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https://www.readbyqxmd.com/read/28328663/sepsis-and-multi-organ-failure
#1
Kevin K Chung
No abstract text is available yet for this article.
March 15, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28323232/suspected-giant-cell-aortitis-from-multiple-aortic-structural-damage-to-fatal-listeria-sepsi-a-case-report
#2
Valeria Silvestri, Giacomo Isernia
Giant cell arteritis ( GCA) is an inflammatory vasculopathy affecting large and middle-sized vessels , specifically cranial arteries derived from carotid artery. Isolated extracranial vessel involvement can occur. Interest in extravascular manifestations is recently increasing because of diffusion of sensitive and specific imaging tools such as 18FDG PET TC . Patients have an increased relative risk of severe infection. Listeria monocytogenes infection risk is increased, and vascular system involvement and graft infection have been, even though rarely, reported...
March 16, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28323121/the-treatment-of-intermediate-stage-tumour-beyond-tace-from-surgery-to-systemic-therapy
#3
REVIEW
Peter R Galle, Francesco Tovoli, Friedrich Foerster, Marcus A Wörns, Alessandro Cucchetti, Luigi Bolondi
Intermediate stage hepatocellular carcinoma (HCC) comprises the largest subgroup of patients with this disease and is characterized by substantial heterogeneity. Functional liver impairment, total tumour burden and other prognostic factors such as high alpha-fetoprotein serum level, presence of micro-vascular invasion, and poorly differentiated tumours relevantly contribute to outcome. The usage of the standard therapeutic approach, transarterial chemoembolization - TACE, for all intermediate stage HCC patients is probably an over-simplification and may therefore not be appropriate for all patients...
March 17, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28303073/acute-kidney-injury-definition-pathophysiology-and-clinical-phenotypes
#4
REVIEW
Konstantinos Makris, Loukia Spanou
Acute kidney injury (AKI) is a clinical syndrome that complicates the course and worsens the outcome in a significant number of hospitalised patients. Recent advances in clinical and basic research will help with a more accurate definition of this syndrome and in the elucidation of its pathogenesis. With this knowledge we will be able to conduct more accurate epidemiologic studies in an effort to gain a better understanding of the impact of this syndrome. AKI is a syndrome that rarely has a sole and distinct pathophysiology...
May 2016: Clinical Biochemist. Reviews
https://www.readbyqxmd.com/read/28299558/body-pushing-prescription-drugs-and-hospital-admission
#5
Roger W Byard, Michaela Kenneally
A 39-year-old man died of multi-organ failure complicating mixed drug toxicity that included methadone, oxazepam, oxycodone and nitrazepam. His past medical history involved alcohol and poly-substance abuse with chronic self-harm and suicidal ideation. There had been multiple hospital admissions for drug overdoses. At autopsy the most unusual finding was of two packages of 10 tablets each, wrapped in thin plastic film within the rectum. The insertion of drugs into body orifices and cavities has been termed body pushing to distinguish it from body packing where illicit drugs are wrapped and swallowed for transport and smuggling, and body stuffing where small amounts of loosely wrapped or unwrapped drugs are swallowed to conceal evidence from police...
March 15, 2017: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/28297072/operational-failures-detected-by-frontline-acute-care-nurses
#6
Kathleen R Stevens, Eileen P Engh, Heather Tubbs-Cooley, Deborah Marks Conley, Tammy Cupit, Ellen D'Errico, Pam DiNapoli, Joleen Lynn Fischer, Ruth Freed, Anne Marie Kotzer, Carolyn L Lindgren, Marie Ann Marino, Lisa Mestas, Jessica Perdue, Rebekah Powers, Patricia Radovich, Karen Rice, Linda P Riley, Peri Rosenfeld, Linda Roussel, Nancy A Ryan-Wenger, Linda Searle-Leach, Nicole M Shonka, Vicki L Smith, Laura Sweatt, Mary Townsend-Gervis, Ellen Wathen, Janice S Withycombe
Frontline nurses encounter operational failures (OFs), or breakdowns in system processes, that hinder care, erode quality, and threaten patient safety. Previous research has relied on external observers to identify OFs; nurses have been passive participants in the identification of system failures that impede their ability to deliver safe and effective care. To better understand frontline nurses' direct experiences with OFs in hospitals, we conducted a multi-site study within a national research network to describe the rate and categories of OFs detected by nurses as they provided direct patient care...
