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https://www.readbyqxmd.com/read/29506577/atherogenic-index-of-plasma-is-a-novel-and-better-biomarker-associated-with-obesity-a-population-based-cross-sectional-study-in-china
#1
Xiaowei Zhu, Lugang Yu, Hui Zhou, Qinhua Ma, Xiaohua Zhou, Ting Lei, Jiarong Hu, Wenxin Xu, Nengjun Yi, Shufeng Lei
BACKGROUND: Atherogenic index of plasma (AIP) has been reported to be associated with cardiovascular diseases. However no study has yet systematically evaluated the association between AIP and obesity and its advantage in obesity prediction compared with conventional lipid components. METHODS: A total of 6465 participants aged over 30 years were included in this study. Blood lipid components including triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were measured, and AIP was calculated as log10 (TG/HDL-C)...
March 5, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29225355/evolutionary-conservation-and-functional-divergence-of-the-lfk-gene-family-play-important-roles-in-the-photoperiodic-flowering-pathway-of-land-plants
#2
Ling Liu, Yuanqi Wu, Zhengqiao Liao, Jing Xiong, Fengkai Wu, Jie Xu, Hai Lan, Qiling Tang, Shufeng Zhou, Yaxi Liu, Yanli Lu
ZEITLUPE (ZTL), LOV KELCH PROTEIN 2 (LKP2), and FLAVIN-BINDING KELCH REPEAT F-BOX 1 (FKF1)-blue-light photoreceptors-play important roles in regulating the circadian clock and photoperiodic flowering pathway in plants. In this study, phylogenetic analysis revealed that the LOV (Light, Oxygen, or Voltage) and Kelch repeat-containing F-box (LFK) gene family can be classified into two clades, ZTL/LKP2 and FKF1, with clear differentiation between monocots and dicots within each clade. The LFK family genes underwent strong purifying selection; however, signatures of positive selection to adapt to local conditions still existed in 18 specific codons...
April 2018: Heredity
https://www.readbyqxmd.com/read/29221155/cd109-released-from-human-bone-marrow-mesenchymal-stem-cells-attenuates-tgf-%C3%AE-induced-epithelial-to-mesenchymal-transition-and-stemness-of-squamous-cell-carcinoma
#3
Shufeng Zhou, Renzo Cecere, Anie Philip
Although there is increasing evidence that human bone marrow mesenchymal stem cells (hBM-MSCs) play an important role in cancer progression, the underlying mechanisms are poorly understood. Transforming growth factor β (TGF-β) is an important pro-metastatic cytokine. We have previously shown that CD109, a glycosylphosphatidylinositol-anchored protein, is a TGF-β co-receptor and a strong inhibitor of TGF-β signalling. Moreover, CD109 can be released from the cell surface. In the current study, we examined whether hBM-MSCs regulate the malignant properties of squamous cell carcinoma cells, and whether CD109 plays a role in mediating the effect of hBM-MSCs on cancer cells...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29142225/comparative-genomic-analysis-of-esophageal-squamous-cell-carcinoma-between-asian-and-caucasian-patient-populations
#4
Jiaying Deng, Hu Chen, Daizhan Zhou, Junhua Zhang, Yun Chen, Qi Liu, Dashan Ai, Hanting Zhu, Li Chu, Wenjia Ren, Xiaofei Zhang, Yi Xia, Menghong Sun, Huiwen Zhang, Jun Li, Xinxin Peng, Liang Li, Leng Han, Hui Lin, Xiujun Cai, Jiaqing Xiang, Shufeng Chen, Yihua Sun, Yawei Zhang, Jie Zhang, Haiquan Chen, Shijian Zhang, Yi Zhao, Yun Liu, Han Liang, Kuaile Zhao
Esophageal squamous cell carcinoma is a major histological type of esophageal cancer, with distinct incidence and survival patterns among races. Although previous studies have characterized somatic mutations in this disease, a rigorous comparison between different patient populations has not been conducted. Here we sequence the samples of 316 Chinese patients, combine them with those from The Cancer Genome Atlas, and perform a comparative analysis between Asian and Caucasian patients. We find that mutated CSMD3 is associated with better prognosis in Asian patients...
