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https://www.readbyqxmd.com/read/28208799/microbial-detoxification-of-deoxynivalenol-don-assessed-via-a-lemna-minor-l-bioassay-through-biotransformation-to-3-epi-don-and-3-epi-dom-1
#1
Ilse Vanhoutte, Laura De Mets, Marthe De Boevre, Valdet Uka, José Diana Di Mavungu, Sarah De Saeger, Leen De Gelder, Kris Audenaert
Mycotoxins are toxic metabolites produced by fungi. To mitigate mycotoxins in food or feed, biotransformation is an emerging technology in which microorganisms degrade toxins into non-toxic metabolites. To monitor deoxynivalenol (DON) biotransformation, analytical tools such as ELISA and liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) are typically used. However, these techniques do not give a decisive answer about the remaining toxicity of possible biotransformation products. Hence, a bioassay using Lemna minor L...
February 13, 2017: Toxins
https://www.readbyqxmd.com/read/28185777/survivorship-and-patient-satisfaction-of-robotic-assisted-medial-unicompartmental-knee-arthroplasty-at-a-minimum-two-year-follow-up
#2
Andrew D Pearle, Jelle P van der List, Lily Lee, Thomas M Coon, Todd A Borus, Martin W Roche
BACKGROUND: Successful clinical outcomes following unicompartmental knee arthroplasty (UKA) depend on lower limb alignment, soft tissue balance and component positioning, which can be difficult to control using manual instrumentation. Although robotic-assisted surgery more reliably controls these surgical factors, studies assessing outcomes of robotic-assisted UKA are lacking. Therefore, a prospective multicenter study was performed to assess outcomes of robotic-assisted UKA. METHODS: A total of 1007 consecutive patients (1135 knees) underwent robotic-assisted medial UKA surgery from six surgeons at separate institutions between March 2009 and December 2011...
February 6, 2017: Knee
https://www.readbyqxmd.com/read/28176602/comparison-of-hto-with-articular-cartilage-surgery-and-uka-in-unicompartmental-oa
#3
Yoon Sang Jeon, Chi Hoon Ahn, Myung-Ku Kim
PURPOSE: The purpose of this article was to assess the clinical outcome of high tibial osteotomy (HTO) with articular cartilage surgery compared with unicompartmental knee arthroplasty (UKA) in unicompartmental osteoarthritis (OA). METHODS: We designed retrospective study and evaluated 47 patients with unicompartmental OA (Kellgren-Laurence [K-L] grade ≥III OA). Two groups of patients underwent either HTO with articular cartilage surgery or UKA by the senior author between January 2010 and April 2013...
January 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28149893/is-the-revision-of-a-primary-tka-really-as-easy-and-safe-as-the-revision-of-a-primary-uka
#4
COMMENT
Kevin Staats, Christian Merle, Tom Schmidt-Braekling, Friedrich Boettner, Reinhard Windhager, Wenzel Waldstein
No abstract text is available yet for this article.
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28110847/improved-survival-of-computer-assisted-unicompartmental-knee-arthroplasty-252-cases-with-a-minimum-follow-up-of-5-years
#5
Majid Chowdhry, Raghbir S Khakha, Mark Norris, Amin Kheiran, Sandeep K Chauhan
BACKGROUND: Unicompartmental knee arthroplasty (UKA) is an underutilized implant for medial tibiofemoral arthritis despite proven benefits in performance and reduced complications. This is likely related to registry recorded higher revision rates compared with total knee arthroplasty. It is our feeling that better component alignment resulting from the usage of computer-assisted surgery should improve longer-term functional results and survival of UKAs. METHODS: Between August 2003 and June 2007, 265 medial UKAs were performed in 264 consecutive patients using navigation...