March 15, 2017: Research in Nursing & Health
https://www.readbyqxmd.com/read/28295441/fosfomycin-for-the-treatment-of-cystitis-in-the-abdominal-solid-organ-transplant-population
#7
A A Loethen, L Kerstenetzky, J L Descourouez, G E Leverson, J A Smith, M R Jorgenson
STUDY OBJECTIVES: Evaluate the use of fosfomycin (FOS) at the FDA-approved single-dose regimen as well as off-label multidose regimens for the treatment of cystitis after abdominal solid organ transplant (aSOT). DESIGN: Retrospective study. SETTING: Tertiary academic medical center. PATIENTS: Adult inpatients with history of aSOT receiving FOS between 1/1/2009-4/30/2015 for the treatment of cystitis. MEASUREMENTS AND MAIN RESULTS: Seventy-six courses of FOS were identified in 64 patients...
March 12, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28294674/-necrotizing-fasciitis-in-head-and-neck-area
#8
Beáta Sántha, Katalin Sári, Zoltán Fülep, Márta Patyi, Ferenc Oberna
Necrotizing fasciitis is a fulminant infection of the deeper layers of skin and subcutaneous tissues characterized by progressive soft tissue necrosis and high mortality. It rarely occurs in the head and neck area. The clinical picture includes non-specific but typical local and systemic symptoms. The treatment is a complex, multidisciplinary task which includes radical surgical exploration, debridement and drainage, empirically started and then targeted intravenous antibiotics and supportive therapy. Authors report a case of necrotizing fasciitis localized on the right side of the face which caused multi-organ failure and phlegmone of the neck...
March 2017: Magyar Sebészet
https://www.readbyqxmd.com/read/28294401/endothelial-progenitor-cell-mobilization-in-preterm-infants-with-sepsis-is-associated-with-improved-survival
#9
Vahid Siavashi, Simin Asadian, Masoud Taheri-Asl, Samaneh Keshavarz, Mohamad Zamani-Ahmadmahmudi, Seyed Mahdi Nassiri
Microvascular dysfunction plays a key role in the pathology of sepsis, leading to multi-organ failure and death. Circulating endothelial progenitor cells (cEPCs) are critically involved in the maintenance of the vascular homeostasis in both physiological and pathological contexts. In this study, concentration of cEPCs in preterm infants with sepsis was determined to recognize whether the EPC mobilization would affect the clinical outcome of infantile sepsis. 133 preterm infants (81 with sepsis and 52 without sepsis) were enrolled in this study...
March 10, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28293919/-extracorporeal-liver-support-of-liver-failure
#10
Hans Ulrich Gerth, Michele Pohlen, Hermann Pavenstädt, Hartmut Schmidt
Extracorporeal liver support can be classified into cell-free, artificial methods (artificial liver support, ALS) and cell-based bioartificial methods (bioartificial liver support, BLS). ALS improves biochemical parameters of liver failure by the simultaneous removal of protein-bound and water-soluble substances. Here, the MARS therapy belongs to the most studied methods with a proved beneficial effect on hepatic encephalopathy (HE), hepatorenal syndrome (HRS) or hyperbilirubinemia. However, a general survival advantage of any liver support for liver failure has not been shown yet and is restricted to meta-analyses or patient subgroups...
March 14, 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/28291705/serum-calcium-as-an-indicator-of-persistent-organ-failure-in-acute-pancreatitis
#11
Tao Peng, Xin Peng, Min Huang, Jing Cui, Yushun Zhang, Heshui Wu, Chunyou Wang
AIM: Decreased level of serum calcium was commonly seen in critical illness. Hypocalcemia was significantly more frequent in patients with severe form of acute pancreatitis (AP), and a negative correlation was observed between endotoxemia and serum calcium in AP. AP patients with persistent organ failure (POF) show an extremely high mortality. The association underlying calcium and POF in AP has not been characterized. METHODS: We conducted a retrospective cohort study of adult patients who presented within 72hours from symptom onset of AP at our center between January 2014 and May 2015...
