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https://www.readbyqxmd.com/read/27866969/overexpression-of-cd109-in-the-epidermis-differentially-regulates-alk1-versus-alk5-signaling-and-modulates-extracellular-matrix-synthesis-in-the-skin
#1
Joshua Vorstenbosch, Christopher M Nguyen, Shufeng Zhou, You Jung Seo, Aya Siblini, Kenneth W Finnson, Albane A Bizet, Simon D Tran, Anie Philip
Transforming growth factor-beta (TGF-β) is a multifunctional growth factor involved in many physiological processes including wound healing and inflammation. Excessive TGF-β signaling in the skin has been implicated in fibrotic skin disorders such as keloids and scleroderma. We have previously identified CD109 as a TGF- β co-receptor and inhibitor of TGF-ß signaling, and have shown that transgenic mice overexpressing CD109 in the epidermis display decreased scarring. In certain cell types, in addition to the canonical type I receptor, ALK5 which activates Smad2/3, TGF-β can signal through another type I receptor ALK1 which activates Smad1/5...
November 17, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/26990640/comparative-rna-seq-analysis-reveals-that-regulatory-network-of-maize-root-development-controls-the-expression-of-genes-in-response-to-n-stress
#2
Xiujing He, Haixia Ma, Xiongwei Zhao, Shujun Nie, Yuhua Li, Zhiming Zhang, Yaou Shen, Qi Chen, Yanli Lu, Hai Lan, Shufeng Zhou, Shibin Gao, Guangtang Pan, Haijian Lin
Nitrogen (N) is an essential nutrient for plants, and it directly affects grain yield and protein content in cereal crops. Plant root systems are not only critical for anchorage in the soil, but also for N acquisition. Therefore, genes controlling root development might also affect N uptake by plants. In this study, the responses of nitrogen on root architecture of mutant rtcs and wild-type of maize were investigated by morphological and physiological analysis. Subsequently, we performed a comparative RNA-Seq analysis to compare gene expression profiles between mutant rtcs roots and wild-type roots under different N conditions...
2016: PloS One
https://www.readbyqxmd.com/read/26965367/loss-of-bmi1-causes-anomalies-in-retinal-development-and-degeneration-of-cone-photoreceptors
#3
Andrea Barabino, Vicky Plamondon, Mohamed Abdouh, Wassim Chatoo, Anthony Flamier, Roy Hanna, Shufeng Zhou, Noboru Motoyama, Marc Hébert, Joëlle Lavoie, Gilbert Bernier
Retinal development occurs through the sequential but overlapping generation of six types of neuronal cells and one glial cell type. Of these, rod and cone photoreceptors represent the functional unit of light detection and phototransduction and are frequently affected in retinal degenerative diseases. During mouse development, the Polycomb group protein Bmi1 is expressed in immature retinal progenitors and differentiated retinal neurons, including cones. We show here that Bmi1 is required to prevent post natal degeneration of cone photoreceptors and bipolar neurons and that inactivation of Chk2 or p53 could improve but not overcome cone degeneration in Bmi1(-/-) mice...
May 1, 2016: Development
https://www.readbyqxmd.com/read/26870784/a-novel-class-of-small-molecule-compounds-that-inhibit-hepatitis-c-virus-infection-by-targeting-the-prohibitin-craf-pathway
#4
Shufeng Liu, Wenyu Wang, Lauren E Brown, Chao Qiu, Neil Lajkiewicz, Ting Zhao, Jianhua Zhou, John A Porco, Tony T Wang
Identification of novel drug targets and affordable therapeutic agents remains a high priority in the fight against chronic hepatitis C virus (HCV) infection. Here, we report that the cellular proteins prohibitin 1 (PHB1) and 2 (PHB2) are pan-genotypic HCV entry factors functioning at a post-binding step. While predominantly found in mitochondria, PHBs localize to the plasma membrane of hepatocytes through their transmembrane domains and interact with both EGFR and CRaf. Targeting PHB by rocaglamide (Roc-A), a natural product that binds PHB1 and 2, reduced cell surface PHB1 and 2, disrupted PHB-CRaf interaction, and inhibited HCV entry at low nanomolar concentrations...
November 2015: EBioMedicine
https://www.readbyqxmd.com/read/26808496/comparative-proteomics-reveals-important-viral-host-interactions-in-hcv-infected-human-liver-cells
#5
COMPARATIVE STUDY
Shufeng Liu, Ting Zhao, BenBen Song, Jianhua Zhou, Tony T Wang
Hepatitis C virus (HCV) poses a global threat to public health. HCV envelop protein E2 is the major component on the virus envelope, which plays an important role in virus entry and morphogenesis. Here, for the first time, we affinity purified E2 complex formed in HCV-infected human hepatoma cells and conducted comparative mass spectrometric analyses. 85 cellular proteins and three viral proteins were successfully identified in three independent trials, among which alphafetoprotein (AFP), UDP-glucose: glycoprotein glucosyltransferase 1 (UGT1) and HCV NS4B were further validated as novel E2 binding partners...
