages en route to or in the olfactory bulb (OB)...
October 3, 2013: Cell Stem Cell
Meng-Lu Liu, Tong Zang, Yuhua Zou, Joshua C Chang, Jay R Gibson, Kimberly M Huber, Chun-Li Zhang
Cell fate can be reprogrammed by modifying intrinsic and extrinsic cues. Here we show that two small molecules (forskolin and dorsomorphin) enable the transcription factor Neurogenin 2 (NGN2) to convert human fetal lung fibroblasts into cholinergic neurons with high purity (>90%) and efficiency (up to 99% of NGN2-expressing cells). The conversion is direct without passing through a proliferative progenitor state. These human induced cholinergic neurons (hiCN) show mature electrophysiological properties and exhibit motor neuron-like features, including morphology, gene expression and the formation of functional neuromuscular junctions...
2013: Nature Communications
Weijun Feng, Muhammad Amir Khan, Pablo Bellvis, Zhe Zhu, Olga Bernhardt, Christel Herold-Mende, Hai-Kun Liu
Chromatin factors that regulate neurogenesis in the central nervous system remain to be explored. Here, we demonstrate that the chromatin remodeler chromodomain-helicase-DNA-binding protein 7 (CHD7), a protein frequently mutated in human CHARGE syndrome, is a master regulator of neurogenesis in mammalian brain. CHD7 is selectively expressed in actively dividing neural stem cells (NSCs) and progenitors. Genetic inactivation of CHD7 in NSCs leads to a reduction of neuronal differentiation and aberrant dendritic development of newborn neurons...
July 3, 2013: Cell Stem Cell
Jez Huang, Michel Arsenault, Martin Kann, Carlos Lopez-Mendez, Monique Saleh, Dorota Wadowska, Mary Taglienti, Jacqueline Ho, Yuan Miao, David Sims, Jonathan Spears, Alfonso Lopez, Glenda Wright, Sunny Hartwig
BACKGROUND: The DNA-binding transcription factor Wilms' Tumor Suppressor-1 (WT1) plays an essential role in nephron progenitor differentiation during renal development. We previously used Wt1 chromatin-immunoprecipitation coupled to microarray (ChIP-chip) to identify novel Wt1 target genes that may regulate nephrogenesis in vivo. We discovered that all three members of the SoxC subfamily, namely, Sox4, Sox11, and Sox12, are bound by Wt1 in mouse embryonic kidneys in vivo. SoxC genes play master roles in determining neuronal and mesenchymal progenitor cell fate in a multitude of developmental processes, but their function in the developing kidney is largely unknown...
June 2013: Developmental Dynamics: An Official Publication of the American Association of Anatomists
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"