February 4, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28285079/defibrotide-for-patients-with-hepatic-veno-occlusive-disease-sinusoidal-obstruction-syndrome-vod-sos-interim-results-from-a-treatment-ind-study
#12
Paul G Richardson, Angela R Smith, Brandon M Triplett, Nancy A Kernan, Stephan A Grupp, Joseph H Antin, Leslie Lehmann, Tsiporah Shore, Massimo Iacobelli, Maja Miloslavsky, Robin Hume, Alison L Hannah, Bijan Nejadnik, Robert J Soiffer
Hepatic veno-occlusive disease, or sinusoidal obstruction syndrome (VOD/SOS), is a serious and potentially fatal complication of conditioning for hematopoietic stem cell transplantation (HSCT) or of chemotherapy regimens alone. Defibrotide is a complex mixture of single-stranded polydeoxyribonucleotides that is approved in the United States for treatment of hepatic VOD/SOS with renal or pulmonary dysfunction post-HSCT and in the European Union, Israel, and South Korea for treatment of severe hepatic VOD/SOS post-HSCT...
March 8, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28283677/guillain-barr%C3%A3-syndrome-presenting-with-sinus-node-dysfunction-and-refractory-shock
#13
Le Dung Ha, Farrukh Abbas, Mohan Rao
BACKGROUND Guillain-Barré syndrome (GBS) is an acute inflammatory demyelinating polyneuropathy that is usually associated with preceding respiratory or gastrointestinal infection and has the hallmark manifestation of ascending flaccid paralysis. We report an atypical presentation of GBS. CASE REPORT A 76-year-old male presented with acute onset of diaphoresis and altered mental status. He subsequently developed severe bradycardia and refractory hypotension, which initially responded to dopamine infusion. A temporary pacemaker wire was placed to stabilize the heart rate but hypotension persisted...
March 11, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28275618/extracorporeal-life-support-for-refractory-ventricular-tachycardia
#14
REVIEW
Sujatha P Bhandary, Nicholas Joseph, James P Hofmann, Theodosios Saranteas, Thomas J Papadimos
Extracorporeal life support (ECLS) is a very effective bridging therapy in patients with refractory ventricular tachycardia (VT) associated with cardiogenic shock. A moribund patient in extremis, is not amenable to optimization by standard ACC/AHA guidelines. New approaches and novel salvage techniques are necessary to improve outcomes in patients with refractory clinical settings such as malignant ventricular arrhythmias, cardiac arrest, cardiogenic shock and/or pulmonary failure until further management options are explored...
February 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28275227/halogenated-volatile-anesthetics-in-the-intensive-care-unit-current-knowledge-on-an-upcoming-practice
#15
Pascal L Langlois, Frederick D'Aragon, William Manzanares
The aim of this narrative review was to highlight key points of volatile anesthetics administration in the intensive care unit (ICU), including AnaConDa® and Mirus® devices characteristics and the reported findings on clinical outcomes in critically ill patients. Intravenous sedation in the ICU is associated with issues, such as over- and under-sedation. Halogenated compounds, which can be safely administered by inserting a device in any ICU ventilation circuit, have interesting pharmacodynamic and pharmacokinetic profiles for patients with multi-organ failure...
March 8, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28272165/reduced-insulin-resistance-contributes-to-the-beneficial-effect-of-protein-tyrosine-phosphatase-1b-deletion-in-a-mouse-model-of-sepsis
#16
Eugénie Delile, Rémi Nevière, Pierre-Alain Thiébaut, Julie Maupoint, Paul Mulder, David Coquerel, Sylvanie Renet, Jennifer Rieusset, Vincent Richard, Fabienne Tamion
Hyperglycemia is a common feature of septic patients and has been associated with poor outcome and high mortality. In contrast, insulin has been shown to decrease mortality and to prevent the incidence of multi-organ failure but is often associated with deleterious hypoglycemia. Protein Tyrosine Phosphatase 1B (PTP1B) is a negative regulator of both insulin signaling and NO production, and has been shown to be an aggravating factor in septic shock. To evaluate the potential therapeutic effect of PTP1B blockade on glucose metabolism and insulin resistance in an experimental model of sepsis, we assessed the effect of PTP1B gene deletion in a cecal ligation and puncture (CLP) model of sepsis...