November 23, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28099301/unicompartmental-knee-arthroplasty-provides-higher-activity-and-durability-than-valgus-producing-proximal-tibial-osteotomy-at-5-to-7-years
#6
Aaron J Krych, Patrick Reardon, Paul Sousa, Ayoosh Pareek, Michael Stuart, Mark Pagnano
BACKGROUND: The cases of patients with medial compartment osteoarthritis who were ≤55 years old and had a proximal tibial osteotomy (PTO) or medial unicompartmental knee arthroplasty (UKA) were compared. Outcomes included postoperative activity level, function, and survivorship free of revision to total knee arthroplasty. METHODS: Between 1998 and 2013, data were available for 240 patients between 18 and 55 years old with medial compartment arthritis and varus malalignment who were treated either with PTO (57 patients) or with UKA (183 patients)...
January 18, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28098779/unravelling-the-diversity-of-the-cyclopiazonic-acid-family-of-mycotoxins-in-aspergillus-flavus-by-uhplc-triple-tof-hrms
#7
Valdet Uka, Geromy G Moore, Natalia Arroyo-Manzanares, Dashnor Nebija, Sarah De Saeger, José Diana Di Mavungu
Cyclopiazonic acid (α-cyclopiazonic acid, α-CPA) is an indole-hydrindane-tetramic acid neurotoxin produced by various fungal species, including the notorious food and feed contaminant Aspergillus flavus. Despite its discovery in A. flavus cultures approximately 40 years ago, its contribution to the A. flavus mycotoxin burden is consistently minimized by our focus on the more potent carcinogenic aflatoxins also produced by this fungus. Here, we report the screening and identification of several CPA-type alkaloids not previously found in A...
January 13, 2017: Toxins
https://www.readbyqxmd.com/read/28077394/metal-backed-versus-all-polyethylene-unicompartmental-knee-arthroplasty-proximal-tibial-strain-in-an-experimentally-validated-finite-element-model
#8
C E H Scott, M J Eaton, R W Nutton, F A Wade, S L Evans, P Pankaj
OBJECTIVES: Up to 40% of unicompartmental knee arthroplasty (UKA) revisions are performed for unexplained pain which may be caused by elevated proximal tibial bone strain. This study investigates the effect of tibial component metal backing and polyethylene thickness on bone strain in a cemented fixed-bearing medial UKA using a finite element model (FEM) validated experimentally by digital image correlation (DIC) and acoustic emission (AE). MATERIALS AND METHODS: A total of ten composite tibias implanted with all-polyethylene (AP) and metal-backed (MB) tibial components were loaded to 2500 N...
January 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28067099/dynamic-rsa-for-the-evaluation-of-inducible-micromotion-of-oxford-uka-during-step-up-and-step-down-motion
#9
Kristian Horsager, Bart L Kaptein, Lone RøMer, Peter B Jørgensen, Maiken Stilling
Background and purpose - Implant inducible micromotions have been suggested to reflect the quality of the fixation interface. We investigated the usability of dynamic RSA for evaluation of inducible micromotions of the Oxford Unicompartmental Knee Arthroplasty (UKA) tibial component, and evaluated factors that have been suggested to compromise the fixation, such as fixation method, component alignment, and radiolucent lines (RLLs). Patients and methods - 15 patients (12 men) with a mean age of 69 (55-86) years, with an Oxford UKA (7 cemented), were studied after a mean time in situ of 4...
January 9, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28065624/outcome-of-unicondylar-knee-arthroplasty-vs-total-knee-arthroplasty-for-early-medial-compartment-arthritis-a-randomized-study
#10
Vikas Kulshrestha, Barun Datta, Santhosh Kumar, Gaurav Mittal
BACKGROUND: With increasing number of patients with early osteoarthritis of knee opting for total knee arthroplasty (TKA), there has been increase in patients dissatisfied with surgical outcomes. It is being presumed that offering unicondylar knee arthroplasty (UKA) to them would improve outcomes. METHODS: Primary objective of our study was to look for any difference in patient-reported outcome and function at 2-year follow-up in patients undergoing UKA as compared to TKA...