2016: PloS One
https://www.readbyqxmd.com/read/26806283/electrochemical-hydrogen-sulfide-biosensors
#6
Tailin Xu, Nikki Scafa, Li-Ping Xu, Shufeng Zhou, Khalid Abdullah Al-Ghanem, Shahid Mahboob, Bunshi Fugetsu, Xueji Zhang
The measurement of sulfide, especially hydrogen sulfide, has held the attention of the analytical community due to its unique physiological and pathophysiological roles in biological systems. Electrochemical detection offers a rapid, highly sensitive, affordable, simple, and real-time technique to measure hydrogen sulfide concentration, which has been a well-documented and reliable method. This review details up-to-date research on the electrochemical detection of hydrogen sulfide (ion selective electrodes, polarographic hydrogen sulfide sensors, etc...
February 8, 2016: Analyst
https://www.readbyqxmd.com/read/26773801/multifaceted-ability-of-naturally-occurring-polyphenols-against-metastatic-cancer
#7
REVIEW
Qingyu Zhou, Lunawati L Bennett, Shufeng Zhou
Although cancer metastases are known to be the main cause of cancer-related deaths, truly effective antimetastatic therapeutics remain scarce in clinical practice. Naturally occurring polyphenols are the most abundant antioxidants in human diets. Many of them possess chemopreventive and chemotherapeutic properties against various types of cancer. Recent advances in understanding the molecular pathways that mediate cancer development and progression have led to an increase of interest in preclinical investigations on the mechanisms underlying anticancer activity of polyphenols...
April 2016: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/26621871/soluble-cd109-binds-tgf-%C3%AE-and-antagonizes-tgf-%C3%AE-signalling-and-responses
#8
Carter Li, Mark A Hancock, Priyanka Sehgal, Shufeng Zhou, Dieter P Reinhardt, Anie Philip
Transforming growth factor-β (TGF-β) is a multifunctional cytokine implicated in many diseases, including tissue fibrosis and cancer. TGF-β mediates diverse biological responses by signalling through type I and II TGF-β receptors (TβRI and TβRII). We have previously identified CD109, a glycosylphosphatidylinositol (GPI)-anchored protein, as a novel TGF-β co-receptor that negatively regulates TGF-β signalling and responses and demonstrated that membrane-anchored CD109 promotes TGF-β receptor degradation via a SMAD7/Smurf2-mediated mechanism...
March 1, 2016: Biochemical Journal
https://www.readbyqxmd.com/read/26582766/genetic-susceptibility-to-lipid-levels-and-lipid-change-over-time-and-risk-of-incident-hyperlipidemia-in-chinese-populations
#9
MULTICENTER STUDY
Xiangfeng Lu, Jianfeng Huang, Zengnan Mo, Jiang He, Laiyuan Wang, Xueli Yang, Aihua Tan, Shufeng Chen, Jing Chen, C Charles Gu, Jichun Chen, Ying Li, Liancheng Zhao, Hongfan Li, Yongchen Hao, Jianxin Li, James E Hixson, Yunzhi Li, Min Cheng, Xiaoli Liu, Jie Cao, Fangcao Liu, Chen Huang, Chong Shen, Jinjin Shen, Ling Yu, Lihua Xu, Jianjun Mu, Xianping Wu, Xu Ji, Dongshuang Guo, Zhengyuan Zhou, Zili Yang, Renping Wang, Jun Yang, Weili Yan, Xiaozhong Peng, Dongfeng Gu
BACKGROUND: Multiple genetic loci associated with lipid levels have been identified predominantly in Europeans, and the issue of to what extent these genetic loci can predict blood lipid levels increases over time and the incidence of future hyperlipidemia remains largely unknown. METHODS AND RESULTS: We conducted a meta-analysis of genome-wide association studies of lipid levels in 8344 subjects followed by replication studies including 14 739 additional individuals...
February 2016: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/26443633/differentiation-of-human-embryonic-stem-cells-into-cone-photoreceptors-through-simultaneous-inhibition-of-bmp-tgf%C3%AE-and-wnt-signaling
#10
Shufeng Zhou, Anthony Flamier, Mohamed Abdouh, Nicolas Tétreault, Andrea Barabino, Shashi Wadhwa, Gilbert Bernier
Cone photoreceptors are required for color discrimination and high-resolution central vision and are lost in macular degenerations, cone and cone/rod dystrophies. Cone transplantation could represent a therapeutic solution. However, an abundant source of human cones remains difficult to obtain. Work performed in model organisms suggests that anterior neural cell fate is induced 'by default' if BMP, TGFβ and Wnt activities are blocked, and that photoreceptor genesis operates through an S-cone default pathway...