November 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/29083407/exome-chip-meta-analysis-identifies-novel-loci-and-east-asian-specific-coding-variants-that-contribute-to-lipid-levels-and-coronary-artery-disease
#5
Xiangfeng Lu, Gina M Peloso, Dajiang J Liu, Ying Wu, He Zhang, Wei Zhou, Jun Li, Clara Sze-Man Tang, Rajkumar Dorajoo, Huaixing Li, Jirong Long, Xiuqing Guo, Ming Xu, Cassandra N Spracklen, Yang Chen, Xuezhen Liu, Yan Zhang, Chiea Chuen Khor, Jianjun Liu, Liang Sun, Laiyuan Wang, Yu-Tang Gao, Yao Hu, Kuai Yu, Yiqin Wang, Chloe Yu Yan Cheung, Feijie Wang, Jianfeng Huang, Qiao Fan, Qiuyin Cai, Shufeng Chen, Jinxiu Shi, Xueli Yang, Wanting Zhao, Wayne H-H Sheu, Stacey Shawn Cherny, Meian He, Alan B Feranil, Linda S Adair, Penny Gordon-Larsen, Shufa Du, Rohit Varma, Yii-Der Ida Chen, Xiao-Ou Shu, Karen Siu Ling Lam, Tien Yin Wong, Santhi K Ganesh, Zengnan Mo, Kristian Hveem, Lars G Fritsche, Jonas Bille Nielsen, Hung-Fat Tse, Yong Huo, Ching-Yu Cheng, Y Eugene Chen, Wei Zheng, E Shyong Tai, Wei Gao, Xu Lin, Wei Huang, Goncalo Abecasis, Sekar Kathiresan, Karen L Mohlke, Tangchun Wu, Pak Chung Sham, Dongfeng Gu, Cristen J Willer
Most genome-wide association studies have been of European individuals, even though most genetic variation in humans is seen only in non-European samples. To search for novel loci associated with blood lipid levels and clarify the mechanism of action at previously identified lipid loci, we used an exome array to examine protein-coding genetic variants in 47,532 East Asian individuals. We identified 255 variants at 41 loci that reached chip-wide significance, including 3 novel loci and 14 East Asian-specific coding variant associations...
December 2017: Nature Genetics
https://www.readbyqxmd.com/read/28861148/a-proteomics-based-investigation-on-the-anticancer-activity-of-alisertib-an-aurora-kinase-a-inhibitor-in-hepatocellular-carcinoma-hep3b-cells
#6
Qiaohua Zhu, Meihua Luo, Chengyu Zhou, Zhiwei Zhou, Zhixu He, Xinfa Yu, Shufeng Zhou
Targeted therapy may provide survival benefit for advanced hepatocellular carcinoma (HCC) and Aurora A kinase (AURKA) represents a feasible target in cancer treatment. The purpose of this study is to investigate the anticancer activity of alisertib (ALS) on Hep3B cells based on a proteomic study conducted with the stable-isotope labeling by amino acids in cell culture (SILAC). The proteomic response to ALS was obtained with SILAC-based proteomic study. Cell cycle distribution and apoptosis were assessed using flow cytometry and autophagy was determined using flow cytometry and confocal microscopy...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28759768/identification-for-the-capability-of-cd-tolerance-accumulation-and-translocation-of-96-sorghum-genotypes
#7
Weitao Jia, Fangfang Miao, Sulian Lv, Juanjuan Feng, Shufeng Zhou, Xuan Zhang, Duoliya Wang, Shizhong Li, Yinxin Li
Cadmium (Cd) pollution is a worldwide environmental problem which heavily threatens human health and food security. Sorghum, as one of the most promising energy crop, has been considered to be the source of high-quality feedstock for ethanol fuel. Ninety-six sorghum genotypes were investigated under hydroponic conditions to compare their capabilities of Cd-tolerance, accumulation and translocation for their potential in remediation of Cd contamination. Different genotypes varied largely in the tolerance to Cd stress with tolerance indexes ranked from 0...