December 23, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28060788/outpatient-total-hip-arthroplasty-total-knee-arthroplasty-and-unicompartmental-knee-arthroplasty-a-systematic-review-of-the-literature
#11
Michael Pollock, Lyndsay Somerville, Andrew Firth, Brent Lanting
BACKGROUND: The demand for total hip arthroplasty (THA), total knee arthroplasty (TKA), and unicompartmental knee arthroplasty (UKA) is growing rapidly because of the proven success of these procedures and an increase in the aging population. However, resources are limited and health-care budgets are finite. Recently, a number of care providers have started performing these procedures on an outpatient basis, with the patients being discharged from the hospital on the day of surgery. The primary objective of this systematic review was to examine the evidence regarding the safety and feasibility of performing THA, TKA, or UKA on an outpatient basis...
December 27, 2016: JBJS Reviews
https://www.readbyqxmd.com/read/28056570/different-incidences-of-knee-arthroplasty-in-the-nordic-countries
#12
Mika J NiemeläInen, Keijo T MäKelä, Otto Robertsson, Annette W-Dahl, Ove Furnes, Anne M Fenstad, Alma B Pedersen, Henrik M Schrøder, Heini Huhtala, Antti Eskelinen
Background and purpose - The annual number of total knee arthroplasties (TKAs) has increased worldwide in recent years. To make projections regarding future needs for primaries and revisions, additional knowledge is important. We analyzed and compared the incidences among 4 Nordic countries Patients and methods - Using Nordic Arthroplasty Register Association (NARA) data from 4 countries, we analyzed differences between age and sex groups. We included patients over 30 years of age who were operated with TKA or unicompartmental knee arthroplasty (UKA) during the period 1997-2012...
January 6, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28053251/bias-and-unicompartmental-knee-arthroplasty
#13
REVIEW
D W Murray, A D Liddle, A Judge, H Pandit
We recently published a paper comparing the incidence of adverse outcomes after unicompartmental and total knee arthroplasty (UKA and TKA). The conclusion of this study, which was in favour of UKA, was dismissed as "biased" in a review in Bone & Joint 360 Although this study is one of the least biased comparisons of UKA and TKA, this episode highlights the biases that exist both for and against UKA. In this review, we explore the different types of bias, particularly selection, reporting and measurement. We conclude that comparisons between UKA and TKA are open to bias...
January 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28045236/usefulness-of-a-ct-guided-hookwire-marking-in-laparoscopic-partial-hepatectomy-for-hepatocellular-carcinoma-invisible-on-ultrasonography
#14
Kazuteru Monden, Hiroshi Sadamori, Masayoshi Hioki, Kanyu Nakano, Shinya Asami, Satoshi Ohno, Kyo Sasaki, Toru Ueki, Kazuhisa Yabushita, Mayu Uka, Tsuyoshi Hyodo, Kousaku Sakaguchi, Norihisa Takakura
INTRODUCTION: The intra-operative detection of hepatocellular carcinoma (HCC) by ultrasonography is indispensable for laparoscopic partial hepatectomy. However, it is occasionally difficult to localize an HCC on an ultrasound in chronic liver disease. Two cases of partial hepatectomy using hookwire marking under CT guidance are presented. MATERIALS AND SURGICAL TECHNIQUE: The location of the HCC was identified by CT scan, and the puncture site was determined. A hookwire system, made of a stainless steel hook, was used to localize the HCC...
February 2017: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/28042121/conversion-of-a-unicompartmental-knee-arthroplasty-to-a-total-knee-arthroplasty-can-we-achieve-a-primary-result
#15
REVIEW
E Thienpont
OBJECTIVES: Unicompartmental knee arthroplasty (UKA) is a potential treatment for isolated bone on bone osteoarthritis when limited to a single compartment. The risk for revision of UKA is three times higher than for total knee arthroplasty (TKA). The aim of this review was to discuss the different revision options after UKA failure. MATERIALS AND METHODS: A search was performed for English language articles published between 2006 and 2016. After reviewing titles and abstracts, 105 papers were selected for further analysis...