October 1, 2015: Development
https://www.readbyqxmd.com/read/26283040/genetic-predisposition-to-higher-blood-pressure-increases-risk-of-incident-hypertension-and-cardiovascular-diseases-in-chinese
#11
MULTICENTER STUDY
Xiangfeng Lu, Jianfeng Huang, Laiyuan Wang, Shufeng Chen, Xueli Yang, Jianxin Li, Jie Cao, Jichun Chen, Ying Li, Liancheng Zhao, Hongfan Li, Fangcao Liu, Chen Huang, Chong Shen, Jinjin Shen, Ling Yu, Lihua Xu, Jianjun Mu, Xianping Wu, Xu Ji, Dongshuang Guo, Zhengyuan Zhou, Zili Yang, Renping Wang, Jun Yang, Weili Yan, Dongfeng Gu
Although multiple genetic markers associated with blood pressure have been identified by genome-wide association studies, their aggregate effect on risk of incident hypertension and cardiovascular disease is uncertain, particularly among East Asian who may have different genetic and environmental exposures from Europeans. We aimed to examine the association between genetic predisposition to higher blood pressure and risk of incident hypertension and cardiovascular disease in 26 262 individuals in 2 Chinese population-based prospective cohorts...
October 2015: Hypertension
https://www.readbyqxmd.com/read/25463102/elevated-fasting-glucose-as-a-potential-predictor-for-asymptomatic-cerebral-artery-stenosis-a-cross-sectional-study-in-chinese-adults
#12
Jing Wang, Jianwei Wu, Shufeng Zhang, Liqun Zhang, Chunxue Wang, Xiang Gao, Yong Zhou, Anxin Wang, Shouling Wu, Xingquan Zhao
BACKGROUND AND PURPOSE: Cerebral artery stenosis is known as an important cause of stroke, and elevated fasting glucose level is also considered as a risk factor for stroke. Our aim was to exam whether elevated fasting glucose is associated with cerebral artery stenosis, especially asymptomatic cerebral artery stenosis. METHODS: The current study included 5309 participants who were age of 40 years or older, and free of stroke, transient ischemic attack, and coronary artery disease...
December 2014: Atherosclerosis
https://www.readbyqxmd.com/read/25266310/transfer-of-malignant-trait-to-immortalized-human-cells-following-exposure-to-human-cancer-serum
#13
Mohamed Abdouh, Shufeng Zhou, Vincenzo Arena, Manuel Arena, Anthoula Lazaris, Ronald Onerheim, Peter Metrakos, Goffredo Orazio Arena
BACKGROUND: Human cancer cells can transfer signaling molecules to neighboring and distant cells predisposing them to malignant transformation. This process might contribute to tumor progression and invasion through delivery of oncogenes or inhibitors of tumor suppressor genes, derived from the primary tumor cells, to susceptible target cells. The oncogenic potential of human cancer serum has been described in immortalized mouse fibroblasts but has not been shown yet in human cells. The objective of this study was to determine whether metastatic cancer patient sera have the ability to induce neoplastic transformation in immortalized human embryonic kidney (HEK293) cells, human embryonic stem cells (hESCs), human mesenchymal stem cells (hMSCs) and human adult liver fibroblasts (hALFs)...
2014: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/25249183/genome-wide-association-study-in-chinese-identifies-novel-loci-for-blood-pressure-and-hypertension
#14
Xiangfeng Lu, Laiyuan Wang, Xu Lin, Jianfeng Huang, C Charles Gu, Meian He, Hongbing Shen, Jiang He, Jingwen Zhu, Huaixing Li, James E Hixson, Tangchun Wu, Juncheng Dai, Ling Lu, Chong Shen, Shufeng Chen, Lin He, Zengnan Mo, Yongchen Hao, Xingbo Mo, Xueli Yang, Jianxin Li, Jie Cao, Jichun Chen, Zhongjie Fan, Ying Li, Liancheng Zhao, Hongfan Li, Fanghong Lu, Cailiang Yao, Lin Yu, Lihua Xu, Jianjun Mu, Xianping Wu, Ying Deng, Dongsheng Hu, Weidong Zhang, Xu Ji, Dongshuang Guo, Zhirong Guo, Zhengyuan Zhou, Zili Yang, Renping Wang, Jun Yang, Xiaoyang Zhou, Weili Yan, Ningling Sun, Pingjin Gao, Dongfeng Gu
Hypertension is a common disorder and the leading risk factor for cardiovascular disease and premature deaths worldwide. Genome-wide association studies (GWASs) in the European population have identified multiple chromosomal regions associated with blood pressure, and the identified loci altogether explain only a small fraction of the variance for blood pressure. The differences in environmental exposures and genetic background between Chinese and European populations might suggest potential different pathways of blood pressure regulation...