November 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28565753/clinical-and-genomic-responses-to-ultra-short-course-chemotherapy-in-spinal-tuberculosis
#8
Ningkui Niu, Qian Wang, Jiandang Shi, Xu Zhang, Guangqi Geng, Shufeng Zhou, Chia Thach, Feng Cheng, Zili Wang
Traditional treatments for spinal tuberculosis (TB) involve chemotherapy and surgery. In the present study, it has been identified that chemotherapy lasting <6 months [ultra-short course chemotherapy (UCCT)], rather than the 6-18 months of the traditional regimen, is effective in sustaining TB clearance following complete surgical debridement. This current study aims to compare the changes in peripheral blood gene expression prior to and following UCCT, subsequent to complete debridement of spinal TB lesions...
May 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28463782/asymptomatic-polyvascular-disease-and-the-risks-of-cardiovascular-events-and-all-cause-death
#9
Qian Zhang, Anxin Wang, Shufeng Zhang, Na Li, Shengyun Chen, Yaqing Zhang, Yong Zhou, Shouling Wu, Xingquan Zhao
BACKGROUND AND AIMS: Atherosclerosis is a diffuse and systemic disease. We aimed to assess prevalence and outcome of extracoronary polyvascular disease (polyVD) in the asymptomatic Chinese community population. METHODS: A random sample of 5440 participants aged 40 years or older were enrolled in the Asymptomatic Polyvascular Abnormalities Community Study from 2010 to 2011. Intracranial artery stenosis, extracranial artery stenosis, and lower extremity artery disease were detected by transcranial Doppler and duplex sonography, and by calculating the ankle brachial index...
July 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28335655/the-therapeutic-potential-of-targeting-abc-transporters-to-combat-multi-drug-resistance
#10
REVIEW
Piyush Bugde, Riya Biswas, Fabrice Merien, Jun Lu, Dong-Xu Liu, Mingwei Chen, Shufeng Zhou, Yan Li
Most disseminated cancers remain fatal despite the availability of a variety of conventional and novel treatments including surgery, chemotherapy, radiotherapy, immunotherapy, and biologically targeted therapy. A major factor responsible for the failure of chemotherapy in the treatment of cancer is the development of multidrug resistance (MDR). The overexpression of various ABC transporters in cancer cells can efficiently remove the anticancer drug from the cell, thus causing the drug to lose its effect. Areas covered: In this review, we summarised the ongoing research related to the mechanism, function, and regulation of ABC transporters...
May 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28068409/reprogramming-malignant-cancer-cells-toward-a-benign-phenotype-following-exposure-to-human-embryonic-stem-cell-microenvironment
#11
Shufeng Zhou, Mohamed Abdouh, Vincenzo Arena, Manuel Arena, Goffredo Orazio Arena
The embryonic microenvironment is well known to be non-permissive for tumor development because early developmental signals naturally suppress the expression of proto-oncogenes. In an analogous manner, mimicking an early embryonic environment during embryonic stem cell culture has been shown to suppress oncogenic phenotypes of cancer cells. Exosomes derived from human embryonic stem cells harbor substances that mirror the content of the cells of origin and have been reported to reprogram hematopoietic stem/progenitor cells via horizontal transfer of mRNA and proteins...
2017: PloS One
https://www.readbyqxmd.com/read/28009971/dacomitinib-a-new-pan-egfr-inhibitor-is-effective-in-killing-ovarian-cancer-cells
#12
Lei Xu, Huini Wu, Chao Jiang, Hongcai Wang, Bei Gao, Shumei Yan, Yushu Qi, Shufeng Zhou
OBJECTIVE: Aberrant epidermal growth factor receptor (EGFR) is involved in a variety of cancers and its inhibitors have been studied for over a decade. We aim to investigate the effects of dacomitinib, a second generation pan-EGFR inhibitor, on ovarian cancer cells. METHODS: By immunohistochemistry, we studied the clinical significance of EGFR expression in epithelial ovarian cancer (EOC). The correlations between EGFR expression and the clinicopathological variables of patients with EOC were assessed using Pearson's X2 test...