January 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28039023/determination-of-the-accuracy-of-navigated-kinematic-unicompartmental-knee-arthroplasty-a-2-year-follow-up
#16
Andrea L Grant, Kenji D Doma, Kaushik Hazratwala
BACKGROUND: Unicompartmental knee arthroplasty (UKA) lacks history of patient satisfaction and research addressing technique validity. The aim of this study was to determine minimally invasive navigated kinematic UKA accuracy by comparing postoperative limb alignment with preoperative stress values. METHODS: A single-center retrospective study was conducted on 53 consecutive patients (postoperative alignment: varus n = 51, valgus n = 2) who underwent computer navigation assisted UKA...
November 29, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28032123/ten-year-patient-reported-outcomes-following-total-and-minimally-invasive-unicompartmental-knee-arthroplasty-a-propensity-score-matched-cohort-analysis
#17
Edward Burn, Maria T Sanchez-Santos, Hemant G Pandit, Thomas W Hamilton, Alexander D Liddle, David W Murray, Rafael Pinedo-Villanueva
PURPOSE: For patients with medial compartment arthritis who have failed non-operative treatment, either a total knee arthroplasty (TKA) or a unicompartmental knee arthroplasty (UKA) can be undertaken. This analysis considers how the choice between UKA and TKA affects long-term patient-reported outcome measures (PROMs). METHODS: The Knee Arthroplasty Trial (KAT) and a cohort of patients who received a minimally invasive UKA provided data. Propensity score matching was used to identify comparable patients...
December 29, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28005115/robotic-technology-produces-more-conservative-tibial-resection-than-conventional-techniques-in-uka
#18
Danielle Y Ponzio, Jess H Lonner
Conversion of unicompartmental knee arthroplasty (UKA) to total knee arthroplasty (TKA) may be relatively simple when tibial resection is conservative during the index UKA. However, with greater tibial resection, conversion to TKA may be complicated by osseous insufficiency, requiring stems and augments, and potentially compromising patient outcomes and TKA durability. Robotic assistance in UKA is shown to enhance the bone preparation accuracy. In our retrospective comparison of polyethylene insert sizes, 8-mm or 9-mm polyethylene inserts were used in 93...
November 2016: American Journal of Orthopedics
https://www.readbyqxmd.com/read/28005097/why-do-lateral-unicompartmental-knee-arthroplasties-fail-today
#19
REVIEW
Jelle P van der List, Hendrik A Zuiderbaan, Andrew D Pearle
In large studies, the failure modes of lateral unicompartmental knee arthroplasty (UKA) are usually presented in combination with medial UKA, which is mainly due to low surgical frequency of lateral UKA. Because lateral UKA differs from medial UKA in anatomic and kinematic characteristics, failure modes of lateral UKA should not be presented in combination with medial UKA. Therefore, we performed a systematic review to assess failure modes in lateral UKA and compared failure modes in cohort studies with those found in registry-based studies...
November 2016: American Journal of Orthopedics
https://www.readbyqxmd.com/read/28002437/non-sagittal-knee-joint-kinematics-and-kinetics-during-gait-on-level-and-sloped-grounds-with-unicompartmental-and-total-knee-arthroplasty-patients
#20
Igor Komnik, Markus Peters, Johannes Funken, Sina David, Stefan Weiss, Wolfgang Potthast
After knee arthroplasty (KA) surgery, patients experience abnormal kinematics and kinetics during numerous activities of daily living. Biomechanical investigations have focused primarily on level walking, whereas walking on sloped surfaces, which is stated to affect knee kinematics and kinetics considerably, has been neglected to this day. This study aimed to analyze over-ground walking on level and sloped surfaces with a special focus on transverse and frontal plane knee kinematics and kinetics in patients with KA...
2016: PloS One
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