March 7, 2017: Shock
https://www.readbyqxmd.com/read/28271449/multi-marker-approach-using-procalcitonin-presepsin-galectin-3-and-soluble-suppression-of-tumorigenicity-2-for-the-prediction-of-mortality-in-sepsis
#17
Hanah Kim, Mina Hur, Hee-Won Moon, Yeo-Min Yun, Salvatore Di Somma
BACKGROUND: Biomarker could be objective and reliable tools to predict mortality in sepsis. We explored the prognostic utilities of emerging biomarkers in septic patients and questioned whether adding biomarkers to the clinical variables would improve the prediction of mortality in sepsis. METHODS: This retrospective study included 157 septic patients (112 patients with sepsis; 45 patients with septic shock). Procalcitonin (PCT), presepsin, galectin-3, and soluble suppression of tumorigenicity 2 (sST2) concentrations were analyzed in relation to the 30-day all-cause mortality...
December 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28269737/the-autodigestion-hypothesis-proteolytic-receptor-cleavage-in-rheological-and-cardiovascular-cell-dysfunction1
#18
Geert W Schmid-Schönbein
Transformation of circulating leukocytes from a dormant into an activated state with changing rheological properties leads to a major shift of their behavior in the microcirculation. Low levels of pseudopod formation or expression of adhesion molecules facilitate relatively free passage through microvessels while activated leukocytes with pseudopods and enhanced levels of adhesion membrane proteins become trapped in microvessels, attach to the endothelium and migrate into the tissue. The transformation of leukocytes into an activated state is seen in many diseases...
March 2, 2017: Biorheology
https://www.readbyqxmd.com/read/28266162/short-term-results-of-alcohol-septal-ablation-as-a-bail-out-strategy-to-treat-severe-left-ventricular-outflow-tract-obstruction-after-transcatheter-mitral-valve-replacement-in-patients-with-severe-mitral-annular-calcification
#19
Mayra Guerrero, Dee Dee Wang, Dominique Himbert, Marina Urena, Amit Pursnani, Georges Kaddissi, Vijay Iyer, Michael Salinger, Tarun Chakravarty, Adam Greenbaum, Raj Makkar, Alec Vahanian, Ted Feldman, William O'Neill
OBJECTIVES: To evaluate the outcomes of the early experience of percutaneous alcohol septal ablation in patients with severe left ventricular outflow tract (LVOT) obstruction post transcatheter mitral valve replacement (TMVR). BACKGROUND: Severe LVOT obstruction with hemodynamic compromise is a complication of TMVR associated with high mortality. Percutaneous alcohol septal ablation has recently been described as a therapeutic option in this setting. METHODS: Multicenter retrospective review of clinical outcomes of patients undergoing alcohol septal ablation to treat LVOT obstruction after TMVR for severe mitral stenosis with severe mitral annular calcification...
March 7, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28263058/suppression-of-thermally-induced-fullerene-aggregation-in-poly-fullerene-based-multi-acceptor-organic-solar-cells
#20
Simon A Dowland, Michael Salvador, Jose Dario Perea, Nicola Gasparini, Stefan Langner, Sambatra Rajoelson, Hasina Harimino Ramanitra, Benjamin D Lindner, Andres Osvet, Christoph J Brabec, Roger C Hiorns, Hans-Joachim Egelhaaf
A novel main-chain poly(fullerene) poly{(fullerene)-alt-[2,5-bis(octyloxy)terephthalaldehyde]} (PPC4) is investigated for its hypothesized superior morphological stability as an electron accepting material in organic photovoltaics relative to the widely used fullerene phenyl-C61-butyric acid methyl ester (PCBM). When mixed with poly(3-hexylthiophene-2,5-diyl) (P3HT) PPC4 affords low charge generation yields due to poor intermixing within the blend. The adoption of a multi-acceptor system, by introducing PCBM into the P3HT:poly(fullerene) blend, was found to lead to a threefold enhancement in charge generation, affording power conversion efficiencies very close to the prototypical P3HT:PCBM binary control...
March 6, 2017: ACS Applied Materials & Interfaces
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