November 2016: Discovery Medicine
https://www.readbyqxmd.com/read/27994173/transgenic-overexpression-of-baff-regulates-the-expression-of-immune-related-genes-in-zebrafish-danio-rerio
#13
Li Zhang, Chao Liu, Xin Zhou, Ying Xie, Libo Su, Qi Geng, Binghui Liu, Shufeng Liu
The B-cell activating factor (BAFF) is a member of tumour necrosis factor (TNF) superfamily that specifically regulates B lymphocyte proliferation and survival. Excess BAFF leads to overproduction of antibodies for secretion, anti-dsDNA antibodies and a lupus-like syndrome in mice. To investigate whether transgenic overexpression of the zebrafish BAFF leads to immunoglobulin changes and/or early maturing of the immune system, a Tol2-GFP-2A-BAFF/His recombinant plasmid was constructed by inserting a 2A peptide between the green fluorescent protein (GFP) and BAFF sequences...
December 2016: Journal of Genetics
https://www.readbyqxmd.com/read/27866969/overexpression-of-cd109-in-the-epidermis-differentially-regulates-alk1-versus-alk5-signaling-and-modulates-extracellular-matrix-synthesis-in-the-skin
#14
Joshua Vorstenbosch, Christopher M Nguyen, Shufeng Zhou, You Jung Seo, Aya Siblini, Kenneth W Finnson, Albane A Bizet, Simon D Tran, Anie Philip
Transforming growth factor-β (TGF-β) is a multifunctional growth factor involved in many physiological processes including wound healing and inflammation. Excessive TGF-β signaling in the skin has been implicated in fibrotic skin disorders such as keloids and scleroderma. We previously identified CD109 as a TGF-β co-receptor and inhibitor of TGF-β signaling and have shown that transgenic mice overexpressing CD109 in the epidermis display decreased scarring. In certain cell types, in addition to the canonical type I receptor, ALK5, which activates Smad2/3, TGF-β can signal through another type I receptor, ALK1, which activates Smad1/5...
March 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/26990640/comparative-rna-seq-analysis-reveals-that-regulatory-network-of-maize-root-development-controls-the-expression-of-genes-in-response-to-n-stress
#15
Xiujing He, Haixia Ma, Xiongwei Zhao, Shujun Nie, Yuhua Li, Zhiming Zhang, Yaou Shen, Qi Chen, Yanli Lu, Hai Lan, Shufeng Zhou, Shibin Gao, Guangtang Pan, Haijian Lin
Nitrogen (N) is an essential nutrient for plants, and it directly affects grain yield and protein content in cereal crops. Plant root systems are not only critical for anchorage in the soil, but also for N acquisition. Therefore, genes controlling root development might also affect N uptake by plants. In this study, the responses of nitrogen on root architecture of mutant rtcs and wild-type of maize were investigated by morphological and physiological analysis. Subsequently, we performed a comparative RNA-Seq analysis to compare gene expression profiles between mutant rtcs roots and wild-type roots under different N conditions...
2016: PloS One
https://www.readbyqxmd.com/read/26965367/loss-of-bmi1-causes-anomalies-in-retinal-development-and-degeneration-of-cone-photoreceptors
#16
Andrea Barabino, Vicky Plamondon, Mohamed Abdouh, Wassim Chatoo, Anthony Flamier, Roy Hanna, Shufeng Zhou, Noboru Motoyama, Marc Hébert, Joëlle Lavoie, Gilbert Bernier
Retinal development occurs through the sequential but overlapping generation of six types of neuronal cells and one glial cell type. Of these, rod and cone photoreceptors represent the functional unit of light detection and phototransduction and are frequently affected in retinal degenerative diseases. During mouse development, the Polycomb group protein Bmi1 is expressed in immature retinal progenitors and differentiated retinal neurons, including cones. We show here that Bmi1 is required to prevent post natal degeneration of cone photoreceptors and bipolar neurons and that inactivation of Chk2 or p53 could improve but not overcome cone degeneration in Bmi1(-/-) mice...