February 1, 2015: Human Molecular Genetics
https://www.readbyqxmd.com/read/25206611/mechanism-of-kinect-based-virtual-reality-training-for-motor-functional-recovery-of-upper-limbs-after-subacute-stroke
#15
Xiao Bao, Yurong Mao, Qiang Lin, Yunhai Qiu, Shaozhen Chen, Le Li, Ryan S Cates, Shufeng Zhou, Dongfeng Huang
The Kinect-based virtual reality system for the Xbox 360 enables users to control and interact with the game console without the need to touch a game controller, and provides rehabilitation training for stroke patients with lower limb dysfunctions. However, the underlying mechanism remains unclear. In this study, 18 healthy subjects and five patients after subacute stroke were included. The five patients were scanned using functional MRI prior to training, 3 weeks after training and at a 12-week follow-up, and then compared with healthy subjects...
November 5, 2013: Neural Regeneration Research
https://www.readbyqxmd.com/read/25200254/risk-factors-for-preterm-premature-rupture-of-membranes-in-chinese-women-from-urban-cities
#16
Qiongjie Zhou, Weiyuan Zhang, Huan Xu, Huan Liang, Yan Ruan, Shufeng Zhou, Xiaotian Li
OBJECTIVE: To investigate the prevalence of preterm premature rupture of membranes (PPROM) in urban areas in China and examine the associated risk factors. METHODS: A population-based, prospective study was undertaken in 14 cities in China between January 1, 2011, and January 31, 2012. Women were recruited at their first prenatal-care visit, when maternal characteristics were recorded. Risk factors were analyzed by one-way analysis of variance. RESULTS: Of 112 439 women included in analyses, 3077 (2...
December 2014: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/25185979/editorial-current-topics-in-pharmacogenomics
#17
EDITORIAL
Siva Kumar Panguluri, Kevin B Sneed, Yashwant Pathak, Shufeng Zhou
No abstract text is available yet for this article.
2014: Recent Patents on Biotechnology
https://www.readbyqxmd.com/read/24929517/-cloning-and-functional-validation-of-promoter-of-mo-molybdopterin-cofactor-sulfurase-gene-in-maize
#18
Xuehuan Gao, Fengling Fu, Wei Mu, Shufeng Zhou, Suzhi Zhang, Wanchen Li
To overcome the problems caused by the over-expression of exogenous genes under the control of constitutive promoters, the promoter (ABA3s) sequence of maize (Zea mays) mo-molybdopterin cofactor sulfurase gene (ABA3) was cloned homologously, analyzed for its abiotic stress-responsive elements by the PlantCARE software, and detected for differential expression of the ABA3 gene under the abiotic stresses by real-time quantitative PCR. Then, this promoter was used to construct expression vector to start GUS (β-glucuronidase) gene, and transform maize calli by biolistics...
June 2014: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/24812088/syncytin-proteins-incorporated-in-placenta-exosomes-are-important-for-cell-uptake-and-show-variation-in-abundance-in-serum-exosomes-from-patients-with-preeclampsia
#19
Amandine Vargas, Shufeng Zhou, Maude Éthier-Chiasson, Denis Flipo, Julie Lafond, Caroline Gilbert, Benoit Barbeau
Exosomes are extracellular vesicles that mediate intercellular communication and are involved in several biological processes. The objective of our study was to determine whether endogenous retrovirus group WE, member l (ERVWE1)/syncytin-1 and endogenous retrovirus group FRD, member 1 (ERVFRDE1)/syncytin-2, encoded by human endogenous retrovirus (HERV) envelope (env) genes, are present at the surface of exosomes produced by placenta-derived villous cytotrophoblasts and whether they play a role in cellular uptake of exosomes...
August 2014: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/24687999/common-variants-in-tgfbr2-and-mir-518-genes-are-associated-with-hypertension-in-the-chinese-population
#20
Jinfeng Chen, Xianghai Zhao, Hairu Wang, Yanchun Chen, Wen Wang, Wei Zhou, Xuecai Wang, Junming Tang, Yanping Zhao, Xiangfeng Lu, Shufeng Chen, Laiyuan Wang, Chong Shen, Song Yang
BACKGROUND: An animal study reported that TGF-β1 maturation was linked to the homeostasis of blood pressure and elastogenesis of essential hypertension (EH). Recent advances require further research of TGF-β1 receptor in EH. METHODS: A case-control study comprised of 2,012 adult hypertension case patients and 2,210 adult control subjects was conducted, and the association with blood pressure was further tested in children. Logistic regression and calculated genetic risk score were used to evaluate the effects of one single nucleotide polymorphism (SNP) and multiple SNPs on EH, respectively...
October 2014: American Journal of Hypertension
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