May 1, 2016: Development
https://www.readbyqxmd.com/read/26870784/a-novel-class-of-small-molecule-compounds-that-inhibit-hepatitis-c-virus-infection-by-targeting-the-prohibitin-craf-pathway
#17
Shufeng Liu, Wenyu Wang, Lauren E Brown, Chao Qiu, Neil Lajkiewicz, Ting Zhao, Jianhua Zhou, John A Porco, Tony T Wang
Identification of novel drug targets and affordable therapeutic agents remains a high priority in the fight against chronic hepatitis C virus (HCV) infection. Here, we report that the cellular proteins prohibitin 1 (PHB1) and 2 (PHB2) are pan-genotypic HCV entry factors functioning at a post-binding step. While predominantly found in mitochondria, PHBs localize to the plasma membrane of hepatocytes through their transmembrane domains and interact with both EGFR and CRaf. Targeting PHB by rocaglamide (Roc-A), a natural product that binds PHB1 and 2, reduced cell surface PHB1 and 2, disrupted PHB-CRaf interaction, and inhibited HCV entry at low nanomolar concentrations...
November 2015: EBioMedicine
https://www.readbyqxmd.com/read/26808496/comparative-proteomics-reveals-important-viral-host-interactions-in-hcv-infected-human-liver-cells
#18
COMPARATIVE STUDY
Shufeng Liu, Ting Zhao, BenBen Song, Jianhua Zhou, Tony T Wang
Hepatitis C virus (HCV) poses a global threat to public health. HCV envelop protein E2 is the major component on the virus envelope, which plays an important role in virus entry and morphogenesis. Here, for the first time, we affinity purified E2 complex formed in HCV-infected human hepatoma cells and conducted comparative mass spectrometric analyses. 85 cellular proteins and three viral proteins were successfully identified in three independent trials, among which alphafetoprotein (AFP), UDP-glucose: glycoprotein glucosyltransferase 1 (UGT1) and HCV NS4B were further validated as novel E2 binding partners...
2016: PloS One
https://www.readbyqxmd.com/read/26806283/electrochemical-hydrogen-sulfide-biosensors
#19
REVIEW
Tailin Xu, Nikki Scafa, Li-Ping Xu, Shufeng Zhou, Khalid Abdullah Al-Ghanem, Shahid Mahboob, Bunshi Fugetsu, Xueji Zhang
The measurement of sulfide, especially hydrogen sulfide, has held the attention of the analytical community due to its unique physiological and pathophysiological roles in biological systems. Electrochemical detection offers a rapid, highly sensitive, affordable, simple, and real-time technique to measure hydrogen sulfide concentration, which has been a well-documented and reliable method. This review details up-to-date research on the electrochemical detection of hydrogen sulfide (ion selective electrodes, polarographic hydrogen sulfide sensors, etc...
February 21, 2016: Analyst
https://www.readbyqxmd.com/read/26773801/multifaceted-ability-of-naturally-occurring-polyphenols-against-metastatic-cancer
#20
REVIEW
Qingyu Zhou, Lunawati L Bennett, Shufeng Zhou
Although cancer metastases are known to be the main cause of cancer-related deaths, truly effective antimetastatic therapeutics remain scarce in clinical practice. Naturally occurring polyphenols are the most abundant antioxidants in human diets. Many of them possess chemopreventive and chemotherapeutic properties against various types of cancer. Recent advances in understanding the molecular pathways that mediate cancer development and progression have led to an increase of interest in preclinical investigations on the mechanisms underlying anticancer activity of polyphenols...
April 2016: Clinical and Experimental Pharmacology & Physiology
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